NICEATM and ICCVAM Agency Presentations at WC12
12th World Congress on Alternatives and Animal Use in the Life Sciences
August 27-31, 2023 – Niagara Falls, Canada
Oral Presentations
Regulatory Acceptance and Global Harmonization
Session S400: Adversity Reinvented: Non-Animal Frameworks for Predictive & Protective Decision-Making
Abstract 162: In the Room Where It Happens: Assessing Pesticide Hazard
Presenter: Alison Harrill, U.S. Environmental Protection Agency
Session S402: Unlocking a New NAM-Based Paradigm: Transforming the Evaluation of Agrochemicals
Abstract 93: Defined Approaches for GHS Categorization to Assess Eye Irritation Potential of Agrochemical Formulations
Presenter: Amber Daniel, Inotiv (contractor supporting NICEATM)
Session S403: Advancements and Opportunities in the Replacement, Reduction and Refinement of Acute Toxicity Tests
Abstract 91: Development and Curation of an Acute Inhalation Toxicity Database
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)
Abstract 467: Replacing Animal Use in the Acute Toxicity "Six-Pack" for Industrial Chemicals and Pesticides: US Perspective
Presenter: Lindsay O'Dell, U.S. Environmental Protection Agency
Session S404: Is it Good Enough? Establishing Scientific Confidence in New Approach Methods
Abstract 240: Technical Framework for Enabling High Quality Measurements in New Approach Methodologies (NAMs)
Presenter: Elijah Petersen, National Institute of Standards and Technology
Abstract 313: Human Biological Relevance: Topical Toxicity Case Studies
Presenter: David Allen, Inotiv (contractor supporting NICEATM)
Session S405: Meeting at the Falls: ICATM Partner Updates
Nicole Kleinstreuer, NIEHS/NICEATM, was session co-chair
Abstract 319: ICCVAM Activities 5 Years into the Strategic Roadmap: Successes and Opportunities
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM
Session S406: Regulatory Acceptance of NAMs in EcoTox – How Do We Get There?
Kellie Fay, U.S. Environmental Protection Agency, was session co-chair
Abstract 120: Accepting the Separation of Toxicology and Statistics in New Approach Methodologies in Ecological Risk Assessment
Presenter: Sandy Raimondo, U.S. Environmental Protection Agency
Session S407: The 3Cs: Curating & Cultivating Change for Faster Integration of NAMs in Animal-Free Policy Making
Tala Henry, U.S. Environmental Protection Agency, was a panelist
Session S408: NAMs in Developmental Neurotoxicity – Difficult Road Leading to Change
Abstract 310: Generating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery
Presenter: Helena Hogberg, NIEHS/NICEATM
Abstract 588: Comparison of Dose-Response Modeling Pipelines for Developmental Neurotoxicity (DNT) New Approach Methods (NAMs)
Presenter: Kelly Carstens, U.S. Environmental Protection Agency
Session S410: NAMs in Practice: Fit-for-Purpose NGRA Across Sectors
Abstract 777: Regulatory Considerations on New Approach Methodologies for Developmental Immunotoxicity
Presenter: Suzanne Fitzpatrick, U.S. Food and Drug Administration
Next-Gen Education
Session S414: Comp-Tox in Education: Data Literacy for Next-Generation Risk Assessment
Abstract 20: International Computational Collaborations for Predictive Toxicology
Presenter: Kamel Mansouri, NIEHS/NICEATM
Ethics, Welfare, Policies, and Regulations
Session S427: Role of Roadmaps to Accelerate the Transition to Animal-Free Science
Abstract 312: Progress Towards Reducing Use of Animals in Chemical Testing and Adoption of New Methods to Evaluate the Safety of Chemicals and Medical Products in the United States
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM
Human-centered Biomedical Research
Session S432: Replacement in Action – Animal-Free Reagents, Methods, and Standards
Abstract 318: An Animal Component-Free Human Neuroprogenitor Cell Culture Model for High-Throughput Chemical Hazard Screening
Presenter: Megan Culbreth, U.S. Environmental Protection Agency
Session S435: Future of Multi-Scale Modelling and Simulation in Disease and Toxicology
Tom Knudsen, U.S. Environmental Protection Agency, was session co-chair
Abstract 632: Engineering a Computible Epiblast for In Silico Modeling of Developmental Toxicity
Presenter: Tom Knudsen, U.S. Environmental Protection Agency
21st Century Predictive Toxicology
Session S446: Chems-on-Chips: MPS for Organ Tox & Chemical Risk Assessment
Nicole Kleinstreuer, NIEHS/NICEATM, and Suzanne Fitzpatrick, U.S. Food and Drug Administration, were session co-chairs
Abstract 242: Technical Evaluation of an Oral Irritation Assay Using 3D Constructs
Presenter: Elijah Petersen, National Institute of Standards and Technology
Session S447: What’s in the Mix? New Approach Methods for Chemical Mixtures Risk Assessment
Suzanne Fitzpatrick, U.S. Food and Drug Administration, was session co-chair
Session S451: Physiologically-Based Pharmacokinetic Modelling for Chemical Risk Assessment
Abstract 198: Integrating Enzyme Variability Into PB-K Models of Chemicals and Metabolites
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM)
Abstract 592: Modeling Life Stage Toxicokinetic Variability for Effective Chemical Prioritization
Presenter: Barbara Wetmore, U.S. Environmental Protection Agency
Session S452: On the Runway: Interactive Predictive Tox Models
David Reif, National Institute of Environmental Health Sciences, was session co-chair
Abstract 179: ICE Data and Tools to Advance NAMs
Presenter: Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM)
Session S455: Progress in Quantifying Adverse Outcome Pathways to Support Next Generation Risk Assessment
Abstract 473: Methods2AOP: An International Collaboration Advancing AOP Key Event Descriptions
Presenter: Agnes Karmaus, Syngenta (NICEATM collaborator)
Session S458: Artificial Intelligence (AI): Current Advancements and Applications in Advancing the 3Rs
Nicole Kleinstreuer, NIEHS/NICEATM was session co-chair
Abstract 181: Deep Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms
Presenter: Alexandre Borrel, Inotiv (contractor supporting NICEATM)
Abstract 316: AI on the CompTox Continuum: Applications in Environmental Chemical Assessment
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM
Abstract: Democratizing Cheminformatics: Building the MoVIZ Pipeline for Intuitive Modeling and Visualization Using Low-Code Machine Learning
Presenter: Kamel Mansouri, NIEHS/NICEATM
Session S448: Tipping Point in Omics: Transcriptomic Points of Departure (tPODs) and QIVIVE in Regulatory Decision Making
Abstract 305: Leveraging In Vitro Transcriptomic Points of Departure in Chemical Safety Evaluation
Presenter: Logan Everett, U.S. Environmental Protection Agency
Session S454: Predictive Toxicology: Data, Development, Delivery, and Application
Ruchir Shah, Sciome (contractor supporting NICEATM), and Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM) were session co-chairs
Abstract 123: Curating Chemical Use and Exposure Predictions to Contextualize Chemical Hazard
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM)
Abstract 314: Developing Open-Access Datasets and Predictive Toxicology Tools
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM
Abstract 391: Update on the Use of New Approach Methodologies (NAMs) from the US Environmental Protection Agency’s Office of Pollution Prevention and Toxics
Presenter: Kellie Fay, U.S. Environmental Protection Agency
Abstract 476: Annotating High-Throughput Screening Assays: Facilitating Interpretation and Data Use
Presenter: Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM)
Session S459: What's New in Skin Sensitization?
Abstract 90: Evaluating Skin Sensitization Hazard of Diverse Chemicals Using GARDskin
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)
Abstract 274: Defined Approaches for Skin Sensitization for Diverse Chemical Sets
Presenter: Judy Strickland, Inotiv (contractor supporting NICEATM)
Abstract 600: The SARA-ICE Model for Predicting Skin Sensitization Potency
Presenter: Gavin Maxwell, Unilever (NICEATM collaborator)
Poster Presentations
Regulatory Acceptance and Global Harmonization
Abstract 292: Web Application to Predict Skin Sensitization Using Defined Approaches
Presenter: Kimberly To, Inotiv (contractor supporting NICEATM) - View To et al. poster
Abstract 302: Variability of In Vivo Toxicology Studies: Impact on NAMs
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM) - View Oyetade et al. poster
Next-Gen Education
Abstract 121: Integration of Technological Interference into Curated HTS Data
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM) - View Hull et al. poster
Ethics, Welfare, Policies, and Regulations
Abstract 293: Using NAMs to Address Variability and Susceptibility Across Populations
Presenter: Kimberly To, Inotiv (contractor supporting NICEATM) - View To et al. poster
Abstract 293: Opportunities for Encouraging the Consideration of Alternative Methods
Presenter: Jessie Carder, U.S. Department of Agriculture - View Carder et al. poster
Human-centered Biomedical Research
Abstract 92: A Working Group Supporting Adoption of MPS in Infectious Disease Research
Presenter: Amber Daniel, Inotiv (contractor supporting NICEATM) - View Daniel et al. poster
Abstract 241: Developing a Triculture In Vitro Human Gut Model to Evaluate Methods for Micro and Nano Plastics Toxicity Testing
Presenter: Elijah Petersen, National Institute of Standards and Technology
Abstract 275: Validation of the Electrophilic Allergen Screening Assay (EASA)
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM) - View Reinke et al. poster
Abstract 472: Insights from Profiling Transcription Factor Transactivation with CYP450 Metabolism Integration
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM) - View Karmaus et al. poster
21st Century Predictive Toxicology
Abstract 177: ChemMaps.com V2 - Exploring the Environmental Chemical Universe
Presenter: Alexandre Borrel, Inotiv (contractor supporting NICEATM) - View Borrel et al. poster
Abstract 178: Applying In Silico Toxicity Models Across the Tox21 Chemical Universe
Presenter: Alexandre Borrel, Inotiv (contractor supporting NICEATM) - View Lee et al. poster
Abstract 180: Expanding PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues
Presenter: Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM) - View Unnikrishnan et al. poster
Abstract 276: Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency
Presenter: Mathias Herzler, German Federal Institute for Risk Assessment (NICEATM collaborator) - View Herzler et al. poster
Abstract 575: Using In Vitro Data and PBPK Models to Predict Inhalation Toxicity
Presenter: Xiaoqing Chang, Inotiv (contractor supporting NICEATM) - View Chang et al. poster