National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1313

TR 364 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            RHODAMINE 6G


NTP Experiment-Test: 05048-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 01:34:21




       Facility:  Southern Research Institute

       Chemical CAS #:  989-38-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               8            7            6                                                  
    Moribund                                           3            8            7                                                  
    Natural Death                                                                1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           35           35                                                  
    Terminal Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small                                    (49)         (45)         (48)                                                
      Duodenum, Jejunum, Autolysis                     1 (2%)                                                                       
      Ileum, Amyloid Deposition                        1 (2%)                                                                       
      Ileum, Peyer's Patch, Foreign Body                            1 (2%)                                                          
      Ileum, Peyer's Patch, Hyperplasia, Lymphoid      1 (2%)       1 (2%)                                                          
      Ileum, Peyer's Patch, Inflammation,                                                                                           
          Suppurative                                               1 (2%)                                                          
      Jejunum, Peyer's Patch, Hyperplasia, Lymphoid    1 (2%)                    1 (2%)                                             
      Wall, Inflammation, Suppurative                  2 (4%)                                                                       
   Liver                                              (50)         (50)         (49)                                                
      Angiectasis                                                   2 (4%)                                                          
      Hematopoietic Cell Proliferation                 9 (18%)      4 (8%)       6 (12%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                3 (6%)       5 (10%)      4 (8%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Suppurative                        2 (4%)       2 (4%)       1 (2%)                                             
      Mitotic Alteration                                            1 (2%)                                                          
      Necrosis, Focal                                  2 (4%)                    1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)                                                                       
      Nuclear Alteration                                            1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Hepatocyte, Atrophy, Focal                                    1 (2%)                                                          
   Mesentery                                          (11)         (3)          (8)                                                 
      Inflammation, Suppurative                        4 (36%)      1 (33%)      6 (75%)                                            
      Fat, Inflammation, Chronic                       1 (9%)                                                                       
      Fat, Necrosis, Focal                             3 (27%)      2 (67%)                                                         
   Pancreas                                           (49)         (48)         (47)                                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       2 (4%)                                                          
      Acinus, Atrophy, Focal                           1 (2%)                    1 (2%)                                             
      Acinus, Atrophy, Multifocal                                   1 (2%)       1 (2%)                                             
      Acinus, Hyperplasia                                           1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Cyst                                       2 (4%)       1 (2%)                                                          
      Duct, Inflammation, Suppurative                  1 (2%)                                                                       
   Stomach                                            (49)         (48)         (47)                                                
      Forestomach, Diverticulum                        1 (2%)                                                                       
      Forestomach, Foreign Body                                                  1 (2%)                                             
      Forestomach, Hyperkeratosis, Focal               1 (2%)                                                                       
      Forestomach, Inflammation, Granulomatous                                   1 (2%)                                             
      Forestomach, Inflammation, Suppurative           2 (4%)       2 (4%)                                                          
      Forestomach, Ulcer                                            1 (2%)       1 (2%)                                             
      Glandular, Hyperplasia, Focal                                              1 (2%)                                             
   Tooth                                                           (1)                                                              
      Dysplasia                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)                                                
      Inflammation, Focal, Suppurative                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (49)         (49)                                                
      Capsule, Degeneration, Fatty                     1 (2%)                                                                       
      Cortex, Degeneration, Fatty, Focal               1 (2%)       2 (4%)       2 (4%)                                             
      Cortex, Hyperplasia, Diffuse                                               1 (2%)                                             
      Medulla, Degeneration, Fatty                                  1 (2%)                                                          
      Medulla, Hyperplasia, Focal                      1 (2%)                                                                       
      Spindle Cell, Hyperplasia, Multifocal                         1 (2%)                                                          
   Pituitary Gland                                    (49)         (44)         (46)                                                
      Pars Distalis, Angiectasis                       8 (16%)      3 (7%)       6 (13%)                                            
      Pars Distalis, Cyst                              2 (4%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                5 (10%)      8 (18%)      5 (11%)                                            
   Thyroid Gland                                      (50)         (50)         (48)                                                
      Cyst                                             1 (2%)                    1 (2%)                                             
      Degeneration, Cystic                             6 (12%)      5 (10%)      7 (15%)                                            
      Hyperplasia, Cystic                              4 (8%)       1 (2%)       3 (6%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Follicular Cell, Hyperplasia, Diffuse            1 (2%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia, Focal              3 (6%)                    3 (6%)                                             
      Follicular Cell, Hyperplasia, Multifocal                      1 (2%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (45)         (48)                                                
      Cyst                                            12 (25%)     20 (44%)     16 (33%)                                            
      Inflammation, Suppurative                        9 (19%)      6 (13%)      6 (13%)                                            
   Uterus                                             (50)         (50)         (49)                                                
      Angiectasis                                                                1 (2%)                                             
      Hydrometra                                                                 1 (2%)                                             
      Hyperplasia, Cystic                             47 (94%)     48 (96%)     44 (90%)                                            
      Hyperplasia, Glandular                                                     1 (2%)                                             
      Inflammation, Suppurative                        8 (16%)      9 (18%)     11 (22%)                                            
      Wall, Thrombosis                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (48)         (49)                                                
      Myelofibrosis                                    2 (4%)       3 (6%)       2 (4%)                                             
      Myeloid Cell, Hyperplasia                        6 (13%)      3 (6%)       5 (10%)                                            
   Lymph Node                                         (50)         (50)         (49)                                                
      Iliac, Autolysis                                                           1 (2%)                                             
      Iliac, Hyperplasia, Lymphoid                                  1 (2%)                                                          
      Lumbar, Angiectasis                              1 (2%)                                                                       
      Lumbar, Hyperplasia, Lymphoid                                 1 (2%)       1 (2%)                                             
      Mandibular, Hyperplasia, Lymphoid                             1 (2%)       3 (6%)                                             
      Mediastinal, Hyperplasia, Lymphoid               2 (4%)                    1 (2%)                                             
      Mediastinal, Inflammation, Suppurative                        1 (2%)       2 (4%)                                             
      Mesenteric, Angiectasis                          4 (8%)       1 (2%)       2 (4%)                                             
      Mesenteric, Hematopoietic Cell Proliferation     1 (2%)       2 (4%)                                                          
      Mesenteric, Hyperplasia, Lymphoid                3 (6%)       3 (6%)       4 (8%)                                             
      Pancreatic, Hyperplasia, Lymphoid                                          1 (2%)                                             
      Renal, Hyperplasia, Lymphoid                     1 (2%)       1 (2%)       1 (2%)                                             
   Spleen                                             (49)         (49)         (49)                                                
      Atrophy                                                       1 (2%)                                                          
      Hematopoietic Cell Proliferation                10 (20%)      7 (14%)     12 (24%)                                            
      Hyperplasia, Lymphoid                            4 (8%)       5 (10%)      6 (12%)                                            
      Necrosis, Focal                                  1 (2%)                                                                       
      Pigmentation                                                  3 (6%)       1 (2%)                                             
   Thymus                                             (48)         (48)         (40)                                                
      Hyperplasia, Lymphoid                                         1 (2%)       1 (3%)                                             
      Mediastinum, Inflammation, Suppurative           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (47)         (49)                                                
      Hyperplasia, Lobular                                          1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
      Duct, Ectasia                                                 1 (2%)       3 (6%)                                             
   Skin                                               (50)         (50)         (49)                                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Fibrous Osteodystrophy                           1 (2%)       2 (4%)       2 (4%)                                             
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Mineralization                                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (48)         (49)                                                
      Compression                                                                1 (2%)                                             
      Corpora Amylacea                                 8 (16%)      6 (13%)     13 (27%)                                            
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Meninges, Infiltration Cellular, Lymphocyte                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Hemorrhage                                       2 (4%)                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                3 (6%)       2 (4%)       5 (10%)                                            
      Inflammation, Suppurative                        2 (4%)                    1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal                       2 (4%)       4 (8%)                                             
      Mediastinum, Inflammation, Suppurative           1 (2%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (5)                                                              
      Hyperplasia                                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        UNTREATD     0.05%        0.1%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Atrophy                                                       1 (2%)                                                          
      Casts Protein                                                              1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Glomerulosclerosis                                                         2 (4%)                                             
      Hydronephrosis                                                1 (2%)                                                          
      Infiltration Cellular, Lymphocyte               21 (42%)     29 (58%)     28 (57%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Focal, Granulomatous                                         1 (2%)                                             
      Metaplasia, Osseous                                           1 (2%)       1 (2%)                                             
      Nephropathy, Chronic                             3 (6%)       5 (10%)      3 (6%)                                             
      Glomerulus, Amyloid Deposition                                1 (2%)       1 (2%)                                             
      Interstitial Tissue, Mineralization                           2 (4%)       1 (2%)                                             
      Renal Tubule, Dilatation                                      1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (48)         (47)         (49)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            9            8                                                  
    Moribund                                           8            8            4                                                  
    Moribund Sacrifice                                 1                                                                            
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           32           38                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small                                    (46)         (46)         (45)                                                
      Ileum, Peyer's Patch, Hyperplasia, Lymphoid      2 (4%)                    1 (2%)                                             
   Liver                                              (49)         (49)         (50)                                                
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Basophilic Focus                                 2 (4%)                                                                       
      Cyst                                             3 (6%)       1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       3 (6%)       2 (4%)                                             
      Hemorrhage, Chronic                                                        1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (4%)                                                                       
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Necrosis                                         2 (4%)       4 (8%)       1 (2%)                                             
      Pigmentation, Hemosiderin                                                  2 (4%)                                             
   Mesentery                                          (2)          (5)          (5)                                                 
      Hemorrhage                                       1 (50%)                                                                      
      Fat, Necrosis, Focal                                          3 (60%)      4 (80%)                                            
   Pancreas                                           (48)         (49)         (48)                                                
      Acinus, Atrophy, Multifocal                                   1 (2%)                                                          
      Acinus, Hyperplasia                                           1 (2%)                                                          
   Salivary Glands                                    (49)         (49)         (49)                                                
      Cyst                                             1 (2%)                                                                       
   Stomach                                            (48)         (49)         (50)                                                
      Forestomach, Cyst                                             1 (2%)       1 (2%)                                             
      Forestomach, Edema                               1 (2%)                                                                       
      Forestomach, Inflammation, Suppurative                        1 (2%)                                                          
      Forestomach, Ulcer                                                         1 (2%)                                             
      Glandular, Mineralization                                                  1 (2%)                                             
   Tooth                                              (4)          (3)          (5)                                                 
      Dysplasia                                        4 (100%)     3 (100%)     2 (40%)                                            
      Inflammation, Chronic                                         1 (33%)                                                         
      Inflammation, Suppurative                        1 (25%)      2 (67%)      3 (60%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (48)         (49)                                                
      Cortex, Hyperplasia, Focal                                    1 (2%)                                                          
      Medulla, Hyperplasia, Focal                      1 (2%)                                                                       
      Medulla, Hyperplasia, Multifocal                                           1 (2%)                                             
      Spindle Cell, Hyperplasia, Focal                 4 (8%)       1 (2%)                                                          
      Spindle Cell, Hyperplasia, Multifocal            1 (2%)                                                                       
   Parathyroid Gland                                  (44)         (40)         (41)                                                
      Cyst                                                                       1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (50)                                                
      Degeneration, Cystic                            13 (26%)     12 (24%)      9 (18%)                                            
      Hyperplasia, Cystic                              3 (6%)       2 (4%)       5 (10%)                                            
      Infiltration Cellular, Lymphocyte                2 (4%)                                                                       
      C-Cell, Hyperplasia, Focal                                                 1 (2%)                                             
      Follicle, Cyst                                   2 (4%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia, Focal              3 (6%)       4 (8%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (49)         (50)                                                
      Inflammation, Diffuse, Suppurative                            1 (2%)                                                          
   Preputial Gland                                    (12)         (15)         (25)                                                
      Fibrosis                                                                   1 (4%)                                             
      Infiltration Cellular, Lymphocyte                1 (8%)                    2 (8%)                                             
      Inflammation, Chronic                            1 (8%)                    2 (8%)                                             
      Inflammation, Granulomatous                                                3 (12%)                                            
      Inflammation, Suppurative                        6 (50%)     10 (67%)      8 (32%)                                            
      Metaplasia, Osseous                                                        1 (4%)                                             
      Mineralization                                   1 (8%)                    2 (8%)                                             
      Duct, Ectasia                                    7 (58%)     12 (80%)     17 (68%)                                            
      Duct, Inflammation, Suppurative                  1 (8%)                                                                       
   Prostate                                           (47)         (48)         (50)                                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Seminal Vesicle                                    (1)          (2)          (2)                                                 
      Atrophy                                          1 (100%)                                                                     
      Inflammation, Suppurative                                     1 (50%)                                                         
   Testes                                             (49)         (47)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Mineralization                                                1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                                                    1 (2%)                                             
      Myelofibrosis                                    1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                        9 (18%)      7 (14%)      5 (10%)                                            
   Lymph Node                                         (50)         (50)         (50)                                                
      Inguinal, Hyperplasia, Lymphoid                  2 (4%)       2 (4%)       9 (18%)                                            
      Inguinal, Hyperplasia, Plasma Cell               1 (2%)                                                                       
      Inguinal, Necrosis                                            1 (2%)                                                          
      Inguinal, Pigmentation                           2 (4%)                    1 (2%)                                             
      Inguinal, Renal, Iliac, Autolysis                1 (2%)                                                                       
      Mandibular, Hyperplasia, Lymphoid                2 (4%)                    2 (4%)                                             
      Mandibular, Pigmentation                                                   1 (2%)                                             
      Mesenteric, Angiectasis                         13 (26%)      8 (16%)      3 (6%)                                             
      Mesenteric, Hematopoietic Cell Proliferation     7 (14%)      1 (2%)       1 (2%)                                             
      Mesenteric, Hyperplasia, Lymphoid                8 (16%)      2 (4%)       2 (4%)                                             
      Mesenteric, Syncytial Alteration                 1 (2%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                                          1 (2%)                                             
      Renal, Hyperplasia                               1 (2%)                                                                       
   Spleen                                             (49)         (49)         (48)                                                
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation                14 (29%)     13 (27%)      6 (13%)                                            
      Hyperplasia, Lymphoid                            3 (6%)       1 (2%)       2 (4%)                                             
      Lymphoid Follicle, Amyloid Deposition            1 (2%)                                                                       
   Thymus                                             (31)         (40)         (47)                                                
      Hyperplasia, Lymphoid                                         1 (3%)                                                          
      Necrosis                                                      1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (50)         (50)                                                
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Fibrosis, Focal                                 17 (35%)     25 (50%)     24 (48%)                                            
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic, Focal                     2 (4%)                    4 (8%)                                             
      Inflammation, Focal, Suppurative                 3 (6%)       2 (4%)       1 (2%)                                             
      Mineralization                                   1 (2%)       1 (2%)       1 (2%)                                             
      Necrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Ulcer, Focal                                     5 (10%)      4 (8%)       1 (2%)                                             
      Subcutaneous Tissue, Abscess, Chronic            1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Edema                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (2)                                                 
      Inflammation, Suppurative                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (49)                                                
      Corpora Amylacea                                 2 (4%)      12 (24%)     10 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                                    1 (2%)       1 (2%)                                             
      Embolus Tumor                                                 1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                    1 (2%)                                             
      Necrosis, Diffuse                                                          1 (2%)                                             
      Necrosis, Multifocal                                          1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Diffuse        1 (2%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          3 (6%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Multifocal     1 (2%)       1 (2%)       1 (2%)                                             
      Bronchus, Foreign Body                                                     1 (2%)                                             
      Bronchus, Inflammation, Suppurative                                        1 (2%)                                             
   Nose                                               (48)         (46)         (43)                                                
      Lumen, Foreign Body                                           1 (2%)       5 (12%)                                            
      Lumen, Inflammation, Suppurative                 1 (2%)                    5 (12%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
      Submucosa, Sinus, Inflammation,                                                                                               
          Granulomatous, Suppurative                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05048-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            RHODAMINE 6G                                       Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 01:34:21  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          UNTREATD     0.1%         0.2%                                                   
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Bacterium                                                                  2 (4%)                                             
      Degeneration, Focal                                           1 (2%)                                                          
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                                       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Lymphocyte               23 (46%)     23 (47%)     18 (36%)                                            
      Inflammation, Suppurative                                     2 (4%)       2 (4%)                                             
      Nephropathy, Chronic                            38 (76%)     34 (69%)     42 (84%)                                            
      Cortex, Cyst                                                  1 (2%)                                                          
      Cortex, Fibrosis                                                           1 (2%)                                             
      Corticomedullary Junction, Fibrosis                           1 (2%)                                                          
      Interstitial Tissue, Mineralization             37 (74%)     34 (69%)     40 (80%)                                            
      Interstitial Tissue, Pigmentation                                          1 (2%)                                             
      Medulla, Cyst                                                 1 (2%)                                                          
      Renal Tubule, Dilatation                                      1 (2%)                                                          
   Urethra                                                         (1)          (1)                                                 
      Inflammation                                                  1 (100%)                                                        
   Urinary Bladder                                    (48)         (48)         (48)                                                
      Inflammation, Proliferative                                                1 (2%)                                             
      Mucosa, Inflammation, Suppurative                             1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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                             ----------              END OF REPORT             ----------                                           
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