National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1335

TR 364 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/07/94   
EXP: 05048                       RHODAMINE 6G                  TIME: 00:11:14   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 56122    
CONT: N01-ES-28024                                             CAS: 989-38-8    
PATHOLOGIST: H. GILES                                                           
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/07/94  
EXP: 05048                       RHODAMINE 6G                  TIME: 00:11:14  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 56122   
CONT: N01-ES-28024                                             CAS: 989-38-8   
PATHOLOGIST: H. GILES                                                          

                                   RHODAMINE 6G


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      574   576   585   600   603   603   618   620   621   661                 |
 |      662   667   668   672   694   694   694   694   695   695                 |
 |      695   697   698   699   713   724   724   724                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.012%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 29     CENSORED DEATHS 0    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      522   538   559   583   619   620   620   639   643   646                 |
 |      646   647   647   654   660   662   663   668   692   692                 |
 |      694   695   695   696   708   720   722   728   729                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.025%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      367   453   468   482   576   629   643   650   653   657                 |
 |      657   664   667   680   694   695   698   698   699   708                 |
 |      715   722   727                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   RHODAMINE 6G


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  88.0  78.0  44.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.012%     |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  92.0  66.0  42.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.025%     |   100.0 100.0 100.0 100.0  98.0  92.0  92.0  90.0  76.0  54.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATD         0.012%           0.025%        |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       44.0%            42.0%            54.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.421N         P=0.809          P=0.461N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       663.2            655.4            634.9         |
 |NATURAL DEATHS (C)      |       ( 9.1)           (10.0)           (20.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       693.9            688.0            687.9         |
 |(STANDARD ERROR)        |       ( 7.1)           ( 8.0)           (11.6)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   RHODAMINE 6G


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = UNTREATD CONTROL                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      405   531   533   600   602   607   626   646   653   661                 |
 |      665   667   669   675   695   695   700   724   725   726                 |
 |      729                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.012%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      569   572   575   603   638   643   657   660   664   668                 |
 |      675   696   697   700   722   725   725   728   728   729                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.025%                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      361   405   415   531   553   575   620   623   629   631                 |
 |      635   643   660   662   694   697   727   728   729   729                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                   RHODAMINE 6G


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 734 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   734 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |UNTREATD   |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  90.0  78.0  58.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |0.012%     |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  92.0  82.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.025%     |   100.0 100.0 100.0  98.0  94.0  94.0  92.0  88.0  72.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                UNTREATD         0.012%           0.025%        |
 |                                CONTROL                                         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       58.0%            60.0%            60.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.990N         P=0.853N         P=1.000N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       644.5            668.7            612.4         |
 |NATURAL DEATHS (C)      |       (17.3)           (12.2)           (24.7)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       696.4            707.9            685.3         |
 |(STANDARD ERROR)        |       ( 9.5)           ( 6.6)           (12.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            RHODAMINE 6G
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        0.012%           = 2
                                                        0.025%           = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                         3                        2      1
      |                                                           3             3          2 2    11
      |                                                                         3 3 3        2  2  11  1
      |                                                                             3              32  11 2
P  90 +                                                                                            3       3
E     |                                                                                                 1 13 3
R     |                                                                                                   2  233
C     |                                                                                                   1  22  1
E  80 +
N     |                                                                                                        3 11
T     |                                                                                                       22 33 3
      |                                                                                                        2 21 3 1
S  70 +
U     |
R     |                                                                                                          22  2
V     |                                                                                                               3 3
I  60 +                                                                                                              22 33
V     |                                                                                                                  33
A     |                                                                                                                   3 3
L     |                                                                                                               1 1
   50 +                                                                                                                 121
      |                                                                                                                  22
      |                                                                                                                   1 1
      |                                                                                                                     2
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 17 obs hidden.

                                                            RHODAMINE 6G
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        UNTREATD CONTROL = 1
                                                        0.012%           = 2
                                                        0.025%           = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1                                                        3      1                         2
      |                                                          3      1                   1
P  96 +                                                                 3 3                 11    22
E     |                                                                   3                 31     2   12
R     |                                                                                     3  3        2    2
C     |                                                                                        3   3   11
E  88 +                                                                                            3    1 31 2 2
N     |                                                                                                    1  12 2
T     |                                                                                                   33  11
      |                                                                                                    33  1 12
S  80 +                                                                                                           22
U     |                                                                                                     33   112  2
R     |                                                                                                      3   3
V     |                                                                                                           11
I  72 +                                                                                                          3 1  1   2
V     |
A     |                                                                                                               3   3
L     |                                                                                                               1   1
   64 +                                                                                                                   3 3
      |                                                                                                                   2 2
      |                                                                                                                   1 1
      |                                                                                                                     1
   56 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.

--multipart-boundary
Content-type: text/plain
Range: bytes 25015-25015/25015


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.