National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2735

TR 365 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                    PENTAERYTHRITOL TETRANITRATE


NTP Experiment-Test: 05023-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 00:40:07




       Facility:  TSI Mason Research

       Chemical CAS #:  78-11-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          13           15           18                                                  
    Dead                                               3            2            1                                                  
    Natural Death                                      1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           33           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (44)         (49)                                                
      Hyperkeratosis                                                             1 (2%)                                             
   Intestine Large, Colon                             (48)         (10)         (50)                                                
      Parasite                                         5 (10%)                   7 (14%)                                            
   Intestine Large, Rectum                            (46)         (10)         (48)                                                
      Parasite                                         1 (2%)                                                                       
   Intestine Small, Ileum                             (46)         (13)         (49)                                                
      Lymphoid Nodule, Hyperplasia                                  2 (15%)      1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (10)         (49)                                                
      Lymphoid Nodule, Hyperplasia                                               1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                      1 (2%)       2 (4%)       3 (6%)                                             
      Basophilic Focus                                41 (82%)     41 (82%)     43 (86%)                                            
      Clear Cell Focus                                 1 (2%)       2 (4%)       1 (2%)                                             
      Congestion                                       1 (2%)                    1 (2%)                                             
      Developmental Malformation                       2 (4%)                    3 (6%)                                             
      Eosinophilic Focus                               1 (2%)       3 (6%)       1 (2%)                                             
      Fatty Change, Diffuse                            6 (12%)      5 (10%)      4 (8%)                                             
      Fatty Change, Focal                              4 (8%)       4 (8%)       8 (16%)                                            
      Focal Cellular Change                            2 (4%)                    3 (6%)                                             
      Hepatodiaphragmatic Nodule                       2 (4%)       7 (14%)      3 (6%)                                             
      Hyperplasia                                      1 (2%)       2 (4%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Mixed Cell Focus                                 3 (6%)       1 (2%)       3 (6%)                                             
      Necrosis                                         1 (2%)       2 (4%)       1 (2%)                                             
      Bile Duct, Hyperplasia                           4 (8%)       2 (4%)       2 (4%)                                             
   Mesentery                                          (3)          (4)          (4)                                                 
      Artery, Inflammation, Chronic Active                          1 (25%)                                                         
      Artery, Pigmentation                                          1 (25%)                                                         
      Artery, Thrombosis                                            1 (25%)                                                         
      Fat, Hemorrhage                                  1 (33%)                   1 (25%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    2 (67%)      2 (50%)      3 (75%)                                            
      Fat, Pigmentation                                             1 (25%)                                                         
   Pancreas                                           (50)         (17)         (49)                                                
      Acinus, Atrophy                                  1 (2%)                    1 (2%)                                             
      Artery, Inflammation, Chronic Active                          1 (6%)                                                          
   Pharynx                                            (1)                       (1)                                                 
      Palate, Epithelium, Hyperplasia                                            1 (100%)                                           
   Salivary Glands                                    (50)         (13)         (49)                                                
      Inflammation, Acute                                           1 (8%)                                                          
   Stomach, Forestomach                               (50)         (11)         (48)                                                
      Acanthosis                                       2 (4%)       1 (9%)       4 (8%)                                             
      Hyperkeratosis                                   2 (4%)       1 (9%)       7 (15%)                                            
      Inflammation, Chronic Active                                  2 (18%)                                                         
      Necrosis                                                      2 (18%)      1 (2%)                                             
   Stomach, Glandular                                 (50)         (11)         (50)                                                
      Hyperplasia                                                                4 (8%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Mineralization                                   2 (4%)                    2 (4%)                                             
      Necrosis                                         1 (2%)       1 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                                                
      Cardiomyopathy                                  28 (56%)      3 (30%)     23 (46%)                                            
      Artery, Necrosis, Fibrinoid                      1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (12)         (49)                                                
      Degeneration                                     1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
      Necrosis                                                                   1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (12)         (49)                                                
      Hyperplasia                                      6 (12%)      1 (8%)       7 (14%)                                            
      Necrosis                                                                   1 (2%)                                             
   Pituitary Gland                                    (50)         (30)         (49)                                                
      Hyperplasia                                      2 (4%)                                                                       
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
      Pars Distalis, Angiectasis                      28 (56%)     18 (60%)     26 (53%)                                            
      Pars Distalis, Cyst                              2 (4%)       3 (10%)      2 (4%)                                             
      Pars Distalis, Cyst, Multiple                    1 (2%)                                                                       
      Pars Distalis, Hemorrhage                                                  1 (2%)                                             
      Pars Distalis, Hyperplasia                      15 (30%)      3 (10%)     16 (33%)                                            
      Pars Distalis, Pigmentation                                                2 (4%)                                             
      Pars Intermedia, Hyperplasia                                  2 (7%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Nervosa, Cyst, Multiple                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Necrosis                                                                   1 (2%)                                             
      C-Cell, Hyperplasia                              7 (14%)      9 (19%)      5 (10%)                                            
      Follicular Cell, Hyperplasia                     1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (39)         (12)         (41)                                                
      Dilatation                                                                 1 (2%)                                             
      Hyperplasia                                      3 (8%)       1 (8%)       2 (5%)                                             
      Inflammation, Acute                                           1 (8%)                                                          
      Inflammation, Chronic Active                     1 (3%)       2 (17%)      2 (5%)                                             
      Necrosis                                         7 (18%)      1 (8%)       3 (7%)                                             
   Ovary                                              (50)         (15)         (50)                                                
      Cyst                                             4 (8%)       4 (27%)      3 (6%)                                             
   Uterus                                             (50)         (48)         (50)                                                
      Necrosis                                                                   2 (4%)                                             
      Pigmentation                                                  1 (2%)                                                          
      Endometrium, Hyperplasia                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (17)         (49)                                                
      Mediastinal, Angiectasis                         1 (2%)       1 (6%)                                                          
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Hemorrhage                                                    1 (2%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (6%)                                                          
      Mediastinal, Pigmentation                        2 (4%)                    3 (6%)                                             
      Pancreatic, Infiltration Cellular, Histiocyte                 2 (12%)                                                         
      Pancreatic, Pigmentation                         1 (2%)                                                                       
      Renal, Angiectasis                                            1 (6%)       1 (2%)                                             
      Renal, Infiltration Cellular, Histiocyte                      1 (6%)                                                          
   Lymph Node, Mandibular                             (46)         (11)         (47)                                                
      Angiectasis                                      1 (2%)                                                                       
      Degeneration, Cystic                                          1 (9%)                                                          
      Infiltration Cellular, Plasma Cell                            1 (9%)       2 (4%)                                             
   Lymph Node, Mesenteric                             (49)         (12)         (48)                                                
      Angiectasis                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                                 2 (4%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                             1 (8%)                                                          
      Necrosis                                                                   1 (2%)                                             
   Spleen                                             (49)         (26)         (50)                                                
      Angiectasis                                                                1 (2%)                                             
      Depletion Lymphoid                               1 (2%)       1 (4%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                33 (67%)     12 (46%)     41 (82%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Reticulum Cell                      1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (4%)       1 (2%)                                             
      Pigmentation                                    33 (67%)     10 (38%)     38 (76%)                                            
   Thymus                                             (46)         (10)         (44)                                                
      Depletion Lymphoid                                                         1 (2%)                                             
      Epithelial Cell, Hyperplasia                     2 (4%)                    2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (34)         (48)                                                
      Galactocele                                     35 (76%)     15 (44%)     32 (67%)                                            
      Acinus, Hyperplasia                              1 (2%)       1 (3%)       3 (6%)                                             
   Skin                                               (49)         (15)         (50)                                                
      Acanthosis                                       1 (2%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperkeratosis                                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hydrocephalus                                                 1 (10%)                                                         
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       4 (8%)      30 (60%)      2 (4%)                                             
      Edema                                            1 (2%)                    2 (4%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Hemorrhage                                       6 (12%)      3 (6%)       5 (10%)                                            
      Infiltration Cellular, Histiocyte                5 (10%)                   7 (14%)                                            
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (4%)                                                          
      Goblet Cell, Hypertrophy                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (2)                                                              
      Acanthosis                                       1 (50%)                                                                      
      Hyperkeratosis                                   2 (100%)                                                                     
   Eye                                                (6)          (7)          (5)                                                 
      Cornea, Inflammation, Chronic Active                                       1 (20%)                                            
      Lens, Cataract                                                1 (14%)                                                         
      Retina, Atrophy                                               2 (29%)                                                         
   Harderian Gland                                    (3)          (3)          (3)                                                 
      Abscess                                                                    1 (33%)                                            
      Pigmentation                                                               1 (33%)                                            
   Zymbal's Gland                                     (36)         (37)         (35)                                                
      Cyst                                                          1 (3%)       1 (3%)                                             
      Hyperplasia                                      1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Fibrosis                                                                   1 (2%)                                             
      Nephropathy                                     46 (92%)     39 (78%)     49 (98%)                                            
      Cortex, Mineralization                           4 (8%)       1 (2%)       7 (14%)                                            
      Cortex, Necrosis                                              1 (2%)                                                          
      Papilla, Mineralization                                       1 (2%)       4 (8%)                                             
      Pelvis, Mineralization                                        1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                                     1 (2%)       1 (2%)                                             
      Renal Tubule, Pigmentation                       1 (2%)       1 (2%)       2 (4%)                                             
      Transitional Epithelium, Hyperplasia                          2 (4%)                                                          
   Urinary Bladder                                    (49)         (10)         (49)                                                
      Hemorrhage                                                    1 (10%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                  1 (10%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          20           16           16                                                  
    Dead                                               8            5            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           28           29                                                  
    Moribund                                                        1                                                               
    Terminal Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (10)         (48)                                                
      Parasite                                         6 (13%)      2 (20%)     14 (29%)                                            
   Intestine Large, Rectum                            (46)         (9)          (48)                                                
      Parasite                                         1 (2%)                    2 (4%)                                             
   Intestine Small, Ileum                             (47)         (7)          (47)                                                
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
   Liver                                              (49)         (50)         (50)                                                
      Angiectasis                                      5 (10%)      7 (14%)      8 (16%)                                            
      Basophilic Focus                                25 (51%)     19 (38%)     25 (50%)                                            
      Clear Cell Focus                                 2 (4%)       4 (8%)       3 (6%)                                             
      Congestion                                       1 (2%)                    1 (2%)                                             
      Degeneration, Cystic                             3 (6%)       6 (12%)      6 (12%)                                            
      Developmental Malformation                                    2 (4%)       1 (2%)                                             
      Eosinophilic Focus                               1 (2%)       1 (2%)                                                          
      Fatty Change, Diffuse                            3 (6%)       1 (2%)       1 (2%)                                             
      Fatty Change, Focal                              7 (14%)      4 (8%)       5 (10%)                                            
      Focal Cellular Change                            2 (4%)                    8 (16%)                                            
      Hemorrhage                                                                 2 (4%)                                             
      Hepatodiaphragmatic Nodule                       4 (8%)       1 (2%)                                                          
      Hyperplasia                                      3 (6%)       2 (4%)                                                          
      Hyperplasia, Focal                               1 (2%)       1 (2%)       5 (10%)                                            
      Hyperplasia, Multifocal                                       1 (2%)       1 (2%)                                             
      Inflammation                                                               1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Mixed Cell Focus                                 4 (8%)       9 (18%)      3 (6%)                                             
      Necrosis                                         3 (6%)       1 (2%)       4 (8%)                                             
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                                    2 (4%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Bile Duct, Hyperplasia                          39 (80%)     31 (62%)     35 (70%)                                            
      Oval Cell, Hyperplasia                           1 (2%)                                                                       
   Mesentery                                          (5)          (2)          (9)                                                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hemorrhage                                                                 1 (11%)                                            
      Fat, Mineralization                              2 (40%)                   1 (11%)                                            
      Fat, Necrosis                                    2 (40%)      1 (50%)      6 (67%)                                            
      Fat, Pigmentation                                                          3 (33%)                                            
   Pancreas                                           (49)         (49)         (48)                                                
      Fibrosis                                                                   1 (2%)                                             
      Acinus, Atrophy                                  1 (2%)       2 (4%)                                                          
      Acinus, Hyperplasia                              3 (6%)       6 (12%)      2 (4%)                                             
      Acinus, Hyperplasia, Focal                                    1 (2%)       1 (2%)                                             
      Artery, Hemorrhage                                            1 (2%)                                                          
      Artery, Inflammation, Chronic Active                          2 (4%)                                                          
      Artery, Mineralization                           1 (2%)                                                                       
      Artery, Necrosis, Fibrinoid                      4 (8%)       2 (4%)       1 (2%)                                             
      Duct, Hyperplasia                                                          1 (2%)                                             
   Pharynx                                                                      (1)                                                 
      Palate, Epithelium, Hyperplasia                                            1 (100%)                                           
   Salivary Glands                                    (48)         (13)         (49)                                                
      Inflammation, Chronic Active                                  1 (8%)                                                          
   Stomach, Forestomach                               (49)         (14)         (48)                                                
      Acanthosis                                       3 (6%)       4 (29%)      2 (4%)                                             
      Edema                                            1 (2%)                    1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hyperkeratosis                                   4 (8%)                    7 (15%)                                            
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Inflammation, Chronic                                         2 (14%)                                                         
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Necrosis                                         2 (4%)                                                                       
      Ulcer                                                         2 (14%)                                                         
   Stomach, Glandular                                 (48)         (15)         (47)                                                
      Degeneration                                                               1 (2%)                                             
      Erosion                                                       3 (20%)                                                         
      Hyperplasia                                                                3 (6%)                                             
      Infiltration Cellular, Lymphocyte                             2 (13%)      2 (4%)                                             
      Inflammation, Chronic                                         2 (13%)                                                         
      Mineralization                                   1 (2%)                    2 (4%)                                             
      Necrosis                                         1 (2%)       1 (7%)       1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
   Tongue                                             (2)          (1)                                                              
      Hyperkeratosis                                   1 (50%)                                                                      
   Tooth                                              (1)                                                                           
      Gingiva, Inflammation, Chronic                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (15)         (50)                                                
      Cardiomyopathy                                  37 (76%)     13 (87%)     47 (94%)                                            
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Thrombosis                                                    3 (20%)                                                         
      Artery, Mineralization                           2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (18)         (48)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
      Hypertrophy                                                   1 (6%)                                                          
      Vacuolization Cytoplasmic, Diffuse                                         1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (18)         (48)                                                
      Hyperplasia                                     25 (51%)      5 (28%)     21 (44%)                                            
   Islets, Pancreatic                                 (49)         (45)         (47)                                                
      Hyperplasia                                                   2 (4%)                                                          
      Hyperplasia, Focal                                            1 (2%)                                                          
   Parathyroid Gland                                  (40)         (9)          (42)                                                
      Hyperplasia                                      2 (5%)                                                                       
   Pituitary Gland                                    (49)         (20)         (50)                                                
      Pars Distalis, Angiectasis                      12 (24%)     11 (55%)      6 (12%)                                            
      Pars Distalis, Cyst                              2 (4%)                                                                       
      Pars Distalis, Hyperplasia                      10 (20%)      3 (15%)     21 (42%)                                            
      Pars Distalis, Hyperplasia, Focal                1 (2%)                                                                       
      Pars Intermedia, Hyperplasia                     1 (2%)       1 (5%)       3 (6%)                                             
   Thyroid Gland                                      (49)         (15)         (50)                                                
      C-Cell, Hyperplasia                              4 (8%)                    6 (12%)                                            
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
      Necrosis                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (13)         (50)                                                
      Mineralization                                   4 (8%)                                                                       
   Preputial Gland                                    (46)         (22)         (50)                                                
      Dilatation                                       1 (2%)                    1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Acute                                           2 (9%)                                                          
      Inflammation, Chronic Active                     2 (4%)                    3 (6%)                                             
      Necrosis                                         7 (15%)      1 (5%)       7 (14%)                                            
   Prostate                                           (48)         (13)         (50)                                                
      Inflammation                                                               1 (2%)                                             
      Inflammation, Chronic Active                    12 (25%)      3 (23%)      9 (18%)                                            
      Mineralization                                                             1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Epithelium, Hyperplasia                          1 (2%)                    4 (8%)                                             
   Seminal Vesicle                                    (49)         (23)         (50)                                                
      Atrophy                                          3 (6%)                                                                       
   Testes                                             (49)         (50)         (50)                                                
      Interstitial Cell, Hyperplasia                  28 (57%)     23 (46%)     25 (50%)                                            
      Seminiferous Tubule, Atrophy                    43 (88%)     32 (64%)     44 (88%)                                            
      Seminiferous Tubule, Mineralization              4 (8%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (10)         (50)                                                
      Hyperplasia, Reticulum Cell                                                1 (2%)                                             
   Lymph Node                                         (48)         (30)         (50)                                                
      Axillary, Infiltration Cellular, Plasma Cell                  1 (3%)                                                          
      Inguinal, Infiltration Cellular, Plasma Cell                  1 (3%)                                                          
      Lumbar, Congestion                               1 (2%)                                                                       
      Lumbar, Infiltration Cellular, Plasma Cell       1 (2%)                                                                       
      Lumbar, Infiltration Cellular, Histiocyte                     1 (3%)                                                          
      Lumbar, Pigmentation                                                       1 (2%)                                             
      Mediastinal, Angiectasis                         2 (4%)       2 (7%)                                                          
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Depletion Lymphoid                                            1 (2%)                                             
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (3%)                                                          
      Mediastinal, Pigmentation                        3 (6%)       1 (3%)       2 (4%)                                             
      Pancreatic, Angiectasis                                       1 (3%)                                                          
      Pancreatic, Cyst                                                           1 (2%)                                             
      Pancreatic, Depletion Lymphoid                                             1 (2%)                                             
      Pancreatic, Hematocyst                                                     1 (2%)                                             
      Pancreatic, Hemorrhage                                                     1 (2%)                                             
      Pancreatic, Infiltration Cellular, Plasma                                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
          Cell                                         1 (2%)                    1 (2%)                                             
      Pancreatic, Infiltration Cellular, Histiocyte                 3 (10%)      1 (2%)                                             
      Renal, Infiltration Cellular, Histiocyte                      2 (7%)       1 (2%)                                             
      Renal, Pigmentation                              1 (2%)                    2 (4%)                                             
   Lymph Node, Mandibular                             (46)         (20)         (49)                                                
      Angiectasis                                                   1 (5%)                                                          
      Cyst                                             4 (9%)                    2 (4%)                                             
      Degeneration, Cystic                                          1 (5%)       1 (2%)                                             
      Erythrophagocytosis                              1 (2%)                                                                       
      Hemorrhage                                       2 (4%)                                                                       
      Infiltration Cellular, Plasma Cell                            2 (10%)                                                         
   Lymph Node, Mesenteric                             (47)         (15)         (48)                                                
      Angiectasis                                                   1 (7%)       1 (2%)                                             
      Degeneration, Cystic                             1 (2%)                    2 (4%)                                             
      Hemorrhage                                       1 (2%)       1 (7%)       1 (2%)                                             
      Infiltration Cellular, Plasma Cell               1 (2%)       1 (7%)                                                          
      Infiltration Cellular, Histiocyte                                          2 (4%)                                             
      Necrosis                                                                   1 (2%)                                             
   Spleen                                             (48)         (36)         (50)                                                
      Atrophy                                                                    1 (2%)                                             
      Congestion                                       2 (4%)                                                                       
      Depletion Lymphoid                               1 (2%)       1 (3%)       2 (4%)                                             
      Fibrosis                                         1 (2%)       2 (6%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                26 (54%)     14 (39%)     28 (56%)                                            
      Hemorrhage                                                    4 (11%)                                                         
      Mineralization                                                1 (3%)                                                          
      Necrosis                                         1 (2%)       1 (3%)                                                          
      Pigmentation                                     6 (13%)      2 (6%)      15 (30%)                                            
      Thrombosis                                                    1 (3%)                                                          
   Thymus                                             (36)         (17)         (45)                                                
      Depletion Lymphoid                               3 (8%)       1 (6%)       3 (7%)                                             
      Epithelial Cell, Hyperplasia                     1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (37)         (9)          (38)                                                
      Galactocele                                      4 (11%)                   6 (16%)                                            
      Acinus, Hyperplasia                              1 (3%)                    1 (3%)                                             
   Skin                                               (48)         (18)         (50)                                                
      Acanthosis                                       3 (6%)       4 (22%)      4 (8%)                                             
      Cyst Epithelial Inclusion                                     2 (11%)                                                         
      Erosion                                                                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                   4 (8%)       4 (22%)      5 (10%)                                            
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                         2 (4%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (10)         (50)                                                
      Tarsal, Hyperostosis                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (48)         (50)                                                
      Hemorrhage                                       3 (6%)       1 (2%)       2 (4%)                                             
   Spinal Cord                                                     (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (28)         (50)                                                
      Atelectasis                                      1 (2%)       1 (4%)                                                          
      Congestion                                      10 (20%)     10 (36%)     11 (22%)                                            
      Edema                                            3 (6%)       1 (4%)       2 (4%)                                             
      Embolus Tumor                                    1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                       6 (12%)      2 (7%)       6 (12%)                                            
      Infiltration Cellular, Histiocyte                4 (8%)       1 (4%)      11 (22%)                                            
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                    5 (10%)                                            
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    1 (2%)                                             
   Nose                                               (47)         (10)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                              2 (4%)                    8 (16%)                                            
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (9)          (6)                                                 
      Cornea, Inflammation, Acute                      1 (20%)                                                                      
      Lens, Cataract                                   1 (20%)      3 (33%)      1 (17%)                                            
   Zymbal's Gland                                     (49)         (45)         (41)                                                
      Cyst                                             6 (12%)      1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Granulomatous                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05023-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:07  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             4 (8%)       1 (2%)       1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hydronephrosis                                                             2 (4%)                                             
      Necrosis                                                      1 (2%)                                                          
      Nephropathy                                     49 (100%)    49 (98%)     49 (98%)                                            
      Capsule, Fibrosis                                                          1 (2%)                                             
      Cortex, Mineralization                           5 (10%)                   7 (14%)                                            
      Papilla, Mineralization                          4 (8%)       1 (2%)       9 (18%)                                            
      Renal Tubule, Dilatation                                                   1 (2%)                                             
      Renal Tubule, Hyperplasia                                     3 (6%)                                                          
      Renal Tubule, Necrosis                           1 (2%)                    1 (2%)                                             
      Renal Tubule, Pigmentation                       3 (6%)       1 (2%)       5 (10%)                                            
      Transitional Epithelium, Hyperplasia             2 (4%)       8 (16%)      3 (6%)                                             
   Urinary Bladder                                    (46)         (10)         (48)                                                
      Calculus Gross Observation                                    1 (10%)      1 (2%)                                             
      Calculus Micro Observation Only                  1 (2%)       2 (20%)      1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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