Presentations at ASCCT 2024
Thirteenth Annual Meeting: American Society for Cellular and Computational Toxicology
October 28-30, 2024 - Research Triangle Park, NC, USA
NICEATM authors in bold; ICCVAM authors in bold italics
Oral Presentations
Revolutionizing Cardiotoxicity Assessment: A Unified Approach with New Methodology Approaches
Cardiotoxicity NAMs Across the Translational Toxicology Pipeline
Presenter: Kleinstreuer N
Breathe Easy: Expanding Applications for Inhalation NAMs to Fill Data Gaps and Provide Mechanistic Insights for Decision Making
Emily Reinke, Inotiv (contractor supporting NICEATM) is session chair
GARDAir Testing of Federal Agency Partners Chemicals of Concern
Presenter: Germolec D
Fit-for-purpose Evaluation and Applications of PBK Modeling and Quantitative In Vitro to In Vivo Extrapolation
Xiaoqing Chang, Inotiv (contractor supporting NICEATM) was session chair
In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic Models
Presenter: Kreutz A
Poster Presentations
Poster Session I: Monday, October 28
Abstract 70: Comparison of Data Analysis Approaches for a Microelectrode Array Neural Network Formation Assay
Authors: Vahanan MM, Shafer TJ, Carstens K
Abstract 57: High-Throughput Safety Pharmacology Screening to Better Understand Data-poor Chemicals
Authors: Rogers JD, Patlewicz G, Baker E, Bettmann A, Clippinger A, Paul Friedman K
Abstract 156: Nucleus and Cell Quantification of 3D Cell Painting Liver Spheroids with AI
Authors: Oktay A, Tandon A, Howard BE, Pearson A, Ferguson SS, Shah R
Abstract 161: Development of a Chemically Induced Long-term Potentiation Assay for Developmental Neurotoxicity Screening
Authors: Conley J, Harrill J, Carstens K, Shafer T
Poster Session II: Monday, October 28
Abstract 40: Incorporating Ontologies into High-Throughput Screening Assay Annotations to Facilitate Interpretation and Increase Data Use
Authors: Hill B, Auman JT, Unnikrishnan A, Karmaus A, Hogberg H, Reinke E, Kleinstreuer N
View Hill et al poster
Abstract 42: An Exploration of the Use of Hybrid Fingerprints in Generalized Read-across and their Impact on Predictive Performance for Selected In Vivo Toxicity Outcomes
Authors: Leary AJ, Patlewicz G, Shah I
Abstract 46: Harmonizing Tox Data to Enhance Confidence and Utility
Authors: Unnikrishnan A, To KT, Borrel A, Hull V, Daniel A, Reinke E, Kleinstreuer N
View Unnikrishnan et al poster
Abstract 47: The Integrated Chemical Environment (ICE): Advancing Data Availability and Computational Tool Accessibility for the Development, Evaluation, and Application of New Approach Methods
Authors: Reisfeld B, Borrel A, Chang X, Daniel A, Hill B, Hull V, To KT, Unnikrishnan A, Green A, McAfee E, Phillips J, Reinke E, Mansouri K, Kleinstreuer N
View Reisfeld et al poster
Abstract 51: Generating GD211-aligned Documentation for ToxCast to Support Assay Interpretation and Data Use
Authors: Ko A, Vahanan MM, Carstens K, Harrell A, Paul Friedman K, Feshuk M
Abstract 145: Integrating Mechanistic Data to Contextualize In Vivo Apical Observations Using the Developmental Neurotoxicity In Vitro Battery
Authors: Jackson B, Wu Y, Schlosser C, Hofstra A, Minnema L, Shafer T, Carstens K, Karmaus A
Poster Session III: Tuesday, October 29
Abstract 39: Structure-based Chemical Taxonomy to Focus Chemical Queries
Authors: LaPratt T, Hull V, Reinke E, Kleinstreuer N
View LaPratt et al poster
Abstract 41: DeTox: An In Silico Alternative to Animal Testing for Predicting Developmental Toxicity Potential
Authors: Scheufen Tieghi R, Moreira-Filho JT, Rath M, Wellnitz J, Martin HJ, Gates K, Hogberg-Durdock HT, Kleinstreuer N, Tropsha A, Muratov EN
Winner, Suzanne Fitzpatrick Student Travel Award
Abstract 62: Metabolic Similarity in Read-Across Prediction: A Case Study using Graph Convolutional Networks to Predict Genotoxicity Outcomes from Metabolic Networks
Authors: Hagan B, Patlewicz G, Shah I
Abstract 154: HuSSPred: an in-silico HPPT-based tool for Human Skin Sensitization Prediction
Authors: Scheufen Tieghi R, Moreira-Filho JT, Martin HJ, Wellnitz J, Otoch C, Rath M, Tropsha A, Muratov EN, Kleinstreuer N
Poster Session IV: Tuesday, October 29
Abstract 43: Development of a Curated Dataset to Facilitate the Derivation of Inhalation Threshold of Toxicological Concern (TTC) Values
Authors: Schwartz-Zoche M, Api AM, Joshi K, Collins S, Patlewicz G, Bowden AM, Boisleve F, Singal M, Giusti A, Sadekar N, Escher SE
Abstract 45: SARA-ICE: A Self-contained Model for Predicting a Human-relevant Point-of-departure for Skin Sensitization
Authors: Reinke E, Gilmour N, Reynolds G, Reynolds J, Marco B, Borrel A, Maxwell G, Kleinstreuer N
View Reinke et al SARA-ICE poster
Abstract 54: DASS App v2.0: Implementing OECD Guideline No. 497 Updates
Authors: To KT, Borrel A, Reinke E, Kleinstreuer N
View To et al poster – Winner, Outstanding Poster Presentation Award
Abstract 55: Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants
Authors: Oyetade O, Kreutz A, Chang X, Hsieh JH, Behl M, Reinke E, Hogberg H
Featured in a flash presentation, Tuesday, October 29
View Oyetade et al poster
Abstract 59: Class-based Hazard, Exposure, and Dose-response Assessment of Polyhalogenated Organophosphate Flame Retardants
Authors: Fies W, Luh J, Snow S, Martin E, Haber L, Bradley M, Reinke E, Borrel A, Hooker E, Bevington C, Gordon J, Cho T
Abstract 75: Mapping Tox21/ToxCast HTS Data to Key Characteristics of Carcinogens
Authors: Borrel A, Cuomo D, Hill B, Reisfeld B, Karmaus A, Osborne G, Feshuk M, Blake B, Druwe I, Wang A, Bisson W, Madia F, Facchin C, De Conti A, Rigutto G, McHale C, Smith M, Chiu WA, Kleinstreuer N
View Borrel et al poster
Abstract 77: Peer Review for Validation Studies - Building Confidence and Transparency into a New Validation Paradigm
Authors: Reinke E, Ulrey A, Hoffman S, Basketter D, Corsini E, Ashikaga T, Gerberick GF
Featured in a flash presentation, Tuesday, October 29
View Reinke et al peer review poster
Abstract 80: Defined Approaches for Predicting GHS and EPA Eye Irritation Classification of Agrochemicals
Authors: Daniel A, van der Zalm A, Raabe H, Clippinger A, Reinke E, Allen D, Kleinstreuer N
Featured in a flash presentation, Tuesday, October 29
View Daniel et al peer review poster – Winner, Outstanding Poster Presentation Award