National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3082

TR 358 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/05/94   
EXP: 05036                       OCHRATOXIN A                  TIME: 02:39:36   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56586    
CONT: N01-CP-95653                                             CAS: 303-47-9    
PATHOLOGIST: R. PERSING                      S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/05/94  
EXP: 05036                       OCHRATOXIN A                  TIME: 02:39:36  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56586   
CONT: N01-CP-95653                                             CAS: 303-47-9   
PATHOLOGIST: R. PERSING                      S. EUSTIS                         

                                   OCHRATOXIN A


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 UG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 7      CENSORED DEATHS 34   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      495   516   526   540   691   704   712                                   |
 |  CENSORED DEATHS                                                               |
 |      10    10    277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   277   277   377   458   458                 |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |      458   458   458   486                                                     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 21 UG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 19     CENSORED DEATHS 35   TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      280   409   418   487   555   556   624   627   628   633                 |
 |      674   675   676   681   702   716   717   722   726                       |
 |  CENSORED DEATHS                                                               |
 |      262   277   277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   277   287   417   428   458                 |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |      458   458   458   488   678                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 70 UG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 23     CENSORED DEATHS 31   TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      382   459   507   516   524   540   544   546   554   561                 |
 |      572   589   669   674   681   691   706   709   712   712                 |
 |      716   717   720                                                           |
 |  CENSORED DEATHS                                                               |
 |      277   277   277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   290   297   458   458   458                 |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |      458                                                                       |
 |                                                                                |
 ==================================================================================

                                   OCHRATOXIN A


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 210 UG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 26     CENSORED DEATHS 31   TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      390   400   408   415   425   439   506   513   513   540                 |
 |      540   540   540   544   561   569   589   638   647   647                 |
 |      649   667   684   690   702   723                                         |
 |  CENSORED DEATHS                                                               |
 |      277   277   277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   458   458   458   458   458                 |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |      647                                                                       |
 |                                                                                |
 ==================================================================================

                                   OCHRATOXIN A


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 UG/KG    |   100.0 100.0 100.0 100.0 100.0 100.0  91.3  91.3  91.3  84.8      |
 |           |                                                                    |
 |           |                                                                    |
 |21 UG/KG   |   100.0 100.0 100.0  98.4  95.2  95.2  93.1  88.6  79.8  59.4      |
 |           |                                                                    |
 |           |                                                                    |
 |70 UG/KG   |   100.0 100.0 100.0 100.0  98.4  96.4  86.1  75.9  75.9  53.3      |
 |           |                                                                    |
 |           |                                                                    |
 |210 UG/ KG |   100.0 100.0 100.0 100.0  92.3  90.8  74.3  68.1  59.8  49.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 UG/KG      21 UG/KG     70 UG/KG     210 UG/ K|
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       84.8%        59.4%        53.3%        49.1%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.001      P=0.011      P=0.002      P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       597.7        605.6        608.7        556.9    |
 |NATURAL DEATHS (C)      |       (37.4)       (28.8)       (20.7)       (20.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       556.5        544.8        551.4        536.5    |
 |(STANDARD ERROR)        |       (22.4)       (20.3)       (19.9)       (18.8)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   OCHRATOXIN A


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 UG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 17     CENSORED DEATHS 31   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      216   466   495   497   525   568   583   598   648   654                 |
 |      654   660   673   675   689   695   721                                   |
 |  CENSORED DEATHS                                                               |
 |      277   277   277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   425   454   454   454   454                 |
 |      454   454   454   454   454   454   454   454   454   454                 |
 |      454                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 21 UG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 25     CENSORED DEATHS 32   TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      201   452   452   525   538   577   585   622   624   626                 |
 |      632   637   638   645   646   658   658   665   665   674                 |
 |      704   716   716   718   726                                               |
 |  CENSORED DEATHS                                                               |
 |      5     277   277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   277   415   436   454   454                 |
 |      454   454   454   454   454   454   454   454   454   454                 |
 |      454   454                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 70 UG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 15     CENSORED DEATHS 30   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      319   370   466   506   506   564   589   622   637   659                 |
 |      665   667   669   695   697                                               |
 |  CENSORED DEATHS                                                               |
 |      277   277   277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   454   454   454   454   454                 |
 |      454   454   454   454   454   454   454   454   454   454                 |
 |                                                                                |
 ==================================================================================

                                   OCHRATOXIN A


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 210 UG/ KG                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 80     UNCENSORED DEATHS 15     CENSORED DEATHS 30   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      305   400   415   436   520   520   560   568   626   630                 |
 |      645   659   699   713   721                                               |
 |  CENSORED DEATHS                                                               |
 |      277   277   277   277   277   277   277   277   277   277                 |
 |      277   277   277   277   277   454   454   454   454   454                 |
 |      454   454   454   454   454   454   454   454   454   454                 |
 |                                                                                |
 ==================================================================================

                                   OCHRATOXIN A


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 728 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 UG/KG    |   100.0 100.0  98.8  98.8  98.8  96.7  90.5  84.3  76.1  65.8      |
 |           |                                                                    |
 |           |                                                                    |
 |21 UG/KG   |   100.0 100.0  98.7  98.7  98.7  95.5  91.3  87.0  61.5  48.8      |
 |           |                                                                    |
 |           |                                                                    |
 |70 UG/KG   |   100.0 100.0 100.0  98.5  96.9  94.9  90.9  86.8  78.8  70.7      |
 |           |                                                                    |
 |           |                                                                    |
 |210 UG/ KG |   100.0 100.0 100.0  98.5  95.4  93.8  89.8  85.7  77.5  71.4      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 UG/KG      21 UG/KG     70 UG/KG     210 UG/ K|
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       65.8%        48.8%        70.7%        71.4%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.269N     P=0.140      P=0.788N     P=0.825N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       589.2        612.0        575.4        561.1    |
 |NATURAL DEATHS (C)      |       (30.1)       (22.6)       (30.6)       (32.7)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       558.8        542.6        563.5        560.8    |
 |(STANDARD ERROR)        |       (20.1)       (20.7)       (20.1)       (20.2)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            OCHRATOXIN A
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 UG/KG          = 1
                                                        21 UG/KG         = 2
                                                        70 UG/KG         = 3
                                                        210 UG/ KG       = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                           2                34               1
      |                                             2                34 422      3    1 31
      |                                                                  424         2  31  1
      |                                                                    4 4       2   3 31 1 2                    1
P  90 +                                                                      4          4  3  3                      1 1
E     |                                                                                 44      2          2           11
R     |                                                                                  4    3 3                       1   1
C     |                                                                                         33         22
E  80 +                                                                                          33         2      2
N     |                                                                                           3   3
T     |                                                                                       4  4    3           33
      |                                                                                          44                22
S  70 +                                                                                           4   4             23 2
U     |                                                                                               4      4       3 2 2
R     |                                                                                                      44        3322
V     |
I  60 +                                                                                                       4   4     332 2
V     |                                                                                                           4 4
A     |                                                                                                             44
L     |                                                                                                              4 4 3  3
   50 +                                                                                                                4  4 4
      |
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 18 obs hidden.

                                                            OCHRATOXIN A
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 UG/KG          = 1
                                                        21 UG/KG         = 2
                                                        70 UG/KG         = 3
                                                        210 UG/ KG       = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                               2 1             4  3                      1
      |                                 2               4  3      3     4 4     2 1   1
      |                                                                   4  4  2 3     3  2
      |                                                                               1    1 2     2
P  90 +                                                                                 3  1    43122 3
E     |                                                                                         4 1 1 31  2
R     |                                                                                           4    1  223 1
C     |                                                                                                    43 11 3
E  80 +                                                                                                    22 4  33
N     |                                                                                                     22 1 1    4
T     |                                                                                                      22  131  3 4
      |                                                                                                            1 1  444
S  70 +                                                                                                       22     11   3
U     |                                                                                                               1  1
R     |                                                                                                        2 2       11
V     |                                                                                                          2 2
I  60 +                                                                                                            2   2
V     |                                                                                                                2 2
A     |
L     |
   50 +                                                                                                                  22
      |
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 26 obs hidden.

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