Acute systemic toxicity tests identify chemicals that could cause illness or death immediately or shortly after a single exposure. Webinars in this series explored and discussed alternative approaches that could replace, reduce, or refine the use of animals for identifying chemicals that may cause acute systemic toxicity when inhaled.
Participants in this webinar series (1) reviewed the regulatory guidelines to define when and how acute systemic toxicity data are used for assessing inhalation toxicity hazard potential; (2) reviewed existing alternative approaches for identifying chemicals likely to cause acute systemic toxicity via inhalation, which could include mechanism-based models, in vitro and in silico approaches; and (3) identified mechanisms of acute toxicity that may constitute key events in adverse outcome pathways for acute inhalation toxicity.
The webinar series steering committee was comprised of members from government and nongovernment stakeholder organizations including NICEATM, PETA International Science Consortium Ltd., The Dow Chemical Company, Simulations Plus, Inc., the Netherlands Organisation for Applied Scientific Research, and the U.S. Environmental Protection Agency (EPA).
Federal Register notice announcing the webinar series (March 18, 2016) — View as a webpage
Webinar 1: Tuesday, March 29
Current Testing Practices: Regulatory Requirements and Non-regulatory Testing
Speakers: Jon Hotchkiss, Ph.D., The Dow Chemical Company; Ian Indans, United Kingdom Chemicals Regulation Directorate
PubMed abstract of Sewell et al. (2015) paper on "evident toxicity" mentioned in webinar
Webinar 2: Tuesday, April 26
State-of-the-science, Practical Application, and Dosimetry Considerations for In Vitro and Ex Vivo Methods
Speakers: Marianna Gaca, Ph.D., British American Tobacco; Annie Jarabek, Ph.D., EPA
Webinar 3: Thursday, May 26
State-of-the-science and Practical Application of In Silico Methods
Speakers: Grace Patlewicz, Ph.D., EPA; Dan Wilson, Ph.D., The Dow Chemical Company
Webinar 4: Tuesday, June 28
GHS Additivity Approach to Classify Mixtures Based on Ingredient Toxicity
Speaker: Marco Corvaro, Ph.D., Dow AgroSciences
Webinar 5: Tuesday, July 12
Adverse Outcome Pathways
Speakers: Mathieu Vinken, Ph.D., Free University of Brussels, Belgium; Barbara Buckley, Ph.D., EPA
Webinar 6: Thursday, September 8
21st Century Testing Approaches
Speakers: Kelly BéruBé, Ph.D., Cardiff University; Dan Huh, Ph.D., University of Pennsylvania