Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3072

TR 358 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            OCHRATOXIN A


NTP Experiment-Test: 05036-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 02:27:31




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  303-47-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           80           80           80                                     
  Scheduled Sacrifice                                 30           29           30           30                                     
  Early Deaths                                                                                                                      
    Moribund                                          10           22           11           11                                     
    Dead                                               7            3            4            4                                     
    Gavage Death                                       1            3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           23           35           34                                     
    Dead                                                                                      1                                     
  Animals Examined Microscopically                    50           51           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (28)         (15)         (48)                                   
      Parasite Metazoan                                1 (2%)                                 1 (2%)                                
   Intestine Large, Rectum                            (48)         (28)         (14)         (47)                                   
      Parasite Metazoan                                1 (2%)                                 2 (4%)                                
   Liver                                              (50)         (29)         (19)         (50)                                   
      Basophilic Focus, Multiple                      41 (82%)     15 (52%)     11 (58%)     45 (90%)                               
      Clear Cell Focus                                 4 (8%)                                                                       
      Cytoplasmic Alteration, Focal                                 2 (7%)       2 (11%)      4 (8%)                                
      Cytoplasmic Alteration, Multifocal                                                      1 (2%)                                
      Eosinophilic Focus                               1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active, Multifocal        15 (30%)      3 (10%)      2 (11%)      8 (16%)                               
      Necrosis, Acute                                                                         1 (2%)                                
      Regeneration, Focal                                                                     1 (2%)                                
      Bile Duct, Hyperplasia, Multifocal              13 (26%)      3 (10%)      2 (11%)     18 (36%)                               
      Centrilobular, Degeneration                      2 (4%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic,                                                                                     
           Diffuse                                     1 (2%)       3 (10%)      1 (5%)                                             
      Periportal, Fibrosis, Chronic, Multifocal                                               1 (2%)                                
      Periportal, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                      3 (6%)       2 (7%)                    1 (2%)                                
   Mesentery                                          (1)          (1)          (1)          (1)                                    
      Inflammation, Chronic Active                     1 (100%)                               1 (100%)                              
      Perivascular, Inflammation, Chronic Active                    1 (100%)                                                        
   Pancreas                                           (50)         (29)         (14)         (50)                                   
      Acinus, Atrophy                                 12 (24%)      2 (7%)       2 (14%)     14 (28%)                               
      Acinus, Degeneration, Multifocal                 1 (2%)                                                                       
      Acinus, Focal Cellular Change                                                           1 (2%)                                
      Duct, Ectasia                                                                           3 (6%)                                
      Perivascular, Inflammation, Chronic Active,                                                                                   
           Multifocal                                               1 (3%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (50)         (28)         (15)         (50)                                   
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Acinus, Atrophy, Focal                                                                  1 (2%)                                
   Stomach, Forestomach                               (50)         (28)         (15)         (49)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (4%)                    1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
   Stomach, Glandular                                 (50)         (28)         (15)         (49)                                   
      Ulcer                                            1 (2%)                                                                       
   Tongue                                             (1)                       (1)                                                 
      Epithelium, Hyperkeratosis, Focal                                          1 (100%)                                           
      Epithelium, Hyperplasia                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (28)         (15)         (50)                                   
      Degeneration, Chronic, Multifocal               34 (68%)     10 (36%)      9 (60%)     41 (82%)                               
      Epicardium, Inflammation, Chronic, Multifocal                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (29)         (15)         (50)                                   
      Accessory Adrenal Cortical Nodule                                          1 (7%)                                             
      Atrophy, Diffuse                                                                        1 (2%)                                
      Degeneration                                     2 (4%)                                                                       
      Degeneration, Fatty                             13 (26%)      3 (10%)      5 (33%)     13 (26%)                               
      Degeneration, Fatty, Focal                                                 1 (7%)                                             
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Hyperplasia                                     14 (28%)      6 (21%)                  13 (26%)                               
      Hypertrophy                                      2 (4%)       2 (7%)                    3 (6%)                                
      Necrosis, Acute                                               1 (3%)       2 (13%)      3 (6%)                                
   Adrenal Gland, Medulla                             (50)         (27)         (15)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (4%)       1 (7%)       7 (14%)                               
   Pituitary Gland                                    (49)         (41)         (35)         (49)                                   
      Pars Distalis, Cyst                             21 (43%)      9 (22%)      9 (26%)     17 (35%)                               
      Pars Distalis, Hyperplasia                      15 (31%)      9 (22%)      8 (23%)     16 (33%)                               
      Pars Nervosa, Hyperplasia, Glandular                          1 (2%)                                                          
      Rathke's Cleft, Cyst                                          3 (7%)                                                          
   Thyroid Gland                                      (50)         (32)         (18)         (50)                                   
      C-Cell, Hyperplasia                             24 (48%)     14 (44%)      9 (50%)     27 (54%)                               
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (29)         (17)         (47)                                   
      Hyperplasia                                      3 (6%)                                 8 (17%)                               
      Infiltration Cellular, Focal, Lipocyte           1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (3%)       2 (12%)      6 (13%)                               
      Duct, Cyst                                       1 (2%)       1 (3%)                    1 (2%)                                
      Duct, Hyperplasia, Multifocal, Squamous                                    1 (6%)       1 (2%)                                
   Ovary                                              (49)         (29)         (19)         (50)                                   
      Edema, Diffuse                                                                          1 (2%)                                
      Follicle, Cyst                                                2 (7%)                    2 (4%)                                
      Periovarian Tissue, Cyst                         1 (2%)       3 (10%)      4 (21%)      1 (2%)                                
   Uterus                                             (49)         (32)         (19)         (50)                                   
      Dilatation                                       1 (2%)       1 (3%)                                                          
      Inflammation, Chronic Active                                  1 (3%)                                                          
      Endometrium, Hyperplasia, Cystic, Glandular,                                                                                  
           Multifocal                                  3 (6%)       4 (13%)      2 (11%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (28)         (15)         (50)                                   
      Femoral, Hyperplasia, Reticulum Cell                                                    2 (4%)                                
   Lymph Node                                         (50)         (27)         (16)         (50)                                   
      Lumbar, Cyst                                                               1 (6%)                                             
      Lumbar, Inflammation, Chronic Active,                                                                                         
          Multifocal                                                             1 (6%)                                             
      Mesenteric, Hyperplasia, Lymphoid, Multifocal                                           1 (2%)                                
      Mesenteric, Sinus, Ectasia                                    1 (4%)                                                          
      Pancreatic, Inflammation, Chronic Active,                                                                                     
           Multifocal                                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (50)         (26)         (15)         (50)                                   
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Hyperplasia, Lymphoid, Multifocal                                          1 (7%)                                             
      Hyperplasia, Multifocal, Reticulum Cell          1 (2%)                                                                       
   Spleen                                             (50)         (29)         (16)         (50)                                   
      Degeneration, Fatty, Focal                                                 1 (6%)                                             
      Depletion Lymphoid                                            1 (3%)                                                          
      Edema, Diffuse                                                                          1 (2%)                                
      Red Pulp, Fibrosis                                            1 (3%)                                                          
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     2 (4%)       3 (10%)      2 (13%)      5 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (43)         (27)         (11)         (44)                                   
      Depletion Lymphoid, Multifocal                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (40)         (34)         (49)                                   
      Hyperplasia, Cystic, Multifocal                 46 (98%)     22 (55%)     17 (50%)     48 (98%)                               
   Skin                                               (49)         (31)         (16)         (50)                                   
      Acanthosis, Multifocal                                                     1 (6%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Diffuse                                                        1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (28)         (15)         (50)                                   
      Femur, Hyperostosis                              1 (2%)                                                                       
      Femur, Osteopetrosis                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (28)         (15)         (50)                                   
      Compression                                      5 (10%)      7 (25%)      2 (13%)      3 (6%)                                
      Cyst                                             1 (2%)                                                                       
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
      Ventricle, Hydrocephalus                         5 (10%)      7 (25%)      2 (13%)      2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (18)         (50)                                   
      Foreign Body, Multifocal                         4 (8%)       5 (16%)      1 (6%)       2 (4%)                                
      Alveolar Epithelium, Hyperplasia                              3 (9%)       1 (6%)       4 (8%)                                
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                 30 (60%)     12 (38%)      8 (44%)     24 (48%)                               
      Perivascular, Edema, Acute                                    4 (13%)                   1 (2%)                                
   Nose                                               (50)         (28)         (15)         (50)                                   
      Lumen, Foreign Body                              7 (14%)                                6 (12%)                               
      Mucosa, Inflammation, Acute, Multifocal          5 (10%)                                5 (10%)                               
      Mucosa, Inflammation, Chronic Active,                                                                                         
          Multifocal                                                                          2 (4%)                                
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Multifocal                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (2)          (5)          (4)                                    
      Cornea, Hyperplasia                                           1 (50%)                                                         
      Lens, Cataract                                   2 (50%)      1 (50%)      5 (100%)     4 (100%)                              
      Retina, Atrophy, Diffuse                         2 (50%)      1 (50%)      5 (100%)     4 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (51)         (50)         (50)                                   
      Cyst                                                                       1 (2%)      25 (50%)                               
      Cyst, Multiple                                                                          6 (12%)                               
      Hydronephrosis                                                             1 (2%)                                             
      Mineralization, Multifocal                                                 1 (2%)                                             
      Nephropathy, Chronic, Diffuse                   35 (70%)     40 (78%)     44 (88%)     46 (92%)                               
      Cortex, Hemorrhage, Focal                                                  1 (2%)                                             
      Pelvis, Epithelium, Hyperplasia, Multifocal                                             2 (4%)                                
      Renal Tubule, Epithelium, Cytoplasmic                                                                                         
          Alteration, Focal                                                      1 (2%)       2 (4%)                                
      Renal Tubule, Epithelium, Degeneration,                                                                                       
          Multifocal                                                            49 (98%)     49 (98%)                               
      Renal Tubule, Epithelium, Hyperplasia, Focal                               6 (12%)     12 (24%)                               
      Renal Tubule, Epithelium, Hyperplasia,                                                                                        
          Multifocal                                                             6 (12%)      1 (2%)                                
      Renal Tubule, Epithelium, Karyomegaly,                                                                                        
          Multifocal                                                8 (16%)     50 (100%)    50 (100%)                              
      Renal Tubule, Epithelium, Pigmentation,                                                                                       
          Diffuse                                      1 (2%)                                                                       
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Focal                                                                 1 (2%)       7 (14%)                               
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Multifocal                                                            2 (4%)       9 (18%)                               
   Urinary Bladder                                    (50)         (27)         (15)         (50)                                   
      Calculus Gross Observation                                                 1 (7%)                                             
      Ectasia                                                                    2 (13%)                                            
      Hemorrhage                                                    1 (4%)                                                          
      Inflammation, Acute                                           1 (4%)                                                          
      Mucosa, Hyperplasia, Diffuse                                               1 (7%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           80           80           80                                     
  Scheduled Sacrifice                                 30           29           29           30                                     
  Early Deaths                                                                                                                      
    Gavage Death                                       4            6            2            1                                     
    Moribund                                           7           13           14           23                                     
    Dead                                                            6            9            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           26           26           23                                     
  Animals Examined Microscopically                    50           51           51           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (23)         (20)         (50)                                   
      Inflammation, Chronic Active, Diffuse                                      1 (5%)                                             
   Intestine Large, Colon                             (50)         (25)         (24)         (50)                                   
      Parasite Metazoan                                1 (2%)                                 2 (4%)                                
   Intestine Large, Rectum                            (48)         (23)         (24)         (47)                                   
      Parasite Metazoan                                6 (13%)      2 (9%)                    3 (6%)                                
   Intestine Small, Duodenum                          (50)         (25)         (23)         (50)                                   
      Necrosis, Acute, Focal                                                                  1 (2%)                                
   Liver                                              (50)         (26)         (26)         (50)                                   
      Angiectasis, Multifocal                                                                 1 (2%)                                
      Basophilic Focus, Multiple                      40 (80%)     13 (50%)      8 (31%)     33 (66%)                               
      Clear Cell Focus                                 9 (18%)                                6 (12%)                               
      Clear Cell Focus, Multiple                                                              1 (2%)                                
      Congestion                                       1 (2%)       1 (4%)                                                          
      Cytoplasmic Alteration, Focal                                              1 (4%)       2 (4%)                                
      Degeneration, Cystic, Focal                      2 (4%)       1 (4%)       1 (4%)       1 (2%)                                
      Eosinophilic Focus                                                                      2 (4%)                                
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)                                 1 (2%)                                
      Inflammation, Chronic Active, Multifocal         8 (16%)      1 (4%)                    3 (6%)                                
      Mixed Cell Focus                                              1 (4%)                                                          
      Necrosis, Acute                                  1 (2%)       5 (19%)      1 (4%)       1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Bile Duct, Hyperplasia, Multifocal              38 (76%)     16 (62%)     14 (54%)     30 (60%)                               
      Centrilobular, Vacuolization Cytoplasmic,                                                                                     
           Diffuse                                    23 (46%)      5 (19%)      2 (8%)      13 (26%)                               
      Periportal, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                                   1 (4%)       1 (4%)       1 (2%)                                
   Mesentery                                          (1)          (7)          (5)          (11)                                   
      Inflammation, Chronic Active                                  3 (43%)      4 (80%)      3 (27%)                               
   Pancreas                                           (50)         (26)         (24)         (50)                                   
      Inflammation, Acute, Multifocal                                                         1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic, Diffuse                   1 (2%)                                 1 (2%)                                
      Acinus, Atrophy                                 17 (34%)      8 (31%)      1 (4%)      14 (28%)                               
      Acinus, Focal Cellular Change                    6 (12%)                                5 (10%)                               
      Acinus, Hyperplasia, Focal                       6 (12%)                   2 (8%)       8 (16%)                               
      Duct, Ectasia, Multifocal                        1 (2%)                                                                       
      Perivascular, Inflammation, Chronic Active,                                                                                   
           Multifocal                                               1 (4%)                    3 (6%)                                
   Salivary Glands                                    (50)         (26)         (25)         (49)                                   
      Acinus, Atrophy, Multifocal                                                             2 (4%)                                
   Stomach, Forestomach                               (50)         (25)         (25)         (50)                                   
      Acanthosis                                                    1 (4%)                    8 (16%)                               
      Acanthosis, Focal                                1 (2%)                                 1 (2%)                                
      Acanthosis, Multifocal                                                                  1 (2%)                                
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Erosion                                                                                 1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       2 (8%)       2 (8%)       6 (12%)                               
      Ulcer                                            1 (2%)       2 (8%)       2 (8%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (25)         (25)         (49)                                   
      Hyperplasia, Multifocal                                                                 1 (2%)                                
      Inflammation, Acute                                           1 (4%)                                                          
      Ulcer                                                                                   4 (8%)                                
   Tongue                                                          (3)          (2)          (2)                                    
      Epithelium, Hyperkeratosis, Focal                                                       1 (50%)                               
      Epithelium, Hyperplasia                                       1 (33%)                   2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (26)         (25)         (50)                                   
      Degeneration, Chronic, Multifocal               47 (94%)     26 (100%)    22 (88%)     47 (94%)                               
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Epicardium, Fibrosis, Multifocal                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (25)         (25)         (50)                                   
      Cytoplasmic Alteration                                                     1 (4%)       1 (2%)                                
      Degeneration                                                                            2 (4%)                                
      Degeneration, Fatty                              6 (12%)      2 (8%)       3 (12%)     12 (24%)                               
      Hyperplasia                                     18 (36%)      3 (12%)      2 (8%)      13 (26%)                               
      Hyperplasia, Multifocal                                                                 1 (2%)                                
      Hypertrophy                                      5 (10%)                   1 (4%)       2 (4%)                                
      Bilateral, Atrophy, Diffuse                                                1 (4%)                                             
   Adrenal Gland, Medulla                             (50)         (25)         (26)         (49)                                   
      Hyperplasia                                      7 (14%)      2 (8%)       4 (15%)     10 (20%)                               
      Hyperplasia, Focal                                                                      1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (50)         (26)         (26)         (50)                                   
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (50)         (33)         (27)         (49)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (3%)       2 (7%)       3 (6%)                                
      Pars Distalis, Hyperplasia                       6 (12%)      4 (12%)      3 (11%)     14 (29%)                               
      Pars Intermedia, Cyst                            1 (2%)                                 1 (2%)                                
      Pars Nervosa, Hyperplasia                                                               1 (2%)                                
      Rathke's Cleft, Cyst, Multiple                                                          1 (2%)                                
   Thyroid Gland                                      (50)         (29)         (26)         (50)                                   
      C-Cell, Hyperplasia                             24 (48%)      6 (21%)     10 (38%)     16 (32%)                               
      Follicle, Cyst                                   1 (2%)                                 2 (4%)                                
      Follicular Cell, Hyperplasia                     1 (2%)                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)          (2)                                    
      Inflammation, Chronic Active, Diffuse                                                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (26)         (25)         (50)                                   
      Atrophy, Diffuse                                                           1 (4%)                                             
   Preputial Gland                                    (50)         (28)         (25)         (48)                                   
      Hyperplasia                                                   1 (4%)       1 (4%)                                             
      Inflammation, Chronic Active, Multifocal        44 (88%)     11 (39%)     11 (44%)     38 (79%)                               
      Duct, Ectasia                                    8 (16%)      1 (4%)                    3 (6%)                                
   Prostate                                           (50)         (26)         (25)         (50)                                   
      Atrophy, Diffuse                                                           1 (4%)                                             
      Cyst                                                                                    1 (2%)                                
      Dilatation, Diffuse                                                                     1 (2%)                                
      Inflammation, Acute                                           1 (4%)                                                          
      Inflammation, Chronic Active, Multifocal        15 (30%)      2 (8%)                   12 (24%)                               
      Epithelium, Hyperplasia, Multifocal                                        1 (4%)                                             
   Seminal Vesicle                                                 (1)                       (1)                                    
      Dilatation                                                    1 (100%)                                                        
      Inflammation, Acute                                           1 (100%)                                                        
   Testes                                             (50)         (50)         (48)         (50)                                   
      Inflammation, Chronic Active, Diffuse,                                                                                        
          Necrotizing                                                                         1 (2%)                                
      Germinal Epithelium, Atrophy                    43 (86%)      1 (2%)      40 (83%)     33 (66%)                               
      Interstitial Cell, Hyperplasia                  22 (44%)     13 (26%)     14 (29%)     24 (48%)                               
      Perivascular, Inflammation, Chronic,                                                                                          
          Multifocal                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                    (9)                                    
      Neutrophilia                                                                            5 (56%)                               
   Bone Marrow                                        (50)         (25)         (25)         (50)                                   
      Femoral, Hyperplasia, Diffuse, Neutrophil                     1 (4%)                    1 (2%)                                
   Lymph Node                                         (50)         (28)         (25)         (50)                                   
      Inguinal, Sinus, Ectasia                                      1 (4%)                                                          
      Lumbar, Sinus, Ectasia                                        1 (4%)                                                          
      Mediastinal, Congestion                                       1 (4%)                                                          
      Mediastinal, Hemorrhage, Multifocal                                                     1 (2%)                                
      Mesenteric, Cyst                                                                        1 (2%)                                
      Mesenteric, Inflammation, Chronic Active,                                                                                     
           Multifocal                                                                         1 (2%)                                
      Mesenteric, Sinus, Ectasia                                    1 (4%)                                                          
   Lymph Node, Mandibular                             (49)         (28)         (23)         (50)                                   
      Hemorrhage, Multifocal                                                                  2 (4%)                                
      Infiltration Cellular, Plasma Cell                            3 (11%)                   1 (2%)                                
      Necrosis, Acute, Multifocal                      1 (2%)                                                                       
   Spleen                                             (50)         (29)         (27)         (50)                                   
      Angiectasis                                                   1 (3%)                                                          
      Depletion Lymphoid                               3 (6%)       5 (17%)                                                         
      Infiltration Cellular, Multifocal, Lipocyte      1 (2%)                                                                       
      Red Pulp, Fibrosis                               2 (4%)       2 (7%)       1 (4%)       2 (4%)                                
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     3 (6%)       1 (3%)       1 (4%)       8 (16%)                               
      Red Pulp, Infiltration Cellular, Multifocal,                                                                                  
           Lipocyte                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (22)         (23)         (40)                                   
      Hyperplasia, Cystic, Multifocal                 37 (95%)     18 (82%)     18 (78%)     38 (95%)                               
   Skin                                               (49)         (32)         (30)         (49)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                1 (3%)       1 (3%)                                             
      Subcutaneous Tissue, Fibrosis                                 1 (3%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Diffuse                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (25)         (25)         (50)                                   
      Compression                                      1 (2%)       1 (4%)       1 (4%)       1 (2%)                                
      Ventricle, Hydrocephalus                         1 (2%)       2 (8%)       1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (30)         (27)         (50)                                   
      Congestion                                       2 (4%)                    2 (7%)                                             
      Edema, Acute, Diffuse                            3 (6%)                                                                       
      Foreign Body, Multifocal                        11 (22%)      9 (30%)      5 (19%)      6 (12%)                               
      Mineralization, Focal                            1 (2%)                                                                       
      Pigmentation                                                  2 (7%)                                                          
      Alveolar Epithelium, Hyperplasia                 3 (6%)       1 (3%)       2 (7%)       1 (2%)                                
      Interstitium, Inflammation, Acute, Multifocal                 2 (7%)       1 (4%)                                             
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                 21 (42%)      5 (17%)      2 (7%)      14 (28%)                               
      Perivascular, Edema, Acute                                    4 (13%)                                                         
   Nose                                               (50)         (25)         (24)         (50)                                   
      Lumen, Foreign Body                                                                     2 (4%)                                
      Nasolacrimal Duct, Hyperplasia                                             1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (1)          (4)          (2)                                    
      Lens, Cataract                                   3 (100%)     1 (100%)     2 (50%)      2 (100%)                              
      Retina, Atrophy, Diffuse                         3 (100%)     1 (100%)     2 (50%)      2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (51)         (51)         (50)                                   
      Cyst                                                                                    6 (12%)                               
      Cyst, Multiple                                                1 (2%)                    4 (8%)                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Hydronephrosis                                                1 (2%)                    1 (2%)                                
      Nephropathy, Chronic, Diffuse                   48 (96%)     51 (100%)    51 (100%)    48 (96%)                               
      Pelvis, Epithelium, Hyperplasia, Multifocal                                             1 (2%)                                
      Pelvis, Epithelium, Hyperplasia, Multifocal,                                                                                  
           Papillary                                                                          1 (2%)                                
      Renal Tubule, Hyperplasia                        1 (2%)                                                                       
      Renal Tubule, Epithelium, Cytoplasmic                                                                                         
          Alteration, Focal                            1 (2%)                    2 (4%)       7 (14%)                               
      Renal Tubule, Epithelium, Cytoplasmic                                                                                         
          Alteration, Multifocal                                                 1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05036-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 02:27:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 UG/KG      21 UG/KG     70 UG/KG     210 UG/                                   
                                                                                          KG                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Epithelium, Degeneration,                                                                                       
          Multifocal                                                            50 (98%)     49 (98%)                               
      Renal Tubule, Epithelium, Hyperplasia, Focal     1 (2%)                   11 (22%)     15 (30%)                               
      Renal Tubule, Epithelium, Hyperplasia,                                                                                        
          Multifocal                                                1 (2%)       5 (10%)      9 (18%)                               
      Renal Tubule, Epithelium, Karyomegaly,                                                                                        
          Multifocal                                                1 (2%)      51 (100%)    50 (100%)                              
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Focal                                                                 4 (8%)      13 (26%)                               
      Renal Tubule, Epithelium, Proliferation,                                                                                      
           Multifocal                                                            6 (12%)     13 (26%)                               
      Vein, Dilatation, Focal                          1 (2%)                                                                       
   Urethra                                                         (1)                                                              
      Calculus Micro Observation Only                               1 (100%)                                                        
   Urinary Bladder                                    (50)         (23)         (24)         (50)                                   
      Calculus Micro Observation Only                  2 (4%)                                 1 (2%)                                
      Ectasia                                                       1 (4%)                                                          
      Inflammation, Acute                                           1 (4%)                                                          
      Mucosa, Hyperplasia, Diffuse                                                            1 (2%)                                
      Serosa, Necrosis, Chronic Active, Multifocal                                            1 (2%)                                
      Submucosa, Inflammation, Chronic Active,                                                                                      
           Multifocal                                                                         1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 80678-80678/80678


--multipart-boundary--