Integrated Chemical Environment Training 2024
May 22, 2024
Natcher Conference Center, National Institutes of Health, Bethesda, MD
View slides presented at the training.
NICEATM hosted a training session focused on the Integrated Chemical Environment (ICE), including opportunities to learn about its latest updates. ICE is a globally used platform that provides user-friendly access to high-quality data and tools to support the evaluation of chemical toxicity. This training provided a general overview of ICE, its data and curated chemical lists, and live demonstrations of different ICE tools, including:
- Search Tool – Explore toxicological endpoints, chemical properties, and exposure data for chemicals and mixtures of interest.
- Chemical Quest Tool - Identify structurally similar chemicals.
- Chemical Characterization Tool - Compare chemical properties and chemical use categories.
- Curve Surfer Tool - Explore concentration-response curves and bioactivity with curated high-throughput screening data.
- PBPK Tool - Predict tissue-specific chemical concentration profiles following a dosing event.
- IVIVE Tool - Estimate the in vivo equivalent administered dose from in vitro data.
Agenda
| Time (EDT) | Topic |
|---|---|
| 1:00-1:50 p.m. | Introduction to ICE Data Sets and Curated Chemical Lists in ICE Search Tool: explore toxicological endpoints, chemical properties, and exposure data for chemicals and mixtures of interest |
| 1:50-2:00 p.m. | Break |
| 2:00-2:50 p.m. | Chemical Quest Tool: identify structurally similar chemicals Chemical Characterization Tool: compare chemical properties and chemical use categories Curve Surfer Tool: explore concentration-response curves and bioactivity with curated high-throughput screening data |
| 2:50-3:00 p.m. | Break |
| 3:00-3:50 p.m. | PBPK Tool: predict tissue-specific chemical concentration profiles following a dosing event IVIVE Tool: estimate the in vivo equivalent administered dose from in vitro data Q&A |