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https://ntp.niehs.nih.gov/go/2629

TR 341 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           NITROFURANTOIN


NTP Experiment-Test: 05051-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 14:13:36




       Facility:  Southern Research Institute

       Chemical CAS #:  67-20-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              19            4            2                                                  
    Moribund                                          12            9           11                                                  
  Survivors                                                                                                                         
    Dead                                                            1                                                               
    Terminal Sacrifice                                19           36           37                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (41)         (39)         (42)                                                
      Dilatation                                       2 (5%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                                           1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Necrosis, Multifocal                             1 (2%)       2 (4%)       2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       1 (2%)                                                                       
      Sinusoid, Infiltration Cellular,                                                                                              
          Polymorphonuclear                           17 (34%)                                                                      
   Mesentery                                          (21)         (2)          (8)                                                 
      Cyst                                             1 (5%)                                                                       
      Hemorrhage, Focal                                1 (5%)                                                                       
      Inflammation, Acute, Multifocal, Suppurative    14 (67%)                                                                      
      Inflammation, Focal, Subacute                    1 (5%)                                                                       
      Fat, Necrosis, Focal                             4 (19%)      1 (50%)      3 (38%)                                            
   Pancreas                                           (47)         (50)         (50)                                                
      Abscess                                          1 (2%)                                                                       
      Atrophy                                          3 (6%)       1 (2%)       2 (4%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
      Duct, Cyst                                       1 (2%)                    2 (4%)                                             
   Stomach, Forestomach                               (49)         (49)         (50)                                                
      Hyperkeratosis                                   1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Acute, Focal, Suppurative          1 (2%)                                                                       
      Ulcer                                            1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (49)         (49)         (49)                                                
      Edema                                                                      1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                    1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                       4 (8%)                                             
      Degeneration, Fatty                              1 (2%)                                                                       
      Spindle Cell, Hyperplasia                        3 (6%)      41 (82%)     45 (90%)                                            
   Adrenal Gland, Medulla                             (48)         (49)         (49)                                                
      Hyperplasia                                      1 (2%)       2 (4%)       2 (4%)                                             
   Pituitary Gland                                    (48)         (44)         (49)                                                
      Pars Distalis, Angiectasis                       1 (2%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Hyperplasia                                    3 (7%)       2 (4%)                                             
   Thyroid Gland                                      (48)         (49)         (50)                                                
      Follicle, Cyst                                   2 (4%)                    2 (4%)                                             
      Follicle, Degeneration, Cystic                   3 (6%)                                                                       
      Follicle, Hyperplasia, Cystic                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                                                                           
      Cyst                                             1 (100%)                                                                     
   Ovary                                              (50)         (50)         (50)                                                
      Abscess                                         18 (36%)                                                                      
      Atrophy                                                      48 (96%)     49 (98%)                                            
      Cyst                                            14 (28%)     10 (20%)     15 (30%)                                            
      Hemorrhage                                       1 (2%)       1 (2%)       3 (6%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                                2 (4%)       3 (6%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Hydrometra                                       2 (4%)                    1 (2%)                                             
      Hyperplasia, Cystic                             49 (98%)     49 (98%)     49 (98%)                                            
      Inflammation, Acute, Suppurative                11 (22%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (49)                                                
      Deep Cervical, Inflammation, Acute, Focal,                                                                                    
           Suppurative                                 2 (4%)                                                                       
      Iliac, Hyperplasia                               2 (4%)                                                                       
      Mediastinal, Congestion                          1 (2%)                                                                       
      Mediastinal, Hyperplasia                         1 (2%)                                                                       
      Renal, Congestion                                             1 (2%)                                                          
      Renal, Hyperplasia                               6 (12%)                                                                      
   Lymph Node, Mandibular                             (50)         (50)         (45)                                                
      Congestion                                       1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute, Focal, Suppurative          1 (2%)                                                                       
   Lymph Node, Mesenteric                             (45)         (45)         (48)                                                
      Angiectasis                                      3 (7%)                                                                       
      Hyperplasia                                      2 (4%)                                                                       
   Spleen                                             (49)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                21 (43%)      4 (8%)       2 (4%)                                             
      Hemorrhage                                                    1 (2%)                                                          
   Thymus                                             (47)         (48)         (48)                                                
      Cyst                                                          1 (2%)       2 (4%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Mediastinum, Inflammation, Acute, Suppurative    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (48)                                                
      Duct, Cyst                                       3 (6%)                    3 (6%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Alopecia                                         2 (4%)                    1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
      Inflammation, Focal, Granulomatous                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (2)                                                 
      Inflammation, Acute, Suppurative                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
      Compression                                                   1 (2%)       1 (2%)                                             
      Hydrocephalus                                                 1 (2%)                                                          
      Inflammation, Acute, Multifocal, Suppurative                  1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                    1 (2%)                                             
      Hemorrhage, Focal                                             1 (2%)       1 (2%)                                             
      Infiltration Cellular, Multifocal, Histiocyte    1 (2%)                                                                       
      Inflammation, Acute, Suppurative                 1 (2%)                                                                       
      Inflammation, Multifocal, Subacute              25 (50%)     19 (38%)     19 (38%)                                            
      Inflammation, Subacute                           1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    3 (6%)                                             
      Mediastinum, Inflammation, Acute, Suppurative    2 (4%)                                                                       
   Nose                                               (48)         (50)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (5)          (1)                                                 
      Hemorrhage                                                    1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Fibrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Metaplasia, Focal, Osseous                                                 2 (4%)                                             
      Nephropathy                                                   1 (2%)                                                          
      Cortex, Infarct                                               3 (6%)       1 (2%)                                             
      Cortex, Mineralization, Diffuse                               1 (2%)                                                          
      Medulla, Mineralization                                                    7 (14%)                                            
      Renal Tubule, Degeneration, Multifocal                                     1 (2%)                                             
      Renal Tubule, Dilatation                                      1 (2%)       1 (2%)                                             
      Renal Tubule, Necrosis, Multifocal               1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            3 (6%)       2 (4%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7           12            2                                                  
    Moribund                                          15            9           14                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           29           33                                                  
    Moribund                                                                     1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (45)         (37)                                                
      Hyperplasia                                                                1 (3%)                                             
   Intestine Large, Rectum                            (48)         (47)         (50)                                                
      Cyst                                             2 (4%)                    1 (2%)                                             
      Hyperplasia, Focal                                                         1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Inflammation, Subacute                           2 (4%)                    1 (2%)                                             
      Perforation                                                   1 (2%)                                                          
      Prolapse                                         3 (6%)       1 (2%)       2 (4%)                                             
   Intestine Small, Jejunum                           (49)         (45)         (49)                                                
      Cyst                                             1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                                           1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Fibrosis, Focal                                               1 (2%)                                                          
      Granuloma, Multiple                              1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Mixed Cell Focus                                              2 (4%)                                                          
      Necrosis, Multifocal                             1 (2%)       1 (2%)       1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
   Mesentery                                          (3)          (1)          (2)                                                 
      Inflammation, Acute, Multifocal, Suppurative     2 (67%)                                                                      
      Inflammation, Focal, Subacute                    1 (33%)                                                                      
      Thrombosis                                       1 (33%)                                                                      
   Stomach, Forestomach                               (49)         (48)         (49)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia                                      2 (4%)       1 (2%)                                                          
      Inflammation, Acute, Focal, Suppurative                       1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (48)         (49)                                                
      Mineralization                                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tooth                                              (10)         (12)         (4)                                                 
      Dysplasia                                       10 (100%)    12 (100%)     4 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Inflammation, Multifocal, Subacute               2 (4%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Hyperplasia, Focal                               1 (2%)                    2 (4%)                                             
      Spindle Cell, Hyperplasia                        5 (10%)      3 (6%)       3 (6%)                                             
      Spindle Cell, Hyperplasia, Focal                                           1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (48)         (49)                                                
      Hyperplasia                                      3 (6%)       6 (13%)      5 (10%)                                            
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (46)         (48)         (43)                                                
      Pars Distalis, Cyst                                                        1 (2%)                                             
   Thyroid Gland                                      (48)         (47)         (48)                                                
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Follicle, Cyst                                                1 (2%)       3 (6%)                                             
      Follicle, Degeneration                           1 (2%)       1 (2%)       1 (2%)                                             
      Follicle, Hyperplasia, Cystic                                 2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)                                                
      Atypia Cellular                                                           26 (52%)                                            
      Depletion Cellular                               1 (2%)       1 (2%)      15 (30%)                                            
      Granuloma Sperm                                               3 (6%)                                                          
   Penis                                              (2)          (8)          (1)                                                 
      Developmental Malformation                       2 (100%)     8 (100%)     1 (100%)                                           
   Preputial Gland                                    (9)          (2)          (4)                                                 
      Inflammation, Acute, Suppurative                 1 (11%)                                                                      
      Inflammation, Subacute                           5 (56%)                                                                      
      Duct, Cyst                                       6 (67%)      2 (100%)     4 (100%)                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Prostate                                           (49)         (50)         (50)                                                
      Inflammation, Acute, Suppurative                 4 (8%)       4 (8%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
   Seminal Vesicle                                    (6)          (4)          (1)                                                 
      Dilatation                                       3 (50%)      4 (100%)     1 (100%)                                           
      Inflammation, Acute, Suppurative                 2 (33%)                                                                      
      Inflammation, Chronic                            1 (17%)      1 (25%)                                                         
   Testes                                             (49)         (49)         (50)                                                
      Aspermatogenesis                                 1 (2%)       1 (2%)      16 (32%)                                            
      Atrophy                                                       1 (2%)                                                          
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Germinal Epithelium, Degeneration                             3 (6%)      23 (46%)                                            
      Seminiferous Tubule, Dilatation, Focal                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
      Anemia                                           1 (50%)                                                                      
   Lymph Node                                         (50)         (49)         (49)                                                
      Axillary, Hyperplasia                                                      1 (2%)                                             
      Deep Cervical, Hyperplasia                       1 (2%)                                                                       
      Iliac, Hyperplasia                               1 (2%)                    1 (2%)                                             
      Inguinal, Hyperplasia                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (46)         (44)                                                
      Angiectasis                                      6 (13%)                                                                      
      Ectasia                                                       1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
   Spleen                                             (50)         (49)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Atrophy                                                       3 (6%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                10 (20%)     11 (22%)      4 (8%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
   Thymus                                             (44)         (43)         (41)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Alopecia                                         4 (8%)       5 (10%)      3 (6%)                                             
      Alopecia, Multifocal                             3 (6%)                                                                       
      Fibrosis                                         7 (14%)      5 (10%)     12 (24%)                                            
      Fungus                                                        1 (2%)       1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                    2 (4%)                                             
      Inflammation, Acute, Suppurative                 2 (4%)       2 (4%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Focal, Granulomatous                            2 (4%)       1 (2%)                                             
      Inflammation, Focal, Subacute                    7 (14%)     12 (24%)      9 (18%)                                            
      Mineralization, Focal                            1 (2%)       1 (2%)       2 (4%)                                             
      Ulcer                                                         4 (8%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Hyperostosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       3 (6%)                                                                       
      Fibrosis, Multifocal                                          1 (2%)                                                          
      Infiltration Cellular, Multifocal, Histiocyte                 1 (2%)                                                          
      Inflammation, Multifocal, Subacute              32 (64%)     34 (68%)     30 (60%)                                            
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    2 (4%)                                             
   Nose                                               (42)         (44)         (48)                                                
      Hemorrhage                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Calculus Gross Observation                       1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)                                                                       
      Inflammation, Acute, Multifocal, Suppurative     1 (2%)                                                                       
      Metaplasia, Focal, Osseous                       1 (2%)                                                                       
      Nephropathy                                      3 (6%)                                                                       
      Cortex, Infarct                                                            1 (2%)                                             
      Cortex, Infarct, Focal                           1 (2%)       2 (4%)       1 (2%)                                             
      Medulla, Mineralization                                                   17 (34%)                                            
      Papilla, Necrosis                                1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05051-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:13:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Degeneration, Multifocal                        1 (2%)       1 (2%)                                             
      Renal Tubule, Dilatation                                                  14 (28%)                                            
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Hyperplasia, Focal                              1 (2%)                                                          
      Renal Tubule, Necrosis, Multifocal                                         1 (2%)                                             
      Renal Tubule, Nephropathy                        1 (2%)       1 (2%)                                                          
   Ureter                                             (1)                                                                           
      Inflammation, Acute, Suppurative                 1 (100%)                                                                     
   Urethra                                            (2)                                                                           
      Inflammation, Subacute, Suppurative              1 (50%)                                                                      
      Bulbourethral Gland, Dilatation                  1 (50%)                                                                      
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Calculus Gross Observation                       1 (2%)                                                                       
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Inflammation, Acute, Suppurative                 2 (4%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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