National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2097

TR 349 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 TECHNICAL GRADE PENTACHLOROPHENOL


NTP Experiment-Test: 05073-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 05:28:03




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          35           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      6            8           13                                                  
    Moribund Sacrifice                                              1            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           41           30                                                  
    Natural Death                                      1                         2                                                  
  Animals Examined Microscopically                    35           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (32)         (3)          (47)                                                
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Small, Duodenum                          (32)         (3)          (47)                                                
      Mineralization                                                             1 (2%)                                             
   Liver                                              (33)         (49)         (50)                                                
      Basophilic Focus                                 1 (3%)                    5 (10%)                                            
      Clear Cell Focus                                 1 (3%)       3 (6%)       7 (14%)                                            
      Clear Cell Focus, Multiple                                                10 (20%)                                            
      Degeneration, Cystic                             1 (3%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal    14 (42%)      8 (16%)     33 (66%)                                            
      Hyperplasia                                                                3 (6%)                                             
      Infarct                                          4 (12%)      2 (4%)       2 (4%)                                             
      Inflammation, Chronic Active, Diffuse                        34 (69%)     44 (88%)                                            
      Pigmentation, Multifocal                                     37 (76%)     47 (94%)                                            
      Vacuolization Cytoplasmic                        1 (3%)       3 (6%)                                                          
      Bile Duct, Hyperplasia, Multifocal                            1 (2%)       2 (4%)                                             
      Bile Duct, Inflammation, Chronic Active,                                                                                      
           Multifocal                                               1 (2%)                                                          
      Hepatocyte, Cytomegaly, Diffuse                              48 (98%)     48 (96%)                                            
      Hepatocyte, Necrosis, Acute, Diffuse                         44 (90%)     47 (94%)                                            
   Mesentery                                          (3)          (1)                                                              
      Inflammation, Chronic                            1 (33%)                                                                      
   Pancreas                                           (31)         (4)          (48)                                                
      Acinus, Atrophy                                  4 (13%)                   6 (13%)                                            
      Acinus, Inflammation, Chronic                                              1 (2%)                                             
      Duct, Cyst                                                                 2 (4%)                                             
   Salivary Glands                                    (33)         (4)          (47)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Stomach, Forestomach                               (32)         (3)          (46)                                                
      Acanthosis                                       4 (13%)                   3 (7%)                                             
      Erosion                                                                    1 (2%)                                             
      Inflammation, Chronic Active                     3 (9%)                    1 (2%)                                             
      Ulcer, Acute                                     2 (6%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (32)         (3)          (47)                                                
      Dysplasia                                        1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (35)         (4)          (50)                                                
      Mineralization                                                             1 (2%)                                             
      Perivascular, Inflammation, Chronic Active                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (34)         (48)         (49)                                                
      Capsule, Hyperplasia                            33 (97%)     48 (100%)    49 (100%)                                           
   Adrenal Gland, Cortex                              (33)         (48)         (49)                                                
      Atrophy                                                       1 (2%)                                                          
      Degeneration, Fatty                                           1 (2%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)       2 (4%)                                             
      Hyperplasia                                      1 (3%)       2 (4%)       3 (6%)                                             
      Hypertrophy                                      1 (3%)       2 (4%)       4 (8%)                                             
   Adrenal Gland, Medulla                             (33)         (48)         (49)                                                
      Hyperplasia                                                   4 (8%)       2 (4%)                                             
   Parathyroid Gland                                  (30)         (4)          (35)                                                
      Infiltration Cellular, Lymphocyte                1 (3%)                                                                       
   Pituitary Gland                                    (32)         (14)         (39)                                                
      Pars Distalis, Cyst                              1 (3%)       1 (7%)                                                          
      Pars Distalis, Hyperplasia                      10 (31%)      4 (29%)     10 (26%)                                            
   Thyroid Gland                                      (33)         (4)          (48)                                                
      Inflammation, Chronic                            3 (9%)                                                                       
      Follicular Cell, Hyperplasia                     7 (21%)                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (30)         (23)         (48)                                                
      Angiectasis                                                                1 (2%)                                             
      Inflammation, Chronic Active                                  1 (4%)       1 (2%)                                             
      Mineralization                                                1 (4%)                                                          
      Follicle, Cyst                                   8 (27%)      9 (39%)     15 (31%)                                            
      Periovarian Tissue, Cyst                         2 (7%)      10 (43%)      3 (6%)                                             
   Uterus                                             (33)         (37)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     1 (3%)                                                                       
      Endometrium, Hyperplasia, Cystic, Glandular,                                                                                  
           Multifocal                                 28 (85%)     35 (95%)     35 (73%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                        (2)                                                 
      Leukocytosis                                                               1 (50%)                                            
      Neutrophilia                                                               1 (50%)                                            
   Bone Marrow                                        (35)         (4)          (49)                                                
      Femoral, Hyperplasia, Neutrophil                                           2 (4%)                                             
      Femoral, Myelofibrosis                           8 (23%)      1 (25%)     15 (31%)                                            
      Sternal, Myelofibrosis                                                     2 (4%)                                             
   Lymph Node                                         (33)         (12)         (46)                                                
      Mesenteric, Hematopoietic Cell Proliferation     1 (3%)       3 (25%)      2 (4%)                                             
      Mesenteric, Hemorrhage                                                     1 (2%)                                             
   Lymph Node, Mandibular                             (33)         (4)          (45)                                                
      Angiectasis                                                                1 (2%)                                             
      Depletion Lymphoid                               1 (3%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                                      3 (7%)                                             
   Spleen                                             (33)         (13)         (47)                                                
      Atrophy                                                                    1 (2%)                                             
      Depletion Lymphoid                               2 (6%)       1 (8%)                                                          
      Hematocyst                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     2 (6%)       4 (31%)     11 (23%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (30)         (3)          (34)                                                
      Hyperplasia, Cystic                              7 (23%)                  20 (59%)                                            
   Skin                                               (33)         (5)          (48)                                                
      Acanthosis                                       1 (3%)                                                                       
      Ulcer                                            1 (3%)                    1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (33)         (4)          (49)                                                
      Compression                                                                2 (4%)                                             
      Meninges, Infiltration Cellular, Lymphocyte      2 (6%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (35)         (5)          (50)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                           2 (4%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                             1 (2%)                                             
   Nose                                               (35)         (4)          (49)                                                
      Lumen, Foreign Body                              1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (32)         (4)          (49)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (33)         (7)          (49)                                                
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Inflammation, Chronic Active, Multifocal                      1 (14%)                                                         
      Metaplasia, Osseous                                                        2 (4%)                                             
      Nephropathy, Chronic                            13 (39%)                  13 (27%)                                            
      Glomerulus, Amyloid Deposition                   1 (3%)                                                                       
      Renal Tubule, Cytoplasmic Alteration, Diffuse                 1 (14%)      1 (2%)                                             
      Renal Tubule, Necrosis, Acute                                              1 (2%)                                             
   Urinary Bladder                                    (32)         (3)          (47)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          35           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     18           14           21                                                  
    Moribund Sacrifice                                 5           12            3                                                  
    Drowned                                                                      4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           24           22                                                  
  Animals Examined Microscopically                    35           49           49                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (27)         (15)         (41)                                                
      Parasite Metazoan                                1 (4%)       1 (7%)       1 (2%)                                             
   Intestine Small, Duodenum                          (24)         (12)         (38)                                                
      Ulcer                                            1 (4%)                                                                       
   Liver                                              (32)         (47)         (48)                                                
      Angiectasis                                                   1 (2%)       2 (4%)                                             
      Basophilic Focus                                 2 (6%)       1 (2%)       4 (8%)                                             
      Clear Cell Focus                                              4 (9%)       6 (13%)                                            
      Clear Cell Focus, Multiple                                    7 (15%)                                                         
      Fibrosis                                         1 (3%)                                                                       
      Hematopoietic Cell Proliferation, Multifocal     2 (6%)      20 (43%)     27 (56%)                                            
      Hyperplasia                                                   6 (13%)      5 (10%)                                            
      Infarct                                          1 (3%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active, Diffuse                        42 (89%)     46 (96%)                                            
      Pigmentation, Multifocal                                     45 (96%)     46 (96%)                                            
      Vacuolization Cytoplasmic                                     2 (4%)                                                          
      Bile Duct, Cyst, Multiple                                                  1 (2%)                                             
      Bile Duct, Dilatation, Focal                                               1 (2%)                                             
      Bile Duct, Hyperplasia, Multifocal                           22 (47%)     37 (77%)                                            
      Hepatocyte, Cytomegaly, Diffuse                              47 (100%)    48 (100%)                                           
      Hepatocyte, Necrosis, Acute, Diffuse                         41 (87%)     45 (94%)                                            
   Mesentery                                          (2)                       (2)                                                 
      Inflammation, Chronic                            1 (50%)                   1 (50%)                                            
   Salivary Glands                                    (32)         (15)         (48)                                                
      Inflammation, Acute                              1 (3%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
   Stomach, Forestomach                               (31)         (14)         (43)                                                
      Acanthosis                                                                 2 (5%)                                             
      Cyst                                             1 (3%)                                                                       
      Inflammation, Chronic Active                                               2 (5%)                                             
      Ulcer, Chronic Active                                                      1 (2%)                                             
   Stomach, Glandular                                 (31)         (14)         (42)                                                
      Hyperplasia                                      1 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis                                         1 (3%)                                                                       
      Ulcer, Acute                                                               1 (2%)                                             
   Tooth                                              (1)                       (3)                                                 
      Peridontal Tissue, Inflammation, Chronic                                   3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (33)         (18)         (49)                                                
      Degeneration, Chronic                            2 (6%)       1 (6%)       2 (4%)                                             
      Mineralization                                                1 (6%)       1 (2%)                                             
      Atrium, Thrombosis                                            2 (11%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (31)         (47)         (46)                                                
      Capsule, Hyperplasia                            27 (87%)     33 (70%)     27 (59%)                                            
   Adrenal Gland, Cortex                              (31)         (46)         (46)                                                
      Degeneration, Fatty                                           2 (4%)                                                          
      Hyperplasia                                                                4 (9%)                                             
      Hypertrophy                                      5 (16%)     10 (22%)      6 (13%)                                            
   Adrenal Gland, Medulla                             (31)         (45)         (45)                                                
      Hyperplasia                                      1 (3%)      10 (22%)     10 (22%)                                            
   Pituitary Gland                                    (29)         (12)         (41)                                                
      Pars Distalis, Cyst                              1 (3%)       1 (8%)                                                          
   Thyroid Gland                                      (31)         (15)         (47)                                                
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                     3 (10%)                                                                      
      Follicular Cell, Hypertrophy                     1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Inflammation, Focal, Granulomatous                                         1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (34)         (17)         (47)                                                
      Granuloma Sperm                                               1 (6%)                                                          
      Inflammation, Acute                              1 (3%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
   Penis                                              (2)          (5)                                                              
      Inflammation, Acute                                           1 (20%)                                                         
      Inflammation, Chronic Active                                  1 (20%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Preputial Gland                                    (6)          (6)          (8)                                                 
      Inflammation, Acute                                                        6 (75%)                                            
      Inflammation, Chronic Active                     3 (50%)      4 (67%)                                                         
      Duct, Dilatation                                 2 (33%)                   1 (13%)                                            
   Prostate                                           (34)         (15)         (45)                                                
      Inflammation, Acute                              6 (18%)      1 (7%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (9%)       4 (27%)      3 (7%)                                             
   Seminal Vesicle                                    (7)          (4)          (7)                                                 
      Dilatation                                       5 (71%)      3 (75%)      6 (86%)                                            
      Inflammation, Acute                                                        1 (14%)                                            
      Inflammation, Chronic Active                     2 (29%)      1 (25%)      1 (14%)                                            
   Testes                                             (34)         (17)         (47)                                                
      Inflammation, Acute                              1 (3%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Germinal Epithelium, Degeneration                1 (3%)       3 (18%)      3 (6%)                                             
      Germinal Epithelium, Mineralization                                        2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (1)                                                              
      Neutrophilia                                     1 (50%)      1 (100%)                                                        
   Bone Marrow                                        (30)         (15)         (44)                                                
      Femoral, Hyperplasia, Neutrophil                 2 (7%)       2 (13%)      3 (7%)                                             
   Lymph Node                                         (27)         (24)         (44)                                                
      Inguinal, Infiltration Cellular, Plasma Cell                               1 (2%)                                             
      Lumbar, Hyperplasia, Plasma Cell                              1 (4%)                                                          
      Mesenteric, Hematopoietic Cell Proliferation     5 (19%)     10 (42%)     10 (23%)                                            
      Mesenteric, Hyperplasia, Lymphoid                                          1 (2%)                                             
      Renal, Hyperplasia, Plasma Cell                  1 (4%)                                                                       
   Lymph Node, Mandibular                             (27)         (12)         (43)                                                
      Depletion Lymphoid                               1 (4%)                    2 (5%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Lymphoid                                                      4 (9%)                                             
      Hyperplasia, Plasma Cell                         1 (4%)                                                                       
   Spleen                                             (30)         (23)         (46)                                                
      Depletion Lymphoid                               8 (27%)      3 (13%)     10 (22%)                                            
      Lymphoid Follicle, Necrosis                      2 (7%)                                                                       
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     5 (17%)     15 (65%)     18 (39%)                                            
   Thymus                                             (16)         (7)          (18)                                                
      Necrosis                                         1 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (33)         (27)         (49)                                                
      Acanthosis                                       1 (3%)       1 (4%)                                                          
      Alopecia                                                      2 (7%)                                                          
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Foreign Body, Focal                                                        1 (2%)                                             
      Hyperkeratosis                                                1 (4%)                                                          
      Ulcer                                            3 (9%)       5 (19%)      6 (12%)                                            
      Subcutaneous Tissue, Fibrosis                                 4 (15%)                                                         
      Subcutaneous Tissue, Inflammation, Acute         1 (3%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       5 (15%)                   6 (12%)                                            
      Subcutaneous Tissue, Metaplasia, Osseous         1 (3%)                                                                       
      Subcutaneous Tissue, Lymphatic, Dilatation       1 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (35)         (28)         (48)                                                
      Joint, Femur, Tibia, Hyperostosis                             1 (4%)       3 (6%)                                             
      Joint, Tarsal, Hyperostosis                     11 (31%)     13 (46%)      9 (19%)                                            
   Skeletal Muscle                                                 (1)                                                              
      Mineralization, Multifocal                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (33)         (18)         (49)                                                
      Hemorrhage, Acute                                                          1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                           2 (4%)                                             
      Alveolus, Foreign Body                                                     4 (8%)                                             
      Interstitium, Inflammation, Acute                             1 (6%)                                                          
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                                            1 (2%)                                             
      Interstitium, Mineralization                                  1 (6%)                                                          
      Perivascular, Edema, Acute                                                 4 (8%)                                             
      Perivascular, Edema, Chronic Active                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05073-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)                                                 
      Atrophy, Diffuse                                 1 (50%)                   1 (100%)                                           
      Lens, Cataract                                   1 (50%)                                                                      
      Retina, Atrophy                                  1 (50%)                                                                      
   Harderian Gland                                    (29)         (12)         (43)                                                
      Hyperplasia, Cystic                              1 (3%)                                                                       
      Acinus, Dilatation                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (33)         (18)         (47)                                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Inflammation, Acute                              2 (6%)       1 (6%)       4 (9%)                                             
      Inflammation, Chronic Active                     1 (3%)       2 (11%)      1 (2%)                                             
      Metaplasia, Osseous                              1 (3%)                                                                       
      Nephropathy, Chronic                            11 (33%)      3 (17%)     22 (47%)                                            
      Cortex, Cyst                                                               1 (2%)                                             
      Pelvis, Inflammation, Acute                      1 (3%)       3 (17%)                                                         
      Pelvis, Inflammation, Chronic Active             1 (3%)                                                                       
      Renal Tubule, Dilatation                         2 (6%)                                                                       
      Renal Tubule, Mineralization                                  1 (6%)       1 (2%)                                             
      Renal Tubule, Necrosis                           1 (3%)                                                                       
   Urethra                                            (6)          (2)                                                              
      Calculus Micro Observation Only                  2 (33%)      1 (50%)                                                         
      Concretion                                       2 (33%)                                                                      
      Inflammation, Acute                              2 (33%)      1 (50%)                                                         
      Inflammation, Chronic Active                     1 (17%)                                                                      
   Urinary Bladder                                    (34)         (15)         (43)                                                
      Calculus Gross Observation                                                 1 (2%)                                             
      Calculus Micro Observation Only                  1 (3%)                                                                       
      Concretion                                       1 (3%)                                                                       
      Dilatation                                       6 (18%)      3 (20%)      2 (5%)                                             
      Inflammation, Acute                              5 (15%)      1 (7%)                                                          
      Inflammation, Chronic Active                     1 (3%)       2 (13%)      2 (5%)                                             
      Necrosis                                         1 (3%)                                                                       
      Mucosa, Hyperplasia                                           1 (7%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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