TDMS Study 97013-10 Pathology Tables
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 09:06:18
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 09:06:18
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1 1
Survivors
Terminal Sacrifice 14 15 15 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (15) (15) (15) (15)
Diverticulum 1 (7%)
Liver (15) (15) (15) (15)
Angiectasis 1 (7%)
Hematopoietic Cell Proliferation 1 (7%)
Inflammation, Chronic Active 14 (93%) 13 (87%) 14 (93%) 14 (93%)
Hepatocyte, Fatty Change 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 13 (87%) 14 (93%) 12 (80%) 12 (80%)
Stomach, Forestomach (15) (15) (15) (15)
Inflammation 1 (7%)
Inflammation, Chronic Active 1 (7%)
Epithelium, Hyperplasia 4 (27%) 1 (7%) 2 (13%) 2 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 (7%)
Subcapsular, Hyperplasia 13 (87%) 12 (80%) 13 (87%) 14 (93%)
Parathyroid Gland (1) (1)
Cyst 1 (100%) 1 (100%)
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 1 (7%)
Pars Distalis, Hyperplasia 1 (7%) 1 (7%)
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 (7%) 2 (13%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 09:06:18
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 (7%) 2 (13%)
Follicle, Depletion Secretory 2 (13%)
Follicular Cell, Hypertrophy 2 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 1 (7%) 1 (7%) 2 (13%) 1 (7%)
Uterus (15) (15) (15) (15)
Inflammation, Suppurative 1 (7%) 1 (7%)
Endometrium, Hyperplasia, Cystic 11 (73%) 10 (67%) 10 (67%) 10 (67%)
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HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 2 (13%) 1 (7%) 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 2 (13%) 1 (7%)
Thymus (15) (15) (15) (15)
Atrophy 1 (7%)
Cyst 4 (27%) 7 (47%) 12 (80%) 3 (20%)
Ectopic Parathyroid Gland 2 (13%) 1 (7%) 2 (13%)
Ectopic Thyroid 2 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 09:06:18
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Hydronephrosis 1 (7%)
Nephropathy 2 (13%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 09:06:18
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1 1
Moribund Sacrifice 1 1
Survivors
Terminal Sacrifice 14 14 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%)
Inflammation, Chronic Active 12 (80%) 12 (80%) 10 (67%) 14 (93%)
Hepatocyte, Fatty Change 10 (67%) 13 (87%) 10 (67%) 8 (53%)
Hepatocyte, Vacuolization Cytoplasmic 13 (87%) 14 (93%) 12 (80%) 14 (93%)
Stomach, Forestomach (15) (15) (15) (14)
Epithelium, Hyperplasia 3 (20%) 3 (20%) 1 (7%) 3 (21%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (14) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 (7%)
Hypertrophy 1 (7%) 2 (13%)
Subcapsular, Hyperplasia 1 (7%) 2 (13%) 2 (13%) 3 (20%)
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 4 (27%) 1 (7%) 3 (20%) 3 (20%)
Pars Distalis, Hyperplasia 2 (13%)
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 (7%) 1 (7%)
Infiltration Cellular, Lymphocyte 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 09:06:18
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 1 (7%)
Granuloma Sperm 1 (7%)
Testes (15) (15) (15) (15)
Cyst 1 (7%)
Mineralization 1 (7%)
Germinal Epithelium, Degeneration 6 (40%) 3 (20%) 3 (20%) 2 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 (7%) 2 (13%) 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%) 1 (7%)
Thymus (14) (15) (15) (15)
Cyst 7 (50%) 6 (40%) 2 (13%) 2 (13%)
Ectopic Parathyroid Gland 1 (7%)
Ectopic Thyroid 1 (7%)
Hyperplasia, Lymphoid 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-10 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04
Route: DOSED WATER Time: 09:06:18
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 5 (33%) 7 (47%) 3 (20%) 3 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
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