ICCVAM Biennial Report 2022-2023

ICCVAM. 2022. Biennial Progress Report 2020-2021 [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences. Available: https://ntp.niehs.nih.gov/iccvamreport/2021/index.html.

All Federal Register notices issued by NICEATM can be found on the NTP website at http://ntp.niehs.nih.gov/go/frn.

NIEHS. 2022. ICCVAM notice of public webinar; request for public input. Federal Register. 87(84): 25649-25650. NIEHS. 2022. ICCVAM Biennial Progress Report: 2020-2021; availability of report. Federal Register. 87(185): 58363-58364.

NIEHS. 2023. ICCVAM Communities of Practice webinar on emerging approaches for anchoring biological relevance of new approach methodologies. Federal Register. 88(5): 1240-1241.

NIEHS. 2023. ICCVAM notice of public meeting; request for public input. Federal Register. 88(70): 22050-22051.

NIEHS. 2023. ICCVAM request for comment on draft report on validation, qualification, and acceptance of new approach methodologies. Federal Register. 88(153): 54342.

A full list of NICEATM and ICCVAM publications is available on the NTP website.

Baran SW, Brown PC, Baudy AR, Fitzpatrick SC, Frantz C, Fullerton A, Gan J, Hardwick RN, Hillgren KM, Kopec AK, Liras JL, Mendrick DL, Nagao R, Proctor WR, Ramsden D, Ribeiro AJS, Stresser D, Sung KE, Sura R, Tetsuka K, Tomlinson L, Van Vleet T, Wagoner MP, Wang Q, Arslan SY, Yoder G, Ekert JE. 2022. Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate). ALTEX 39(2):297-314. https://doi.org/10.14573/altex.2112203.

Bishop PL, Brescia S, Brunner R, Casey W, Conlee-Griffin K, Currie RA, Domoradzki J, Embry M, Harris MI, Hartung T, Hilton GM, Hooberman B, Ingle B, Jang KJ, Kinter L, Krall C, Leedale J, Lowit A, Mehta J, Mendez E, Mingoia B, Munarriz E, Murphy L, Myer A, Ottoni A, Panzarea M, Perron M, Pina J, Ramsingh D, Sewell F, Swanson J, Tan YM, Terron A, Trainer MA, Valadares MC, Webb S, Webb E, Willett C, Wolf DC. 2023. Challenges and opportunities for overcoming dog use in agrochemical evaluation and registration. ALTEX 40(3):534-540. https://doi.org/10.14573/altex.2302151.

Borba JVB, Alves VM, Braga RC, Korn DR, Overdahl K, Silva AC, Hall SUS, Overdahl E, Kleinstreuer N, Strickland J, Allen D, Andrada CH, Muratov EN, Tropsha A. 2022. STopTox: An in silico alternative to animal testing for acute systemic and topical toxicity. Environ Health Perspect 130(2):027012. https://doi.org/10.1289/EHP9341.

Borrel A, Conway M, Nolte SZ, Unnikrishnan A, Schmitt CP, Kleinstreuer NC. 2023. ChemMaps.com v2.0: exploring the environmental chemical universe. Nucleic Acids Res 51(W1):W78-W82. https://doi.org/10.1093/nar/gkad380.

Carlson JM, Janulewicz PA, Kleinstreuer NC, Heiger-Bernays W. 2022. Impact of high-throughput model parameterization and data uncertainty on thyroid-based toxicological estimates for pesticide chemicals. Environ Sci Technol 56(9):5620-5631. https://doi.org/10.1021/acs.est.1c07143.

Ceger P, Allen D, Blankinship A, Choksi N, Daniel A, Eckel WP, Hamm J, Harwood DE, Johnson T, Kleinstreuer N, Sprankle CS, Truax J, Lowit M. 2023. Evaluation of the fish acute toxicity test for pesticide registration. Reg Toxicol Pharmacol 139:105340. https://doi.org/10.1016/j.yrtph.2023.105340.

Ceger P, Garcia-Reyero Vinas N, Allen D, Arnold E, Bloom R, Brennan JC, Clarke C, Eisenreich K, Fay K, Hamm J, Henry PFP, Horak K, Hunter W, Judkins D, Klein P, Kleinstreuer N, Koehrn K, LaLone CA, Laurenson JP, Leet JK, Lowit A, Lynn SG, Norberg-King T, Perkins EJ, Petersen EJ, Rattner BA, Sprankle CS, Steeger T, Warren JE, Winfield S, Odenkirchen E. 2022. Current ecotoxicity testing needs among selected U.S. federal agencies. Reg Toxicol Pharmacol. https://doi.org/10.1016/j.yrtph.2022.105195.

Chang X, Palmer J, Lumen A, Lee UJ, Ceger P, Mansouri K, Sprankle C, Donley E, Bell S, Knudsen TB, Wambaugh J, Cook B, Allen D, Kleinstreuer N. 2022. Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues. Birth Defects Res 114:1037-1055. https://doi.org/10.1002/bdr2.2019.
Winner, 2023 James G. Wilson Publication Award for the best paper published in Birth Defects Research in 2022.

Chang X, Tan YM, Allen DG, Bell S, Brown PC, Browning L, Ceger P, Gearhart J, Hakkinen PJ, Kabadi SV, Kleinstreuer NC, Lumen A, Matheson J, Paini A, Pangburn HA, Petersen EJ, Reinke EN, Ribeiro AJS, Sipes N, Sweeney LM, Wambaugh JF, Wange R, Wetmore BA, Mumtaz M. 2022. IVIVE: facilitating the use of in vitro toxicity data in risk assessment and decision-making. Toxics 10(5):232. https://doi.org/10.3390/toxics10050232.
Recognized by Toxics as an "Annual Recommended Review for 2022."

Corton JC, Liu J, Kleinstreuer N, Gwinn MR, Ryan N. 2022. Towards replacement of animal tests with in vitro assays: a gene expression biomarker predicts in vitro and in vivo estrogen receptor activity. Chem Biol Interact. https://doi.org/10.1016/j.cbi.2022.109995.

Daniel AB, Choksi N, Abedini J, Bell S, Ceger P, Cook B, Karmaus AL, Rooney J, To KT, Allen D, Kleinstreuer. 2022. Data curation to support toxicity assessments using the Integrated Chemical Environment. Front Toxicol. https://doi.org/10.3389/ftox.2022.987848.

Eccles KM, Karmaus AL, Kleinstreuer NC, Parham F, Rider CV, Wambaugh JF, Messier KP. 2022. A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target. Sci Total Environ. https://doi.org/10.1016/j.scitotenv.2022.158905.

Felter SP, Bhat VS, Botham PA, Bussard DA, Casey W, Hayes AW, Hilton GM, Magurany KA, Sauer UG, Ohanian EV. 2022. Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop. Crit Rev Toxicol 51(8):653-694. https://doi.org/10.1080/10408444.2021.2003295.

Feshuk M, Kolaczkowski L, Dunham K, Davidson-Fritz SE, Carstens KE, Brown J, Judson, RS, Paul Friedman K. 2023. The ToxCast pipeline: updates to curve-fitting approaches and database structure. Front Toxicol 5:1275980. https://doi.org/10.3389/ftox.2023.1275980.

Flannery BM, Turley AE, Anyangwe N, Mattia A, Whiteside C, Hermansky S, Schaefer HR, Tyler T, Fitzpatrick SC. 2023. Retrospective analysis of dog study data from food and color additive petitions. Reg Toxicol Pharmacol 145:105523. https://doi.org/10.1016/j.yrtph.2023.105523.

Golden E, Allen D, Amberg A, Anger LT, Baker E, Baran S, Bringezu F, Clark M, Duchateau-Nguyen G, Escher SE, Giri V, Grevot A, Hartung T, Li D, Lotfi L, Muster W, Snyder K, Wange R, Steger-Hartmann T. 2023. Toward implementing virtual control groups in nonclinical safety studies: workshop report and roadmap to implementation. ALTEX. https://doi.org/10.14573/altex.2310041.

Hamm J, Mahapatra D, Knuth MM, Abedini J, Lingerfelt M, Ekins S, Kullman SW. 2022. Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays. Curr Res Toxicol 3:100092. https://doi.org/10.1016/j.crtox.2022.100092.

Hilton GM, Adcock C, Akerman G, Baldassari J, Battalora M, Casey W, Clippinger AJ, Cope R, Goetz A, Hayes AW, Papineni S, Peffer RC, Ramsingh D, Riffle BW, Sanches da Rocha M, Ryan N, Scollon E, Visconti N, Wolf DC, Yan Z, Lowit A. 2022. Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassays. Regul Toxicol Pharmacol. https://doi.org/10.1016/j.yrtph.2022.105160.

Hines DE, Bell S, Chang X, Mansouri K, Allen D, Kleinstreuer N. 2022. Application of an accessible interface for pharmacokinetic modeling and in vitro to in vivo extrapolation. Front Pharmacol. https://doi.org/10.3389/fphar.2022.864742.

Hogberg HT, Lam A, Ohayon E, Shahbaz MA, Clerbaux LA, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana M. 2022. The adverse outcome pathway framework applied to neurological symptoms of COVID-19. Cells. https://www.mdpi.com/2073-4409/11/21/3411.

Hsieh JH, Nolte S, Hamm JT, Wang Z, Roberts GK, Schmitt CP, Ryan KR. 2023. Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT): Developing a data analysis pipeline for the assessment of developmental toxicity with an interlaboratory study. Toxics. 11(5):407. https://doi.org/10.3390/toxics11050407.

Jordan R, Ford-Scheimer SL, Alarcon RM, Atala A, Borenstein JT, Brimacombe KR, Cherry S, Clevers H, Davis MI, Funnell SGP, Gehrke L, Griffith LG, Grossman AC, Hartung T, Ingber DE, Kleinstreuer NC, Kuo CJ, Lee EM, Mummery CL, Pickett TC, Ramani S, Rosado-Olivieri EA, Struble EB, Wan Z, Williams MS, Hall MD, Ferrer M, Markossian S. 2023. Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development. J Inf Diseases 228(Suppl 5):S337-S354. https://doi.org/10.1093/infdis/jiad334.

Karmaus AL, Mansouri K, To KT, Blake B, Fitzpatrick J, Strickland J, Patlewicz G, Allen D, Casey W, Kleinstreuer N. 2022. Evaluation of variability across rat acute oral systemic toxicity studies. Toxicol Sci 188(1):34-47. https://doi.org/10.1093/toxsci/kfac042.

Kleinstreuer NC, Allen D. 2023. Novel approaches and alternative models: Validation and regulatory acceptance of toxicological testing methods and strategies. In: Hayes' Principles and Methods of Toxicology (7th ed). Boca Raton: CRC Press. https://doi.org/10.1201/9781003390008.

Krishna S, Borrel A, Huang R, Zhao J, Xia M, Kleinstreuer N. 2022. High-throughput chemical screening and structure-based models to predict hERG inhibition. Biology 11(2):209. https://doi.org/10.3390/biology11020209.

Lee KM, Corley R, Jarabek AM, Kleinstreuer N, Paini A, Stucki AO, Bell S. 2022. Advancing new approach methodologies (NAMs) for tobacco harm reduction: synopsis from the 2021 COREST SSPT–NAMs symposium. Toxics 10(12): 760. https://doi.org/10.3390/toxics10120760.

Lynch C, Sakamuru S, Ooka M, Huang R, Klumpp-Thomas C, Shinn P, Gerhold D, Rossoshek A, Michael S, Casey W, Santillo MF, Fitzpatrick S, Thomas RS, Simeonov A, Xia M. 2023. High-throughput screening to advance in vitro toxicology: accomplishments, challenges, and future directions. Ann Rev Pharmacol Toxicol 64:3.1-3.19. https://doi.org/10.1146/annurev-pharmtox-112122-104310.

Magurany KA, Chang X, Clewell R, Coecke S, Haugabrooks E, Marty S. 2023. A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment. Toxicol Sci. 192(2):155–77. https://doi.org/10.1093/toxsci/kfad012.

Natsch A, Kleinstreuer N, Astruriol D. 2023. Reduced specificity for the local lymph node assay for lipophilic chemicals: implications for the validation of new approach methods for skin sensitization. Reg Toxicol Pharmacol 138:10533. https://doi.org/10.1016/j.yrtph.2023.105333.

Petersen EJ, Ceger P, Allen DG, Coyle J, Derk R, Garcia-Reyero N, Gordon J, Kleinstreuer N, Matheson J, McShan D, Nelson BC, Patri AK, Rice P, Rojanasakul L, Sasidharan A, Scarano L, Chang X. 2022. U.S. federal agency interests and key considerations for new approach methodologies for nanomaterials. ALTEX 39(2):183-206. https://doi.org/10.14573/altex.2105041.

Petersen EJ, Elliott JT, Gordon J, Kleinstreuer NC, Reinke E, Rosslein M, Toman B. 2022. Technical framework for enabling high-quality measurements in new approach methodologies (NAMs). ALTEX 40(1):174-186. https://doi.org/10.14573/altex.2205081.

Petersen EJ, Uhl R, Toman B, Elliott JT, Strickland J, Truax J, Gordon J. 2022. Development of a 96-well electrophilic allergen screening assay for skin sensitization using a measurement science approach. Toxics 10(5):257. https://doi.org/10.3390/toxics10050257.

Reardon AJF, Farmahin R, Williams A, Meier MJ, Addicks GC, Yauk CL, Matteo G, Atlas E, Harrill J, Everett LJ, Shah I, Judson R, Ramaiahgari S, Ferguson SS, Barton-Maclaren TS. 2023. From vision toward best practices: Evaluating in vitro transcriptomic points of departure for application in risk assessment using a uniform workflow. Front Toxicol. https://doi.org/10.3389/ftox.2023.1194895.

Rogers B, Brown J, Allen DG, Casey W, Clippinger AJ. 2022. Replacement of in vivo leptospirosis vaccine potency testing in the United States. Biologicals 78:36-44. https://doi.org/10.1016/j.biologicals.2022.05.001.

Sakolish C, Moyer HL, Tsai HD, Ford LC, Dickey AN, Wright FA, Han G, Bajaj P, Baltazar MT, Carmichael PL, Stanko JP, Ferguson SS, Rusyn I. 2023. Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate® 3-lane 40 for in vitro studies of drug transport and toxicity. Toxicol Sci 196(1):52-70. https://doi.org/10.1093/toxsci/kfad080.

Salminen AT, Davis KJ, Felton RP, Nischal N, VonTungeln LS, Beland FA, Derr K, Brown PC, Ferrer M, Katz LM, Kleinstreuer NC, Leshin J, Manga P, Sadrieh N, Xia M, Fitzpatrick SC, Camacho L. 2023. Parallel evaluation of alternative skin barrier models and excised human skin for dermal absorption studies in vitro. Toxicol In Vitro 64(4):202-233. https://doi.org/10.1016/j.tiv.2023.105630.

Sanvido O, Basketter DA, Berthet A, Bloch D, Ezendam J, Hopf NB, Kleinstreuer N, Merolla LL, Uter W, Wiemann C, Wilks MF. 2023. Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations. Reg Toxicol Pharmacol 144:105493. https://doi.org/10.1016/j.yrtph.2023.105493.

Schmeisser S, Miccoli A, von Bergen M, Berggen E, Braeuning A, Busch W, Desaintes C, Gourmelon A, Grafstrom R, Harrill J, Hartung T, Herzler M, Kass G, Kleinstreuer N, Leist M, Luijten M, Marx-Stoelting P, Poetz O, van Ravenzwaay B, Roggeband R, Rogiers V, Roth A, Sanders P, Thomas RS, Marie Vinggaard A, Vinken M, van de Water B, Luch A, Tralau T. 2023. New approach methodologies in human regulatory toxicology - Not if, but how and when! Environ Intl 178:108082. https://doi.org/10.1016/j.envint.2023.108082.

Sedykh A, Choksi NY, Allen DG, Casey WM, Shah R, Kleinstreuer NC. 2022. Mixtures-inclusive in silico models of ocular toxicity based on United States and international hazard categories. Chem Res Toxicol 35(6):992-1000. https://doi.org/10.1021/acs.chemrestox.1c00443.

Sharma M, Stucki AO, Verstraelen S, Stedeford TJ, Jacobs A, Maes F, Poelmans D, Van Laer J, Remy S, Frijns E, Allen DG, Clippinger AJ. 2023. Human cell-based in vitro systems to assess respiratory toxicity: A case study using silanes. Toxicol Sci 195(2):213-230. https://doi.org/10.1093/toxsci/kfad074.

Smith-Roe SL, Swartz CD, Rashid A, Christy NC, Sly JE, Chang X, Sipes NS, Shockley KR, Harris SF, McBride SJ, Larson GJ, Collins BJ, Mutlu E, Witt KL. 2023. Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays. Environ Mol Mutagen 64(4):202-233. https://doi.org/10.1002/em.22534.
Noted as an Intramural paper of the Month in the NIEHS Environmental Factor, April 2023.

Strickland J, Abedini J, Allen DG, Gordon J, Hull V, Kleinstreuer NC, Ko HS, Matheson J, Thierse HJ, Truax J, Vanselow J, Herzler M. 2023. A database of human predictive patch test data for skin sensitization. Arch Toxicol 97:2825-2837. https://doi.org/10.1007/s00204-023-03530-3.

Strickland J, Haugabrooks E, Allen DG, Balottin LB, Hirabayashi Y, Kleinstreuer NC, Kojima H, Nishizawa C, Prieto P, Ratzlaff DE, Jeong J, Lee J, Yang Y, Lin P, Sullivan K, Casey W. 2023. International regulatory uses of acute systemic toxicity data and integration of new approach methodologies. Crit Rev Toxicol 53(7);385-411. https://doi.org/10.1080/10408444.2023.2240852.

Strickland J, Allen DG, Germolec D, Kleinstreuer N, Johnson VJ, Gulledge T, Truax J, Lowit A, Dole T, McMahon T, Panger M, Facey J, Savage S. 2022. Application of defined approaches to assess skin sensitization potency of isothiazolinone compounds. Appl In Vitro Toxicol 8(2)117-128. https://doi.org/10.1089/aivt.2022.0014.
Rosalind Franklin Society Award in Science awarded to Judy Strickland as first author of this paper.

Strickland J, Truax J, Corvaro M, Settivari R, Henriquez J, McFadden J, Gulledge T, Johnson V, Gehen S, Germolec DG, Allen D, Kleinstreuer N. 2022. Application of defined approaches for skin sensitization to agrochemical products. Front Toxicol. https://doi.org/10.3389/ftox.2022.852856.

Thessen AE, Marvel S, Achenbach JC, Fischer S, Haendel MA, Hayward K, Klüver N, Könemann S, Legradi J, Lein PJ, Leong C, Muriana A, Mylroie JE, Padilla S, Perone D, Planchart A, Prieto RM, Quevedo C, Reif DM, Ryan K, Stinckens E, Truong L, Vergauwen L, Vom Berg C, Wilbanks M, Yaghoobi B, Hamm J. Implementation of zebrafish ontologies for toxicology screening. Front Toxicol. https://doi.org/10.3389/ftox.2022.817999.

To KT, Kleinstreuer N, Vasiliou V, Hogberg HT. 2023. New approach methodologies to address population variability and susceptibility. Human Genomics 17:56. https://doi.org/10.1186/s40246-023-00502-7.

van der Zalm AJ, Barroso J, Browne P, Casey W, Gordon J, Henry TR, Kleinstreuer NC, Lowit AB, Perron M, Clippinger AJ. 2022. A framework for establishing scientific confidence in new approach methodologies. Arch Toxicol 96(11):2865-2879. https://doi.org/10.1007/s00204-022-03365-4.

van der Zalm AJ, Daniel AB, Raabe HA, Choksi N, Flint Silva T, Breeden-Alemi J, O'Dell L, Kleinstreuer NC, Lowit AM, Allen DG, Clippinger AJ. 2023. Defined approaches to classify agrochemical formulations into EPA hazard categories developed using EpiOcularTM reconstructed human corneal epithelium and bovine corneal opacity and permeability assays. Cut Ocular Toxicol. https://doi.org/10.1080/15569527.2023.2275029.

Vliet SMF, Markey KJ, Lynn SG, Adetona A, Fallacara D, Ceger P, Choksi N, Karmaus AL, Watson A, Ewans A, Daniel AB, Hamm J, Vitense K, Wolf KA, Thomas A, LaLone CA. 2023. Weight of evidence for cross-species conservation of androgen receptor-based biological activity. Toxicol Sci 193(2):131-145. https://doi.org/10.1093/toxsci/kfad038.

A searchable list of NICEATM and ICCVAM abstracts is available on the NTP website.

Abedini J, Cook B, McAfee E, Phillips J, Rooney J, Allen DG, Mansouri K, Kleinstreuer NC. 2022. ICE Tools to Support Chemical Evaluations [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Allen DG, Rooney J, To K, Choksi N, Ceger P, Daniel A, Karmaus AL, Strickland J, Truax J, Casey W, Kleinstreuer N. 2022. Variability in Reference Test Method Data and the Impact on NAM Evaluations [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Beardslee RA, Salazar K, van der Zalm A, Camacho IA, Brunner R, Raabe H, Allen D, Daniel A, Kleinstreuer N, O’Dell L, Clippinger A, Scarano L, Lowit A. 2023. Evaluating New Chemicals in the U.S. under the Toxic Substances Control Act (TSCA): Application of New Approach Methods (NAMs) to Evaluate Eye Irritation [Abstract]. Presented at the Annual Meeting of the Society of Toxicology, 19-23 March, 2023.

Bisson W, Mansouri K, Garner S, Arroyave W, Ewens A, Wang A, Jahnke G, Lunn R. 2022. A Potential Novel Integrative Strategy for Read-Across to Evaluate Large Numbers of Nitro-Polycyclic Aromatic Hydrocarbons (NPAHs) for Cancer Hazard Evaluation [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology; 19-21 October 2022.

Borrel A, Karmaus AL, Tedla G, Mansouri K, Luechtefeld T, Lunn R, Wang A, Allen D, Kleinstreuer N. 2023. Deep Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms [Abstract]. Presented at the 12th Annual Meeting: American Society for Cellular and Computational Toxicology, 23-25 October 2023; and the 12th World Congress on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023.

Borrel A, Unnikrishnan A, Allen D, Kleinstreuer N. 2023. ChemMaps.com v2.0 - Exploring the Environmental Chemical Universe [Abstract]. Presented at the Annual Meeting of the Society of Toxicology, 19-23 March, 2023; the 12th Annual Meeting: American Society for Cellular and Computational Toxicology, 23-25 October 2023; the Southeast Regional Meeting of the American Chemical Society, 25-28 October 2023; and the 12th World Congress on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023.

Carder J, Allen DG, Hogberg H, Oyetade O, Kleinstreuer N, Marko S. 2023. Opportunities for Encouraging the Consideration of Alternative Methods [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Chang X, Bell S, Abedini J, Allen D, Kleinstreuer N. 2022. Fit for Purpose Evaluation of In Vitro Assays for IVIVE [Abstract]. Presented at FutureTox V; 10-11 May 2022.

Chang X, Palmer J, Donley E, Reinke E, Allen D, Kleinstreuer N. 2022. In Vitro to In Vivo Extrapolation to Facilitate the Animal-free Risk Assessment of Potential Developmental Toxicants [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology; 19-21 October 2022.

Chang X, Reinke E, Daniel A, Allen DG, Kleinstreuer N, Mumtaz MM. 2023. Using In Vitro Data and PBPK Models to Predict Inhalation Toxicity [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Chang X, Reinke EN, Daniel AB, Allen DG, Mumtaz MM, Kleinstreuer NC. 2023. Combining NAM Data and IVIVE for Evaluating Potential Inhalation Toxicity [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Cook B, Abedini J, Bell S, Rooney J, McAfee E, Phillips J, Allen D, Kleinstreuer N. 2022. Providing Context for Chemical Effects Through Compound Structure Similarity [Abstract]. Presented at the American Chemical Society 2022 Spring Meeting; 20-24 March 2022.

Daniel A, Kleinstreuer N, Allen D, Blaylock M, Glover K, Goralski T, Kerr C, Tagle D, Williams M, Holmes A. 2023. A Working Group Supporting Adoption of MPS in Infectious Disease Research [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Daniel A, Kleinstreuer N, Allen D, Glover K, Goralski T, Gough B, Schurdak M, Sprankle C, Tagle D, Williams M, Holmes A. 2022. Facilitating Global Connections through the Microphysiological Systems for COVID Research (MPSCoRe) Working Group [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology; 19-21 October 2022.

Daniel A, van der Zalm A, Raabe H, Clippinger AJ, Kleinstreuer N, Allen D. 2023. Defined Approaches for GHS Categorization to Assess Eye Irritation Potential of Agrochemical Formulations [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Daniel AB, van der Zalm AJ, Clippinger AJ, Kleinstreuer NC, Allen DG. 2023. Three-Phase Testing of Agrochemical Formulations: Developing a Defined Approach for Eye Irritation Potential [Abstract 3137]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Eccles KM, Karmaus AL, Kleinstreuer NC, Parham F, Wambaugh JF, Messier KP. 2023. Mapping a Path to Disease: Quantifying the Risk of Exposure to Environmental Chemical Mixtures via a Common Molecular Target Using a Geospatial Modeling Approach [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Ehrlich D, Krishna S, Kleinstreuer N. 2022. Data-Driven Derivation of an Adverse Outcome Pathway Linking VEGF and Cardiotoxicity [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology; 19-21 October 2022.

Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Allen DG, Kleinstreuer NC, Strickland J. 2023. Validation of the Electrophilic Allergen Screening Assay (EASA) to Detect Substances That Impact the Initial Key Event in the Adverse Outcome Pathway for Skin Sensitization [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Elliott J, Gutierrez R, Johnson VJ, Germolec D, Allen DG, Kleinstreuer NC, Strickland J. 2023. Validation of the Electrophilic Allergen Screening Assay (EASA) [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer N, Ko H-S, Matheson J, Thierse H-J, Truax J, Vanselow JT, Strickland J. 2023. Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023; and the Annual Meeting of the Society of Toxicology, 19-23 March 2023.

Herzler M, To KT, Unnikrishnan A, Abedini J, Allen D, Germolec D, Gordon J, Kleinstreuer K, Ko HS, Matheson J, Thierse HJ, Truax J, Vanselow JT, Strickland J. 2023. Evaluation of Skin Sensitization Classification Rules to Reflect Induction Potency in Humans [Abstract]. Presented at the 12th Annual Meeting: American Society for Cellular and Computational Toxicology, 23-25 October 2023.

Hines D, Abedini J, Allen D, Kleinstreuer N, Mansouri K. 2022. Integrating Parameter Uncertainty in PBPK Modeling [Abstract]. Presented at FutureTox V; 10-11 May 2022.

Hines D, Cook B, Hull V, Allen D, Dorne JLCM, Erickson J, Combs P, Ferguson S, Kleinstreuer N, Mansouri K. 2022. Integrating Population Enzyme Variability Into Physiologically based Kinetic Models of Parent Chemicals and Metabolites [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology; 19-21 October 2022.

Hogberg H. 2022. Assay Gaps in the Developmental Neurotoxicity (DNT) New Approach Methodologies (NAMs) Battery for Human Health Risk Assessment [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Hogberg H. 2022. Ontogeny of Neurotransmitter Function as an Endpoint for Developmental Neurotoxicity Assessment [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Hogberg H, Behl M, Combs P, Cushman J, Erickson J, Hall L, Hsieh JH, Kendricks D, Kreutz A, Stanko J, Thomas D, Wilson L, Zhang X, Sills R, McPherson C. 2023. Generating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023.

Hogberg-Durdock H, Lam A, Elan O, Shahbaz MA, Clerbaux L, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana M. 2023. The Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19 [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Hull V, Borrel A, Karmaus AL, Allen DG, Kleinstreuer N. 2023. Integration of Technological Interference into Curated HTS Data [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Hull V, Borrel A, Karmaus AL, To K, Allen D, Kleinstreuer NC. 2022. Integration of Technological Interference into the Interpretation of Curated High-throughput Screening (cHTS) Data [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology; 19-21 October 2022.

Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JC, Erickson J, Combs P, Ferguson S, Kleinstreuer NC, Mansouri K. 2023. Integrating Population Enzyme Variability into Physiologically Based Kinetic Models of Parent Chemicals and Metabolites [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JLCM, Erickson J, Combs P, Ferguson S, Mansouri K, Kleinstreuer N. 2023. Integrating Enzyme Variability Into PB-K Models of Chemicals and Metabolites [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Hull V, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer N. 2023. Curating Chemical Use and Exposure Predictions to Contextualize Chemical Hazard [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Hull V, LaPratt T, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer NC. 2023. Curating Chemical Use Categories and Exposure Predictions to Inform Chemical Assessment [Abstract]. Presented at the 12th Annual Meeting: American Society for Cellular and Computational Toxicology, 23-25 October 2023.

Hull V, Reinke EN, Daniel AB, To KT, Karmaus AL, Allen DG, Mansouri K, Kleinstreuer NC. 2023. Compilation and Standardization of Rat Acute Inhalation Study Data to Support Predictive Modeling [Abstract]. Presented at the 12th Annual Meeting: American Society for Cellular and Computational Toxicology, 23-25 October 2023.

Karmaus AL. 2023. Leveraging In Vivo Variability to Assess Performance of Predictive Models and the Role of Reanalysis to Build Confidence via Consensus [Abstract]. Presented at the Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Karmaus AL, Borrel A, Feshuk M, Harrill A, Wittwehr C, Kleinstreuer NC. 2023. Annotations for ToxCast and Tox21 High-Throughput Screening Assays: Facilitating Assay Interpretation and Data Use [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Karmaus AL, Borrel A, Unnikrishnan A, Wittwehr C, Kleinstreuer NC. 2023. Annotating High-Throughput Screening Assays: Facilitating Interpretation and Data Use [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Karmaus AL, Ceger P, Rooney J, Bell S, Allen D, Kleinstreuer N. 2022. Developing In Vitro Assay Annotations to Provide Context and Facilitate Interpretation Toward Toxicological Endpoints [Abstract]. Presented at FutureTox V; 10-11 May 2022.

Karmaus AL, Daniel A, Hull V, Reinke E, Medvedev A, Allen D, Kleinstreuer NC, Casey W. 2022. Investigating the Impact of Cytochrome P450 Metabolism on Chemical-mediated Transcription Factor Transactivation [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Karmaus AL, Medvedev A, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer N, Casey W. 2023. Insights from Profiling Transcription Factor Transactivation with CYP450 Metabolism Integration [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Karmaus A, Rooney J, Ceger P, Abedini J, Phillips J, Bell S, Allen DG, Kleinstreuer NC. 2022. Providing Context to In Vitro High-Throughput Screening Data via Annotation and Visualization Tools [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Kleinstreuer N. 2023. Computational Crowdsourcing to Understand and Address Regulatory Needs: Case Studies for Prioritization of Environmental Chemicals Using AI/ML Approach [Abstract 1016]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Kleinstreuer N. 2023. Human Biological Relevance: Topical Toxicity Case Studies [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Kleinstreuer NC. 2023. Establishing Confidence in NAMs for Developmental and Reproductive Toxicology [Abstract]. Presented at the 63rd Annual Meeting of the Society for Birth Defects Research and Prevention; 24-28 June 2023.

Kleinstreuer NC. 2023. AI-Assisted Insights into Developmental Disruption [Abstract]. Presented at the 63rd Annual Meeting of the Society for Birth Defects Research and Prevention; 24-28 June 2023.

Kleinstreuer NC. 2023. The Central Role of Computational Toxicology in Toxicology 2.0 [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Krishna S, Berridge B, Kleinstreuer NC. 2022. High-Throughput Screening to Identify Chemical Cardiotoxic Potential [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Krishna S, Chang X, Eccles KM, Messier K, Kleinstreuer NC. 2023. Risk-Based, Geospatially Informed Prioritization of Potentially Cardiotoxic Chemicals [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Krishna S, Chang X, Kleinstreuer N. 2022. Applying IVIVE to Determine Margins of Exposure for Potentially Cardiotoxic Chemicals [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Lee S, Borrel A, To KT, Li T, Liu Z, Tong W, Benfenati E, Roncaglioni A, Manganaro A, Mansouri K, Kleinstreuer NC. 2023. Applying In Silico Toxicity Models Across the Tox21 Chemical Universe [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023; and the Annual Meeting of the Society of Toxicology, 19-23 March 2023.

Lee S, Li T, Liu Z, Tong W, Mansouri K, Kleinstreuer N. 2022. Applying Deep Learning Toxicity Models Across the Chemical Universe [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Mansouri K. 2023. Applications of Class-Based Approaches in Risk Assessment and Toxicological Research [Abstract 1053]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Mansouri K, Choksi N, Chang X, Allen D, Kleinstreuer N. 2022. OPERA Models for ADME Properties [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Mansouri K, Martin T, Chang X, Allen D, Williams A, Kleinstreuer N. 2022. OPERA Models to Support Regulatory Needs [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Mansouri K, Martin T, Chang X, Williams A, Kleinstreuer N. 2023. OPERA Models Supporting Regulatory Needs [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Maxwell G, Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke EN, Germolec D, Truax J, Allen DG, Kleinstreuer N. 2023. The SARA-ICE Model for Predicting Skin Sensitizer Potency [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Medvedev A, Karmaus AL, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer NC, Casey W. 2023. Mechanistic Insights from Profiling Chemical-Mediated Transcription Factor Transactivation with the Integration of Cytochrome P450 Metabolism [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Moreira-Filho J, Conway M, Schmitt C, Kleinstreuer N, Mansouri K. 2023. Interpretable Chemical Grouping Using an Automated KNIME Workflow [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Moreira-Filho JT, Conway M, Schmitt C, Kleinstreuer N, Mansouri K. 2022. Chemical Grouping Using an Automated KNIME Workflow: An Interpretable Machine Learning Approach [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Mumtaz M, Chang X, Allen DG, Kleinstreuer N. 2022. Application of In Vitro to In Vivo Extrapolation (IVIVE) to Informing In Vivo Point of Departure [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Oyetade OB, Karmaus AL, Reinke E, Allen DG, Kleinstreuer N. 2023. Variability of In Vivo Toxicology Studies: Impact on NAMs [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Ramaiahgari S, Krishna S, Kleinstreuer N, Liu J, Auerbach SS, Beverly B, Merrick BA, Berridge BR. 2023. In Vitro Assessment of Environmental Chemical Hazards on Cardiovascular Diseases [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Ramaiahgari S, Krishna S, Parham F, Auerbach S, Kleinstreuer N, Beverley B, Merrick A, Berridge B. 2022. A Comprehensive In Vitro Approach to Assess Environmental Chemical Hazard on Cardiovascular Diseases [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Reinke EN, Corsini E, Ono A, Fukuyama T, Ashikaga T, Gerberick GF. 2023. Peer Review Report of the EpiSensA Skin Sensitization Assay [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Reinke EN, Daniel AB, Hull VH, To KT, Karmaus AL, Allen DG, Mansouri K, Kleinstreuer NC. 2023. Development and Curation of an Acute Inhalation Toxicity Database [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Reinke EN, Strickland J, Truax J, To KT, Gulledge T, Johnson VJ, Larne O, Johansson H, Forreryd A, Allen DG, Kleinstreuer NC, Germolec D. 2023. Evaluating Skin Sensitization Hazard of Diverse Chemicals Using GARDskin [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Reynolds G, Reynolds J, Gilmour N, Strickland J, Germolec D, Truax J, Maxwell G, Kleinstreuer N. 2022. Modification of the Skin Allergy Risk Assessment (SARA) Model for GHS Classification and Its Application to Isothiazolinone Case Studies [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke E, Germolec D, Truax J, Allen D, Maxwell G, Kleinstreuer N. 2023. The Skin Allergy Risk Assessment-Integrated Chemical Environment (SARA-ICE) Model for UN GHS Classification: An Evaluation and Application in Case Studies [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Rogers B, Brown J, Allen D, Casey W, Clippinger A. 2022. Progress Towards the Replacement of In Vivo Leptospirosis Vaccine Potency Testing in the United States [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Rooney AA, Mansouri K, Bevington C, Hatlelid K, Helmick K, Blain R, Hannani A, Tracy W, Peppriell A, Cooney G, Sibrizzi C, Taylor K, Shipkowski K, Walker V. 2023. An Informatics Approach to Inform a Class-Based Analysis of Health Effects Associated with Exposure to Organohalogen Flame Retardants [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Choksi N, Daniel A, Hines D, Karmaus AL, McAfee E, Phillips J, Allen DG, Casey W, Kleinstreuer NC. 2022. Building Confidence in Alternative Methods through ICE [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Ross A, Sedykh A, Gombar V, Kleinstreuer N, Merrick A, Shah R, Casey W. 2022. OrbiTox: A Computational Translational Discovery Platform for Data Mining and Read-Across [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Sakamuru S, Ma D, Pierro JD, Baker NC, Kleinstreuer N, Cali JJ, Knudsen TB, Xia M. 2023. Development and Validation of Enzyme-Based CYP26A1 Inhibition Assay in a High-Throughput Screening Platform [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Salminen AT, Davis KJ, Felton RP, Nischal N, VonTungeln LS, Beland FA, Derr K, Brown PC, Ferrer M, Katz LM, Kleinstreuer NC, Leshin J, Manga P, Sadrieh N, Xia M, Fitzpatrick SC, Camacho L. 2023. Parallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In Vitro [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Strickland J, Abedini J, Allen D, Api AM, Germolec D, Gordon J, Hull V, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, To K, Truax J, Vanselow JT, Herzler M. 2022. Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency and Support Weight-of-Evidence Assessments [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Strickland J, To K, Matheson J, Germolec D, Allen DG, Api AM, Gordon J, Ko H, Thierse H, Truax J, Kleinstreuer NC, Herzler M. 2022. Variability of Human Reference Data for Skin Sensitization [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Strickland J, Truax J, Corvaro M, Settivari R, Henriquez J, Germolec D, Gehen S, Allen D, Kleinstreuer N. 2022. Application of Defined Approaches for Skin Sensitization to Agrochemical Products [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 27-31 March 2022.

Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec D. 2023. Application of Defined Approaches for Skin Sensitization for Chemicals of Federal Agency Interest [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec D. 2023. Defined Approaches for Skin Sensitization for Diverse Chemical Sets [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

To K, Karmaus A, Hull V, Allen D, Kleinstreuer N. 2022. Characterizing the Impacts of Assay Design on Cytotoxic Concentration Range [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

To KT, Oyetade O, Allen DG, Harrill A, Kleinstreuer N, Hogberg HT. 2023. Using NAMs to Address Variability and Susceptibility Across Populations [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer N. 2023. Web Application to Predict Skin Sensitization Using Defined Approaches [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023; and the 12th Annual Meeting: American Society for Cellular and Computational Toxicology, 23-25 October 2023.

To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer NC. 2023. DASS App: A Web Application for Applying Defined Approach [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Unnikrishnan A, Chang X, To K, Abedini J, Cook B, Hines D, McAfee E, Phillips J, Allen D, Kleinstreuer N. 2022. ICE Tools to Facilitate PBPK Modeling and IVIVE for Various Exposure Scenarios [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Unnikrishnan A, Chang X, Hull V, Tedla GE, Hogberg H, Sluka J, Wambaugh J, Allen D, Kleinstreuer N. 2023. Expanding PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues [Abstract]. Presented at the 12th Annual Meeting: American Society for Cellular and Computational Toxicology, 23-25 October 2023; and the 12th World Congress on Alternatives and Animal Use in the Life Sciences, 27-31 August 2023.

Unnikrishnan A, Hull V, Chang X, Borrel A, To K, Karmaus A, Phillips J, McAfee E, Allen D, Kleinstreuer N. 2023. Facilitating NAM-Based Chemical Assessments with the Integrated Chemical Environment [Abstract]. Presented at the 12th Annual Meeting: American Society for Cellular and Computational Toxicology; 23-25 October 2023.

Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel A, Cooper S, Phillips J, McAfee E, Allen DG, Casey W, Kleinstreuer N. 2023. Integrated Chemical Environment: An Advanced Platform Aiding NAM-based Chemical Assessments [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel A, Cooper S, Phillips J, McAfee E, Allen DG, Kleinstreuer NC. 2023. ICE Data and Tools to Advance NAMs [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

van der Zalm AJ, Barroso J, Browne P, Casey W, Henry T, Kleinstreuer NC, Lowit A, Perron M, Clippinger AJ. 2022. A Modern Framework to Establish Scientific Confidence in NAMs [Abstract]. Presented at the 11th Annual Meeting: American Society for Cellular and Computational Toxicology, 19-21 October 2022.

Wittwehr C, Chang X, Bisson W, Culbreth M, Edwards SW, Ferguson S, Harrill A, Hogberg H, Karmaus AL, Leite SB, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O'Brien JM, Reinke E, Schmitt C, Tucker NN, Virvilis V. 2023. Methods2AOP: An International Collaboration Advancing AOP Key Event Descriptions [Abstract]. Presented at the 12th World Congress on Alternatives and Animal Use in the Life Sciences; 27-31 August 2023.

Wittwehr C, Chang X, Bisson W, Edwards SW, Ferguson S, Harrill A, Hogberg H, Karmaus AL, Leite SB, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O’Brien JM, Reinke E, Schmitt C, Tucker NN, Virvilis V. 2023. Methods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event Descriptions [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 19-23 March 2023.

Sprankle C. January 2022. Impact of variability in animal test data discussed by Kleinstreuer. Environmental Factor [Internet]. [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2022/1/science-highlights/animal-test-data.

Sprankle C. March 2022. Hogberg brings developmental neurotoxicity expertise to NICEATM. Environmental Factor [Internet] [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2022/3/science-highlights/developmental-neurotoxicity.

Sprankle C. July 2022. Advances in nonanimal methods showcased at public forum. Environmental Factor [Internet]. [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2022/7/science-highlights/nonanimal-methods.

Sprankle C. September 2022. Making connections to reduce animal use in chemical safety testing. Environmental Factor [Internet]. [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2022/9/science-highlights/clemens-wittwehr.

Sprankle C. October 2022. Big questions on reducing animal testing tackled by panel. Environmental Factor [Internet]. [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2022/10/science-highlights/new-approach-methodologies.

Sprankle C. December 2022. Nonanimal testing experts connect with environmental justice community. Environmental Factor [Internet] [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2022/12/science-highlights/new-approach-methodologies.

Sprankle C. March 2023. New technologies to predict human toxicity explored in webinar. Environmental Factor [Internet] [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2023/3/science-highlights/toxicity-models.

Sprankle C. June 2023. Event highlights new technologies to replace animal testing. Environmental Factor [Internet] [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2023/6/science-highlights/new-approach-methodologies.

Sprankle C. July 2023. Workshop highlights promise and priorities for advancing organ models. Environmental Factor. [Internet] [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2023/7/science-highlights/tissue-chips.

Sprankle C. October 2023. Human chemical safety data available for new testing methods. Environmental Factor. [Internet] [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2023/10/science-highlights/chemical-safety-testing-database.

Sprankle C. November 2023. Future challenges in reducing animal testing assessed by panel. Environmental Factor. [Internet] [cited 28 Dec 2023]. Available from: https://factor.niehs.nih.gov/2023/11/science-highlights/experts-advise-on-using-nonanimal-chemical-safety-testing.