TDMS Study 97013-07 Pathology Tables
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:45:25
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:45:25
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Dosing Accident 1
Survivors
Terminal Sacrifice 15 14 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Hyperkeratosis 1 [1.0]
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 [1.0]
Infiltration Cellular, Lymphocyte 5 [1.2] 4 [1.0] 3 [1.0]
Inflammation 14 [1.0] 15 [1.0] 14 [1.0] 14 [1.1]
Hepatocyte, Fatty Change 2 [1.0] 2 [1.0] 3 [1.0] 11 [1.3]
Hepatocyte, Vacuolization Cytoplasmic 10 [1.0] 9 [1.0] 10 [1.0] 13 [1.5]
Stomach, Forestomach (15) (15) (15) (15)
Inflammation 1 [1.0] 1 [1.0]
Epithelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Subcapsular, Hyperplasia 14 [1.0] 15 [1.0] 12 [1.0] 14 [1.0]
Parathyroid Gland (2)
Cyst 2 [2.0]
Pituitary Gland (15) (15) (15) (15)
Cyst 1 [1.0]
Hyperplasia 1 [2.0]
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 [1.0] 1 [1.0]
Inflammation 3 [1.3] 1 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:45:25
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation 1 [2.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 2 [1.0] 1 [2.0] 2 [1.0] 2 [1.0]
Uterus (15) (15) (15) (15)
Inflammation 2 [1.0] 2 [1.0]
Necrosis 1 [3.0]
Thrombosis 1 [2.0]
Endometrium, Hyperplasia, Cystic 9 [1.3] 9 [1.3] 12 [1.2] 10 [1.5]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2)
Mediastinal, Atrophy 1 [3.0]
Lymph Node, Mandibular (15) (15) (15) (15)
Atrophy 1 [3.0]
Lymph Node, Mesenteric (15) (15) (15) (14)
Atrophy 1 [2.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 [1.0] 2 [1.5]
Thymus (15) (15) (15) (15)
Atrophy 2 [2.5]
Cyst 6 [1.0] 5 [1.0] 9 [1.0] 7 [1.0]
Hyperplasia, Atypical 1 [2.0]
Necrosis 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (2)
Subcutaneous Tissue, Edema 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:45:25
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (1)
Hydrocephalus 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 3 [1.0] 2 [1.0] 1 [1.0]
Infiltration Cellular, Histiocyte 1 [1.0] 1 [1.0]
Inflammation 1 [1.0]
Pleura (1)
Inflammation, Suppurative 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 12 [1.0] 11 [1.0] 7 [1.0] 7 [1.0]
Hydronephrosis 1 [3.0]
Inflammation 1 [1.0]
Nephropathy 1 [1.0] 3 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:45:25
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Survivors
Terminal Sacrifice 15 15 15 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 2 [1.0]
Inflammation 13 [1.0] 14 [1.0] 13 [1.0] 15 [1.0]
Necrosis 1 [1.0]
Hepatocyte, Fatty Change 10 [1.0] 9 [1.1] 4 [1.0] 11 [1.3]
Hepatocyte, Vacuolization Cytoplasmic 15 [1.9] 15 [1.9] 13 [1.2] 15 [1.5]
Stomach, Forestomach (15) (15) (15) (15)
Hyperkeratosis 1 [1.0]
Inflammation 1 [1.0] 1 [1.0] 1 [1.0]
Epithelium, Hyperplasia 2 [1.5]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 6 [1.0] 2 [1.0]
Subcapsular, Hyperplasia 2 [1.0] 6 [1.0] 6 [1.0] 3 [1.0]
Pituitary Gland (14) (15) (15) (15)
Cyst 1 [1.0] 4 [1.0] 2 [1.0]
Thyroid Gland (15) (15) (15) (15)
Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:45:25
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Granuloma Sperm 2 [2.0]
Inflammation 1 [1.0] 1 [1.0]
Testes (15) (15) (15) (15)
Inflammation, Granulomatous 1 [2.0]
Mineralization 1 [1.0]
Germinal Epithelium, Degeneration 3 [1.3] 2 [1.5] 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15)
Lymphoid Follicle, Hyperplasia 1 [2.0]
Thymus (15) (15) (15) (15)
Cyst 11 [1.1] 9 [1.2] 9 [1.2] 11 [1.1]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (1)
Hydrocephalus 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 06/11/04
Route: GAVAGE WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 08:45:25
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Casts Protein 2 [1.0] 5 [1.0] 2 [1.0]
Hydronephrosis 1 [2.0]
Nephropathy 8 [1.0] 9 [1.0] 8 [1.0] 8 [1.1]
Renal Tubule, Degeneration 4 [1.3]
Renal Tubule, Vacuolization Cytoplasmic 12 [1.2] 5 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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