TDMS Study 88004-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DIVINYLBENZENE DATE: 12/17/03
EXPERIMENT: 88004 TEST: 05 TIME: 11:48:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 88004B
PATHOLOGIST: RENNE, ROGER CAS: 1321-74-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DIVINYLBENZENE DATE: 12/17/03
EXPERIMENT: 88004 TEST: 05 TIME: 11:48:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 88004B
PATHOLOGIST: RENNE, ROGER CAS: 1321-74-0
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 355 506 536 543 561 589 589 612 612 623 |
| 638 666 670 675 682 701 704 722 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 106 393 569 582 605 654 654 659 682 704 |
| 708 710 717 722 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 114 460 544 568 578 586 617 619 653 661 |
| 676 687 694 694 717 722 722 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 513 562 567 569 589 614 633 638 674 680 |
| 680 682 687 694 708 710 723 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 98.0 92.0 86.0 78.0 62.0 |
| | |
| | |
|100 PPM | 100.0 98.0 98.0 98.0 96.0 96.0 96.0 90.0 84.0 70.0 |
| | |
| | |
|200 PPM | 100.0 98.0 98.0 98.0 98.0 96.0 94.0 88.0 80.0 64.0 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 84.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 100 PPM 200 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 70.0% 64.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.435N P=0.907N P=0.853N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 616.3 612.9 613.1 647.1 |
|NATURAL DEATHS (C) | (20.8) (42.6) (34.0) (15.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 686.2 694.2 687.3 699.5 |
|(STANDARD ERROR) | (11.0) (14.6) (14.4) ( 7.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 436 437 437 455 477 501 515 533 549 625 |
| 631 687 694 703 710 716 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 1 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 374 487 542 543 561 617 638 642 666 670 |
| 670 688 696 703 703 708 711 715 729 |
| CENSORED DEATHS |
| 506 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 374 481 493 497 500 582 586 614 654 666 |
| 673 704 711 712 715 722 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 151 516 523 525 529 535 535 540 551 563 |
| 586 586 589 600 600 613 617 626 626 631 |
| 653 653 656 656 684 708 708 712 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 90.0 84.0 82.0 78.0 66.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 98.0 98.0 91.9 89.9 83.7 61.3 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 90.0 86.0 82.0 66.0 |
| | |
| | |
|400 PPM | 100.0 98.0 98.0 98.0 98.0 98.0 84.0 70.0 52.0 44.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 100 PPM 200 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 61.3% 66.0% 44.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.019 P=0.901 P=1.000N P=0.049 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 578.1 634.9 612.4 588.3 |
|NATURAL DEATHS (C) | (27.2) (21.5) (26.3) (19.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 679.0 690.0 690.7 651.1 |
|(STANDARD ERROR) | (13.8) (11.1) (11.9) (14.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIVINYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
100 PPM = 2
200 PPM = 3
400 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 23 1 4
|
| 23 1 2 3 14 4
|
96 + 2 3 1 13 2
|
| 11 42 2
|
92 + 1 1332 4 2
|
| 1 33 1 24 2
|
P 88 + 3 43 4
E |
R | 1 1 44 2 2
C |
E 84 + 3 4 3 2 42
N |
T | 11 3 3 42 2
|
S 80 + 1 1 3 3 22
U |
R | 1 13 3
V |
I 76 + 433 22
V |
A | 11 44 22
L |
72 + 11 3 43
|
| 1 1 32 2
|
68 + 4 4
|
| 1 1
|
64 + 3 3
|
| 1 1
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
DIVINYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
100 PPM = 2
200 PPM = 3
400 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1
| 4 2 32 4
| 1 1 323 4 4 2
| 1 1 33 44 2 2
P 90 + 1 1 44 2 3 2
E | 1 1 2 2
R | 1 141 3 3 3
C | 1 4 1 2 3 2
E 80 + 4 4 11 33
N | 1 23 1 3
T | 4 44 1113
| 2113
S 70 + 4 4 2113
U | 44 11
R | 44 221 1
V | 44 2 2
I 60 + 4 4
V |
A |
L | 4 4
50 + 4 4
|
| 4 4
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 26 obs hidden.