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TR 354 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/05/94   
EXP: 05038                       DIMETHOXANE                   TIME: 09:14:22   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56213    
CONT: N01CP9565302                                             CAS: 828-00-2    
PATHOLOGIST: J. TOFT                         S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


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TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/05/94  
EXP: 05038                       DIMETHOXANE                   TIME: 09:14:22  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56213   
CONT: N01CP9565302                                             CAS: 828-00-2   
PATHOLOGIST: J. TOFT                         S. EUSTIS                         

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      109   509   519   530   542   549   549   600   616   664                 |
 |      665   666   684   689   720   724   729                                   |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 250 MG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 58     UNCENSORED DEATHS 21     CENSORED DEATHS 10   TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      30    102   225   283   446   448   478   509   537   549                 |
 |      551   555   605   611   613   662   667   675   682   688                 |
 |      689                                                                       |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 MG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 10   TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      186   302   423   469   493   549   550   551   576   623                 |
 |      628   646   668   668   668   669   688   695   697   704                 |
 |      715                                                                       |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0  98.3  98.3  98.3  98.3  98.3  90.3  84.3  78.3  66.2      |
 |           |                                                                    |
 |           |                                                                    |
 |250 MG/ KG |    98.3  96.6  94.8  93.1  93.1  87.5  83.3  74.7  68.3  57.6      |
 |           |                                                                    |
 |           |                                                                    |
 |500 MG/ KG |   100.0 100.0  98.3  96.7  95.0  93.0  91.0  82.9  76.8  58.6      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 MG/KG          250 MG/ KG       500 MG/ KG    |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.2%            57.6%            58.6%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.479          P=0.303          P=0.509       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       592.0            505.0            579.4         |
 |NATURAL DEATHS (C)      |       (35.5)           (42.0)           (30.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       646.1            602.1            632.5         |
 |(STANDARD ERROR)        |       (16.7)           (22.0)           (17.1)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 10   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      409   462   539   574   584   596   596   603   628   629                 |
 |      633   697   722   724                                                     |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 250 MG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 11   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      336   454   601   602   614   617   623   635   639   659                 |
 |      680   689   710   711                                                     |
 |  CENSORED DEATHS                                                               |
 |      19    458   458   458   458   458   458   458   458   458                 |
 |      458                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 500 MG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 10   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      196   282   474   493   509   584   634   646   653   654                 |
 |      655   673   680   688   688   709                                         |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 ==================================================================================

                                    DIMETHOXANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0 100.0  98.3  96.3  94.3  84.3  78.3  72.2      |
 |           |                                                                    |
 |           |                                                                    |
 |250 MG/ KG |   100.0 100.0 100.0  98.3  98.3  96.6  96.6  92.5  80.2  71.9      |
 |           |                                                                    |
 |           |                                                                    |
 |500 MG/ KG |   100.0 100.0  98.3  96.7  96.7  94.7  90.6  88.6  78.5  68.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 MG/KG          250 MG/ KG       500 MG/ KG    |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       72.2%            71.9%            68.5%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.768          P=1.000N         P=0.837       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       599.7            612.1            576.1         |
 |NATURAL DEATHS (C)      |       (23.7)           (27.2)           (37.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       654.9            645.9            644.2         |
 |(STANDARD ERROR)        |       (14.5)           (18.0)           (17.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            DIMETHOXANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        250 MG/ KG       = 2
                                                        500 MG/ KG       = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1     2           1           3
      |       2          21           3                 3                               1
      |
      |                  2                  2           3                  3            1  1
   95 +                                     2        2                     3      3
      |                                                                                    11
      |                                              2                        2   3   3     1 1
      |                                                                               3        3
   90 +                                                                       2     2         11
      |
P     |                                                                             2   2
E     |                                                                                        1       1
R  85 +                                                                                 2    2 3   3
C     |                                                                                      2 2       1 1
E     |                                                                                            3     13      1
N     |                                                                                                   33
T  80 +
      |                                                                                        22          3  3  11
S     |
U     |                                                                                         2       2     3   1 1
R  75 +                                                                                                 22
V     |                                                                                                             11
I     |                                                                                                              1   1
V     |
A  70 +                                                                                                  2       2       11
L     |                                                                                                          22  3    1 1
      |
      |                                                                                                           22 33     1
   65 +
      |                                                                                                            22
      |                                                                                                             2233
      |                                                                                                                3 3
   60 +
      |                                                                                                                  3  3
      |                                                                                                              2      2
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.

                                                            DIMETHOXANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        250 MG/ KG       = 2
                                                        500 MG/ KG       = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                              3                     2           1
      |                                3             3       2           1      21
      |
      |                                              3                          21 3         1         2
   95 +                                                                            3  3
      |                                                                                      1    1
P     |                                                                               3 3         1 1  2 2
E     |                                                                                 3           3
R  90 +                                                                                             1  1 22
C     |                                                                                             3       3
E     |
N     |                                                                                                11 2 2 3
T  85 +                                                                                                       33
      |                                                                                                 1  122
S     |                                                                                                      2   2
U     |
R  80 +                                                                                                    11    2  2
V     |                                                                                                     1  3   3  1
I     |                                                                                                             22
V     |                                                                                                            3321 2 1
A  75 +                                                                                                             33
L     |
      |                                                                                                                 2 1 1
      |
   70 +                                                                                                              3  3
      |                                                                                                                 3   3
      |
      |
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.

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