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TR 351 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/03/94   
EXP: 05020                   PARA-CHLOROANILINE                TIME: 20:08:06   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 02039B   
CONT: NO1CP9565302                                             CAS: 106-47-8    
PATHOLOGIST: R. PERSING                                                         
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/03/94  
EXP: 05020                   PARA-CHLOROANILINE                TIME: 20:08:06  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 02039B  
CONT: NO1CP9565302                                             CAS: 106-47-8   
PATHOLOGIST: R. PERSING                                                        

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      496   502   541   591   654   667   672                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 1    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      246   375   432   479   637   667   667   674   674   703                 |
 |      703   708   714                                                           |
 |  CENSORED DEATHS                                                               |
 |      133                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      389   423   443   511   514   526   584   655   666   666                 |
 |      667   667   667   667   674   674   687   687   703   703                 |
 |      724                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 30 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      399   490   502   524   600   628   667   674   682   682                 |
 |      682   688   690   722   725                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  92.0  90.0  86.0      |
 |           |                                                                    |
 |           |                                                                    |
 |3 MG/KG    |   100.0 100.0  98.0  98.0  95.9  91.8  91.8  91.8  89.8  73.5      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/KG   |   100.0 100.0 100.0 100.0  96.0  94.0  88.0  86.0  84.0  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/KG   |   100.0 100.0 100.0 100.0  98.0  98.0  92.0  90.0  88.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       86.0%        73.5%        58.0%        70.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.295      P=0.211      P=0.005      P=0.110  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       589.0        590.7        614.1        623.7    |
 |NATURAL DEATHS (C)      |       (29.2)       (42.7)       (22.3)       (25.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       708.5        680.4        680.2        696.7    |
 |(STANDARD ERROR)        |       ( 7.9)       (17.7)       (12.2)       (10.1)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 1    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      143   480   527   666   672   695   695   714   717   723                 |
 |  CENSORED DEATHS                                                               |
 |      1                                                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 3 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 5      CENSORED DEATHS 3    TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      439   528   682   709   714                                               |
 |  CENSORED DEATHS                                                               |
 |      1     1     2                                                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      521   532   625   667   672   679                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 30 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      458   550   609   616   637   667   702   704   722                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                PARA-CHLOROANILINE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0  98.0  98.0  98.0  98.0  95.9  93.9  93.9  93.9  79.6      |
 |           |                                                                    |
 |           |                                                                    |
 |3 MG/KG    |   100.0 100.0 100.0 100.0 100.0  97.9  95.7  95.7  95.7  89.4      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/KG   |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  96.0  94.0  88.0      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/KG   |   100.0 100.0 100.0 100.0 100.0  98.0  98.0  96.0  90.0  82.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       79.6%        89.4%        88.0%        82.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.875      P=0.298N     P=0.408N     P=0.966N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       603.2        614.4        616.0        629.4    |
 |NATURAL DEATHS (C)      |       (57.5)       (55.5)       (29.4)       (28.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       688.5        673.0        714.6        710.3    |
 |(STANDARD ERROR)        |       (19.2)       (25.2)       ( 6.1)       ( 7.3)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         PARA-CHLOROANILINE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        3 MG/KG          = 2
                                                        10 MG/KG         = 3
                                                        30 MG/KG         = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                       2                     34              1
      |
      |                                         2                  2  34   3         411
      |                                                            2       32 3      4 1      1
   95 +
      |                                                                     2 3     2  43  4  1       1
      |                                                                                 33 4          14       1
      |                                                                             2                       2
   90 +                                                                                  3  3          4   42  1  1
      |
P     |                                                                                     3       3      4      4
E     |                                                                                             3          3  12      1
R  85 +
C     |                                                                                                        3  344
E     |
N     |                                                                                                            2   2
T  80 +
      |
S     |                                                                                                             44 22
U     |
R  75 +
V     |                                                                                                              4  2 2
I     |                                                                                                           33
V     |
A  70 +                                                                                                                   4
L     |
      |                                                                                                            3 3
      |
   65 +
      |                                                                                                              3 3
      |
      |
   60 +                                                                                                                3  3
      |
      |                                                                                                                   3
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.

                                                         PARA-CHLOROANILINE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        3 MG/KG          = 2
                                                        10 MG/KG         = 3
                                                        30 MG/KG         = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

        |
        |
  100.0 +1                      1                                             2   4         3
        |
        |
        |                       1                                             2   4  1      32  4
   97.5 +
        |
        |                                                                                    3  4        4  3
        |                                                                            1       1                       2
   95.0 +
        |
P       |                                                                                    1           44 3      1 2   2
E       |
R  92.5 +
C       |                                                                                                 4  4
E       |
N       |
T  90.0 +                                                                                                    4     13  1
        |                                                                                                                2 2
S       |
U       |                                                                                                          43   4  3
R  87.5 +
V       |
I       |
V       |                                                                                                              1 1
A  85.0 +
L       |
        |                                                                                                               4114
        |
   82.5 +
        |                                                                                                                 11
        |
        |
   80.0 +
        |                                                                                                                  1
        |
        |
   77.5 +
        |
        -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
         0         10         20         30         40         50         60         70         80         90         100        110

                                                                    WEEK

NOTE: 9 obs hidden.