About this Report
The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) facilitates the development, validation, and regulatory acceptance of test methods that replace, reduce, or refine the use of animals in testing.
The ICCVAM Authorization Act of 2000 directed ICCVAM to prepare a progress report on its first anniversary and biennially thereafter. This 2022-2023 biennial report summarizes progress by ICCVAM agencies toward encouraging the development, utilization, and building of confidence in new methods as set forth in the 2018 ICCVAM report, A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States. The text is not copyrighted and can be reprinted without permission. If you use any part of the Biennial Report in a publication, please provide NICEATM a copy for our records.
Please cite this document as follows:
ICCVAM. 2022. Biennial Progress Report 2022-2023. Research Triangle Park (NC): National Institute of Environmental Health Sciences. Available: https://ntp.niehs.nih.gov/iccvamreport/2023. https://doi.org/10.22427/NICEATM-4.
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NICEATM Director: Nicole Kleinstreuer
NICEATM Project Officer/Contracting Officer’s Representative: Pei-Li Yao
Report Editor: Catherine Sprankle
The ICCVAM Biennial Report was prepared by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), with support from the Office of Policy, Review, and Outreach of the National Institute of Environmental Health Sciences Division of Translational Toxicology. Preparation of this report was supported by the Intramural Research Program (ES IR #1 ZIC ES103386-01) at the National Institute of Environmental Health Sciences and work conducted under contract HHSN273201500010C.