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TR 365 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                    PENTAERYTHRITOL TETRANITRATE


NTP Experiment-Test: 05023-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 00:40:08




       Facility:  TSI Mason Research

       Chemical CAS #:  78-11-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          13           15           18                                                  
    Dead                                               3            2            1                                                  
    Natural Death                                      1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           33           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (10)         (50)                                                
   Intestine Small, Duodenum                          (48)         (11)         (49)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (46)         (13)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Pancreas                                           (50)         (17)         (49)                                                
      Acinus, Adenoma                                               1 (6%)       1 (2%)                                             
   Pharynx                                            (1)                       (1)                                                 
      Palate, Squamous Cell Carcinoma                  1 (100%)                                                                     
   Salivary Glands                                    (50)         (13)         (49)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Stomach, Glandular                                 (50)         (11)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (12)         (49)                                                
   Adrenal Gland, Medulla                             (49)         (12)         (49)                                                
      Pheochromocytoma Benign                          1 (2%)                    4 (8%)                                             
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (17)         (48)                                                
      Adenoma                                          1 (2%)       1 (6%)                                                          
   Parathyroid Gland                                  (43)         (36)         (44)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (30)         (49)                                                
      Pars Distalis, Adenoma                          16 (32%)     13 (43%)     18 (37%)                                            
                                                             Page   2                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma, Multiple                 3 (6%)       1 (3%)       5 (10%)                                            
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Bilateral, C-Cell, Adenoma                       2 (4%)                                                                       
      C-Cell, Adenoma                                  5 (10%)      3 (6%)       4 (8%)                                             
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       3 (6%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (39)         (12)         (41)                                                
      Adenoma                                          5 (13%)      4 (33%)      6 (15%)                                            
      Carcinoma                                                     1 (8%)       1 (2%)                                             
      Bilateral, Adenoma                                            2 (17%)                                                         
   Ovary                                              (50)         (15)         (50)                                                
      Granulosa Cell Tumor Benign                                   1 (7%)                                                          
   Uterus                                             (50)         (48)         (50)                                                
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    8 (16%)      9 (19%)     12 (24%)                                            
      Bilateral, Polyp Stromal                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (50)                                                
   Lymph Node                                         (50)         (17)         (49)                                                
   Lymph Node, Mandibular                             (46)         (11)         (47)                                                
   Lymph Node, Mesenteric                             (49)         (12)         (48)                                                
   Spleen                                             (49)         (26)         (50)                                                
   Thymus                                             (46)         (10)         (44)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (34)         (48)                                                
      Adenocarcinoma                                                1 (3%)       2 (4%)                                             
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                    18 (39%)     15 (44%)     18 (38%)                                            
      Fibroadenoma, Multiple                           9 (20%)      8 (24%)     11 (23%)                                            
                                                             Page   3                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
   Skin                                               (49)         (15)         (50)                                                
      Keratoacanthoma                                  1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     4 (8%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (7%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (7%)                                                          
      Subcutaneous Tissue, Hemangioma                               1 (7%)                                                          
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                                                
      Astrocytoma Malignant                                         1 (10%)                                                         
   Spinal Cord                                        (1)          (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Nose                                               (50)         (10)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (2)                                                              
      Basosquamous Tumor Benign                        1 (50%)                                                                      
      Fibrosarcoma                                                  1 (50%)                                                         
   Zymbal's Gland                                     (36)         (37)         (35)                                                
      Adenoma                                                                    2 (6%)                                             
      Carcinoma                                                     1 (3%)       1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (49)         (10)         (49)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            14 (28%)     14 (28%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.62%        1.25%                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          47          50                                                   
     Total Primary Neoplasms                           95          83         106                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          40          47                                                   
     Total Benign Neoplasms                            78          61          84                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          20          18                                                   
     Total Malignant Neoplasms                         17          22          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                                   
     Total Metastatic Neoplasm                                      2           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          20           16           16                                                  
    Dead                                               8            5            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           28           29                                                  
    Moribund                                                        1                                                               
    Terminal Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (8)          (47)                                                
   Intestine Large, Colon                             (47)         (10)         (48)                                                
   Intestine Small, Duodenum                          (48)         (9)          (46)                                                
   Intestine Small, Ileum                             (47)         (7)          (47)                                                
   Intestine Small, Jejunum                           (45)         (9)          (46)                                                
   Liver                                              (49)         (50)         (50)                                                
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Neoplastic Nodule                                2 (4%)                    1 (2%)                                             
   Mesentery                                          (5)          (2)          (9)                                                 
   Pancreas                                           (49)         (49)         (48)                                                
      Mixed Tumor Benign                               1 (2%)                                                                       
      Acinus, Adenoma                                  1 (2%)       4 (8%)       3 (6%)                                             
      Acinus, Adenoma, Multiple                                     1 (2%)                                                          
   Salivary Glands                                    (48)         (13)         (49)                                                
   Stomach, Forestomach                               (49)         (14)         (48)                                                
   Stomach, Glandular                                 (48)         (15)         (47)                                                
   Tongue                                             (2)          (1)                                                              
      Squamous Cell Papilloma                          2 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (15)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (18)         (48)                                                
   Adrenal Gland, Medulla                             (49)         (18)         (48)                                                
      Pheochromocytoma Malignant                                    2 (11%)      3 (6%)                                             
      Pheochromocytoma Benign                         12 (24%)      8 (44%)     11 (23%)                                            
                                                             Page   7                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign               7 (14%)                   4 (8%)                                             
   Islets, Pancreatic                                 (49)         (45)         (47)                                                
      Adenoma                                          6 (12%)      2 (4%)       1 (2%)                                             
      Adenoma, Multiple                                             1 (2%)                                                          
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (49)         (20)         (50)                                                
      Pars Distalis, Adenoma                          13 (27%)     11 (55%)     11 (22%)                                            
      Pars Distalis, Adenoma, Multiple                              1 (5%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (15)         (50)                                                
      C-Cell, Adenoma                                  5 (10%)      2 (13%)      7 (14%)                                            
      C-Cell, Carcinoma                                                          2 (4%)                                             
      Follicular Cell, Adenoma                                      1 (7%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)       1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (48)         (13)         (50)                                                
   Preputial Gland                                    (46)         (22)         (50)                                                
      Adenoma                                         11 (24%)     10 (45%)     13 (26%)                                            
      Carcinoma                                        3 (7%)       1 (5%)       1 (2%)                                             
      Bilateral, Adenoma                                            1 (5%)                                                          
      Bilateral, Carcinoma                                          1 (5%)                                                          
   Prostate                                           (48)         (13)         (50)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Seminal Vesicle                                    (49)         (23)         (50)                                                
   Testes                                             (49)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           39 (80%)     36 (72%)     42 (84%)                                            
      Interstitial Cell, Adenoma                       8 (16%)      8 (16%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (10)         (50)                                                
   Lymph Node                                         (48)         (30)         (50)                                                
   Lymph Node, Mandibular                             (46)         (20)         (49)                                                
      Liposarcoma, Metastatic, Skin                    1 (2%)                                                                       
   Lymph Node, Mesenteric                             (47)         (15)         (48)                                                
   Spleen                                             (48)         (36)         (50)                                                
   Thymus                                             (36)         (17)         (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (37)         (9)          (38)                                                
      Adenocarcinoma                                   1 (3%)                    1 (3%)                                             
      Fibroadenoma                                     3 (8%)       1 (11%)      1 (3%)                                             
      Fibroadenoma, Multiple                           1 (3%)                                                                       
   Skin                                               (48)         (18)         (50)                                                
      Basal Cell Adenoma                                                         1 (2%)                                             
      Keratoacanthoma                                  3 (6%)                    1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (6%)                                                          
      Squamous Cell Papilloma                          1 (2%)       1 (6%)       1 (2%)                                             
      Scrotal, Fibroma                                              1 (6%)                                                          
      Subcutaneous Tissue, Fibroma                     4 (8%)       2 (11%)      1 (2%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)                                             
      Subcutaneous Tissue, Liposarcoma                 1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Tail, Keratoacanthoma                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (48)         (50)                                                
      Astrocytoma Malignant                                                      2 (4%)                                             
      Cerebellum, Carcinoma, Metastatic, Zymbal's                                                                                   
          Gland                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (28)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       3 (11%)      4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                         1 (4%)                                                          
      Carcinoma Adenosquamous                          1 (2%)                                                                       
      Liposarcoma, Metastatic, Skin                    1 (2%)                                                                       
   Nose                                               (47)         (10)         (50)                                                
      Chondroma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (3)                                                 
      Sarcoma                                                       1 (100%)                                                        
   Eye                                                (5)          (9)          (6)                                                 
   Zymbal's Gland                                     (49)         (45)         (41)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                     2 (4%)       2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Renal Tubule, Adenoma                                                      1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (46)         (10)         (48)                                                
      Adenocarcinoma, Metastatic, Prostate                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            29 (58%)     27 (54%)     20 (40%)                                            
      Mesothelioma Malignant                           1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05023-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 00:40:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.5%         5.0%                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          50                                                   
     Total Primary Neoplasms                          163         133         151                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          48          50                                                   
     Total Benign Neoplasms                           123          96         114                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          32          31                                                   
     Total Malignant Neoplasms                         40          37          37                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           2                                                   
     Total Metastatic Neoplasm                          2           1           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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