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TDMS Study 96003-04 Pathology Tables

NTP Experiment-Test: 96003-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01
Route: GAVAGE                                                                                                     Time: 13:45:38

                                                          FINAL#1/MICE




       Facility:  BIORELIANCE

       Chemical CAS #:  106-95-6

       Lock Date:  10/18/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96003-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:45:38    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:FVB/N FEMALE                         VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           14                                                               
                                                                                                                                    
  Animals Examined Microscopically                    15           15                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)                                                             
      Hepatocyte, Necrosis, Focal                      2 (13%)      2 (13%)                                                         
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                      2 (13%)      2 (13%)                                                         
      Hepatocyte, Vacuolization Cytoplasmic, Focal     2 (13%)      3 (20%)                                                         
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                               1 (7%)                                                          
      Kupffer Cell, Hyperplasia, Diffuse                            1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)                                                             
      Atrophy                                          2 (13%)      2 (13%)                                                         
      Subcapsular, Hyperplasia, Focal                  8 (53%)      9 (60%)                                                         
      Zona Reticularis, Vacuolization Cytoplasmic,                                                                                  
           Diffuse                                    12 (80%)     13 (87%)                                                         
      Zona Reticularis, Vacuolization Cytoplasmic,                                                                                  
           Focal                                       2 (13%)      2 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:45:38    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:FVB/N FEMALE                         VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)                                                             
      Hemorrhage, Focal                                             2 (13%)                                                         
      Inflammation, Acute, Focal                                    1 (7%)                                                          
      Inflammation, Chronic Active, Focal                           1 (7%)                                                          
   Uterus                                             (15)         (15)                                                             
      Hydrometra                                       2 (13%)      1 (7%)                                                          
      Endometrium, Hyperplasia, Cystic                14 (93%)     15 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (15)         (15)                                                             
      Hematopoietic Cell Proliferation                15 (100%)    15 (100%)                                                        
      Pigmentation                                    15 (100%)    14 (93%)                                                         
      Lymphoid Follicle, Hyperplasia                   1 (7%)                                                                       
   Thymus                                             (15)         (14)                                                             
      Atrophy, Focal                                   4 (27%)      3 (21%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)                                                             
      Alveolar Epithelium, Hyperplasia, Focal          1 (7%)                                                                       
      Alveolus, Hemorrhage, Focal                      1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:45:38    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:FVB/N FEMALE                         VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)                                                             
      Renal Tubule, Dilatation, Focal                  2 (13%)      2 (13%)                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:45:38    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:FVB/N MALE                           VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15                                                               
  Early Deaths                                                                                                                      
    Dosing Accident                                                 1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           14                                                               
                                                                                                                                    
  Animals Examined Microscopically                    15           15                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                       (1)                                                              
      Epithelium, Hyperplasia, Diffuse                              1 (100%)                                                        
      Muscularis, Periesophageal Tissue,                                                                                            
          Inflammation, Chronic Active, Focal                       1 (100%)                                                        
   Liver                                              (15)         (15)                                                             
      Tension Lipidosis                                             1 (7%)                                                          
      Hepatocyte, Necrosis, Focal                      1 (7%)       1 (7%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic, Focal     1 (7%)                                                                       
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                  3 (20%)      2 (13%)                                                         
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic, Focal                           1 (7%)                                                                       
      Serosa, Mineralization, Focal                    1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (14)                                                             
      Atrophy                                         15 (100%)    14 (100%)                                                        
      Hypertrophy, Focal                              13 (87%)     14 (100%)                                                        
      Subcapsular, Hyperplasia, Focal                  1 (7%)                                                                       
   Thyroid Gland                                      (15)         (15)                                                             
      Ectopic Thymus                                   1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:45:38    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:FVB/N MALE                           VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (2)          (2)                                                              
      Ectasia                                          2 (100%)     2 (100%)                                                        
      Infiltration Cellular, Focal, Lymphocyte                      1 (50%)                                                         
   Testes                                             (15)         (15)                                                             
      Germinal Epithelium, Degeneration, Focal         2 (13%)      2 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mediastinal                            (14)         (15)                                                             
      Hyperplasia                                      1 (7%)                                                                       
   Spleen                                             (15)         (15)                                                             
      Hematopoietic Cell Proliferation                15 (100%)    13 (87%)                                                         
      Pigmentation                                    11 (73%)     11 (73%)                                                         
      Lymphoid Follicle, Atrophy                                    1 (7%)                                                          
   Thymus                                             (15)         (15)                                                             
      Atrophy, Diffuse                                              1 (7%)                                                          
      Atrophy, Focal                                   2 (13%)      3 (20%)                                                         
      Hyperplasia, Focal                                            1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)                                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Focal                                1 (7%)       1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:45:38    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:FVB/N MALE                           VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)                                                             
      Hemorrhage, Focal                                             1 (7%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          1 (7%)       1 (7%)                                                          
      Mediastinum, Inflammation, Acute, Focal                       1 (7%)                                                          
      Perivascular, Infiltration Cellular, Focal,                                                                                   
           Lymphocyte                                               1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)                                                             
      Renal Tubule, Degeneration, Focal                             1 (7%)                                                          
      Renal Tubule, Dilatation, Diffuse                1 (7%)                                                                       
      Renal Tubule, Dilatation, Focal                  1 (7%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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