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TR 341 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           NITROFURANTOIN


NTP Experiment-Test: 05051-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 14:37:16




       Facility:  Southern Research Institute

       Chemical CAS #:  67-20-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              19            4            2                                                  
    Moribund                                          12            9           11                                                  
  Survivors                                                                                                                         
    Dead                                                            1                                                               
    Terminal Sacrifice                                19           36           37                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (41)         (39)         (42)                                                
   Intestine Large, Cecum                             (43)         (49)         (50)                                                
   Intestine Small, Ileum                             (44)         (47)         (50)                                                
   Intestine Small, Jejunum                           (45)         (48)         (50)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                         1 (2%)       1 (2%)       2 (4%)                                             
      Hepatocellular Adenoma                           1 (2%)       1 (2%)       7 (14%)                                            
      Ito Cell Tumor NOS                                            1 (2%)       1 (2%)                                             
   Mesentery                                          (21)         (2)          (8)                                                 
      Fibrosarcoma                                                               1 (13%)                                            
      Sarcoma                                                       1 (50%)      1 (13%)                                            
   Pancreas                                           (47)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Sarcoma                                                       1 (2%)                                                          
   Salivary Glands                                    (49)         (50)         (50)                                                
   Stomach, Forestomach                               (49)         (49)         (50)                                                
      Sarcoma                                                       1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Glandular, Fibrosarcoma, Metastatic,                                                                                          
          Mesentery                                                              1 (2%)                                             
   Stomach, Glandular                                 (49)         (49)         (49)                                                
      Sarcoma                                                       1 (2%)                                                          
   Tongue                                             (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Spindle Cell, Adenoma                                         1 (2%)                                                          
   Adrenal Gland, Medulla                             (48)         (49)         (49)                                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (47)         (50)         (49)                                                
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (48)         (44)         (49)                                                
      Pars Distalis, Adenoma                           3 (6%)       1 (2%)       2 (4%)                                             
   Thyroid Gland                                      (48)         (49)         (50)                                                
      Follicular Cell, Adenoma                         3 (6%)       1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (50)         (50)                                                
      Adenoma, Tubular                                                           5 (10%)                                            
      Cystadenoma                                                                1 (2%)                                             
      Cystadenoma, Papillary                           2 (4%)       1 (2%)                                                          
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                                   3 (6%)       1 (2%)                                             
      Hemangioma                                                    1 (2%)       1 (2%)                                             
      Mixed Tumor Benign                                                         4 (8%)                                             
      Neoplasm NOS                                                               1 (2%)                                             
   Uterus                                             (50)         (50)         (50)                                                
      Adenocarcinoma                                                1 (2%)       1 (2%)                                             
      Polyp Stromal                                    2 (4%)       2 (4%)       1 (2%)                                             
      Sarcoma Stromal                                                            2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (49)                                                
   Lymph Node, Mandibular                             (50)         (50)         (45)                                                
   Lymph Node, Mesenteric                             (45)         (45)         (48)                                                
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
   Spleen                                             (49)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (47)         (48)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (48)                                                
      Adenoacanthoma                                                             1 (2%)                                             
      Adenocarcinoma                                   5 (10%)      3 (6%)                                                          
      Adenocarcinoma, Multiple                                                   1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Benign                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (2)          (1)          (2)                                                 
      Fibrosarcoma, Metastatic, Mesentery                                        1 (50%)                                            
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
      Meningioma Benign                                             1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Mammary Gland                     1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Basal Cell Carcinoma, Metastatic, Skin                                     1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
      Mediastinum, Sarcoma                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (5)          (1)                                                 
      Adenocarcinoma                                   1 (50%)      1 (20%)                                                         
      Adenoma                                          1 (50%)      2 (40%)      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Sarcoma                                                       1 (2%)                                                          
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   1 (2%)       5 (10%)      6 (12%)                                            
      Lymphoma Malignant Lymphocytic                  11 (22%)     10 (20%)     17 (34%)                                            
      Lymphoma Malignant Mixed                                      4 (8%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          35          41                                                   
     Total Primary Neoplasms                           44          55          67                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15          15          22                                                   
     Total Benign Neoplasms                            17          17          27                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          27          31                                                   
     Total Malignant Neoplasms                         27          37          38                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           3                                                   
     Total Metastatic Neoplasm                          2           3           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           2                                                   
     Total Uncertain Neoplasms                                      1           2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7           12            2                                                  
    Moribund                                          15            9           14                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           29           33                                                  
    Moribund                                                                     1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (50)                                                
   Intestine Small, Ileum                             (47)         (43)         (47)                                                
   Intestine Small, Jejunum                           (49)         (45)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         8 (16%)      6 (12%)      7 (14%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)       4 (8%)       3 (6%)                                             
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)       1 (2%)                                             
   Mesentery                                          (3)          (1)          (2)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (50%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Stomach, Forestomach                               (49)         (48)         (49)                                                
      Fibrosarcoma                                     1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Spindle Cell, Carcinoma                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (48)         (49)                                                
                                                             Page   7                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Malignant                       2 (4%)                                                                       
      Pheochromocytoma Benign                          4 (8%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
   Thyroid Gland                                      (48)         (47)         (48)                                                
      Follicular Cell, Adenoma                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)                                                
   Preputial Gland                                    (9)          (2)          (4)                                                 
      Hemangiosarcoma                                  1 (11%)                                                                      
   Testes                                             (49)         (49)         (50)                                                
      Interstitial Cell, Adenoma, Multiple             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (50)         (49)         (49)                                                
      Bronchial, Mediastinal, Fibrosarcoma,                                                                                         
          Metastatic, Stomach                          1 (2%)                                                                       
   Lymph Node, Mandibular                             (45)         (41)         (46)                                                
      Bronchial, Mediastinal, Alveolar/Bronchiolar                                                                                  
          Carcinoma, Metastatic, Lung                                            1 (2%)                                             
   Lymph Node, Mesenteric                             (47)         (46)         (44)                                                
   Spleen                                             (50)         (49)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (44)         (43)         (41)                                                
      Mediastinum, Fibrosarcoma, Metastatic, Skin                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Melanoma Benign                                               1 (2%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)       3 (6%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)                                                          
                                                             Page   8                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibrosarcoma                7 (14%)      5 (10%)     11 (22%)                                            
      Subcutaneous Tissue, Fibrosarcoma, Multiple      2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        2 (4%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant,                                                                                    
           Multiple                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (1)                                                 
      Fibrosarcoma, Metastatic, Stomach                1 (100%)                                                                     
      Diaphragm, Intercostal, Alveolar/Bronchiolar                                                                                  
          Carcinoma, Metastatic, Lung                                            1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     5 (10%)      2 (4%)       4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Fibrosarcoma, Metastatic, Stomach                1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (3)          (2)                                                 
      Adenoma                                          2 (100%)     3 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Stomach                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia                                         1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                                2 (4%)       1 (2%)                                             
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Lymphocytic                   5 (10%)      1 (2%)       1 (2%)                                             
      Lymphoma Malignant Mixed                                                   4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05051-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 14:37:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            31          27          33                                                   
     Total Primary Neoplasms                           53          35          42                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 12          11          14                                                   
     Total Benign Neoplasms                            17          15          14                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          20          24                                                   
     Total Malignant Neoplasms                         36          20          28                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           3                                                   
     Total Metastatic Neoplasm                          5           2           6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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