Presentations at SOT 2022

Annual Meeting of the Society of Toxicology
March 27-31, 2022 – San Diego, CA, USA

View meeting information on the SOT website

Continuing Education Courses

AM02: Conceptual Models in Immunotoxicology: Leveraging Biological Knowledge, Alternative Approaches, and Computational Strategies for the Future of Risk Assessment

Presentation: OECD and Defined Approaches to Identify Contact Allergy: From Hazard to Quantitative Risk Assessment
Presenter: Kleinstreuer N

PM11: Next-Level Neurotoxicology: New Technologies to Advance Visualization of Spatial Molecular Alterations and Behavioral Phenotyping

Presentation: Microphysiological Systems of the CNS to Bridge between In Vivo and In Vitro
Presenter: Hogberg H

NICEATM Presentations

Symposium Session: New Approach Methods for Functional Developmental Neurotoxicity

SACATM member Tamara Tal (Helmholtz Centre for Environmental Research) was the session chair; Acting NICEATM Director Nicole Kleinstreuer was the session co-chair.

Platform Session: Risk Assessment

Abstract 2001: Modification of the Skin Allergy Risk Assessment (SARA) Model for GHS Classification and Its Application to Isothiazolinone Case Studies
Authors: Reynolds G, Reynolds J, Gilmour N, Strickland J, Germolec D, Truax J, Maxwell G, Kleinstreuer N

Poster Session: Autoimmunity/Hypersensitivity

Abstract 3387/Poster P579: Variability of Human Reference Data for Skin Sensitization
Authors: Strickland J, To K, Matheson J, Germolec D, Allen DG, Api AM, Gordon J, Ko H, Thierse H, Truax J, Kleinstreuer NC, Herzler M
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Poster Session: Neurotoxicity: General

Abstract 3300/Poster P450: A Systematic Review of COVID-19 Literature: Neurological Effects and SARS-CoV-2
Authors: Tsaioun K, Hogberg H, Breidenbach J, Elmore B, Filipovska J, Garcia-Reyero N, Hargreaves A, Joshi O, Macmillan DS, Omeragic E, Plant S, Ram R, Waspe J

Poster Session: Computational Toxicology I

Abstract 4000/Poster P698: Building Confidence in Alternative Methods through ICE
Authors: Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Choksi N, Daniel A, Hines D, Karmaus AL, McAfee E, Phillips J, Allen DG, Casey W, Kleinstreuer NC
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Abstract 4004/Poster P702: ICE Tools to Support Chemical Evaluations
Authors: Abedini J, Cook B, McAfee E, Phillips J, Rooney J, Allen DG, Mansouri K, Kleinstreuer NC
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Abstract 4005/Poster P703: Providing Context to In Vitro High-Throughput Screening Data via Annotation and Visualization Tools
Authors: Karmaus A, Rooney J, Ceger P, Abedini J, Phillips J, Bell S, Allen DG, Kleinstreuer NC
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Poster Session: Biological Modeling

Abstract 4041/Poster P740: Applying IVIVE to Determine Margins of Exposure for Potentially Cardiotoxic Chemicals
Authors: Krishna S, Chang X, Kleinstreuer N

Poster Session: Alternatives to Mammalian Models I

Abstract 3558/Poster P183: Variability in Reference Test Method Data and the Impact on NAM Evaluations
Authors: Allen DG, Rooney J, To K, Choksi N, Ceger P, Daniel A, Karmaus AL, Strickland J, Truax J, Casey W, Kleinstreuer N
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Workshop Session: Assay Gaps in the Developmental Neurotoxicity (DNT) New Approach Methodologies (NAMs) Battery for Human Health Risk Assessment

Helena Hogberg (NICEATM) was the session chair.

Abstract 1195: Assay Gaps in the Developmental Neurotoxicity (DNT) New Approach Methodologies (NAMs) Battery for Human Health Risk Assessment
Author: Hogberg H

Abstract 1198: Ontogeny of Neurotransmitter Function as an Endpoint for Developmental Neurotoxicity Assessment
Author: Hogberg H

Poster Session: Alternatives to Mammalian Models II

Abstract 4213/Poster P143: OrbiTox: A Computational Translational Discovery Platform for Data Mining and Read-Across
Authors: Ross A, Sedykh A, Gombar V, Kleinstreuer N, Merrick A, Shah R, Casey W

Poster Session: Cardiovascular Toxicology/Hemodynamics

Abstract 4370/Poster P324: A Comprehensive In Vitro Approach to Assess Environmental Chemical Hazard on Cardiovascular Diseases
Authors: Ramaiahgari S, Krishna S, Parham F, Auerbach S, Kleinstreuer N, Beverley B, Merrick A, Berridge B

Poster Session: Computational Toxicology II

Abstract 4654/Poster P700: OPERA Models for ADME Properties
Authors: Mansouri K, Choksi N, Chang X, Allen D, Kleinstreuer N
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Abstract 4683/Poster P729: High-Throughput Screening to Identify Chemical Cardiotoxic Potential
Authors: Krishna S, Berridge B, Kleinstreuer NC

Roundtable Session: Are Animal Studies Still the “Gold Standard” for Validating New Approach Methods?

Is the Time Near When We Can Begin to Consider a Paradigm Shift?
Presenter: Hogberg H

Poster Session: Safety Evaluation of Nonpharmaceutical Products

Abstract 4630/Poster P667: Application of Defined Approaches for Skin Sensitization to Agrochemical Products
Authors: Strickland J, Truax J, Corvaro M, Settivari R, Henriquez J, Germolec D, Gehen S, Allen D, Kleinstreuer N
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Poster Session: Late-Breaking 1

Abstract 5012/Poster P113: Developmental Neurotoxicity of Brominated and Organophosphorus Flame Retardants Using 3D hiPSC-Derived Brain Spheres
Authors: Virmani I, Kincaid B, Smirnova L, Hilscherova K, Hartung T, Hogberg HT

Poster Session: Late-Breaking 3

Abstract 5042/Poster P146: Application of In Vitro to In Vivo Extrapolation (IVIVE) to Informing In Vivo Point of Departure
Authors: Mumtaz M, Chang X, Allen DG, Kleinstreuer N
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ICCVAM Committee Activities

ICCVAM Committee member names are indicated in boldface in author lists.

Poster Session: PFAS I

Abstract 3089/Poster P192: In Vitro Hepatic Clearance of Per- and Polyfluoroalkyl Substances (PFAS)
Authors: Crizer D, Rice J, Zhou Z, Lavrich K, Wetmore B, Ferguson S, DeVito M, Merrick BA

Poster Session: Reproductive and Developmental Toxicology I

Abstract 3219/Poster P354: Application of In Silico and In Vitro Approaches for Evaluating Developmental and Reproductive Toxicity in Botanical Products
Authors: Sutherland V, Reinsalu L, Huang MC, Cronin MT, Embry M, Fitzpatrick S, Galli CL, Inselman A, Jia Q, Larson J, Mahony C, Pieters R, Ranganathan P, Rider C, Rogers J, Mitchell CA

Poster Session: Food Safety/Nutrition

Abstract 3398/Poster P757: Dietary Cadmium Exposure: A Systematic Review
Authors: Schaefer HR, Flannery B, Crosby L, Dominic O, Punzalan C, Farakos S, Pouillot R, Hoffman-Pennesi D, Dennis S, Fitzpatrick S, Middleton K

Poster Session: Air Pollution Toxicology II

Abstract 3481/Poster P103: Fuel Type Influences Developmental Toxicity of Burn Pit-Related Smoke in Zebrafish
Authors: Smoot J, Padilla S, Kim Y, Hill B, Knapp B, Lowery M, Oshiro W, Hazari MS, Hays M, Preston B, Jaspers I, Gilmour M, Farraj AK

Poster Session: DNA Damage and Repair

Abstract 3590/Poster P217: In Vitro Assessment of Cytotoxicity and Genotoxicity of Black Cohosh Extract and Its Constituents
Authors: Le Y, Li X, Chen S, Ning K, Guo X, Wu C, Manjanatha M, Mei N

Poster Session: Biological Modeling

Abstract 4059/Poster P758: A Dynamic Pharmacokinetic Model for Evaluating Exposures to PFOA and PFOS in Adults: Background and Site-Specific Exposure Evaluations
Authors: Welsh C, Siwakoti R, Compton J, Ruiz P, Fisher J

Roundtable Session: Tg.rasH2 Positive Controls: Added Value or No Longer Necessary?

Regulatory Perspective
Presenter: Brown P

Poster Session: Alternatives to Mammalian Models I

Abstract 3554/Poster P179: Application of Three-Dimensional (3D) HepaRG Spheroid Model for High-Throughput Genotoxicity Testing Using the CometChip Platform
Authors: Guo X, Seo J, Muskhelishvili L, Malhi P, He X, Manjanatha M, Mei N

Abstract 3568/Poster P193: A Benchmark Concentration Analysis Method for Larval Zebrafish Photomotor Response Data Using ToxCast Pipeline Software
Authors: Rowson Z, Setzer W, Paul Friedman K, Judson R, Padilla S

Poster Session: Air Pollution Toxicology III

Abstract 3547/Poster P170: Evaluation of Pulmonary Effects of 3D Printer Emissions from Acrylonitrile Butadiene Styrene Using an Air-Liquid Interface Model of Primary Normal Human-Derived Bronchial Epithelial Cells
Authors: Qian Y, Farcas MT, McKinney W, Coyle J, Orandle M, Mandler KW, Stefaniak AB, Bowers L, Battelli L, Battelli L, Richardson D, Hammer MA, Friend SA, Service S, Kashon M, Qi C, Hammond DR, Thomas TA, Matheson JA

Poster Session: Risk Assessment III

Abstract 3930/Poster P609: Race/Ethnicity and Age-Based Susceptibilities in Environmental Exposures to PFAS: A Literature Review of Exposures Associated with Altered Serum Lipids
Authors: Boone S, Ruiz P

Platform Session: Firefighter Health and PFAS-Containing Aqueous Film-Forming Foams (AFFF)

Abstract 2027: Untargeted Mass Spectrometric Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Rat Matrices following Exposure to Aqueous Film-Forming Foams (AFFFs)
Authors: Snyder R, O'Neal S, Fernando R, Waidyanatha S, Ferguson S, Roberts G, Fennell T

Abstract 2028: Comparative Accumulation and Biological Activity of Polyfluorinated Chemicals in Rats Varies with Exposure to Different Aqueous Film-Forming Foams
Authors: Huang M, Toy H, Waidyanatha S, Roberts G, Silinski M, Larson G, Chappell V, Parham F, Cora M, Gilliams J, Blake S, Fernando R, Elmore S, Sparrow B, Ferguson S

Workshop Session: How Can We Break Down the Silos of Epidemiology, Biological Mode of Action (MOA), and Statistical Modeling in Cancer Risk Assessment?

Anna Lowit (ICCVAM Co-chair, EPA) led the panel discussion.

Poster Session: Alternatives to Mammalian Models II

Abstract 4219/Poster P149: Panel of Bacterial Mutagenicity In Silico Models for Substructure-Based Analysis
Authors: Gombar V, Sedykh A, Shah R, Witt K, Casey W

Poster Session: Liver II: In Vitro

Abstract 4447/Poster P447: Analysis of Various Endpoints from Acetaminophen-Induced Liver Toxicity Study Using Emulate Liver-Chips
Authors: Shi Q, Arefin A, Ren L, Papineau K, Barnette DA, King E, Schnackenberg LK, Hawkes JJ, Mattes WB, Avigan M, Mendrick DL, Ronxhi J, Jang K

Poster Session: Kidney

Abstract 4482/Poster P485: Screening a Nephrotoxicant Library in Human Renal Proximal Tubule Epithelial Cells for Cytotoxicity and Glutathione Reactivity
Authors: Dunlap PE, Ramaiahgari S, Ferguson SS, Merrick BA

Poster Session: Computational Toxicology II

Abstract 4680/Poster P726: Toward Automation of High-Throughput Toxicology Image Data Analysis Using Deep Learning
Authors: Tandon A, Howard B, Ramaiahgari S, Ferguson SS, Merrick A, Shah R

Roundtable Session: Are Animal Studies Still the “Gold Standard” for Validating New Approach Methods?

Suzanne Fitzpatrick (ICCVAM Principal Agency Representative, FDA) was the session chair.

Abstract 1213: Are Animal Studies Still the “Gold Standard” for Validating New Approach Methods?
Author: Fitzpatrick S

Is US FDA Ready to Accept Nonanimal Data Only?
Presenter: Fitzpatrick S

Workshop Session: Educating 21st-Century Toxicologists: Making In Vitro and In Silico Approaches Part of the Curriculum

Abstract 1236: Educating 21st-Century Toxicologists and Risk Assessors: A Regulatory Perspective
Author: Scarano L

Poster Session: Mixtures

Abstract 4278/Poster P211: In Silico Prediction of Botanical Constituents’ Metabolites
Authors: Embry M, Ferguson S, Lawless M, Liu Y, Lumen A, Mitchell CA, Roe A, Waidyanatha S, Yan G

Abstract 4285/Poster P218: Assessment of Per- and Polyfluoroalkyl (PFAS) Mixtures: Real-World Applications
Authors: Mumtaz M, Mellard D, Rogers R, Scrunton K, Ulirsch G, Dyken J

Poster Session: Systems Biology

Abstract 4693/Poster P745: Applying External Biotransformation Capability to Quantitative High-Throughput Screening to Identify Compounds That Activate p53 Signaling after Metabolism
Authors: Ooka M, Zhao J, Shah P, Travers J, Klumpp-Thomas C, Xu X, Huang R, Ferguson S, Witt K, Smith-Roe SL, Simeonov A, Xia M

Workshop Session: The Use of Alternative Methods to Assess Chemical Toxicity and Risk in Military and Aerospace Exposure Scenarios

Emily Reinke (ICCVAM Co-chair, DoD) was the session chair.

Abstract 1292: The Use of Alternative Methods to Assess Chemical Toxicity and Risk in Military and Aerospace Exposure Scenarios
Author: Reinke E

Poster Session: Late-Breaking 1

Abstract 5007/Poster P108: Relative Characterization of Biological Responses to Perfluoroalkyl Substances (PFAS) and Aqueous Film-Forming Foams with In Vitro Hepatocyte Transcriptomics
Authors: Mauge-Lewis KA, Ramaiahgari S, Roberts G, Waidyanatha S, Fenton S, Phadke D, Balik-Meisner M, Sparrow B, Gorospe J, Ferguson S

Poster Session: Late-Breaking 3

Abstract 5043/Poster P147: US Army Public Health Center Toxicity Assessment and Fit-for-Purpose Testing of 1-Methyl-2,4,5-Trinitroimidazole (MTNI)
Authors: Adams VH, Reinke EN, East AG, Oyler KD

Satellite Meetings

21st Century Toxicology: Updates on Relevant Domestic and International Activities

Sponsored by the Johns Hopkins University Center for Alternatives to Animal Testing and Humane Society International

Presentation: NICEATM Update: Advances in Predictive Toxicology
Presenter: Helena Hogberg, NICEATM

Presentation: Advancing Alternative Methodologies at the FDA
Presenter: Suzanne Fitzpatrick, FDA

The program also featured updates from other ICCVAM member agencies and representatives from the International Cooperation on Alternative Text Methods.