On June 15, 2026, the National Institutes of Health (NIH) announced that moving forward, NICEATM will continue its important work as a division of the newly created NIH Office of Research Innovation, Validation, and Application (ORIVA). Soon, NICEATM content that you see on this webpage will be transitioned to the NIH ORIVA webpage. In the meantime, you can learn more about the new office and how it is structured.

https://ntp.niehs.nih.gov/go/804412

NICEATM Abstracts Published Since 2023

For each abstract, table lists presentation date, authors, title (link to abstract PDF), and presentation venue (link to meeting page on NICEATM site)
Year PresentedAuthorsTitlePresentation Venue
2025Kreutz A, Reisfeld B, Chang X, Hamm J, Ryan K, Hogberg H, Hsieh JHImplementation of human and zebrafish physiologically based pharmacokinetic modeling for developmental neurotoxicity hazard assessment19th Biannual Meeting of the International Neurotoxicity Association
2025Hull V, Hill B, Unnikrishnan A, Reinke E, Kleinstreuer N, Hogberg HEnhancing a curated high-throughput screening pipeline to improve toxicological interpretations of in vitro data13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Rangananth D, Moreira-Filho JT, Mansouri K, Kleinstreuer NAutomating the generation of QSAR prediction reporting format reports using OPERA Models and KNIME13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Hull V, LaPratt T, Reinke E, Kleinstreuer NIntegrating structure-based chemical taxonomies to focus queries of NAMs data13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Reinke E, Reynolds E, Reynolds J, Gilmour N, Marco B, Maxwell G, Kleinstreuer NSARA-ICE: a self-contained model for predicting a human relevant point-of-departure for skin sensitization13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Unnikrishnan A, Chang X, Kreutz A, LaPratt T, Hogberg H, Sluka JP, Wambaugh J, Li D, Linakis M, Reinke E, Kleinstreuer NPhysiologically based pharmacokinetic (PBPK) modeling approach to quantify chemical distribution in brain and adipose compartments13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Unnikrishnan A, To K, Herzler M, Germolec D, Reinke E, Kleinstreuer NWeb application to classify and subcategorize skin sensitizers using human data13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Hill B, Hamm J, Hsieh JH, Knapp B, Reinke E, Hogberg H, Ryan KUnderstanding the range of phenotypic responses for the embryonic zebrafish developmental toxicity assay13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Casey WLeveraging strategic funding and public-private partnerships to establish confidence in NAMs for biomedical research and regulatory testing13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Reinke EEnsuring transparency and rigor in the peer review of new approach methods for skin sensitization assessment13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Casey WTranslating experience into progress: advancing regulatory acceptance of NGRA13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Mansouri K, Moreira-Filho JT, Kleinstreuer NUnderstanding the concept of similarity and its applications to toxicological research and risk assessment13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Daniel A, Casey W, Chen T, Crizer D, Ferguson S, Gordon J, Hamm J, Magurany K, Morefield S, Reinke E, Sprankle C, Fitzpatrick S, Kleinstreuer NValidation powerlifting: strengthening confidence in NAMs with flexibility and fitness (for purpose)13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Scheufen Tieghi R, Beasley JM, Moreira-Filho JT, Hogberg HT, Tropsha A, Kleinstreuer N, Muratov EElucidation of adverse outcome pathways for compound-induced developmental neurotoxicity using knowledge graphs13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Reinke EIntegrating NAMs for quantitative skin sensitization potency assessment into regulatory frameworks: experience from the work in OECD TG 49713th World Congress on Alternatives and Animal Use in the Life Sciences
2025Mansouri K, Kleinstreuer NAssessing the utility of the Collaborative Acute Toxicity Modeling Suite (CATMoS) from ecological risk assessment to human health hazard13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Hogberg H, Mangas I, Sachana MAdvancing defined approaches for developmental neurotoxicity using the integrated testing and assessment framework template13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Mansouri K, Kleinstreuer NThe CATMoS model: an in silico tool for predicting acute oral toxicity13th World Congress on Alternatives and Animal Use in the Life Sciences
2025Chen Y, Salazar K, Mansouri K, Kleinstreuer NA machine learning approach for predicting inhalation acute toxicity (LC50) values of chemicals using a two-stage regression modelSociety of Toxicology
2025Krishna S, Chang X, Eccles K, Messier K, Kleinstreuer NMultiscale risk characterization of chemical cardiotoxicity: integrated in vitro and in silico multiscale modeling reveals cardiovascular risk from chemical exposuresSociety of Toxicology
2025Tropsha A, Muratov E, Kleinstreuer NSystemic and topical toxicity (STOPTOX) predictor: model development and external validationSociety of Toxicology
2025Kleinstreuer NAdvancing one health preparedness: integrating computational dynamic and kinetic systems models into regulatory frameworksSociety of Toxicology
2025Yang S, Knudsen T, Carstens K, Hogberg HT, Xia MDevelopment of a high-throughput assay platform for neuroinflammation detection using iPSC-derived microgliaSociety of Toxicology
2025Kleinstreuer NBuilding and applying high-confidence computational models in med techSociety of Toxicology
2025Haber L, Bradley MA, Martin EM, Snow SJ, Robertson JM, Fies W, Borrel A, Reinke E, Bevington C, Gordon J, Cho T, Hooker E, Hatlelid KClass-based hazard and dose-response assessment of polyhalogenated organophosphate flame retardantsSociety of Toxicology
2025Scheufen Tieghi R, Moreira-Filho J, Martin H, Wellnitz J, Otoch MC, Rath M, Tropsha A, Muratov E, Kleinstreuer NUsing ML for human skin sensitization prediction - a novel in silico tool using HPPT dataSociety of Toxicology
2025Moreira-Filho J, Ranganath D, Tieghi R, Patton R, Sutherland V, Schmitt C, Rooney A, Walker V, Fostel J, Saddler T, Reif D, Mansouri K, Kleinstreuer NAutomating data extraction from scientific literature and general PDF files using large language models and KNIME: An application in toxicologySociety of Toxicology
2025Hogberg HIntegrated approaches to testing and assessment case study of mifepristone to determine developmental neurotoxic potentialSociety of Toxicology
2025Ehrlich D, Krishna S, Kleinstreuer NData-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosisSociety of Toxicology
2025Modaresi S, Salminen AT, Davis KJ, Felton RP, Sun J, Beland FA, Derr K, Brown PC, Ferrer M, Katz LM, Kleinstreuer NC, Leshin J, Manga P, Sadrieh N, Xia M, Fitzpatrick SC, Camacho LEvaluation and comparison of in vitro permeation testing (IVPT) and barrier function in alternative skin models and excised human skinSociety of Toxicology
2025Kruetz AIn vitro to in vivo extrapolation application for assessing developmental neurotoxicitySociety of Toxicology
2025Scheufen Tieghi RDeTox: An in silico alternative to animal testing for predicting developmental toxicity potentialSociety of Toxicology
2025Sakamuru S, Sukhawanit R, Wood S, Huang R, Klumpp-Thomas C, Simeonov A, Kleinstreuer N, Knudsen TB, Xia MInhibitors of Cytochrome P450 26A1 identified from screening the Tox21 10K compound librarySociety of Toxicology
2025Ranganath D, Moreira-Filho JT, Collins BJ, Waidyanatha S, Casey W, Kleinstreuer N, Mansouri KDemocratizing cheminformatics: case studies using the MoVIZ pipeline for automated chemical grouping and toxicological insightsSociety of Toxicology
2025Unnikrishnan A, To KT, Herzler M, Germolec D, Reinke E, Kleinstreuer NWeb Application to Classify and Subcategorize Skin Sensitizers Using Human DataSociety of Toxicology
2025Kreutz A, Karmaus AL, Oyetade OB, Paul Friedman K, Allen DG, Reinke EN, Paparella M, Kleinstreuer NCQuantifying the Reproducibility and Variability of In Vivo Guideline Toxicology StudiesSociety of Toxicology
2025Hill B, Hamm J, Hsieh JH, Reinke EN, Hogberg HT, Ryan KUnderstanding the Range of Phenotypic Responses for the Embryonic Zebrafish Developmental Toxicity AssaySociety of Toxicology
2025Cuomo D, Karmaus A, Hill B, Feshuk M, Osborne G, Blake B, Druwe I, Wang A, Rigutto G, McHale C, Smith MT, Facchin C, De Conti A, Madia F, Kleinstreuer N, Chiu WA, Borrel AMapping ToxCast/Tox21 High-throughput Screening Assay Endpoints to Key Characteristics of CarcinogensSociety of Toxicology
2024Daniel A, van der Zalm A, Raabe H, Clippinger A, Reinke E, Allen D, Kleinstreuer NDefined Approaches for Predicting GHS and EPA Eye Irritation Classification of AgrochemicalsAmerican Society for Cellular and Computational Toxicology
2024Reinke E, Ulrey A, Hoffman S, Basketter D, Corsini E, Ashikaga T, Gerberick GFPeer Review for Validation Studies - Building Confidence and Transparency into a New Validation ParadigmAmerican Society for Cellular and Computational Toxicology
2024Borrel A, Cuomo D, Hill B, Reisfeld B, Karmaus A, Osborne G, Feshuk M, Blake B, Druwe I, Wang A, Bisson W, Madia F, Facchin C, De Conti A, Rigutto G, McHale C, Smith M, Chiu WA, Kleinstreuer NMapping Tox21/ToxCast HTS Data to Key Characteristics of CarcinogensAmerican Society for Cellular and Computational Toxicology
2024Fies W, Luh J, Snow S, Martin E, Haber L, Bradley M, Reinke E, Borrel A, Hooker E, Bevington C, Gordon J, Cho TClass-based Hazard, Exposure, and Dose-response Assessment of Polyhalogenated Organophosphate Flame RetardantsAmerican Society for Cellular and Computational Toxicology
2024Oyetade O, Kreutz A, Chang X, Hsieh JH, Behl M, Reinke E, Hogberg HIntegrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame RetardantsAmerican Society for Cellular and Computational Toxicology
2024To KT, Borrel A, Reinke E, Kleinstreuer NDASS App v2.0: Implementing OECD Guideline No. 497 UpdatesAmerican Society for Cellular and Computational Toxicology
2024Reinke E, Gilmour N, Reynolds G, Reynolds J, Marco B, Borrel A, Maxwell G, Kleinstreuer NSARA-ICE: A Self-contained Model for Predicting a Human-relevant Point-of-departure for Skin SensitizationAmerican Society for Cellular and Computational Toxicology
2024Scheufen Tieghi R, Moreira-Filho JT, Martin HJ, Wellnitz J, Otoch C, Rath M, Tropsha A, Muratov EN, Kleinstreuer NHuSSPred: an in-silico HPPT-based tool for Human Skin Sensitization PredictionAmerican Society for Cellular and Computational Toxicology
2024Scheufen Tieghi R, Moreira-Filho JT, Rath M, Wellnitz J, Martin HJ, Gates K, Hogberg-Durdock HT, Kleinstreuer N, Tropsha A, Muratov ENDeTox: An In Silico Alternative to Animal Testing for Predicting Developmental Toxicity PotentialAmerican Society for Cellular and Computational Toxicology
2024LaPratt T, Hull V, Reinke E, Kleinstreuer NStructure-based Chemical Taxonomy to Focus Chemical QueriesAmerican Society for Cellular and Computational Toxicology
2024Reisfeld B, Borrel A, Chang X, Daniel A, Hill B, Hull V, To KT, Unnikrishnan A, Green A, McAfee E, Phillips J, Reinke E, Mansouri K, Kleinstreuer NThe Integrated Chemical Environment (ICE): Advancing Data Availability and Computational Tool Accessibility for the Development, Evaluation, and Application of New Approach MethodsAmerican Society for Cellular and Computational Toxicology
2024Unnikrishnan A, To KT, Borrel A, Hull V, Daniel A, Reinke E, Kleinstreuer NHarmonizing Tox Data to Enhance Confidence and UtilityAmerican Society for Cellular and Computational Toxicology
2024Hill B, Auman JT, Unnikrishnan A, Karmaus A, Hogberg H, Reinke E, Kleinstreuer NIncorporating Ontologies into High-Throughput Screening Assay Annotations to Facilitate Interpretation and Increase Data UseAmerican Society for Cellular and Computational Toxicology
2024Germolec DGARDAir Testing of Federal Agency Partners Chemicals of ConcernAmerican Society for Cellular and Computational Toxicology
2024Kleinstreuer NCardiotoxicity NAMs Across the Translational Toxicology PipelineAmerican Society for Cellular and Computational Toxicology
2024Chang XIn Vitro to In Vivo Extrapolation Application to Promote the Use of NAMs for Assessing Inhalation ToxicitySociety of Toxicology
2024Lane TR, Snyder S, Harris JS, Hamm J, Urbina F, Unnikrishnan A, Borrel A, Karmaus A , Behl M, Hogberg-Durdock HSeizure Predictions Using Adverse Outcome Pathway-Based Fast Interpretable Greedy-Tree Sums ModelingSociety of Toxicology
2024Krishna S, Beverly B, Walker VR, Kleinstreuer NC, Hannani A, Whately H, Trgovcich J, Rochester J, Sprowles J, Miller M, Tracy W, Sibrizzi C, Rooney AAArtificial Intelligence Approaches to Identify and Categorize Health-Relevant Research for Big Questions: Case Study of Cardiovascular Disease and Environmental ExposuresSociety of Toxicology
2024Whitehead TM, Strickland J, Conduit GJ, Borrel A, Mucs D, Baskerville-Abraham IToxicological Data Gap Filling of Ingredients; Comparison of Machine Learning Based Imputation and Traditional QSAR MethodsSociety of Toxicology
2024Moreira-Filho J, Ranganath D, Conway M, Waidyanatha S, Collins B, Schmitt C, Kleinstreuer N, Mansouri KModeling and Visualization (MoVIZ): Democratizing Cheminformatics with a User-friendly Guided PipelineSociety of Toxicology
2024Hsieh J, Wang Z, Nolte S, Marvel S, Hill B, Hamm J, Roberts G, Schmitt, Ryan KSEAZIT-DIVER: A Web Application for Integrating and Visualizing Inter-laboratory Data on Substance-Induced Developmental Toxicity Phenotypes in Zebrafish EmbryosSociety of Toxicology
2024McPherson CA, Combs P, Cushman J, Erickson J, Hsieh J, Hall L, Hogberg HT, Kendricks K, Sills RIntegrating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery to Identify Compounds for Future StudySociety of Toxicology
2024Sutherland V, Hogberg HT, Behl M, Hsieh J, Mansouri K, Mehta S, Roberts G, Ryan K, Taylor KW, Walker N, Walker VR, Witchey S, Rooney AAOrganophosphate Flame Retardants: A Comprehensive Toxicological AssessmentSociety of Toxicology
2024Scheufen Tieghi R, Rath MK, Moreira-Filho JT, Martin H, Beasley J, Hogberg HT, Kleinstreuer N, Muratov EPregPred: A Model to Predict the Developmental Toxicity Potential of Environmental Chemicals and FDA-Approved Drugs and CosmeticsSociety of Toxicology
2024Borrel ADeep-Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis MechanismsSociety of Toxicology
2024de Aguiar Marciano L, Filipe Costa L, Silva Cardoso N, de Araújo Paula F, Pupin Silvério A, Kleinstreuer N, Martins IRisk Assessment of Exposure to Triazole Fungicides by Human Biomonitoring and Mechanistic DataSociety of Toxicology
2024Hogberg-Durdock H, Hamm J, Borrel A, Karmaus A , Lane T, Unnikrishnan A, Urbina F, Behl MIdentifying Seizure-Inducing Biological Targets: A Collaborative Approach Using AOP Networks, In Vitro Assays, and Computational ToolsSociety of Toxicology
2024Unnikrishnan A, Chang X, Kreutz A, Hull V, Tedla GE, Hogberg HT, Sluka JP, Wambaugh JF, Allen DG, Kleinstreuer NPBPK Modeling to Predict Chemical Distribution in Brain and Adipose TissuesSociety of Toxicology
2024Tedla G, Borrel A, Karmaus A, Hull V, To KT, Auman JT, Allen DG, Kleinstreuer NMachine learning-based development of cytotoxicity flags within the Tox21/ToxCast assaysSociety of Toxicology
2024Sullivan K, Reinke E, Macmillan DS, Raabe H, Germolec D, Allen D, Choi E, Filipovska J, Kleinstreuer NAdvancing Flexibility for Defined Approach Guidelines: Developing Performance Standards to Incorporate Alternate Information Sources into the Defined Approach for Skin Sensitization GuidelineSociety of Toxicology
2024Reinke EN, LaPratt T, Strickland JA, Germolec D, Truax J, Reynolds J, Reynolds G, Gilmour N, Allen DG, Maxwell G, Kleinstreuer NCApplication of the SARA-ICE Skin Sensitization Defined Approach to a Diverse Chemical Set – a Comparative Case StudySociety of Toxicology
2024Oyetade OB, Chang X, Kreutz A, Hsieh JH, Behl M, Sipes N, Allen DG, Hogberg HTOPFR Prioritization using the Developmental Neurotoxicity In Vitro Test Battery: An Update to OECD IATA Case StudySociety of Toxicology
2024Maxwell G, Reynolds J, Gilmour N, Strickland J, Reinke EN, Germolec D, Truax J, Allen DG, Blaylock M, LaPratt T, Reynolds G, Kleinstreuer NApplication of Skin Allergy Risk Assessment-Integrated Chemical Environment Defined Approach (SARA-ICE DA) to Assess Skin Sensitization Potency of Isothiazolinone CompoundsSociety of Toxicology
2024Kreutz A, Chang X, Lawless M, Shafer TJ, Wambaugh JF, Wetmore BA, Allen DG, Hogberg HTIn Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic ModelsSociety of Toxicology
2024Johnson VJ, Reinke EN, LaPratt TR, Strickland J, To KT, Larne O, Johansson H, Forreryd A, Allen DG, Kleinstreuer NC, Germolec DRTesting of Regulatory-Relevant Chemicals for Skin and Respiratory Sensitization HazardSociety of Toxicology
2024Hull V, LaPratt TR, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer NCCurating chemical use categories and exposure predictions to inform chemical assessmentSociety of Toxicology
2024Hill BN, Reinke EN, Auman JT, Unnikrishnan A, Allen DG, Kleinstreuer NCIncorporating Ontologies into High Throughput Screening Assay Annotations to Increase Data Use and InterpretationSociety of Toxicology
2024Daniel AB, van der Zalm AJ, Raabe HA, Clippinger AJ, Kleinstreuer NC, Allen DGPredicting GHS Hazard Classification for Eye Irritation/Corrosion Potential of Agrochemical Formulations Using Defined ApproachesSociety of Toxicology
2024Chang X, Palmer J, Donley E, Reinke E, Allen D, Kleinstreuer NIVIVE to Facilitate Animal-free Risk Assessment of Potential Developmental ToxicantsSociety of Toxicology
2024Borrel A, Tedla G, To KT, Hill B, Karmaus AL, Wang A, Luechtefeld T, Reif D, Allen DG, Kleinstreuer NCModern In Vitro Imputation Modeling and Machine Learning to Predict Chemical CarcinogenicitySociety of Toxicology
2024Allen DG, Hull V, Reinke EN, Daniel AB, To KT, Karmaus AL, Mansouri K, Kleinstreuer NCCuration and Characterization of a Reference Rat Acute Inhalation Toxicity DatabaseSociety of Toxicology
2024Marko S, Allen DG, Hogberg H, Oyetade OB, Kleinstreuer NC, Carder JOpportunities for Encouraging the Consideration of Alternative MethodsSociety of Toxicology
2023Borrel A, Unnikrishnan A, Allen D, Kleinstreuer NChemMaps.com v2.0 - Exploring the Environmental Chemical UniverseSoutheast Regional Meeting of the American Chemical Society
2023Borrel A, Unnikrishnan A, Allen D, Kleinstreuer NChemMaps.com v2.0 - Exploring the Environmental Chemical UniverseAmerican Society for Cellular and Computational Toxicology
2023Borrel A, Karmaus AL, Tedla G, Mansouri K, Luechtefeld T, Lunn R, Wang A, Allen D, Kleinstreuer NDeep Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms American Society for Cellular and Computational Toxicology
2023Hull V, Reinke EN, Daniel AB, To KT, Karmaus AL, Allen DG, Mansouri K, Kleinstreuer NCCompilation and Standardization of Rat Acute Inhalation Study Data to Support Predictive ModelingAmerican Society for Cellular and Computational Toxicology
2023Hull V, LaPratt T, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer NCCurating Chemical Use Categories and Exposure Predictions to Inform Chemical AssessmentAmerican Society for Cellular and Computational Toxicology
2023To KT, Strickland J, Reinke E, Borrel A, Truax J, Allen D, Kleinstreuer NWeb Application to Predict Skin Sensitization Using Defined Approaches American Society for Cellular and Computational Toxicology
2023Herzler M, To KT, Unnikrishnan A, Abedini J, Allen D, Germolec D, Gordon J, Kleinstreuer K, Ko HS, Matheson J, Thierse HJ, Truax J, Vanselow JT, Strickland JEvaluation of Skin Sensitization Classification Rules to Reflect Induction Potency in HumansAmerican Society for Cellular and Computational Toxicology
2023Unnikrishnan A, Chang X, Hull V, Tedla GE, Hogberg H, Sluka J, Wambaugh J, Allen D, Kleinstreuer NExpanding PBPK Modeling to Predict Chemical Distribution in Brain and Adipose TissuesAmerican Society for Cellular and Computational Toxicology
2023Unnikrishnan A, Hull V, Chang X, Borrel A, To K, Karmaus A, Phillips J, McAfee E, Allen D, Kleinstreuer NFacilitating NAM-Based Chemical Assessments with the Integrated Chemical EnvironmentAmerican Society for Cellular and Computational Toxicology
2023Hogberg H, Behl M, Combs P, Cushman J, Erickson J, Hall L, Hsieh JH, Kendricks D, Kreutz A, Stanko J, Thomas D, Wilson L, Zhang X, Sills R, McPherson CGenerating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Daniel A, van der Zalm A, Raabe H, Clippinger AJ, Kleinstreuer N, Allen DDefined Approaches for GHS Categorization to Assess Eye Irritation Potential of Agrochemical Formulations12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Wittwehr C, Chang X, Bisson W, Culbreth M, Edwards SW, Ferguson S, Harrill A, Hogberg H, Karmaus AL, Leite SB, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O'Brien JM, Reinke E, Schmitt C, Tucker NN, Virvilis VMethods2AOP: An International Collaboration Advancing AOP Key Event Descriptions12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Unnikrishnan A, Chang X, Karmaus AL, Hull V, Allen DG, Kleinstreuer NCExpanding PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel A, Cooper S, Phillips J, McAfee E, Allen DG, Kleinstreuer NCICE Data and Tools to Advance NAMs12th World Congress on Alternatives and Animal Use in the Life Sciences
2023To KT, Oyetade O, Allen DG, Harrill A, Kleinstreuer N, Hogberg HTUsing NAMs to Address Variability and Susceptibility Across Populations12th World Congress on Alternatives and Animal Use in the Life Sciences
2023To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer NWeb Application to Predict Skin Sensitization Using Defined Approaches12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec DDefined Approaches for Skin Sensitization for Diverse Chemical Sets12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Reinke EN, Daniel AB, Hull VH, To KT, Karmaus AL, Allen DG, Mansouri K, Kleinstreuer NCDevelopment and Curation of an Acute Inhalation Toxicity Database12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Reinke EN, Strickland J, Truax J, To KT, Gulledge T, Johnson VJ, Larne O, Johansson H, Forreryd A, Allen DG, Kleinstreuer NC, Germolec DEvaluating Skin Sensitization Hazard of Diverse Chemicals Using GARDskin 12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Oyetade OB, Karmaus AL, Reinke E, Allen DG, Kleinstreuer NVariability of In Vivo Toxicology Studies: Impact on NAMs12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Maxwell G, Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke EN, Germolec D, Truax J, Allen DG, Kleinstreuer NThe SARA-ICE Model for Predicting Skin Sensitizer Potency12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Lee S, Borrel A, To KT, Li T, Liu Z, Tong W, Benfenati E, Roncaglioni A, Manganaro A, Mansouri K, Kleinstreuer NCApplying In Silico Toxicity Models Across the Tox21 Chemical Universe12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Karmaus AL, Borrel A, Unnikrishnan A, Wittwehr C, Kleinstreuer NCAnnotating High-Throughput Screening Assays: Facilitating Interpretation and Data Use12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Karmaus AL, Medvedev A, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer N, Casey WInsights from Profiling Transcription Factor Transactivation with CYP450 Metabolism Integration12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JLCM, Erickson J, Combs P, Ferguson S, Mansouri K, Kleinstreuer NIntegrating Enzyme Variability Into PB-K Models of Chemicals and Metabolites12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Hull V, Karmaus AL, To KT, Unnikrishnan A, Allen DG, Kleinstreuer NCurating Chemical Use and Exposure Predictions to Contextualize Chemical Hazard12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Hull V, Borrel A, Karmaus AL, Allen DG, Kleinstreuer NIntegration of Technological Interference into Curated HTS Data12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer N, Ko H-S, Matheson J, Thierse H-J, Truax J, Vanselow JT, Strickland JEvaluation of Skin Sensitization Classification Rules to Reflect Human Potency12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Elliott J, Gutierrez R, Johnson VJ, Germolec D, Allen DG, Kleinstreuer NC, Strickland JValidation of the Electrophilic Allergen Screening Assay (EASA)12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Daniel A, Kleinstreuer N, Allen D, Blaylock M, Glover K, Goralski T, Kerr C, Tagle D, Williams M, Holmes AA Working Group Supporting Adoption of MPS in Infectious Disease Research12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Chang X, Reinke E, Daniel A, Allen DG, Kleinstreuer N, Mumtaz MMUsing In Vitro Data and PBPK Models to Predict Inhalation Toxicity12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Carder J, Allen DG, Hogberg H, Oyetade O, Kleinstreuer N, Marko SOpportunities for Encouraging the Consideration of Alternative Methods12th World Congress on Alternatives and Animal Use in the Life Sciencess
2023Borrel A, Karmaus AL, Tedla G, Mansouri K, Luechtefeld T, Lunn R, Wang A, Allen DG, Kleinstreuer NDeep Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Borrel A, Unnikrishnan A, Allen DG, Kleinstreuer NChemMaps.com V2 - Exploring the Environmental Chemical Universe12th World Congress on Alternatives and Animal Use in the Life Sciences
2023Kleinstreuer NCEstablishing Confidence in NAMs for Developmental and Reproductive ToxicologySociety for Birth Defects Research and Prevention
2023Kleinstreuer NCAI-Assisted Insights into Developmental DisruptionSociety for Birth Defects Research and Prevention
2023Beardslee RA, Salazar K, van der Zalm A, Camacho IA, Brunner R, Raabe H, Allen D, Daniel A, Kleinstreuer N, O’Dell L, Clippinger A, Scarano L, Lowit AEvaluating New Chemicals in the U.S. under the Toxic Substances Control Act (TSCA): Application of New Approach Methods (NAMs) to Evaluate Eye IrritationSociety of Toxicology
2023Borrel A, Unnikrishnan A, Fourches D, Allen DG, Kleinstreuer NChemMaps.com V2 – Exploring the Environmental Chemical UniverseSociety of Toxicology
2023Karmaus AL, Borrel A, Feshuk M, Harrill A, Wittwehr C, Kleinstreuer NCAnnotations for ToxCast and Tox21 High-Throughput Screening Assays: Facilitating Assay Interpretation and Data UseSociety of Toxicology
2023Wittwehr C, Chang X, Bisson W, Edwards SW, Ferguson S, Harrill A, Hogberg H, Karmaus AL, Leite SB, Lekka E, Kleinstreuer NC, Markey KJ, Masci AM, Mennecozzi M, Mortensen HM, O’Brien JM, Reinke E, Schmitt C, Tucker NN, Virvilis VMethods2AOP: An International Collaboration to Integrate Assay Annotations into the AOP Key Event DescriptionsSociety of Toxicology
2023Unnikrishnan A, Karmaus AL, Hull V, Chang X, Borrel A, To KT, Daniel A, Cooper S, Phillips J, McAfee E, Allen DG, Casey W, Kleinstreuer NIntegrated Chemical Environment: An Advanced Platform Aiding NAM-based Chemical AssessmentsSociety of Toxicology
2023To KT, Strickland J, Borrel A, Truax J, Allen DG, Kleinstreuer NCDASS App: A Web Application for Applying Defined Approaches for Skin Sensitization to Predict Hazard and Potency CategorizationSociety of Toxicology
2023Sakamuru S, Ma D, Pierro JD, Baker NC, Kleinstreuer N, Cali JJ, Knudsen TB, Xia MDevelopment and Validation of Enzyme-Based CYP26A1 Inhibition Assay in a High-Throughput Screening PlatformSociety of Toxicology
2023Ramaiahgari S, Krishna S, Kleinstreuer N, Liu J, Auerbach SS, Beverly B, Merrick BA, Berridge BRIn Vitro Assessment of Environmental Chemical Hazards on Cardiovascular DiseasesSociety of Toxicology
2023Rooney AA, Mansouri K, Bevington C, Hatlelid K, Helmick K, Blain R, Hannani A, Tracy W, Peppriell A, Cooney G, Sibrizzi C, Taylor K, Shipkowski K, Walker VAn Informatics Approach to Inform a Class-Based Analysis of Health Effects Associated with Exposure to Organohalogen Flame RetardantsSociety of Toxicology
2023Herzler M, Abedini J, To KT, Allen DG, Api AM, Germolec D, Gordon J, Kleinstreuer NC, Ko H, Matheson J, Thierse H, Truax J, Vanselow J, Strickland JEvaluation of Skin Sensitization Classification Rules to Reflect Human PotencySociety of Toxicology
2023Kleinstreuer NComputational Crowdsourcing to Understand and Address Regulatory Needs: Case Studies for Prioritization of Environmental Chemicals Using AI/ML ApproachSociety of Toxicology
2023Mansouri KApplications of Class-Based Approaches in Risk Assessment and Toxicological ResearchSociety of Toxicology
2023Daniel AB, van der Zalm AJ, Clippinger AJ, Kleinstreuer NC, Allen DGThree-Phase Testing of Agrochemical Formulations: Developing a Defined Approach for Eye Irritation PotentialSociety of Toxicology
2023Medvedev A, Karmaus AL, Hull V, Reinke EN, Daniel AB, Allen DG, Kleinstreuer NC, Casey WMechanistic Insights from Profiling Chemical-Mediated Transcription Factor Transactivation with the Integration of Cytochrome P450 MetabolismSociety of Toxicology
2023Kleinstreuer NHuman Biological Relevance: Topical Toxicity Case StudiesSociety of Toxicology
2023Mansouri K, Martin T, Chang X, Williams A, Kleinstreuer NOPERA Models Supporting Regulatory NeedsSociety of Toxicology
2023Moreira Filho J, Conway M, Schmitt C, Kleinstreuer N, Mansouri KInterpretable Chemical Grouping Using an Automated KNIME WorkflowSociety of Toxicology
2023Chang X, Reinke EN, Daniel AB, Allen DG, Mumtaz MM, Kleinstreuer NCCombining NAM Data and IVIVE for Evaluating Potential Inhalation ToxicitySociety of Toxicology
2023Hull V, Hines D, Unnikrishnan A, Karmaus AL, Allen DG, Dorne JC, Erickson J, Combs P, Ferguson S, Kleinstreuer NC, Mansouri KIntegrating Population Enzyme Variability into Physiologically Based Kinetic Models of Parent Chemicals and MetabolitesSociety of Toxicology
2023Karmaus ALLeveraging In Vivo Variability to Assess Performance of Predictive Models and the Role of Reanalysis to Build Confidence via ConsensusSociety of Toxicology
2023Gordon J, Truax J, Borrel A, Reinke EN, Adams V, Rua D, Petersen E, Uhl R, Allen DG, Kleinstreuer NC, Strickland JValidation of the Electrophilic Allergen Screening Assay (EASA) to Detect Substances That Impact the Initial Key Event in the Adverse Outcome Pathway for Skin SensitizationSociety of Toxicology
2023Strickland J, Truax J, To KT, Reinke EN, Gulledge T, Johnson VJ, Allen DG, Kleinstreuer NC, Germolec DApplication of Defined Approaches for Skin Sensitization for Chemicals of Federal Agency InterestSociety of Toxicology
2023Reinke EN, Corsini E, Ono A, Fukuyama T, Ashikaga T, Gerberick GFPeer Review Report of the EpiSensA Skin Sensitization AssaySociety of Toxicology
2023Lee S, Borrel A, To KT, Li T, Liu Z, Tong W, Benfenati E, Roncaglioni A, Manganaro A, Mansouri K, Kleinstreuer NCApplying In Silico Toxicity Models across the Tox21 Chemical UniverseSociety of Toxicology
2023Hogberg-Durdock H, Lam A, Elan O, Shahbaz MA, Clerbaux L, Bal-Price A, Coecke S, Concha R, De Bernardi F, Edrosa E, Hargreaves AJ, Kanninen KM, Munoz A, Pistollato F, Saravanan S, Garcia-Reyero N, Wittwehr C, Sachana MThe Adverse Outcome Pathway Framework Applied to Neurological Symptoms of COVID-19Society of Toxicology
2023Eccles KM, Karmaus AL, Kleinstreuer NC, Parham F, Wambaugh JF, Messier KPMapping a Path to Disease: Quantifying the Risk of Exposure to Environmental Chemical Mixtures via a Common Molecular Target Using a Geospatial Modeling ApproachSociety of Toxicology
2023Krishna S, Chang X, Eccles KM, Messier K, Kleinstreuer NCRisk-Based, Geospatially Informed Prioritization of Potentially Cardiotoxic ChemicalsSociety of Toxicology
2023Salminen AT, Davis KJ, Felton RP, Nischal N, VonTungeln LS, Beland FA, Derr K, Brown PC, Ferrer M, Katz LM, Kleinstreuer NC, Leshin J, Manga P, Sadrieh N, Xia M, Fitzpatrick SC, Camacho LParallel Evaluation of Alternative Skin Barrier Models and Excised Human Skin for Dermal Absorption Studies In VitroSociety of Toxicology
2023Reynolds G, Reynolds J, Gilmour N, Strickland J, Reinke E, Germolec D, Truax J, Allen D, Maxwell G, Kleinstreuer NThe Skin Allergy Risk Assessment-Integrated Chemical Environment (SARA-ICE) Model for UN GHS Classification: An Evaluation and Application in Case StudiesSociety of Toxicology
2023Kleinstreuer NCThe Central Role of Computational Toxicology in Toxicology 2.0Society of Toxicology