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TR 354 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            DIMETHOXANE


NTP Experiment-Test: 05038-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 09:04:25




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  828-00-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           7            5            9                                                  
    Dead                                               7            9            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           35           34                                                  
  Missing                                                           1                                                               
  Animals Examined Microscopically                    50           49           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (6)          (45)                                                
      Cyst                                             1 (2%)                                                                       
   Intestine Large, Colon                             (48)         (12)         (48)                                                
      Parasite Metazoan                                                          2 (4%)                                             
   Intestine Small, Duodenum                          (46)         (8)          (45)                                                
      Amyloid Deposition                                            1 (13%)                                                         
   Intestine Small, Jejunum                           (48)         (13)         (45)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Liver                                              (50)         (19)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                                           1 (2%)                                             
      Hematopoietic Cell Proliferation                11 (22%)      1 (5%)      11 (22%)                                            
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic                            3 (6%)                                                                       
      Inflammation, Necrotizing                                                  2 (4%)                                             
      Leukocytosis                                     2 (4%)                    2 (4%)                                             
      Necrosis, Coagulative                            2 (4%)       1 (5%)       2 (4%)                                             
      Pigmentation, Hemosiderin                        3 (6%)                                                                       
   Mesentery                                          (41)         (11)         (49)                                                
      Inflammation, Chronic Active                     4 (10%)      2 (18%)      2 (4%)                                             
      Necrosis, Coagulative                                                      1 (2%)                                             
   Pancreas                                           (49)         (15)         (49)                                                
      Cyst                                                          1 (7%)                                                          
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)                                                                       
      Acinus, Atrophy                                  3 (6%)       1 (7%)       1 (2%)                                             
   Salivary Glands                                    (48)         (13)         (49)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (48)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acanthosis                                                    5 (10%)     23 (48%)                                            
      Hyperkeratosis                                                4 (8%)      27 (56%)                                            
      Hyperplasia, Focal                               3 (6%)      14 (29%)     22 (46%)                                            
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                                  4 (8%)       6 (13%)                                            
      Ulcer                                            1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (12)         (48)                                                
      Cyst                                             1 (2%)                    4 (8%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Tooth                                              (50)         (14)         (50)                                                
      Dysplasia                                                                  3 (6%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (14)         (50)                                                
      Cardiomyopathy, Chronic                          1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis, Fibrinoid                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (14)         (50)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Cyst                                                                       2 (4%)                                             
      Degeneration, Fatty                              1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hypertrophy                                                                2 (4%)                                             
      Necrosis, Coagulative                                         1 (7%)                                                          
   Adrenal Gland, Medulla                             (49)         (14)         (50)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                      3 (6%)                    1 (2%)                                             
   Islets, Pancreatic                                 (49)         (13)         (49)                                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (47)         (19)         (45)                                                
      Pars Distalis, Cyst                              2 (4%)                                                                       
      Pars Distalis, Hyperplasia                      14 (30%)      3 (16%)     18 (40%)                                            
   Thyroid Gland                                      (50)         (14)         (47)                                                
      Follicle, Cyst                                                1 (7%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                     9 (18%)                   2 (4%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (21)         (50)                                                
      Atrophy                                          6 (12%)      2 (10%)      3 (6%)                                             
      Cyst                                            18 (37%)      9 (43%)     21 (42%)                                            
      Inflammation, Chronic Active                     5 (10%)                   1 (2%)                                             
      Mineralization                                   3 (6%)                    1 (2%)                                             
   Uterus                                             (50)         (43)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Bacterium                                        1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                        6 (12%)      4 (9%)       5 (10%)                                            
      Thrombosis                                                    1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic, Glandular     40 (80%)     40 (93%)     45 (90%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (14)         (50)                                                
      Femoral, Hyperplasia                             4 (8%)                    3 (6%)                                             
      Femoral, Myelofibrosis                           2 (4%)                    2 (4%)                                             
   Lymph Node                                         (50)         (16)         (50)                                                
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Inflammation, Suppurative           1 (2%)                                                                       
      Mediastinal, Pigmentation, Hemosiderin                                     1 (2%)                                             
      Mesenteric, Angiectasis                          1 (2%)       2 (13%)                                                         
      Mesenteric, Cyst                                 1 (2%)                                                                       
      Mesenteric, Hematopoietic Cell Proliferation     1 (2%)       2 (13%)                                                         
   Lymph Node, Mandibular                             (48)         (13)         (49)                                                
      Pigmentation, Hemosiderin                        6 (13%)                   4 (8%)                                             
   Spleen                                             (50)         (23)         (50)                                                
      Hematopoietic Cell Proliferation                26 (52%)      6 (26%)     23 (46%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
      Necrosis, Coagulative                                                      1 (2%)                                             
   Thymus                                             (31)         (9)          (31)                                                
      Necrosis                                         1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (10)         (40)                                                
      Hyperplasia, Cystic                             17 (39%)                  28 (70%)                                            
   Skin                                               (50)         (14)         (49)                                                
      Fibrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (14)         (50)                                                
      Joint, Tarsal, Metaplasia, Osseous               2 (4%)                                                                       
   Skeletal Muscle                                    (50)         (13)         (50)                                                
      Fibrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (14)         (50)                                                
      Compression                                      1 (2%)                    1 (2%)                                             
      Hydrocephalus                                                              1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (14)         (50)                                                
      Edema                                                         1 (7%)                                                          
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Infiltration Cellular, Lymphocyte                                          2 (4%)                                             
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                             
      Leukocytosis                                     1 (2%)                    3 (6%)                                             
      Alveolar Epithelium, Hyperplasia                              1 (7%)       1 (2%)                                             
   Nose                                               (50)         (14)         (50)                                                
      Nasolacrimal Duct, Inflammation, Suppurative                               2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (3)                                                 
      Lens, Cataract                                                             1 (33%)                                            
      Retina, Atrophy                                                            1 (33%)                                            
   Harderian Gland                                    (48)         (11)         (50)                                                
      Hyperplasia                                      3 (6%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Glomerulosclerosis                               1 (2%)       1 (7%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infarct, Chronic                                 2 (4%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Nephropathy, Chronic                             4 (8%)                    6 (12%)                                            
   Urinary Bladder                                    (49)         (12)         (49)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           6           11            9                                                  
    Dead                                              11           10           12                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           27           29                                                  
  Wrong Sex                                                         2                                                               
  Animals Examined Microscopically                    50           48           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (15)         (45)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Large, Colon                             (47)         (19)         (47)                                                
      Parasite Metazoan                                1 (2%)       1 (5%)       2 (4%)                                             
   Intestine Large, Rectum                            (45)         (16)         (44)                                                
      Inflammation, Necrotizing                                                  1 (2%)                                             
   Intestine Small, Duodenum                          (44)         (18)         (43)                                                
      Inflammation, Necrotizing                                     1 (6%)       1 (2%)                                             
   Intestine Small, Ileum                             (44)         (16)         (44)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (47)         (19)         (44)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (49)         (28)         (50)                                                
      Cyst                                                          1 (4%)                                                          
      Degeneration, Fatty                                                        1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)                    8 (16%)                                            
      Hepatodiaphragmatic Nodule                       1 (2%)                                                                       
      Infarct                                                       1 (4%)                                                          
      Inflammation, Chronic                                         1 (4%)                                                          
      Inflammation, Necrotizing                                     2 (7%)       1 (2%)                                             
      Leukocytosis                                                               2 (4%)                                             
      Necrosis, Coagulative                            5 (10%)      4 (14%)      2 (4%)                                             
      Thrombosis                                                    1 (4%)                                                          
   Mesentery                                          (41)         (19)         (48)                                                
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Pancreas                                           (48)         (20)         (49)                                                
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Acinus, Atrophy                                  1 (2%)       2 (10%)      2 (4%)                                             
      Acinus, Hyperplasia                              2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Ectasia                                                              1 (2%)                                             
   Salivary Glands                                    (49)         (21)         (50)                                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (47)         (50)                                                
      Acanthosis                                                    4 (9%)      20 (40%)                                            
      Acanthosis, Focal                                2 (4%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Hyperkeratosis                                                1 (2%)      23 (46%)                                            
      Hyperkeratosis, Focal                            1 (2%)                                                                       
      Hyperplasia, Focal                               2 (4%)       7 (15%)     11 (22%)                                            
      Inflammation, Chronic Active                                               5 (10%)                                            
   Stomach, Glandular                                 (47)         (20)         (50)                                                
      Cyst                                             1 (2%)                    5 (10%)                                            
      Diverticulum                                     1 (2%)                                                                       
      Dysplasia                                        1 (2%)                                                                       
   Tooth                                              (50)         (20)         (50)                                                
      Dysplasia                                        8 (16%)      1 (5%)       3 (6%)                                             
      Inflammation, Chronic Active                     2 (4%)                    6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (21)         (50)                                                
      Cardiomyopathy, Chronic                          1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Valve, Bacterium                                              1 (5%)                                                          
      Valve, Inflammation, Chronic Active                           1 (5%)                                                          
      Valve, Thrombosis                                             1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (21)         (50)                                                
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Cyst                                                                       2 (4%)                                             
      Degeneration, Fatty                                                        1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Hypertrophy                                                                3 (6%)                                             
   Adrenal Gland, Medulla                             (50)         (21)         (50)                                                
      Hyperplasia                                      5 (10%)      1 (5%)       4 (8%)                                             
   Islets, Pancreatic                                 (48)         (19)         (49)                                                
      Hyperplasia                                                                1 (2%)                                             
   Parathyroid Gland                                  (41)         (19)         (45)                                                
      Cyst                                             3 (7%)                    1 (2%)                                             
   Pituitary Gland                                    (46)         (20)         (41)                                                
      Pars Distalis, Cyst                              2 (4%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (49)         (22)         (50)                                                
      Follicle, Cyst                                   1 (2%)       1 (5%)       2 (4%)                                             
      Follicular Cell, Hyperplasia                     7 (14%)      1 (5%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (45)         (20)         (49)                                                
      Hyperplasia                                                                1 (2%)                                             
   Penis                                              (2)          (4)          (1)                                                 
      Hemorrhage                                                    1 (25%)                                                         
   Preputial Gland                                    (6)          (6)          (3)                                                 
      Inflammation, Chronic Active                                  2 (33%)      1 (33%)                                            
      Duct, Dilatation                                 4 (67%)      2 (33%)      2 (67%)                                            
   Prostate                                           (48)         (21)         (49)                                                
      Inflammation, Chronic Active                                  1 (5%)       3 (6%)                                             
   Seminal Vesicle                                    (43)         (20)         (46)                                                
      Inflammation, Chronic Active                                  1 (5%)       1 (2%)                                             
   Testes                                             (50)         (21)         (50)                                                
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Germinal Epithelium, Degeneration                             1 (5%)                                                          
      Seminiferous Tubule, Atrophy                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (21)         (50)                                                
      Femoral, Hyperplasia                                          5 (24%)      6 (12%)                                            
   Lymph Node                                         (50)         (24)         (49)                                                
      Axillary, Hyperplasia, Plasma Cell                            1 (4%)       1 (2%)                                             
      Inguinal, Hyperplasia, Plasma Cell                            1 (4%)                                                          
      Lumbar, Hyperplasia, Plasma Cell                              1 (4%)                                                          
      Mediastinal, Inflammation, Suppurative                                     1 (2%)                                             
      Mesenteric, Angiectasis                         10 (20%)      6 (25%)     17 (35%)                                            
      Mesenteric, Cyst                                              1 (4%)                                                          
      Mesenteric, Hematopoietic Cell Proliferation    12 (24%)      5 (21%)     17 (35%)                                            
      Mesenteric, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Mesenteric, Thrombosis                                        1 (4%)                                                          
   Lymph Node, Mandibular                             (48)         (20)         (49)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                                                   3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Chronic Active                                  1 (5%)                                                          
      Pigmentation, Hemosiderin                                                  2 (4%)                                             
   Spleen                                             (49)         (26)         (50)                                                
      Hematopoietic Cell Proliferation                23 (47%)     10 (38%)     23 (46%)                                            
   Thymus                                             (27)         (12)         (24)                                                
      Cyst                                             1 (4%)       2 (17%)      1 (4%)                                             
      Necrosis                                                      1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (33)         (49)                                                
      Alopecia                                         1 (2%)                    3 (6%)                                             
      Fibrosis                                         3 (6%)                    2 (4%)                                             
      Hyperkeratosis                                                1 (3%)                                                          
      Inflammation, Chronic Active                     9 (18%)      6 (18%)      8 (16%)                                            
      Metaplasia, Osseous                                           1 (3%)                                                          
      Necrosis, Coagulative                                         1 (3%)                                                          
      Parasite External                                1 (2%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (30)         (50)                                                
      Joint, Femur, Tibia, Metaplasia, Osseous                      1 (3%)                                                          
      Joint, Tarsal, Metaplasia, Osseous              23 (46%)     15 (50%)     22 (44%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (21)         (50)                                                
      Compression                                                   1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (25)         (50)                                                
      Edema, Acute                                     1 (2%)                                                                       
      Hemorrhage, Acute                                1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Leukocytosis                                                  2 (8%)       1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 6 (12%)                                                                      
   Nose                                               (49)         (21)         (50)                                                
      Inflammation, Suppurative                        1 (2%)       1 (5%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)       2 (10%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05038-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            DIMETHOXANE                                        Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 09:04:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 MG/KG      250 MG/      500 MG/                                                
                                                                KG           KG                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                                                              
      Atrophy                                          1 (100%)                                                                     
      Lens, Cataract                                                1 (100%)                                                        
   Harderian Gland                                    (48)         (25)         (48)                                                
      Hyperplasia                                      1 (2%)       1 (4%)                                                          
      Inflammation, Chronic Active                                  1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (23)         (50)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Glomerulosclerosis                               1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)       5 (22%)      1 (2%)                                             
      Infarct                                          1 (2%)       1 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                                  1 (4%)                                                          
      Inflammation, Suppurative                                     1 (4%)       1 (2%)                                             
      Mineralization                                                2 (9%)       3 (6%)                                             
      Necrosis, Coagulative                            1 (2%)                    1 (2%)                                             
      Nephropathy, Chronic                            27 (54%)      4 (17%)     24 (48%)                                            
      Artery, Necrosis, Fibrinoid                                   1 (4%)                                                          
   Ureter                                             (41)         (21)         (43)                                                
      Dilatation                                                    1 (5%)                                                          
   Urethra                                            (23)         (15)         (29)                                                
      Inflammation, Suppurative                                     1 (7%)                                                          
   Urinary Bladder                                    (47)         (21)         (48)                                                
      Dilatation                                                    5 (24%)      1 (2%)                                             
      Inflammation, Chronic Active                                  1 (5%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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