On June 15, 2026, the National Institutes of Health (NIH) announced that moving forward, NICEATM will continue its important work as a division of the newly created NIH Office of Research Innovation, Validation, and Application (ORIVA). Soon, NICEATM content that you see on this webpage will be transitioned to the NIH ORIVA webpage. In the meantime, you can learn more about the new office and how it is structured.

https://ntp.niehs.nih.gov/go/niceatm-wc12

NICEATM and ICCVAM Agency Presentations at WC12

12th World Congress on Alternatives and Animal Use in the Life Sciences
August 27-31, 2023 – Niagara Falls, Canada

Visit the meeting website

Oral Presentations

Regulatory Acceptance and Global Harmonization

Session S400: Adversity Reinvented: Non-Animal Frameworks for Predictive & Protective Decision-Making

Abstract 162: In the Room Where It Happens: Assessing Pesticide Hazard
Presenter: Alison Harrill, U.S. Environmental Protection Agency

Session S402: Unlocking a New NAM-Based Paradigm: Transforming the Evaluation of Agrochemicals

Abstract 93: Defined Approaches for GHS Categorization to Assess Eye Irritation Potential of Agrochemical Formulations
Presenter: Amber Daniel, Inotiv (contractor supporting NICEATM)

Session S403: Advancements and Opportunities in the Replacement, Reduction and Refinement of Acute Toxicity Tests

Abstract 91: Development and Curation of an Acute Inhalation Toxicity Database
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)

Abstract 467: Replacing Animal Use in the Acute Toxicity "Six-Pack" for Industrial Chemicals and Pesticides: US Perspective
Presenter: Lindsay O'Dell, U.S. Environmental Protection Agency

Session S404: Is it Good Enough? Establishing Scientific Confidence in New Approach Methods

Abstract 240: Technical Framework for Enabling High Quality Measurements in New Approach Methodologies (NAMs)
Presenter: Elijah Petersen, National Institute of Standards and Technology

Abstract 313: Human Biological Relevance: Topical Toxicity Case Studies
Presenter: David Allen, Inotiv (contractor supporting NICEATM)

Session S405: Meeting at the Falls: ICATM Partner Updates

Nicole Kleinstreuer, NIEHS/NICEATM, was session co-chair

Abstract 319: ICCVAM Activities 5 Years into the Strategic Roadmap: Successes and Opportunities
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM

Session S406: Regulatory Acceptance of NAMs in EcoTox – How Do We Get There?

Kellie Fay, U.S. Environmental Protection Agency, was session co-chair

Abstract 120: Accepting the Separation of Toxicology and Statistics in New Approach Methodologies in Ecological Risk Assessment
Presenter: Sandy Raimondo, U.S. Environmental Protection Agency

Session S407: The 3Cs: Curating & Cultivating Change for Faster Integration of NAMs in Animal-Free Policy Making

Tala Henry, U.S. Environmental Protection Agency, was a panelist

Session S408: NAMs in Developmental Neurotoxicity – Difficult Road Leading to Change

Abstract 310: Generating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery
Presenter: Helena Hogberg, NIEHS/NICEATM

Abstract 588: Comparison of Dose-Response Modeling Pipelines for Developmental Neurotoxicity (DNT) New Approach Methods (NAMs)
Presenter: Kelly Carstens, U.S. Environmental Protection Agency

Session S410: NAMs in Practice: Fit-for-Purpose NGRA Across Sectors

Abstract 777: Regulatory Considerations on New Approach Methodologies for Developmental Immunotoxicity
Presenter: Suzanne Fitzpatrick, U.S. Food and Drug Administration

Next-Gen Education

Session S414: Comp-Tox in Education: Data Literacy for Next-Generation Risk Assessment

Abstract 20: International Computational Collaborations for Predictive Toxicology
Presenter: Kamel Mansouri, NIEHS/NICEATM

Ethics, Welfare, Policies, and Regulations

Session S427: Role of Roadmaps to Accelerate the Transition to Animal-Free Science

Abstract 312: Progress Towards Reducing Use of Animals in Chemical Testing and Adoption of New Methods to Evaluate the Safety of Chemicals and Medical Products in the United States
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM

Human-centered Biomedical Research

Session S432: Replacement in Action – Animal-Free Reagents, Methods, and Standards

Abstract 318: An Animal Component-Free Human Neuroprogenitor Cell Culture Model for High-Throughput Chemical Hazard Screening
Presenter: Megan Culbreth, U.S. Environmental Protection Agency

Session S435: Future of Multi-Scale Modelling and Simulation in Disease and Toxicology

Tom Knudsen, U.S. Environmental Protection Agency, was session co-chair

Abstract 632: Engineering a Computible Epiblast for In Silico Modeling of Developmental Toxicity
Presenter: Tom Knudsen, U.S. Environmental Protection Agency

21st Century Predictive Toxicology

Session S446: Chems-on-Chips: MPS for Organ Tox & Chemical Risk Assessment

Nicole Kleinstreuer, NIEHS/NICEATM, and Suzanne Fitzpatrick, U.S. Food and Drug Administration, were session co-chairs

Abstract 242: Technical Evaluation of an Oral Irritation Assay Using 3D Constructs
Presenter: Elijah Petersen, National Institute of Standards and Technology

Session S447: What’s in the Mix? New Approach Methods for Chemical Mixtures Risk Assessment

Suzanne Fitzpatrick, U.S. Food and Drug Administration, was session co-chair

Session S451: Physiologically-Based Pharmacokinetic Modelling for Chemical Risk Assessment

Abstract 198: Integrating Enzyme Variability Into PB-K Models of Chemicals and Metabolites
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM)

Abstract 592: Modeling Life Stage Toxicokinetic Variability for Effective Chemical Prioritization
Presenter: Barbara Wetmore, U.S. Environmental Protection Agency

Session S452: On the Runway: Interactive Predictive Tox Models

David Reif, National Institute of Environmental Health Sciences, was session co-chair

Abstract 179: ICE Data and Tools to Advance NAMs
Presenter: Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM)

Session S455: Progress in Quantifying Adverse Outcome Pathways to Support Next Generation Risk Assessment

Abstract 473: Methods2AOP: An International Collaboration Advancing AOP Key Event Descriptions
Presenter: Agnes Karmaus, Syngenta (NICEATM collaborator)

Session S458: Artificial Intelligence (AI): Current Advancements and Applications in Advancing the 3Rs

Nicole Kleinstreuer, NIEHS/NICEATM was session co-chair

Abstract 181: Deep Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms
Presenter: Alexandre Borrel, Inotiv (contractor supporting NICEATM)

Abstract 316: AI on the CompTox Continuum: Applications in Environmental Chemical Assessment
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM

Abstract: Democratizing Cheminformatics: Building the MoVIZ Pipeline for Intuitive Modeling and Visualization Using Low-Code Machine Learning
Presenter: Kamel Mansouri, NIEHS/NICEATM

Session S448: Tipping Point in Omics: Transcriptomic Points of Departure (tPODs) and QIVIVE in Regulatory Decision Making

Abstract 305: Leveraging In Vitro Transcriptomic Points of Departure in Chemical Safety Evaluation
Presenter: Logan Everett, U.S. Environmental Protection Agency

Session S454: Predictive Toxicology: Data, Development, Delivery, and Application

Ruchir Shah, Sciome (contractor supporting NICEATM), and Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM) were session co-chairs

Abstract 123: Curating Chemical Use and Exposure Predictions to Contextualize Chemical Hazard
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM)

Abstract 314: Developing Open-Access Datasets and Predictive Toxicology Tools
Presenter: Nicole Kleinstreuer, NIEHS/NICEATM

Abstract 391: Update on the Use of New Approach Methodologies (NAMs) from the US Environmental Protection Agency’s Office of Pollution Prevention and Toxics
Presenter: Kellie Fay, U.S. Environmental Protection Agency

Abstract 476: Annotating High-Throughput Screening Assays: Facilitating Interpretation and Data Use
Presenter: Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM)

Session S459: What's New in Skin Sensitization?

Abstract 90: Evaluating Skin Sensitization Hazard of Diverse Chemicals Using GARDskin
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)

Abstract 274: Defined Approaches for Skin Sensitization for Diverse Chemical Sets
Presenter: Judy Strickland, Inotiv (contractor supporting NICEATM)

Abstract 600: The SARA-ICE Model for Predicting Skin Sensitization Potency
Presenter: Gavin Maxwell, Unilever (NICEATM collaborator)

Poster Presentations

Regulatory Acceptance and Global Harmonization

Abstract 292: Web Application to Predict Skin Sensitization Using Defined Approaches
Presenter: Kimberly To, Inotiv (contractor supporting NICEATM) - View To et al. poster

Abstract 302: Variability of In Vivo Toxicology Studies: Impact on NAMs
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM) - View Oyetade et al. poster

Next-Gen Education

Abstract 121: Integration of Technological Interference into Curated HTS Data
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM) - View Hull et al. poster

Ethics, Welfare, Policies, and Regulations

Abstract 293: Using NAMs to Address Variability and Susceptibility Across Populations
Presenter: Kimberly To, Inotiv (contractor supporting NICEATM) - View To et al. poster

Abstract 293: Opportunities for Encouraging the Consideration of Alternative Methods
Presenter: Jessie Carder, U.S. Department of Agriculture - View Carder et al. poster

Human-centered Biomedical Research

Abstract 92: A Working Group Supporting Adoption of MPS in Infectious Disease Research
Presenter: Amber Daniel, Inotiv (contractor supporting NICEATM) - View Daniel et al. poster

Abstract 241: Developing a Triculture In Vitro Human Gut Model to Evaluate Methods for Micro and Nano Plastics Toxicity Testing
Presenter: Elijah Petersen, National Institute of Standards and Technology 

Abstract 275: Validation of the Electrophilic Allergen Screening Assay (EASA)
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM) - View Reinke et al. poster

Abstract 472: Insights from Profiling Transcription Factor Transactivation with CYP450 Metabolism Integration
Presenter: Victoria Hull, Inotiv (contractor supporting NICEATM) - View Karmaus et al. poster

21st Century Predictive Toxicology

Abstract 177: ChemMaps.com V2 - Exploring the Environmental Chemical Universe
Presenter: Alexandre Borrel, Inotiv (contractor supporting NICEATM) - View Borrel et al. poster

Abstract 178: Applying In Silico Toxicity Models Across the Tox21 Chemical Universe
Presenter: Alexandre Borrel, Inotiv (contractor supporting NICEATM) - View Lee et al. poster

Abstract 180: Expanding PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues
Presenter: Aswani Unnikrishnan, Inotiv (contractor supporting NICEATM) - View Unnikrishnan et al. poster

Abstract 276: Evaluation of Skin Sensitization Classification Rules to Reflect Human Potency
Presenter: Mathias Herzler, German Federal Institute for Risk Assessment (NICEATM collaborator) - View Herzler et al. poster

Abstract 575: Using In Vitro Data and PBPK Models to Predict Inhalation Toxicity
Presenter: Xiaoqing Chang, Inotiv (contractor supporting NICEATM) - View Chang et al. poster