National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2874

TR 351 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         PARA-CHLOROANILINE


NTP Experiment-Test: 05020-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 18:08:57




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  000106478

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                              15            5           11            8                                     
    Moribund                                           8            6            3            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           39           36           37                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (8)          (12)         (50)                                   
      Foreign Body                                     6 (12%)      1 (13%)      3 (25%)                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Large, Cecum                             (40)         (4)          (3)          (46)                                   
      Inflammation, Chronic Active                                  1 (25%)                                                         
      Parasite Metazoan                                1 (3%)       1 (25%)                   1 (2%)                                
   Intestine Large, Colon                             (47)         (6)          (8)          (46)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Inflammation, Necrotizing                                                  1 (13%)                                            
      Parasite Metazoan                                4 (9%)                    1 (13%)      3 (7%)                                
   Intestine Large, Rectum                            (45)         (3)          (6)          (47)                                   
      Parasite Metazoan                                3 (7%)                    1 (17%)      2 (4%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                38 (76%)     45 (90%)     46 (92%)     44 (88%)                               
      Clear Cell Focus                                              1 (2%)                    3 (6%)                                
      Degeneration, Cystic                                          1 (2%)                                                          
      Degeneration, Fatty                              1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       5 (10%)      2 (4%)       2 (4%)       3 (6%)                                
      Inflammation, Chronic                           32 (64%)     30 (60%)     32 (64%)     36 (72%)                               
      Inflammation, Necrotizing                        1 (2%)       1 (2%)       3 (6%)       1 (2%)                                
      Necrosis, Coagulative                                                      2 (4%)       1 (2%)                                
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Vacuolization Cytoplasmic                        3 (6%)       3 (6%)                    1 (2%)                                
      Bile Duct, Hyperplasia                           8 (16%)      3 (6%)       1 (2%)       9 (18%)                               
      Portal Vein, Intima, Proliferation                                         1 (2%)                                             
   Mesentery                                          (49)         (7)          (11)         (47)                                   
      Inflammation, Chronic                                         2 (29%)      2 (18%)      8 (17%)                               
      Necrosis                                                      2 (29%)                   1 (2%)                                
   Pancreas                                           (50)         (6)          (12)         (49)                                   
      Ectopic Tissue                                                                          1 (2%)                                
      Inflammation, Chronic                                                      2 (17%)      2 (4%)                                
      Acinus, Atrophy                                 13 (26%)      1 (17%)      3 (25%)     15 (31%)                               
   Pharynx                                            (1)                                                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                     1 (100%)                                                                     
   Salivary Glands                                    (50)         (8)          (12)         (49)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
   Stomach, Forestomach                               (50)         (5)          (9)          (48)                                   
      Acanthosis                                       1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)       1 (20%)                   2 (4%)                                
   Stomach, Glandular                                 (50)         (4)          (9)          (48)                                   
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Necrosis, Coagulative                            1 (2%)       1 (25%)                                                         
   Tooth                                              (50)         (4)          (10)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (8)          (12)         (49)                                   
      Mesenteric Artery, Inflammation, Chronic                                                                                      
          Active                                                                              2 (4%)                                
   Heart                                              (50)         (7)          (10)         (50)                                   
      Cardiomyopathy, Chronic                         32 (64%)      2 (29%)      7 (70%)     44 (88%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Coronary Artery, Inflammation, Chronic Active    1 (2%)       1 (14%)                                                         
      Endocardium, Proliferation                                    1 (14%)                                                         
      Valve, Inflammation, Chronic Active              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Angiectasis                                      2 (4%)                    1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Degeneration, Fatty                              4 (8%)      10 (20%)      9 (18%)     11 (22%)                               
      Hyperplasia                                     13 (26%)     23 (46%)     18 (36%)     20 (40%)                               
      Hypertrophy                                      1 (2%)       2 (4%)                                                          
      Necrosis                                         3 (6%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      4 (8%)       4 (8%)       7 (14%)     24 (48%)                               
   Pituitary Gland                                    (50)         (33)         (35)         (50)                                   
      Pars Distalis, Angiectasis                       2 (4%)       1 (3%)                                                          
      Pars Distalis, Atypia Cellular                                             1 (3%)                                             
      Pars Distalis, Cyst                              2 (4%)       3 (9%)       7 (20%)     12 (24%)                               
      Pars Distalis, Degeneration, Cystic                                                     1 (2%)                                
      Pars Distalis, Hyperplasia                      17 (34%)     18 (55%)      9 (26%)     16 (32%)                               
      Pars Distalis, Inflammation, Chronic                                                    1 (2%)                                
      Pars Nervosa, Hyperplasia, Glandular                                                    2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (49)         (6)          (11)         (48)                                   
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic Active                                                            1 (2%)                                
      C-Cell, Hyperplasia                             25 (51%)      3 (50%)      2 (18%)     39 (81%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (5)          (11)         (48)                                   
      Hyperplasia                                      2 (4%)       1 (20%)      1 (9%)       5 (10%)                               
      Inflammation, Chronic Active                     8 (18%)      1 (20%)      1 (9%)       7 (15%)                               
      Duct, Dilatation                                                           1 (9%)                                             
   Ovary                                              (50)         (15)         (15)         (49)                                   
      Cyst                                             4 (8%)                    4 (27%)      4 (8%)                                
   Uterus                                             (50)         (14)         (20)         (50)                                   
      Dilatation                                       2 (4%)       2 (14%)      5 (25%)      6 (12%)                               
      Hemorrhage, Chronic                                                                     1 (2%)                                
      Inflammation, Chronic Active                                  1 (7%)       1 (5%)       1 (2%)                                
      Endometrium, Hyperplasia, Cystic, Glandular      9 (18%)      1 (7%)       3 (15%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (32)         (45)         (37)         (43)                                   
      Lymphopenia                                      1 (3%)                                                                       
      Neutropenia                                      1 (3%)                                                                       
      Neutrophilia                                     1 (3%)       2 (4%)                    3 (7%)                                
   Bone Marrow                                        (50)         (48)         (50)         (47)                                   
      Femoral, Atrophy                                 1 (2%)       1 (2%)                                                          
      Femoral, Hemorrhage, Acute                                    1 (2%)                                                          
      Femoral, Hyperplasia                            11 (22%)     12 (25%)     21 (42%)     37 (79%)                               
      Femoral, Hyperplasia, Re Cell                                                           4 (9%)                                
      Femoral, Hyperplasia, Reticulum Cell             1 (2%)       2 (4%)       7 (14%)      7 (15%)                               
   Lymph Node                                         (50)         (12)         (17)         (50)                                   
      Bronchial, Pigmentation, Hemosiderin                                                    1 (2%)                                
      Mediastinal, Cyst                                                                       2 (4%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          2 (4%)                                
      Mediastinal, Inflammation, Suppurative                                     1 (6%)                                             
      Mediastinal, Necrosis                            1 (2%)                                                                       
      Pancreatic, Pigmentation, Hemosiderin                                                   1 (2%)                                
      Renal, Cyst                                                                1 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Inflammation, Chronic Active                                        1 (6%)                                             
   Lymph Node, Mandibular                             (49)         (7)          (14)         (49)                                   
      Cyst                                                                                    2 (4%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Plasma Cell                         1 (2%)                                 1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (7)          (4)          (1)          (9)                                    
      Cyst                                                          1 (25%)      1 (100%)                                           
      Ectasia                                                       1 (25%)                                                         
      Edema                                            2 (29%)                   1 (100%)                                           
      Hemorrhage                                       1 (14%)                   1 (100%)                                           
      Hyperplasia, Lymphoid                                                                   1 (11%)                               
      Infiltration Cellular, Histiocyte                1 (14%)                                                                      
      Necrosis                                         1 (14%)                                                                      
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Depletion Lymphoid                               1 (2%)                                                                       
      Fibrosis                                         1 (2%)       2 (4%)       3 (6%)      42 (84%)                               
      Hematopoietic Cell Proliferation                41 (82%)     48 (96%)     48 (96%)     32 (64%)                               
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Lipocyte                                                        11 (22%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                       39 (78%)     49 (98%)     49 (98%)     48 (96%)                               
      Capsule, Cyst                                                                           3 (6%)                                
   Thymus                                             (42)         (8)          (11)         (44)                                   
      Depletion Lymphoid                               1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (17)         (22)         (50)                                   
      Hyperplasia, Cystic                             34 (69%)     11 (65%)     17 (77%)     48 (96%)                               
   Skin                                               (50)         (20)         (21)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Necrotizing                                                  1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (49)         (5)          (10)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (10)         (50)                                   
      Compression                                      4 (8%)       1 (20%)      4 (40%)      5 (10%)                               
      Hydrocephalus                                    3 (6%)       1 (20%)                   4 (8%)                                
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (5)          (11)         (50)                                   
      Granuloma                                                                               1 (2%)                                
      Hemorrhage, Acute                                1 (2%)                                                                       
      Inflammation, Chronic Active                     5 (10%)                                1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                 2 (4%)                                
      Mediastinum, Inflammation, Chronic Active        1 (2%)                    1 (9%)       1 (2%)                                
   Nose                                               (49)         (4)          (11)         (49)                                   
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Chronic Active                     3 (6%)                                11 (22%)                               
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                                              2 (4%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)                                 4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (12)         (32)         (31)         (31)                                   
      Inflammation, Chronic                            1 (8%)                    1 (3%)       1 (3%)                                
      Anterior Chamber, Inflammation, Suppurative                                             1 (3%)                                
      Cornea, Inflammation, Chronic                                 1 (3%)                                                          
      Lens, Cataract                                  10 (83%)     30 (94%)     30 (97%)     30 (97%)                               
      Retina, Atrophy                                 11 (92%)     32 (100%)    31 (100%)    31 (100%)                              
   Harderian Gland                                    (42)         (6)          (11)         (44)                                   
      Atrophy                                                                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 6 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Nephropathy, Chronic                            39 (78%)     39 (78%)     45 (90%)     41 (82%)                               
      Renal Tubule, Pigmentation, Hemosiderin         44 (88%)     48 (96%)     50 (100%)    50 (100%)                              
   Urinary Bladder                                    (50)         (5)          (8)          (49)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                                            1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          49           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                               5            5            9           17                                     
    Dosing Accident                                                              2            1                                     
    Moribund                                          26           13            7           11                                     
  Survivors                                                                                                                         
    Dead                                                                                      1                                     
    Terminal Sacrifice                                18           32           32           20                                     
  Animals Examined Microscopically                    49           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (5)          (13)         (50)                                   
      Foreign Body                                     1 (2%)                    2 (15%)      1 (2%)                                
      Inflammation, Necrotizing                                     1 (20%)      2 (15%)      1 (2%)                                
   Intestine Large, Cecum                             (46)         (5)          (6)          (44)                                   
      Dilatation                                                                              1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Parasite Metazoan                                                                       1 (2%)                                
   Intestine Large, Colon                             (46)         (5)          (9)          (45)                                   
      Parasite Metazoan                                1 (2%)                                 2 (4%)                                
   Intestine Large, Rectum                            (47)         (5)          (8)          (44)                                   
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Parasite Metazoan                                2 (4%)                    1 (13%)      4 (9%)                                
   Intestine Small, Ileum                             (46)         (5)          (6)          (39)                                   
      Dilatation                                                                              1 (3%)                                
      Inflammation, Chronic Active                                                            1 (3%)                                
   Intestine Small, Jejunum                           (46)         (6)          (8)          (41)                                   
      Dilatation                                                                              1 (2%)                                
      Metaplasia, Osseous                                           1 (17%)      1 (13%)                                            
      Necrosis                                                      1 (17%)                                                         
   Liver                                              (49)         (50)         (49)         (49)                                   
      Angiectasis                                                   1 (2%)       2 (4%)                                             
      Basophilic Focus                                14 (29%)     23 (46%)     31 (63%)     21 (43%)                               
      Clear Cell Focus                                                                        2 (4%)                                
      Degeneration, Cystic                            10 (20%)     16 (32%)     10 (20%)     12 (24%)                               
      Eosinophilic Focus                               3 (6%)                    1 (2%)       2 (4%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                                
      Hepatodiaphragmatic Nodule                       3 (6%)       8 (16%)      2 (4%)       2 (4%)                                
      Inflammation, Chronic                            8 (16%)     15 (30%)     19 (39%)      9 (18%)                               
      Inflammation, Necrotizing                        4 (8%)       2 (4%)       5 (10%)      4 (8%)                                
      Necrosis, Coagulative                            6 (12%)      4 (8%)       3 (6%)       9 (18%)                               
      Pigmentation, Hemosiderin                        1 (2%)                                26 (53%)                               
      Vacuolization Cytoplasmic                        6 (12%)      4 (8%)       9 (18%)      1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Bile Duct, Hyperplasia                          41 (84%)     45 (90%)     43 (88%)     47 (96%)                               
   Mesentery                                          (47)         (11)         (11)         (48)                                   
      Ectopic Tissue                                                                          1 (2%)                                
      Inflammation, Chronic                            6 (13%)      6 (55%)      2 (18%)      5 (10%)                               
      Necrosis                                         3 (6%)       4 (36%)                                                         
      Pigmentation, Hemosiderin                                                  1 (9%)       1 (2%)                                
   Pancreas                                           (48)         (8)          (14)         (47)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Pigmentation, Hemosiderin                                     1 (13%)      1 (7%)                                             
      Acinus, Atrophy                                 18 (38%)      3 (38%)      3 (21%)     13 (28%)                               
      Acinus, Hyperplasia                                                        1 (7%)       1 (2%)                                
      Duct, Ectasia                                    1 (2%)       1 (13%)                                                         
   Salivary Glands                                    (49)         (6)          (11)         (49)                                   
      Granuloma                                        1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (6)          (11)         (46)                                   
      Acanthosis                                       1 (2%)                    1 (9%)       1 (2%)                                
      Hyperkeratosis                                   1 (2%)                    1 (9%)       1 (2%)                                
      Inflammation, Chronic Active                     2 (4%)                    2 (18%)                                            
      Inflammation, Necrotizing                                     1 (17%)                                                         
   Stomach, Glandular                                 (48)         (6)          (11)         (45)                                   
      Inflammation, Chronic Active                     1 (2%)                    1 (9%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)       2 (33%)                   4 (9%)                                
   Tongue                                             (2)          (1)                       (1)                                    
      Foreign Body                                     2 (100%)                               1 (100%)                              
      Inflammation, Chronic Active                     2 (100%)     1 (100%)                  1 (100%)                              
   Tooth                                              (49)         (5)          (10)         (49)                                   
      Peridontal Tissue, Foreign Body                                                         1 (2%)                                
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                       2 (4%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (8)          (12)         (50)                                   
      Mesenteric Artery, Inflammation, Chronic                                                                                      
          Active                                                                              1 (2%)                                
      Mesenteric Artery, Necrosis, Fibrinoid                                                  1 (2%)                                
      Mesenteric Artery, Intima, Proliferation         1 (2%)                                                                       
      Pulmonary Artery, Thrombosis                                  1 (13%)                                                         
   Heart                                              (49)         (18)         (23)         (50)                                   
      Cardiomyopathy, Chronic                         44 (90%)     15 (83%)     22 (96%)     42 (84%)                               
      Mineralization                                                                          1 (2%)                                
      Atrium, Thrombosis                               5 (10%)      1 (6%)                    8 (16%)                               
      Endocardium, Proliferation                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (49)         (49)                                   
      Degeneration, Fatty                             10 (20%)     11 (22%)     10 (20%)     16 (33%)                               
      Hematocyst                                                                              1 (2%)                                
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                     17 (35%)     13 (26%)     19 (39%)     17 (35%)                               
      Hypertrophy                                      1 (2%)       1 (2%)                                                          
      Necrosis, Coagulative                            2 (4%)       1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (49)         (48)         (48)                                   
      Cyst                                                                       1 (2%)                                             
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                     15 (31%)     22 (45%)     15 (31%)     17 (35%)                               
      Mineralization                                   1 (2%)                                                                       
   Islets, Pancreatic                                 (48)         (4)          (10)         (46)                                   
      Degeneration                                     1 (2%)                                                                       
   Parathyroid Gland                                  (48)         (7)          (10)         (45)                                   
      Hyperplasia                                                   1 (14%)                                                         
   Pituitary Gland                                    (47)         (18)         (19)         (46)                                   
      Craniopharyngeal Duct, Cyst                                                             1 (2%)                                
      Pars Distalis, Angiectasis                                    1 (6%)       1 (5%)                                             
      Pars Distalis, Cyst                              3 (6%)                                 1 (2%)                                
      Pars Distalis, Hemorrhage, Acute                                           1 (5%)                                             
      Pars Distalis, Hyperplasia                      11 (23%)      2 (11%)      2 (11%)     13 (28%)                               
      Pars Distalis, Pigmentation, Hemosiderin                      1 (6%)                                                          
      Pars Intermedia, Angiectasis                                  1 (6%)                                                          
   Thyroid Gland                                      (48)         (8)          (10)         (45)                                   
      Inflammation, Necrotizing                                                               1 (2%)                                
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                             19 (40%)      4 (50%)      4 (40%)     24 (53%)                               
      Follicular Cell, Hyperplasia                                                            2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (20)         (26)         (50)                                   
      Atrophy, Diffuse                                 1 (2%)                                                                       
   Penis                                                                        (1)                                                 
      Concretion                                                                 1 (100%)                                           
   Preputial Gland                                    (46)         (12)         (15)         (48)                                   
      Hyperplasia                                      2 (4%)                    1 (7%)       3 (6%)                                
      Inflammation, Chronic Active                    45 (98%)      6 (50%)      7 (47%)     43 (90%)                               
   Prostate                                           (49)         (6)          (13)         (48)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Abscess                                                                                 1 (2%)                                
      Inflammation, Chronic Active                    32 (65%)      4 (67%)     11 (85%)     29 (60%)                               
   Seminal Vesicle                                    (36)         (3)          (5)          (23)                                   
      Inflammation, Chronic Active                     3 (8%)                                                                       
   Testes                                             (49)         (46)         (50)         (50)                                   
      Interstitial Cell, Hyperplasia                  26 (53%)     29 (63%)     23 (46%)     25 (50%)                               
      Seminiferous Tubule, Atrophy                    33 (67%)     44 (96%)     39 (78%)     46 (92%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (44)         (45)         (39)         (31)                                   
      Leukocytosis                                     1 (2%)                                                                       
      Neutrophilia                                                  2 (4%)       1 (3%)       6 (19%)                               
   Bone Marrow                                        (49)         (50)         (49)         (50)                                   
      Hyperplasia                                                                1 (2%)       2 (4%)                                
      Thrombosis                                                                              1 (2%)                                
      Femoral, Hyperplasia                            26 (53%)     36 (72%)     35 (71%)     46 (92%)                               
      Femoral, Hyperplasia, Reticulum Cell                                       3 (6%)                                             
      Femoral, Myelofibrosis                           1 (2%)                                                                       
   Lymph Node                                         (49)         (16)         (15)         (49)                                   
      Mediastinal, Cyst                                                                       2 (4%)                                
      Mediastinal, Edema                                                                      1 (2%)                                
      Mediastinal, Hemorrhage, Acute                                                          1 (2%)                                
      Mediastinal, Hyperplasia, Plasma Cell                         1 (6%)                                                          
      Mediastinal, Infiltration Cellular, Mast Cell                              1 (7%)       1 (2%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          1 (2%)                                
      Mediastinal, Pigmentation, Hemosiderin                                                  2 (4%)                                
      Pancreatic, Ectopic Tissue                                                              1 (2%)                                
      Pancreatic, Infiltration Cellular, Histiocyte                                           2 (4%)                                
      Pancreatic, Pigmentation, Hemosiderin                                                   2 (4%)                                
      Renal, Cyst                                                   1 (6%)                    1 (2%)                                
   Lymph Node, Mandibular                             (48)         (7)          (12)         (48)                                   
      Cyst                                             4 (8%)                                 4 (8%)                                
      Ectasia                                                       1 (14%)      1 (8%)                                             
   Lymph Node, Mesenteric                             (10)         (5)          (2)          (10)                                   
      Cyst                                             2 (20%)      2 (40%)      1 (50%)      2 (20%)                               
      Ectasia                                                                    1 (50%)                                            
      Fibrosis                                                      1 (20%)                                                         
      Infiltration Cellular, Histiocyte                             1 (20%)                   1 (10%)                               
      Pigmentation, Hemosiderin                                                               1 (10%)                               
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Fibrosis                                         3 (6%)      11 (22%)     12 (24%)     41 (82%)                               
      Granuloma                                                                               1 (2%)                                
      Hematopoietic Cell Proliferation                31 (63%)     48 (96%)     42 (84%)     26 (52%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infarct, Acute                                   1 (2%)                                 1 (2%)                                
      Infiltration Cellular, Lipocyte                                                        24 (48%)                               
      Pigmentation, Hemosiderin                       37 (76%)     39 (78%)     48 (96%)     21 (42%)                               
      Sinusoid, Ectasia                                                                       1 (2%)                                
   Thymus                                             (43)         (5)          (13)         (36)                                   
      Cyst                                             1 (2%)                                 1 (3%)                                
      Inflammation, Chronic Active                                                            1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (32)         (6)          (13)         (36)                                   
      Hyperplasia, Cystic                             25 (78%)      6 (100%)    10 (77%)     29 (81%)                               
   Skin                                               (47)         (18)         (19)         (49)                                   
      Inflammation, Chronic Active                     1 (2%)                    1 (5%)                                             
      Inflammation, Necrotizing                                     1 (6%)                                                          
      Inflammation, Suppurative                                     1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (48)         (50)         (49)         (50)                                   
      Femur, Fibrous Osteodystrophy                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (5)          (10)         (50)                                   
      Compression                                      4 (8%)                    2 (20%)      1 (2%)                                
      Hemorrhage, Acute                                1 (2%)                    1 (10%)                                            
      Hydrocephalus                                    5 (10%)      1 (20%)      1 (10%)      2 (4%)                                
      Infarct, Chronic                                 1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
   Spinal Cord                                        (4)                       (2)          (1)                                    
      Degeneration                                     1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (7)          (11)         (50)                                   
      Granuloma                                                                               1 (2%)                                
      Hemorrhage, Acute                                3 (6%)                                                                       
      Inflammation, Chronic                            2 (4%)       1 (14%)                   4 (8%)                                
      Inflammation, Suppurative                                                               2 (4%)                                
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (6%)                                 2 (4%)                                
      Mediastinum, Inflammation, Chronic Active                     1 (14%)                   1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:57  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (48)         (5)          (10)         (46)                                   
      Inflammation, Chronic Active                     6 (13%)                                8 (17%)                               
      Inflammation, Suppurative                                     1 (20%)                   1 (2%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                                              1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     4 (8%)                    1 (10%)      3 (7%)                                
      Septum, Thrombosis, Multiple                     1 (2%)                                                                       
   Trachea                                            (49)         (5)          (13)         (49)                                   
      Inflammation, Necrotizing                                                  2 (15%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (7)          (11)         (13)         (14)                                   
      Hemorrhage, Acute                                             1 (9%)                                                          
      Inflammation, Chronic                                                                   1 (7%)                                
      Cornea, Inflammation, Chronic Active                          1 (9%)                                                          
      Lens, Cataract                                   4 (57%)     11 (100%)    12 (92%)     13 (93%)                               
      Retina, Atrophy                                  5 (71%)     11 (100%)    13 (100%)    13 (93%)                               
   Harderian Gland                                    (46)         (4)          (9)          (43)                                   
      Inflammation, Chronic                                                                   3 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (50)         (49)         (50)                                   
      Inflammation, Hemorrhagic                                     1 (2%)                                                          
      Nephropathy, Chronic                            46 (96%)     50 (100%)    48 (98%)     46 (92%)                               
      Renal Tubule, Degeneration                                    1 (2%)                                                          
      Renal Tubule, Pigmentation, Hemosiderin         47 (98%)     49 (98%)     47 (96%)     50 (100%)                              
   Urethra                                            (21)         (3)          (1)          (11)                                   
      Inflammation, Hemorrhagic                                     1 (33%)                                                         
      Transitional Epithelium, Hyperplasia                                       1 (100%)                                           
   Urinary Bladder                                    (47)         (7)          (12)         (46)                                   
      Dilatation                                                    1 (14%)                   1 (2%)                                
      Hemorrhage, Acute                                1 (2%)                                                                       
      Inflammation, Chronic Active                                                            2 (4%)                                
      Inflammation, Hemorrhagic                                     1 (14%)                                                         
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.