DASS App for skin sensitization prediction using defined approaches
In June 2021, OECD issued Guideline 497, Defined Approaches on Skin Sensitisation, the first internationally harmonized guideline to describe a non-animal approach to predict skin sensitization potential. In March 2023, NICEATM launched the DASS App, which computationally applies the defined approaches outlined in Guideline 497 through a user-friendly interface (To et al. 2024). The user uploads data from the test methods used in the defined approach to the web application, which then generates skin sensitization predictions for chemicals of interest. The user selects the analysis variables, and the application dynamically provides feedback about the user’s data set to identify problematic data values. This open-access web-based implementation of internationally harmonized regulatory guidelines for an important public health endpoint is designed to support broad user uptake and consistent, reproducible application.