Share This:
https://ntp.niehs.nih.gov/go/3080

TR 358 Rat Pathology Tables

NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 12:01:53




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  303-47-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|             
                                           | 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X        X     X     X  X  X  X  X  X  X           X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                            X           X                                 |             
      Eosinophilic Focus                   |                         X                                                |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       | 2     2              2  2           2                 2                 3|             
      Bile Duct, Hyperplasia, Multifocal   |                               2                       2                  |             
      Centrilobular, Degeneration          |             2                                   2                        |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |    2                                                                     |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                              3                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Inflammation, Chronic Active         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2              3  2     2                                      2  2     2|             
      Acinus, Degeneration, Multifocal     |                                                             2            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic, Multifocal    | 2              2  2  2  2  2  2                 2  2     2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|             
                                           | 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    3              2     2           2                                    |             
      Degeneration                         |                      3                                                   |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |             2                                                            |             
      Hyperplasia                          |                3        2  2  2                    2        2           2|             
      Hypertrophy                          |                                     2  2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X  X     X  X  X        X           X        X  X  X  X  X        X   |             
      Pars Distalis, Hyperplasia           |             3              2        2              3     3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     2           2  2  2  2  2     2        2     2     2  2        2  2|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lipocyte                         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                   3      |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|             
                                           | 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal, Reticulum   |                                                                          |             
          Cell                             |                3                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |          3                                               3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +|             
      Depletion Lymphoid, Multifocal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Cystic, Multifocal      | 3  3  2  3  3  2  3  3  3  3  4  3  3  3  2  4  3  3  3  3  3  3     3  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                  X           X                           |             
      Cyst                                 |                                           X                              |             
      Hemorrhage, Multifocal               |    3                                                                     |             
      Inflammation, Chronic, Multifocal    |                                           3                              |             
      Ventricle, Hydrocephalus             |                      3                       3                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body, Multifocal             |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               | 2     2              2  3  1        2  1           2  3     3  2     2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  | 2                                      2              2     2           2|             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       | 2                                      2              2                 3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +           +           +           +            |             
      Lens, Cataract                       |                                     3                       3            |             
      Retina, Atrophy, Diffuse             |                                     4                       4            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 6| 6| 7| 7| 2| 4| 5| 7| 7| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 9| 2| 2| 4| 2| 8| 2| 2| 2| 5| 6| 2| 2| 1| 6| 8| 2| 2| 2| 2| 2| 7| 2| 5|             
                                           | 8| 5| 8| 8| 8| 8| 9| 8| 8| 8| 4| 0| 8| 9| 6| 6| 3| 9| 9| 5| 9| 9| 3| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic, Diffuse        | 1     1  1  2        2  1  1  2  2  1  1     2     2  2     2  1     1  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation, Diffuse            |          3                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|             
                                           | 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X  X|             
      Clear Cell Focus                     |                   X                    X                                 |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |          2           2  2     2  2                             2  2  2   |             
      Bile Duct, Hyperplasia, Multifocal   | 3        2           2  2                 3     2  2        2  2  2     2|             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |             2                       3                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                   3  2                    2                 2     2      |             
      Acinus, Degeneration, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic, Multifocal    | 2     2  2           2     2  2  2  2  2  2  2  2  2  2  2  3  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|             
                                           | 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                2        2        3        2  2        2        2     2  3|             
      Degeneration                         |                                     2                                    |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hyperplasia                          |             2        2        2  2  2           2     2                  |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |          X                          X           X  X     X     X  X  X   |             
      Pars Distalis, Hyperplasia           | 2        2        3        3  2  3                 2           2  2  3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2  2  2              2        2        2  2        2        2  2|             
      Follicle, Cyst                       |                                                             X            |             
      Follicular Cell, Hyperplasia         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2     2                 2   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lipocyte                         |                                              3                           |             
      Duct, Cyst                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |          3           3        4                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|             
                                           | 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid, Multifocal       |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Multifocal      | 3  3     3  3  3  2  3  4  3     2  3  3  3  3  3  2     3  3  3  2  4  4|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             3                       3                       3            |             
      Cyst                                 |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Ventricle, Hydrocephalus             |             3                       3                       3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body, Multifocal             |       2                    1                 3                       2   |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               | 3     2  1  2     2  3     1     3     1  2     2  1  4  1  1  2  4      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                2                                      2                  |             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 9| 2| 2| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 7| 9| 3| 3| 3| 3| 3|             
                                           | 9| 7| 5| 9| 8| 0| 0| 0| 0| 0| 0| 0| 1| 0| 8| 1| 1| 1| 5| 5| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 UG/KG                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic, Diffuse        | 2        2  3  1  1  1  2        1  2  2  1     1  1  1     2  1  1      |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation, Diffuse            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Degeneration, Multifocal     |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Degeneration, Chronic, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Degeneration                         |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lipocyte                         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                                                                          |             
      Dilatation                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
      Depletion Lymphoid, Multifocal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
      Hyperplasia, Cystic, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Compression                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Foreign Body, Multifocal             |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 UG/KG                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Nephropathy, Chronic, Diffuse        |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation, Diffuse            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0 UG/KG                                | 3| 3| 3| 3| 3|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     41     |
      Clear Cell Focus                     |                                                                          |      4     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |     15  2.1|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |     13  2.2|
      Centrilobular, Degeneration          |                                                                          |      2  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  2.0|
      Periportal, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Acinus, Atrophy                      |                                                                          |     12  2.2|
      Acinus, Degeneration, Multifocal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0 UG/KG                                | 3| 3| 3| 3| 3|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Degeneration, Chronic, Multifocal    |                                                                          |     34  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Degeneration, Fatty                  |                                                                          |     13  2.2|
      Degeneration                         |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |     14  2.1|
      Hypertrophy                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Cyst                  |                                                                          |     21     |
      Pars Distalis, Hyperplasia           |                                                                          |     15  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     24  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      3  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lipocyte                         |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  49        |
      Periovarian Tissue, Cyst             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  49        |
      Dilatation                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0 UG/KG                                | 3| 3| 3| 3| 3|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Glandular, Multifocal           |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Pancreatic, Inflammation, Chronic    |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Hyperplasia, Multifocal, Reticulum   |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  43        |
      Depletion Lymphoid, Multifocal       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  47        |
      Hyperplasia, Cystic, Multifocal      |                                                                          |     46  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Femur, Hyperostosis                  |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      5  3.0|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  3.0|
      Ventricle, Hydrocephalus             |                                                                          |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Foreign Body, Multifocal             |                                                                          |      4  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8|                                                           |      A     |
    0 UG/KG                                | 3| 3| 3| 3| 3|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Active, Multifocal               |                                                                          |     30  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Lumen, Foreign Body                  |                                                                          |      7  2.0|
      Mucosa, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Lens, Cataract                       |                                                                          |      2  3.0|
      Retina, Atrophy, Diffuse             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Nephropathy, Chronic, Diffuse        |                                                                          |     35  1.5|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation, Diffuse            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|             
                                           | 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    21 UG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +           +  +  +        +  +     +  +  +  +           +  +   |             
      Basophilic Focus, Multiple           | X  X     X              X           X                             X  X   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                   2  2   |             
      Bile Duct, Hyperplasia, Multifocal   |    2     3                                                               |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                 2  3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
      Acinus, Atrophy                      | 2                                                     4                  |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
      Degeneration, Chronic, Multifocal    |    2                    2                       2  2              2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +           +  +  +           +     +  +  +  +  +        +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +           +  +  +           +     +  +  +  +  +        +  +   |             
      Degeneration, Fatty                  |    2                    2                       2                        |             
      Hyperplasia                          |    2     2                                                           2   |             
      Hypertrophy                          |                                                                          |             
      Necrosis, Acute                      |                                                    3                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +           +  +  +           +     +  +     +  +        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|             
                                           | 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    21 UG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +           M  +  +           M     M  +  +  M           M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +     +  +  +  +  +  +     +  +  +  +  +  +  +        +  +   |             
      Pars Distalis, Cyst                  |          X        X  X  X                          X                     |             
      Pars Distalis, Hyperplasia           |          3  2     2           2              3        3  2               |             
      Pars Nervosa, Hyperplasia, Glandular |                                                                          |             
      Rathke's Cleft, Cyst                 |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +           +  +  +           +     +  +  +  +  +        +  +   |             
      C-Cell, Hyperplasia                  | 2                       2  2                 2  2  2              2      |             
      Follicular Cell, Hyperplasia         |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +           +  +  +  +        +     +  +  +  +           +  +   |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Duct, Cyst                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +        +  +  +  +           +     +  +  +  +           +  +   |             
      Follicle, Cyst                       |                   X                                                      |             
      Periovarian Tissue, Cyst             |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +     +  +  +           +     +  +  +  +  +        +  +   |             
      Dilatation                           |                      3                                                   |             
      Inflammation, Chronic Active         |                         4                                                |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                            2                    2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
      Mesenteric, Sinus, Ectasia           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +           +  +              +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +           +  +  +     +     +     +  +  +  +           +  +   |             
      Depletion Lymphoid                   |                                        2                                 |             
      Red Pulp, Fibrosis                   |                                  1                                       |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +  +     +  +  +  +  +  +  +  +  +  +           +  +  +|             
      Hyperplasia, Cystic, Multifocal      | 3  3     2           2     3                 2  3  3  3           3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 7| 4| 4| 6| 7| 7| 7| 0| 7| 6| 6| 7| 6| 7| 7| 7| 6| 4| 7|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 2| 2| 1| 5| 7| 2| 2| 2| 0| 2| 3| 5| 1| 2| 2| 2| 2| 6| 5| 2|             
                                           | 5| 8| 8| 8| 8| 8| 8| 5| 2| 4| 8| 8| 9| 5| 9| 2| 8| 6| 6| 9| 9| 9| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    21 UG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +           +  +  +           +     +  +  +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
      Compression                          |                                                 3                 3      |             
      Ventricle, Hydrocephalus             |                                                 2                 3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +        +  +  +  +           +     +  +  +  +           +  +   |             
      Foreign Body, Multifocal             |                      2                 3                                 |             
      Alveolar Epithelium, Hyperplasia     |                   3                                                      |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               | 2  1                    2                             3              3   |             
      Perivascular, Edema, Acute           |                      3                 2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cornea, Hyperplasia                  |                                                                2         |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic, Diffuse        | 1  4  1           2  1  1  1  1  2  1     2  1  2  2  1  2  2  1  3      |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |    1  1     1  1     1        1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +           +  +  +           +     +  +  +  +           +  +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|             
                                           | 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    21 UG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
      Basophilic Focus, Multiple           |    X     X                 X           X     X  X        X  X            |             
      Cytoplasmic Alteration, Focal        |                                        3     2                           |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                 2                        |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                      2   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |    2  3                                                     2            |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                         4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +        +  +           +     +  +  +     +  +  +     +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                         4                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
      Inflammation, Chronic Active         |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
      Degeneration, Chronic, Multifocal    |                            2                                2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |          2     3                                2                        |             
      Hypertrophy                          |                2                       2                                 |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|             
                                           | 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    21 UG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M  +     +           +           +     M  +  M     +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +  +  +     +  +|             
      Pars Distalis, Cyst                  |             X        X              X                                X   |             
      Pars Distalis, Hyperplasia           |                                           3     2                        |             
      Pars Nervosa, Hyperplasia, Glandular |                                                             2            |             
      Rathke's Cleft, Cyst                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +     +     +           +     +  +  +  +  +  +  +     +  +|             
      C-Cell, Hyperplasia                  |       2                    2                 2  2  2           2     2   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +     +           +           +     +  +  +     +  +  +     +  M|             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
      Follicle, Cyst                       |                                                                X         |             
      Periovarian Tissue, Cyst             |                                                             X        X   |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +     +     +           +     +  +  +     +  +  +     +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |          3           3                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +     +           +           +     +  +  M     +  +  +     +  +|             
      Mesenteric, Sinus, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +     +           +           +     +  +  M     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +           +           +     +  +  +     +  +  +     +  I|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +        +  +     +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Multifocal      |    3  4  3     3           3           3           3     2  2  3     3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 7| 4| 5| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 1| 5| 4| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 7| 2| 3| 4| 6|             
                                           | 0| 6| 8| 6| 0| 4| 0| 0| 0| 5| 0| 1| 1| 7| 1| 2| 6| 8| 1| 6| 7| 4| 1| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    21 UG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +        +        +  +     +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
      Compression                          |    3  2  3                                   2                          3|             
      Ventricle, Hydrocephalus             |    3  3  2                                   3                          2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +           +  +        +     +  +  +  +  +  +  +     +  +|             
      Foreign Body, Multifocal             |          2                                      1        2               |             
      Alveolar Epithelium, Hyperplasia     | 2                             2                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                            2  3        2              3     2  2        2|             
      Perivascular, Edema, Acute           |                                                 3        2               |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +           +           +     +  +  +     +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cornea, Hyperplasia                  |                                                                          |             
      Lens, Cataract                       |                                                                         2|             
      Retina, Atrophy, Diffuse             |                                                                         2|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +     +           +           +     +  +  +     +  M  +     +  +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic, Diffuse        | 2  2  2  3  2     4  2  1  1  2        2  1  3  2  1  3        2  3  3  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |                                  1        1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +     +           +           +     +  +  +     M  +  +     +  +|             
      Hemorrhage                           |                                                    3                     |             
      Inflammation, Acute                  |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    21 UG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   |                +                                                         |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +                                                         |             
      Acinus, Atrophy                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +                                                         |             
      Degeneration, Chronic, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +                                                         |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    21 UG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                M                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +                                                         |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Nervosa, Hyperplasia, Glandular |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +                                                         |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +                                                         |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                +                                                         |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                                                         |             
      Mesenteric, Sinus, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +                                                         |             
      Depletion Lymphoid                   |                                                                          |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +                                                         |             
      Hyperplasia, Cystic, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    21 UG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                                                         |             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +                                                         |             
      Foreign Body, Multifocal             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Perivascular, Edema, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Hyperplasia                  |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +                                                         |             
      Nephropathy, Chronic, Diffuse        |                1                                                         |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +                                                         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    21 UG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  29        |
      Basophilic Focus, Multiple           |                                                                          |     15     |
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.5|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      3  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |      3  2.3|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      3  2.3|
      Periportal, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  29        |
      Acinus, Atrophy                      |                                                                          |      2  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  28        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  28        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  28        |
      Degeneration, Chronic, Multifocal    |                                                                          |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  29        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  29        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    21 UG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Fatty                  |                                                                          |      3  2.0|
      Hyperplasia                          |                                                                          |      6  2.2|
      Hypertrophy                          |                                                                          |      2  2.0|
      Necrosis, Acute                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  27        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  41        |
      Pars Distalis, Cyst                  |                                                                          |      9     |
      Pars Distalis, Hyperplasia           |                                                                          |      9  2.4|
      Pars Nervosa, Hyperplasia, Glandular |                                                                          |      1  2.0|
      Rathke's Cleft, Cyst                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  32        |
      C-Cell, Hyperplasia                  |                                                                          |     14  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  29        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  29        |
      Follicle, Cyst                       |                                                                          |      2     |
      Periovarian Tissue, Cyst             |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  32        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  27        |
      Mesenteric, Sinus, Ectasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  26        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    21 UG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  29        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Red Pulp, Fibrosis                   |                                                                          |      1  1.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  27        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  40        |
      Hyperplasia, Cystic, Multifocal      |                                                                          |     22  2.8|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  31        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  28        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  28        |
      Compression                          |                                                                          |      7  2.7|
      Ventricle, Hydrocephalus             |                                                                          |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  32        |
      Foreign Body, Multifocal             |                                                                          |      5  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.3|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |     12  2.3|
      Perivascular, Edema, Acute           |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  28        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  28        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Hyperplasia                  |                                                                          |      1  2.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
      Retina, Atrophy, Diffuse             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  27        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9|                                                           |      A     |
    21 UG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  51        |
      Nephropathy, Chronic, Diffuse        |                                                                          |     40  1.9|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Karyomegaly, Multifocal          |                                                                          |      8  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  27        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|             
                                           | 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |          +  +  +  +        +     +     +                    +     +  +   |             
      Basophilic Focus, Multiple           |          X     X  X              X     X                          X  X   |             
      Cytoplasmic Alteration, Focal        |                2                                                         |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                  2                                       |             
      Bile Duct, Hyperplasia, Multifocal   |                                        2                    3            |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +              +     +     +                    +     +  +   |             
      Acinus, Atrophy                      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Epithelium, Hyperkeratosis, Focal    |                                                                         2|             
      Epithelium, Hyperplasia              |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +              +     +     +                    +     +  +   |             
      Degeneration, Chronic, Multifocal    |             2              2     2     2                    2     2  3   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +              +     +     +                    +     +  +   |             
      Accessory Adrenal Cortical Nodule    |                                                                      X   |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty                  |                            2                                2            |             
      Necrosis, Acute                      |                                  2     2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +              +     +     +                    +     +  +   |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +              +     M     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +  +     +  +  +  +  +  +     +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|             
                                           | 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  | X           X                             X                    X         |             
      Pars Distalis, Hyperplasia           |                               3  2  3  3                             3  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +  +           +     +     +                    +  +  +  +   |             
      C-Cell, Hyperplasia                  |             2              2     2                          2     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +     +              +     +     +  +                 M     +  +   |             
      Inflammation, Chronic Active         |       3                                                              2   |             
      Duct, Hyperplasia, Multifocal,       |                                                                          |             
          Squamous                         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +     +              +     +     +        +           +     +  +   |             
      Periovarian Tissue, Cyst             |       X                                         X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +           +  +     +     +              +     +     +  +   |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +              +     +     +                    +     +  +   |             
      Lumbar, Cyst                         |                                                                          |             
      Lumbar, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +              +     +     +                    +     +  +   |             
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +              +     +  +  +                    +     +  +   |             
      Degeneration, Fatty, Focal           |                                     3                                    |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +              +     +     +                    +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +  +        +  +  +  +     +  +     +  +     +  +     +  +  +|             
      Hyperplasia, Cystic, Multifocal      |       4     3              3     3     3  3     4           3     3  3   |             
                                            __________________________________________________________________________|             
   Skin                                    |             +        +     +     +     +                    +     +  +   |             
      Acanthosis, Multifocal               |                      2                                                   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +              +     +     +                    +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|             
                                           | 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +              +     +     +                    +     +  +   |             
      Compression                          |                                                                   X      |             
      Ventricle, Hydrocephalus             |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +              +     +  +  +                    +     +  +   |             
      Foreign Body, Multifocal             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                  3  2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +              +     +     +                    +     +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                       +           +            |             
      Lens, Cataract                       |                         3                       4           4            |             
      Retina, Atrophy, Diffuse             |                         4                       4           4            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +              +     +     +                    +     +  +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Hydronephrosis                       |             3                                                            |             
      Mineralization, Multifocal           |                                                                      3   |             
      Nephropathy, Chronic, Diffuse        | 1  1  1  2  1  2  1  4  2  1  1  1  1  1  1  1  2  1           1  2  3  2|             
      Cortex, Hemorrhage, Focal            |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         | 2  2  2  3  2  2  2  2  2  2  2  1  2  1  1  2  2  2  2  1  2  2  2  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |    2        2                          2                          2      |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |       2  2              2                    2           2  2            |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          | 2  2  2  2  2  2  2  2  2  1  2  1  2  1  1  2  2  2  3  2  2  2  2  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |                      2                          2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +              +     +     +                    +     +  +   |             
      Calculus Gross Observation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 6| 2| 5| 2| 2| 2| 2| 2| 2| 6| 2| 8| 9| 3|             
                                           | 8| 8| 8| 8| 6| 8| 8| 8| 8| 7| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |             4                                                            |             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|             
                                           | 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +           +     +        A     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +           +     +        A     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +           +     +        A     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +           +     +        A     +                    +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +        +           +     +        +     +     +              +     +|             
      Basophilic Focus, Multiple           |    X                                         X                    X     X|             
      Cytoplasmic Alteration, Focal        |                                                    3                     |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                         2                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +           +     +        A     +                    +     +|             
      Acinus, Atrophy                      |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperkeratosis, Focal    |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +           +     +        +     +                    +     +|             
      Degeneration, Chronic, Multifocal    |                               2              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +           +     +        +     +              +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +           +     +        +     +                    +     +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty, Focal           |                         2                                                |             
      Degeneration, Fatty                  |    4                          2              2                           |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +                    +     +        +     +              +     +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +           +     +        A     +                    +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +           +     +        +     M                    +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +        +  +     +  +  +  +  +  +  +  +     +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|             
                                           | 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                               X  X        X              X              X|             
      Pars Distalis, Hyperplasia           |                                           3                       3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +        +           +     +        +     +              +     +     +|             
      C-Cell, Hyperplasia                  |    2                    2     3              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    M        +           +     +        +     M        +  +  +     +     +|             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Hyperplasia, Multifocal,       |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        +           +     +        +     +        +           +     +|             
      Periovarian Tissue, Cyst             | X                                                     X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +        +        +  +     +        +  +  +                    +     +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                      3                    3                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +           +     +        +     +           +        +     +|             
      Lumbar, Cyst                         |                                                          X               |             
      Lumbar, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +        +           +     +        +     +                    +     +|             
      Hyperplasia, Lymphoid, Multifocal    |                         3                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +           +     +        +     +                    +     +|             
      Degeneration, Fatty, Focal           |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M        M           +     +        M     M                    +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  +  +     M  +  +     +  +     +     +  +  +     +  +  +  +|             
      Hyperplasia, Cystic, Multifocal      |    3        2                 3     4        3                    2     2|             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +           +     +        +     +                    +     +|             
      Acanthosis, Multifocal               |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +           +     +        +     +                    +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|             
                                           | 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +           +     +        +     +                    +     +|             
      Compression                          |                                              X                           |             
      Ventricle, Hydrocephalus             |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +           +     +     +  +     +                    +     +|             
      Foreign Body, Multifocal             |                                        2                                 |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |    2  3                 3     3     3        2                           |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +           +     +        +     +                    +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +           +     +        +     +                    +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +        +                                       |             
      Lens, Cataract                       |                         3        3                                       |             
      Retina, Atrophy, Diffuse             |                         4        3                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +        +           +     +        M     +                    +     +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                               +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Nephropathy, Chronic, Diffuse        | 1  2  1  1  1  1  1  1     2  1  2  2     2  3  1  3  1  1  2  1  1  1   |             
      Cortex, Hemorrhage, Focal            |                                        3                                 |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                            2                                             |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         | 2  1  1  2  1  2  2  1  1  2  2  2  2     2  2  2  2  2  2  2  1  1  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |    2                                                     2               |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          | 2  1  1  2  1  2  2  1  1  2  2  2  2  2  2  2  2  2  2  2  2  1  1  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |                                                       2                  |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +           +     +        +     +                    +     +|             
      Calculus Gross Observation           |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 3| 7| 7| 7| 4| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 6| 3| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 3| 3| 6| 3| 0|             
                                           | 0| 7| 0| 0| 9| 0| 0| 0| 6| 0| 2| 0| 1| 0| 1| 5| 1| 1| 1| 1| 1| 1| 4| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    70 UG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                               4                                          |             
      Mucosa, Hyperplasia, Diffuse         |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperkeratosis, Focal    |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Degeneration, Chronic, Multifocal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Hyperplasia, Multifocal,       |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Lumbar, Cyst                         |                                                                          |             
      Lumbar, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                                          |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
      Hyperplasia, Cystic, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
      Acanthosis, Multifocal               |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Foreign Body, Multifocal             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Nephropathy, Chronic, Diffuse        |                                                                          |             
      Cortex, Hemorrhage, Focal            |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
      Calculus Gross Observation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    70 UG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    70 UG/KG                               | 5| 5| 5| 5| 5|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  19        |
      Basophilic Focus, Multiple           |                                                                          |     11     |
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.5|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |      2  2.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  14        |
      Acinus, Atrophy                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperkeratosis, Focal    |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  15        |
      Degeneration, Chronic, Multifocal    |                                                                          |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  15        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Degeneration, Fatty, Focal           |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      5  2.4|
      Necrosis, Acute                      |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    70 UG/KG                               | 5| 5| 5| 5| 5|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  15        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  35        |
      Pars Distalis, Cyst                  |                                                                          |      9     |
      Pars Distalis, Hyperplasia           |                                                                          |      8  2.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  18        |
      C-Cell, Hyperplasia                  |                                                                          |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  17        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Duct, Hyperplasia, Multifocal,       |                                                                          |            |
          Squamous                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  19        |
      Periovarian Tissue, Cyst             |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  19        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  16        |
      Lumbar, Cyst                         |                                                                          |      1     |
      Lumbar, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  15        |
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  16        |
      Degeneration, Fatty, Focal           |                                                                          |      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    70 UG/KG                               | 5| 5| 5| 5| 5|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  34        |
      Hyperplasia, Cystic, Multifocal      |                                                                          |     17  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  16        |
      Acanthosis, Multifocal               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Diffuse         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  15        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  15        |
      Compression                          |                                                                          |      2     |
      Ventricle, Hydrocephalus             |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  18        |
      Foreign Body, Multifocal             |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      8  2.6|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  15        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Lens, Cataract                       |                                                                          |      5  3.4|
      Retina, Atrophy, Diffuse             |                                                                          |      5  3.8|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Cyst                                 |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |      1  3.0|
      Nephropathy, Chronic, Diffuse        |                                                                          |     44  1.5|
      Cortex, Hemorrhage, Focal            |                                                                          |      1  3.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    70 UG/KG                               | 5| 5| 5| 5| 5|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Cytoplasmic Alteration, Focal    |                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Degeneration, Multifocal         |                                                                          |     49  1.8|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Focal               |                                                                          |      6  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Multifocal          |                                                                          |      6  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Karyomegaly, Multifocal          |                                                                          |     50  1.8|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Proliferation, Focal             |                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  15        |
      Calculus Gross Observation           |                                                                          |      1     |
      Ectasia                              |                                                                          |      2  4.0|
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|             
                                           | 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X  X     X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X   |             
      Cytoplasmic Alteration, Focal        |          2                 2                                         2   |             
      Cytoplasmic Alteration, Multifocal   |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |             2              3     2                                       |             
      Necrosis, Acute                      |       4                                                                  |             
      Regeneration, Focal                  |                   3                                                      |             
      Bile Duct, Hyperplasia, Multifocal   | 2        2     3              2     2     2        2  2     2  2  2      |             
      Periportal, Fibrosis, Chronic,       |                                                                          |             
          Multifocal                       |                3                                                         |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2  2     4              2              2           2  2        2   |             
      Acinus, Focal Cellular Change        |                                                                          |             
      Duct, Ectasia                        |                            2                 2              2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               4                                          |             
      Ulcer                                |                               4                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic, Multifocal    | 2  3  3  2  3  2  3  2  3  2  2  2  3  2  2  3  2  3  2  3  2  3  2      |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|             
                                           | 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Degeneration, Fatty                  |          2     2  2                                2                     |             
      Hyperplasia                          |    2                 2                    2           2     2     2      |             
      Hypertrophy                          | 2                                               2                        |             
      Necrosis, Acute                      |             3           2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2           2                          2        2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | X  X              X           X              X  X  X           X  X  X  X|             
      Pars Distalis, Hyperplasia           | 3                                         3  3     3  2           2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2        2     2           2  2  2        2  2     2  2     3  2     2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                                      2     3        2         |             
      Inflammation, Chronic Active         |                                        2  2  3              2     3      |             
      Duct, Cyst                           |                                              X                           |             
      Duct, Hyperplasia, Multifocal,       |                                                                          |             
          Squamous                         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Diffuse                       |                4                                                         |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                  2                          2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Reticulum Cell | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|             
                                           | 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Diffuse                       |                4                                                         |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Multifocal      | 3  3  4  2  3  2  4  4     3  4  3  3     3  3  4  4  4  4  3  3  2  4  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         3                                                |             
      Ventricle, Hydrocephalus             |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body, Multifocal             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     3                                    |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               | 1           1  2           3  2     3           2  4  1  2  1  2     2   |             
      Perivascular, Edema, Acute           |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                   3           3                                          |             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                   2           3                                         2|             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                 +  +                                                |             
      Lens, Cataract                       |    4                 3  4                                                |             
      Retina, Atrophy, Diffuse             |    4                 4  4                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 6| 2| 2| 1| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 3| 0|             
                                           | 8| 8| 8| 8| 0| 8| 8| 1| 3| 8| 8| 8| 8| 0| 9| 9| 9| 9| 9| 9| 0| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X  X        X     X     X        X  X     X  X  X  X   |             
      Cyst, Multiple                       | X  X                                         X                           |             
      Nephropathy, Chronic, Diffuse        | 3  2  2  4  1  3  2  2     3  2  2  2     2  2  1  2  1  2  2  3  2  2   |             
      Pelvis, Epithelium, Hyperplasia,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                2  2                                                      |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         | 3  3  3  3  2  3  3  3  3  3  3  3  3  2  3  3  3  3  3  3  3  3  3  3  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |       2              2           2                       2  2     2      |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |          2                                                               |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             | 2                    2           2                                   2   |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |       2  2                 2                 2           2  2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|             
                                           | 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    210 UG/                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X  X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Cytoplasmic Alteration, Focal        |                                                                      2   |             
      Cytoplasmic Alteration, Multifocal   |                                                          2               |             
      Eosinophilic Focus                   |                                        X                                 |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       | 2                 2           2                                2     2   |             
      Necrosis, Acute                      |                                                                          |             
      Regeneration, Focal                  |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |             2           2           2     2  3           3              3|             
      Periportal, Fibrosis, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Inflammation, Chronic Active         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2                       2           2        2        2              2   |             
      Acinus, Focal Cellular Change        |                                                                         X|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic, Multifocal    | 2  2  3  2  2     2  2  3  2     2     2  2  2     2  3  2  2  2         |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|             
                                           | 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    210 UG/                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |       4                                                                  |             
      Degeneration, Fatty                  |    2     3  2  2                 2                       2  2        2  2|             
      Hyperplasia                          |          2                                2  2  2     2  2  2            |             
      Hypertrophy                          |             2                                                            |             
      Necrosis, Acute                      |                            4                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2  2        2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |          X           X              X  X                    X           X|             
      Pars Distalis, Hyperplasia           |                   3  2  3     3  3     2  3     3           3           2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2           2  2  2  2        2     2  2  2  2  2        2     2        2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                       2  3        2                  |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Duct, Cyst                           |                                                                          |             
      Duct, Hyperplasia, Multifocal,       |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Diffuse                       |                                                                          |             
      Follicle, Cyst                       |                                     X           X                        |             
      Periovarian Tissue, Cyst             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Reticulum Cell |                                                          4               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|             
                                           | 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    210 UG/                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Diffuse                       |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |    3  3              3                          3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  I  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Multifocal      | 3  4  4  3  4  2  3  2  2  3  3  4  2  4  4  4  3  3  3  3  3  4  2  3  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    2           2         |             
      Ventricle, Hydrocephalus             |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body, Multifocal             | 1                                               2                        |             
      Alveolar Epithelium, Hyperplasia     |             2           3                                   2            |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |             1     1  1  3     2  1  1  4        2     3           1      |             
      Perivascular, Edema, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                         2        2  2              2                     |             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |       3                                      2                           |             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                         2                          3                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Multifocal               |                                                             2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Lens, Cataract                       |             3                                                            |             
      Retina, Atrophy, Diffuse             |             4                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 3| 3| 4| 3| 3| 3| 3| 6| 1| 3| 3|             
                                           | 0| 0| 9| 0| 0| 6| 0| 6| 0| 0| 0| 9| 0| 1| 1| 1| 5| 1| 1| 1| 1| 0| 5| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    210 UG/                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X     X        X  X  X           X  X  X     X  X        X  X        X|             
      Cyst, Multiple                       |                                              X        X  X               |             
      Nephropathy, Chronic, Diffuse        | 2  1  2  1  1  1     1  2  2  1  2  1  1  1  2  1  1  2  3  3  2  2  2  2|             
      Pelvis, Epithelium, Hyperplasia,     |                                                                          |             
           Multifocal                      |                2                                            3            |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         | 3  3  3  3  3  2  3  3  3  2     4  3  3  2  3  3  3  3  3  3  3  3  2  3|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               | 2        2           2              2     2                          2   |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |                               2  2                 2                     |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        | 2           2                                            2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Cytoplasmic Alteration, Multifocal   |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
      Regeneration, Focal                  |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Periportal, Fibrosis, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Focal Cellular Change        |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
      Acinus, Atrophy, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Degeneration, Chronic, Multifocal    |                                                                          |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
      Atrophy, Diffuse                     |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Cyst                           |                                                                          |             
      Duct, Hyperplasia, Multifocal,       |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                                                                          |             
      Edema, Diffuse                       |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid,   |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                                          |             
      Edema, Diffuse                       |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
      Hyperplasia, Cystic, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Foreign Body, Multifocal             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Perivascular, Edema, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Mucosa, Inflammation, Chronic Active,|                                                                          |             
           Multifocal                      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    210 UG/                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Cyst                                 |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Nephropathy, Chronic, Diffuse        |                                                                          |             
      Pelvis, Epithelium, Hyperplasia,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
      Mucosa, Hyperplasia, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    210 UG/                                | 1| 1| 1| 1| 1|                                                           |      L     |
    KG                                     | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  47        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     45     |
      Cytoplasmic Alteration, Focal        |                                                                          |      4  2.0|
      Cytoplasmic Alteration, Multifocal   |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      8  2.1|
      Necrosis, Acute                      |                                                                          |      1  4.0|
      Regeneration, Focal                  |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |     18  2.2|
      Periportal, Fibrosis, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Periportal, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Acinus, Atrophy                      |                                                                          |     14  2.1|
      Acinus, Focal Cellular Change        |                                                                          |      1     |
      Duct, Ectasia                        |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Acinus, Atrophy, Focal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    210 UG/                                | 1| 1| 1| 1| 1|                                                           |      L     |
    KG                                     | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Degeneration, Chronic, Multifocal    |                                                                          |     41  2.3|
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
      Degeneration, Fatty                  |                                                                          |     13  2.1|
      Hyperplasia                          |                                                                          |     13  2.0|
      Hypertrophy                          |                                                                          |      3  2.0|
      Necrosis, Acute                      |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  49        |
      Pars Distalis, Cyst                  |                                                                          |     17     |
      Pars Distalis, Hyperplasia           |                                                                          |     16  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     27  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |  47        |
      Hyperplasia                          |                                                                          |      8  2.3|
      Inflammation, Chronic Active         |                                                                          |      6  2.3|
      Duct, Cyst                           |                                                                          |      1     |
      Duct, Hyperplasia, Multifocal,       |                                                                          |            |
          Squamous                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  50        |
      Edema, Diffuse                       |                                                                          |      1  4.0|
      Follicle, Cyst                       |                                                                          |      2     |
      Periovarian Tissue, Cyst             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    210 UG/                                | 1| 1| 1| 1| 1|                                                           |      L     |
    KG                                     | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mesenteric, Hyperplasia, Lymphoid,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Edema, Diffuse                       |                                                                          |      1  4.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  49        |
      Hyperplasia, Cystic, Multifocal      |                                                                          |     48  3.2|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Femur, Osteopetrosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      3  2.3|
      Ventricle, Hydrocephalus             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Foreign Body, Multifocal             |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.5|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |     24  1.9|
      Perivascular, Edema, Acute           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Lumen, Foreign Body                  |                                                                          |      6  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    210 UG/                                | 1| 1| 1| 1| 1|                                                           |      L     |
    KG                                     | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                                                                          |      5  2.4|
      Mucosa, Inflammation, Chronic Active,|                                                                          |            |
           Multifocal                      |                                                                          |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Multifocal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Lens, Cataract                       |                                                                          |      4  3.5|
      Retina, Atrophy, Diffuse             |                                                                          |      4  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Cyst                                 |                                                                          |     25     |
      Cyst, Multiple                       |                                                                          |      6     |
      Nephropathy, Chronic, Diffuse        |                                                                          |     46  1.9|
      Pelvis, Epithelium, Hyperplasia,     |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.5|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Cytoplasmic Alteration, Focal    |                                                                          |      2  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Degeneration, Multifocal         |                                                                          |     49  2.9|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Focal               |                                                                          |     12  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Multifocal          |                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Karyomegaly, Multifocal          |                                                                          |     50  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Proliferation, Focal             |                                                                          |      7  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      9  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X              X                    X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           | X        X  X     X  X     X  X  X  X  X  X     X  X     X  X  X  X  X  X|             
      Clear Cell Focus                     |                      X                             X           X         |             
      Congestion                           |       4                                                                  |             
      Degeneration, Cystic, Focal          |                   2                                                      |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2                                                        2               |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                   2              2  2     2                          2  2|             
      Necrosis, Acute                      |                                              2                           |             
      Bile Duct, Hyperplasia, Multifocal   | 3  3     2  2     2  2     3  2  3  3  2  2     2  3  3     2  3  2  2  2|             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                2        2        2  2     2  2     2     2     2     2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       | 2                                                                        |             
      Acinus, Atrophy                      |          2              2        2  2        2                    2  2   |             
      Acinus, Focal Cellular Change        |                                  X  X  X  X                       X      |             
      Acinus, Hyperplasia, Focal           |                                           2                 3  2     3   |             
      Duct, Ectasia, Multifocal            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic, Multifocal    | 3  2  2  3  3     3  2  2  2  3  3  3  2  3  1  2  3  2  3  3  3  2  2  2|             
      Inflammation, Chronic, Focal         |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |          2  2     2                                                      |             
      Hyperplasia                          | 2                          2  2        2  2           2     2        2   |             
      Hypertrophy                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2        2                       3                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                         X|             
      Pars Distalis, Hyperplasia           |                                        2                                 |             
      Pars Intermedia, Cyst                |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2              2        2  2  2        2        2  2  2     2  2  2  2|             
      Follicle, Cyst                       |                            X                                             |             
      Follicular Cell, Hyperplasia         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       | 2  3  2  2  2     2  2     3     2  3  3  2     2  2  2  2  3  3  2  2  3|             
      Duct, Ectasia                        |             3  3                 3           4                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       | 2        2  2                 2                    2           1  2  2  3|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 4  4     3  4     4  4     4  4  4  4  3  4     4  4  4  4  3  4  4  4  3|             
      Interstitial Cell, Hyperplasia       | 2  2  2  2  2     2  2  2        2                 2        2        2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Acute, Multifocal          |                2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |       3        2                             2                           |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lipocyte                        |                                  3                                       |             
      Red Pulp, Fibrosis                   |                   3              2                                       |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  M  +  +|             
      Hyperplasia, Cystic, Multifocal      | 3           3  3  3  2  2  3     2  2  3        2  3  2     2  2     3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                   X                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                                      3                           |             
      Edema, Acute, Diffuse                |                3        2                    3                           |             
      Foreign Body, Multifocal             |       3        3     2  3                 2  2                          2|             
      Mineralization, Focal                |             2                                                            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |    2              2  2           2  3  3           2  3        3  3     3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                    +   |             
      Lens, Cataract                       |                                                 4                    4   |             
      Retina, Atrophy, Diffuse             |                                                 4                    4   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 0| 7| 7| 3| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 1| 2| 2| 7| 2| 2| 2| 2| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3|             
                                           | 9| 9| 6| 9| 9| 0| 9| 9| 7| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic, Diffuse        | 4  3  3  2  3     3  2  2  2  2  2  3  2  4     2  2  4  3  2  3  2  4  4|             
      Renal Tubule, Hyperplasia            |             2                                                            |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |                                                                          |             
      Vein, Dilatation, Focal              |       4                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                               X        X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |       X  X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |       X  X     X           X  X                                      X   |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic, Focal          |                                                    2                     |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                     2                          2         |             
      Necrosis, Acute                      |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   | 4  3  3  3     2     3  2  3     2  2  3  3  3     3  3     2     2  2   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |          2  2     2                 2           2  2  2  2  2     2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Acinus, Atrophy                      |       2           2        2           2  3  2  2  2  2                 2|             
      Acinus, Focal Cellular Change        |                      X                                                   |             
      Acinus, Hyperplasia, Focal           |          2           2                                                   |             
      Duct, Ectasia, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                  1                                       |             
      Inflammation, Chronic Active         |                                  2                                       |             
      Ulcer                                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic, Multifocal    | 3  2  3  3     2  3  2  3  3  2  2  3  3  2     2  2  2  2  2  2  3  2  2|             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                             3     2     2|             
      Hyperplasia                          |    2     2  2     3                 2        2  2  2  3                 2|             
      Hypertrophy                          |                                  2     2           2                 2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2           2                                2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       3        2        2     2     2                                    |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     2     2  2  2  2                 2     2  2              2        2|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       | 3  2  2  3  2  3  2  2  2  2     2  3  3  2  3  2  3  3  3  3  2  2  2   |             
      Duct, Ectasia                        |                   4              3        3     3                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                   3              2           2     3  3        2         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 3  4  4  4  3  4     4     4  4  3  4  4  4  3  4  3  4     4  4  3  3  3|             
      Interstitial Cell, Hyperplasia       | 2           2     2     3     2  2        2              2     2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Acute, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lipocyte                        |                                                                          |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |             3                                            3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Multifocal      | 3  2  2  2  3     4  2  3     3  3     2  3  3  2     1  3  2  4  3  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                  4                                       |             
      Ventricle, Hydrocephalus             |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema, Acute, Diffuse                |                                                                          |             
      Foreign Body, Multifocal             |    3                                   3        3  2                     |             
      Mineralization, Focal                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              2              2           3|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |    3     3     3  2        3           2        3  3  2                 3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Lens, Cataract                       |                4                                                         |             
      Retina, Atrophy, Diffuse             |                4                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 4| 3| 9| 0| 3| 3| 1| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 0| 1| 1| 4| 1| 1| 6| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic, Diffuse        | 3  3  3  3  3  4  3  1  2  3  2  4  2  3  2  3  3  2  2  2  2  2  2  2  2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |             2                                                            |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |                   2                                                      |             
      Vein, Dilatation, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Focal Cellular Change        |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Duct, Ectasia, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
      Acanthosis, Focal                    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
      Degeneration, Chronic, Multifocal    |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                                                                          |             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
      Necrosis, Acute, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lipocyte                        |                                                                          |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                          |             
      Hyperplasia, Cystic, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                                                          |             
      Congestion                           |                                                                          |             
      Edema, Acute, Diffuse                |                                                                          |             
      Foreign Body, Multifocal             |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 UG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic, Diffuse        |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |                                                                          |             
      Vein, Dilatation, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    0 UG/KG                                | 6| 6| 6| 6| 6|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
      Parasite Metazoan                    |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus, Multiple           |                                                                          |     40     |
      Clear Cell Focus                     |                                                                          |      9     |
      Congestion                           |                                                                          |      1  4.0|
      Degeneration, Cystic, Focal          |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      8  2.0|
      Necrosis, Acute                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |     38  2.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |     23  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  50        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |     17  2.1|
      Acinus, Focal Cellular Change        |                                                                          |      6     |
      Acinus, Hyperplasia, Focal           |                                                                          |      6  2.3|
      Duct, Ectasia, Multifocal            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Acanthosis, Focal                    |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    0 UG/KG                                | 6| 6| 6| 6| 6|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Degeneration, Chronic, Multifocal    |                                                                          |     47  2.4|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Degeneration, Fatty                  |                                                                          |      6  2.2|
      Hyperplasia                          |                                                                          |     18  2.1|
      Hypertrophy                          |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  50        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      6  2.2|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      C-Cell, Hyperplasia                  |                                                                          |     24  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  50        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |     44  2.4|
      Duct, Ectasia                        |                                                                          |      8  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  50        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |     15  2.2|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    0 UG/KG                                | 6| 6| 6| 6| 6|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Germinal Epithelium, Atrophy         |                                                                          |     43  3.7|
      Interstitial Cell, Hyperplasia       |                                                                          |     22  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  49        |
      Necrosis, Acute, Multifocal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Depletion Lymphoid                   |                                                                          |      3  2.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lipocyte                        |                                                                          |      1  3.0|
      Red Pulp, Fibrosis                   |                                                                          |      2  2.5|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  39        |
      Hyperplasia, Cystic, Multifocal      |                                                                          |     37  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active, Diffuse         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Compression                          |                                                                          |      1  4.0|
      Ventricle, Hydrocephalus             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      2  3.0|
      Edema, Acute, Diffuse                |                                                                          |      3  2.7|
      Foreign Body, Multifocal             |                                                                          |     11  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1|                                                           |      A     |
    0 UG/KG                                | 6| 6| 6| 6| 6|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Focal                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.3|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |     21  2.6|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Lens, Cataract                       |                                                                          |      3  4.0|
      Retina, Atrophy, Diffuse             |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Nephropathy, Chronic, Diffuse        |                                                                          |     48  2.6|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Cytoplasmic Alteration, Focal    |                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Focal               |                                                                          |      1  2.0|
      Vein, Dilatation, Focal              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Calculus Micro Observation Only      |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|             
                                           | 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  A           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  A           +              +  +  +     +  +        +     +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  A           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Basophilic Focus, Multiple           |    X     X              X              X           X  X                  |             
      Congestion                           |                                                                4         |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |       2                                                                  |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Acute                      |             3                                                            |             
      Bile Duct, Hyperplasia, Multifocal   |    2  3     2           2              2     2                           |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                    2                 3   |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +                 +  +        +         |             
      Inflammation, Chronic Active         |                         3                             3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Acinus, Atrophy                      |                         2                    2     2  3                  |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Acanthosis                           |                                                       3                  |             
      Inflammation, Chronic Active         |                                                       3                  |             
      Ulcer                                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
      Epithelium, Hyperplasia              |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Degeneration, Chronic, Multifocal    |    3  3  3  2           2              2  2  2     2  3        3     2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|             
                                           | 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Degeneration, Fatty                  |    2                                                                     |             
      Hyperplasia                          |          2                             2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +           +              +  +  +     +  +        +     M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +        +  +  +        +  +  +  +  +  +        +  +  +   |             
      Pars Distalis, Cyst                  |                                                 X                        |             
      Pars Distalis, Hyperplasia           |                                        2           2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +        +        +     +  +  +     +  +        +     +   |             
      C-Cell, Hyperplasia                  |    3                                   2     2                       2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +     +     +              +     +     +  +        +     +   |             
      Hyperplasia                          |                                                                      3   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |    2  2                 2              2                                 |             
      Duct, Ectasia                        |                                                                      4   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                                         4|             
      Interstitial Cell, Hyperplasia       |       2        2                                               2     2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +           +              +  +  +  +  +  +        +     +   |             
      Inguinal, Sinus, Ectasia             |                                                                          |             
      Lumbar, Sinus, Ectasia               |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|             
                                           | 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Sinus, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +           +              +  +  +  +  +  +        +     +   |             
      Infiltration Cellular, Plasma Cell   |                                                 3                    3   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +        +  +           +  +  +  +     +  +  +     +     +   |             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |          3  3                                                            |             
      Red Pulp, Fibrosis                   |                      2              2                                    |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +           +              M  +  +     M  M        +     M   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  +  +           +              +  +  +     +  +        M  +  +  +|             
      Hyperplasia, Cystic, Multifocal      |    2     3              3              3  1  3     3  3              2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +           +           +  +  +  +     +  +     +  +     +   |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +           +              +  +  +     +  +        +     +   |             
      Compression                          |    X                                                                     |             
      Ventricle, Hydrocephalus             |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +           +        +  +  +  +  +     +  +        +     +   |             
      Foreign Body, Multifocal             |                                        2           3           3         |             
      Pigmentation                         |                                        2                                 |             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                3         |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |          2                       3  3        2                           |             
      Perivascular, Edema, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +           +              +  +  +     +  +        +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Lens, Cataract                       |                      3                                                   |             
      Retina, Atrophy, Diffuse             |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 6| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 1| 3| 8| 2| 3| 3| 7| 3| 5| 3|             
                                           | 9| 6| 9| 4| 0| 9| 9| 9| 7| 9| 0| 0| 0| 6| 8| 6| 0| 7| 2| 0| 0| 8| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +           +              +  +  +     +  +        +     +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                      X   |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic, Diffuse        | 3  3  4  2  1  2  2  3  2  2  2  3  2  4  2  2  4  1  4  4  2  2  2  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |       1                                                                  |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  A           +              +  +  +     +  +        +     +   |             
      Ectasia                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|             
                                           | 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +           +  +     +     +     +  +  +  A     +  +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +           +  +     +     +     +  +  +  +     +  +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +           +  +     +     +     +  +  +  A     +  +        +      |             
      Parasite Metazoan                    |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +           +  +     +     +     +  +  +  +     +  +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +           +  +     +     +     +  +  +  +     +  +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +           +  +     +     +     +  +  +  +     +  +        +      |             
                                            __________________________________________________________________________|             
   Liver                                   |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Basophilic Focus, Multiple           |       X           X  X                 X     X        X           X      |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                         2|             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |                                        X                                 |             
      Necrosis, Acute                      |       3                                   3  3                           |             
      Bile Duct, Hyperplasia, Multifocal   |       2           2  2           3     3     3  3        3        2     3|             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                   2                    2                 3               |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +              +                                       |             
      Inflammation, Chronic Active         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Acinus, Atrophy                      |                      4                    2  2                          2|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                            4                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +           +  +     +     +     +  +  +  +     +  +        +      |             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                            3                                             |             
      Ulcer                                |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +           +  +     +     +     +  +  +  +     +  +        +      |             
      Inflammation, Acute                  |                                                       2                  |             
                                            __________________________________________________________________________|             
   Tongue                                  | +        +                                                               |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Degeneration, Chronic, Multifocal    |       3           3  2     3     3     3  3  3  3     3  2        2     3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|             
                                           | 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +           +  +     +     +     +  +  +  +     +  +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +           +  +     +     +     +  +  +  +     +  +              +|             
      Degeneration, Fatty                  |                   2                                                      |             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +           +  +     +     +     +  +  +  +     +  +              +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +           +  +     +     +     +  +  M  A     +  +        M     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +  +     +     +  +  +  +     +  +        +     +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                   2        2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +        +  +     +     +     +  +  +  A     +  +     +  +     +|             
      C-Cell, Hyperplasia                  |                                              2                          2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                   2  2                 2     2  2     2  2               |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Inflammation, Acute                  |                                                 3                        |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                 +                        |             
      Dilatation                           |                                                 3                        |             
      Inflammation, Acute                  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia       |       3                 2  2  2  2     2        2              2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +           +  +     +     A     +  +  +  +     +  +        +     +|             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Inguinal, Sinus, Ectasia             | 4                                                                        |             
      Lumbar, Sinus, Ectasia               | 3                                                                        |             
      Mediastinal, Congestion              |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|             
                                           | 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Sinus, Ectasia           |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Infiltration Cellular, Plasma Cell   | 2                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
      Angiectasis                          |                                        2                                 |             
      Depletion Lymphoid                   |                                           2     3                 2      |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +           +  M     +     +     M  M  +  +     +  +        M     +|             
      Hyperplasia, Cystic, Multifocal      |       3                    3     2           2  2     3  2              2|             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +     +  +  +  +     +  +  +  +  +  +     +  +        +     +|             
      Hyperkeratosis                       |                                     4                                    |             
      Subcutaneous Tissue, Fibrosis        |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +           +  +     +     +     +  +  +  A     +  +        +     +|             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +           +  +     +  +  +     +  +  +  +     +  +        +     +|             
      Foreign Body, Multifocal             |       2                                   2  2  2                 3      |             
      Pigmentation                         |                                                 3                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |       2                                                                  |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |    3                                                                     |             
      Perivascular, Edema, Acute           |       2                                   3                       2      |             
                                            __________________________________________________________________________|             
   Nose                                    |       +           +  +     +     +     +  +  +  +     +  +        A     +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +           +  +     +     +     +  +  +  +     +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 4| 7| 6| 2| 7| 6| 7| 4| 6| 7| 7| 4| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 2| 5| 3| 7| 3| 1| 3| 3| 6| 1| 2| 3| 0| 8| 3| 3| 8| 3| 0|             
                                           | 1| 1| 7| 1| 1| 1| 8| 6| 2| 5| 2| 8| 2| 3| 2| 7| 4| 2| 9| 1| 2| 2| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    21 UG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +           +  +     +     +     +  M  +  +     M  M        M     +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Hydronephrosis                       |                                                 3                        |             
      Nephropathy, Chronic, Diffuse        | 2  3  2  3  3  2  2  2  3  4  4  2  3  2  2  2  3  3  2  2  2  3  1  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |    2                                                                     |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                           +                              |             
      Calculus Micro Observation Only      |                                           X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +           +  +     +     +     +  A  +  +     M  +        +     +|             
      Ectasia                              |                                                 4                        |             
      Inflammation, Acute                  |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +                                             |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +                                             |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +                                             |             
                                            __________________________________________________________________________|             
   Liver                                   |                            +                                             |             
      Basophilic Focus, Multiple           |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Acute                      |                            3                                             |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                            +                                             |             
      Acinus, Atrophy                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +                                             |             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +                                             |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +                                             |             
      Degeneration, Chronic, Multifocal    |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                            +                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                            +                                             |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                            +                                             |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            +                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                            M                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                            +                                             |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                            +                                             |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                            +                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                            +                                             |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +                                             |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                            +                                             |             
      Germinal Epithelium, Atrophy         |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +                                             |             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             
      Inguinal, Sinus, Ectasia             |                                                                          |             
      Lumbar, Sinus, Ectasia               |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Sinus, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                            +                                             |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                            +                                             |             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            +                                             |             
      Hyperplasia, Cystic, Multifocal      |                            2                                             |             
                                            __________________________________________________________________________|             
   Skin                                    |                            +                                             |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                            +                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +                                             |             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                            +                                             |             
      Foreign Body, Multifocal             |                            3                                             |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Perivascular, Edema, Acute           |                            3                                             |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    21 UG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                            +                                             |             
      Cyst, Multiple                       |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic, Diffuse        |                            1                                             |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            +                                             |             
      Ectasia                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    21 UG/KG                               | 2| 2| 2| 2| 2|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  23        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  26        |
      Basophilic Focus, Multiple           |                                                                          |     13     |
      Congestion                           |                                                                          |      1  4.0|
      Degeneration, Cystic, Focal          |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Acute                      |                                                                          |      5  3.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |     16  2.4|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      5  2.4|
      Periportal, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  26        |
      Acinus, Atrophy                      |                                                                          |      8  2.4|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  25        |
      Acanthosis                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  25        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   3        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    21 UG/KG                               | 2| 2| 2| 2| 2|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  26        |
      Degeneration, Chronic, Multifocal    |                                                                          |     26  2.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  25        |
      Degeneration, Fatty                  |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  25        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  33        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  29        |
      C-Cell, Hyperplasia                  |                                                                          |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  28        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |     11  2.0|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  26        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Germinal Epithelium, Atrophy         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    21 UG/KG                               | 2| 2| 2| 2| 2|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |                                                                          |     13  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  25        |
      Femoral, Hyperplasia, Diffuse,       |                                                                          |            |
          Neutrophil                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  28        |
      Inguinal, Sinus, Ectasia             |                                                                          |      1  4.0|
      Lumbar, Sinus, Ectasia               |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mesenteric, Sinus, Ectasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  28        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  29        |
      Angiectasis                          |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      5  2.6|
      Red Pulp, Fibrosis                   |                                                                          |      2  2.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  22        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  22        |
      Hyperplasia, Cystic, Multifocal      |                                                                          |     18  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  32        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  25        |
      Compression                          |                                                                          |      1     |
      Ventricle, Hydrocephalus             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  30        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3|                                                           |      A     |
    21 UG/KG                               | 2| 2| 2| 2| 2|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body, Multifocal             |                                                                          |      9  2.4|
      Pigmentation                         |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                                                                          |      2  2.5|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      5  2.6|
      Perivascular, Edema, Acute           |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  26        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  3.0|
      Retina, Atrophy, Diffuse             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  51        |
      Cyst, Multiple                       |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Nephropathy, Chronic, Diffuse        |                                                                          |     51  2.4|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Multifocal          |                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Karyomegaly, Multifocal          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Calculus Micro Observation Only      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  23        |
      Ectasia                              |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|             
                                           | 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       A     +  +  A              +  +  +              +  +        +  +   |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     +  +  A              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +  +  A              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |       +     +  +  +              +  +  +        +     +  +        +  +   |             
      Basophilic Focus, Multiple           |             X                    X                       X           X   |             
      Cytoplasmic Alteration, Focal        |                   3                                                      |             
      Degeneration, Cystic, Focal          |                                                          2               |             
      Necrosis, Acute                      |       2                                                                  |             
      Bile Duct, Hyperplasia, Multifocal   |       2     2  3                 2  3           3                 3      |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |       2                                                                  |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +        +      |             
      Inflammation, Chronic Active         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +  +  A              +  +  +              +  +        +  +   |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia, Focal           |       2                                                              3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +     +  +  +              +  +  +              +  +        +  +   |             
      Inflammation, Chronic Active         |             1                                                        3   |             
      Ulcer                                |             2                                                        3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +  +  +              +  +  +              +  +        +  +   |             
      Degeneration, Chronic, Multifocal    |       3     2  3  3              2  3  3              3  2           3   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +           +     +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | M     +     +  +  +                 +  +              +  +        +  +   |             
      Cytoplasmic Alteration               |                                     2                                    |             
      Degeneration, Fatty                  |                                                                      2   |             
      Hyperplasia                          |                                                          1               |             
      Hypertrophy                          |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|             
                                           | 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Atrophy, Diffuse          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +           +     +  +              +  +               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +  A        +     +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     +  +  M              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +              +  M  +              +  +        +  +   |             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +  +  A           +  +  +  +              +  +        +  +   |             
      C-Cell, Hyperplasia                  |             2                    2     2                 2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +  +  +              +  +  +              +  +        +  +   |             
      Atrophy, Diffuse                     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +  +  +              +  +  +              +  +        +  +   |             
      Hyperplasia                          |                                                          3               |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                2                       2              3           3  2   |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +  +  +              +  +  +              +  +        +  +   |             
      Atrophy, Diffuse                     |                                                                   3      |             
      Epithelium, Hyperplasia, Multifocal  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 4  4  4  4     4  3  4  4  4  4  3     3  4        4  2  3  3  3  4  3  4|             
      Interstitial Cell, Hyperplasia       |       2     2                    2  2                 2  2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +  +              +  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +     +  +  +              M  +  +              +  +        +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +  +  +  +  +        +  +  +              +  +        +  +   |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     M  +  M              +  M  +              +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +     +  +  +              M  +  +              +  +  +     +  +   |             
      Hyperplasia, Cystic, Multifocal      |       2     3  2  2                    1              3  3        2  3   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +  +  +              +  +  +     +        +  +        +  +   |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|             
                                           | 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +  +  +              +  +  +              +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +  +  +              +  +  +              +  +        +  +   |             
      Compression                          |                                                                   X      |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +           +  +  +  +              +  +        +  +   |             
      Congestion                           |                                     3                                    |             
      Foreign Body, Multifocal             |       2        3                                                         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +  +  +              +  +  +              +  +        +      |             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +  +  +              +  +  +              +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                            +                     |             
      Lens, Cataract                       |                                                    3                     |             
      Retina, Atrophy, Diffuse             |                                                    4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +     +  +  +              +  +  M              +  +        M  +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy, Chronic, Diffuse        | 3  3  3  3  2  2  1  4  3  3  3  2  1  2  4  4  3  4  2  2  2  4  1  4  3|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    | 2                             3                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration,          |                                                                          |             
          Multifocal                       |                                                          2               |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  1  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               | 2     3  2                                                     2  2     2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |    2                                                                     |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| 2| 5| 4| 8| 3| 3| 3| 3| 1| 0| 3| 3| 1| 1| 3|             
                                           | 9| 9| 4| 9| 9| 6| 0| 9| 9| 9| 9| 4| 6| 1| 0| 0| 0| 0| 6| 7| 0| 0| 2| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |       2                                2                                 |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |    2                                         2                       2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +  +  A              +  +  +              +  +        +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|             
                                           | 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        A        +  +           +        +  +  +  +     +           +  +|             
      Inflammation, Chronic Active, Diffuse|                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +        +  +           +        +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +        +  +           +        +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +        +  +           +        +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        A        +  +           +        +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        A        +  +           +        +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Basophilic Focus, Multiple           | X        X                       X              X                        |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |          3                             2     3  2  3     2           2   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                 +                                 |             
      Inflammation, Chronic Active         |                   4  4                 4                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Acinus, Atrophy                      |                                              4                           |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                 +                       +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Degeneration, Chronic, Multifocal    | 3        3        3  2           3     2     2     3     3           2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +        +  +        +  +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +        +  +        +  +     +  +  +  +  +     +           +  +|             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Fatty                  |                   2  2                                                   |             
      Hyperplasia                          |                                                                      2   |             
      Hypertrophy                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|             
                                           | 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Atrophy, Diffuse          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +        +  +        +  +     +  +  +  +  +     +           +  +|             
      Hyperplasia                          |          3                                   2                       2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M        +        +  +           +     M  +  +  +  +     +           M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +        +  +     +     +     +  I  +  +  +     +        +  +  +|             
      Pars Distalis, Cyst                  |                                                                      X   |             
      Pars Distalis, Hyperplasia           |                                  2                 3                 2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +        +  +           +     +  +  +  +  +     +        +  +  +|             
      C-Cell, Hyperplasia                  |                      2                 2  2     2  2                    2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Atrophy, Diffuse                     |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                      3                    3     2  2                 2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Epithelium, Hyperplasia, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 3  3  4     4  4  3     4  4     4  4        4  3  3  4     4  4  4  4   |             
      Interstitial Cell, Hyperplasia       | 2        2           2     2                       2  2           2     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +        +  +           +     +  +  +  +  +     +           +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +        +  +     +     A     +  +  +  +  +     +           +  +|             
      Red Pulp, Fibrosis                   |          3                                                               |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +        +  +           +     +  +  M  +  +     +           +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        M        +  +           M     +  +  +  +  +     +           +  +|             
      Hyperplasia, Cystic, Multifocal      | 2                    2                 3  3  4  3  3                 2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +     +     +     I  +  +  +  +  +  +           +  +|             
      Hyperkeratosis                       |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|             
                                           | 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +        +  +           +     +  +  +  +  +     +           +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Congestion                           |                                                          2               |             
      Foreign Body, Multifocal             |          3                                               2               |             
      Alveolar Epithelium, Hyperplasia     |                                              3                          3|             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                          2               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                  2              3                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +        +  +           +     +  +  +  +  +     +           +  +|             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +        +  +           +     +  +  +  +  +     +           +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                            +                        |             
      Lens, Cataract                       |    2                                                                     |             
      Retina, Atrophy, Diffuse             |    4                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +        +        +  +           +     M  +  M  +  +     +           M  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                       2                  |             
      Nephropathy, Chronic, Diffuse        | 2  3  2  4  2  3  2  2  4  2  3  2  3  2  1  2  2  3  4  1  4  3  3  2  1|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         | 1  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |          2     2     2        2                       2                  |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |             2              2                       2        2            |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          | 1  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 2| 6| 7| 6| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 6| 3| 3| 0| 3| 3| 4| 7| 3| 3| 3| 6| 3| 4| 9| 9| 1| 7| 3| 9| 3| 3| 3| 1| 8|             
                                           | 1| 1| 1| 9| 1| 1| 4| 2| 1| 2| 2| 9| 2| 0| 7| 1| 6| 4| 2| 0| 2| 2| 2| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |                            2                       2                     |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |    3     2                                                  2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +        +  +           +     +  +  +  +  +     +           +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                         A                                                |             
      Inflammation, Chronic Active, Diffuse|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                         A                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                         A                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                         +                                                |             
                                            __________________________________________________________________________|             
   Liver                                   |                         +                                                |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |                         2                                                |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                         +                                                |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 |                         +                                                |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                         +                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                         +                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                         +                                                |             
      Degeneration, Chronic, Multifocal    |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                         +                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                         +                                                |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Atrophy, Diffuse          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                         +                                                |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                         +                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                         +                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                         +                                                |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                         +                                                |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                         +                                                |             
      Atrophy, Diffuse                     |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +                                                |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                         +                                                |             
      Atrophy, Diffuse                     |                                                                          |             
      Epithelium, Hyperplasia, Multifocal  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |                         +                                                |             
      Germinal Epithelium, Atrophy         |                         3                                                |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                         +                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                         +                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  |                         +                                                |             
      Red Pulp, Fibrosis                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                         +                                                |             
      Hyperplasia, Cystic, Multifocal      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                         +                                                |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                         +                                                |             
      Compression                          |                                                                          |             
      Ventricle, Hydrocephalus             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                         +                                                |             
      Congestion                           |                                                                          |             
      Foreign Body, Multifocal             |                         2                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                         +                                                |             
      Nasolacrimal Duct, Hyperplasia       |                         3                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy, Diffuse             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         M                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                         +                                                |             
      Fibrosis, Focal                      |                                                                          |             
      Nephropathy, Chronic, Diffuse        |                         1                                                |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration, Focal    |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Cytoplasmic Alteration,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Degeneration, Multifocal         |                         2                                                |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Focal               |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Hyperplasia, Multifocal          |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Karyomegaly, Multifocal          |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 2| 8| 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    70 UG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Focal             |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |      A     |
    70 UG/KG                               | 8| 8| 8| 8| 8|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  20        |
      Inflammation, Chronic Active, Diffuse|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  26        |
      Basophilic Focus, Multiple           |                                                                          |      8     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  3.0|
      Degeneration, Cystic, Focal          |                                                                          |      1  2.0|
      Necrosis, Acute                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |     14  2.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      2  2.0|
      Periportal, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Inflammation, Chronic Active         |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  24        |
      Acinus, Atrophy                      |                                                                          |      1  4.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  25        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  25        |
      Degeneration, Chronic, Multifocal    |                                                                          |     22  2.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  28        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |      A     |
    70 UG/KG                               | 8| 8| 8| 8| 8|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  25        |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      3  2.0|
      Hyperplasia                          |                                                                          |      2  1.5|
      Hypertrophy                          |                                                                          |      1  2.0|
      Bilateral, Atrophy, Diffuse          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  26        |
      Hyperplasia                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  27        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  26        |
      C-Cell, Hyperplasia                  |                                                                          |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  25        |
      Atrophy, Diffuse                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |  25        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |     11  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  25        |
      Atrophy, Diffuse                     |                                                                          |      1  3.0|
      Epithelium, Hyperplasia, Multifocal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  48        |
      Germinal Epithelium, Atrophy         |                                                                          |     40  3.6|
      Interstitial Cell, Hyperplasia       |                                                                          |     14  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  27        |
      Red Pulp, Fibrosis                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 108                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |      A     |
    70 UG/KG                               | 8| 8| 8| 8| 8|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  20        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  23        |
      Hyperplasia, Cystic, Multifocal      |                                                                          |     18  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  30        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  25        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  25        |
      Compression                          |                                                                          |      1     |
      Ventricle, Hydrocephalus             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  27        |
      Congestion                           |                                                                          |      2  2.5|
      Foreign Body, Multifocal             |                                                                          |      5  2.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  3.0|
      Interstitium, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  24        |
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  25        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Lens, Cataract                       |                                                                          |      2  2.5|
      Retina, Atrophy, Diffuse             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  19        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 109                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2|                                                           |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7|                                                           |            |
                                           | 7| 7| 7| 7| 7|                                                           |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4|                                                           |      A     |
    70 UG/KG                               | 8| 8| 8| 8| 8|                                                           |      L     |
                                           | 1| 2| 3| 4| 5|                                                           |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Nephropathy, Chronic, Diffuse        |                                                                          |     51  2.6|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Cytoplasmic Alteration, Focal    |                                                                          |      2  2.5|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Cytoplasmic Alteration,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Degeneration, Multifocal         |                                                                          |     50  1.9|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Focal               |                                                                          |     11  2.1|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Hyperplasia, Multifocal          |                                                                          |      5  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Karyomegaly, Multifocal          |                                                                          |     51  1.9|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Proliferation, Focal             |                                                                          |      4  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  24        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 110                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|             
                             DAY ON TEST   | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|             
                                           | 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    210 UG/                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Acute, Focal               |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Basophilic Focus, Multiple           | X  X              X     X  X  X        X  X  X  X  X  X  X     X  X      |             
      Clear Cell Focus                     | X  X                          X                    X                     |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                    2           2         |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |                               X                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                       2                  |             
      Necrosis, Acute                      |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   | 2  2  2  2  4     2  2     3  3  3                 3  2        3  2     3|             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic, Diffuse             |    2  3     2           2     2     2  2        3  2  2  3               |             
      Periportal, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                             4            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +                    +  +     +                       +  +|             
      Inflammation, Chronic Active         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic, Diffuse       |                               3                                          |             
      Acinus, Atrophy                      |       2           3        2  4                 2        2           3   |             
      Acinus, Focal Cellular Change        |                            X                                            X|             
      Acinus, Hyperplasia, Focal           |                                                 2           2            |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                4  3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Acinus, Atrophy, Multifocal          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05036-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            OCHRATOXIN A                                       Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 12:01:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 4| 5| 4| 7| 6| 6| 7| 7| 6| 4| 5| 6| 6| 5| 7| 7| 5| 7| 7| 7| 3| 4|             
                             DAY ON TEST   | 2| 2| 1| 2| 1| 1| 2| 3| 4| 2| 2| 9| 0| 4| 4| 8| 8| 2| 3| 4| 3| 3| 3| 9| 3|             
                                           | 9| 9| 3| 5| 3| 5| 9| 8| 7| 9| 9| 0| 0| 0| 9| 4| 9| 9| 0| 0| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    210 UG/                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    KG                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                          |             
      Acanthosis                           |    3                                         2  3           4            |             
      Acanthosis, Multifocal               |                                                                      2   |             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Erosion                              |                                                 1                        |             
      Inflammation, Chronic Active         |                   3                    3        3           2            |             
      Ulcer                                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal              |                                  2                                       |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithe