Generalized Read-Across (GenRA) application
Read-across is a computational technique that uses toxicity data from one or more known (source) chemicals to predict toxicity for another (target) chemical, usually but not always on the basis of structural similarity. EPA’s Generalized Read-Across (GenRA) application is a standalone tool linked to the CompTox Chemicals Dashboard that performs read-across algorithmically, helping researchers to make informed decisions about chemicals with little toxicity data available.
GenRA had two major updates during 2022-2023.
- In September 2022, a new update allowed users to evaluate the relevance of similar substances using predicted physical property information. It provided predictions of toxicity and bioactivity that users could download for further analysis.
- Version 3.2 was released in March 2023. This update included data updates and over 30 minor improvements and bug fixes. Improved indexing in this release enabled increased processing speed.
In 2023, EPA presented virtual training on GenRA. Approximately 725 people attended the main session and 215 attended the breakouts, representing a record for attendance at an EPA NAMs training session. Additional training resources for GenRA are available on the EPA NAMs Training webpage.