https://ntp.niehs.nih.gov/go/niceatm-wc13

NICEATM and ICCVAM Presentations at WC13

13th World Congress on Alternatives and Animal Use in the Life Sciences
August 31-September 4, 2025 – Rio de Janeiro, Brazil

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Oral Presentations

Monday, September 1

Session 20: Artificial Intelligence to Reduce and Replace Animal Testing

9:30-11:00 a.m. — Plenary Room

Abstract 187: From Data to Decisions: AIs Role in Modern Toxicology
Presenter:
Nicole Kleinstreuer, NIH

Session 84: Transitioning to Animal-Free Chemical Safety Assessment

9:30-11:00 a.m. — Room 3

Abstract 493: Integrating New Approach Methods to Inform Chemical Safety Evaluation at the US EPA
Presenter:
Alison Harrill, EPA

Session 125: Ending 100 Years of Suffering: Regulatory Assessment of Acute Oral Toxicity Without Using Animals

11:30 a.m.-1:00 p.m. — Room 3

Abstract 101: The CATMoS Model: An In Silico Tool for Predicting Acute Oral Toxicity
Presenter:
Kamel Mansouri, NIEHS/NICEATM

Session 127: Regulatory Frameworks for Complex Endpoints

2:30-4:00 p.m. — Room 3

Abstract 607: Advancing Defined Approaches for Developmental Neurotoxicity Using the Integrated Testing and Assessment Framework Template
Presenter:
Helena Hogberg, NIEHS/NICEATM

Session 126: One Health, Many Models: Computational Approaches for Systemic Toxicities

2:30-4:00 p.m. — Room 4

Abstract 102: Assessing the Utility of the Collaborative Acute Toxicity Modeling Suite (CATMoS) from Ecological Risk Assessment to Human Health Hazard
Presenter:
Kamel Mansouri, NIEHS/NICEATM

Tuesday, September 2

Session 79: Using New Approach Methods (NAMs) to Derive Point-of-departures (PoD) for Next Generation Risk Assessment (NGRA) of Skin Sensitizers: Towards Regulatory Implementation

9:30-11:00 a.m. — Plenary Room

Abstract 92: Integrating NAMs for Quantitative Skin Sensitization Potency Assessment into Regulatory Frameworks: Experience from the Work in OECD TG 497
Presenter:
Emily Reinke, Inotiv (contractor supporting NICEATM)

Session 33: Generative AI for Drug Safety and Toxicology

9:30-11:00 a.m. — Room 2

Nicole Kleinstreuer, NIH, is session co-chair.

Abstract 87: Elucidation of Adverse Outcome Pathways for Compound-Induced Developmental Neurotoxicity Using Knowledge Graphs
Presenter:
Ricardo Scheufen Tieghi, NIEHS/NICEATM; University of North Carolina – Chapel Hill

Session 75: Update to OECD Guidance Document 34 on the Validation of Test Methods and Defined Approaches

9:30-11:00 a.m. — Room 3

Alison Harrill, EPA, is session co-chair.

Session 13: The Journey Towards Animal-free Systemic Toxicity Assessment for Cosmetics

11:30 a.m.-1:00 p.m. — Plenary Room

Abstract 149: Opportunities to Build Confidence in Use of NAMs for Systemic Toxicity
Presenter:
Alison Harrill, EPA

Session 143: Sailing the Seas of Validation: Challenges Encountered to Chart the Course Ahead

2:30-4:00 p.m. — Room 3

Abstract 155: Validation Powerlifting: Strengthening Confidence in NAMs with Flexibility and Fitness (for Purpose)
Presenter:
Amber Daniel, Inotiv (contractor supporting NICEATM)

Session 78: Unveiling Chemical Similarity in Computational Toxicology: Navigating Supervised and Unsupervised Approaches

2:30-4:00 p.m. — Room 4

Kamel Mansouri, NIEHS/NICEATM, is session co-chair.

Abstract 100: Understanding the Concept of Similarity and Its Applications to Toxicological Research and Risk Assessment
Presenter:
Kamel Mansouri, NIEHS/NICEATM

Wednesday, September 3

Session 62: One Science: The Continuum of New Approach Methodologies from Research to Regulation

9:30-11:00 a.m. — Room 2

Nicole Kleinstreuer, NIH, is session co-chair.

Abstract 287: Validation and Qualification Network (VQN) Public-Private Partnerships for Adoption and Implementation of New Approach Methodologies (NAMs)
Presenter:
Margaret Ochocinska, NIH

Session 113: Overcoming Barriers to Regulatory Uptake of Next Generation Risk Assessment

9:30-11:00 a.m. — Room 7

Abstract 747: Translating Experience into Progress: Advancing Regulatory Acceptance of NGRA
Presenter:
Warren Casey, NIEHS

Session 29: Building Confidence and Transparency into Validation Management and Peer Review

11:30 a.m.-1:00 p.m. — Room 3

Emily Reinke, Inotiv (contractor supporting NICEATM), is session co-chair.

Abstract 91: Ensuring Transparency and Rigor in the Peer Review of New Approach Methods for Skin Sensitization Assessment
Presenter:
Emily Reinke, Inotiv (contractor supporting NICEATM)

Session 15: Regulatory Experience Using a Weight of Evidence Approach to Reducing Testing on Animals

2:30-4:00 p.m. — Room 3

Abstract 103: Utilization of Non-Animal Approaches to Support Pesticide Assessments in the United States
Presenter:
Monique Perron, EPA

Thursday, September 4

Session 107: Accelerating Science to Policy Transfer of Animal Alternatives for Human and Environmental Safety Assessment: Lessons Learned and Ways Forward

9:30-11:00 a.m. — Room 6

Abstract 746: Leveraging Strategic Funding and Public-Private Partnerships to Establish Confidence in NAMs for Biomedical Research and Regulatory Testing
Presenter:
Warren Casey, NIEHS

Closing Keynote: Computational Intelligence and Biological Relevance: Innovating for a Safer Future
11:00 a.m.-12:30 p.m. — Plenary Room
Presenter:
Nicole Kleinstreuer, NIH

Poster Presentations

Poster viewing sessions are scheduled on Monday-Wednesday, September 1-3, from 2:00-2:30 p.m. in the Plenary Room. NICEATM authors are identified in boldface; ICCVAM authors are identified in italics.

Human Health - Replacement

Abstract 286: Understanding the Range of Phenotypic Responses for the Embryonic Zebrafish Developmental Toxicity Assay
Authors: Hill B, Hamm J
, Hsieh JH, Knapp B, Reinke E, Hogberg H, Ryan K

Abstract 288: Web Application to Classify and Subcategorize Skin Sensitizers Using Human Data
Authors: Unnikrishnan A, To K
, Herzler M, Germolec D, Reinke E, Kleinstreuer N

Abstract 297: Physiologically Based Pharmacokinetic (PBPK) Modeling Approach to Quantify Chemical Distribution in Brain and Adipose Compartments
Authors: Unnikrishnan A, Chang X, Kreutz A, LaPratt T, Hogberg H
, Sluka JP, Wambaugh J, Li D, Linakis M, Reinke E, Kleinstreuer N

Abstract 304: Development of TTC Values for Inhalable Substances
Authors:
Londenberg A, Api AM, Boislève F, Bowden AM, Collins S, Joshi K, Moustakasb H, Muldoon J, Patlewicz G, Zocher M, Singal M, Sadekar N, Escher S

Abstract 508: SARA-ICE: A Self-contained Model for Predicting a Human Relevant Point-of-Departure for Skin Sensitization
Authors: Reinke E
, Reynolds E, Reynolds J, Gilmour N, Marco B, Maxwell G, Kleinstreuer N

Environmental Health - Replacement

Abstract 90: Integrating Structure-based Chemical Taxonomies to Focus Queries of NAMs Data
Authors: Hull V, LaPratt T, Reinke E
, Kleinstreuer N

Abstract 609: Automating the Generation of QSAR Prediction Reporting Format Reports Using OPERA Models and KNIME
Authors:
Rangananth D, Moreira-Filho JT, Mansouri K, Kleinstreuer N

Abstract 706: Enhancing a Curated High-Throughput Screening Pipeline to Improve Toxicological Interpretations of In Vitro Data
Authors: Hull V, Hill B, Unnikrishnan A, Reinke E
, Kleinstreuer N, Hogberg H