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TR 358 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            OCHRATOXIN A


NTP Experiment-Test: 05036-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 02:27:31




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  303-47-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           80           80           80                                     
  Scheduled Sacrifice                                 30           29           30           30                                     
  Early Deaths                                                                                                                      
    Moribund                                          10           22           11           11                                     
    Dead                                               7            3            4            4                                     
    Gavage Death                                       1            3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           23           35           34                                     
    Dead                                                                                      1                                     
  Animals Examined Microscopically                    50           51           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (28)         (15)         (48)                                   
      Parasite Metazoan                                1 (2%)                                 1 (2%)                                
   Intestine Large, Rectum                            (48)         (28)         (14)         (47)                                   
      Parasite Metazoan                                1 (2%)                                 2 (4%)                                
   Liver                                              (50)         (29)         (19)         (50)                                   
      Basophilic Focus, Multiple                      41 (82%)     15 (52%)     11 (58%)     45 (90%)                               
      Clear Cell Focus                                 4 (8%)                                                                       
      Cytoplasmic Alteration, Focal                                 2 (7%)       2 (11%)      4 (8%)                                
      Cytoplasmic Alteration, Multifocal                                                      1 (2%)                                
      Eosinophilic Focus                               1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active, Multifocal        15 (30%)      3 (10%)      2 (11%)      8 (16%)                               
      Necrosis, Acute                                                                         1 (2%)                                
      Regeneration, Focal                                                                     1 (2%)                                
      Bile Duct, Hyperplasia, Multifocal              13 (26%)      3 (10%)      2 (11%)     18 (36%)                               
      Centrilobular, Degeneration                      2 (4%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic,                                                                                     
           Diffuse                                     1 (2%)       3 (10%)      1 (5%)                                             
      Periportal, Fibrosis, Chronic, Multifocal                                               1 (2%)                                
      Periportal, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                      3 (6%)       2 (7%)                    1 (2%)                                
   Mesentery                                          (1)          (1)          (1)          (1)                                    
      Inflammation, Chronic Active                     1 (100%)                               1 (100%)                              
      Perivascular, Inflammation, Chronic Active                    1 (100%)                                                        
   Pancreas                                           (50)         (29)         (14)         (50)                                   
      Acinus, Atrophy                                 12 (24%)      2 (7%)       2 (14%)     14 (28%)                               
      Acinus, Degeneration, Multifocal                 1 (2%)                                                                       
      Acinus, Focal Cellular Change                                                           1 (2%)                                
      Duct, Ectasia                                                                           3 (6%)                                
      Perivascular, Inflammation, Chronic Active,                                                                                   
           Multifocal                                               1 (3%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (50)         (28)         (15)         (50)                                   
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Acinus, Atrophy, Focal                                                                  1 (2%)                                
   Stomach, Forestomach                               (50)         (28)         (15)         (49)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (4%)                    1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Stomach, Glandular                                 (50)         (28)         (15)         (49)                                   
      Ulcer                                            1 (2%)                                                                       
   Tongue                                             (1)                       (1)                                                 
      Epithelium, Hyperkeratosis, Focal                                          1 (100%)                                           
      Epithelium, Hyperplasia                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (28)         (15)         (50)                                   
      Degeneration, Chronic, Multifocal               34 (68%)     10 (36%)      9 (60%)     41 (82%)                               
      Epicardium, Inflammation, Chronic, Multifocal                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (29)         (15)         (50)                                   
      Accessory Adrenal Cortical Nodule                                          1 (7%)                                             
      Atrophy, Diffuse                                                                        1 (2%)                                
      Degeneration                                     2 (4%)                                                                       
      Degeneration, Fatty                             13 (26%)      3 (10%)      5 (33%)     13 (26%)                               
      Degeneration, Fatty, Focal                                                 1 (7%)                                             
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Hyperplasia                                     14 (28%)      6 (21%)                  13 (26%)                               
      Hypertrophy                                      2 (4%)       2 (7%)                    3 (6%)                                
      Necrosis, Acute                                               1 (3%)       2 (13%)      3 (6%)                                
   Adrenal Gland, Medulla                             (50)         (27)         (15)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (4%)       1 (7%)       7 (14%)                               
   Pituitary Gland                                    (49)         (41)         (35)         (49)                                   
      Pars Distalis, Cyst                             21 (43%)      9 (22%)      9 (26%)     17 (35%)                               
      Pars Distalis, Hyperplasia                      15 (31%)      9 (22%)      8 (23%)     16 (33%)                               
      Pars Nervosa, Hyperplasia, Glandular                          1 (2%)                                                          
      Rathke's Cleft, Cyst                                          3 (7%)                                                          
   Thyroid Gland                                      (50)         (32)         (18)         (50)                                   
      C-Cell, Hyperplasia                             24 (48%)     14 (44%)      9 (50%)     27 (54%)                               
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (29)         (17)         (47)                                   
      Hyperplasia                                      3 (6%)                                 8 (17%)                               
      Infiltration Cellular, Focal, Lipocyte           1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (3%)       2 (12%)      6 (13%)                               
      Duct, Cyst                                       1 (2%)       1 (3%)                    1 (2%)                                
      Duct, Hyperplasia, Multifocal, Squamous                                    1 (6%)       1 (2%)                                
   Ovary                                              (49)         (29)         (19)         (50)                                   
      Edema, Diffuse                                                                          1 (2%)                                
      Follicle, Cyst                                                2 (7%)                    2 (4%)                                
      Periovarian Tissue, Cyst                         1 (2%)       3 (10%)      4 (21%)      1 (2%)                                
   Uterus                                             (49)         (32)         (19)         (50)                                   
      Dilatation                                       1 (2%)       1 (3%)                                                          
      Inflammation, Chronic Active                                  1 (3%)                                                          
      Endometrium, Hyperplasia, Cystic, Glandular,                                                                                  
           Multifocal                                  3 (6%)       4 (13%)      2 (11%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (28)         (15)         (50)                                   
      Femoral, Hyperplasia, Reticulum Cell                                                    2 (4%)                                
   Lymph Node                                         (50)         (27)         (16)         (50)                                   
      Lumbar, Cyst                                                               1 (6%)                                             
      Lumbar, Inflammation, Chronic Active,                                                                                         
          Multifocal                                                             1 (6%)                                             
      Mesenteric, Hyperplasia, Lymphoid, Multifocal                                           1 (2%)                                
      Mesenteric, Sinus, Ectasia                                    1 (4%)                                                          
      Pancreatic, Inflammation, Chronic Active,                                                                                     
           Multifocal                                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (26)         (15)         (50)                                   
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Hyperplasia, Lymphoid, Multifocal                                          1 (7%)                                             
      Hyperplasia, Multifocal, Reticulum Cell          1 (2%)                                                                       
   Spleen                                             (50)         (29)         (16)         (50)                                   
      Degeneration, Fatty, Focal                                                 1 (6%)                                             
      Depletion Lymphoid                                            1 (3%)                                                          
      Edema, Diffuse                                                                          1 (2%)                                
      Red Pulp, Fibrosis                                            1 (3%)                                                          
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     2 (4%)       3 (10%)      2 (13%)      5 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (43)         (27)         (11)         (44)                                   
      Depletion Lymphoid, Multifocal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (40)         (34)         (49)                                   
      Hyperplasia, Cystic, Multifocal                 46 (98%)     22 (55%)     17 (50%)     48 (98%)                               
   Skin                                               (49)         (31)         (16)         (50)                                   
      Acanthosis, Multifocal                                                     1 (6%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Diffuse                                                        1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (28)         (15)         (50)                                   
      Femur, Hyperostosis                              1 (2%)                                                                       
      Femur, Osteopetrosis                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (28)         (15)         (50)                                   
      Compression                                      5 (10%)      7 (25%)      2 (13%)      3 (6%)                                
      Cyst                                             1 (2%)                                                                       
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
      Ventricle, Hydrocephalus                         5 (10%)      7 (25%)      2 (13%)      2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (18)         (50)                                   
      Foreign Body, Multifocal                         4 (8%)       5 (16%)      1 (6%)       2 (4%)                                
      Alveolar Epithelium, Hyperplasia                              3 (9%)       1 (6%)       4 (8%)                                
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                 30 (60%)     12 (38%)      8 (44%)     24 (48%)                               
      Perivascular, Edema, Acute                                    4 (13%)                   1 (2%)                                
   Nose                                               (50)         (28)         (15)         (50)                                   
      Lumen, Foreign Body                              7 (14%)                                6 (12%)                               
      Mucosa, Inflammation, Acute, Multifocal          5 (10%)                                5 (10%)                               
      Mucosa, Inflammation, Chronic Active,                                                                                         
          Multifocal                                                                          2 (4%)                                
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Multifocal                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (2)          (5)          (4)                                    
      Cornea, Hyperplasia                                           1 (50%)                                                         
      Lens, Cataract                                   2 (50%)      1 (50%)      5 (100%)     4 (100%)                              
      Retina, Atrophy, Diffuse                         2 (50%)      1 (50%)      5 (100%)     4 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (51)         (50)         (50)                                   
      Cyst                                                                       1 (2%)      25 (50%)                               
      Cyst, Multiple                                                                          6 (12%)                               
      Hydronephrosis                                                             1 (2%)                                             
      Mineralization, Multifocal                                                 1 (2%)                                             
      Nephropathy, Chronic, Diffuse                   35 (70%)     40 (78%)     44 (88%)     46 (92%)                               
      Cortex, Hemorrhage, Focal                                                  1 (2%)                                             
      Pelvis, Epithelium, Hyperplasia, Multifocal                                             2 (4%)                                
      Renal Tubule, Epithelium, Cytoplasmic                                                                                         
          Alteration, Focal                                                      1 (2%)       2 (4%)                                
      Renal Tubule, Epithelium, Degeneration,                                                                                       
          Multifocal                                                            49 (98%)     49 (98%)                               
      Renal Tubule, Epithelium, Hyperplasia, Focal                               6 (12%)     12 (24%)                               
      Renal Tubule, Epithelium, Hyperplasia,                                                                                        
          Multifocal                                                             6 (12%)      1 (2%)                                
      Renal Tubule, Epithelium, Karyomegaly,                                                                                        
          Multifocal                                                8 (16%)     50 (100%)    50 (100%)                              
      Renal Tubule, Epithelium, Pigmentation,                                                                                       
          Diffuse                                      1 (2%)                                                                       
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Focal                                                                 1 (2%)       7 (14%)                               
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Multifocal                                                            2 (4%)       9 (18%)                               
   Urinary Bladder                                    (50)         (27)         (15)         (50)                                   
      Calculus Gross Observation                                                 1 (7%)                                             
      Ectasia                                                                    2 (13%)                                            
      Hemorrhage                                                    1 (4%)                                                          
      Inflammation, Acute                                           1 (4%)                                                          
      Mucosa, Hyperplasia, Diffuse                                               1 (7%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           80           80           80                                     
  Scheduled Sacrifice                                 30           29           29           30                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       4            6            2            1                                     
    Moribund                                           7           13           14           23                                     
    Dead                                                            6            9            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           26           26           23                                     
  Animals Examined Microscopically                    50           51           51           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (23)         (20)         (50)                                   
      Inflammation, Chronic Active, Diffuse                                      1 (5%)                                             
   Intestine Large, Colon                             (50)         (25)         (24)         (50)                                   
      Parasite Metazoan                                1 (2%)                                 2 (4%)                                
   Intestine Large, Rectum                            (48)         (23)         (24)         (47)                                   
      Parasite Metazoan                                6 (13%)      2 (9%)                    3 (6%)                                
   Intestine Small, Duodenum                          (50)         (25)         (23)         (50)                                   
      Necrosis, Acute, Focal                                                                  1 (2%)                                
   Liver                                              (50)         (26)         (26)         (50)                                   
      Angiectasis, Multifocal                                                                 1 (2%)                                
      Basophilic Focus, Multiple                      40 (80%)     13 (50%)      8 (31%)     33 (66%)                               
      Clear Cell Focus                                 9 (18%)                                6 (12%)                               
      Clear Cell Focus, Multiple                                                              1 (2%)                                
      Congestion                                       1 (2%)       1 (4%)                                                          
      Cytoplasmic Alteration, Focal                                              1 (4%)       2 (4%)                                
      Degeneration, Cystic, Focal                      2 (4%)       1 (4%)       1 (4%)       1 (2%)                                
      Eosinophilic Focus                                                                      2 (4%)                                
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)                                 1 (2%)                                
      Inflammation, Chronic Active, Multifocal         8 (16%)      1 (4%)                    3 (6%)                                
      Mixed Cell Focus                                              1 (4%)                                                          
      Necrosis, Acute                                  1 (2%)       5 (19%)      1 (4%)       1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Bile Duct, Hyperplasia, Multifocal              38 (76%)     16 (62%)     14 (54%)     30 (60%)                               
      Centrilobular, Vacuolization Cytoplasmic,                                                                                     
           Diffuse                                    23 (46%)      5 (19%)      2 (8%)      13 (26%)                               
      Periportal, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                                   1 (4%)       1 (4%)       1 (2%)                                
   Mesentery                                          (1)          (7)          (5)          (11)                                   
      Inflammation, Chronic Active                                  3 (43%)      4 (80%)      3 (27%)                               
   Pancreas                                           (50)         (26)         (24)         (50)                                   
      Inflammation, Acute, Multifocal                                                         1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic, Diffuse                   1 (2%)                                 1 (2%)                                
      Acinus, Atrophy                                 17 (34%)      8 (31%)      1 (4%)      14 (28%)                               
      Acinus, Focal Cellular Change                    6 (12%)                                5 (10%)                               
      Acinus, Hyperplasia, Focal                       6 (12%)                   2 (8%)       8 (16%)                               
      Duct, Ectasia, Multifocal                        1 (2%)                                                                       
      Perivascular, Inflammation, Chronic Active,                                                                                   
           Multifocal                                               1 (4%)                    3 (6%)                                
   Salivary Glands                                    (50)         (26)         (25)         (49)                                   
      Acinus, Atrophy, Multifocal                                                             2 (4%)                                
   Stomach, Forestomach                               (50)         (25)         (25)         (50)                                   
      Acanthosis                                                    1 (4%)                    8 (16%)                               
      Acanthosis, Focal                                1 (2%)                                 1 (2%)                                
      Acanthosis, Multifocal                                                                  1 (2%)                                
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Erosion                                                                                 1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       2 (8%)       2 (8%)       6 (12%)                               
      Ulcer                                            1 (2%)       2 (8%)       2 (8%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (25)         (25)         (49)                                   
      Hyperplasia, Multifocal                                                                 1 (2%)                                
      Inflammation, Acute                                           1 (4%)                                                          
      Ulcer                                                                                   4 (8%)                                
   Tongue                                                          (3)          (2)          (2)                                    
      Epithelium, Hyperkeratosis, Focal                                                       1 (50%)                               
      Epithelium, Hyperplasia                                       1 (33%)                   2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (26)         (25)         (50)                                   
      Degeneration, Chronic, Multifocal               47 (94%)     26 (100%)    22 (88%)     47 (94%)                               
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Epicardium, Fibrosis, Multifocal                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (25)         (25)         (50)                                   
      Cytoplasmic Alteration                                                     1 (4%)       1 (2%)                                
      Degeneration                                                                            2 (4%)                                
      Degeneration, Fatty                              6 (12%)      2 (8%)       3 (12%)     12 (24%)                               
      Hyperplasia                                     18 (36%)      3 (12%)      2 (8%)      13 (26%)                               
      Hyperplasia, Multifocal                                                                 1 (2%)                                
      Hypertrophy                                      5 (10%)                   1 (4%)       2 (4%)                                
      Bilateral, Atrophy, Diffuse                                                1 (4%)                                             
   Adrenal Gland, Medulla                             (50)         (25)         (26)         (49)                                   
      Hyperplasia                                      7 (14%)      2 (8%)       4 (15%)     10 (20%)                               
      Hyperplasia, Focal                                                                      1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (50)         (26)         (26)         (50)                                   
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (50)         (33)         (27)         (49)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (3%)       2 (7%)       3 (6%)                                
      Pars Distalis, Hyperplasia                       6 (12%)      4 (12%)      3 (11%)     14 (29%)                               
      Pars Intermedia, Cyst                            1 (2%)                                 1 (2%)                                
      Pars Nervosa, Hyperplasia                                                               1 (2%)                                
      Rathke's Cleft, Cyst, Multiple                                                          1 (2%)                                
   Thyroid Gland                                      (50)         (29)         (26)         (50)                                   
      C-Cell, Hyperplasia                             24 (48%)      6 (21%)     10 (38%)     16 (32%)                               
      Follicle, Cyst                                   1 (2%)                                 2 (4%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)          (2)                                    
      Inflammation, Chronic Active, Diffuse                                                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (26)         (25)         (50)                                   
      Atrophy, Diffuse                                                           1 (4%)                                             
   Preputial Gland                                    (50)         (28)         (25)         (48)                                   
      Hyperplasia                                                   1 (4%)       1 (4%)                                             
      Inflammation, Chronic Active, Multifocal        44 (88%)     11 (39%)     11 (44%)     38 (79%)                               
      Duct, Ectasia                                    8 (16%)      1 (4%)                    3 (6%)                                
   Prostate                                           (50)         (26)         (25)         (50)                                   
      Atrophy, Diffuse                                                           1 (4%)                                             
      Cyst                                                                                    1 (2%)                                
      Dilatation, Diffuse                                                                     1 (2%)                                
      Inflammation, Acute                                           1 (4%)                                                          
      Inflammation, Chronic Active, Multifocal        15 (30%)      2 (8%)                   12 (24%)                               
      Epithelium, Hyperplasia, Multifocal                                        1 (4%)                                             
   Seminal Vesicle                                                 (1)                       (1)                                    
      Dilatation                                                    1 (100%)                                                        
      Inflammation, Acute                                           1 (100%)                                                        
   Testes                                             (50)         (50)         (48)         (50)                                   
      Inflammation, Chronic Active, Diffuse,                                                                                        
          Necrotizing                                                                         1 (2%)                                
      Germinal Epithelium, Atrophy                    43 (86%)      1 (2%)      40 (83%)     33 (66%)                               
      Interstitial Cell, Hyperplasia                  22 (44%)     13 (26%)     14 (29%)     24 (48%)                               
      Perivascular, Inflammation, Chronic,                                                                                          
          Multifocal                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                    (9)                                    
      Neutrophilia                                                                            5 (56%)                               
   Bone Marrow                                        (50)         (25)         (25)         (50)                                   
      Femoral, Hyperplasia, Diffuse, Neutrophil                     1 (4%)                    1 (2%)                                
   Lymph Node                                         (50)         (28)         (25)         (50)                                   
      Inguinal, Sinus, Ectasia                                      1 (4%)                                                          
      Lumbar, Sinus, Ectasia                                        1 (4%)                                                          
      Mediastinal, Congestion                                       1 (4%)                                                          
      Mediastinal, Hemorrhage, Multifocal                                                     1 (2%)                                
      Mesenteric, Cyst                                                                        1 (2%)                                
      Mesenteric, Inflammation, Chronic Active,                                                                                     
           Multifocal                                                                         1 (2%)                                
      Mesenteric, Sinus, Ectasia                                    1 (4%)                                                          
   Lymph Node, Mandibular                             (49)         (28)         (23)         (50)                                   
      Hemorrhage, Multifocal                                                                  2 (4%)                                
      Infiltration Cellular, Plasma Cell                            3 (11%)                   1 (2%)                                
      Necrosis, Acute, Multifocal                      1 (2%)                                                                       
   Spleen                                             (50)         (29)         (27)         (50)                                   
      Angiectasis                                                   1 (3%)                                                          
      Depletion Lymphoid                               3 (6%)       5 (17%)                                                         
      Infiltration Cellular, Multifocal, Lipocyte      1 (2%)                                                                       
      Red Pulp, Fibrosis                               2 (4%)       2 (7%)       1 (4%)       2 (4%)                                
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     3 (6%)       1 (3%)       1 (4%)       8 (16%)                               
      Red Pulp, Infiltration Cellular, Multifocal,                                                                                  
           Lipocyte                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (22)         (23)         (40)                                   
      Hyperplasia, Cystic, Multifocal                 37 (95%)     18 (82%)     18 (78%)     38 (95%)                               
   Skin                                               (49)         (32)         (30)         (49)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                1 (3%)       1 (3%)                                             
      Subcutaneous Tissue, Fibrosis                                 1 (3%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Diffuse                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (25)         (25)         (50)                                   
      Compression                                      1 (2%)       1 (4%)       1 (4%)       1 (2%)                                
      Ventricle, Hydrocephalus                         1 (2%)       2 (8%)       1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (30)         (27)         (50)                                   
      Congestion                                       2 (4%)                    2 (7%)                                             
      Edema, Acute, Diffuse                            3 (6%)                                                                       
      Foreign Body, Multifocal                        11 (22%)      9 (30%)      5 (19%)      6 (12%)                               
      Mineralization, Focal                            1 (2%)                                                                       
      Pigmentation                                                  2 (7%)                                                          
      Alveolar Epithelium, Hyperplasia                 3 (6%)       1 (3%)       2 (7%)       1 (2%)                                
      Interstitium, Inflammation, Acute, Multifocal                 2 (7%)       1 (4%)                                             
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                 21 (42%)      5 (17%)      2 (7%)      14 (28%)                               
      Perivascular, Edema, Acute                                    4 (13%)                                                         
   Nose                                               (50)         (25)         (24)         (50)                                   
      Lumen, Foreign Body                                                                     2 (4%)                                
      Nasolacrimal Duct, Hyperplasia                                             1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (1)          (4)          (2)                                    
      Lens, Cataract                                   3 (100%)     1 (100%)     2 (50%)      2 (100%)                              
      Retina, Atrophy, Diffuse                         3 (100%)     1 (100%)     2 (50%)      2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (51)         (51)         (50)                                   
      Cyst                                                                                    6 (12%)                               
      Cyst, Multiple                                                1 (2%)                    4 (8%)                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Hydronephrosis                                                1 (2%)                    1 (2%)                                
      Nephropathy, Chronic, Diffuse                   48 (96%)     51 (100%)    51 (100%)    48 (96%)                               
      Pelvis, Epithelium, Hyperplasia, Multifocal                                             1 (2%)                                
      Pelvis, Epithelium, Hyperplasia, Multifocal,                                                                                  
           Papillary                                                                          1 (2%)                                
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Epithelium, Cytoplasmic                                                                                         
          Alteration, Focal                            1 (2%)                    2 (4%)       7 (14%)                               
      Renal Tubule, Epithelium, Cytoplasmic                                                                                         
          Alteration, Multifocal                                                 1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Epithelium, Degeneration,                                                                                       
          Multifocal                                                            50 (98%)     49 (98%)                               
      Renal Tubule, Epithelium, Hyperplasia, Focal     1 (2%)                   11 (22%)     15 (30%)                               
      Renal Tubule, Epithelium, Hyperplasia,                                                                                        
          Multifocal                                                1 (2%)       5 (10%)      9 (18%)                               
      Renal Tubule, Epithelium, Karyomegaly,                                                                                        
          Multifocal                                                1 (2%)      51 (100%)    50 (100%)                              
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Focal                                                                 4 (8%)      13 (26%)                               
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Multifocal                                                            6 (12%)     13 (26%)                               
      Vein, Dilatation, Focal                          1 (2%)                                                                       
   Urethra                                                         (1)                                                              
      Calculus Micro Observation Only                               1 (100%)                                                        
   Urinary Bladder                                    (50)         (23)         (24)         (50)                                   
      Calculus Micro Observation Only                  2 (4%)                                 1 (2%)                                
      Ectasia                                                       1 (4%)                                                          
      Inflammation, Acute                                           1 (4%)                                                          
      Mucosa, Hyperplasia, Diffuse                                                            1 (2%)                                
      Serosa, Necrosis, Chronic Active, Multifocal                                            1 (2%)                                
      Submucosa, Inflammation, Chronic Active,                                                                                      
           Multifocal                                                                         1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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