NICEATM and ICCVAM Presentations at WC13
13th World Congress on Alternatives and Animal Use in the Life Sciences
August 31-September 4, 2025 – Rio de Janeiro, Brazil
NICEATM will be giving demonstrations of their online tools including the Integrated Chemical Environment, DASS App, SARA-ICE and others at World Congress on Wednesday, September 3 from 11:00 a.m. to 3:30 p.m. CAMERA, a new web resource for tracking and understanding validated methods, will also be demonstrated. Location and other details will be published here as they are available.
Oral Presentations
Monday, September 1
Session 20: Artificial Intelligence to Reduce and Replace Animal Testing
9:30-11:00 a.m. — Plenary Room
Abstract 187: From Data to Decisions: AIs Role in Modern Toxicology
Presenter: Nicole Kleinstreuer, NIH
Session 84: Transitioning to Animal-Free Chemical Safety Assessment
9:30-11:00 a.m. — Room 3
Abstract 493: Integrating New Approach Methods to Inform Chemical Safety Evaluation at the US EPA
Presenter: Alison Harrill, EPA
Session 125: Ending 100 Years of Suffering: Regulatory Assessment of Acute Oral Toxicity Without Using Animals
11:30 a.m.-1:00 p.m. — Room 3
Abstract 101: The CATMoS Model: An In Silico Tool for Predicting Acute Oral Toxicity
Presenter: Kamel Mansouri, NIEHS/NICEATM
Session 127: Regulatory Frameworks for Complex Endpoints
2:30-4:00 p.m. — Room 3
Abstract 607: Advancing Defined Approaches for Developmental Neurotoxicity Using the Integrated Testing and Assessment Framework Template
Presenter: Helena Hogberg, NIEHS/NICEATM
Session 126: One Health, Many Models: Computational Approaches for Systemic Toxicities
2:30-4:00 p.m. — Room 4
Abstract 102: Assessing the Utility of the Collaborative Acute Toxicity Modeling Suite (CATMoS) from Ecological Risk Assessment to Human Health Hazard
Presenter: Kamel Mansouri, NIEHS/NICEATM
Tuesday, September 2
Session 79: Using New Approach Methods (NAMs) to Derive Point-of-departures (PoD) for Next Generation Risk Assessment (NGRA) of Skin Sensitizers: Towards Regulatory Implementation
9:30-11:00 a.m. — Plenary Room
Abstract 92: Integrating NAMs for Quantitative Skin Sensitization Potency Assessment into Regulatory Frameworks: Experience from the Work in OECD TG 497
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)
Session 33: Generative AI for Drug Safety and Toxicology
9:30-11:00 a.m. — Room 2
Nicole Kleinstreuer, NIH, is session co-chair.
Abstract 87: Elucidation of Adverse Outcome Pathways for Compound-Induced Developmental Neurotoxicity Using Knowledge Graphs
Presenter: Ricardo Scheufen Tieghi, NIEHS/NICEATM; University of North Carolina – Chapel Hill
Session 75: Update to OECD Guidance Document 34 on the Validation of Test Methods and Defined Approaches
9:30-11:00 a.m. — Room 3
Alison Harrill, EPA, is session co-chair.
Session 13: The Journey Towards Animal-free Systemic Toxicity Assessment for Cosmetics
11:30 a.m.-1:00 p.m. — Plenary Room
Abstract 149: Opportunities to Build Confidence in Use of NAMs for Systemic Toxicity
Presenter: Alison Harrill, EPA
Session 143: Sailing the Seas of Validation: Challenges Encountered to Chart the Course Ahead
2:30-4:00 p.m. — Room 3
Abstract 155: Validation Powerlifting: Strengthening Confidence in NAMs with Flexibility and Fitness (for Purpose)
Presenter: Amber Daniel, Inotiv (contractor supporting NICEATM)
Session 78: Unveiling Chemical Similarity in Computational Toxicology: Navigating Supervised and Unsupervised Approaches
2:30-4:00 p.m. — Room 4
Kamel Mansouri, NIEHS/NICEATM, is session co-chair.
Abstract 100: Understanding the Concept of Similarity and Its Applications to Toxicological Research and Risk Assessment
Presenter: Kamel Mansouri, NIEHS/NICEATM
Wednesday, September 3
Session 62: One Science: The Continuum of New Approach Methodologies from Research to Regulation
9:30-11:00 a.m. — Room 2
Nicole Kleinstreuer, NIH, is session co-chair.
Abstract 287: Validation and Qualification Network (VQN) Public-Private Partnerships for Adoption and Implementation of New Approach Methodologies (NAMs)
Presenter: Margaret Ochocinska, NIH
Session 113: Overcoming Barriers to Regulatory Uptake of Next Generation Risk Assessment
9:30-11:00 a.m. — Room 7
Abstract 747: Translating Experience into Progress: Advancing Regulatory Acceptance of NGRA
Presenter: Warren Casey, NIEHS
Session 29: Building Confidence and Transparency into Validation Management and Peer Review
11:30 a.m.-1:00 p.m. — Room 3
Emily Reinke, Inotiv (contractor supporting NICEATM), is session co-chair.
Abstract 91: Ensuring Transparency and Rigor in the Peer Review of New Approach Methods for Skin Sensitization Assessment
Presenter: Emily Reinke, Inotiv (contractor supporting NICEATM)
Session 15: Regulatory Experience Using a Weight of Evidence Approach to Reducing Testing on Animals
2:30-4:00 p.m. — Room 3
Abstract 103: Utilization of Non-Animal Approaches to Support Pesticide Assessments in the United States
Presenter: Monique Perron, EPA
Session 138: Moving Forward Towards the Application of New Approach Methodologies for the Environmental Risk Assessment of Chemicals
2:30-4:00 p.m. — Room 207
Helena Hogberg, NIEHS/NICEATM, is session co-chair.
Thursday, September 4
Session 107: Accelerating Science to Policy Transfer of Animal Alternatives for Human and Environmental Safety Assessment: Lessons Learned and Ways Forward
9:30-11:00 a.m. — Room 6
Abstract 746: Leveraging Strategic Funding and Public-Private Partnerships to Establish Confidence in NAMs for Biomedical Research and Regulatory Testing
Presenter: Warren Casey, NIEHS
Closing Keynote: Computational Intelligence and Biological Relevance: Innovating for a Safer Future
11:00 a.m.-12:30 p.m. — Plenary Room
Presenter: Nicole Kleinstreuer, NIH
Poster Presentations
Poster viewing sessions are scheduled on Monday-Wednesday, September 1-3, from 2:00-2:30 p.m. in the Plenary Room. NICEATM authors are identified in boldface; ICCVAM authors are identified in italics.
Human Health - Replacement
Abstract 286: Understanding the Range of Phenotypic Responses for the Embryonic Zebrafish Developmental Toxicity Assay
Authors: Hill B, Hamm J, Hsieh JH, Knapp B, Reinke E, Hogberg H, Ryan K
Abstract 288: Web Application to Classify and Subcategorize Skin Sensitizers Using Human Data
Authors: Unnikrishnan A, To K, Herzler M, Germolec D, Reinke E, Kleinstreuer N
Abstract 297: Physiologically Based Pharmacokinetic (PBPK) Modeling Approach to Quantify Chemical Distribution in Brain and Adipose Compartments
Authors: Unnikrishnan A, Chang X, Kreutz A, LaPratt T, Hogberg H, Sluka JP, Wambaugh J, Li D, Linakis M, Reinke E, Kleinstreuer N
Abstract 304: Development of TTC Values for Inhalable Substances
Authors: Londenberg A, Api AM, Boislève F, Bowden AM, Collins S, Joshi K, Moustakasb H, Muldoon J, Patlewicz G, Zocher M, Singal M, Sadekar N, Escher S
Abstract 508: SARA-ICE: A Self-contained Model for Predicting a Human Relevant Point-of-Departure for Skin Sensitization
Authors: Reinke E, Reynolds E, Reynolds J, Gilmour N, Marco B, Maxwell G, Kleinstreuer N
Environmental Health - Replacement
Abstract 90: Integrating Structure-based Chemical Taxonomies to Focus Queries of NAMs Data
Authors: Hull V, LaPratt T, Reinke E, Kleinstreuer N
Abstract 609: Automating the Generation of QSAR Prediction Reporting Format Reports Using OPERA Models and KNIME
Authors: Rangananth D, Moreira-Filho JT, Mansouri K, Kleinstreuer N
Abstract 706: Enhancing a Curated High-Throughput Screening Pipeline to Improve Toxicological Interpretations of In Vitro Data
Authors: Hull V, Hill B, Unnikrishnan A, Reinke E, Kleinstreuer N, Hogberg H