National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2723

TR 365 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                    PENTAERYTHRITOL TETRANITRATE


NTP Experiment-Test: 05023-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 02:05:42




       Facility:  TSI Mason Research

       Chemical CAS #:  78-11-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7           12            7                                                  
    Moribund                                           5            8            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           30           38                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (41)         (43)                                                
      Inflammation, Acute                                           1 (2%)                                                          
   Intestine Large, Colon                             (49)         (11)         (49)                                                
      Parasite                                                                   1 (2%)                                             
   Intestine Small, Duodenum                          (46)         (11)         (43)                                                
      Epithelium, Hyperplasia                          1 (2%)                    1 (2%)                                             
      Lymphoid Nodule, Hyperplasia                                  1 (9%)                                                          
   Intestine Small, Ileum                             (47)         (11)         (46)                                                
      Lymphoid Nodule, Mineralization                  1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (11)         (44)                                                
      Hyperplasia                                                   1 (9%)                                                          
   Liver                                              (49)         (50)         (49)                                                
      Basophilic Focus                                 1 (2%)       1 (2%)       2 (4%)                                             
      Clear Cell Focus                                 1 (2%)       3 (6%)       1 (2%)                                             
      Eosinophilic Focus                                                         3 (6%)                                             
      Fatty Change, Diffuse                            2 (4%)       1 (2%)                                                          
      Fatty Change, Focal                              1 (2%)       5 (10%)      2 (4%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              6 (12%)                                                         
      Hemorrhage                                                    1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         6 (12%)      3 (6%)       2 (4%)                                             
      Pigmentation                                     1 (2%)                    1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Mesentery                                                       (6)          (1)                                                 
      Inflammation, Acute                                           3 (50%)                                                         
      Fat, Necrosis                                                 3 (50%)                                                         
   Pancreas                                           (49)         (13)         (49)                                                
      Cyst                                                          1 (8%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)                    2 (4%)                                             
      Necrosis                                                                   2 (4%)                                             
      Acinus, Atrophy                                  2 (4%)       3 (23%)      3 (6%)                                             
      Acinus, Hypertrophy                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Dilatation                                              1 (8%)                                                          
   Stomach, Forestomach                               (49)         (50)         (49)                                                
      Acanthosis                                       2 (4%)       5 (10%)      4 (8%)                                             
      Edema                                                                      1 (2%)                                             
      Hyperkeratosis                                  11 (22%)     10 (20%)     13 (27%)                                            
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Necrosis                                                      2 (4%)                                                          
   Stomach, Glandular                                 (47)         (49)         (48)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)       4 (8%)      10 (21%)                                            
      Mineralization                                   2 (4%)       1 (2%)       1 (2%)                                             
   Tooth                                                                        (1)                                                 
      Incisor, Developmental Malformation                                        1 (100%)                                           
      Incisor, Inflammation, Acute                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (12)         (49)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (12)         (49)                                                
      Capsule, Hyperplasia                            40 (82%)      7 (58%)     43 (88%)                                            
   Adrenal Gland, Cortex                              (48)         (12)         (49)                                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                     36 (75%)      7 (58%)     38 (78%)                                            
      Hypertrophy                                      3 (6%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (47)         (11)         (47)                                                
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (49)         (12)         (48)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (45)         (15)         (42)                                                
      Pars Distalis, Angiectasis                       4 (9%)       2 (13%)      1 (2%)                                             
      Pars Distalis, Hyperplasia                       8 (18%)      2 (13%)     10 (24%)                                            
   Thyroid Gland                                      (47)         (12)         (47)                                                
      Follicular Cell, Hyperplasia                     1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (19)         (48)                                                
      Abscess                                                       2 (11%)                                                         
      Angiectasis                                                                3 (6%)                                             
      Cyst                                             9 (18%)      2 (11%)      9 (19%)                                            
      Degeneration, Cystic                             1 (2%)       6 (32%)      2 (4%)                                             
      Hemorrhage                                       1 (2%)       1 (5%)       2 (4%)                                             
      Hyperplasia, Papillary                           1 (2%)                                                                       
      Mineralization                                                             2 (4%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                                               2 (4%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Bilateral, Abscess                                            2 (11%)      1 (2%)                                             
   Uterus                                             (49)         (37)         (49)                                                
      Abscess                                                       1 (3%)                                                          
      Angiectasis                                      2 (4%)       1 (3%)                                                          
      Hemorrhage                                                    1 (3%)                                                          
      Inflammation, Chronic Active                     3 (6%)       3 (8%)       2 (4%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                                  1 (3%)                                                          
      Endometrium, Hyperplasia                        36 (73%)     19 (51%)     38 (78%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (12)         (49)                                                
      Myelofibrosis                                    5 (10%)                   4 (8%)                                             
   Lymph Node                                         (50)         (17)         (48)                                                
      Axillary, Hematopoietic Cell Proliferation                    1 (6%)                                                          
      Axillary, Infiltration Cellular, Plasma Cell                  1 (6%)                                                          
      Lumbar, Angiectasis                              1 (2%)                                                                       
      Lumbar, Hematopoietic Cell Proliferation                      1 (6%)                                                          
      Lumbar, Infiltration Cellular, Plasma Cell                    1 (6%)       1 (2%)                                             
      Mediastinal, Angiectasis                         1 (2%)                                                                       
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      2 (12%)                                                         
      Pancreatic, Hematopoietic Cell Proliferation                               1 (2%)                                             
      Renal, Hematopoietic Cell Proliferation                       1 (6%)                                                          
      Renal, Infiltration Cellular, Plasma Cell                     1 (6%)       1 (2%)                                             
   Lymph Node, Mandibular                             (40)         (8)          (42)                                                
      Hematopoietic Cell Proliferation                 2 (5%)       2 (25%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (3%)                                                                       
   Lymph Node, Mesenteric                             (48)         (12)         (46)                                                
      Angiectasis                                      3 (6%)       1 (8%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       3 (25%)      3 (7%)                                             
   Spleen                                             (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation                35 (70%)     20 (40%)     34 (68%)                                            
      Hemorrhage                                                                 1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Lymphoid Follicle, Hyperplasia                   4 (8%)       5 (10%)      2 (4%)                                             
   Thymus                                             (42)         (10)         (40)                                                
      Hyperplasia, Lymphoid                                         1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (5)          (34)                                                
      Necrosis                                                      1 (20%)                                                         
      Acinus, Hyperplasia                              1 (3%)                                                                       
   Skin                                               (49)         (13)         (46)                                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                                      1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (12)         (49)                                                
      Mineralization                                   5 (10%)                   2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (16)         (49)                                                
      Congestion                                       1 (2%)                                                                       
      Edema                                            2 (4%)                    1 (2%)                                             
      Hemorrhage                                       6 (12%)      1 (6%)       3 (6%)                                             
      Infiltration Cellular, Histiocyte                3 (6%)       1 (6%)                                                          
      Inflammation, Acute                                           1 (6%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    1 (2%)                                             
      Pleura, Inflammation, Acute                                                1 (2%)                                             
   Nose                                               (43)         (9)          (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Inflammation, Acute                        1 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (14)         (49)                                                
      Casts                                                                      1 (2%)                                             
      Cyst                                                                       2 (4%)                                             
      Glomerulosclerosis                                                         1 (2%)                                             
      Inflammation, Acute                                           1 (7%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Papilla, Mineralization                                       2 (14%)      1 (2%)                                             
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          15            6            9                                                  
    Dead                                               8            6            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           38           38                                                  
  Wrong Sex                                            1                                                                            
  Animals Examined Microscopically                    49           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (47)         (8)          (47)                                                
      Anus, Necrosis                                                             1 (2%)                                             
   Intestine Small, Ileum                             (44)         (6)          (47)                                                
      Lymphoid Nodule, Hyperplasia                     1 (2%)       1 (17%)      3 (6%)                                             
   Intestine Small, Jejunum                           (44)         (7)          (47)                                                
      Lymphoid Nodule, Hyperplasia                                  2 (29%)      2 (4%)                                             
   Liver                                              (48)         (24)         (49)                                                
      Angiectasis                                                   2 (8%)                                                          
      Clear Cell Focus                                                           1 (2%)                                             
      Cyst                                             1 (2%)       1 (4%)       2 (4%)                                             
      Eosinophilic Focus                               1 (2%)                                                                       
      Fatty Change, Diffuse                            1 (2%)                                                                       
      Fatty Change, Focal                              6 (13%)                                                                      
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                    1 (4%)                                                          
      Infarct                                          1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Mixed Cell Focus                                 1 (2%)                    2 (4%)                                             
      Necrosis                                         2 (4%)       3 (13%)      2 (4%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
   Mesentery                                          (4)          (4)          (2)                                                 
      Inflammation, Acute                              1 (25%)                                                                      
      Fat, Mineralization                              1 (25%)      1 (25%)      1 (50%)                                            
      Fat, Necrosis                                    3 (75%)      4 (100%)     2 (100%)                                           
   Pancreas                                           (47)         (13)         (47)                                                
      Acinus, Atrophy                                                            1 (2%)                                             
      Acinus, Necrosis                                 1 (2%)                                                                       
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (49)         (46)                                                
      Acanthosis                                       3 (6%)       1 (2%)                                                          
      Hyperkeratosis                                   3 (6%)       4 (8%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (47)         (47)         (47)                                                
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)       6 (13%)      6 (13%)                                            
      Mineralization                                   1 (2%)                                                                       
   Tooth                                              (1)                                                                           
      Incisor, Developmental Malformation              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (46)         (13)         (48)                                                
      Capsule, Hyperplasia                            37 (80%)     13 (100%)    45 (94%)                                            
   Adrenal Gland, Cortex                              (46)         (13)         (48)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                    1 (2%)                                             
      Hyperplasia                                      3 (7%)       1 (8%)       6 (13%)                                            
      Hypertrophy                                      7 (15%)      2 (15%)     13 (27%)                                            
   Adrenal Gland, Medulla                             (45)         (13)         (47)                                                
      Hyperplasia                                      4 (9%)       1 (8%)       8 (17%)                                            
   Islets, Pancreatic                                 (47)         (13)         (46)                                                
      Hyperplasia                                      3 (6%)                                                                       
   Pituitary Gland                                    (45)         (8)          (48)                                                
      Pars Distalis, Cyst                                                        5 (10%)                                            
      Pars Intermedia, Hyperplasia                     1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (46)         (8)          (46)                                                
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (19)         (19)         (18)                                                
      Atrophy                                                                    1 (6%)                                             
      Dilatation                                       8 (42%)      5 (26%)      9 (50%)                                            
      Inflammation, Acute                                                        1 (6%)                                             
      Inflammation, Chronic Active                     7 (37%)      6 (32%)      3 (17%)                                            
      Mineralization                                   1 (5%)       1 (5%)                                                          
      Necrosis                                         5 (26%)      6 (32%)      5 (28%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Prostate                                           (43)         (8)          (48)                                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Seminal Vesicle                                    (47)         (11)         (48)                                                
      Bacterium                                        1 (2%)                                                                       
      Concretion                                       1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
   Testes                                             (48)         (9)          (49)                                                
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Seminiferous Tubule, Atrophy                     2 (4%)                    1 (2%)                                             
      Seminiferous Tubule, Mineralization              1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (46)         (23)         (47)                                                
      Axillary, Angiectasis                            1 (2%)                                                                       
      Axillary, Infiltration Cellular, Lymphocyte      1 (2%)                                                                       
      Iliac, Cyst                                                   1 (4%)                                                          
      Lumbar, Hematopoietic Cell Proliferation         1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation                 1 (4%)                                                          
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      1 (4%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (4%)                                                          
      Pancreatic, Angiectasis                                       1 (4%)                                                          
      Renal, Hematopoietic Cell Proliferation          1 (2%)                                                                       
   Lymph Node, Mandibular                             (25)         (3)          (28)                                                
      Hematopoietic Cell Proliferation                                           1 (4%)                                             
   Lymph Node, Mesenteric                             (44)         (22)         (45)                                                
      Angiectasis                                     22 (50%)     18 (82%)     24 (53%)                                            
      Hematopoietic Cell Proliferation                15 (34%)     10 (45%)     20 (44%)                                            
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (5%)                                                          
   Spleen                                             (47)         (26)         (47)                                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Atrophy                                                       1 (4%)                                                          
      Depletion Lymphoid                                                         1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                38 (81%)     12 (46%)     36 (77%)                                            
      Hemorrhage                                                    2 (8%)                                                          
   Thymus                                             (36)         (7)          (42)                                                
      Atrophy                                          3 (8%)                                                                       
      Depletion Lymphoid                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (22)         (47)                                                
      Acanthosis                                       2 (4%)                    1 (2%)                                             
      Hemorrhage                                       2 (4%)                                                                       
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Acute                                           1 (5%)       1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Necrosis                                         6 (13%)      3 (14%)      4 (9%)                                             
      Prepuce, Fibrosis                                                          1 (2%)                                             
      Prepuce, Hemorrhage                              1 (2%)       1 (5%)                                                          
      Prepuce, Inflammation, Acute                     2 (4%)       2 (9%)                                                          
      Prepuce, Inflammation, Chronic Active                         1 (5%)                                                          
      Prepuce, Necrosis                                2 (4%)       2 (9%)       1 (2%)                                             
      Scrotal, Epithelium, Hyperplasia, Basal Cell     1 (2%)                                                                       
      Subcutaneous Tissue, Mineralization              1 (2%)                                                                       
      Subcutaneous Tissue, Necrosis                                 1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (48)         (31)         (50)                                                
      Joint, Hyperostosis                                           2 (6%)                                                          
      Tarsal, Hyperostosis                            23 (48%)     21 (68%)     25 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (9)          (50)                                                
      Mineralization                                   4 (8%)                    4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (47)         (17)         (50)                                                
      Atelectasis                                      1 (2%)                                                                       
      Congestion                                       2 (4%)       1 (6%)       4 (8%)                                             
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                       6 (13%)      1 (6%)       4 (8%)                                             
      Infiltration Cellular, Histiocyte                3 (6%)       3 (18%)      3 (6%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       1 (6%)       3 (6%)                                             
   Nose                                               (40)         (7)          (48)                                                
      Inflammation, Acute                              1 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05023-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 02:05:42  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (5)                                                 
      Hyperplasia                                                                1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (13)         (49)                                                
      Casts Protein                                                 1 (8%)       1 (2%)                                             
      Congestion                                       1 (2%)                    2 (4%)                                             
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Cortex, Mineralization                          12 (26%)      3 (23%)      8 (16%)                                            
      Papilla, Mineralization                          1 (2%)       1 (8%)       1 (2%)                                             
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Regeneration                                    1 (8%)                                                          
   Urinary Bladder                                    (45)         (15)         (47)                                                
      Angiectasis                                                                1 (2%)                                             
      Calculus Gross Observation                                    4 (27%)      2 (4%)                                             
      Calculus Micro Observation Only                  2 (4%)       5 (33%)      8 (17%)                                            
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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