National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2743

TR 365 Rat Pathology Tables

NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97
Route: DOSED FEED                                                                                                 Time: 12:56:45




       Facility:  TSI Mason Research

       Chemical CAS #:  78-11-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |                                                                1         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +|             
      Parasite                             |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X        X  X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |             2                                                            |             
      Developmental Malformation           |                                                    X                 X   |             
      Eosinophilic Focus                   |                                                             X            |             
      Fatty Change, Diffuse                |             1                          2              2  2               |             
      Fatty Change, Focal                  |                               1  1              1                        |             
      Focal Cellular Change                |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic, Focal         |                                     1                                    |             
      Inflammation, Chronic Active         |                                                 1                        |             
      Inflammation, Granulomatous          |    1                                                                     |             
      Mixed Cell Focus                     |                         X        X                                       |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |                         2                          2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                    +                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |          2                    3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       |                                                          1               |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2           2        2           1        2     2  1  2     2   |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |    2                                                                     |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                              2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                             2            |             
      Hyperplasia                          |          2                                                               |             
      Pars Distalis, Angiectasis           | 4     2           2  1  2  2  1  2  2     3  2  2        1  1     2     2|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Cyst, Multiple        |          X                                                               |             
      Pars Distalis, Hyperplasia           |    2  2     3  2     2                                2  2           1  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                          1                 1              2  2   |             
      Follicular Cell, Hyperplasia         | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
      Inflammation, Chronic Active         |                                                                2         |             
      Necrosis                             |    2              3  2                       3                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                    X                                            X      |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Pigmentation            |                                                    2                     |             
      Pancreatic, Pigmentation             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Angiectasis                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |       2     2     1  2  2     2  2  2     2  2  2  2  2     2     2     2|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Necrosis                             |                                                          2               |             
      Pigmentation                         | 2  2  2  2  2  2  2  2  2  3  2     2     2  2  2  2        2  2  2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                                                 2              2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Galactocele                          | X  X  X     X  X  X  X  X  X  X  X  X     X  X     X     X        X  X  X|             
      Acinus, Hyperplasia                  |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               3                                          |             
      Hemorrhage                           |                               2                                          |             
      Hyperkeratosis                       |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                2         |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                  1     1                                 |             
      Infiltration Cellular, Histiocyte    |                      1                                                   |             
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                             +           +                    +         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  M  M  +  +|             
      Hyperplasia                          |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  1  2  1  2  2  2  1  3  2  3  1  1  1  3  2  1  1  1  1  1  2  2  1|             
      Cortex, Mineralization               |                1                                            1            |             
      Renal Tubule, Pigmentation           |          1                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6|            |
                                           | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite                             |       1                             2              2                    2|      5  1.6|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              1                           |      1  1.0|
      Basophilic Focus                     | X     X     X  X     X  X  X  X  X  X        X  X  X  X  X     X  X  X  X|     41     |
      Clear Cell Focus                     |                                     X                                    |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                                                                          |      2     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change, Diffuse                |          3           2                                                   |      6  2.0|
      Fatty Change, Focal                  |                               1                                          |      4  1.0|
      Focal Cellular Change                |                                              X        X                  |      2     |
      Hepatodiaphragmatic Nodule           |                                     X                                    |      2     |
      Hyperplasia                          |    2                                                                     |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                X         |      3     |
      Necrosis                             |                                              1                           |      1  1.0|
      Bile Duct, Hyperplasia               |          2              1                                                |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   3        |
      Fat, Hemorrhage                      |                         2                                                |      1  2.0|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                             +            |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                      2                                                  1|      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6|            |
                                           | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |          2           1                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                                   2      |      1  2.0|
      Mineralization                       |                                                                   1      |      2  1.0|
      Necrosis                             |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2        1  2  2     2  2  2  2     2  2  2  2  2  2  2  2  2        2|     28  1.9|
      Artery, Necrosis, Fibrinoid          |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Degeneration                         |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Hyperplasia                          |          1                          1                             1     1|      6  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                   2      |      2  2.0|
      Pars Distalis, Angiectasis           | 2        2  2  2              2        3     2  2  3     2        2     2|     28  2.0|
      Pars Distalis, Cyst                  |                                              X                 X         |      2     |
      Pars Distalis, Cyst, Multiple        |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |       3  2     2                 2     2  2                              |     15  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                  1                                      1|      7  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +|  39        |
      Hyperplasia                          |          2                                                              1|      3  1.7|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Necrosis                             |                                              2           3     2         |      7  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6|            |
                                           | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                             X            |      4     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                +     +                                                   |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Angiectasis             |                                                                          |      1  1.0|
      Mediastinal, Pigmentation            |       1                                                                  |      2  1.5|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                                   1      |      1  1.0|
      Fibrosis                             |                         1                                                |      1  1.0|
      Hematopoietic Cell Proliferation     | 2  1  1  2  3  1  2        2     2  2           2        2  1  2  2  2  2|     33  1.9|
      Hemorrhage                           |                         3                                                |      1  3.0|
      Hyperplasia, Reticulum Cell          |       3                                                                  |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         | 2  2           2  2     1     2              2  2     2  2  2  2        2|     33  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Epithelial Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Galactocele                          | X  X  X  X     X  X  X        X  X              X  X     X  X  X  X     X|     35     |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |    4                                                                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6|            |
                                           | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                   1                                               2      |      4  1.8|
      Edema                                |                         1                                                |      1  1.0|
      Hemorrhage                           | 1                    1     1           2                                 |      6  1.2|
      Infiltration Cellular, Histiocyte    | 1           1              1     1                                       |      5  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                             +                                          |   2        |
      Acanthosis                           |                               3                                          |      1  3.0|
      Hyperkeratosis                       | 3                             4                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                 +|   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  +  M  M  +  M  +  +  M  +  +  +  M  +  M  +  +  +  M  M  +|  36        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 2  2  2  1     2  2  2  1     2  2  1        2  2  2  2  2  2  1  1  1  2|     46  1.7|
      Cortex, Mineralization               |                               1              1                           |      4  1.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|             
                                           | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.62%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +              +                    +        +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +              +                    +        +              +|             
      Lymphoid Nodule, Hyperplasia         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X     X  X  X  X  X  X  X  X  X        X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |       X                                                                  |             
      Eosinophilic Focus                   |       X                                                                  |             
      Fatty Change, Diffuse                |                         2                 3                              |             
      Fatty Change, Focal                  |                                     1                 2     1           2|             
      Hepatodiaphragmatic Nodule           |             X              X           X                                 |             
      Hyperplasia                          |                         2        1                                       |             
      Mixed Cell Focus                     |          X                                                               |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                  +               |             
      Artery, Inflammation, Chronic Active |       1                                                                  |             
      Artery, Pigmentation                 |       2                                                                  |             
      Artery, Thrombosis                   |       3                                                                  |             
      Fat, Necrosis                        |                                                          3               |             
      Fat, Pigmentation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +  +           +     +                       +     +        +|             
      Artery, Inflammation, Chronic Active |       2                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +              +     +                       +              +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +              +                             +              +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +              +                             +              +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +              +                             +              +|             
      Cardiomyopathy                       |                            2                             2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|             
                                           | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.62%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +              +                             +              +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +  +           +     +                       +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  M  +     +  +  +     +  +  +     +  +     +  +  +  +  +     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +        +  +  +     +  +     +              +           +  +|             
      Pars Distalis, Angiectasis           | 3                                3  3     2                          3  2|             
      Pars Distalis, Cyst                  |             X        X                                                   |             
      Pars Distalis, Hyperplasia           |             2                                                            |             
      Pars Intermedia, Hyperplasia         |                            1                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      C-Cell, Hyperplasia                  |    2  1                       1  2                             1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             M  +           +           +                 M        +     +|             
      Hyperplasia                          |                            2                                             |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Necrosis                             |                            3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +              +     +                       +              +|             
      Cyst                                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +              +     +                       +              +|             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       2                                                                  |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |       2                                                                  |             
      Renal, Angiectasis                   |       2                                                                  |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             M              M     +                       +              M|             
      Degeneration, Cystic                 |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|             
                                           | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.62%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +              +                             +              +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +           +  +     +     +  +     +     +  +  +        +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |          2  2                          2        2     2                  |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                            2                    3                    3   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     +              +                             +              +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +     +     +  +     +        +  +     +     +  +     +  +  +|             
      Galactocele                          |    X     X              X        X           X                       X   |             
      Acinus, Hyperplasia                  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    |             +              +  +                          +        +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +              +                             +              +|             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2  2  2  2        2  2     2  2        2     2  2  2        2  2  2  2   |             
      Fibrosis                             |                                                       3                  |             
      Hemorrhage                           |                                                 1                        |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Nose                                    |             +              +                             +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                              +                          +|             
                                            __________________________________________________________________________|             
   Eye                                     |       +                 +           +                                   +|             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                         2           2                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                       +                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | M  M  M  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|             
                                           | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.62%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2     2  1     2  2  2        2  2  2  1  2  2  1  1     2  2  2      |             
      Cortex, Mineralization               |                                                                          |             
      Cortex, Necrosis                     |                                           2                              |             
      Papilla, Mineralization              |                                                                          |             
      Pelvis, Mineralization               |             1                                                            |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                         2|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +              +                             +              +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.62%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +        +  +  +              +                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +        +  +  M              +                              |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +        +  +  +              +                              |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +        +  +  +              +                              |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +        +  +  +              +                             +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +        +  +  +              +                              |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +  +        +  +  +              +                             +|  13        |
      Lymphoid Nodule, Hyperplasia         |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +        +  +  +              +                              |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1                                   2                                    |      2  1.5|
      Basophilic Focus                     | X  X     X     X  X  X     X  X  X  X  X     X  X  X  X     X  X  X  X  X|     41     |
      Clear Cell Focus                     |                                                 X                        |      2     |
      Eosinophilic Focus                   |    X                                                           X         |      3     |
      Fatty Change, Diffuse                |       3                 3                 2                              |      5  2.6|
      Fatty Change, Focal                  |                                                                          |      4  1.5|
      Hepatodiaphragmatic Nodule           |    X                 X                       X  X                        |      7     |
      Hyperplasia                          |                                                                          |      2  1.5|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                            3                                      1      |      2  2.0|
      Bile Duct, Hyperplasia               |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                  +                  |   4        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Artery, Pigmentation                 |                                                                          |      1  2.0|
      Artery, Thrombosis                   |                                                                          |      1  3.0|
      Fat, Necrosis                        |    3                                                                     |      2  3.0|
      Fat, Pigmentation                    |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +        +  +  +              +  +              +            |  17        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +        +  +  +              +                              |  13        |
      Inflammation, Acute                  |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +        +  +  +              +                              |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +        +  +  +              +                              |  11        |
      Acanthosis                           |       3                                                                  |      1  3.0|
      Hyperkeratosis                       |       3                                                                  |      1  3.0|
      Inflammation, Chronic Active         |       2                 1                                                |      2  1.5|
      Necrosis                             |       2                                   2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +        +  +  +              +                              |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.62%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +        +  +  +              +                              |  10        |
      Cardiomyopathy                       |                            2                                             |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +  +     +  +  +              +                              |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +  +     +  +  +              +                              |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +  +     +  +  +              +                              |  12        |
      Hyperplasia                          |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +        +  +  +           +  +  +              +            |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  +  +  M  M  +  +  +     +  M  +     +  +  +  +  +  +  +  +|  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +           +  +     +        +|  30        |
      Pars Distalis, Angiectasis           |       2  2     2  3  3  2     2  2                    1  3     2        2|     18  2.3|
      Pars Distalis, Cyst                  | X                                                                        |      3     |
      Pars Distalis, Hyperplasia           |                   2                                      2               |      3  2.0|
      Pars Intermedia, Hyperplasia         | 2                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |    2              1           1                                      1   |      9  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +  M     +  +  M  M     +  +     +     +                        |  12        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                 2                        |      1  2.0|
      Inflammation, Chronic Active         |                                  1                                       |      2  1.5|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +     +  +  +              +        +     +               |  15        |
      Cyst                                 |                            X              X        X                     |      4     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pigmentation                         |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +        +  +  +              +                              |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +     +  +  +  +              +  +        +                  |  17        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.62%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Angiectasis             |                   3                                                      |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                              2                           |      2  2.0|
      Renal, Angiectasis                   |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +     +  +  +  +              +                              |  11        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +        +  +  +              +  +        +                  |  12        |
      Infiltration Cellular, Histiocyte    |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +     +  +  +              +        +  +  +     +         |  26        |
      Depletion Lymphoid                   |       2                                                                  |      1  2.0|
      Hematopoietic Cell Proliferation     |          1     3     3     2              2        2           2         |     12  2.1|
      Necrosis                             |                         3                                                |      1  3.0|
      Pigmentation                         | 2     3  2  3  2                                   2           2         |     10  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +        +  +  +              M                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +        +   |  34        |
      Galactocele                          |          X        X  X        X              X  X  X     X           X   |     15     |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +  +     +  +  +        +     +                             +|  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +        +  +  +              +                              |  10        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +        +  +  +              +                              |  10        |
      Hydrocephalus                        |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 2  2  2     3  2  3        2  2  2  2  3     2              2           2|     30  2.1|
      Fibrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|            |
                                           | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.62%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                2                                1                        |      3  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +        +  +  +              +                              |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +     +     +  +  +  +  +  +     +        +  +  +  +  +  +  +  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                    +     +                     |   7        |
      Lens, Cataract                       |                                                    2                     |      1  2.0|
      Retina, Atrophy                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  M  +  +  +  +  +  +  +  +  +|  37        |
      Cyst                                 |       X                                                                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 2  2  4  3     1  2  1  2     2  2     1     1  1  3  1  2  1  2  1  1  2|     39  1.8|
      Cortex, Mineralization               |             1                                                            |      1  1.0|
      Cortex, Necrosis                     |                                                                          |      1  2.0|
      Papilla, Mineralization              |                1                                                         |      1  1.0|
      Pelvis, Mineralization               |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                                                                         2|      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |       1                 2                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +        +  +  +              +                              |  10        |
      Hemorrhage                           |                         2                                                |      1  2.0|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|             
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |          2                                                           1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       1              2   |             
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                X                                                         |             
      Congestion                           |                         2                                                |             
      Developmental Malformation           |                                              X              X            |             
      Eosinophilic Focus                   |                               X                                          |             
      Fatty Change, Diffuse                |             2           2                                                |             
      Fatty Change, Focal                  |                   1        2  1              1           2               |             
      Focal Cellular Change                |                                        X     X                           |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                      X  X                          X                     |             
      Necrosis                             |                            2                                             |             
      Bile Duct, Hyperplasia               |             2                       2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                       +|             
      Fat, Hemorrhage                      | 3                                                                        |             
      Fat, Necrosis                        |                                                                         1|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                         2                                                |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2     1           1         |             
      Mineralization                       |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|             
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2           2     2     2  2     2  1     2                        |             
      Artery, Necrosis, Fibrinoid          |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1     1           2                                      3         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Pars Distalis, Angiectasis           | 2        2     1  2  2           2     1     2        2  2        2  1  3|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |          2        2           2        2     2  2     2     2            |             
      Pars Distalis, Pigmentation          |                                                    1                     |             
      Pars Nervosa, Cyst, Multiple         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      C-Cell, Hyperplasia                  |                                  1                          1            |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  M|             
      Dilatation                           |                      3                                                   |             
      Hyperplasia                          |                                                          2               |             
      Inflammation, Chronic Active         |                                                          1               |             
      Necrosis                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                       X                          X      |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                   3                                                      |             
      Endometrium, Hyperplasia             |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|             
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Renal, Angiectasis                   |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2  2  2     2  2  2  2  2  2  2  2  1  1  2  2  2  2  1  2  2  2  2  2|             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2  2  2     2  2  2  3  2  2  2  2  2  3     2  2  2  2  3  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Depletion Lymphoid                   |                                                 2                        |             
      Epithelial Cell, Hyperplasia         |             2                 2                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Galactocele                          | X  X     X  X        X        X     X        X  X     X  X  X  X  X  X   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Mineralization                       |                1                                                         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                2         |             
      Edema                                |                                                       3                  |             
      Hemorrhage                           |                1                             1  1        1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|             
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                1                    1                 2  1        1      |             
      Mineralization                       |                                                       2                  |             
      Necrosis                             |                                                                          |             
      Goblet Cell, Hypertrophy             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                      +  +      |             
      Cornea, Inflammation, Chronic Active |                                                                1         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +  +      |             
      Abscess                              |                                                                3         |             
      Pigmentation                         |                                                                3         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  M|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Nephropathy                          | 2  1  1  3  2  2  3  2  2  1  2  2  1  1  2  2  3  2  3  1  2  2  2  2  2|             
      Cortex, Mineralization               |          1                       1  1                    1           1   |             
      Papilla, Mineralization              | 1        1                                                               |             
      Pelvis, Mineralization               |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8|            |
                                           | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    1.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite                             | 1  1        1                                               1  1         |      7  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoid Nodule, Hyperplasia         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoid Nodule, Hyperplasia         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       2                  |      3  1.7|
      Basophilic Focus                     | X  X  X  X  X  X  X  X        X  X     X     X  X  X  X  X  X  X  X  X  X|     43     |
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                                                                   X      |      3     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change, Diffuse                |                                     2                    2               |      4  2.0|
      Fatty Change, Focal                  |                      1     1                                         2   |      8  1.4|
      Focal Cellular Change                |                                                                         X|      3     |
      Hepatodiaphragmatic Nodule           |                         X              X                                 |      3     |
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   4        |
      Fat, Hemorrhage                      |                                                                          |      1  3.0|
      Fat, Necrosis                        |    4  3                                                                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                 +                        |   1        |
      Palate, Epithelium, Hyperplasia      |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Acanthosis                           |                                     1  1     1                       1   |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8|            |
                                           | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    1.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                         2           1  2  1  1           2               |      7  1.6|
      Necrosis                             |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1                                                      |      4  1.3|
      Mineralization                       |                                        1                                 |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2           2  2     2     2  2  2           2  2  2        2  3  2  2|     23  2.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Hyperplasia                          |                      2                                                   |      2  1.5|
      Necrosis                             |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Hyperplasia                          |                                        1        1                 1      |      7  1.4|
      Necrosis                             |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                         1                                                |      1  1.0|
      Pars Distalis, Angiectasis           | 2  2  1  2  2  3  2  1           2        1              2     1        3|     26  1.8|
      Pars Distalis, Cyst                  |    X                 X                                                   |      2     |
      Pars Distalis, Hemorrhage            |                         2                                                |      1  2.0|
      Pars Distalis, Hyperplasia           |          1           2                    2        2  1     2  2     2   |     16  1.9|
      Pars Distalis, Pigmentation          |                                  1                                       |      2  1.0|
      Pars Nervosa, Cyst, Multiple         |                                                             X            |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                2                                                         |      1  2.0|
      C-Cell, Hyperplasia                  |                               2                          1     1         |      5  1.2|
      Follicular Cell, Hyperplasia         |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  M  +  +  +  +  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8|            |
                                           | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    1.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                      2   |      2  2.0|
      Inflammation, Chronic Active         |          1                                                               |      2  1.0|
      Necrosis                             |    3                                                                 2   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                         2                                                |      2  2.5|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Congestion              | 2                                                                        |      1  2.0|
      Mediastinal, Hemorrhage              |                2                                                         |      1  2.0|
      Mediastinal, Pigmentation            | 2              2                                2                        |      3  2.0|
      Renal, Angiectasis                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Infiltration Cellular, Plasma Cell   |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                          2               |      2  2.0|
      Necrosis                             |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                           2                              |      1  2.0|
      Hematopoietic Cell Proliferation     | 2  2  2     2  2  2  2        2  2     2     2     2  2  2     2     3  1|     41  1.9|
      Necrosis                             |                                           2                              |      1  2.0|
      Pigmentation                         | 3  3  2  2     2  2  2        2  2     2        3     2  2  2           2|     38  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +|  44        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Galactocele                          | X  X  X  X     X  X     X     X     X     X  X  X  X     X     X     X  X|     32     |
      Acinus, Hyperplasia                  | 2           2                                2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8|            |
                                           | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    1.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                               2                                          |      2  2.0|
      Edema                                |                         2                                                |      2  2.5|
      Hemorrhage                           |                               1                                          |      5  1.0|
      Infiltration Cellular, Histiocyte    |                1              2                                          |      7  1.3|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                            1                                             |      1  1.0|
      Goblet Cell, Hypertrophy             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +                    +               |   5        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                                    |   3        |
      Abscess                              |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  M  +  M  M  M  +  +  +  +  M  +  M  +  +  M  +  +  +  M  M  +  +  +  +|  35        |
      Cyst                                 |                         X                                                |      1     |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                    2                     |      1  2.0|
      Nephropathy                          | 2  2  2  1  2  2  3  1  2     2  2  1  2  2  2  1  1  1  2  2  2  2  2  3|     49  1.9|
      Cortex, Mineralization               |                                                 1  1                     |      7  1.0|
      Papilla, Mineralization              |                               1                    1                     |      4  1.0|
      Pelvis, Mineralization               |                                                                         1|      1  1.0|
      Renal Tubule, Hyperplasia            |                                              1                           |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8|            |
                                           | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    1.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Pigmentation           |                               1                       1                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|             
                                           | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Parasite                             |    1           1                                2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                             2  1                                       |             
      Basophilic Focus                     |    X  X        X     X        X  X     X     X  X  X        X  X  X      |             
      Clear Cell Focus                     |       X                                                                  |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 | 1              1                                                         |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                          2               |             
      Fatty Change, Focal                  | 1     2                                                              1   |             
      Focal Cellular Change                |                         X                                                |             
      Hepatodiaphragmatic Nodule           |                X     X                       X                           |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                     2                 2                  |             
      Mixed Cell Focus                     |          X                                                     X         |             
      Necrosis                             |                            2                                             |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               | 1  2     2  2  2  2  2  1  2  1  2  2  2  3  2  3  1  2     2  2  1  2   |             
      Oval Cell, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                   +                                    |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |       1                                                                  |             
      Artery, Mineralization               |                                  2                                       |             
      Artery, Necrosis, Fibrinoid          |          2     1     3                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2                                                                 1      |             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                   2      |             
      Hyperkeratosis                       | 1                                         3                       1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|             
                                           | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Necrosis                             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Mineralization                       |                                  3                                       |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Gingiva, Inflammation, Chronic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           2  1  1        2  2  2  2  2     2  2  2  2  2     2  1  2  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Mineralization               |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1              2  1     1  2  1  2  1  1  1  2  1     1  1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M|             
      Hyperplasia                          | 1                                2                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2                    2                                2     3  2   |             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
      Pars Distalis, Hyperplasia           | 1              2  2     1     2                 2                        |             
      Pars Intermedia, Hyperplasia         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1  2                                               1         |             
      Follicular Cell, Hyperplasia         |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |       +           +                                                     +|             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Mineralization                       | 1                                                              2        1|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|             
                                           | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         | 1                                                                        |             
      Necrosis                             |    1                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic Active         |       2                             2                          2  2  2   |             
      Pigmentation                         |                                                                          |             
      Epithelium, Hyperplasia              |                   1                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2           1                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2     1     1        1     1  1     2  1  1  1  1  1  1  2  2            |             
      Seminiferous Tubule, Atrophy         | 2  2  2  1  1  1  2  2  3  2  2  1  2  2     2  2  2  2     3  2  2      |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Congestion                   | 1                                                                        |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      | 2                                                                        |             
      Mediastinal, Angiectasis             |    2                                   2                                 |             
      Mediastinal, Pigmentation            | 2                                      1                                 |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Renal, Pigmentation                  |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Erythrophagocytosis                  |                                                                          |             
      Hemorrhage                           |                                                             1            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hemorrhage                           |                                  2                                       |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Depletion Lymphoid                   |                            2                                             |             
      Fibrosis                             |                                           3                              |             
      Hematopoietic Cell Proliferation     |    1  1  1  1           2  3  1  1     1     1     2              2     2|             
      Necrosis                             |                            2                                             |             
      Pigmentation                         |                                  2                          2     2  1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  M  M  +  +  +  +  M  +  +  +  +     +  +  +|             
      Depletion Lymphoid                   |                                                                      2   |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|             
                                           | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  M  M  +  +  +  +  M  +  M  +  +  M  +  M  M  +  +  +  M  +|             
      Galactocele                          |                                           X                       X      |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                 4                        |             
      Necrosis                             |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           | 1                                2                                   3   |             
      Edema                                |                                                                      2   |             
      Embolus Tumor                        |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |             1                    1              1                        |             
      Infiltration Cellular, Histiocyte    |                                  1                                       |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation, Acute                  |    2                                                                     |             
      Inflammation, Chronic Active         |                                           2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                  +                 +   |             
      Cornea, Inflammation, Acute          | 1                                                                        |             
      Lens, Cataract                       | 2                                                                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                       X     X                           |             
      Inflammation, Granulomatous          |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Nephropathy                          | 3  3  3  3  3  3  3  3  3  1  3  4  2  2  3  3  3  2  2  2  3  3  3  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|             
                                           | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cortex, Mineralization               |                               1  2                                       |             
      Papilla, Mineralization              | 1                                                        1               |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |             1                                                            |             
      Transitional Epithelium, Hyperplasia | 1                                            1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7|            |
                                           | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Parasite                             |                               2                 1     1                  |      6  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|  46        |
      Parasite                             |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  M  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                2        1|      5  1.4|
      Basophilic Focus                     |    X  X  X     X  X     X        X        X     X  X              X     X|     25     |
      Clear Cell Focus                     |       X                                                                  |      2     |
      Congestion                           |                                                    2                     |      1  2.0|
      Degeneration, Cystic                 |    1                                                                     |      3  1.0|
      Eosinophilic Focus                   |                                                                         X|      1     |
      Fatty Change, Diffuse                |                      2                                   1               |      3  1.7|
      Fatty Change, Focal                  |                               1                 2                 1  1   |      7  1.3|
      Focal Cellular Change                |                                                             X            |      2     |
      Hepatodiaphragmatic Nodule           | X                                                                        |      4     |
      Hyperplasia, Focal                   |                         2                                                |      1  2.0|
      Hyperplasia                          |                                                                2         |      3  2.0|
      Mixed Cell Focus                     | X                             X                                          |      4     |
      Necrosis                             |                                        1                 2               |      3  1.7|
      Vacuolization Cytoplasmic            |                   2                                                      |      1  2.0|
      Bile Duct, Hyperplasia               | 1  2  2  2     2  2     2  2  2  2  2           2  2        2  2  2     1|     39  1.9|
      Oval Cell, Hyperplasia               |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +              +     +                                          |   5        |
      Fat, Mineralization                  |          1                    2                                          |      2  1.5|
      Fat, Necrosis                        |          3                    3                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                                    1                     |      1  1.0|
      Acinus, Hyperplasia                  |                                              2                 2         |      3  1.7|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Artery, Necrosis, Fibrinoid          |                                                 2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7|            |
                                           | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                     2                                    |      3  1.7|
      Edema                                |                                     2                                    |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                     1                                    |      4  1.5|
      Inflammation, Chronic Active         |                                     3                                    |      2  2.5|
      Necrosis                             |                                     2                                    |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                +                    +                                    |   2        |
      Hyperkeratosis                       |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
      Gingiva, Inflammation, Chronic       |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 2  1  1  2           2  2  1  2  2  2  2  2        2     2  2  2  2  2  1|     37  1.8|
      Inflammation, Chronic Active         |                                                                   1      |      1  1.0|
      Artery, Mineralization               |                               1                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1  1  1        1        1        2     1     1        3     2           1|     25  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  M  +  +  M  +  +  +  M  +|  40        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |       1  2                                2  1  2  2              2      |     12  1.9|
      Pars Distalis, Cyst                  |    X                                                                     |      2     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 2     2                       2                                      1   |     10  1.7|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                                                    1                     |      4  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7|            |
                                           | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |          +                    +           +                    +  +  +   |   9        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                    1                     |      4  1.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Dilatation                           |    3                                                                     |      1  3.0|
      Inflammation, Chronic Active         |    2                                                                     |      2  1.5|
      Necrosis                             |                   2        1        3  2                       2  2      |      7  1.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |    2     3                 1  3              2              1     2      |     12  2.0|
      Pigmentation                         |                                                             2            |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                      1   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Hyperplasia       |    1  2           2  2           1     1  1     1     2     1  1  1  2   |     28  1.3|
      Seminiferous Tubule, Atrophy         | 2  2  2  2     1  2     1  1  1  2     1  1  1  2  2  2  2  2  2  2  2  2|     43  1.8|
      Seminiferous Tubule, Mineralization  |                                  1                    1     1  1         |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  48        |
      Lumbar, Congestion                   |                                                                          |      1  1.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  2.0|
      Mediastinal, Angiectasis             |                                                                          |      2  2.0|
      Mediastinal, Pigmentation            |                         2                                                |      3  1.7|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                              1                           |      1  1.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +|  46        |
      Cyst                                 |          X        X           X                                          |      4     |
      Erythrophagocytosis                  |                                                    2                     |      1  2.0|
      Hemorrhage                           |                                                                   2      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A     +  +  +  +|  47        |
      Degeneration, Cystic                 |       2                                                                  |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7|            |
                                           | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Plasma Cell   |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Congestion                           |                2                                                         |      2  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 1     2        2  2     1  1     2  1  2              2     2  2  1      |     26  1.5|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |       1                                      2                           |      6  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +     M  +  +  +  +  M  M  +  +  +  A  M  +  M  +  +|  36        |
      Depletion Lymphoid                   |                                        2                       2         |      3  2.0|
      Epithelial Cell, Hyperplasia         |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  37        |
      Galactocele                          |          X           X                                                   |      4     |
      Acinus, Hyperplasia                  |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                         2                                   2        2   |      3  2.0|
      Hyperkeratosis                       |                                                             4        4  3|      4  3.8|
      Necrosis                             |                               3                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                     2                    2               |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atelectasis                          |    2                                                                     |      1  2.0|
      Congestion                           | 2                                2        3  2     2                 2  2|     10  2.1|
      Edema                                |                                     1     2                              |      3  1.7|
      Embolus Tumor                        |                                        X                                 |      1     |
      Fibrosis                             |                   2                                                      |      1  2.0|
      Hemorrhage                           |                            1                             2           1   |      6  1.2|
      Infiltration Cellular, Histiocyte    |    3              3              1                                       |      4  2.0|
      Inflammation, Acute                  |                                        3                                 |      1  3.0|
      Inflammation, Chronic Active         |                                                             1            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7|            |
                                           | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Acute                  |                                                                2         |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                    +                                             |   5        |
      Cornea, Inflammation, Acute          |                                                                          |      1  1.0|
      Lens, Cataract                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |    X     X        X                                                      |      6     |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | X     X                    X                                             |      4     |
      Nephropathy                          | 3  2  3  3     3  3  2  3  2  3  2  2  1  1  3  3  2  2  1  3  3  3  2  3|     49  2.5|
      Cortex, Mineralization               |                1                 1  1                                    |      5  1.2|
      Papilla, Mineralization              |          1                             1                                 |      4  1.0|
      Renal Tubule, Necrosis               |                               1                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                              1  1                        |      3  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Calculus Micro Observation Only      |                                                       X                  |      1     |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|             
                                           | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +  +              +              +                          M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +              +              +                          +  +|             
      Parasite                             |                            1                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +  +              +              +                          +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                    2                 1     2                 2         |             
      Basophilic Focus                     |    X  X        X        X                 X  X              X  X  X      |             
      Clear Cell Focus                     | X                                                  X        X            |             
      Degeneration, Cystic                 |          1                                                               |             
      Developmental Malformation           |    X                                                                     |             
      Eosinophilic Focus                   |                         X                                                |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |             2                                                           2|             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                         2                                                |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |    X  X                 X     X  X                 X              X      |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |             2                          2                                 |             
      Bile Duct, Hyperplasia               | 2  2           2  2  2  2  2  2        2  2  2  2  2           2  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          2                                                               |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Acinus, Hyperplasia                  |                                                             2  2         |             
      Artery, Hemorrhage                   |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                  2  1                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +     +        +              +                          +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +              +        +     +           +              +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +              +        +     +                          +  +|             
      Acanthosis                           |                                     2                                    |             
      Inflammation, Chronic                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|             
                                           | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +              +        +     +           +              +  +|             
      Erosion                              |                                     2                                    |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                       2                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +     +     +        +     +                          +  +|             
      Cardiomyopathy                       |          2  2              2        2     2                          2  2|             
      Thrombosis                           |                      X              X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +  +     +     +  +  +        +                          +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +  +     +     +  +  +        +                          +  +|             
      Hypertrophy                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +  +     +     +  +  +        +                          +  +|             
      Hyperplasia                          |          2  2                             2                          2  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        M  +              +              M                          M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +        +     +              +  +  +        +           +  +|             
      Pars Distalis, Angiectasis           |             3        2                       2  2        2               |             
      Pars Distalis, Hyperplasia           |                            2                                            2|             
      Pars Intermedia, Hyperplasia         |                                                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +              +              +                          +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +              +     +     +  +        +  +        +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +        +  +        +     +        +     +                          +  +|             
      Inflammation, Chronic Active         |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +  +        +  +  +  +           +        +              +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |          2           2  1           2  1  2              1     1  1     2|             
      Seminiferous Tubule, Atrophy         |    3  3  2        2  3  2  3  3     3  2  2  2              3  4  2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|             
                                           | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +     +  +  +  +     +  +  +  +     +                    +  +|             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Mediastinal, Angiectasis             |                                  2              2                        |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +     +        +        +  +  +     +                    +  +|             
      Angiectasis                          |                                                 2                        |             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +     +  +     +        +     +                          +  +|             
      Angiectasis                          |                            2                                             |             
      Hemorrhage                           |                            3                                             |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +|             
      Depletion Lymphoid                   |                            2                                             |             
      Fibrosis                             |                            2  3                                          |             
      Hematopoietic Cell Proliferation     |                1     2           2     2  2                       1      |             
      Hemorrhage                           |                               1                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                   3      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  M  M        +     M     +  +     +     +                    +  +|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +  M              +              +  +                       +  M|             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +  +           +              +  +  +  +              +  +  +|             
      Acanthosis                           |                2                                                  2      |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                3                                                  4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|             
                                           | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +              +              +                          +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +     +  +  +  +              +     +  +              +  +  +|             
      Atelectasis                          |                                                                         2|             
      Congestion                           | 2  2     2                 2                    2                        |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +              +              +                          +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +     +  +  +  +              +     +  +              +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +                          +        +        +                  |             
      Lens, Cataract                       |    2                                         3                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                +                 +                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Cyst                                 |                                                                          |             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 3  3  3  2  3  3  3  3  3  2  3  3  3  2  2  2  3  4  2  2  3  2  3  2  2|             
      Papilla, Mineralization              |                                                                          |             
      Renal Tubule, Hyperplasia            |    1  1                                                                  |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Transitional Epithelium, Hyperplasia |       1                       2  2              1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +              +  +           +                          +  +|             
      Calculus Gross Observation           |                               X                                          |             
      Calculus Micro Observation Only      |                               X                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6|            |
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +           +  +     +              +              M           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                                   +              +              +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                                   A              +              +|   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                                   +              +              +|  10        |
      Parasite                             |                                                                         1|      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                                   A              +              +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                                   A              +              +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                                   A              +              +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                                   A              +              A|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                                   A              +              +|   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    2        1            |      7  1.7|
      Basophilic Focus                     | X     X     X  X                       X     X              X  X  X     X|     19     |
      Clear Cell Focus                     | X                                                                        |      4     |
      Degeneration, Cystic                 |                      1  1     2        2              1                  |      6  1.3|
      Developmental Malformation           | X                                                                        |      2     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change, Diffuse                |                                                    2                     |      1  2.0|
      Fatty Change, Focal                  |                1                                         1               |      4  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Focal                   |                                     2                                    |      1  2.0|
      Hyperplasia                          |                                                       2                  |      2  2.0|
      Hyperplasia, Multifocal              |                               2                                          |      1  2.0|
      Inflammation, Granulomatous          |                                              1                           |      1  1.0|
      Mixed Cell Focus                     |             X                                                     X      |      9     |
      Necrosis                             |                                                                      2   |      1  2.0|
      Pigmentation                         |                                                                   3      |      1  3.0|
      Thrombosis                           |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               | 2  2  2  2  2     2     2     2  2  2                    2  2  2  2  2  2|     31  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                      +   |   2        |
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                                    3                     |      2  2.5|
      Acinus, Hyperplasia, Focal           |                                              1                           |      1  1.0|
      Acinus, Hyperplasia                  |                   2           2                 2              2         |      6  2.0|
      Artery, Hemorrhage                   |                                                 2                        |      1  2.0|
      Artery, Inflammation, Chronic Active |                1                                3                        |      2  2.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                             +  +  +              +              +|  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6|            |
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                       +  +  +     +  +     +     +     +        +|  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                          +        +        +     +     +        +|  14        |
      Acanthosis                           |                                  3                 2           2         |      4  2.3|
      Inflammation, Chronic                |                                                    3                     |      2  2.5|
      Ulcer                                |                                                    4                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                       +     +     A  +     +     +              +|  15        |
      Erosion                              |                               2                    2                     |      3  2.0|
      Infiltration Cellular, Lymphocyte    |                                     3        2                           |      2  2.5|
      Inflammation, Chronic                |                                                    2                     |      2  2.0|
      Necrosis                             |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                       +           +     +        +              +|  15        |
      Cardiomyopathy                       |       2                       2           2     2        2              2|     13  2.0|
      Thrombosis                           |                               2                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +           +        +              +              +           +  +|  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +           +        +              +              +           +  +|  18        |
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +           +        +              +              +           +  +|  18        |
      Hyperplasia                          |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +        +  +  +  +  +  +  +|  45        |
      Hyperplasia, Focal                   |                                                                2         |      1  2.0|
      Hyperplasia                          |                                  3                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M           +  +     +              +              M           +  M|   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +        +                       +        +  +  +           +  +|  20        |
      Pars Distalis, Angiectasis           |    2     2        2                                2  2                 1|     11  2.0|
      Pars Distalis, Hyperplasia           |       2                                                                  |      3  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +           +  +     +              +              +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +                                   +              +           +  +|  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6|            |
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +        +  +  +  +     +        M  +           +              +|  22        |
      Inflammation, Acute                  |    2                             3                                       |      2  2.5|
      Necrosis                             |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +                                   +              +              +|  13        |
      Inflammation, Chronic Active         |                                                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +                       +  +        +        +     +  +     +  +  +|  23        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |    1  2     2  2     2  2              1        1        1  2  2     2  2|     23  1.6|
      Seminiferous Tubule, Atrophy         | 2  2     3  2  2  3     3  2  3        2     4  2  2  2     2  2         |     32  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                                   +              +              +|  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +     +     +  +  +  +  +  +  +     +     +  +     +     +  +|  30        |
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                  2                                       |      1  2.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                  2                                       |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |       2                                                                  |      1  2.0|
      Mediastinal, Angiectasis             |                                                                          |      2  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |       2                                                                  |      1  2.0|
      Mediastinal, Pigmentation            |                                                 2                        |      1  2.0|
      Pancreatic, Angiectasis              |                                        2                                 |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |             2     2           2                                          |      3  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       | 3                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +                 +           +  +  +           +  +     +     +  +|  20        |
      Angiectasis                          |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                     2                                    |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                         3              3                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +           +                       +              +           +  +|  15        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +        +  +  +     +  +  +     +  +           +  +     +  +  +  +|  36        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6|            |
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     | 2     2              2        2                                2  2  2  2|     14  1.9|
      Hemorrhage                           |       2        3                       3                                 |      4  2.3|
      Mineralization                       |                1                                                         |      1  1.0|
      Necrosis                             |                2                                                         |      1  2.0|
      Pigmentation                         | 2                                                                        |      2  2.5|
      Thrombosis                           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                    +     +        +     +     +  +           +  +|  17        |
      Depletion Lymphoid                   |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +           +                       +              +              M|   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +        +                    +  +              +              +|  18        |
      Acanthosis                           |                   2                    2                                 |      4  2.0|
      Cyst Epithelial Inclusion            |                   X                    X                                 |      2     |
      Hyperkeratosis                       |                   4                    4                                 |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                                   +              +              +|  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   1        |
      Hemorrhage                           |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                 +  +     +        +     +  +  +  +  +     +  +  +|  28        |
      Atelectasis                          |                                                                          |      1  2.0|
      Congestion                           | 2                       2                 3     3                 2      |     10  2.2|
      Edema                                |                                           1                              |      1  1.0|
      Hemorrhage                           |       1                          1                                       |      2  1.0|
      Infiltration Cellular, Histiocyte    |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                                   +              +              +|  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                       +  +     +        +     +  +  +  +  +     +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                      +                 +  +|   9        |
      Lens, Cataract                       |                                                                      2   |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6|            |
                                           | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                      +                 +  +|   7        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |             X                                                            |      1     |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                         X                                                |      1     |
      Necrosis                             |                                                          2               |      1  2.0|
      Nephropathy                          | 2  2  3  3  2  3  3  3  3  2  2  3  3  3     2  3  4  3  1  3  3  2  2  1|     49  2.6|
      Papilla, Mineralization              |                                                    1                     |      1  1.0|
      Renal Tubule, Hyperplasia            | 1                                                                        |      3  1.0|
      Renal Tubule, Pigmentation           |                               3                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |          1                       1  1           1                        |      8  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                                   +              +              A|  10        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|             
                                           | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |    1           1  1              1  1  1                    1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |          1              2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        1     2     1                     |             
      Basophilic Focus                     | X  X  X  X     X     X     X     X  X     X  X     X     X  X  X         |             
      Clear Cell Focus                     | X                                            X                           |             
      Congestion                           |          1                                                               |             
      Degeneration, Cystic                 |                         1  1           1                       2        1|             
      Developmental Malformation           |                                                                          |             
      Fatty Change, Diffuse                |                                                 2                        |             
      Fatty Change, Focal                  |                                        2                                 |             
      Focal Cellular Change                |                      X        X           X                              |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                  2                                       |             
      Hyperplasia, Multifocal              |                                                                          |             
      Inflammation                         |                                                                          |             
      Mixed Cell Focus                     |    X                                                                     |             
      Necrosis                             |             2                                                            |             
      Bile Duct, Hyperplasia               | 1  1     1     2  2     2     2  1  1  2  2  2  2  2  2  2     2        1|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +  +                    +           +     +        +         |             
      Hemorrhage                           |             3                                                            |             
      Fat, Mineralization                  |                                                       1                  |             
      Fat, Necrosis                        |    2           3                    3                 3                  |             
      Fat, Pigmentation                    |                                     2                          3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                   1      |             
      Acinus, Hyperplasia                  |                                                                1         |             
      Artery, Necrosis, Fibrinoid          |                   3                                                      |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|             
                                           | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1                                                                     |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                            1           2        2                    1   |             
      Hyperplasia, Basal Cell              |                                        3                                 |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                      1   |             
      Hyperplasia                          |                                        2                       2         |             
      Infiltration Cellular, Lymphocyte    |                                     3                                    |             
      Mineralization                       |                            2                                             |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  2  2  2  1  2  2  1  2  3  2  1  1  2  2  2  2  2  2  2  2  2  2|             
      Inflammation, Acute                  |                                                       2                  |             
      Mineralization                       |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia                          |                                                                1         |             
      Vacuolization Cytoplasmic, Diffuse   |          1                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     1              1     1  2  2  1  1     1     1  2        1        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3                             2                          2         |             
      Pars Distalis, Hyperplasia           |                2     2              1     1  1  2     1     2     1  2  2|             
      Pars Intermedia, Hyperplasia         |          2     1                                               1         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1  1                    2                    1            |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                            +                                             |             
      Necrosis                             |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|             
                                           | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                2         |             
      Hyperplasia                          |                                                                3         |             
      Inflammation, Chronic Active         |       1           1                                                      |             
      Necrosis                             |                      3  3              3              3     2            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2        2                                      3                 2|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                        1                                 |             
      Necrosis                             |                                                 2                        |             
      Epithelium, Hyperplasia              |                                                                   1      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                         1  1        1  2  1  1     1  1  1           1  2|             
      Seminiferous Tubule, Atrophy         |    1  2           1  1  1     1  2  2  2  2  2  2  2     2  2  2  2  2  1|             
      Seminiferous Tubule, Mineralization  |                   1                 1                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Pigmentation                 |                                  2                                       |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Depletion Lymphoid      |                      3                                                   |             
      Mediastinal, Pigmentation            |                      2                                                   |             
      Pancreatic, Cyst                     |                X                                                         |             
      Pancreatic, Depletion Lymphoid       |                2                                                         |             
      Pancreatic, Hematocyst               |                                     X                                    |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                2         |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                   2      |             
      Renal, Pigmentation                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Degeneration, Cystic                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Degeneration, Cystic                 |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|             
                                           | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                2         |             
      Necrosis                             |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  1  1  1     2     1     1  2     3     2  1  2        3  2  2  1  2   |             
      Pigmentation                         |                   2     1  2  1              1                 2  1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Depletion Lymphoid                   |                      2                    2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  +  M  +  +  M  +  +  +  +  M  M  +  +  +  M  +  +  +  +  M|             
      Galactocele                          |       X                                X                                 |             
      Acinus, Hyperplasia                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          2                                                  2            |             
      Erosion                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |          3                                                  4            |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       2  1     1  2  2                                               2   |             
      Edema                                |             2                                                            |             
      Hemorrhage                           |                            1                                1            |             
      Infiltration Cellular, Histiocyte    | 1           1  1              1              1     1        1  1         |             
      Inflammation, Chronic Active         |                                                                      1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         1                                                |             
      Inflammation, Acute                  |          2                    2     2        2        1                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|             
                                           | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +                             +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                      +     +                  |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                            1                                             |             
      Hydronephrosis                       |       1                    4                                             |             
      Nephropathy                          | 3  3  3  3  2  2  2  3  3  2  3  3  3  3  3  3     3  3  2  3  4  3  2  3|             
      Capsule, Fibrosis                    |                                                                          |             
      Cortex, Mineralization               | 1                          2           1                       1  1      |             
      Papilla, Mineralization              | 1              1     1           1              1           1            |             
      Renal Tubule, Dilatation             |                            3                                             |             
      Renal Tubule, Necrosis               |                                                                   1      |             
      Renal Tubule, Pigmentation           |                      2                                               1   |             
      Transitional Epithelium, Hyperplasia |    1                          1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                 X                        |             
      Calculus Micro Observation Only      |                                                 X                        |             
      Fibrosis                             |                            1                                             |             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Chronic Active         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite                             | 2  2           1  1                                1        2        1   |     14  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite                             |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2                                3  2  1           1               |      8  1.6|
      Basophilic Focus                     | X  X     X     X  X           X     X                    X        X  X   |     25     |
      Clear Cell Focus                     |                                                                      X   |      3     |
      Congestion                           |                                                                          |      1  1.0|
      Degeneration, Cystic                 |          2                                                               |      6  1.3|
      Developmental Malformation           |       X                                                                  |      1     |
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                2                             1     1              1      |      5  1.4|
      Focal Cellular Change                |          X                                X  X           X        X      |      8     |
      Hemorrhage                           |       4           1                                                      |      2  2.5|
      Hyperplasia, Focal                   |       2        3              4                             3            |      5  2.8|
      Hyperplasia, Multifocal              |                                                                      2   |      1  2.0|
      Inflammation                         |                                                                      1   |      1  1.0|
      Mixed Cell Focus                     |                   X                                   X                  |      3     |
      Necrosis                             |             3                                                        1  3|      4  2.3|
      Bile Duct, Hyperplasia               | 2  1  2  2     2  2  2     2        2           2  2  2  2  3  2  2  2   |     35  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                +                                    |   9        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                                                          |      1  1.0|
      Fat, Necrosis                        |    2                                4                                    |      6  2.8|
      Fat, Pigmentation                    |    3                                                                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |                                           2                              |      1  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                                                                2         |      2  1.5|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Hyperplasia                    |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                         +|   1        |
      Palate, Epithelium, Hyperplasia      |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  48        |
      Acanthosis                           |                            2                                             |      2  1.5|
      Edema                                |       2                                                                  |      1  2.0|
      Hyperkeratosis                       |       2              2     2                                             |      7  1.7|
      Hyperplasia, Basal Cell              |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|  47        |
      Degeneration                         |                                                                          |      1  1.0|
      Hyperplasia                          |                         1                                                |      3  1.7|
      Infiltration Cellular, Lymphocyte    |                                                       2                  |      2  2.5|
      Mineralization                       |                                           1                              |      2  1.5|
      Necrosis                             |                         2                                                |      1  2.0|
      Pigmentation                         |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  2     2  2  2     2  2  2  2  2  2  2     2  2|     47  1.9|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                     1                                    |      2  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Hyperplasia                          |    1                    2  2     2  1     1     1                       2|     21  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |    2                       2           3                                 |      6  2.3|
      Pars Distalis, Hyperplasia           |       2  2  2  2     2        2           2           1  2        2      |     21  1.7|
      Pars Intermedia, Hyperplasia         |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                        1                 2               |      6  1.3|
      Follicle, Cyst                       |                                                                X         |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +        +                          +                    +  +|   6        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1                                                                        |      3  1.0|
      Necrosis                             |       1              2                                                   |      7  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       2                    2           3                          2     2|      9  2.2|
      Inflammation                         |                                     2                                    |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                        1              2        2         |      4  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |          2     1        1  1  1        2  1  1  1     1  1  2  2  1      |     25  1.2|
      Seminiferous Tubule, Atrophy         | 2  2  2  3  2  2  2  2  2  2  2  1  2  2  2  2  2  1  3  1  2  3  2  3  2|     44  1.9|
      Seminiferous Tubule, Mineralization  |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumbar, Pigmentation                 |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                     2                                    |      1  2.0|
      Mediastinal, Depletion Lymphoid      |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                     2                                    |      2  2.0|
      Pancreatic, Cyst                     |                                                                          |      1     |
      Pancreatic, Depletion Lymphoid       |                                                                          |      1  2.0|
      Pancreatic, Hematocyst               |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Hemorrhage               |                                                                         2|      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                      1   |      1  1.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Renal, Pigmentation                  |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                   X                                                      |      2     |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Degeneration, Cystic                 |    2                                                                     |      2  2.0|
      Hemorrhage                           |                                                                         2|      1  2.0|
      Infiltration Cellular, Histiocyte    |                                  2                                       |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                         2|      1  2.0|
      Depletion Lymphoid                   |             2                                   1                        |      2  1.5|
      Fibrosis                             |          2                                                           3   |      2  2.5|
      Hematopoietic Cell Proliferation     |    2  2        1           2  2     2  1        1     1        1  1      |     28  1.6|
      Pigmentation                         |                2     2     2     2     2     2     2                 1   |     15  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Depletion Lymphoid                   |                                        2                                 |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  38        |
      Galactocele                          |       X                    X        X        X                           |      6     |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                 3           3            |      4  2.5|
      Erosion                              |                   4                                                      |      1  4.0|
      Hemorrhage                           |                                                                3         |      1  3.0|
      Hyperkeratosis                       |       3                                         3           3            |      5  3.2|
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
      Necrosis                             |                   3                                            3         |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      2                                                   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |             1  2  2  2           2                                       |     11  1.7|
      Edema                                |                      2                                                   |      2  2.0|
      Hemorrhage                           |                         1           1     1  1                           |      6  1.0|
      Infiltration Cellular, Histiocyte    |       3                             1                                1   |     11  1.2|
      Inflammation, Chronic Active         |             2  2     1                 2                                 |      5  1.6|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Acute                  | 2                                               2                    2   |      8  1.9|
      Inflammation, Chronic Active         |                                                             1            |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +     +                                +                  |   6        |
      Lens, Cataract                       |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                +     +                  |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  M  M  M  M  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 X                        |      1     |
      Fibrosis                             |                                                                          |      1  1.0|
      Hydronephrosis                       |                                                                          |      2  2.5|
      Nephropathy                          | 3  2  3  3  1  3  3  1  2  3  3  3  3  3  2  2  3  3  2  2  3  2  2  2  3|     49  2.6|
      Capsule, Fibrosis                    |                                     2                                    |      1  2.0|
      Cortex, Mineralization               |             2                                1                           |      7  1.3|
      Papilla, Mineralization              |                   1        1                                            1|      9  1.0|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05023-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                    PENTAERYTHRITOL TETRANITRATE                               Date: 05/01/97  
Route: DOSED FEED                                                                                                 Time: 12:56:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    5.0%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Necrosis               |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |       2                 1                                      1         |      5  1.4|
      Transitional Epithelium, Hyperplasia |                                        1                                 |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.