TR 351 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
PARA-CHLOROANILINE
NTP Experiment-Test: 05020-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 18:08:57
Facility: Battelle Columbus Laboratory
Chemical CAS #: 000106478
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Dead 15 5 11 8
Moribund 8 6 3 5
Survivors
Terminal Sacrifice 27 39 36 37
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (8) (12) (50)
Foreign Body 6 (12%) 1 (13%) 3 (25%)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Cecum (40) (4) (3) (46)
Inflammation, Chronic Active 1 (25%)
Parasite Metazoan 1 (3%) 1 (25%) 1 (2%)
Intestine Large, Colon (47) (6) (8) (46)
Inflammation, Chronic Active 1 (2%)
Inflammation, Necrotizing 1 (13%)
Parasite Metazoan 4 (9%) 1 (13%) 3 (7%)
Intestine Large, Rectum (45) (3) (6) (47)
Parasite Metazoan 3 (7%) 1 (17%) 2 (4%)
Liver (50) (50) (50) (50)
Basophilic Focus 38 (76%) 45 (90%) 46 (92%) 44 (88%)
Clear Cell Focus 1 (2%) 3 (6%)
Degeneration, Cystic 1 (2%)
Degeneration, Fatty 1 (2%)
Fibrosis 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%) 2 (4%) 2 (4%) 3 (6%)
Inflammation, Chronic 32 (64%) 30 (60%) 32 (64%) 36 (72%)
Inflammation, Necrotizing 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Necrosis, Coagulative 2 (4%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Vacuolization Cytoplasmic 3 (6%) 3 (6%) 1 (2%)
Bile Duct, Hyperplasia 8 (16%) 3 (6%) 1 (2%) 9 (18%)
Portal Vein, Intima, Proliferation 1 (2%)
Mesentery (49) (7) (11) (47)
Inflammation, Chronic 2 (29%) 2 (18%) 8 (17%)
Necrosis 2 (29%) 1 (2%)
Pancreas (50) (6) (12) (49)
Ectopic Tissue 1 (2%)
Inflammation, Chronic 2 (17%) 2 (4%)
Acinus, Atrophy 13 (26%) 1 (17%) 3 (25%) 15 (31%)
Pharynx (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (100%)
Salivary Glands (50) (8) (12) (49)
Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (5) (9) (48)
Acanthosis 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (20%) 2 (4%)
Stomach, Glandular (50) (4) (9) (48)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (25%)
Tooth (50) (4) (10) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (8) (12) (49)
Mesenteric Artery, Inflammation, Chronic
Active 2 (4%)
Heart (50) (7) (10) (50)
Cardiomyopathy, Chronic 32 (64%) 2 (29%) 7 (70%) 44 (88%)
Inflammation, Chronic Active 1 (2%)
Coronary Artery, Inflammation, Chronic Active 1 (2%) 1 (14%)
Endocardium, Proliferation 1 (14%)
Valve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 2 (4%) 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 4 (8%) 10 (20%) 9 (18%) 11 (22%)
Hyperplasia 13 (26%) 23 (46%) 18 (36%) 20 (40%)
Hypertrophy 1 (2%) 2 (4%)
Necrosis 3 (6%)
Adrenal Gland, Medulla (50) (50) (50) (50)
Hyperplasia 4 (8%) 4 (8%) 7 (14%) 24 (48%)
Pituitary Gland (50) (33) (35) (50)
Pars Distalis, Angiectasis 2 (4%) 1 (3%)
Pars Distalis, Atypia Cellular 1 (3%)
Pars Distalis, Cyst 2 (4%) 3 (9%) 7 (20%) 12 (24%)
Pars Distalis, Degeneration, Cystic 1 (2%)
Pars Distalis, Hyperplasia 17 (34%) 18 (55%) 9 (26%) 16 (32%)
Pars Distalis, Inflammation, Chronic 1 (2%)
Pars Nervosa, Hyperplasia, Glandular 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (49) (6) (11) (48)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
C-Cell, Hyperplasia 25 (51%) 3 (50%) 2 (18%) 39 (81%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (5) (11) (48)
Hyperplasia 2 (4%) 1 (20%) 1 (9%) 5 (10%)
Inflammation, Chronic Active 8 (18%) 1 (20%) 1 (9%) 7 (15%)
Duct, Dilatation 1 (9%)
Ovary (50) (15) (15) (49)
Cyst 4 (8%) 4 (27%) 4 (8%)
Uterus (50) (14) (20) (50)
Dilatation 2 (4%) 2 (14%) 5 (25%) 6 (12%)
Hemorrhage, Chronic 1 (2%)
Inflammation, Chronic Active 1 (7%) 1 (5%) 1 (2%)
Endometrium, Hyperplasia, Cystic, Glandular 9 (18%) 1 (7%) 3 (15%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (32) (45) (37) (43)
Lymphopenia 1 (3%)
Neutropenia 1 (3%)
Neutrophilia 1 (3%) 2 (4%) 3 (7%)
Bone Marrow (50) (48) (50) (47)
Femoral, Atrophy 1 (2%) 1 (2%)
Femoral, Hemorrhage, Acute 1 (2%)
Femoral, Hyperplasia 11 (22%) 12 (25%) 21 (42%) 37 (79%)
Femoral, Hyperplasia, Re Cell 4 (9%)
Femoral, Hyperplasia, Reticulum Cell 1 (2%) 2 (4%) 7 (14%) 7 (15%)
Lymph Node (50) (12) (17) (50)
Bronchial, Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Cyst 2 (4%)
Mediastinal, Infiltration Cellular,
Histiocyte 2 (4%)
Mediastinal, Inflammation, Suppurative 1 (6%)
Mediastinal, Necrosis 1 (2%)
Pancreatic, Pigmentation, Hemosiderin 1 (2%)
Renal, Cyst 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Inflammation, Chronic Active 1 (6%)
Lymph Node, Mandibular (49) (7) (14) (49)
Cyst 2 (4%)
Hemorrhage 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mesenteric (7) (4) (1) (9)
Cyst 1 (25%) 1 (100%)
Ectasia 1 (25%)
Edema 2 (29%) 1 (100%)
Hemorrhage 1 (14%) 1 (100%)
Hyperplasia, Lymphoid 1 (11%)
Infiltration Cellular, Histiocyte 1 (14%)
Necrosis 1 (14%)
Spleen (50) (50) (50) (50)
Cyst 1 (2%)
Depletion Lymphoid 1 (2%)
Fibrosis 1 (2%) 2 (4%) 3 (6%) 42 (84%)
Hematopoietic Cell Proliferation 41 (82%) 48 (96%) 48 (96%) 32 (64%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Lipocyte 11 (22%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 39 (78%) 49 (98%) 49 (98%) 48 (96%)
Capsule, Cyst 3 (6%)
Thymus (42) (8) (11) (44)
Depletion Lymphoid 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (17) (22) (50)
Hyperplasia, Cystic 34 (69%) 11 (65%) 17 (77%) 48 (96%)
Skin (50) (20) (21) (50)
Inflammation, Chronic Active 1 (2%)
Inflammation, Necrotizing 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (49) (5) (10) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (5) (10) (50)
Compression 4 (8%) 1 (20%) 4 (40%) 5 (10%)
Hydrocephalus 3 (6%) 1 (20%) 4 (8%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (5) (11) (50)
Granuloma 1 (2%)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 5 (10%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Mediastinum, Inflammation, Chronic Active 1 (2%) 1 (9%) 1 (2%)
Nose (49) (4) (11) (49)
Foreign Body 1 (2%)
Inflammation, Chronic Active 3 (6%) 11 (22%)
Nasolacrimal Duct, Inflammation, Chronic
Active 2 (4%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (12) (32) (31) (31)
Inflammation, Chronic 1 (8%) 1 (3%) 1 (3%)
Anterior Chamber, Inflammation, Suppurative 1 (3%)
Cornea, Inflammation, Chronic 1 (3%)
Lens, Cataract 10 (83%) 30 (94%) 30 (97%) 30 (97%)
Retina, Atrophy 11 (92%) 32 (100%) 31 (100%) 31 (100%)
Harderian Gland (42) (6) (11) (44)
Atrophy 1 (2%)
Inflammation, Chronic 1 (2%) 6 (14%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
Nephropathy, Chronic 39 (78%) 39 (78%) 45 (90%) 41 (82%)
Renal Tubule, Pigmentation, Hemosiderin 44 (88%) 48 (96%) 50 (100%) 50 (100%)
Urinary Bladder (50) (5) (8) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 49 50 50 50
Early Deaths
Dead 5 5 9 17
Dosing Accident 2 1
Moribund 26 13 7 11
Survivors
Dead 1
Terminal Sacrifice 18 32 32 20
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (5) (13) (50)
Foreign Body 1 (2%) 2 (15%) 1 (2%)
Inflammation, Necrotizing 1 (20%) 2 (15%) 1 (2%)
Intestine Large, Cecum (46) (5) (6) (44)
Dilatation 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (46) (5) (9) (45)
Parasite Metazoan 1 (2%) 2 (4%)
Intestine Large, Rectum (47) (5) (8) (44)
Inflammation, Chronic Active 2 (4%)
Parasite Metazoan 2 (4%) 1 (13%) 4 (9%)
Intestine Small, Ileum (46) (5) (6) (39)
Dilatation 1 (3%)
Inflammation, Chronic Active 1 (3%)
Intestine Small, Jejunum (46) (6) (8) (41)
Dilatation 1 (2%)
Metaplasia, Osseous 1 (17%) 1 (13%)
Necrosis 1 (17%)
Liver (49) (50) (49) (49)
Angiectasis 1 (2%) 2 (4%)
Basophilic Focus 14 (29%) 23 (46%) 31 (63%) 21 (43%)
Clear Cell Focus 2 (4%)
Degeneration, Cystic 10 (20%) 16 (32%) 10 (20%) 12 (24%)
Eosinophilic Focus 3 (6%) 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 8 (16%) 2 (4%) 2 (4%)
Inflammation, Chronic 8 (16%) 15 (30%) 19 (39%) 9 (18%)
Inflammation, Necrotizing 4 (8%) 2 (4%) 5 (10%) 4 (8%)
Necrosis, Coagulative 6 (12%) 4 (8%) 3 (6%) 9 (18%)
Pigmentation, Hemosiderin 1 (2%) 26 (53%)
Vacuolization Cytoplasmic 6 (12%) 4 (8%) 9 (18%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 41 (84%) 45 (90%) 43 (88%) 47 (96%)
Mesentery (47) (11) (11) (48)
Ectopic Tissue 1 (2%)
Inflammation, Chronic 6 (13%) 6 (55%) 2 (18%) 5 (10%)
Necrosis 3 (6%) 4 (36%)
Pigmentation, Hemosiderin 1 (9%) 1 (2%)
Pancreas (48) (8) (14) (47)
Inflammation, Chronic 1 (2%)
Pigmentation, Hemosiderin 1 (13%) 1 (7%)
Acinus, Atrophy 18 (38%) 3 (38%) 3 (21%) 13 (28%)
Acinus, Hyperplasia 1 (7%) 1 (2%)
Duct, Ectasia 1 (2%) 1 (13%)
Salivary Glands (49) (6) (11) (49)
Granuloma 1 (2%)
Stomach, Forestomach (47) (6) (11) (46)
Acanthosis 1 (2%) 1 (9%) 1 (2%)
Hyperkeratosis 1 (2%) 1 (9%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (18%)
Inflammation, Necrotizing 1 (17%)
Stomach, Glandular (48) (6) (11) (45)
Inflammation, Chronic Active 1 (2%) 1 (9%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%) 2 (33%) 4 (9%)
Tongue (2) (1) (1)
Foreign Body 2 (100%) 1 (100%)
Inflammation, Chronic Active 2 (100%) 1 (100%) 1 (100%)
Tooth (49) (5) (10) (49)
Peridontal Tissue, Foreign Body 1 (2%)
Peridontal Tissue, Inflammation, Chronic
Active 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (8) (12) (50)
Mesenteric Artery, Inflammation, Chronic
Active 1 (2%)
Mesenteric Artery, Necrosis, Fibrinoid 1 (2%)
Mesenteric Artery, Intima, Proliferation 1 (2%)
Pulmonary Artery, Thrombosis 1 (13%)
Heart (49) (18) (23) (50)
Cardiomyopathy, Chronic 44 (90%) 15 (83%) 22 (96%) 42 (84%)
Mineralization 1 (2%)
Atrium, Thrombosis 5 (10%) 1 (6%) 8 (16%)
Endocardium, Proliferation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (49) (49)
Degeneration, Fatty 10 (20%) 11 (22%) 10 (20%) 16 (33%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 17 (35%) 13 (26%) 19 (39%) 17 (35%)
Hypertrophy 1 (2%) 1 (2%)
Necrosis, Coagulative 2 (4%) 1 (2%) 1 (2%)
Adrenal Gland, Medulla (49) (49) (48) (48)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 15 (31%) 22 (45%) 15 (31%) 17 (35%)
Mineralization 1 (2%)
Islets, Pancreatic (48) (4) (10) (46)
Degeneration 1 (2%)
Parathyroid Gland (48) (7) (10) (45)
Hyperplasia 1 (14%)
Pituitary Gland (47) (18) (19) (46)
Craniopharyngeal Duct, Cyst 1 (2%)
Pars Distalis, Angiectasis 1 (6%) 1 (5%)
Pars Distalis, Cyst 3 (6%) 1 (2%)
Pars Distalis, Hemorrhage, Acute 1 (5%)
Pars Distalis, Hyperplasia 11 (23%) 2 (11%) 2 (11%) 13 (28%)
Pars Distalis, Pigmentation, Hemosiderin 1 (6%)
Pars Intermedia, Angiectasis 1 (6%)
Thyroid Gland (48) (8) (10) (45)
Inflammation, Necrotizing 1 (2%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 19 (40%) 4 (50%) 4 (40%) 24 (53%)
Follicular Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (20) (26) (50)
Atrophy, Diffuse 1 (2%)
Penis (1)
Concretion 1 (100%)
Preputial Gland (46) (12) (15) (48)
Hyperplasia 2 (4%) 1 (7%) 3 (6%)
Inflammation, Chronic Active 45 (98%) 6 (50%) 7 (47%) 43 (90%)
Prostate (49) (6) (13) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Abscess 1 (2%)
Inflammation, Chronic Active 32 (65%) 4 (67%) 11 (85%) 29 (60%)
Seminal Vesicle (36) (3) (5) (23)
Inflammation, Chronic Active 3 (8%)
Testes (49) (46) (50) (50)
Interstitial Cell, Hyperplasia 26 (53%) 29 (63%) 23 (46%) 25 (50%)
Seminiferous Tubule, Atrophy 33 (67%) 44 (96%) 39 (78%) 46 (92%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (44) (45) (39) (31)
Leukocytosis 1 (2%)
Neutrophilia 2 (4%) 1 (3%) 6 (19%)
Bone Marrow (49) (50) (49) (50)
Hyperplasia 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Femoral, Hyperplasia 26 (53%) 36 (72%) 35 (71%) 46 (92%)
Femoral, Hyperplasia, Reticulum Cell 3 (6%)
Femoral, Myelofibrosis 1 (2%)
Lymph Node (49) (16) (15) (49)
Mediastinal, Cyst 2 (4%)
Mediastinal, Edema 1 (2%)
Mediastinal, Hemorrhage, Acute 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (6%)
Mediastinal, Infiltration Cellular, Mast Cell 1 (7%) 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Mediastinal, Pigmentation, Hemosiderin 2 (4%)
Pancreatic, Ectopic Tissue 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 2 (4%)
Pancreatic, Pigmentation, Hemosiderin 2 (4%)
Renal, Cyst 1 (6%) 1 (2%)
Lymph Node, Mandibular (48) (7) (12) (48)
Cyst 4 (8%) 4 (8%)
Ectasia 1 (14%) 1 (8%)
Lymph Node, Mesenteric (10) (5) (2) (10)
Cyst 2 (20%) 2 (40%) 1 (50%) 2 (20%)
Ectasia 1 (50%)
Fibrosis 1 (20%)
Infiltration Cellular, Histiocyte 1 (20%) 1 (10%)
Pigmentation, Hemosiderin 1 (10%)
Spleen (49) (50) (50) (50)
Cyst 1 (2%)
Fibrosis 3 (6%) 11 (22%) 12 (24%) 41 (82%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 31 (63%) 48 (96%) 42 (84%) 26 (52%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infarct, Acute 1 (2%) 1 (2%)
Infiltration Cellular, Lipocyte 24 (48%)
Pigmentation, Hemosiderin 37 (76%) 39 (78%) 48 (96%) 21 (42%)
Sinusoid, Ectasia 1 (2%)
Thymus (43) (5) (13) (36)
Cyst 1 (2%) 1 (3%)
Inflammation, Chronic Active 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (32) (6) (13) (36)
Hyperplasia, Cystic 25 (78%) 6 (100%) 10 (77%) 29 (81%)
Skin (47) (18) (19) (49)
Inflammation, Chronic Active 1 (2%) 1 (5%)
Inflammation, Necrotizing 1 (6%)
Inflammation, Suppurative 1 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (48) (50) (49) (50)
Femur, Fibrous Osteodystrophy 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (5) (10) (50)
Compression 4 (8%) 2 (20%) 1 (2%)
Hemorrhage, Acute 1 (2%) 1 (10%)
Hydrocephalus 5 (10%) 1 (20%) 1 (10%) 2 (4%)
Infarct, Chronic 1 (2%)
Mineralization 1 (2%)
Spinal Cord (4) (2) (1)
Degeneration 1 (25%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (7) (11) (50)
Granuloma 1 (2%)
Hemorrhage, Acute 3 (6%)
Inflammation, Chronic 2 (4%) 1 (14%) 4 (8%)
Inflammation, Suppurative 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%)
Mediastinum, Inflammation, Chronic Active 1 (14%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PARA-CHLOROANILINE Date: 09/03/94
Route: GAVAGE Time: 18:08:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 2 MG/KG 6 MG/KG 18 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (48) (5) (10) (46)
Inflammation, Chronic Active 6 (13%) 8 (17%)
Inflammation, Suppurative 1 (20%) 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 1 (10%) 3 (7%)
Septum, Thrombosis, Multiple 1 (2%)
Trachea (49) (5) (13) (49)
Inflammation, Necrotizing 2 (15%) 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (7) (11) (13) (14)
Hemorrhage, Acute 1 (9%)
Inflammation, Chronic 1 (7%)
Cornea, Inflammation, Chronic Active 1 (9%)
Lens, Cataract 4 (57%) 11 (100%) 12 (92%) 13 (93%)
Retina, Atrophy 5 (71%) 11 (100%) 13 (100%) 13 (93%)
Harderian Gland (46) (4) (9) (43)
Inflammation, Chronic 3 (7%)
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URINARY SYSTEM
Kidney (48) (50) (49) (50)
Inflammation, Hemorrhagic 1 (2%)
Nephropathy, Chronic 46 (96%) 50 (100%) 48 (98%) 46 (92%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin 47 (98%) 49 (98%) 47 (96%) 50 (100%)
Urethra (21) (3) (1) (11)
Inflammation, Hemorrhagic 1 (33%)
Transitional Epithelium, Hyperplasia 1 (100%)
Urinary Bladder (47) (7) (12) (46)
Dilatation 1 (14%) 1 (2%)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 2 (4%)
Inflammation, Hemorrhagic 1 (14%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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