TDMS Study 97013-11 Pathology Tables
NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 7789-38-0 Lock Date: 07/30/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 001 0 MG/KG Include 002 0 MG/KG Include 003 64 MG/KG Include 004 64 MG/KG Include 005 128 MG/KG Include 006 128 MG/KG Include 007 256 MG/KG Include 008 256 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 Early Deaths Moribund Sacrifice 2 4 1 3 Natural Death 2 1 3 1 Survivors Terminal Sacrifice 11 10 11 11 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Stomach, Forestomach (15) (15) (15) (15) Squamous Cell Papilloma 3 (20%) 3 (20%) 3 (20%) 5 (33%) Squamous Cell Papilloma, Multiple 3 (20%) 3 (20%) 4 (27%) 3 (20%) Tooth (3) (2) (5) (4) Odontogenic Tumor 3 (100%) 2 (100%) 4 (80%) 4 (100%) Odontogenic Tumor, Multiple 1 (20%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Adrenal Medulla (15) (15) (15) (15) Pituitary Gland (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) (15) (15) Luteoma 1 (7%) Teratoma Malignant 1 (7%) Uterus (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (2) (2) Lymph Node, Mandibular (15) (14) (14) (15) Lymph Node, Mesenteric (14) (14) (13) (15) Spleen (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (15) Squamous Cell Papilloma 2 (13%) 3 (20%) 4 (27%) 5 (33%) Squamous Cell Papilloma, Multiple 3 (20%) 4 (27%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) Squamous Cell Papilloma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) Leukemia Erythrocytic 2 (13%) 1 (7%) 2 (13%) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 9 12 12 14 Total Primary Neoplasms 14 14 18 25 Total Animals with Benign Neoplasms 8 9 8 11 Total Benign Neoplasms 11 10 11 18 Total Animals with Malignant Neoplasms 2 2 3 Total Malignant Neoplasms 2 2 3 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 3 2 5 4 Total Uncertain Neoplasms 3 2 5 4 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 Early Deaths Moribund Sacrifice 2 1 Natural Death 1 3 2 Survivors Terminal Sacrifice 12 11 13 15 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Stomach, Forestomach (15) (15) (15) (15) Squamous Cell Papilloma 1 (7%) 4 (27%) 4 (27%) 3 (20%) Squamous Cell Papilloma, Multiple 2 (13%) 2 (13%) 2 (13%) 4 (27%) Tooth (3) (1) (1) (3) Odontogenic Tumor 3 (100%) 1 (100%) 1 (100%) 3 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Adrenal Medulla (15) (15) (15) (15) Pituitary Gland (15) (14) (15) (15) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Lymph Node, Mandibular (15) (15) (15) (15) Lymph Node, Mesenteric (15) (15) (15) (15) Spleen (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (15) Squamous Cell Papilloma 2 (13%) 3 (20%) 1 (7%) 4 (27%) Squamous Cell Papilloma, Multiple 1 (7%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) Leukemia Erythrocytic 2 (13%) 1 (7%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 8 NTP Experiment-Test: 97013-11 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 06/18/04 Route: SKIN APPLICATION Time: 09:17:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 6 9 9 11 Total Primary Neoplasms 8 12 10 14 Total Animals with Benign Neoplasms 4 8 7 10 Total Benign Neoplasms 5 9 8 11 Total Animals with Malignant Neoplasms 2 1 Total Malignant Neoplasms 2 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 3 1 1 3 Total Uncertain Neoplasms 3 1 1 3 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------