Presentations at SOT 2024
Annual Meeting of the Society of Toxicology
March 10-14 – Salt Lake City, UT, USA
View meeting information on the SOT website
Continuing Education Courses
High-Throughput In Vitro–In Vivo Extrapolation for Predictive Toxicology
Presentation: In Vitro-In Vivo Extrapolation for New Approach Methodologies
Author: Chang X
Nix the Six: Strategies for Implementing Nonanimal Acute Toxicity Testing
Presentation: Acute Oral Toxicity Predictions for Environmental Safety Assessment Using CATMoS Models
Author: Mansouri K
Weight of Evidence Analysis and Problem Formulation for Chemical Risk Assessment: Fundamental Principles and Application through Case Examples
Anna Lowit, EPA, was course co-chair.
Presentation: Using a Weight of Evidence Approach to Optimize the Design of Animal Toxicity Studies
Author: Tan C
Putting Theory into Practice: Using Computational New Approach Methodologies in Next-Generation Risk Assessment
Presentation: Building Confidence in New Approach Methodologies to Support Next-Generation Risk Assessment
Author: Kleinstreuer N
Exhibitor-Hosted Session
ICCVAM Progress on Advancing Alternatives: Validation Report
Presented by National Institute of Environmental Health Sciences
NICEATM Presentations
NICEATM group member names are indicated in boldface in author lists.
Workshop Session: Revolutionizing Detection and Prevention of Neurotoxic Effects: Harnessing the Power of In Vitro and In Silico Approaches for Safer Drug Development and Environmental Monitoring
Helena Hogberg-Durdock (NIEHS/NICEATM) was session chair.
Abstract 1045: Identifying Seizure-Inducing Biological Targets: A Collaborative Approach Using AOP Networks, In Vitro Assays, and Computational Tools
Authors: Hogberg-Durdock H, Hamm J, Borrel A, Karmaus A, Lane T, Unnikrishnan A, Urbina F, Behl M
Platform Session: Mechanisms of Carcinogenicity
Abstract 2013: Modern In Vitro Imputation Modeling and Machine Learning to Predict Chemical Carcinogenicity
Authors: Borrel A, Tedla G, To KT, Hill B, Karmaus A, Wang A, Shah I, Luechtefeld T, Reif D, Allen DG, Kleinstreuer N
View Borrel et al poster
Poster Session: Human Exposure Assessment/Biomonitoring
Abstract 3325/Poster P448: Risk Assessment of Exposure to Triazole Fungicides by Human Biomonitoring and Mechanistic Data
Authors: de Aguiar Marciano L, Filipe Costa L, Silva Cardoso N, de Araújo Paula F, Pupin Silvério A, Kleinstreuer N, Martins I
View de Aguiar Marciano poster
Poster Session: New Approach Methods: General
Abstract 3495/Poster P731: Opportunities for Encouraging the Consideration of Alternative Methods
Authors: Marko S, Allen DG, Hogberg H, Oyetade O, Kleinstreuer N, Carder J
View Marko et al poster
Abstract 3506/Poster P742: Application of Skin Allergy Risk Assessment-Integrated Chemical Environment Defined Approach (SARA-ICE DA) to assess Skin Sensitization Potency of Isothiazolinone Compounds
Authors: Maxwell G, Reynolds J, Gilmour N, Strickland JA, Reinke EN, Germolec D, Truax J, Allen DG, Blaylock M, LaPratt T, Reynolds G, Kleinstreuer N
View Maxwell et al poster
Poster Session: Ocular Toxicology
Abstract 3460/Poster P636: Predicting GHS Hazard Classification for Eye Irritation/Corrosion Potential of Agrochemical Formulations Using Defined Approaches
Authors: Daniel A, van der Zalm AJ, Raabe H, Clippinger AJ, Kleinstreuer N, Allen DG
View Daniel et al poster
Symposium Session: Practical Applications of Machine Learning for Gaining Mechanistic Insights in Toxicology
Abstract 1088: Deep-Learning Profile QSAR Modeling to Impute In Vitro Assay Results and Predict Chemical Carcinogenesis Mechanisms
Author: Borrel A
Workshop Session: On the Edge of the NAMs Frontier: Pioneering Efforts toward Intra- and Internationally Harmonized Regulatory Applications of New Approach Methodologies
Amber Daniel (Inotiv, Inc., contractor supporting NICEATM) was session chair.
Workshop Session: Allergies Are More Than Skin Deep: Establishing Regulatory Test Methods for Respiratory Sensitization
Emily Reinke (Inotiv, Inc., contractor supporting NICEATM) was session chair.
Poster Session: Developmental and Juvenile Toxicology
Abstract 3850/Poster P353: PregPred: A Model to Predict the Developmental Toxicity Potential of Environmental Chemicals and FDA-Approved Drugs and Cosmetics
Authors: Scheufen Tieghi R, Rath MK, Moreira-Filho JT, Martin H, Beasley J, Hogberg HT, Kleinstreuer N, Muratov E
Poster Session: Respiratory Toxicology I
Abstract 4249/Poster P823: Curation and Characterization of a Reference Rat Acute Inhalation Toxicity Database
Authors: Allen DG, Hull V, Reinke EN, Daniel A, To KT, Karmaus A, Mansouri K, Kleinstreuer N
View Allen et al poster
Poster Session: Respiratory Toxicology II
Abstract 4292/Poster P867: In Vitro Evaluation of Inhalation Toxicity Induced by 2,3-Pentanedione Vapor Using a VITROCELL 48 2.0 Plus Exposure System and Air-Liquid Interface (ALI) Airway Model
Authors: Gwinn W, Roberts G, Yao P, Stout M, Ryan K, Waidyanatha, Gupta A, Pearson S, Richey J, Moyer B, Shaw J, Mukherjee S, Sparrow B
Poster Session: Neurotoxicity: Developmental I
Abstract 3818/Poster P320: Organophosphate Flame Retardants: A Comprehensive Toxicological Assessment
Authors: Sutherland V, Hogberg HT, Behl M, Hsieh J, Mansouri K, Mehta S, Roberts G, Ryan K, Taylor KW, Walker N, Walker VR, Witchey S, Rooney AA
Abstract 3819/Poster P321: Integrating Screening Level Developmental Neurotoxicity (DNT) Information of Chemicals in a New Approach Methods (NAMs) Battery to Identify Compounds for Future Study
Authors: McPherson CA, Combs P, Cushman J, Erickson J, Hsieh J, Hall L, Hogberg HT, Kendricks K, Sills R
Abstract 3822/Poster P324: OPFR Prioritization using the Developmental Neurotoxicity In Vitro Test Battery: An Update to OECD IATA Case Study
Authors: Oyetade OB, Chang X, Kreutz A, Hsieh J, Behl M, Sipes N, Allen DG, Hogberg HT
View Oyetade et al poster
Poster Session: New Approach Methods: In Vitro I
Abstract 4189/Poster P738: Testing of Regulatory-Relevant Chemicals for Skin and Respiratory Sensitization Hazard
Authors: Johnson V, Reinke EN, LaPratt T, Strickland J, To KT, Larne O, Johansson H, Forreryd A, Allen DG, Kleinstreuer N, Germolec D
View Johnson et al poster
Workshop Session: Applications of Annotations and Ontologies in Toxicology to Get Us on the Same Page for Maximizing Data Potential
Aswani Unnikrishnan (Inotiv, Inc., contractor supporting NICEATM) was session co-chair.
Workshop Session: Advancements in Utilizing Zebrafish-Based Behavioral Assays for Detecting Developmental Neurotoxicity and Understanding Associated Cellular and Molecular Changes
Abstract 1233: Behavioral Testing in Zebrafish Embryo as a Complementary Assay to Enhance the Developmental Neurotoxicity In Vitro Battery (DNT-IVB)
Authors: Hogberg H
Poster Session: Computational Toxicology I
Abstract 4354/Poster P139: SEAZIT-DIVER: A Web Application for Integrating and Visualizing Inter-laboratory Data on Substance-Induced Developmental Toxicity Phenotypes in Zebrafish Embryos
Authors: Hsieh J, Wang Z, Nolte S, Marvel S, Hill B, Hamm J, Roberts G, Schmitt, Ryan K
Abstract 4356/Poster P141: Modeling and Visualization (MoVIZ): Democratizing Cheminformatics with a User-friendly Guided Pipeline
Authors: Moreira-Filho J, Ranganath D, Conway M, Waidyanatha S, Collins B, Schmitt C, Kleinstreuer N, Mansouri K
Abstract 4366/Poster P151: Toxicological Data Gap Filling of Ingredients; Comparison of Machine Learning Based Imputation and Traditional QSAR Methods
Authors: Whitehead TM, Strickland J, Conduit GJ, Borrel A, Mucs D, Baskerville-Abraham I
Abstract 4383/Poster P168: Machine Learning-Based Development of Cytotoxicity Flags Within the Tox21/ToxCast Assays
Authors: Tedla G, Borrel A, Karmaus A, Hull V, To KT, Auman JT, Allen DG, Kleinstreuer N
Poster Session: Neurotoxicity: Developmental II
Abstract 4454/Poster P258: In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic Models
Authors: Kreutz A, Chang X, Lawless M, Shafer TJ, Wambaugh JF, Wetmore BA, Allen DG, Hogberg HT
View Kreutz et al poster
Poster Session: New Approach Methods: Computational
Abstract 4322/Poster P106: Curating Chemical Use Categories and Exposure Predictions to Inform Chemical Assessment
Authors: Hull V, LaPratt T, Karmaus A, To KT, Unnikrishnan A, Allen DG, Kleinstreuer N
View Hull et al poster
Abstract 4324/Poster P108: Application of the SARA-ICE Skin Sensitization Defined Approach to a Diverse Chemical Set - a Comparative Case Study
Authors: Reinke EN, LaPratt T, Strickland J, Germolec D, Truax J, Reynolds J, Reynolds G, Gilmour N, Allen DG, Maxwell G, Kleinstreuer N
View Reinke et al poster
Poster Session: Computational Toxicology II
Abstract 4385/Poster P172: Incorporating Ontologies into High Throughput Screening Assay Annotations to Increase Data Use and Interpretation
Authors: Hill B, Reinke EN, Auman JT, Unnikrishnan A, Allen DG, Kleinstreuer N
View Hill et al poster
Abstract 4392/Poster P179: Artificial Intelligence Approaches to Identify and Categorize Health-Relevant Research for Big Questions: Case Study of Cardiovascular Disease and Environmental Exposures
Authors: Krishna S, Beverly B, Walker VR, Kleinstreuer NC, Hannani A, Whately H, Trgovcich J, Rochester J, Sprowles J, Miller M, Tracy W, Sibrizzi C, Rooney AA
Abstract 4405/Poster P192: Seizure Predictions Using Adverse Outcome Pathway-Based Fast Interpretable Greedy-Tree Sums Modeling
Authors: Lane TR, Snyder S, Harris JS, Hamm J, Urbina F, Unnikrishnan A, Borrel A, Karmaus A, Behl M, Hogberg-Durdock H
Poster Session: Mathematical Modeling
Abstract 4425/Poster P213: IVIVE to Facilitate Animal-free Risk Assessment of Potential Developmental Toxicants
Authors: Chang X, Palmer J, Donley E, Reinke EN, Allen DG, Kleinstreuer N
View Chang et al poster
Abstract 4433/Poster P221: PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues
Authors: Unnikrishnan A, Chang X, Kreutz A, Hull V, Tedla G, Hogberg H, Sluka JP, Wambaugh J, Allen DG, Kleinstreuer N
View Unnikrishnan et al poster
Poster Session: Regulation/Policy
Abstract 4576/Poster P411: Advancing Flexibility for Defined Approach Guidelines: Developing Performance Standards to Incorporate Alternate Information Sources into the Defined Approach for Skin Sensitization Guideline
Authors: Sullivan K, Reinke EN, Macmillan DS, Raabe H, Germolec D, Allen DG, Choi E, Filipovska J, Kleinstreuer N
View Sullivan et al poster
Symposium Session: The Lifesaver or the Devil? Identifying Key Molecular-Signaling Pathways and Their Roles in Chronic Exposure-Induced Neurological Diseases
Helena Hogberg (NIEHS/NICEATM) was session chair.
Symposium Session: Current Status, Challenges, and Future Considerations: Advancing NAMs for Assessing Inhalation Toxicity
Xiaoqing Chang (Inotiv, Inc., contractor supporting NICEATM) was session chair.
Abstract 1303: In Vitro to In Vivo Extrapolation Application to Promote the Use of NAMs for Assessing Inhalation Toxicity
Author: Chang X
ICCVAM Committee Activities and Member Agency Presentations
ICCVAM Committee member names are indicated in boldface in author lists.
Platform Session: Mechanisms of Carcinogenicity
Abstract 2013: Modern In Vitro Imputation Modeling and Machine Learning to Predict Chemical Carcinogenicity
Authors: Borrel A, Tedla G, To KT, Hill B, Karmaus A, Wang A, Shah I, Luechtefeld T, Reif D, Allen DG, Kleinstreuer N
Poster Session: Human Exposure Assessment/Biomonitoring
Abstract 3325/Poster P448: Risk Assessment of Exposure to Triazole Fungicides by Human Biomonitoring and Mechanistic Data
Authors: de Aguiar Marciano L, Filipe Costa L, Silva Cardoso N, de Araújo Paula F, Pupin Silvério A, Kleinstreuer N, Martins I
Poster Session: Systems Biology and Toxicology
Abstract 3475/Poster P673: Profiling the Tox21 Library Compounds for Cytochrome P450 Inhibitory Activity
Authors: Sakamuru S, Travers J, Klumpp-Thomas C, Huang R, Witt KL, Ferguson SS, Simmons SO, Simeonov A, Xia M
Poster Session: New Approach Methods: General
Abstract 3495/Poster P731: Opportunities for Encouraging the Consideration of Alternative Methods
Authors: Marko S, Allen DG, Hogberg H, Oyetade O, Kleinstreuer N, Carder J
Abstract 3504/Poster P740: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity
Authors: Word L, Willis C, Padilla S, Weitekamp C, Carstens K, Everett L, Knapp B, Britton K, Judson R, Harrill J
Abstract 3506/Poster P742: Application of Skin Allergy Risk Assessment-Integrated Chemical Environment Defined Approach (SARA-ICE DA) to assess Skin Sensitization Potency of Isothiazolinone Compounds
Authors: Maxwell G, Reynolds J, Gilmour N, Strickland JA, Reinke EN, Germolec D, Truax J, Allen DG, Blaylock M, LaPratt T, Reynolds G, Kleinstreuer N
Abstract 3508/Poster P744: Predicting Renal Clearance of PFAS with a Human Kidney Proximal Tubule Tissue Chip and a Novel Physiologically-Based Kidney Model
Authors: Lin H, Sakolish C, Moyer HL, Ferguson SS, Stanko JP, Carmichael PL, Hewitt P, Hoffmann S, Rusyn I, Chiu WA
Poster Session: Ocular Toxicology
Abstract 3460/Poster P636: Predicting GHS Hazard Classification for Eye Irritation/Corrosion Potential of Agrochemical Formulations Using Defined Approaches
Authors: Daniel A, van der Zalm AJ, Raabe H, Clippinger AJ, Kleinstreuer N, Allen DG
Symposium Session: Botanical-Induced Toxicity: Liver Injury and Botanical Drug Interactions
Abstract 1067: Predicting Human Liver Injury and Botanical Drug Interactions with 3D Liver Microtissues and High-Throughput Transcriptomics
Author: Ferguson S
Workshop Session: On the Edge of the NAMs Frontier: Pioneering Efforts toward Intra- and Internationally Harmonized Regulatory Applications of New Approach Methodologies
Abstract 1097: Update on Collaborations to Support Implementation of In Vitro and Computational Approaches from the US EPA Office of Pollution Prevention and Toxics
Author: Lowit A
Poster Session: Biomarkers
Abstract 3278/Poster P398: Cell-Free DNA as a Biomarker of Toxicity and Tissue-Level Events in Cerebral Organoids
Authors: Silver BB, Gerrish K, Tokar EJ
Poster Session: PFAS I
Abstract 3541/Poster P828: Comprehensive Analysis of the Effects of PFAS on the Cellular Pathways and Potential Toxicities
Authors: Ooka M, Sakamuru S, Huang R, Ferguson S, Reif D, Simeonov A, Xia M
Abstract 3550/Poster P837: Evaluation of Per- and Polyfluoroalkyl Substances Hepatic Accumulation with Human 3D Liver Microtissues
Authors: Qu W, Liu J, Pearson A, Dunlap P, Waidyanatha S, Battelle B, Ferguson S
Abstract 3569/Poster P856: A Comparison of In Vitro and In Vivo Points of Departure with Human Biomonitoring Levels for Per- and Polyfluoroalkyl Substances (PFAS)
Authors: Judson R, Smith D, DeVito M, Wambaugh JF, Wetmore BA, Friedman KP, Padilla S, Weitekamp C, Patlewicz G, Thomas RS, Sayre RR, Olker J, Degitz S, Padilla S, Harrill J, Shafer T, Carstens K
Symposium Session: State-of-the-Art In Vitro Immune Modeling: The Beginning of a Journey toward AOPs and Improved Safety Assessment
Abstract 1119: Regulatory Considerations for Application of In Vitro Models of the Immune System to Safety and Risk Assessment
Author: Fitzpatrick S
Poster Session: Animal Models
Abstract 3759/Poster P247: Evaluation of Reproductive, Developmental, and Genetic Toxicities of Eugenol Using Caenorhabditis elegans Model
Authors: Chen T, Bekkala A, Yan J, Chen Y, Pan B, You L, Johnson F, Inselman A, Tyler T, Zhou T
Poster Session: Developmental and Juvenile Toxicology
Abstract 3850/Poster P353: PregPred: A Model to Predict the Developmental Toxicity Potential of Environmental Chemicals and FDA-Approved Drugs and Cosmetics
Authors: Scheufen Tieghi R, Rath MK, Moreira-Filho JT, Martin H, Beasley J, Hogberg HT, Kleinstreuer N, Tropsha A, Muratov E
Poster Session: Respiratory Toxicology I
Abstract 4249/Poster P823: Curation and Characterization of a Reference Rat Acute Inhalation Toxicity Database
Authors: Allen DG, Hull V, Reinke EN, Daniel A, To KT, Karmaus A, Mansouri K, Kleinstreuer N
Poster Session: Respiratory Toxicology II
Abstract 4294/Poster P869: Alveolus-on-a-Chip Reveals Distinctive Soot-Based Toxicity Biomarkers in Extracellular Vesicles
Authors: Huddleston ME, Ingram K, Jenkins M, Zaets A, Grogg M, Nelson MT
Abstract 4308/Poster P883: Peracetic Acid Effects on Human Bronchial Cells in an Air Liquid Interface
Authors: Burns ES, Olgun NS, Friend SA, McKinney WG, Sinsel EW, Reynolds JS, Leonard SS
Poster Session: Neurotoxicity: Developmental I
Abstract 3828/Poster P330: Re-testing of False Negative Compounds in New Approach Methods (NAMs) for Developmental Neurotoxicity Screening
Authors: Shafer TJ, Freudenrich TM, Wallace K, Carstens KE
Poster Session: Endocrine Toxicology
Abstract 3918/Poster P429: Effects of Polycarbonate Emissions Generated by 3-Dimensional Printing on Circulating Steroids and Anterior Pituitary Hormones
Authors: Krajnak K, Mandler K, McKinney W, Knepp A, Jackson M, Waugh S, Chapman P, Matheson J, Thomas T, Qian Y
Poster Session: New Approach Methods: In Vitro I
Abstract 4174/Poster P723: Donor-Dependent Responses to Acetaminophen in Human Primary Liver Cells Cultured in a Liver Microphysiological System
Authors: Shi Q, Ren L, Papineau KS, Sauld J, Ewart L, Avigan MI, Mendrick DL, Oliphant JH, Brown PC, Davis-Bruno KL, Frederic M, Patterson TA, Gamboa G, Schnackenberg LK, Sadrieh N
Abstract 4189/Poster P738: Testing of Regulatory-Relevant Chemicals for Skin and Respiratory Sensitization Hazard
Authors: Johnson V, Reinke EN, LaPratt T, Strickland J, To KT, Larne O, Johansson H, Forreryd A, Allen DG, Kleinstreuer N, Germolec D
Abstract 4193/Poster P742: A Novel Meso-Scale MPS Integrated Organ Platform to Evaluate Usnic Acid Kinetics, Organ Distribution and Cytotoxicity: A Case Study
Authors: McKim JM, Austin D, Sprando R, Hermansky S, Mattes W, Fitzpatrick S
Poster Session: New Approach Methods: In Vitro II
Abstract 4232/Poster P781: High-Throughput Transcriptomics (S1500+) Analysis of 2D and 3D HepaRG Liver Cells Highlight Their Utility as New Approach Methods in Chemical Hazard Assessment
Authors: Ramaiahgari S, Auerbach S, Saddler T, Waidyanatha S, Dixon D, Ferguson S
Abstract 4245/Poster P794: Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges
Authors: Jackson B, Minnema L, Wu Y, Schlosser C, Hofstra A, Carstens K, Shafer T
Symposium Session: Taking a Closer Look at Biological Evaluations for Ocular Medical Devices and Combination Products
Abstract 1190: Biocompatibility Assessment of Ophthalmic Medical Devices
Author: Bancos S
Platform Session: Molecular Mechanisms of Toxic Kidney Injury
Abstract 2055: In Vitro 3D Human Renal Proximal Tubule Microtissues for Nephrotoxicity Screening Studies
Authors: Pearson A, Travlos G, Roberts GK, Ferguson SS
Poster Session: Food Safety/Nutrition
Abstract 4514/Poster P335: Postmarket Safety Evaluation of the Food Packaging Impurity Trimethylolpropane
Authors: Crittenden P, Markley LC, Patton G
Abstract 4515/Poster P336: Development of a Database of Parameters for Evaluating the Biopersistence Potential of Substances
Authors: Souders CL, Rice PA, Kabadi SV
Abstract 4521/Poster P342: Cardiovascular Endpoints for Food Substances: Scoping Review
Authors: Park JK, Bandele O
Abstract 4522/Poster P343: Mutagenicity Predictions for Hazard Prioritization of Photoinitiators used in Printing Inks on the Exterior of Food Packaging
Authors: Markley L, Verma R, Arvidson K, Chen T, Bandele O
Abstract 4524/Poster P345: Updating the Safety Assessment of Oral Exposure to Anthraquinone and Vinylidene Chloride Based on a Review of Recently Published Toxicity Data
Authors: Holt L, Rattan S, Kabadi SV, Cheng T
Poster Session: Computational Toxicology I
Abstract 4356/Poster P141: Modeling and Visualization (MoVIZ): Democratizing Cheminformatics with a User-friendly Guided Pipeline
Authors: Moreira-Filho J, Ranganath D, Conway M, Waidyanatha S, Collins B, Schmitt C, Kleinstreuer N, Mansouri K
Abstract 4362/Poster P147: Transcriptomics Similarity Scoring Using Toxicological Databases to Anchor In Vivo Wildfire Smoke Exposure Data to Human Pulmonary Disease Signatures
Authors: Miller SL, Chappel J, Hickman E, Koval L, Kim Y, Rebuli M, Jaspers I, Rider C, Reif D, Rager JE
Abstract 4368/Poster P153: Assessing the Risks of Environmental Ototoxic Chemicals on Human Health: A Computational Modeling Perspective
Authors: Ruiz P, Luan S, Ji C, Zarus G
Abstract 4383/Poster P168: Machine Learning-Based Development of Cytotoxicity Flags Within the Tox21/ToxCast Assays
Authors: Tedla G, Borrel A, Karmaus A, Hull V, To KT, Auman JT, Allen DG, Kleinstreuer N
Poster Session: Neurotoxicity: Developmental II
Abstract 4458/Poster P262: Evaluating Two Analysis Methods for the Microelectrode Array Network Formation Assay
Authors: Mayil Vahanan M, Shafer TJ, Paul Friedman K, Carstens KE
Poster Session: New Approach Methods: Computational
Abstract 4317/Poster P101: Contextualizing Botanical Constituents In Silico Toxicology Results Using ADME Data
Authors: Embry MR, Nyguen A, Ferguson S, Waidyanatha S, Lawless M, Liu Y, Krzykwa J, Mitchell CA, Liu F, Fairman K, Li M, Roe A
Abstract 4320/Poster P104: Toward the Application of In Silico Tools to Chemical Mixtures of Environmental Incidences
Authors: Ji C, Prussia AJ, Mumtaz M, Ruiz P
Abstract 4322/Poster P106: Curating Chemical Use Categories and Exposure Predictions to Inform Chemical Assessment
Authors: Hull V, LaPratt T, Karmaus A, To KT, Unnikrishnan A, Allen DG, Kleinstreuer N
Abstract 4324/Poster P108: Application of the SARA-ICE Skin Sensitization Defined Approach to a Diverse Chemical Set - a Comparative Case Study
Authors: Reinke EN, LaPratt T, Strickland J, Germolec D, Truax J, Reynolds J, Reynolds G, Gilmour N, Allen DG, Maxwell G, Kleinstreuer N
Abstract 4341/Poster P125: Strain-Specific Mutagenicity Models for ICH M7 Submission
Authors: Gombar VK, Sedkyh AY, Green AJ, Ross A, Shah RR, Witt KW, Casey W
Poster Session: Computational Toxicology II
Abstract 4385/Poster P172: Incorporating Ontologies into High Throughput Screening Assay Annotations to Increase Data Use and Interpretation
Authors: Hill B, Reinke EN, Auman JT, Unnikrishnan A, Allen DG, Kleinstreuer N
Abstract 4392/Poster P179: Artificial Intelligence Approaches to Identify and Categorize Health-Relevant Research for Big Questions: Case Study of Cardiovascular Disease and Environmental Exposures
Authors: Krishna S, Beverly B, Walker VR, Kleinstreuer N, Hannani A, Whately H, Trgovcich J, Rochester J, Sprowles J, Miller M, Tracy W, Sibrizzi C, Rooney AA
Poster Session: Mathematical Modeling
Abstract 4425/Poster P213: IVIVE to Facilitate Animal-free Risk Assessment of Potential Developmental Toxicants
Authors: Chang X, Palmer J, Donley E, Reinke EN, Allen DG, Kleinstreuer N
Abstract 4433/Poster P221: PBPK Modeling to Predict Chemical Distribution in Brain and Adipose Tissues
Authors: Unnikrishnan A, Chang X, Kreutz A, Hull V, Tedla G, Hogberg H, Sluka JP, Wambaugh J, Allen DG, Kleinstreuer N
Poster Session: Bioinformatics
Abstract 4447/Poster P236: Transcriptomic Read-Across for Characterization of Chemical Mechanisms-of-Action
Authors: Mav D, Ross A, Balik-Meisner M, Phadke D, Auerbach S, Merrick BA
Poster Session: Regulation/Policy
Abstract 4576/Poster P411: Advancing Flexibility for Defined Approach Guidelines: Developing Performance Standards to Incorporate Alternate Information Sources into the Defined Approach for Skin Sensitization Guideline
Authors: Sullivan K, Reinke EN, Macmillan DS, Raabe H, Germolec D, Allen DG, Choi E, Filipovska J, Kleinstreuer N
Satellite Meetings
21st Century Toxicology – Updates and News from a Global Network.
Organized by the Johns Hopkins University Center for Alternatives to Animal Testing and Humane Society International/Animal-free Safety Assessment Collaboration
Speakers included ICCVAM members Nicole Kleinstreuer (NIEHS/NICEATM) and Alison Harrill (EPA). The program also featured updates from other ICCVAM member agencies and representatives from the International Cooperation on Alternative Text Methods.