5,5-Diphenylhydantoin (phenytoin): Target Organs and Levels of Evidence for TR-404
Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) (CASRN 57-41-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
Chemical (Study Title) CASRN | Peer Review Date | Route/Exposure Levels | Study Laboratory |
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5,5-Diphenylhydantoin (phenytoin) 57-41-0 | 06/24/1992 | Dosed-Feed R: 0,240,800,2400, MM: 0,30,100,300, FM: 0,60,200,600 PPM/50 PER GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
Type | Organ/Tissue (Lesion) |
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Neoplastic Lesions | - Liver:
ADENOMA 0/50 1/50 4/50; CARCINOMA 0/50 1/50 0/50
|
Non-Neoplastic Lesions | - LIVER: CENTRILOBULAR HYPERTROPHY
|
Other Considerations | - LIVER: BASOPHILIC FOCUS 17/50 15/50 4/50
|
Female Rats: No Evidence
Type | Organ/Tissue (Lesion) |
---|
Non-Neoplastic Lesions | - LIVER: CENTRILOBULAR HYPERTROPHY
|
Other Considerations | - LIVER: BASOPHILIC FOCUS 40/50 33/50 6/50
|
Male Mice: No Evidence
Female Mice: Clear Evidence
Type | Organ/Tissue (Lesion) |
---|
Neoplastic Lesions | - Liver:
ADENOMA 5/48 13/49 22/50, HEPATOBLASTOMA OR CARCINOMA 0/48 1/49 12/50, COMBINED 5/48 14/49 30/50
|
Non-Neoplastic Lesions | - LIVER: CENTRILOBULAR HYPERTROPHY
|