TDMS Study 97013-98 Pathology Tables
NTP Experiment-Test: 97013-98 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:04:54
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-98 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:04:54
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 1
Moribund Sacrifice 1 1 1
Dosing Accident 1
Survivors
Terminal Sacrifice 9 9 8 9
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Perforation 1 (100%)
Liver (10) (10) (10) (10)
Infiltration Cellular, Lymphocyte 3 (30%) 2 (20%) 3 (30%)
Inflammation 6 (60%) 10 (100%) 7 (70%) 8 (80%)
Necrosis 2 (20%) 1 (10%)
Hepatocyte, Fatty Change 3 (30%) 3 (30%) 6 (60%) 9 (90%)
Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 10 (100%) 9 (90%) 10 (100%)
Mesentery (1)
Inflammation, Suppurative 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Subcapsular, Hyperplasia 10 (100%) 9 (90%) 9 (90%) 10 (100%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (10) (10) (10) (10)
Cyst 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Inflammation 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-98 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:04:54
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%)
Cyst 3 (30%) 1 (10%)
Oviduct (2) (1)
Infiltration Cellular, Lymphocyte 2 (100%) 1 (100%)
Uterus (10) (10) (10) (10)
Inflammation 2 (20%) 2 (20%) 1 (10%) 1 (10%)
Endometrium, Hyperplasia, Cystic 9 (90%) 8 (80%) 8 (80%) 10 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia 1 (10%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%) 1 (10%)
Thymus (9) (10) (10) (10)
Atrophy 1 (11%) 2 (20%) 2 (20%) 1 (10%)
Cyst 6 (67%) 8 (80%) 8 (80%) 8 (80%)
Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-98 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:04:54
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%) 2 (20%) 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Accumulation, Hyaline Droplet 1 (10%)
Casts Protein 7 (70%) 4 (40%) 6 (60%) 6 (60%)
Mineralization 1 (10%)
Nephropathy 2 (20%) 3 (30%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-98 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:04:54
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 10 9 10 10
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Infiltration Cellular, Lymphocyte 2 (20%) 3 (30%) 1 (10%) 3 (30%)
Inflammation 7 (70%) 9 (90%) 9 (90%) 9 (90%)
Necrosis 1 (10%)
Hepatocyte, Fatty Change 6 (60%) 6 (60%) 5 (50%) 10 (100%)
Hepatocyte, Vacuolization Cytoplasmic 10 (100%) 9 (90%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 3 (30%) 2 (20%) 2 (20%) 1 (10%)
Subcapsular, Hyperplasia 2 (20%) 1 (10%) 2 (20%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (10) (10) (10) (10)
Cyst 4 (40%) 2 (20%) 3 (30%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-98 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:04:54
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%) 1 (10%)
Inflammation 1 (10%)
Testes (10) (10) (10) (10)
Mineralization 2 (20%) 1 (10%)
Germinal Epithelium, Degeneration 2 (20%) 5 (50%) 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (9) (10) (10) (10)
Infiltration Cellular, Polymorphonuclear 1 (10%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Thymus (9) (10) (9) (10)
Cyst 6 (67%) 7 (70%) 6 (67%) 4 (40%)
Epithelial Cell, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%) 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-98 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 11/04/03
Route: GAVAGE Time: 12:04:54
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/KG 25 MG/KG 50 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 1 (10%) 2 (20%)
Cyst 1 (10%)
Mineralization 1 (10%)
Nephropathy 4 (40%) 3 (30%) 4 (40%) 9 (90%)
Renal Tubule, Degeneration 1 (10%) 10 (100%)
Renal Tubule, Dilatation 1 (10%)
Renal Tubule, Vacuolization Cytoplasmic 8 (80%) 5 (50%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------