TDMS Study 97013-09 Pathology Tables
NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 0 MG/L
Include 002 0 MG/L
Include 003 80 MG/L
Include 004 80 MG/L
Include 005 400 MG/L
Include 006 400 MG/L
Include 007 800 MG/L
Include 008 800 MG/L
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Natural Death 3 5 5 3
Moribund Sacrifice 2 1
Survivors
Terminal Sacrifice 10 9 10 12
Animals Examined Microscopically 15 15 15 15
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ALIMENTARY SYSTEM
Intestine Large, Rectum (1)
Anus, Squamous Cell Papilloma 1 (100%)
Liver (15) (15) (15) (15)
Salivary Glands (1)
Carcinoma 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 5 (33%) 2 (13%) 3 (20%)
Squamous Cell Papilloma, Multiple 1 (7%) 1 (7%) 2 (13%) 3 (20%)
Tooth (1) (3) (2) (4)
Odontogenic Tumor 1 (100%) 2 (67%) 2 (100%) 4 (100%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Adrenal Medulla (15) (15) (15) (15)
Pituitary Gland (15) (15) (15) (15)
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GENERAL BODY SYSTEM
None
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NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (14) (15)
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HEMATOPOIETIC SYSTEM
Lymph Node (1) (1) (3)
Lymph Node, Mandibular (15) (15) (15) (15)
Lymph Node, Mesenteric (15) (15) (14) (14)
Spleen (15) (15) (15) (15)
Thymus (15) (15) (15) (15)
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INTEGUMENTARY SYSTEM
Skin (6) (5) (2) (7)
Squamous Cell Papilloma 5 (83%) 2 (40%) 1 (50%) 4 (57%)
Squamous Cell Papilloma, Multiple 1 (17%) 1 (20%) 1 (14%)
Vulva, Squamous Cell Papilloma 1 (20%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 1 (7%) 2 (13%)
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SPECIAL SENSES SYSTEM
None
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NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
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SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%) 2 (13%) 3 (20%) 1 (7%)
Lymphoma Malignant 1 (7%) 1 (7%) 1 (7%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 8 7 10
Total Primary Neoplasms 17 12 10 18
Total Animals with Benign Neoplasms 9 5 4 9
Total Benign Neoplasms 13 7 4 13
Total Animals with Malignant Neoplasms 3 3 4 1
Total Malignant Neoplasms 3 3 4 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2 2 4
Total Uncertain Neoplasms 1 2 2 4
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Natural Death 2 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 13 13 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 3 (20%) 2 (13%) 8 (53%) 3 (20%)
Squamous Cell Papilloma, Multiple 4 (27%)
Tooth (3) (3) (4) (1)
Odontogenic Tumor 3 (100%) 3 (100%) 4 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (2) (4) (3)
Squamous Cell Papilloma 2 (100%) 3 (75%) 2 (67%)
Subcutaneous Tissue, Fibrosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 2 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
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NTP Experiment-Test: 97013-09 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 11:05:16
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 8 6 11 7
Total Primary Neoplasms 10 7 15 9
Total Animals with Benign Neoplasms 7 4 8 5
Total Benign Neoplasms 7 4 11 7
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 3 3 4 1
Total Uncertain Neoplasms 3 3 4 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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