TDMS Study 97013-10 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 06/18/04
EXPERIMENT: 97013 TEST: 10 TIME: 08:48:00
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK ROUTE: DOSED WATER NTP: C97013A
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BATTELLE COLUMBUS WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 06/18/04
EXPERIMENT: 97013 TEST: 10 TIME: 8:54:47
TEST TYPE: SUBCHRONIC (26-WEEK) ROUTE: DOSED WATER NTP: 97013A
CONT: N01-ES-65406 CAS: 7789-38-0
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)
==================================================================================================================================
0 MG/L 80 MG/L 400 MG/L 800 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 3.6 25.0 3.6 25.7 1.00 11 3.3 25.6 0.92 52 3.4 24.6 0.94 110
3 3.6 26.2 3.5 26.8 0.97 10 3.4 27.0 0.94 50 3.2 25.9 0.89 100
5 3.7 28.4 3.7 29.3 1.00 10 3.5 29.5 0.95 47 3.4 28.2 0.92 97
6 3.5 29.7 3.4 30.9 0.97 9 3.4 31.1 0.97 44 3.2 29.6 0.91 87
7 3.7 31.3 3.7 32.8 1.00 9 3.6 32.7 0.97 44 3.3 30.9 0.89 86
8 3.7 32.2 3.5 33.8 0.95 8 3.4 34.2 0.92 40 3.3 31.8 0.89 82
9 4.0 33.5 3.8 34.9 0.95 9 3.7 35.4 0.93 42 3.5 33.3 0.88 84
10 3.8 35.1 3.5 36.4 0.92 8 3.5 36.7 0.92 38 3.1 34.5 0.82 73
11 3.9 36.4 3.5 37.7 0.90 8 3.6 37.9 0.92 38 3.2 35.5 0.82 72
12 4.1 37.7 3.6 38.9 0.88 7 3.6 39.1 0.88 37 3.2 36.4 0.78 70
13 4.1 38.7 3.6 40.0 0.88 7 3.7 39.9 0.90 37 3.3 37.4 0.80 70
14 4.0 39.9 3.5 40.9 0.88 7 3.5 40.1 0.88 35 3.2 38.0 0.80 68
15 4.1 41.2 3.5 42.2 0.85 7 3.5 41.3 0.85 34 3.2 38.8 0.78 67
16 4.2 41.6 3.7 43.0 0.88 7 3.7 41.6 0.88 36 3.3 39.0 0.79 67
17 4.1 42.2 3.9 43.3 0.95 7 3.7 42.2 0.90 35 3.2 40.7 0.78 62
18 4.2 43.1 3.9 44.9 0.93 7 3.8 42.9 0.90 36 3.4 41.5 0.81 66
19 4.1 43.6 3.6 44.9 0.88 6 3.7 43.3 0.90 34 3.2 42.0 0.78 61
20 4.2 44.0 3.9 45.1 0.93 7 3.8 45.4 0.90 33 3.4 42.6 0.81 63
21 4.1 44.4 3.6 45.7 0.88 6 4.1 45.8 1.00 36 3.3 42.8 0.80 62
22 4.3 44.5 3.9 46.6 0.91 7 3.9 46.1 0.91 34 3.5 43.7 0.81 64
23 4.3 45.3 3.8 47.4 0.88 6 3.9 46.4 0.91 34 3.2 44.4 0.74 57
24 4.2 45.6 3.9 47.6 0.93 7 4.2 46.8 1.00 36 3.4 45.1 0.81 60
25 3.9 46.3 3.7 48.0 0.95 6 4.0 47.4 1.03 34 3.1 45.7 0.79 54
26 4.4 46.5 4.1 48.1 0.93 7 3.9 47.2 0.89 33 3.4 45.5 0.77 60
1 TO 13 WEEKS
----------------
MEAN 3.8 32.2 3.6 33.4 0.95 9 3.5 33.6 0.93 43 3.3 31.6 0.87 85
SD(D) 0.2 0.1 0.05 1 0.1 0.03 5 0.1 0.05 13
CV(E) 5.7 3.3 5.0 15.0 3.4 3.0 12.8 3.4 6.2 15.8
14 TO 52 WEEKS
----------------
MEAN 4.2 43.7 3.8 45.2 0.91 7 3.8 44.3 0.92 35 3.3 42.3 0.79 62
SD(D) 0.1 0.2 0.03 0 0.2 0.05 1 0.1 0.02 4
CV(E) 3.3 4.7 3.6 4.7 5.7 5.8 3.0 3.5 2.5 6.5
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)
==================================================================================================================================
0 MG/L 80 MG/L 400 MG/L 800 MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 4.0 20.8 3.9 20.5 0.98 15 4.0 20.3 1.00 79 3.9 20.4 0.98 154
3 4.3 21.4 3.9 21.2 0.91 15 4.0 21.1 0.93 77 3.9 21.0 0.91 148
5 4.5 22.6 4.4 22.3 0.98 16 4.5 21.7 1.00 82 4.3 22.1 0.96 156
6 4.6 23.0 4.0 22.8 0.87 14 4.1 22.2 0.89 75 4.2 22.4 0.91 148
7 4.3 23.8 4.1 23.4 0.95 14 4.3 22.7 1.00 75 4.1 23.1 0.95 142
8 4.6 24.2 4.3 23.8 0.93 14 4.1 22.9 0.89 72 4.4 23.1 0.96 153
9 4.8 24.9 4.2 24.4 0.88 14 4.6 23.5 0.96 78 4.3 23.4 0.90 148
10 4.6 25.6 3.9 25.2 0.85 12 4.3 24.2 0.93 72 3.8 24.0 0.83 128
11 4.9 26.2 3.9 25.5 0.80 12 4.4 24.3 0.90 72 4.2 24.0 0.86 141
12 4.9 26.2 4.2 26.0 0.86 13 4.6 24.8 0.94 74 4.6 24.2 0.94 152
13 4.8 27.4 4.4 26.9 0.92 13 4.8 24.8 1.00 77 4.6 24.6 0.96 148
14 4.6 28.0 4.3 27.1 0.93 13 4.8 25.9 1.04 75 4.4 25.1 0.96 141
15 4.6 28.4 4.2 27.6 0.91 12 4.9 26.4 1.07 73 4.7 25.5 1.02 147
16 4.9 29.3 4.3 28.4 0.88 12 4.5 26.9 0.92 67 4.4 26.1 0.90 135
17 4.6 30.4 4.1 29.2 0.89 11 4.7 27.5 1.02 69 4.2 26.8 0.91 124
18 4.5 30.2 4.3 28.9 0.96 12 4.6 27.7 1.02 67 4.2 27.0 0.93 126
19 4.6 30.5 4.1 28.8 0.89 11 4.1 28.0 0.89 59 4.5 27.0 0.98 133
20 4.7 30.8 4.5 29.7 0.96 12 4.6 28.5 0.98 65 4.4 27.2 0.94 128
21 4.5 31.3 4.2 30.3 0.93 11 4.7 29.0 1.04 65 4.4 27.5 0.98 128
22 4.7 31.3 4.4 31.0 0.94 11 4.8 30.1 1.02 64 4.4 28.4 0.94 123
23 4.4 32.4 4.0 31.9 0.91 10 4.6 31.1 1.05 59 3.8 29.6 0.86 102
24 4.3 32.8 4.5 33.0 1.05 11 4.5 31.8 1.05 57 3.8 29.3 0.88 104
25 4.3 33.6 4.2 33.8 0.98 10 4.4 32.6 1.02 54 3.9 29.9 0.91 104
26 4.5 34.3 4.1 33.7 0.91 10 4.7 33.2 1.04 56 4.2 30.3 0.93 111
1 TO 13 WEEKS
----------------
MEAN 4.6 24.2 4.1 23.8 0.90 14 4.3 23.0 0.95 76 4.2 22.9 0.92 147
SD(D) 0.3 0.2 0.06 1 0.2 0.05 3 0.3 0.05 8
CV(E) 6.1 4.7 6.4 8.0 5.7 4.8 4.5 6.2 5.1 5.4
14 TO 52 WEEKS
----------------
MEAN 4.5 31.0 4.2 30.3 0.93 11 4.6 29.1 1.01 64 4.2 27.7 0.93 124
SD(D) 0.2 0.2 0.04 1 0.2 0.05 6 0.3 0.04 14
CV(E) 3.8 3.8 4.8 8.3 4.3 5.2 10.2 6.5 4.6 11.6
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)
=========================================================================================================
0 MG/L 80 MG/L 400 MG/L 800 MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 24.2 15 24.8 15 24.8 15 24.6 15
1 24.2 15 24.8 15 24.8 15 24.6 15
2 3.6 2450 25.0 15 3.6 2470 25.7 15 3.3 2455 25.6 15 3.4 2461 24.6 15
3 3.6 4305 26.2 15 3.5 4285 26.8 15 3.4 4305 27.0 15 3.2 4305 25.9 15
4 3.6 750 27.2 15 3.6 760 27.7 15 3.2 760 28.0 15 3.2 705 26.5 15
5 3.7 2540 28.4 15 3.7 2530 29.3 15 3.5 2530 29.5 15 3.4 2540 28.2 15
6 3.5 2535 29.7 15 3.4 2505 30.9 15 3.4 2520 31.1 15 3.2 2505 29.6 15
7 3.7 2510 31.3 15 3.7 2539 32.8 15 3.6 2530 32.7 15 3.3 2545 30.9 15
8 3.7 2525 32.2 15 3.5 2535 33.8 15 3.4 2530 34.2 15 3.3 2535 31.8 15
9 4.0 2482 33.5 15 3.8 2450 34.9 15 3.7 2466 35.4 15 3.5 2442 33.3 15
10 3.8 2520 35.1 15 3.5 2525 36.4 15 3.5 2520 36.7 15 3.1 2518 34.5 15
11 3.9 2515 36.4 15 3.5 2304 37.7 15 3.6 2525 37.9 15 3.2 2535 35.5 15
12 4.1 2171 37.7 15 3.6 2144 38.9 15 3.6 2500 39.1 15 3.2 2338 36.4 15
13 4.1 2520 38.7 15 3.6 2520 40.0 15 3.7 2520 39.9 15 3.3 2520 37.4 15
14 4.0 2540 39.9 15 3.5 2516 40.9 15 3.5 2531 40.1 15 3.2 2536 38.0 15
15 4.1 3280 41.2 15 3.5 3280 42.2 15 3.5 3275 41.3 15 3.2 3221 38.8 15
16 4.2 1785 41.6 15 3.7 1785 43.0 15 3.7 1783 41.6 15 3.3 1904 39.0 15
17 4.1 2525 42.2 15 3.9 2325 43.3 15 3.7 2508 42.2 15 3.2 2330 40.7 14
18 4.2 2510 43.1 15 3.9 2479 44.9 15 3.8 2510 42.9 15 3.4 2334 41.5 14
19 4.1 2564 43.6 15 3.6 2595 44.9 15 3.7 2575 43.3 15 3.2 2422 42.0 14
20 4.2 2540 44.0 15 3.9 2530 45.1 15 3.8 2365 45.4 14 3.4 2370 42.6 14
21 4.1 2535 44.4 15 3.6 2535 45.7 15 4.1 2366 45.8 14 3.3 2366 42.8 14
22 4.3 2515 44.5 15 3.9 2342 46.6 14 3.9 2340 46.1 14 3.5 2334 43.7 14
23 4.3 2480 45.3 15 3.8 2147 47.4 14 3.9 2313 46.4 14 3.2 2323 44.4 14
24 4.2 2510 45.6 15 3.9 2347 47.6 14 4.2 2343 46.8 14 3.4 2343 45.1 14
25 3.9 2515 46.3 15 3.7 2191 48.0 14 4.0 2353 47.4 14 3.1 2348 45.7 14
26 4.4 2394 46.5 14 4.1 2380 48.1 14 3.9 2215 47.2 14 3.4 2143 45.5 14
27 4.3 2315 4.1 2038 3.8 2153 3.2 2158
MEAN BODY WGT FOR WEEKS
1 TO 13 31.2 32.3 32.5 30.7
14 TO 52 43.7 45.2 44.3 42.3
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)
=========================================================================================================
0 MG/L 80 MG/L 400 MG/L 800 MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 20.1 15 19.9 15 19.6 15 19.9 15
1 20.1 15 19.9 15 19.6 15 19.9 15
2 4.0 2387 20.8 15 3.9 2460 20.5 15 4.0 2296 20.3 15 3.9 2460 20.4 15
3 4.3 3789 21.4 15 3.9 4295 21.2 15 4.0 4300 21.1 15 3.9 4295 21.0 15
4 4.5 755 22.3 15 3.9 755 21.9 15 4.0 708 21.3 15 4.1 765 21.6 15
5 4.5 2535 22.6 15 4.4 2535 22.3 15 4.5 2520 21.7 15 4.3 2520 22.1 15
6 4.6 2360 23.0 15 4.0 2520 22.8 15 4.1 2536 22.2 15 4.2 2346 22.4 15
7 4.3 2340 23.8 15 4.1 2520 23.4 15 4.3 2515 22.7 15 4.1 2525 23.1 15
8 4.6 2525 24.2 15 4.3 2525 23.8 15 4.1 2525 22.9 15 4.4 2357 23.1 15
9 4.8 2491 24.9 15 4.2 2305 24.4 15 4.6 2491 23.5 15 4.3 2481 23.4 15
10 4.6 2352 25.6 15 3.9 2357 25.2 15 4.3 2515 24.2 15 3.8 2520 24.0 15
11 4.9 2341 26.2 15 3.9 2250 25.5 15 4.4 2346 24.3 15 4.2 2520 24.0 15
12 4.9 1844 26.2 15 4.2 1915 26.0 15 4.6 2374 24.8 15 4.6 2334 24.2 15
13 4.8 2395 27.4 15 4.4 2352 26.9 15 4.8 2184 24.8 15 4.6 2520 24.6 15
14 4.6 2365 28.0 15 4.3 2468 27.1 15 4.8 2365 25.9 15 4.4 2530 25.1 15
15 4.6 3107 28.4 15 4.2 2984 27.6 15 4.9 2963 26.4 15 4.7 2942 25.5 15
16 4.9 1779 29.3 15 4.3 1662 28.4 15 4.5 1543 26.9 15 4.4 1785 26.1 15
17 4.6 2350 30.4 15 4.1 2510 29.2 15 4.7 2519 27.5 15 4.2 2327 26.8 15
18 4.5 2520 30.2 15 4.3 2341 28.9 15 4.6 2520 27.7 15 4.2 2520 27.0 15
19 4.6 2391 30.5 15 4.1 2407 28.8 15 4.1 2391 28.0 15 4.5 2406 27.0 14
20 4.7 2361 30.8 15 4.5 2386 29.7 15 4.6 2530 28.5 15 4.4 2356 27.2 14
21 4.5 2535 31.3 15 4.2 2197 30.3 15 4.7 2366 29.0 15 4.4 2366 27.5 14
22 4.7 2180 31.3 15 4.4 2342 31.0 15 4.8 2511 30.1 15 4.4 2348 28.4 14
23 4.4 2142 32.4 14 4.0 2480 31.9 15 4.6 2470 31.1 15 3.8 2300 29.6 14
24 4.3 2176 32.8 14 4.5 2510 33.0 15 4.5 2515 31.8 15 3.8 2348 29.3 14
25 4.3 2189 33.6 14 4.2 2523 33.8 15 4.4 2525 32.6 15 3.9 2362 29.9 14
26 4.5 2161 34.3 14 4.1 2047 33.7 15 4.7 2213 33.2 15 4.2 2379 30.3 14
27 4.2 2149 4.2 2059 4.3 2194 3.9 1916
MEAN BODY WGT FOR WEEKS
1 TO 13 23.7 23.4 22.6 22.6
14 TO 52 31.0 30.3 29.1 27.7
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.