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TR 351 Mouse Pathology Tables

NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 14:10:51




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-47-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Parasite Metazoan                    | X                                X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Ulcer, Chronic, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                         2                                                |             
      Basophilic Focus                     |                                        X                                 |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    2  2     2     2     2  2     1        2           2                  |             
      Necrosis, Acute, Multifocal          |                                                             2            |             
      Hepatocyte, Karyomegaly, Focal       |                                                                         2|             
      Periportal, Inflammation, Multifocal |                                              2                           |             
      Sinusoid, Infiltration Cellular,     |                                                                          |             
           Diffuse, Polymorphonuclear      |          3                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               |                         2                                                |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
      Duct, Cyst, Multiple                 |                                                                          |             
      Duct, Inflammation, Chronic,         |                                                                          |             
          Multifocal                       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Necrosis, Acute, Focal               |                                                                   2      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Cyst                        |                                                                          |             
      Capsule, Hyperplasia, Cystic,        |                                                                          |             
          Glandular, Multifocal            |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 3  3  2  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                 X                        |             
      Hyperplasia, Focal                   |                                              2                           |             
      Hyperplasia, Multifocal              |                                                                          |             
      Hypertrophy, Focal                   |    2                                                                     |             
      Hypertrophy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  +  +  M  +  M  +  M  +  +  M  +  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Cyst                  |             X                                   X                        |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                         2                                2               |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Necrosis, Acute, Focal               |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Thrombosis, Chronic Active           |                                                                          |             
      Follicle, Cyst                       |                      X        X        X     X  X           X        X   |             
      Follicle, Cyst, Multiple             |                                                                          |             
      Periovarian Tissue, Cyst             |                X                       X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Angiectasis, Multifocal |                   3                                                      |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |    3  2  3  3  2  3  3  4  2  3  3  3  2  3  3  3  3  4  4  2     4  3  3|             
      Myometrium, Angiectasis, Multifocal  |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Angiectasis, Focal          |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Myelofibrosis, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  +  M  M|             
      Lymphatic, Ectasia, Focal            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 1  1  2  3  1  1  1  1  2  1  2  2  1  1  2  2  1  1  1  2  3  3  3  1  1|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      | 2  1  2  1  1  2  2  1  1        1  1  1     1  2  1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Medulla, Thymocyte, Hyperplasia,     |                                                                          |             
           Diffuse                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite External                    |                                     X  X  X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Joint, Tarsal,            |                                                                          |             
          Hyperostosis                     |       2                                                                  |             
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |             
           Multifocal, Osseous             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                             2            |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                     2  2                                 |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Mediastinum, Foreign Body, Multifocal|                                                                          |             
      Perivascular, Hyperplasia, Lymphoid, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 2| 2| 3| 2| 3| 2| 2| 2| 3| 2| 6| 8| 1| 3| 2|             
                                           | 3| 8| 8| 7| 9| 1| 0| 9| 8| 0| 8| 8| 2| 8| 1| 9| 8| 8| 0| 9| 6| 0| 7| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Multifocal                      |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active, Diffuse|          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic, Diffuse        |                                                                          |             
      Nephropathy, Chronic, Focal          | 3                                2  2                                    |             
      Nephropathy, Chronic, Multifocal     |                                                                          |             
      Glomerulus, Amyloid Deposition,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Regeneration, Focal    |                                                                          |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |    2           2           2                          2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Inflammation, Chronic, Focal         |                                  3                                       |      1  3.0|
      Ulcer, Chronic, Focal                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                              X                           |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |          2     2     2                             2        2        2   |     15  1.9|
      Necrosis, Acute, Multifocal          |                                                                          |      1  2.0|
      Hepatocyte, Karyomegaly, Focal       |                                                                          |      1  2.0|
      Periportal, Inflammation, Multifocal |                                                                          |      1  2.0|
      Sinusoid, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Polymorphonuclear      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy, Diffuse             |                            4                                             |      1  4.0|
      Acinus, Atrophy, Focal               |                                                                          |      1  2.0|
      Acinus, Atrophy, Multifocal          |                                     4                                    |      1  4.0|
      Duct, Cyst, Multiple                 |                            X                                             |      1     |
      Duct, Inflammation, Chronic,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Necrosis, Acute, Focal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Cyst                        |                                        X                                 |      1     |
      Capsule, Hyperplasia, Cystic,        |                                                                          |            |
          Glandular, Multifocal            |          3                                                               |      1  3.0|
      Capsule, Hyperplasia, Multifocal     | 3  2  3        3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3|     48  2.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                               2                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                         2|      2  2.0|
      Hypertrophy, Multifocal              |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Cyst                  |                            X                                             |      3     |
      Pars Distalis, Cyst, Multiple        |                X                                                         |      1     |
      Pars Distalis, Hyperplasia, Focal    |                   2        3                       2                     |      5  2.2|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis, Acute, Focal               |             2                                                            |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |                            3                                             |      1  3.0|
      Thrombosis, Chronic Active           |                X                                                         |      1     |
      Follicle, Cyst                       |    X              X                    X                                 |     10     |
      Follicle, Cyst, Multiple             |                X                                   X  X                  |      3     |
      Periovarian Tissue, Cyst             |                                              X                           |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Angiectasis, Multifocal |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 2  2  4  3     4     4  3  4  3  2  2  3  2  3  1  3  3     3  3  3  4  2|     45  2.9|
      Myometrium, Angiectasis, Multifocal  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Femoral, Angiectasis, Focal          |                                                                          |      1  3.0|
      Femoral, Myelofibrosis, Multifocal   |                               2                    2  3                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  M  M  M  M  +  M  +  M  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M|   8        |
      Lymphatic, Ectasia, Focal            |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |            |
           Multifocal                      |             3                                                            |      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           | 1     1  1  2  1  3  1  1  1  1     2  1  1  1  1  1  1  1  1  1  1  1  1|     48  1.4|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      | 1  1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|     45  1.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  M  +|  41        |
      Necrosis, Acute, Multifocal          |             3                                                            |      1  3.0|
      Medulla, Thymocyte, Hyperplasia,     |                                                                          |            |
           Diffuse                         |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  +  +  +  M  +  M  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite External                    |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Joint, Tarsal,            |                                                                          |            |
          Hyperostosis                     |                                                                          |      1  2.0|
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |            |
           Multifocal, Osseous             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 0| 3| 2| 3| 7| 3| 2| 9| 9| 2| 3| 3| 2| 3| 2| 4| 2| 3| 2| 3| 2|            |
                                           | 0| 4| 2| 2| 1| 1| 9| 0| 2| 0| 8| 5| 5| 8| 0| 0| 8| 1| 8| 3| 9| 2| 8| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Lymphocyte          |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |          2                                                               |      1  2.0|
      Mediastinum, Foreign Body, Multifocal|             4                                                            |      1  4.0|
      Perivascular, Hyperplasia, Lymphoid, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active, Diffuse|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic, Diffuse        |                                                          4               |      1  4.0|
      Nephropathy, Chronic, Focal          |                                                                          |      3  2.3|
      Nephropathy, Chronic, Multifocal     |                2                                                         |      1  2.0|
      Glomerulus, Amyloid Deposition,      |                                                                          |            |
          Multifocal                       |                                                          4               |      1  4.0|
      Renal Tubule, Regeneration, Focal    |                                        1  2                       2      |      3  1.7|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|             
                                           | 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +     +                 M                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +     +                 M                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +     +                 A                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                         X|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2  3        1           1  1  1           2  2  3  2  1  2  2  2     2  1|             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Karyomegaly, Focal       |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                   +                                 |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |    4                                   4                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +     +                 +     +                                 |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                        3                                 |             
      Acinus, Atrophy, Multifocal          |                                        3                                 |             
      Duct, Cyst                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +     +                 +                                       |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Multifocal                      |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +     +                 +                                       |             
      Capsule, Hyperplasia, Multifocal     |       3                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M     M                 M                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +     +                 M                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|             
                                           | 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +     M                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +           +     +                    +        +         |             
      Thrombosis, Chronic Active           |                                                                          |             
      Follicle, Cyst                       |                            X                          X        X         |             
      Periovarian Tissue, Cyst             | X                                                                        |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic Active, Multifocal      |    4                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +        +|             
      Inflammation, Chronic, Multifocal,   |                                                                          |             
           Suppurative                     |                                        4                                 |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 3     2           3  4        3     3  3  3  3  3  3  2  3  4  4        3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       M  M     M                 M                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |             
           Multifocal                      |                2                 2                                       |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 2  4  4  2  2  2  2  2  2  3  2  2  2  4  2  2  2  2  2  2  2  2  2  2  2|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      | 2  2        2  2  1  2  2  2  2     3  2  2  3  2  2  3  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  |       M  +     +                 +                                       |             
      Necrosis, Acute, Multifocal          |          3     3                 4                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  M     +              +  M                                      +|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +     +              +  +                                      +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 0| 7| 0| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 1| 2| 0| 3| 0| 3| 2| 3| 3| 3| 0| 3| 8| 2| 3| 3| 3| 0| 2| 3| 2| 3| 2| 2|             
                                           | 9| 4| 8| 1| 1| 1| 1| 8| 1| 2| 1| 2| 1| 2| 9| 0| 1| 2| 9| 9| 0| 8| 2| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +     +           +     +                                   +   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                      2   |             
      Mediastinum, Foreign Body, Multifocal|          3     3                 4                                       |             
      Pleura, Inflammation, Acute, Diffuse |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cornea, Inflammation, Chronic Active,|                                                                          |             
           Diffuse, Necrotizing            |                      4                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +     M     +           M                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +     +                 +                       +               |             
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |             
           Diffuse                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3|            |
                                           | 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                          A               |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                          +               |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                  X                                       |      2     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2     2     2  1           1  2  2     2        2        2  2        2  2|     29  1.8|
      Necrosis, Acute, Multifocal          | 2                                                                        |      1  2.0|
      Bile Duct, Cyst                      |                                           X                              |      1     |
      Hepatocyte, Karyomegaly, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                  +                       +               |   7        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Acinus, Atrophy, Multifocal          |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                          +               |   5        |
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                          +               |   5        |
      Capsule, Hyperplasia, Multifocal     |                                                          3               |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3|            |
                                           | 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          M        +                                      +               |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                          +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +                 +                       +     +  +      |  14        |
      Thrombosis, Chronic Active           |                                                                X         |      1     |
      Follicle, Cyst                       |                X                 X                             X  X      |      7     |
      Periovarian Tissue, Cyst             |                                                                          |      1     |
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic Active, Multifocal      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +     +  +  +  +     +  +  +  +  +     +  +  +  +     +  +|  38        |
      Inflammation, Chronic, Multifocal,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 3  3  3        2     3  3  3  3     3  3  2  3  2     3  2  3  3     3  2|     35  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                          M               |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           | 2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  3  3  2  2|     50  2.2|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      | 2  3  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2|     47  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                          +               |   4        |
      Necrosis, Acute, Multifocal          |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 3| 2| 2| 3| 3| 3| 3| 2| 3| 2| 2| 3| 2| 2| 3| 3| 3| 2| 2| 3|            |
                                           | 8| 0| 2| 1| 9| 2| 8| 8| 1| 1| 2| 2| 9| 2| 9| 9| 2| 9| 9| 9| 1| 2| 8| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                          +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                          +        +      |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                          +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                  +                       +               |   8        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Mediastinum, Foreign Body, Multifocal|                                                                          |      3  3.3|
      Pleura, Inflammation, Acute, Diffuse |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                          +               |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                          +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic Active,|                                                                          |            |
           Diffuse, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                          +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +                                         +               |   7        |
      Renal Tubule, Cytoplasmic Alteration,|                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                          +               |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             2                                                            |             
      Lumen, Pigmentation, Diffuse         |                                  3                                       |             
      Mucosa, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Necrosis, Acute, Diffuse             |                                  4                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X                                                   |             
      Cytomegaly, Focal                    |                                        3                                 |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2     2     2  2     2     2  2  2        2  2  2  3        1  2  2  2  2|             
      Necrosis, Acute, Multifocal          |                                                          3               |             
      Thrombosis, Chronic                  |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                       3                  |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Multifocal                       |                                                                          |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2           2  2  2  2  2|             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal, Suppurative          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Inflammation, Chronic, Multifocal,   |                                                                          |             
           Suppurative                     |                                                    3                     |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal,   |                                                                          |             
           Suppurative                     |                                                    3                     |             
      Acinus, Atrophy, Focal               |                                        2                                 |             
      Acinus, Atrophy, Multifocal          |          2                 2                                             |             
      Duct, Cyst                           |                                                                          |             
      Duct, Ectasia, Focal                 |                                           3                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             3              2                 2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy, Focal               |                                                 3                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                             2            |             
      Hyperkeratosis, Focal                |                                                             2            |             
      Ulcer, Acute, Focal                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active, Multifocal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  2  3  2  3  3  3  3  3|             
      Corticomedullary Junction,           |                                                                          |             
          Degeneration, Fatty, Multifocal  |                                              2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |                                                 2                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                  2                                       |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal, Plasma |                                                                          |             
          Cell                             |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +  +  I|             
      Pars Distalis, Cyst                  |          X                                                               |             
      Pars Distalis, Hyperplasia, Focal    |          2  2                       2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia, Focal  |                      2                                                   |             
      Follicular Cell, Hyperplasia         |                                              3                           |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multifocal                       |                                                 2                        |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Inflammation, Chronic, Multifocal,   |                                                                          |             
           Suppurative                     |                                                    4                     |             
      Corpus Luteum, Angiectasis,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Follicle, Cyst                       |       X           X     X        X  X  X        X                        |             
      Follicle, Cyst, Multiple             |             X                                                            |             
      Periovarian Tissue, Cyst             |                                                                          |             
      Periovarian Tissue, Infiltration     |                                                                          |             
          Cellular, Multifocal, Lymphocyte |          3                                                               |             
      Rete Ovarii, Cyst                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal,   |                                                                          |             
           Suppurative                     |                                                    3                     |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 3  2  3     3  3  3  3  2     3  2  3  3  3  3  2  2  3     3  4  3  4  3|             
      Mucosa, Metaplasia, Multifocal,      |                                                                          |             
          Squamous                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                       +                                       |             
      Neutrophilia                         |          X                       X                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |          3                       3                                       |             
      Femoral, Myelofibrosis, Multifocal   |                               2     1                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Diffuse,   |                                                                          |             
           Lymphoid                        |                                                    4                     |             
      Renal, Hyperplasia, Diffuse, Lymphoid|                                                    4                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse, Lymphoid       |                                                    4                     |             
      Hyperplasia, Multifocal, Plasma Cell |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Multifocal     |                                                       2                  |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 2  1  2  3  2  2  2  3  1  3  2  4  2  2  2  2  3  4  2     2  2  2  2  2|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      | 2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +  M  M|             
      Depletion Lymphoid, Multifocal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Cranium, Hyperostosis, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Compression, Focal     |                                              3                           |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Multifocal, Lymphocyte          |                                                                2         |             
      Meninges, Inflammation, Chronic      |                                                                          |             
          Active, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                 2                        |             
      Alveolus, Hemorrhage, Multifocal     |                                                          3               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Focal                    |                                                                          |             
      Perivascular, Inflammation, Chronic, |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              I     +                     |             
      Degeneration, Diffuse                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Acinus, Hyperplasia, Multifocal      |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |                                                                          |             
      Nephropathy, Chronic, Focal          |                                                                          |             
      Nephropathy, Chronic, Multifocal     |                                                                          |             
      Glomerulus, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                    2                     |             
      Perivascular, Infiltration Cellular, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 3| 3| 3| 3| 6| 2| 0| 2| 2| 3| 2| 3| 5| 3| 0| 2| 3| 2| 2| 3|             
                                           | 1| 9| 8| 8| 1| 2| 2| 2| 0| 7| 9| 4| 9| 8| 2| 8| 1| 0| 2| 9| 9| 2| 8| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Multifocal, Plasma Cell         |          2                                                               |             
      Renal Tubule, Dilatation, Diffuse    |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin, Multifocal          | 2  2  1     1  2  1     1  1  2     1  1  1  2  1     1  1  1  1  1  1  1|             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Lumen, Pigmentation, Diffuse         |                                                                          |      1  3.0|
      Mucosa, Cyst                         |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Necrosis, Acute, Diffuse             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Cytomegaly, Focal                    |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    2        2     3  3  2  2     2     2     2     2        2  2  2     2|     31  2.1|
      Necrosis, Acute, Multifocal          |                                                                          |      1  3.0|
      Thrombosis, Chronic                  |       X                                                                  |      1     |
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  3.0|
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Multifocal                       |          3                                                               |      1  3.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     46  2.0|
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal, Suppurative          |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                       +                                          |   3        |
      Inflammation, Chronic, Multifocal,   |                                                                          |            |
           Suppurative                     |       3                                                                  |      2  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic, Multifocal,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Acinus, Atrophy, Focal               |             2                                                            |      2  2.0|
      Acinus, Atrophy, Multifocal          |                                                    4     2        3      |      5  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Cyst                           |                                                    X                     |      1     |
      Duct, Ectasia, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      3  2.3|
      Acinus, Atrophy, Focal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Acanthosis, Focal                    |                                                                          |      1  2.0|
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|
      Ulcer, Acute, Focal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active, Multifocal       |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia, Focal          |                                                 3                        |      1  3.0|
      Capsule, Hyperplasia, Multifocal     | 3  2  2  2  3  3  3  3  3  3  3  2  3  3     3     3  3  3  3  3  3  3  3|     48  2.9|
      Corticomedullary Junction,           |                                                                          |            |
          Degeneration, Fatty, Multifocal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty, Focal           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                        2                                 |      1  2.0|
      Hypertrophy, Focal                   |                      2     3                                             |      2  2.5|
      Hypertrophy, Multifocal              |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Focal, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  42        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                  1                 2              2      |      6  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  M  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis, Focal                   |                            2                                             |      1  2.0|
      Inflammation, Chronic, Multifocal,   |                                                                          |            |
           Suppurative                     |       4                                                                  |      2  4.0|
      Corpus Luteum, Angiectasis,          |                                                                          |            |
          Multifocal                       |             3                                                            |      1  3.0|
      Follicle, Cyst                       | X  X     X     X              X                       X        X         |     14     |
      Follicle, Cyst, Multiple             |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                                                 X                        |      1     |
      Periovarian Tissue, Infiltration     |                                                                          |            |
          Cellular, Multifocal, Lymphocyte |                                                                          |      1  3.0|
      Rete Ovarii, Cyst                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Multifocal,   |                                                                          |            |
           Suppurative                     |       4                                                                  |      2  3.5|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 2  2     1  2  2  3  2  3     3  2  3  4        3  2  3  4  3  3  2  3  4|     43  2.8|
      Mucosa, Metaplasia, Multifocal,      |                                                                          |            |
          Squamous                         |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                      +                                                   |   3        |
      Neutrophilia                         |                      X                                                   |      3     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hyperplasia, Diffuse,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Neutrophil                       |                                                                          |      2  3.0|
      Femoral, Myelofibrosis, Multifocal   | 2                       2                                                |      4  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Mediastinal, Hyperplasia, Diffuse,   |                                                                          |            |
           Lymphoid                        |       3                                                                  |      2  3.5|
      Renal, Hyperplasia, Diffuse, Lymphoid|                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |      1  4.0|
      Hyperplasia, Multifocal, Plasma Cell |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  M  M  M  M  M  M  M  M  +  M  M  M  A  M  M  M  M  M  M  M  M  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia, Multifocal     |                                                                          |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           | 2  3  4  3  2  2  2  3  2  3  1  2  2  2     2  3  2  2  2  2  2  3  2  2|     48  2.3|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      | 2  2  2  2  2  2  2  2  2  2  1  2  3  2     2  2  2  2  2  2  2  2  2  2|     49  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +|  35        |
      Depletion Lymphoid, Multifocal       |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  M  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Fibrous Osteodystrophy      |                                        X                                 |      1     |
      Cranium, Hyperostosis, Focal         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hypothalamus, Compression, Focal     |                                                                          |      1  3.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Multifocal, Lymphocyte          |             2                                                            |      2  2.0|
      Meninges, Inflammation, Chronic      |                                                                          |            |
          Active, Multifocal               |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 5| 1| 2| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 1| 2| 8| 6| 9| 2| 1| 0| 0| 1| 1| 0| 9| 2| 7| 2| 0| 8| 1| 1| 0| 2| 1| 2| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                         2                             2                  |      3  2.0|
      Alveolus, Hemorrhage, Multifocal     |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Focal                    |                                                    2                     |      1  2.0|
      Perivascular, Inflammation, Chronic, |                                                                          |            |
           Multifocal                      |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration, Diffuse                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acinus, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization, Multifocal           |                                                                   2      |      1  2.0|
      Nephropathy, Chronic, Focal          |                                                          2               |      1  2.0|
      Nephropathy, Chronic, Multifocal     |                                                                2         |      1  2.0|
      Glomerulus, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |       2              2                                                   |      3  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Plasma Cell         |                                                                          |      1  2.0|
      Renal Tubule, Dilatation, Diffuse    |                                                                   3      |      1  3.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin, Multifocal          | 1           1  1  1     1  1  1     1  1     1     1  1  2  1  2  1  1   |     38  1.2|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       | 2                                                                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  I  +  +  +  +|  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|             
                                           | 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      A                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      A                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      A                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly, Focal                    |                                                 2                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |       2  2  2                    2     2  2  3                 1  2  2  2|             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                      +            |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                             2            |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +                                                   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Acinus, Atrophy, Multifocal          |                                                                          |             
      Duct, Ectasia, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                      +                          +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +                                                   |             
      Atrium, Inflammation, Chronic, Focal |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +                                                   |             
      Capsule, Hyperplasia, Multifocal     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +              +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|             
                                           | 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +                 +  +  +     +  +                          +     +     +|             
      Angiectasis, Multifocal              |                                                                         3|             
      Follicle, Cyst                       |                   X  X  X     X  X                          X     X      |             
      Periovarian Tissue, Cyst             | X                       X                                               X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +        +  +  +  +     +  +  +  +     +  +  +     +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 3  3  2  3  2        2  3  3  4     2  2  2  2     3  3  3     3  3  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                 +              +        +                           |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                              4                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                 +              +                                    |             
      Lymphatic, Angiectasis, Diffuse      |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                 M              +                                    |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    2                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Chronic       |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 2  2  2  3  2  2  2  4  3  2  2  2  2  2  2  3  4  2  2  2  3  2  2  3  3|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      | 2  2  2  2  3  2  3  2  2  3  2  3  2  2  2  2  1  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  |                      M                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                      +                                                   |             
      Hyperplasia, Cystic, Multifocal      |                      1                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    |          +           +           +              +                        |             
      Ulcer                                |                                  3              4                        |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                  3                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 2| 3| 2| 2| 2| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 2|             
                                           | 8| 0| 9| 2| 9| 0| 9| 5| 8| 9| 0| 8| 0| 0| 0| 2| 0| 9| 0| 1| 2| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Chronic Active, Multifocal      |                                  3              3                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +                                                   |             
      Necrosis, Acute, Multifocal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                      +                                      +            |             
      Alveolus, Hemorrhage, Multifocal     |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +        +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +                       +                           |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                              3                           |             
      Capsule, Fibrosis, Chronic, Focal    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +              +  M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                 M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                 A                                                |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytomegaly, Focal                    |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2  2     3                       2  2  2  2  2        1     2  2  2     2|     24  2.0|
      Necrosis, Acute, Multifocal          |                                                                   2      |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                    2                     |      1  2.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   3        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                     4                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +              +  +           +                                    |   5        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                     4                                    |      1  4.0|
      Acinus, Atrophy, Multifocal          |                      3              3                                    |      2  3.0|
      Duct, Ectasia, Multifocal            |                                     4                                    |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                 +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                 +                                                |   3        |
      Atrium, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                 +                                      +         |   4        |
      Capsule, Hyperplasia, Multifocal     |       2                 3                                                |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                 +                                      +         |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                 +                                      +         |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +              +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +        +        +                                                |   6        |
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +     +  +              +                                +|  17        |
      Angiectasis, Multifocal              |                                                                          |      1  3.0|
      Follicle, Cyst                       | X  X           X     X                                                   |     11     |
      Periovarian Tissue, Cyst             |                                        X                                X|      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  42        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 3  3  2  3  3  3     4     3  4  2     3  3  2  3  2  2  3  3     3  2  3|     41  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +                 +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +              M  +                             +                  |   7        |
      Pancreatic, Inflammation, Chronic    |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +                 +                             M                  |   5        |
      Lymphatic, Angiectasis, Diffuse      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +              M  M                             +                  |   4        |
      Cyst                                 |                                                       X                  |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Inflammation, Chronic       |                                                                          |            |
          Active, Multifocal               |                                     3                                    |      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           | 2  2     3  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.2|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      | 2  1     2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 2| 7| 2| 3| 2| 3| 3| 6| 3| 3| 3| 3| 3| 3|            |
                                           | 9| 1| 2| 2| 0| 8| 9| 2| 1| 9| 1| 8| 9| 9| 0| 8| 2| 2| 7| 1| 0| 1| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M                 +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +                 +                                                |   3        |
      Hyperplasia, Cystic, Multifocal      |       2                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                 +                             +                  |   7        |
      Ulcer                                |                                                                          |      2  3.5|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                 +                                                |   3        |
      Necrosis, Acute, Multifocal          |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +              +  +                          +           +         |   7        |
      Alveolus, Hemorrhage, Multifocal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                 +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                 M                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                 +                                                |   4        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Capsule, Fibrosis, Chronic, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                 +                                                |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Clear Cell Focus, Focal              |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |                                                          3               |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                3                                            1            |             
      Necrosis, Chronic Active, Focal      |                                                                3         |             
      Centrilobular, Necrosis, Acute,      |                                                                          |             
          Multifocal                       |                                                       2                  |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |    2                                      3                          2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Acinus, Atrophy, Multifocal          |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Molar, Dysplasia                     |    3                                                                     |             
      Peridontal Tissue, Foreign Body,     |                                                                          |             
           Focal                           |                                  2                                       |             
      Peridontal Tissue, Foreign Body,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active, Focal           |                                  2                                       |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Capsule, Ectopic Tissue              |                X                                                     X   |             
      Capsule, Hyperplasia, Focal          | 2                                      2                                 |             
      Capsule, Hyperplasia, Multifocal     |       3  2  1  2     2  2  1  2  2  3     2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Focal                   |    2  2              2                       2                           |             
      Hypertrophy, Focal                   |          2  2                          2     2  2  2                     |             
      Hypertrophy, Multifocal              |                            2  2     2     2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Focal                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  M  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  +  M  +  +  +  M  M  M|             
      Pars Distalis, Cyst                  |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                               2                                          |             
      Follicle, Cyst, Multiple             |                                        X                                 |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Atrophy, Diffuse                     |                                                                          |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
      Duct, Dilatation, Multifocal         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +                 +  +  +  +           +  +           +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                          +               |             
      Neutrophilia                         |                                                          3               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse, Neutrophil     |                                                          4               |             
      Hyperplasia, Multifocal, Neutrophil  |                                                                          |             
      Thrombosis, Chronic Active           |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Proliferation, Multifocal        |                                                                3         |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
      Renal, Hyperplasia, Multifocal,      |                                                                          |             
          Plasma Cell                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                          3               |             
      Hyperplasia, Lymphoid, Multifocal    |                         3                                                |             
      Hyperplasia, Multifocal, Plasma Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  M  M  M  +  +  M  M  M  M  +  +  +  +  +  M  M  +  M  M  M  M  M|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                      2              2                    3               |             
      Hemorrhage, Multifocal               | 2                                      2  2     2                        |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 1  2  2  2  1  4  3  1  2  1  1  1  1  2  2  1  2  1  3  4  3  3  1  1  1|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      |    1     1        1  1  1  1  1  1  1  1  1  1  1  1  1        1     1  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  M  M  I  +  M  +  M  M  +  M  +  +  M|             
      Necrosis, Acute, Multifocal          |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Diffuse                  |                      2                                                   |             
      Acanthosis, Multifocal               |          2              3                                                |             
      Hyperkeratosis, Multifocal           |                                                                          |             
      Parasite External                    |                                  X  X  X                                 |             
      Ulcer                                |                                                 3                        |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Diffuse                          |                      3                                                   |             
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Multifocal      |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Joint, Radius,            |                                                                          |             
          Hyperostosis                     |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 7| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 0| 9| 6| 2| 3| 3| 2|             
                                           | 2| 1| 1| 1| 0| 2| 6| 0| 0| 1| 0| 9| 2| 0| 2| 8| 1| 0| 2| 1| 7| 8| 1| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Bilateral, Joint, Tarsal,            |                                                                          |             
          Hyperostosis                     |                      3     2                 3  3                        |             
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |             
           Multifocal, Osseous             |                      2     2                 2  2                        |             
      Joint, Tarsal, Hyperostosis          | 3              3        3     2     2     3                    3         |             
      Joint, Tarsal, Metaplasia,           |                                                                          |             
          Multifocal, Osseous              | 2              2        2     2     2     2                    2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                            3                                             |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Focal                    |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                            +   |             
      Cataract                             |                         3                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Dilatation, Diffuse          |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic, Focal          |                                                 3                       2|             
      Nephropathy, Chronic, Multifocal     |                                     3                          2         |             
      Bilateral, Hydronephrosis, Acute,    |                                                                          |             
           Multifocal                      |    2                                                                     |             
      Renal Tubule, Regeneration, Focal    |                                                                          |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       | 2  2  2  2           1  1  2  2  2     1  2  2     2        2     2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Submucosa, Congestion, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                      1   |      1  1.0|
      Clear Cell Focus, Focal              |                      X                                                   |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 4     2                                         3              2         |      6  2.5|
      Necrosis, Chronic Active, Focal      |                                                                          |      1  3.0|
      Centrilobular, Necrosis, Acute,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |             2                                                            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Multifocal          | 2                                   2                          2  2  2   |      6  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Molar, Dysplasia                     |                                                                          |      1  3.0|
      Peridontal Tissue, Foreign Body,     |                                                                          |            |
           Focal                           |                                                    2                     |      2  2.0|
      Peridontal Tissue, Foreign Body,     |                                                                          |            |
           Multifocal                      |                                     2                                    |      1  2.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Focal           |          2                                               3               |      3  2.3|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Multifocal      |                      2           2  3     3        3                    3|      6  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Ectopic Tissue              |                                                                          |      2     |
      Capsule, Hyperplasia, Focal          |                                                                          |      2  2.0|
      Capsule, Hyperplasia, Multifocal     | 2  2  3  2  2  2  2  2  2     2  2  3  2  2  1  3  2  2  2  2  2  2  2  2|     44  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   | 2                       2                    2  2     2  2     3         |     11  2.1|
      Hypertrophy, Focal                   |             1     2                                                  2   |      9  1.9|
      Hypertrophy, Multifocal              |                            2                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  M  +  +  +  I  M  +  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  40        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Follicle, Cyst, Multiple             |                                                                          |      1     |
      Follicular Cell, Hyperplasia, Focal  |                                                             1            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                               +                             +            |   2        |
      Atrophy, Diffuse                     |                               4                             4            |      2  4.0|
      Inflammation, Chronic Active, Diffuse|                               3                                          |      1  3.0|
      Duct, Dilatation, Multifocal         |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +           +  +        +        +     +                              |  19        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                                                        |   2        |
      Neutrophilia                         | 4                                                                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Diffuse, Neutrophil     |                                              3  3                        |      3  3.3|
      Hyperplasia, Multifocal, Neutrophil  | 3                                                                        |      1  3.0|
      Thrombosis, Chronic Active           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation, Diffuse           | 3                                                                        |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation, Multifocal        |       2                                                                  |      2  2.5|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Multifocal        | 3                                                                        |      1  3.0|
      Renal, Hyperplasia, Multifocal,      |                                                                          |            |
          Plasma Cell                      |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid, Multifocal    |                                                    2                     |      2  2.5|
      Hyperplasia, Multifocal, Plasma Cell |                                              3  3                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  +  M  M  M  M  +  M  +  M  +  +  M  +  +  +  +  M  +  +  M  M  M|  22        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |       3  3                    3        2           3  3     2            |     10  2.6|
      Hemorrhage, Multifocal               |                                                                          |      4  2.0|
      Hyperplasia, Diffuse, Lymphoid       |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Red Pulp, Fibrosis                   |                                                                   2      |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           | 4  2  3  3  1  4  2  1  1  1  2  1  2  1  2  3  3  2  1  1  1  3  3  1  1|     50  1.9|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      |    1  1  1  1        1  1  1  1  1  1  1  1  1  1  1  1  1           1  1|     37  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  M|  36        |
      Necrosis, Acute, Multifocal          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis, Diffuse                  |                                                                          |      1  2.0|
      Acanthosis, Multifocal               |    3                                3  3     3  3  3  3                  |      9  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis, Multifocal           |                                              3                           |      1  3.0|
      Parasite External                    |          X  X                                X     X                     |      7     |
      Ulcer                                |    2     3                             4     2  4                        |      6  3.0|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Diffuse                          |                                                                          |      1  3.0|
      Subcutaneous Tissue, Fibrosis, Focal |                                        2                                 |      1  2.0|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |    2     3                                   3  4     3                  |      5  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Joint, Radius,            |                                                                          |            |
          Hyperostosis                     |                                                                          |      1  3.0|
      Bilateral, Joint, Tarsal,            |                                                                          |            |
          Hyperostosis                     |                   3           3           3     2     3  2               |     10  2.7|
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |            |
           Multifocal, Osseous             |                   2           2           2     2     2  2               |     10  2.0|
      Joint, Tarsal, Hyperostosis          |          3                             3     2                    2      |     11  2.6|
      Joint, Tarsal, Metaplasia,           |                                                                          |            |
          Multifocal, Osseous              |          2                             2     2                    2      |     11  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Focal                    |                                        2                                 |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 3| 3| 5| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2|            |
                                           | 8| 8| 8| 1| 2| 4| 2| 1| 0| 2| 0| 8| 2| 2| 1| 1| 0| 1| 0| 2| 1| 8| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Dilatation, Diffuse          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic, Focal          |          2                                                               |      3  2.3|
      Nephropathy, Chronic, Multifocal     |                                                                          |      2  2.5|
      Bilateral, Hydronephrosis, Acute,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Renal Tubule, Regeneration, Focal    |                            1                                             |      1  1.0|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       | 1  2  2           2  2  1        2  2  1  2     2        2  1  2  1  2  1|     33  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                   3                                                      |      1  3.0|
      Submucosa, Congestion, Multifocal    |                                                                2         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|             
                                           | 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A                                                        A         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                                +                       +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       A                                                        A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                                +                       +         |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Necrotizing                     |                                                                3         |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       A                                                        A         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                           2        2                     |             
      Inflammation                         |          1                                                               |             
      Necrosis, Chronic Active, Multifocal |       4                                                                  |             
      Vacuolization Cytoplasmic, Focal     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                                                        +         |             
      Capsule, Hyperplasia, Focal          |       1                                                                  |             
      Capsule, Hyperplasia, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       A                                                        M         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                                                        M         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|             
                                           | 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion, Chronic Active,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                +  +      |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                   4      |             
      Duct, Dilatation, Focal              |                                                                4         |             
                                            __________________________________________________________________________|             
   Prostate                                |       +                                                        +         |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       A                                                        +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +           +     +  +     +           +  +     +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +     +                                                  +         |             
      Depletion Lymphoid, Diffuse          |                                                                3         |             
      Hyperplasia, Lymphoid, Multifocal    | 2           3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +              +     +  +     +           +  +     +  M  +      |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    3     3              3     4  3     3           2  3     3     3      |             
      Inflammation, Multifocal, Suppurative|                                  4                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Follicle, Depletion         |                                                                          |             
          Lymphoid, Multifocal             |                                                                3         |             
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Red Pulp, Fibrosis, Multifocal       |                                              2                           |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 2  2  3  2  2     2  2  2     2  3  3  3  2  2  2  2  2  2  2  3  3  2  2|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      | 2  2  1  2  2     1  2  2     2  2  2  2  2  2  2  2  2  2  2  1  1  1  2|             
                                            __________________________________________________________________________|             
   Thymus                                  |       I                                                        M         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M                                                        M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +     +  +     +        +        +           +  +  +  +      |             
      Acanthosis, Diffuse                  |          3  3                                2                           |             
      Acanthosis, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|             
                                           | 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis, Multifocal               | 3                                                              2  3      |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       | 2                                                                        |             
      Ulcer                                | 2                 4  2              3                                    |             
      Sebaceous Gland, Hyperplasia, Focal  |                                                                          |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Diffuse                          |          2                                                               |             
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute, Multifocal               |                            3                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                   3                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Focal           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Multifocal      |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +           +  +        +        +  +        +  +  +  +     +|             
      Bilateral, Joint, Tarsal,            |                                                                          |             
          Hyperostosis                     | 3        2  3           3  2        2        3  3        3  2     3     3|             
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |             
           Multifocal, Osseous             | 2        2  2           2  2        2        2  2        2  2     2     2|             
      Joint, Tarsal, Hyperostosis          |                                                                          |             
      Joint, Tarsal, Metaplasia,           |                                                                          |             
          Multifocal, Osseous              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +                                               +        +         |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                                                        +         |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                            +           M        +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 7| 3| 3| 3| 2| 3| 3| 1| 2| 7| 3| 0| 3| 6| 3| 3| 3| 2| 2| 4| 7| 2| 3|             
                                           | 9| 1| 9| 2| 0| 3| 8| 2| 0| 4| 9| 4| 0| 8| 2| 7| 2| 1| 2| 8| 9| 6| 4| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infarct, Chronic, Focal              |                                                                          |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Mineralization, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     A     +                                               +  +         |             
      Dilatation, Diffuse                  | 4           4                                               4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3|            |
                                           | 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                      A                    A                          A   |            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                      +                    +                          +   |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      M                    +                          A   |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                      +                    +                          +   |   6        |
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Necrotizing                     |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                      X   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                      A                    +                          A   |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                 +                    +                          A   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                      I                    +                          A   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                      M                    +                          A   |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                 +                    +                          A   |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                        2                 2               |      4  2.0|
      Inflammation                         |                                                                          |      1  1.0|
      Necrosis, Chronic Active, Multifocal |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                      +                    +                          A   |   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                      +                    +                          +   |   5        |
      Capsule, Hyperplasia, Focal          |                                                                          |      1  1.0|
      Capsule, Hyperplasia, Multifocal     |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                      I                    +                          +   |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                      +                    +                          A   |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                      +                    +                          +   |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                      +                    +                          M   |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3|            |
                                           | 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                      +                                                   |   1        |
      Concretion, Chronic Active,          |                                                                          |            |
          Multifocal                       |                      3                                                   |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                     +                                    |   3        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                     4                                    |      2  4.0|
      Duct, Dilatation, Focal              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                      +                    +                          M   |   4        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                      +                    +                          A   |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +           +     +  +        +  +  +  +        +  +              +   |  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                      +  +                 +                          +   |   8        |
      Depletion Lymphoid, Diffuse          |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid, Multifocal    |                         3                                                |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +           +     M  +        +  +  +  M        +  +              M   |  19        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    3           3        3        3  2  3           2  3                  |     18  2.9|
      Inflammation, Multifocal, Suppurative|                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  47        |
      Lymphoid Follicle, Depletion         |                                                                          |            |
          Lymphoid, Multifocal             |                                                                          |      1  3.0|
      Lymphoid Follicle, Necrosis, Acute,  |                                                                          |            |
           Multifocal                      |                      3                                                   |      1  3.0|
      Red Pulp, Fibrosis, Multifocal       |                                                                          |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3|            |
                                           | 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation, Diffuse           | 2  2  3  2  3  3  2  3  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2|     47  2.2|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1     1|     47  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                      M                    A                          M   |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                      M                    M                          M   |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +  +  +  +  M  +           +  +  +     +              +  +|  27        |
      Acanthosis, Diffuse                  |                                                                          |      3  2.7|
      Acanthosis, Focal                    |                                              3                          3|      2  3.0|
      Acanthosis, Multifocal               |             3                                                            |      4  2.8|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Ulcer                                |       3     2  3        3                    2                           |      9  2.7|
      Sebaceous Gland, Hyperplasia, Focal  |                                                                         2|      1  2.0|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Diffuse                          |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis, Focal |          3                                   2                           |      2  2.5|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |       3        3  3                                                      |      4  2.8|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute, Multifocal               |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Diffuse         |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Focal           |             2     3                                                      |      2  2.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |       3  2     3        3                                                |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +     +  +                 +  +  +  +  +  +  +           +  +|  28        |
      Bilateral, Joint, Tarsal,            |                                                                          |            |
          Hyperostosis                     |       3     2     3                    3     3  3     3  3              3|     21  2.8|
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |            |
           Multifocal, Osseous             |       2     2     2                    2     2  2     2  2              2|     21  2.0|
      Joint, Tarsal, Hyperostosis          |          2                                         2                     |      2  2.0|
      Joint, Tarsal, Metaplasia,           |                                                                          |            |
          Multifocal, Osseous              |          2                                         2                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 2| 0| 2| 3| 0| 3| 3| 2| 2| 3| 7| 2| 3| 2| 6| 3| 2| 3| 2| 3| 3|            |
                                           | 8| 1| 0| 0| 9| 3| 9| 2| 3| 2| 1| 8| 9| 1| 5| 8| 1| 9| 7| 2| 8| 0| 9| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                      +           +        +  +              +        +  +|  10        |
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                      +                    +                          +   |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                      +                    +                          +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                    +                          M   |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                   +  +                    +                          +   |   6        |
      Infarct, Chronic, Focal              |                   3                                                      |      1  3.0|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |                      3                    3                          4   |      3  3.3|
      Mineralization, Focal                |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +              +  +     +           A                          A   |   8        |
      Dilatation, Diffuse                  |       4              3  4     3                                          |      7  3.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Crystals, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |    X                                X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                         2|             
      Angiectasis, Multifocal              |                                        3                                 |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                2         |             
      Inflammation, Acute, Multifocal      | 2                                                                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Acute, Multifocal          |                                                                          |             
      Necrosis, Chronic Active, Multifocal |                                        4                                 |             
      Thrombosis, Chronic                  |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                            2                                             |             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Acinus, Atrophy, Focal               |                                     1                                    |             
      Acinus, Atrophy, Multifocal          |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Incisor, Dysplasia, Multifocal       | 3                                                                        |             
      Molar, Dysplasia                     |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active, Focal           |                            2           3                             3   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Chronic Active, Multifocal      | 3                                                  3     2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active, Focal            |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |                                                                          |             
      Capsule, Hyperplasia, Multifocal     | 2     2  2  2     2  2  2  3  2  2     2  3  3  2  2  2  3     2  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Hyperplasia, Focal                   |                   2                                2     3               |             
      Hyperplasia, Multifocal              |                      2                                                   |             
      Hypertrophy, Focal                   |                      2           2                                      2|             
      Necrosis, Acute, Focal               |                                                                         2|             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  M  M  +  I  M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst, Multiple        |                                     X                                    |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2                                             |             
      Inflammation, Chronic, Multifocal    | 2                                                                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +     +                                +                        |             
      Atrophy, Multifocal                  |                                                 4                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |          3                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +                    +  +                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration,   |                                                                          |             
           Chronic, Multifocal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse, Neutrophil     |                                              4           3               |             
      Femoral, Angiectasis, Focal          |                3                          3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal, Plasma Cell |                                              3           3               |             
      Lymphocyte, Necrosis, Multifocal     |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  +  +  +  M  M  +|             
      Hematocyst, Chronic Active           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2                                                     3     2  2        2|             
      Hyperplasia, Lymphoid, Multifocal    |                                                             3            |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Red Pulp, Angiectasis, Focal         |                                                                2         |             
      Red Pulp, Fibrosis, Multifocal       |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 2  2     3  2     2  2  2  2  3  2  3  3  2  3  2  2  2  3  2  3  3  2  2|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      | 2  2     2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  1  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  M  +  M  M  +  +  M  M  +  I  +  M  +  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Depletion Lymphoid, Multifocal       |                                                                          |             
      Necrosis, Acute, Multifocal          |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Diffuse                  |                   2              3                                       |             
      Acanthosis, Focal                    |             3                                                            |             
      Acanthosis, Multifocal               | 3                                   3     3  3                 3        2|             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis, Multifocal           |                                                                3         |             
      Parasite External                    |                               X     X        X  X  X     X     X         |             
      Ulcer                                |                                           2  4                           |             
      Ulcer, Multiple                      |                                     4                          4        2|             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Diffuse                          |                                  2                                       |             
      Subcutaneous Tissue, Fibrosis, Focal |             2                                                            |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                   3                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Focal           |                               2                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Multifocal      |                                     3        4  4        3     3        2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Joint, Tarsal,            |                                                                          |             
          Hyperostosis                     |                               2        3                    3  2         |             
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |             
           Multifocal, Osseous             |                               2        2                    2  2         |             
      Joint, Tarsal, Hyperostosis          |       3  3  3     3              3           3                    2     2|             
      Joint, Tarsal, Metaplasia,           |                                                                          |             
          Multifocal, Osseous              |       2  2  2     2              2           2                    2     2|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    2                             3              2                        |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Diffuse                         |       2                                                                  |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Acute, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                     +                  |             
      Cataract                             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 9| 9| 3| 3| 2| 3| 3| 2| 2| 7| 3| 3| 2| 2| 2| 2| 2| 3| 2| 3| 2| 0| 3| 3|             
                                           | 1| 0| 9| 2| 0| 9| 1| 2| 9| 9| 4| 1| 1| 8| 8| 9| 9| 8| 2| 8| 2| 8| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Multifocal    | 4                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +|             
      Acinus, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                X         |             
      Nephropathy, Chronic, Focal          |                                                          3               |             
      Nephropathy, Chronic, Multifocal     |    2                                                           2         |             
      Cortex, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |          3                                                               |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
      Renal Tubule, Atypia Cellular,       |                                                                          |             
          Multifocal                       |                                                                2         |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |                                                                2         |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin, Multifocal          |                2        2              3                                 |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                2  2  1  1  2  2  1     2  2  2  2  2  2     2  2  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Necrosis, Acute,          |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lumen, Crystals, Diffuse             |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |       X                                                                  |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                       2                  |      2  2.0|
      Angiectasis, Multifocal              |                                        4                 4               |      3  3.7|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |                                        1                          3      |      2  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                   2                 3                                    |      3  2.3|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                              2                           |      1  2.0|
      Necrosis, Acute, Multifocal          |                                        2                                 |      1  2.0|
      Necrosis, Chronic Active, Multifocal |                   4           4                 4     3  4               |      6  3.8|
      Thrombosis, Chronic                  |                                        X        X                        |      2     |
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |                         2                    2     2                     |      4  2.0|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic, Multifocal    |                   2                                                      |      1  2.0|
      Acinus, Atrophy, Focal               |                                                                          |      1  1.0|
      Acinus, Atrophy, Multifocal          |                                  2                                2     2|      4  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Incisor, Dysplasia, Multifocal       |                                                                          |      1  3.0|
      Molar, Dysplasia                     |                                        2                                 |      1  2.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Focal           |                                        3                                 |      4  2.8|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active, Multifocal      |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active, Focal            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Hyperplasia, Focal          |                                                                   2      |      1  2.0|
      Capsule, Hyperplasia, Multifocal     | 2  2     2  2  1  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2     2  2|     44  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X                                                                     |      2     |
      Hyperplasia, Focal                   |    2                                                     2               |      5  2.2|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |          2  2                    2                          2  2  2     2|     10  2.0|
      Necrosis, Acute, Focal               |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  M  M  M  +  +  +  +  M|  38        |
      Cyst                                 |                                           X                              |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  41        |
      Pars Distalis, Cyst                  |                   X              X                                       |      2     |
      Pars Distalis, Cyst, Multiple        |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Lymphocyte                      |                                     2                                    |      2  2.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                            2                 2  2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +              +                                                   |   5        |
      Atrophy, Multifocal                  |                                                                          |      1  4.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Diffuse         |                         2                                                |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                 3                        |      1  3.0|
      Epithelium, Hyperplasia, Focal       |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Degeneration,   |                                                                          |            |
           Chronic, Multifocal             |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Diffuse, Neutrophil     |       3  3                                            2                  |      5  3.0|
      Femoral, Angiectasis, Focal          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation, Multifocal        |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Hyperplasia, Multifocal, Plasma Cell |             3                                                            |      3  3.0|
      Lymphocyte, Necrosis, Multifocal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  M  M  M  M  +  M  M  +  M  +  M  +  +  M  +  M  +  M  +  M  +  M  M|  17        |
      Hematocyst, Chronic Active           |                                                       4                  |      1  4.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    2              3        3     3     3  3     3           3     3      |     14  2.6|
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |      1  3.0|
      Inflammation, Chronic, Multifocal    |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                      2                 1                                 |      2  1.5|
      Red Pulp, Angiectasis, Focal         |                                                                          |      1  2.0|
      Red Pulp, Fibrosis, Multifocal       |                                                                      2   |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation, Diffuse           | 2  2  4  4  2  2  3  2  2  2  2  2  3  3  3  2  4  2  3  3  2  2  3  1  1|     48  2.4|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      | 2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2|     48  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  M  +  M  +  +  +  +  +  I  M  M  M  +  M  +  M  M  I  +  M  +  +|  27        |
      Cyst, Multiple                       |                                                                      X   |      1     |
      Depletion Lymphoid, Multifocal       |             3                                                            |      1  3.0|
      Necrosis, Acute, Multifocal          |                         3                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis, Diffuse                  |                      3                                                  2|      4  2.5|
      Acanthosis, Focal                    |                                                                          |      1  3.0|
      Acanthosis, Multifocal               |                            3                                             |      7  2.9|
      Alopecia                             |                                           3                              |      1  3.0|
      Hyperkeratosis, Multifocal           |                                                                          |      1  3.0|
      Parasite External                    | X     X     X  X                                X                        |     12     |
      Ulcer                                |       4  3                                                              3|      5  3.2|
      Ulcer, Multiple                      |                            2                                             |      4  3.0|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Diffuse                          |                      2                                                  3|      3  2.3|
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |                            3                                             |      2  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Focal           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |       3                                                                  |      7  3.1|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Joint, Tarsal,            |                                                                          |            |
          Hyperostosis                     | 3  3  3  2  3        2                                   3               |     11  2.6|
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |            |
           Multifocal, Osseous             | 2  2  2  2  2        2                                   2               |     11  2.0|
      Joint, Tarsal, Hyperostosis          |                                           3                              |      9  2.8|
      Joint, Tarsal, Metaplasia,           |                                                                          |            |
          Multifocal, Osseous              |                                           2                              |      9  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                            3                                             |      4  2.5|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Acute, Multifocal               |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   3        |
      Cataract                             |                                                                          |      1  2.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +|  40        |
      Acinus, Hyperplasia, Multifocal      |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy, Chronic, Focal          |                                                                          |      1  3.0|
      Nephropathy, Chronic, Multifocal     |                                                       3  3     2  2     2|      7  2.3|
      Cortex, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          |                                     3                                    |      1  3.0|
      Renal Tubule, Atypia Cellular,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin, Multifocal          |                                                                   2      |      4  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 6| 2| 2| 3| 3| 2| 2| 2| 0| 2| 9| 3| 8| 3| 2| 3| 8| 8| 3| 2| 8| 3| 2|            |
                                           | 8| 2| 7| 5| 8| 2| 0| 8| 4| 9| 2| 9| 0| 1| 2| 0| 2| 2| 8| 2| 2| 9| 2| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |    2  2  2     2  2  2     2     2  2  2  1        2                 2   |     30  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submucosa, Necrosis, Acute,          |                                                                          |            |
          Multifocal                       |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +              +        +                          +     M            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    A              A        +                          +     A  +         |             
      Necrosis, Acute, Multifocal          |                                                                3         |             
      Submucosa, Fibrosis, Diffuse         |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +              A        +                          +     A            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +              A        +                          +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +              +        +     +                    +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +              A        +                          +     +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +              A        +                          +     M            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +              +        +     +                    +     +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition, Multifocal       |                                  3                                       |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                      1   |             
      Inflammation, Chronic, Multifocal    |                      3           2                                       |             
      Necrosis, Chronic Active, Multifocal |                                  3                                       |             
      Necrosis, Coagulative, Focal         |                                                                4         |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                3         |             
      Hepatocyte, Cytomegaly, Diffuse      |                                                                          |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +              +        +                          +     +            |             
      Capsule, Hyperplasia, Multifocal     |                   3                                   2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M              M        M                          M     +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    I              M        +                          M     +            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +           +                                            +  +|             
      Atrophy, Multifocal                  |                                                                      3   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                         3|             
      Inflammation, Multifocal, Suppurative|                         3                                                |             
      Duct, Dilatation, Focal              |             3                                                            |             
      Duct, Dilatation, Multifocal         |                                                                      4  3|             
                                            __________________________________________________________________________|             
   Prostate                                |    +              +        +                          +     +            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Neutrophilia                         |    X                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +              +        +                          +     +            |             
      Hyperplasia, Diffuse, Neutrophil     |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +  +  +  +  +  +           +     +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +              +        +                 +        +     +            |             
      Hyperplasia, Lymphoid, Multifocal    |                                              2                           |             
      Hyperplasia, Multifocal, Plasma Cell |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    M              M  +  +  M  +  +           +     +  M     M  +  +     +|             
      Angiectasis, Multifocal              |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                      2  2     3  2           3     3           3  3     2|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition, Multifocal       |                                  3                                       |             
      Angiectasis, Focal                   |                                                                1         |             
      Angiectasis, Multifocal              |             2                                                            |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 2  4  2  3  2  2  3  1  3  2  3  4     2  2  2  2  2  2  2  2  3  3  2  2|             
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |             
           Multifocal                      | 2     2  2  1  2     1  1  1  1  1     2  2  2  2  2  1  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  |    M              M        M                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M              M        M                          M     M            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  M  +     +           +  +     +     +      |             
      Acanthosis, Diffuse                  | 3     3                                            3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acanthosis, Multifocal               |                3                                                         |             
      Ulcer                                |       3        3  4  3                                                   |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Diffuse                          | 3     3                                            3                     |             
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |             
      Subcutaneous Tissue, Fibrosis,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                      4                                                   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Multifocal      |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Multifocal                      |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +  +  +              +  +  +  +  +  +  +      |             
      Bilateral, Joint, Tarsal,            |                                                                          |             
          Hyperostosis                     |       3  2  2        3  3     3  3              3  3           3         |             
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |             
           Multifocal, Osseous             |       2  2  2        2  2     2  2              2  2           2         |             
      Joint, Tarsal, Hyperostosis          |                   3                                      2        2      |             
      Joint, Tarsal, Metaplasia,           |                                                                          |             
          Multifocal, Osseous              |                   2                                      2        2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +        +     +  +                          +     +     +      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +              +        +                          +     +            |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Acute, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +              +        +                          +     +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Lens, Cataract, Multifocal           |                            4                                             |             
      Retina, Atrophy, Multifocal          |                            3                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    M              +        +                          M  +  +            |             
      Inflammation, Chronic Active,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 4| 7| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 8| 3| 5| 2| 2| 4| 2| 6| 2| 2| 6| 8| 3| 3| 2| 3| 3| 8| 3| 1| 3| 3| 3| 3|             
                                           | 9| 9| 0| 5| 8| 8| 3| 9| 6| 6| 8| 7| 7| 1| 0| 9| 2| 0| 4| 2| 4| 1| 2| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +              +        +     +                    +     +            |             
      Amyloid Deposition, Multifocal       |                                  3                                       |             
      Infarct, Chronic, Focal              |                                                                          |             
      Nephropathy, Chronic, Multifocal     |                            2     4                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +              +  +     +                          +     +            |             
      Dilatation                           |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +                             +                           |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +                             A                           |   4        |
      Necrosis, Acute, Multifocal          |                                                                          |      1  3.0|
      Submucosa, Fibrosis, Diffuse         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +                             A                           |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +                             A                           |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +                             +                       +   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +                             +                           |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                M                             A                           |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +                             A                       +   |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Amyloid Deposition, Multifocal       |                                                                          |      1  3.0|
      Cyst                                 |                                              X                           |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                                           3                              |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |       1  2           1                          2        2               |      6  1.5|
      Inflammation, Chronic, Multifocal    |                                                                          |      2  2.5|
      Necrosis, Chronic Active, Multifocal |                                                                          |      1  3.0|
      Necrosis, Coagulative, Focal         |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia, Multifocal   |                                     4                                    |      2  3.5|
      Hepatocyte, Cytomegaly, Diffuse      |                                     4                                    |      1  4.0|
      Hepatocyte, Hyperplasia, Focal       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                             +                           |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +                          +                           |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +                             +                           |   7        |
      Capsule, Hyperplasia, Multifocal     |                1                             1                           |      4  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +                             +                           |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                M                             +                           |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M                             M                           |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +                             +                           |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +                             +                           |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                   +        +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                      +                                                   |   5        |
      Atrophy, Multifocal                  |                                                                          |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Inflammation, Multifocal, Suppurative|                      4                                                   |      2  3.5|
      Duct, Dilatation, Focal              |                                                                          |      1  3.0|
      Duct, Dilatation, Multifocal         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +                             +                           |   7        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                               +                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                +                             +                           |   7        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +                                                         |   2        |
      Neutrophilia                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +                             +                           |   7        |
      Hyperplasia, Diffuse, Neutrophil     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +  +  +  +     +     +     +     +           +        +  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +  +                             +                           |   9        |
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |      1  2.0|
      Hyperplasia, Multifocal, Plasma Cell |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +     +     +     +     +     +     M           +        +  +  +|  20        |
      Angiectasis, Multifocal              |                                        3                                 |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |       2  4           2     3     3     3                 2        3     3|     18  2.7|
      Inflammation, Focal, Granulomatous   |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Amyloid Deposition, Multifocal       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis, Focal                   |                                                                          |      1  1.0|
      Angiectasis, Multifocal              |                                                                          |      1  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           | 2  2  2  4  1  2  3  2  3  4  3  2  3  3  2  3  2  2  3  4  3  2  2  3  3|     49  2.5|
      Red Pulp, Pigmentation, Hemosiderin, |                                                                          |            |
           Multifocal                      | 2  2  2  1  1        2  1  1  2  2  1  1  2  1  2  2  2  1  2  2  2  2  2|     45  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +                             M                           |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M                             M                           |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +     +     +  +  +                 +  +  +     +  +     +  +  +|  28        |
      Acanthosis, Diffuse                  |                                                                   3  2   |      5  2.8|
      Acanthosis, Multifocal               |                                                             3            |      2  3.0|
      Ulcer                                |          4              3  3                                3            |      8  3.3|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Diffuse                          |                                                                   3      |      4  3.0|
      Subcutaneous Tissue, Fibrosis, Focal |                                                                      3   |      1  3.0|
      Subcutaneous Tissue, Fibrosis,       |                                                                          |            |
          Multifocal                       |                                                          4               |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Diffuse         |                                                             4            |      2  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Multifocal      |                                                    3                     |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Multifocal                      |                                                          3               |      1  3.0|
      Subcutaneous Tissue, Mineralization, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +        +           +           +     +        +  +  +     +      |  26        |
      Bilateral, Joint, Tarsal,            |                                                                          |            |
          Hyperostosis                     |       3                    2           2                 2  2     3      |     16  2.6|
      Bilateral, Joint, Tarsal, Metaplasia,|                                                                          |            |
           Multifocal, Osseous             |       2                    2           2                 2  2     2      |     16  2.0|
      Joint, Tarsal, Hyperostosis          |                                                       2                  |      4  2.3|
      Joint, Tarsal, Metaplasia,           |                                                                          |            |
          Multifocal, Osseous              |                                                       2                  |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05020-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 14:10:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 6|            |
                             DAY ON TEST   | 2| 3| 2| 6| 2| 1| 0| 3| 6| 0| 2| 3| 3| 7| 3| 2| 2| 7| 2| 2| 2| 8| 2| 6| 6|            |
                                           | 9| 1| 9| 7| 8| 1| 3| 1| 7| 3| 4| 0| 2| 4| 0| 3| 9| 4| 9| 9| 9| 7| 9| 7| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +                             +                           |   7        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +     +     +  +              +        +                  |  14        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +                             +                           |   7        |
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Acute, Multifocal               |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +                             +                           |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract, Multifocal           |                                                                          |      1  4.0|
      Retina, Atrophy, Multifocal          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                             +     +                     |   7        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +                             +  +                       +|  10        |
      Amyloid Deposition, Multifocal       |                                                                          |      1  3.0|
      Infarct, Chronic, Focal              |                                                 4                        |      1  4.0|
      Nephropathy, Chronic, Multifocal     |                                                                         3|      3  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +              +              +           +     +         |  11        |
      Dilatation                           |                               3                          3     4         |      4  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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