TDMS Study 97013-07 Pathology Tables
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:42:48
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:42:48
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Dosing Accident 1
Survivors
Terminal Sacrifice 15 14 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Hyperkeratosis 1 (100%)
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%)
Infiltration Cellular, Lymphocyte 5 (33%) 4 (27%) 3 (20%)
Inflammation 14 (93%) 15 (100%) 14 (93%) 14 (93%)
Hepatocyte, Fatty Change 2 (13%) 2 (13%) 3 (20%) 11 (73%)
Hepatocyte, Vacuolization Cytoplasmic 10 (67%) 9 (60%) 10 (67%) 13 (87%)
Stomach, Forestomach (15) (15) (15) (15)
Inflammation 1 (7%) 1 (7%)
Epithelium, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Subcapsular, Hyperplasia 14 (93%) 15 (100%) 12 (80%) 14 (93%)
Parathyroid Gland (2)
Cyst 2 (100%)
Pituitary Gland (15) (15) (15) (15)
Cyst 1 (7%)
Hyperplasia 1 (7%)
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 (7%) 1 (7%)
Inflammation 3 (20%) 1 (7%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:42:48
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 2 (13%) 1 (7%) 2 (13%) 2 (13%)
Uterus (15) (15) (15) (15)
Inflammation 2 (13%) 2 (13%)
Necrosis 1 (7%)
Thrombosis 1 (7%)
Endometrium, Hyperplasia, Cystic 9 (60%) 9 (60%) 12 (80%) 10 (67%)
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HEMATOPOIETIC SYSTEM
Lymph Node (2)
Mediastinal, Atrophy 1 (50%)
Lymph Node, Mandibular (15) (15) (15) (15)
Atrophy 1 (7%)
Lymph Node, Mesenteric (15) (15) (15) (14)
Atrophy 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 (13%) 2 (13%)
Thymus (15) (15) (15) (15)
Atrophy 2 (13%)
Cyst 6 (40%) 5 (33%) 9 (60%) 7 (47%)
Hyperplasia, Atypical 1 (7%)
Necrosis 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (2)
Subcutaneous Tissue, Edema 1 (50%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:42:48
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (1)
Hydrocephalus 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 3 (20%) 2 (13%) 1 (7%)
Infiltration Cellular, Histiocyte 1 (7%) 1 (7%)
Inflammation 1 (7%)
Pleura (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 12 (80%) 11 (73%) 7 (47%) 7 (47%)
Hydronephrosis 1 (7%)
Inflammation 1 (7%)
Nephropathy 1 (7%) 3 (20%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:42:48
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Survivors
Terminal Sacrifice 15 15 15 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 2 (13%)
Inflammation 13 (87%) 14 (93%) 13 (87%) 15 (100%)
Necrosis 1 (7%)
Hepatocyte, Fatty Change 10 (67%) 9 (60%) 4 (27%) 11 (73%)
Hepatocyte, Vacuolization Cytoplasmic 15 (100%) 15 (100%) 13 (87%) 15 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 (7%)
Inflammation 1 (7%) 1 (7%) 1 (7%)
Epithelium, Hyperplasia 2 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 6 (40%) 2 (13%)
Subcapsular, Hyperplasia 2 (13%) 6 (40%) 6 (40%) 3 (20%)
Pituitary Gland (14) (15) (15) (15)
Cyst 1 (7%) 4 (27%) 2 (13%)
Thyroid Gland (15) (15) (15) (15)
Inflammation 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:42:48
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Granuloma Sperm 2 (13%)
Inflammation 1 (7%) 1 (7%)
Testes (15) (15) (15) (15)
Inflammation, Granulomatous 1 (7%)
Mineralization 1 (7%)
Germinal Epithelium, Degeneration 3 (20%) 2 (13%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15)
Lymphoid Follicle, Hyperplasia 1 (7%)
Thymus (15) (15) (15) (15)
Cyst 11 (73%) 9 (60%) 9 (60%) 11 (73%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (1)
Hydrocephalus 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 06/11/04
Route: GAVAGE Time: 08:42:48
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 2 (13%) 5 (33%) 2 (13%)
Hydronephrosis 1 (7%)
Nephropathy 8 (53%) 9 (60%) 8 (53%) 8 (53%)
Renal Tubule, Degeneration 4 (27%)
Renal Tubule, Vacuolization Cytoplasmic 12 (80%) 5 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
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