National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5082

TR 371 Mouse Pathology Tables

NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108883

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|             
                                           | 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +     +     +  +  +  +  +     +  M  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             2                       1              1  2        2  2  2   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Anorectal Junction, Inflammation,    |                                                                          |             
           Acute                           |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Inflammation, Acute                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Amyloid Deposition                   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +     +  +  +  +  +     +  A  +  +     +  +  +  +  +|             
      Basophilic Focus                     |                               X                                          |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |          3  2        2     2  2  1  1                          1     1  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2        2        1           1           2     1        2  2        1|             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |          2                                                               |             
      Thrombosis                           |                                                       X                  |             
      Hepatocyte, Hypertrophy              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +           +                          +      |             
      Fat, Necrosis                        |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Infiltration Cellular, Lymphocyte    |    2     1  2                    2  2  2           2        1  1        1|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                      2        4                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Infiltration Cellular, Lymphocyte    |    1     2     2     2        2  2     2           2        2  2  2      |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|             
                                           | 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          1                                                  2        2   |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2     2              2     2              2  1              2  1|             
      Inflammation, Acute                  |                                              2                           |             
      Ulcer                                |                                                                   3      |             
      Mucosa, Dilatation                   |    1        2                       1                                   1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1  1  3                                                               |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Chronic Active         |          2                                                               |             
      Mineralization                       |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   |    2  2  2  2  2     2     2  2  2  2  2     3  2  2  2     2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                2                                                         |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |    2                                                                     |             
      Pigmentation                         |    2        2  2     2     2  2  2  2        2     2  2     2  2     2  2|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                             3            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M  +  +     +     M  +  +  M  +     +  +  M  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                             3            |             
      Pars Distalis, Hyperplasia           |       2  3  3              2                 3                          3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2                                      1                 1         |             
      Follicle, Dilatation                 |                3     2     2                 2     1  2              2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|             
                                           | 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicle, Hyperplasia                |          3     4                 1                          2  2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Abscess                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Periovarian Tissue, Cyst             |    X        X                                      X           X  X      |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    3  2  2  4  3     3     2  3  4  3  2     3     3  4     3  3  2     3|             
      Endometrium, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +                                                                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |                                                    1                     |             
      Fibrosis                             |             2  2     2           1  3        4     3        1           2|             
      Myeloid Cell, Hyperplasia            |    2     2     2     2     2  2  2  2                       2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +     +  +  +  +  +     +  M  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                               2                                          |             
      Iliac, Hyperplasia, Lymphoid         |       2                                                                  |             
      Mediastinal, Hyperplasia, Lymphoid   |       2                                                                  |             
      Mesenteric, Angiectasis              |                                                       3                  |             
      Mesenteric, Hyperplasia, Lymphoid    |    2  2     2  2              2  2           2     1        2  2  2  2   |             
      Mesenteric, Inflammation, Acute      |          3                                                               |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +     +     +  +  +  +  +     +  M  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2        2  2              2  2     1     2     3        2  3  2  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2  2  3  2  2     2        3  2  2        2     2  2     2  2     2  2|             
      Hyperplasia, Lymphoid                |    4        2                    2  2        3     3        3  3         |             
      Inflammation, Chronic                |                2                                                         |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    1        2  2     1        1  2  1        2     2  1     1  2  2  2  1|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  M  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|             
                                           | 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Ectasia                              |    2           2                             2                 2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Alopecia                             |                            2           3        2                    2   |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             
      Head, Ulcer                          |                                                                          |             
      Inguinal, Inflammation, Acute        |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
      Ventral, Inflammation, Chronic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hemorrhage                           |                                                                         1|             
      Infiltration Cellular, Lymphocyte    |                                  1                                       |             
      Mineralization                       |             2  3     2     3     2  2  2     2     2  2     2     2     2|             
      Ventricle, Dilatation                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Congestion                           |                                                             2  2        2|             
      Hemorrhage                           |       2  2                                                        2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2     2  2  2              2  2     2     2  2  2        2  2  2  2  2|             
      Mineralization                       |                      2                                                   |             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               1                                          |             
      Interstitium, Inflammation, Acute    |          1                                                               |             
      Peribronchiolar, Inflammation, Acute |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Lumen, Hemorrhage                    |    2  2  2     1           2  1  1  2        2     1        1  1     2  2|             
      Mucosa, Inflammation, Acute          |          2                                                              1|             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Olfactory Epithelium, Degeneration   |    2  2  2  2  2     2     2  2  2  2  2     2  2  2  2     2  2  2  2  2|             
      Respiratory Epithelium, Degeneration |    1  2     2                 1                    1        1            |             
      Turbinate, Inflammation, Acute       |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|             
                             DAY ON TEST   | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|             
                                           | 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2                 2  2           2  1  2     2  2  2  2   |             
      Metaplasia, Osseous                  |                      1        3                                2         |             
      Pelvis, Dilatation                   |                                        2                                 |             
      Renal Tubule, Casts Protein          |                                  1  1                                1   |             
      Renal Tubule, Dilatation             |             1  2              1  1  1        1        1        1     1  1|             
      Renal Tubule, Necrosis               |             1                                1                           |             
      Renal Tubule, Regeneration           |             1  2                 1           1                       1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +     +     +  +  +  +  +     +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2     2     1  2  2                 2  2     2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|             
                                           | 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +     +  M  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                      4                                                   |             
      Infiltration Cellular, Lymphocyte    | 2  2           1                          1                 2  1         |             
      Inflammation, Acute                  |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Anorectal Junction, Inflammation,    |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +     +  A  +     +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +     +  A  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +     +  A  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +     +  A  +     +  +  +  +  +  +  +  +   |             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +     +  A  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |                                                                          |             
      Fatty Change                         |                2                                                         |             
      Hematopoietic Cell Proliferation     | 1              2              1     1     1     2           2     1      |             
      Hyperplasia, Lymphoid                |                                           4                              |             
      Infarct                              |                2                                                         |             
      Infiltration Cellular, Lymphocyte    | 2  2     2           1              1           2  1        2  2  2      |             
      Inflammation, Acute                  |                                        1                                 |             
      Necrosis                             |          2  2  4                                                  1      |             
      Thrombosis                           |                                                                          |             
      Hepatocyte, Hypertrophy              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                           4                       4      |             
      Infiltration Cellular, Lymphocyte    |    2              2                 2           2                        |             
      Inflammation, Chronic Active         |             3                                                            |             
      Acinus, Atrophy                      |             4                                                            |             
      Duct, Cyst                           |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                   4      |             
      Infiltration Cellular, Lymphocyte    |    2     2  2  1  2     2     2     2  2  2     2  1        2            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|             
                                           | 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                             3  3         |             
      Hyperplasia, Squamous                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    1                                                                     |             
      Inflammation, Acute                  |                                                 2                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +     +  A  +     +  +  +  +  +  +  +  +   |             
      Erosion                              |          2                                                               |             
      Hyperplasia, Lymphoid                |                      4                                                   |             
      Infiltration Cellular, Lymphocyte    |    2           1                                2     2     2            |             
      Inflammation, Acute                  |                      1                                            2      |             
      Ulcer                                |                                                                          |             
      Mucosa, Dilatation                   |                                                 2     1        1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                         1              2           1  1     1     1      |             
      Inflammation, Chronic                |    1                                                                     |             
      Inflammation, Chronic Active         |                                                 2                        |             
      Mineralization                       |                                                          3               |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  M  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  3     2  2  2  2  2     2     2  2  2     2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  M  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Cyst                                 |                   X                                                      |             
      Degeneration, Fatty                  |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
      Hypertrophy                          |                                                                          |             
      Pigmentation                         | 3  2           2  2  2  2              2  2     2     2  2  2  2  2      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  M  M  +  +     +     +  +  M     M  M  +  M  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  M   |             
      Pars Distalis, Angiectasis           | 2                                                                        |             
      Pars Distalis, Hyperplasia           |                         1                 3     1        2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                      4                                                   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicle, Dilatation                 |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|             
                                           | 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicle, Hyperplasia                |                3     3                    2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                    +                     |             
      Abscess                              |                                                    4                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                           4                              |             
      Periovarian Tissue, Cyst             |                X  X     X              3                 X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  3  2  2  3  2  3  2  2     3     2  2  3     3  2  3  2  3  3  3      |             
      Endometrium, Inflammation, Acute     |                                                          3  2  2         |             
                                            __________________________________________________________________________|             
   Vagina                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Fibrosis                             | 2  2           1     2  2     3           3     4  3  4     3  3  2      |             
      Myeloid Cell, Hyperplasia            | 2  2  2  2  2     2  2  2     2     2           2  2     2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                      4                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |    2     2           4        2        3  4     2                 4      |             
      Mesenteric, Inflammation, Acute      |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |    2     1  2        4        2     2     4     2     2        2  2  2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  2  2  2           2     3     2  2  2     2  2  2      |             
      Hyperplasia, Lymphoid                |    2                                      4     3  3              4      |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                          4               |             
      Pigmentation                         | 1  2        2     1  2        2     2  2  2     2  2  2     1  2  2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +     +  M  +     +  +  +  +  +  +  +  M   |             
      Cyst                                 |             X                             X                              |             
      Hyperplasia, Lymphoid                |    2                 4                    4                       4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|             
                                           | 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Ectasia                              | 2  1           2  2  3                    2                       3      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Alopecia                             |       3                             2                    2           2   |             
      Inflammation, Acute                  |    1                                                                     |             
      Ulcer                                |                                                          2               |             
      Head, Ulcer                          |             3                                                            |             
      Inguinal, Inflammation, Acute        |                                     3                                    |             
      Subcutaneous Tissue, Hemorrhage      |          2                                                               |             
      Ventral, Inflammation, Chronic       |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                           2     1     1                  |             
      Infiltration Cellular, Lymphocyte    |    2                                   2                                 |             
      Mineralization                       | 2  2     1  2  2        2     2     2  1           2  1  2  1  2  2  2   |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Congestion                           | 2  2                          3           2                       2      |             
      Hemorrhage                           |                2     2                                                   |             
      Hyperplasia, Lymphoid                |                      4                    4                       4      |             
      Infiltration Cellular, Lymphocyte    |    2        1  2              2     2  2        2  1  2              2   |             
      Mineralization                       |                                                                          |             
      Pigmentation, Cholesterol            |                         2                                                |             
      Alveolar Epithelium, Hyperplasia     |                2        2                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         2                                                |             
      Interstitium, Inflammation, Acute    |                                                                      1   |             
      Peribronchiolar, Inflammation, Acute |          4                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Lumen, Hemorrhage                    | 2     2  3     1  2                             1     2  2  2  2  2  2   |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  3  2  2  2  2     2        1  2     2  2  2  2  2  2  2  2   |             
      Respiratory Epithelium, Degeneration |    1     2     1  1  1        1           1                    1  1      |             
      Turbinate, Inflammation, Acute       |             2                                                            |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|             
                                           | 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                      4                    4                       4      |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2     2  2  2        2     2     2  2        2  2  2              2   |             
      Metaplasia, Osseous                  |       2                                                                  |             
      Pelvis, Dilatation                   |          3                                                               |             
      Renal Tubule, Casts Protein          | 1  1           1                                                         |             
      Renal Tubule, Dilatation             | 1  1     1  1  1     1                          1     1     2  2  1      |             
      Renal Tubule, Necrosis               |             2                                      1                     |             
      Renal Tubule, Regeneration           | 1           2     1  1                             1        1  1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +     +  +  +     +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                           2                              |             
      Hyperplasia, Lymphoid                |                      4                    4                       4      |             
      Infiltration Cellular, Lymphocyte    |    2  2  2  2                 2     2  2        2  2  2              2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 0| 4| 7| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3|                                            |            |
                                           | 1| 7| 4| 7| 3| 9| 1| 3| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +  +  +  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |                         4                                                |      2  4.0|
      Infiltration Cellular, Lymphocyte    |                            2                                             |     14  1.6|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Anorectal Junction, Inflammation,    |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +                                             |  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +                                             |  49        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +                                             |  49        |
      Basophilic Focus                     |                                                                          |      1     |
      Fatty Change                         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2  1        1  1           1                                             |     23  1.4|
      Hyperplasia, Lymphoid                |                4                                                         |      2  4.0|
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |             2        1  2  2                                             |     23  1.7|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Necrosis                             | 3           2                                                            |      7  2.3|
      Thrombosis                           |                                                                          |      1     |
      Hepatocyte, Hypertrophy              | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   5        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                4                                                         |      4  3.5|
      Infiltration Cellular, Lymphocyte    | 1  2              1                                                      |     17  1.6|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      3  3.3|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                4        4                                                |      4  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 0| 4| 7| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3|                                            |            |
                                           | 1| 7| 4| 7| 3| 9| 1| 3| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    | 1  2        2              2                                             |     28  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Erosion                              |                         2                                                |      1  2.0|
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Focal, Squamous         |                                                                          |      2  3.0|
      Hyperplasia, Squamous                |                         2  2                                             |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                            2                                             |      5  1.6|
      Inflammation, Acute                  |                            2                                             |      2  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +                                             |  49        |
      Erosion                              | 3                                                                        |      2  2.5|
      Hyperplasia, Lymphoid                |                4                                                         |      2  4.0|
      Infiltration Cellular, Lymphocyte    | 2                          2                                             |     15  1.8|
      Inflammation, Acute                  |                3                                                         |      4  2.0|
      Ulcer                                | 3                                                                        |      2  3.0|
      Mucosa, Dilatation                   |             1     2        1                                             |     10  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +     +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |             1                                                            |     10  1.3|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Valve, Thrombosis                    |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +                                             |  49        |
      Capsule, Spindle Cell, Hyperplasia   | 3  2  2     2  3  2  2  2  2                                             |     49  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +                                             |  49        |
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Pigmentation                         | 2           2  2  2     2  2                                             |     35  2.0|
      Thrombosis                           |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 0| 4| 7| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3|                                            |            |
                                           | 1| 7| 4| 7| 3| 9| 1| 3| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M     M  +  +  M  +  M                                             |  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +                                             |  49        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           | 3                 3                                                      |     12  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                1                                                         |      5  1.4|
      Follicle, Dilatation                 |                                                                          |      8  2.0|
      Follicle, Hyperplasia                |                            1                                             |      9  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                4                                                         |      2  4.0|
      Periovarian Tissue, Cyst             |                         X                                                |     11  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                   3                                                      |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  3        3  3  3     3  3                                             |     45  2.7|
      Endometrium, Inflammation, Acute     |                            1                                             |      4  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Fibrosis                             |                1  2     3                                                |     25  2.4|
      Myeloid Cell, Hyperplasia            |    2           2        2                                                |     33  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  M     +  +  +  +  +  +                                             |  48        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                4           2                                             |      3  2.7|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 0| 4| 7| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3|                                            |            |
                                           | 1| 7| 4| 7| 3| 9| 1| 3| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric, Angiectasis              |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    | 2  3        2  4        2  2                                             |     26  2.3|
      Mesenteric, Inflammation, Acute      |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                4                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M     +  +  M  +  +  +                                             |  47        |
      Hyperplasia, Lymphoid                | 2  2        2  4     2  2  2                                             |     31  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     | 2  2        2  2  2  3  2  2                                             |     41  2.1|
      Hyperplasia, Lymphoid                |             2  4        4                                                |     16  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation                         | 2           1  2  2     2  2                                             |     37  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +     +  +  +  +  +  +                                             |  46        |
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Lymphoid                |                4     2                                                   |      7  3.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  +  +                                             |  49        |
      Ectasia                              | 2           4  2        2                                                |     16  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Alopecia                             | 2                                                                        |      9  2.2|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
      Head, Ulcer                          |                                                                          |      1  3.0|
      Inguinal, Inflammation, Acute        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  2.0|
      Ventral, Inflammation, Chronic       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                2                                                         |      5  1.4|
      Infiltration Cellular, Lymphocyte    |                            2                                             |      4  1.8|
      Mineralization                       |    2        2     2  2  2  1                                             |     35  1.9|
      Ventricle, Dilatation                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 0| 4| 7| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3|                                            |            |
                                           | 1| 7| 4| 7| 3| 9| 1| 3| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Congestion                           |    2        2        3  1  2                                             |     13  2.1|
      Hemorrhage                           |                                                                          |      5  2.0|
      Hyperplasia, Lymphoid                |                4        4                                                |      5  4.0|
      Infiltration Cellular, Lymphocyte    | 2  2        2        2     2                                             |     30  1.9|
      Mineralization                       |             2                                                            |      2  2.0|
      Pigmentation, Cholesterol            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  1.5|
      Interstitium, Inflammation, Acute    |                1                                                         |      3  1.0|
      Peribronchiolar, Inflammation, Acute |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |    2        2     3  2  1                                                |     31  1.8|
      Mucosa, Inflammation, Acute          |                            1                                             |      3  1.3|
      Nasolacrimal Duct, Hemorrhage        |                1                                                         |      1  1.0|
      Olfactory Epithelium, Degeneration   | 2  3        2  2  2  2  2  2                                             |     48  2.0|
      Respiratory Epithelium, Degeneration |             1  1           1                                             |     18  1.2|
      Turbinate, Inflammation, Acute       |                                                                          |      1  2.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Acute                           | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                4        4                                                |      6  3.7|
      Infarct                              |                      3                                                   |      1  3.0|
      Infiltration Cellular, Lymphocyte    | 2  2        2        2     1                                             |     31  1.9|
      Metaplasia, Osseous                  |                                                                          |      4  2.0|
      Pelvis, Dilatation                   |                                                                          |      2  2.5|
      Renal Tubule, Casts Protein          |                                                                          |      6  1.0|
      Renal Tubule, Dilatation             |             2  1  1                                                      |     24  1.2|
      Renal Tubule, Necrosis               |             1                                                            |      5  1.2|
      Renal Tubule, Regeneration           |             2              2                                             |     14  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 0| 4| 7| 7| 7| 3| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3|                                            |            |
                                           | 1| 7| 4| 7| 3| 9| 1| 3| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                4                                                         |      5  3.6|
      Infiltration Cellular, Lymphocyte    | 2  2        2        2     2                                             |     31  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|             
                                           | 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                           3                              |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    | 2              2  2     2                                         1  2   |             
      Inflammation, Acute                  |                                                          3               |             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Anorectal Junction, Inflammation,    |                                                                          |             
           Chronic Active                  |                         2                                                |             
      Anus, Inflammation, Acute            |                                                       4                  |             
      Anus, Ulcer                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                       4                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                4         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  1  1        1  2     1           2  2  2              3  2  2     2   |             
      Infiltration Cellular, Lymphocyte    | 2  2           2  2     2     2  2        2                 2            |             
      Necrosis                             |                                     2                                    |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                3         |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +           +                              |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    | 2  2     1     2  2           2  2  2     2                    2  2  1   |             
      Inflammation, Acute                  |                                                          3               |             
      Acinus, Atrophy                      |                                  3     4                                 |             
      Duct, Cyst                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    | 2  2     2  1  2  2     1     2     2  2  2                       3  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Erosion                              |                                                                      2   |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|             
                                           | 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Squamous                |                                                                      3   |             
      Infiltration Cellular, Lymphocyte    |                                     2                                2   |             
      Inflammation, Acute                  |                2                                                  2      |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Ulcer                                |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Edema                                |                                                                          |             
      Erosion                              |                            3                                             |             
      Infiltration Cellular, Lymphocyte    | 2  1           2              2  1  2  2  2                    2  1  2   |             
      Inflammation, Acute                  |                2              2                                          |             
      Inflammation, Chronic                |    2                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                     1                                    |             
      Ulcer                                |             3                                         3                  |             
      Mucosa, Dilatation                   |    2           2  1              2  1     1              2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    | 1              1  1     1     1        1  1           1        1  1  1   |             
      Inflammation, Acute                  |                                                          4               |             
      Inflammation, Chronic                |                                                             2            |             
      Atrium, Thrombosis                   |                                              4                           |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Capsule, Inflammation, Acute         |                                                          2               |             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2  2  2  3  2     2  2  3  2  2  2  2  2        2  2  3  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Degeneration, Fatty                  |                                                                          |             
      Hypertrophy                          |                         2                                                |             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 2  2  2     2  2  2     2  2  2  2  2  2  2  2        1  2  2     2  2   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        M  +  +  +  +  +   |             
      Hyperplasia                          |                                                                      2   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  M  M  M     M  +  M  M  M  M  M  +        M  M  +  M  M  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|             
                                           | 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                         2                                                |             
      Pars Distalis, Hemorrhage            |                   4                                                      |             
      Pars Distalis, Hyperplasia           |          2              2  2        3  3  3           3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    | 2                             2     1                 2                  |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 |                   2                                                      |             
      Follicle, Hyperplasia                |                               3                       2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +                                                                  |             
      Cyst                                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Abscess                              |                                                          4               |             
      Hemorrhage                           |                            3                                             |             
      Infiltration Cellular, Lymphocyte    |                3                                                         |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation, Hemosiderin,           |                                                                          |             
          Cholesterol                      |                                                                      3   |             
      Follicle, Cyst                       |                               X                                          |             
      Follicle, Cyst Multilocular          |       X                                                                  |             
      Periovarian Tissue, Cyst             |                         X                                   X     X      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Endometrium, Hyperplasia, Cystic     | 2  2  2  2  3  2  2     4  3        3  3              2  2        3  3   |             
      Endometrium, Inflammation, Acute     |                         2  2        4                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                             +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Fibrosis                             | 2  2           2  2     2     2        2  1  2                    2  1   |             
      Myeloid Cell, Hyperplasia            | 2  2           2  2     2  2  2  2  2  2  2  2        2     2  2     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Bronchial, Hyperplasia, Lymphoid     |                                                             2            |             
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |             
      Mediastinal, Inflammation, Acute     |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|             
                                           | 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Congestion               |          2                                   3              3        4   |             
      Mesenteric, Hyperplasia, Lymphoid    | 2  2  2        2  2     2                             2     2  2         |             
      Mesenteric, Inflammation, Acute      |                2                    2                    3        2      |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Hyperplasia, Glandular               |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2     2     2  2     2     2     2  2              2     2  2  2      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                     2                    3               |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     | 2  2  2  2     2  2     2  3  2  2  3  2  2  2        2  4  3     2  2   |             
      Hyperplasia, Lymphoid                | 2  2           2                                                  2  2   |             
      Infiltration Cellular                |                                                                2         |             
      Pigmentation                         | 2  2              2     2     2  2  2  1  2  2        2           1  2   |             
      Capsule, Inflammation, Acute         |                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Ectopic Thyroid                      |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |       3        2  2              2                       3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +     +  +  +  +  +  +  +  +        M  +  +  +  +  +   |             
      Ectasia                              | 2                          2  1  2        4                    2         |             
      Acinus, Ectasia                      |                                              3                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Alopecia                             |          2                                               3  2            |             
      Inflammation, Chronic                |                                                                          |             
      Foot, Ulcer                          |                                                       4                  |             
      Head, Ulcer                          |                                                                          |             
      Inguinal, Ulcer                      |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Femur, Fracture                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Head, Inflammation, Acute            |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|             
                                           | 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Compression                          |                                              3                 2         |             
      Hemorrhage                           |                                     2     1                              |             
      Infiltration Cellular, Lymphocyte    |                                  2                                2  1   |             
      Mineralization                       | 2              2  2     2  2  2  2  1  2  2           3     1            |             
      Nerve, Inflammation, Acute           |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Congestion                           |    2                                2  2                             2   |             
      Hemorrhage                           |                                     1        2                    3      |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2     2  2     2     2  2  2  1     2        2  2  2  2  2  2   |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                           3  2                           |             
      Interstitium, Inflammation, Acute    |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Peribronchiolar, Inflammation, Acute |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                          |             
      Pleura, Interstitium, Inflammation,  |                                                                          |             
           Acute                           |                                                          2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Lumen, Hemorrhage                    | 1  2     2  2           2  2  2  1  2  2                 2  3  2  2  2   |             
      Mucosa, Inflammation, Acute          | 2                          2                                   3         |             
      Nasolacrimal Duct, Hemorrhage        |                2                                                         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |    3        2                                                            |             
      Olfactory Epithelium, Degeneration   | 2  2        2     2     2  2  2  2  2  2  1  2        1     1  3  2  1   |             
      Respiratory Epithelium, Degeneration |          1  2                          1  1  2                 3         |             
      Turbinate, Inflammation, Acute       |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Abscess                              |                                                                4         |             
      Hemorrhage                           |                                     2                                    |             
      Infiltration Cellular, Lymphocyte    | 2  2     2  2  3  2        2  2  2  2                 2     2  2  2  2   |             
      Inflammation, Chronic                |                                              4                           |             
      Inflammation                         |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|             
                                           | 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Metaplasia, Osseous                  | 3                                                                        |             
      Capsule, Inflammation, Chronic       |                                                                3         |             
      Pelvis, Dilatation                   | 2                                                                        |             
      Pelvis, Inflammation, Acute          |                                                                2         |             
      Renal Tubule, Casts Protein          |                2                                                         |             
      Renal Tubule, Dilatation             | 2  2     1     2  1     1     1  1  1  2  2           2           1  1   |             
      Renal Tubule, Necrosis               | 1              1                                            2            |             
      Renal Tubule, Pigmentation           |                                                             2            |             
      Renal Tubule, Regeneration           | 2     2  1     2  1              1  2     1                 2        1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                          +               |             
      Dilatation                           |                                                          1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +  +   |             
      Ectasia                              | 2                                                                        |             
      Infiltration Cellular, Lymphocyte    |    2  1  2     3  2        2     2  3     2  2           2  2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|             
                             DAY ON TEST   | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|             
                                           | 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    |       2     2  2        2        2           2                 1         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Anorectal Junction, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                          |             
      Anus, Inflammation, Acute            |                                                                          |             
      Anus, Ulcer                          |                            4                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Amyloid Deposition                   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Fatty Change                         |                                                             2            |             
      Hematopoietic Cell Proliferation     |       2     2     2  1  2  1  2  2  3     2  1  2                    1   |             
      Infiltration Cellular, Lymphocyte    |                1                 2                 2           1         |             
      Necrosis                             | 4                             2     3                                    |             
      Vacuolization Cytoplasmic            |                                                             2            |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Inflammation, Chronic                |                      4                                                   |             
      Fat, Necrosis                        |                      4                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    |             1  1                 2        2  2     2           2     2   |             
      Inflammation, Acute                  |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    | 2              1     2  1  2  1  2  2     1  2     2           2     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Hyperplasia, Focal, Squamous         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Erosion                              |                                  1                                       |             
      Hyperplasia, Focal, Squamous         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|             
                             DAY ON TEST   | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|             
                                           | 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Squamous                |             3  3                                                         |             
      Infiltration Cellular, Lymphocyte    |       2        2                          2  1     2           2         |             
      Inflammation, Acute                  |    3                    2                                      1         |             
      Inflammation, Chronic Active         |             2                                                            |             
      Ulcer                                |                3     4                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Edema                                |                2                                                         |             
      Erosion                              |                            2        1                 2                  |             
      Infiltration Cellular, Lymphocyte    |       2     2  2                          2        2           2     1   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                            2                                             |             
      Ulcer                                |                                                                          |             
      Mucosa, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    |                      1  2                    1     1           2         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                               2  2        2                              |             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Capsule, Inflammation, Acute         |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |    2  2     3  2  2  2  2  2  2  2  2     2  2  2  3  2     2  2     2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Degeneration, Fatty                  |       2     2                                                            |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                      4                                                   |             
      Pigmentation                         |    2  2     2  3  2  2  2  2  2  2  2     2  2  2  2  2     2  2     2   |             
      Thrombosis                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                      4                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M     +  +  M  +  +  M  M  M  +     +  +  +  M  M     +  M     M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Pars Distalis, Angiectasis           |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|             
                             DAY ON TEST   | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|             
                                           | 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |       X                                                                  |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |       3        2                                   2                 2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Infiltration Cellular, Lymphocyte    |             3  2           2     1                                       |             
      Inflammation, Acute                  |                                  1                                       |             
      Inflammation, Chronic                |                                                                      2   |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 |                               2  2                                       |             
      Follicle, Hyperplasia                |       1     4        2           2           1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Abscess                              |                         4                                                |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                  4                                       |             
      Pigmentation, Hemosiderin,           |                                                                          |             
          Cholesterol                      |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Cyst Multilocular          |                                                                          |             
      Periovarian Tissue, Cyst             |                X  X        2     X                                   X   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Endometrium, Hyperplasia, Cystic     |       3     1     2  2  2  2  2  2        1  3     3  2        2     3   |             
      Endometrium, Inflammation, Acute     |                            2                                3            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Fibrosis                             |       2     1  1           2     1           2     2           1     3   |             
      Myeloid Cell, Hyperplasia            |    2  2     2  2  2  2  2  2  2  2        2  2  2  2                 2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                     2                                    |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|             
                             DAY ON TEST   | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|             
                                           | 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Congestion               |                                           3                    2         |             
      Mesenteric, Hyperplasia, Lymphoid    |                         2     2  2        2  3              2  2     3   |             
      Mesenteric, Inflammation, Acute      |             3  3     4                                                   |             
      Renal, Congestion                    |                                     3                                    |             
      Renal, Hyperplasia, Lymphoid         |                                     3                                    |             
      Renal, Inflammation, Acute           |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Hyperplasia, Glandular               |                                     2                                    |             
      Hyperplasia, Lymphoid                | 2     2     2  2     2  2     2  2        2  3     2  2        2     3   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | A  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Hematopoietic Cell Proliferation     |    2  1     2  2  2  2  2     3  3  2     2  2     2           2     2   |             
      Hyperplasia, Lymphoid                |             1                    2           2                 2     2   |             
      Infiltration Cellular                |                                                                          |             
      Pigmentation                         |    2  2     2  2     2        2  2  2     2  2     2        1  2     2   |             
      Capsule, Inflammation, Acute         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Cyst                                 |                X                                                         |             
      Ectopic Thyroid                      |                                                                X         |             
      Edema                                |                      3                                                   |             
      Hyperplasia, Lymphoid                |                2                             3                       2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Ectasia                              |                3        2  3  2              1  2              3         |             
      Acinus, Ectasia                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Alopecia                             |                   3                             1     2              3   |             
      Inflammation, Chronic                |                2                                                         |             
      Foot, Ulcer                          |                                                                          |             
      Head, Ulcer                          |                                                                          |             
      Inguinal, Ulcer                      |    4                                                                     |             
      Subcutaneous Tissue, Edema           |                                           2                              |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Femur, Fracture                      |                         X                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Head, Inflammation, Acute            |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|             
                             DAY ON TEST   | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|             
                                           | 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Compression                          |                                                                X         |             
      Hemorrhage                           |       1                                                                  |             
      Infiltration Cellular, Lymphocyte    |                                  1                                       |             
      Mineralization                       |    2  3     2  2  1  2  2  2  1  2  2                 2        2     2   |             
      Nerve, Inflammation, Acute           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Congestion                           |                            3        2                          2         |             
      Hemorrhage                           |                               2                 2              2         |             
      Infiltration Cellular, Lymphocyte    | 2  2  2     2  2     2  2     2  2  2     2  2     2        2  2     2   |             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Interstitium, Inflammation, Acute    |    2                                                                     |             
      Interstitium, Inflammation, Chronic  |                1                                                         |             
      Peribronchiolar, Inflammation, Acute |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                2         |             
      Pleura, Interstitium, Inflammation,  |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Lumen, Hemorrhage                    |       2     1  2     3  2                       3  3           2     2   |             
      Mucosa, Inflammation, Acute          |                            1                                             |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   |    2  1     1  1  2  2  2     2  2  2     2  2  2  2        1        2   |             
      Respiratory Epithelium, Degeneration |    2                    1     2                 1           1  2         |             
      Turbinate, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Abscess                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2     2  2     2  2     2  2        2  2     2  2     2  2     2   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|             
                             DAY ON TEST   | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|             
                                           | 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Acute          |                                     3                                    |             
      Renal Tubule, Casts Protein          |             1                 2                             2            |             
      Renal Tubule, Dilatation             |       1     2  1     2        3           2  1  2  1        2  1     2   |             
      Renal Tubule, Necrosis               |       1              2        2           1                              |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |       1        2              2  2        1        1           1     1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +   |             
      Ectasia                              |                                     2                                    |             
      Infiltration Cellular, Lymphocyte    |       2     2  2  2     2  2     2        2  2     2           2     2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 4| 7| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6|                                            |            |
                                           | 1| 3| 0| 3| 7| 9| 2| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |    2                    2                                                |     15  1.9|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Anorectal Junction, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Anus, Inflammation, Acute            |                                                                          |      1  4.0|
      Anus, Ulcer                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Amyloid Deposition                   |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Fatty Change                         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    1     2     2        2                                                |     30  1.8|
      Infiltration Cellular, Lymphocyte    |       2                    2                                             |     15  1.9|
      Necrosis                             |                                                                          |      4  2.8|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |    2  2           2     2  2                                             |     25  1.8|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      2  3.5|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    | 1     2  2     2  1     2  2                                             |     33  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 4| 7| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6|                                            |            |
                                           | 1| 3| 0| 3| 7| 9| 2| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Erosion                              |                                                                          |      2  1.5|
      Hyperplasia, Focal, Squamous         |                         4                                                |      2  3.0|
      Hyperplasia, Squamous                |                         2                                                |      4  2.8|
      Infiltration Cellular, Lymphocyte    |                                                                          |      8  1.9|
      Inflammation, Acute                  |                            2                                             |      6  2.0|
      Inflammation, Chronic Active         |                2                                                         |      3  2.0|
      Ulcer                                |                         2                                                |      4  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +                                             |  50        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      4  2.0|
      Infiltration Cellular, Lymphocyte    | 2                 2  1     2                                             |     22  1.8|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Mineralization                       |                                                                          |      2  1.5|
      Ulcer                                |                                                                          |      2  3.0|
      Mucosa, Dilatation                   | 2                 1     2                                                |     10  1.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +     +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |    1     1        2     1                                                |     20  1.2|
      Inflammation, Acute                  |       2        1                                                         |      3  2.3|
      Inflammation, Chronic                |                                                                          |      4  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +                                             |  50        |
      Capsule, Inflammation, Acute         |                                                                          |      1  2.0|
      Capsule, Spindle Cell, Hyperplasia   | 3  2  2  2     2  2  2  2  2                                             |     49  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Degeneration, Fatty                  |                                                                          |      2  2.0|
      Hypertrophy                          |                2                                                         |      2  2.0|
      Necrosis                             |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 4| 7| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6|                                            |            |
                                           | 1| 3| 0| 3| 7| 9| 2| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |    2  2  2     2  2     2  2                                             |     45  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M     M  M  M  M  +                                             |  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +                                             |  49        |
      Pars Distalis, Angiectasis           | 2                                                                        |      2  2.5|
      Pars Distalis, Cyst                  |                            X                                             |      3  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |       2           3        2                                             |     14  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      8  1.9|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                   1                                                      |      1  1.0|
      Follicle, Dilatation                 |                   2                                                      |      4  2.0|
      Follicle, Hyperplasia                |                                                                          |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      2  4.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Acute                  |                4                                                         |      2  4.0|
      Pigmentation, Hemosiderin,           |                                                                          |            |
          Cholesterol                      |                                                                          |      1  3.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicle, Cyst Multilocular          |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                                                                          |      8  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                            +                                             |   1        |
      Inflammation, Acute                  |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 4| 7| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6|                                            |            |
                                           | 1| 3| 0| 3| 7| 9| 2| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Endometrium, Hyperplasia, Cystic     | 3  4  3  3     2  3  2  3  2                                             |     38  2.4|
      Endometrium, Inflammation, Acute     |                   3        1                                             |      7  2.4|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +                                             |  50        |
      Fibrosis                             |    1     3     2  2     2  3                                             |     26  1.8|
      Myeloid Cell, Hyperplasia            | 2  2     2     2  2     2  2                                             |     38  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                         3                                                |      2  2.5|
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.0|
      Mediastinal, Inflammation, Acute     |                                                                          |      1  3.0|
      Mesenteric, Congestion               |                                                                          |      6  2.8|
      Mesenteric, Hyperplasia, Lymphoid    |       2        2        2  2                                             |     21  2.1|
      Mesenteric, Inflammation, Acute      |                                                                          |      7  2.7|
      Renal, Congestion                    |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Inflammation, Acute           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Hyperplasia, Glandular               |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |    2  2  2     3        2                                                |     32  2.1|
      Hyperplasia                          |                            3                                             |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +                                             |  49        |
      Hematopoietic Cell Proliferation     | 3  2     2     3  2  2  2                                                |     41  2.2|
      Hyperplasia, Lymphoid                |    2           2        1                                                |     13  1.8|
      Infiltration Cellular                |                                                                          |      1  2.0|
      Pigmentation                         |    2  2  2     1     2  2  2                                             |     34  1.9|
      Capsule, Inflammation, Acute         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  M  M  +  +                                             |  48        |
      Cyst                                 |                                                                          |      1     |
      Ectopic Thyroid                      |                                                                          |      1     |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    2           3                                                         |     10  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 4| 7| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6|                                            |            |
                                           | 1| 3| 0| 3| 7| 9| 2| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +  +                                             |  48        |
      Ectasia                              | 2  2  2  2        1                                                      |     18  2.1|
      Acinus, Ectasia                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Alopecia                             |                            2                                             |      8  2.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Foot, Ulcer                          |                                                                          |      1  4.0|
      Head, Ulcer                          |       3                                                                  |      1  3.0|
      Inguinal, Ulcer                      |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Femur, Fracture                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Head, Inflammation, Acute            |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +                                             |  50        |
      Compression                          |                                                                          |      3  2.5|
      Hemorrhage                           | 2                                                                        |      4  1.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      4  1.5|
      Mineralization                       | 2  3  2           2                                                      |     30  2.0|
      Nerve, Inflammation, Acute           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Congestion                           |       3  2                                                               |      9  2.2|
      Hemorrhage                           | 2                                                                        |      7  2.0|
      Infiltration Cellular, Lymphocyte    |    2  2        2  2     2  2                                             |     40  2.0|
      Alveolar Epithelium, Hyperplasia     |          2                                                               |      3  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                2                                                         |      3  2.3|
      Interstitium, Inflammation, Acute    |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  1.0|
      Peribronchiolar, Inflammation, Acute |                      4                                                   |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 4| 7| 7| 6| 7| 6|                                            |            |
                             DAY ON TEST   | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6|                                            |            |
                                           | 1| 3| 0| 3| 7| 9| 2| 3| 9| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Pleura, Inflammation, Chronic        |                                                                          |      1  2.0|
      Pleura, Interstitium, Inflammation,  |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |          3        3  2     2                                             |     28  2.1|
      Mucosa, Inflammation, Acute          |                                                                          |      4  2.0|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |       2  2     3                                                         |      5  2.4|
      Olfactory Epithelium, Degeneration   | 2  1  2  2        2  2  2  2                                             |     41  1.8|
      Respiratory Epithelium, Degeneration | 1                          2                                             |     14  1.6|
      Turbinate, Inflammation, Acute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2  2  2        2        2  2                                             |     36  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  4.0|
      Metaplasia, Osseous                  | 2                    2                                                   |      3  2.3|
      Capsule, Inflammation, Chronic       |                                                                          |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      2  2.5|
      Renal Tubule, Casts Protein          |                         2                                                |      5  1.8|
      Renal Tubule, Dilatation             |    1           1  1     2                                                |     30  1.5|
      Renal Tubule, Necrosis               |                         2  1                                             |      9  1.4|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |    1           1  1     2  2                                             |     23  1.4|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +                                             |  50        |
      Ectasia                              |                                                                          |      2  2.0|
      Infiltration Cellular, Lymphocyte    |    2  2  2     2  2     2  2                                             |     34  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|             
                                           | 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1              2  3  2           1  1           2                  |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Anorectal Junction, Ulcer            |                                                                          |             
      Anus, Erosion                        |                                              2                           |             
      Anus, Inflammation, Acute            |                                                                          |             
      Anus, Inflammation, Chronic Active   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Bile Stasis                          |                               2                                          |             
      Congestion                           |                                                                          |             
      Fatty Change                         |                                                          2               |             
      Hematopoietic Cell Proliferation     |          1              2              2  2  2  3        1     2  2  2  1|             
      Infiltration Cellular, Lymphocyte    |          2           2  2  2           1  2  2        2  2              2|             
      Inflammation, Acute                  |                            1                                             |             
      Inflammation, Chronic Active         |                               3                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                 3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1  2           2  2  2           2  2  2  1     2  1     2        2|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2           2  2     2        2  2  2        2  2     2        2|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Angiectasis                          |                3                                                         |             
      Erosion                              |                                              2                           |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|             
                                           | 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Squamous                |       2                                      2                           |             
      Infiltration Cellular, Lymphocyte    |                                                                      1   |             
      Inflammation, Acute                  |                      3  1              1     3                 2         |             
      Inflammation, Chronic                |                               3                                          |             
      Inflammation, Chronic Active         |       2        3                                                         |             
      Ulcer                                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Erosion                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       1  2     2  1  1  2  2                                   1     2  2|             
      Inflammation, Acute                  |                                           2                       1      |             
      Mineralization                       |                                                                          |             
      Mucosa, Dilatation                   |                      1     1           2  2  2        2                 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1  2              1  1                    1              1     1   |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   |    3  3  2     3  2  2  2  2  2        2  2  3  2     2  2        2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy, Diffuse                 |                                                                         2|             
      Hypertrophy                          |                                              2                           |             
      Pigmentation                         |    2  2  2     2     2  2  1  2        2  2  2        2  2     2  2  2  2|             
      Spindle Cell, Hyperplasia            |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  M  M     M  +  +  M  M  M        M  M  M  +     M  +     M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +     +  M  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Pars Distalis, Hyperplasia           |          3              2                    2  2     2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                   1              1|             
      Inflammation, Acute                  |                2                                                         |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Follicle, Dilatation                 |                2                          2                              |             
      Follicle, Hyperplasia                |                                              2           1           2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|             
                                           | 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Hemorrhage                           |                         4              4                                 |             
      Hyperplasia, Adenomatous             |                                                          3               |             
      Inflammation, Acute                  |                                        4     4                           |             
      Mineralization                       |                                                 2                        |             
      Periovarian Tissue, Cyst             |                      4                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Endometrium, Hyperplasia, Cystic     |       3  2        2  3  4  2           2  2  2        3  2     2  2  2  1|             
      Endometrium, Inflammation, Acute     |                            2           3                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Fibrosis                             |       4              2  2  1           3  2           2              2   |             
      Fibrous Osteodystrophy               |                                                                         1|             
      Myeloid Cell, Hyperplasia            |    2  2        2  2  2  2  2  2        2  2  2  3     2        2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Mediastinal, Congestion              |                   2                                                      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                 2                        |             
      Mesenteric, Angiectasis              |                2                                                         |             
      Mesenteric, Congestion               |                         2                                2               |             
      Mesenteric, Hemorrhage               |                               4                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                      2  3  2  2              2           2        2      |             
      Mesenteric, Inflammation, Acute      |                2                       3  2     3     3                  |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |          3     2  2  2  3  2  2           2  2           2        2      |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  2  2     2  1  2  3  2  3        3  2  3  3     2  2     2  4  2  2|             
      Hyperplasia, Lymphoid                |                      2     2           2              2                  |             
      Pigmentation                         |    1  2           2  1     2  2        2  1  2        2  1               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |    2                                      2                              |             
      Hyperplasia, Lymphoid                |       2  2                 3              2              2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|             
                                           | 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +     +  +  +  +  +  +        +  M  +  +     +  +     +  +  +  +|             
      Ectasia                              |                      1  2  1                                   3     3  3|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Alopecia                             |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Cranium, Fracture                    |                                                                          |             
      Cranium, Inflammation, Chronic Active|                                                                          |             
      Femur, Fracture                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Compression                          |                                                          3               |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                         2|             
      Mineralization                       |                            2  2        2  2  2  2     2        2  2  2  2|             
      Hippocampus, Cyst                    |                                                                      X   |             
      Meninges, Inflammation, Acute        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Congestion                           |                2              3                       2                 2|             
      Hemorrhage                           |          2                                1                              |             
      Infiltration Cellular, Lymphocyte    |       2  2     2  2  2  2  2  2        2  2  2  2     2  2        2  2   |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   3                                            1  4      |             
      Interstitium, Inflammation, Acute    |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Lumen, Hemorrhage                    |    4     2        2  1  2     2        2  1  2                       2   |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                2                                               3         |             
      Olfactory Epithelium, Degeneration   |    2     2     2  2  2     2  2           2  1  2        2     1  2  2   |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Acute                           |                                                                      2   |             
      Olfactory Epithelium, Metaplasia     |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|             
                                           | 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Degeneration |    2                    2              1                          2      |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Hemorrhage                           |          3                                                               |             
      Glands, Inflammation, Acute          |                                                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                    +                                +         |             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Acute                  |                               4                                          |             
      Inflammation, Chronic Active         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Infarct                              |                                                 4                        |             
      Infiltration Cellular, Lymphocyte    |    2  2  2     2  2  3  2  2  2        2  2  2  2     2  2        2      |             
      Inflammation, Acute                  |                                                                          |             
      Metaplasia, Osseous                  |       2  2                                                               |             
      Regeneration                         |                                                                          |             
      Renal Tubule, Casts Protein          |                1           1                                            1|             
      Renal Tubule, Dilatation             |    2           1           1  1        1  2  2                       1  1|             
      Renal Tubule, Necrosis               |    1                          1           1                              |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |    2  1        1              2        1  1              1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +     +  +  +  +  +  +        +  +  +  +     +  +     +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Infiltration Cellular, Lymphocyte    |       2  2     2     2  2  2  2        2  2  2        2  2     2  2     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|             
                                           | 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +  +  A  +  M  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |    2        1                    2        2  2     2  2                  |             
      Inflammation, Acute                  |                            2                                             |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Anorectal Junction, Ulcer            |                               3                                          |             
      Anus, Erosion                        |                                                                          |             
      Anus, Inflammation, Acute            |    2                                                                     |             
      Anus, Inflammation, Chronic Active   |                                                          2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Amyloid Deposition                   |                      4                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Diverticulum                         |       4                                                                  |             
      Necrosis                             |       4                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Bile Stasis                          |                                                                          |             
      Congestion                           |                                        4                                 |             
      Fatty Change                         |                                                                2         |             
      Hematopoietic Cell Proliferation     |       2        2  4        2  2  2        2        2  2  2  2        1   |             
      Infiltration Cellular, Lymphocyte    |    2        1     3  2           2     2     2           2  2        2   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |       3           2                    2                          2      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |    2        2  2  2           2        1  2  2     1  2  2               |             
      Inflammation, Chronic Active         |                            2                                             |             
      Acinus, Atrophy                      |             2                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    | 2           3     2  2        2  2  2  2  2  2     2  2  2  2  1     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Erosion                              |                                  2                                       |             
      Hyperplasia, Focal, Squamous         |                4              3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|             
                                           | 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Squamous                |                                  3           2                           |             
      Infiltration Cellular, Lymphocyte    |             2                             2  2           2               |             
      Inflammation, Acute                  |                                                          3        1      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    1                                                                     |             
      Ulcer                                |                               3              3           3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Erosion                              |                                  2                                       |             
      Infiltration Cellular, Lymphocyte    |    2  2     2     2  1              1     2  2     1     2  2            |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |       2                                                                  |             
      Mucosa, Dilatation                   |    2  2     2     2                                      2  2        2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |       1        1  2  2        2     2     1  2                       1   |             
      Inflammation, Chronic                | 2                                                                        |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2     2  3  3  2     2  2  2  2  2  3  2     2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Congestion                           | 2                                                                        |             
      Cyst                                 |                                  X                                       |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hypertrophy, Diffuse                 |                                                                          |             
      Hypertrophy                          |             2                                                     2      |             
      Pigmentation                         |    2  2        2  2  2     2  2  2  2     2  2     2  2  2  2  2         |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +     M  +  M  M  +  M  M  M  M  M  M  M     +  M  M  +  M  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Pars Distalis, Hyperplasia           |                      2     2     2     2           2  3        2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                           1              3  2            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                   1                                                      |             
      Follicle, Dilatation                 |                      2        3  2                                       |             
      Follicle, Hyperplasia                |             2                    2        1  2           3  4            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|             
                                           | 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Adenomatous             |                                                                          |             
      Inflammation, Acute                  |    4                       4                                             |             
      Mineralization                       |                                                                          |             
      Periovarian Tissue, Cyst             |                X           X  X  X  X        X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    3        3  2  2  3  2  3  2  3     2  3  3     3  2  1  2  2  2  2   |             
      Endometrium, Inflammation, Acute     |    4                                      2                    1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Fibrosis                             |    1           3  2  3     1  3  2        2  3                    3      |             
      Fibrous Osteodystrophy               |             3                                      2                     |             
      Myeloid Cell, Hyperplasia            |    2  2        2  3  2     2  2  2  2  2  2  2                       2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Axillary, Hyperplasia, Lymphoid      |                                                                      2   |             
      Iliac, Hyperplasia, Lymphoid         |    2              3                                                      |             
      Iliac, Inflammation, Acute           |                   4                                                      |             
      Mediastinal, Congestion              | 2                                                                        |             
      Mediastinal, Hyperplasia, Lymphoid   | 2                                   2                          2     2   |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Congestion               |    2           3     2        3     3                                    |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |                2  3  2           2  2  2  2  2     2     3     2  2  2   |             
      Mesenteric, Inflammation, Acute      |             2     4                                                      |             
      Renal, Hyperplasia, Lymphoid         |                   3                                                      |             
      Renal, Inflammation, Acute           |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +     +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  M  +   |             
      Congestion                           |                               3                                          |             
      Hyperplasia, Lymphoid                |       2     2     3  2        2  2        2        2     3           2   |             
      Inflammation, Acute                  |                   4                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Angiectasis                          |                   3                                                      |             
      Hematopoietic Cell Proliferation     | 2  2  3     2  2  3  2     2  3  2  3  2  2  3     2  3  2  2  2  3  3   |             
      Hyperplasia, Lymphoid                |             2  2  3  2                    2  2           3        2  3   |             
      Pigmentation                         | 2  1        2  2     2     2  2  2        2  2     2     2     2     1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Congestion                           | 2                                                                        |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                     2                    2        2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|             
                                           | 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Ectasia                              | 2                                         2                 3            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Alopecia                             | 2                                                                    3   |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Cranium, Fracture                    |                                                                          |             
      Cranium, Inflammation, Chronic Active|                                              3                           |             
      Femur, Fracture                      |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                              2                           |             
      Infiltration Cellular, Lymphocyte    |                            2                 2                           |             
      Mineralization                       | 2  2  2     2     2  2     2     2     2  2        2     2  2  2     1   |             
      Hippocampus, Cyst                    |                                                                          |             
      Meninges, Inflammation, Acute        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Congestion                           |                         2     2        2     2                           |             
      Hemorrhage                           |                                              2                       2   |             
      Infiltration Cellular, Lymphocyte    | 2  2  2     2  2  2  2     2  2  2  2  2  1  2     2  2  2  2  2  2  2   |             
      Mineralization                       |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |       3     2     1                                                      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               1           1           1        2         |             
      Interstitium, Inflammation, Acute    |                   2                                                      |             
      Pleura, Inflammation, Chronic        | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Lumen, Hemorrhage                    |    1           1  3  3  1  2  2              3        2        2  2      |             
      Mucosa, Inflammation, Acute          |                                                    2     1  1  1  1      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   |    2  2        2     2        2  2  1  2  2              2  2     2  2   |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Acute                           |             1                    1                                       |             
      Olfactory Epithelium, Metaplasia     |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|             
                             DAY ON TEST   | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|             
                                           | 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Degeneration |       1           1  2        2           2        2  2                  |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Glands, Inflammation, Acute          |                               2                                          |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2  2        2     3  2        2  2  2  1  2  2     2  2  2  2  1  2  2   |             
      Inflammation, Acute                  |                                                                      1   |             
      Metaplasia, Osseous                  |                                                          3           2   |             
      Regeneration                         |                               2                                          |             
      Renal Tubule, Casts Protein          |                   1  2                    1  2     1  2  1  1  2         |             
      Renal Tubule, Dilatation             |    1  1           2  2     1  2  1  1     2  2     1  2  1  2  2         |             
      Renal Tubule, Necrosis               |                      1        3              2                           |             
      Renal Tubule, Pigmentation           |                               2                                          |             
      Renal Tubule, Regeneration           |    1           1     1     1              1  2     1     1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2     3     3  2     2  2  2  2  2  2  2     2  2     2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 7| 4| 4| 6| 0| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3|                                            |            |
                                           | 8| 8| 9| 9| 7| 7| 6| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  +        +  +  +  +                                             |  45        |
      Infiltration Cellular, Lymphocyte    |                         2  2                                             |     16  1.8|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +        +  +  +  +                                             |  47        |
      Anorectal Junction, Ulcer            |                                                                          |      1  3.0|
      Anus, Erosion                        |                                                                          |      1  2.0|
      Anus, Inflammation, Acute            |                                                                          |      1  2.0|
      Anus, Inflammation, Chronic Active   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +        +  M  +  +                                             |  45        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +        +  +  +  +                                             |  47        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +        +  +  +  +                                             |  47        |
      Diverticulum                         |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +        +  +  +  +                                             |  47        |
      Bile Stasis                          |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  4.0|
      Fatty Change                         |                         1                                                |      3  1.7|
      Hematopoietic Cell Proliferation     |       1                 2  1                                             |     26  1.9|
      Infiltration Cellular, Lymphocyte    |                         1                                                |     21  1.9|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      4  2.3|
      Vacuolization Cytoplasmic            |                   2                                                      |      1  2.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +        +  +  +  +                                             |  47        |
      Infiltration Cellular, Lymphocyte    |                   2        2                                             |     26  1.8|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +        +  +  +  +                                             |  46        |
      Infiltration Cellular, Lymphocyte    |       1  2        1     2  2                                             |     32  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 7| 4| 4| 6| 0| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3|                                            |            |
                                           | 8| 8| 9| 9| 7| 7| 6| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +        +  +  +  +                                             |  47        |
      Angiectasis                          |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      2  2.0|
      Hyperplasia, Focal, Squamous         |                                                                          |      2  3.5|
      Hyperplasia, Squamous                |                                                                          |      4  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      5  1.8|
      Inflammation, Acute                  |                                                                          |      7  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Ulcer                                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +        +  +  +  +                                             |  47        |
      Erosion                              |          2                                                               |      2  2.0|
      Infiltration Cellular, Lymphocyte    |       1                    1                                             |     23  1.6|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Mineralization                       |                   1                                                      |      2  1.5|
      Mucosa, Dilatation                   |                                                                          |     14  1.9|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +        +  +  +  +                                             |  47        |
      Infiltration Cellular, Lymphocyte    |          1              1                                                |     18  1.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +        +  +  +  +                                             |  47        |
      Capsule, Spindle Cell, Hyperplasia   |       2  2        2  2  2  2                                             |     45  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +        +  +  +  +                                             |  47        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  |                   2                                                      |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hypertrophy, Diffuse                 |                                                                          |      1  2.0|
      Hypertrophy                          |                            2                                             |      4  2.0|
      Pigmentation                         |          2        2     2  2                                             |     37  2.0|
      Spindle Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +        +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +        +  +  +  +                                             |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 7| 4| 4| 6| 0| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3|                                            |            |
                                           | 8| 8| 9| 9| 7| 7| 6| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +        M  M  +  +                                             |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +        +  +  +  +                                             |  46        |
      Pars Distalis, Hyperplasia           |          2        2        3                                             |     15  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +        +  +  +  +                                             |  47        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      6  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                         2                                                |      3  1.7|
      Follicle, Dilatation                 |                                                                          |      5  2.2|
      Follicle, Hyperplasia                |                   4                                                      |     10  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +        +  +  +  +                                             |  47        |
      Hemorrhage                           |                                                                          |      2  4.0|
      Hyperplasia, Adenomatous             |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      4  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Periovarian Tissue, Cyst             |                                                                          |      7  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +        +  +  +  +                                             |  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |          2        2     2  2                                             |     38  2.3|
      Endometrium, Inflammation, Acute     |       4                                                                  |      6  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +        +  +  +  +                                             |  47        |
      Fibrosis                             |          3              1  3                                             |     21  2.3|
      Fibrous Osteodystrophy               |                   2                                                      |      4  2.0|
      Myeloid Cell, Hyperplasia            |       2  2              2  2                                             |     34  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +        +  M  +  +                                             |  46        |
      Axillary, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
      Iliac, Inflammation, Acute           |                                                                          |      1  4.0|
      Mediastinal, Congestion              |                                                                          |      2  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      5  2.0|
      Mesenteric, Angiectasis              |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      7  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 7| 4| 4| 6| 0| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3|                                            |            |
                                           | 8| 8| 9| 9| 7| 7| 6| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric, Hemorrhage               |                                                                          |      1  4.0|
      Mesenteric, Hyperplasia, Lymphoid    |       2  2        2        4                                             |     24  2.2|
      Mesenteric, Inflammation, Acute      |                                                                          |      7  2.7|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Inflammation, Acute           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +        +  M  +  +                                             |  43        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |       2  2        2        4                                             |     25  2.2|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +        +  +  +  +                                             |  47        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |       3  2        2     2  2                                             |     45  2.3|
      Hyperplasia, Lymphoid                |                            4                                             |     14  2.4|
      Pigmentation                         |          1        2     1                                                |     28  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +        +  +  +  +                                             |  47        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                         2  4                                             |     10  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +  +        +  +  +  +                                             |  46        |
      Ectasia                              |       2                 2                                                |     11  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +        +  +  +  +                                             |  47        |
      Alopecia                             |                                                                          |      2  2.5|
      Subcutaneous Tissue, Edema           |          2                                                               |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +        +  +  +  +                                             |  47        |
      Cranium, Fracture                    |       X                                                                  |      1     |
      Cranium, Inflammation, Chronic Active|                                                                          |      1  3.0|
      Femur, Fracture                      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +        +  +  +  +                                             |  47        |
      Compression                          |                                                                          |      1  3.0|
      Hemorrhage                           |       2                                                                  |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 7| 4| 4| 6| 0| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3|                                            |            |
                                           | 8| 8| 9| 9| 7| 7| 6| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                   2     2                                                |     28  2.0|
      Hippocampus, Cyst                    |                                                                          |      1     |
      Meninges, Inflammation, Acute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +        +  +  +  +                                             |  47        |
      Congestion                           |                                                                          |      8  2.1|
      Hemorrhage                           |       4                 1                                                |      6  2.0|
      Infiltration Cellular, Lymphocyte    |       2  2        2  1  2  2                                             |     43  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      7  1.9|
      Interstitium, Inflammation, Acute    |                                                                          |      1  2.0|
      Pleura, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +        +  +  +  +                                             |  47        |
      Lumen, Hemorrhage                    |       2              1  2  2                                             |     25  2.0|
      Mucosa, Inflammation, Acute          |          2                                                               |      6  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  2.5|
      Olfactory Epithelium, Degeneration   |          2        2     2  2                                             |     31  1.9|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Acute                           |                                                                          |      3  1.3|
      Olfactory Epithelium, Metaplasia     |                   2                                                      |      3  2.0|
      Respiratory Epithelium, Degeneration |                            2                                             |     12  1.8|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Acute                           |                         1  2                                             |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +        +  +  +  +                                             |  47        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Glands, Inflammation, Acute          |                                                                          |      1  2.0|
      Lumen, Hemorrhage                    |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 2| 7| 4| 4| 6| 0| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3|                                            |            |
                                           | 8| 8| 9| 9| 7| 7| 6| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +        +  +  +  +                                             |  47        |
      Congestion                           |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |       1  2        2        2                                             |     38  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      4  2.3|
      Regeneration                         |                                                                          |      1  2.0|
      Renal Tubule, Casts Protein          |                                                                          |     12  1.3|
      Renal Tubule, Dilatation             |                                                                          |     24  1.5|
      Renal Tubule, Necrosis               |                                                                          |      6  1.5|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                          |     15  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +        +  +  +  +                                             |  47        |
      Angiectasis                          |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                   2        2                                             |     35  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|             
                                           | 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2           2     2                                2     2        2   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Amyloid Deposition                   |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Basophilic Focus                     |                                           X                              |             
      Cyst                                 |             X                                                            |             
      Hematopoietic Cell Proliferation     |    1  2  1              1  2                          1     1  2  1      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |       3                                                                  |             
      Infiltration Cellular, Lymphocyte    | 2     2           2        2  2                                2  2  2   |             
      Inflammation, Chronic                |    3                                                                     |             
      Necrosis                             |                                     3                                   3|             
      Median Lobe, Angiectasis             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2     1  2     1  1     2           2           2     2  2  2  2   |             
      Inflammation, Acute                  |                                                                          |             
      Acinus, Atrophy                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2  2     2  2  2  1  2  2     2     2           2     2     2  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Erosion                              |       3                                                                  |             
      Hyperplasia, Focal, Squamous         |                            3                                             |             
      Hyperplasia, Squamous                |       3              2        2                                          |             
      Infiltration Cellular, Lymphocyte    |                                           2                              |             
      Inflammation, Acute                  |                      1                                                   |             
      Inflammation, Chronic Active         |       3                       2     2     2                              |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Erosion                              |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|             
                                           | 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                2        2  2        2     2                    2         |             
      Inflammation, Acute                  |                         2                                                |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Mucosa, Dilatation                   | 1                       2                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
      Pulp, Inflammation, Acute            |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                         2|             
      Infiltration Cellular, Lymphocyte    | 1  1        2           1  1                          2                  |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Coronary Artery, Inflammation, Acute |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2  2  2  2  2  2  4  2  2     2     2  2        2     2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Degeneration, Fatty                  | 3           1                                3                    3      |             
      Hypertrophy                          |    2  2                                                                  |             
      Pigmentation                         |    3  2  3  2  2  2  2  2  2  2     2     2           2     2  2  3  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  M  M  +  M  M     M     M  M        M     M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Pars Distalis, Cyst                  |       X                                                                  |             
      Pars Distalis, Hyperplasia           | 2        3           2  3           2                 3     2        3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                2        2     2           1                              |             
      Inflammation, Acute                  |                      1                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Dilatation                 |                      2              2                 2                  |             
      Follicle, Hyperplasia                |          1  2  2           2                          2              2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|             
                                           | 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                X              X                                   X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Angiectasis                          |                      3                                                   |             
      Endometrium, Hyperplasia, Cystic     | 3  3     2  2  2  3  3  4  2  3     3     2  2        3     4  2  2  2   |             
      Endometrium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Fibrosis                             | 2  1  1  1     3  4  2  2  3  2     2     1  2        3     2            |             
      Myeloid Cell, Hyperplasia            | 2  2  2  2     2     2  2  2        2     2  2        2     2  2  2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Congestion               |    2                                      4                              |             
      Mesenteric, Hyperplasia, Lymphoid    |    2  2                       2                                2     2  2|             
      Mesenteric, Inflammation, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  M|             
      Hyperplasia, Lymphoid                |    2  2  2     2  2  2     2              2                       2      |             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Acute                  |                                                                      2   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  2  2  2  2  2     3     2           2     2  2  2  3   |             
      Hyperplasia, Lymphoid                |       2        2  2  2  2     2           2           2        2  2      |             
      Pigmentation                         |    1           2  2  2  2  2  2           2           2        2  2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +     M     +  +        +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                   2     2  2  3                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Ectasia                              | 3           2     2  2  2                    2        2     2  2  2  2   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Alopecia                             |                2                             3                          2|             
      Back, Ulcer                          |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|             
                                           | 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Femur, Fracture                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                         2                                                |             
      Mineralization                       | 2        2  2  2  1  2  2  2  1                             1        2  2|             
      Meninges, Inflammation, Acute        |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                       2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2  2  2        2  2  2  2  2  2     2     2           2     2  2  2  2  2|             
      Mineralization                       |                1                                                     1   |             
      Alveolar Epithelium, Hyperplasia     |                                     2                 2                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                              3                           |             
      Interstitium, Inflammation, Chronic  |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Lumen, Hemorrhage                    | 2  2     2  2        2  2  2  2     2     2                    2     1   |             
      Mucosa, Inflammation, Acute          |                   1                                                      |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                     2                                    |             
      Olfactory Epithelium, Degeneration   | 2     1  1  2  2  1  2  2  2              2  2        2     2            |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Acute                           | 1                                                                        |             
      Respiratory Epithelium, Degeneration |       1     2  2     2  2  2                                2            |             
      Turbinate, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|             
                                           | 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    1  2        2  2  2  2  2  2     2     2           2     2  2  2  2  2|             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Casts Protein          | 2              1     2     1              2                              |             
      Renal Tubule, Dilatation             | 2           1  1     2     1              2  2                    2      |             
      Renal Tubule, Necrosis               | 2           1                       2                                    |             
      Renal Tubule, Pigmentation           | 2                                                                        |             
      Renal Tubule, Regeneration           | 3                    1     2  2                       1                  |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +     +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2        2  2  2  2  1  2     2     3           2     2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|             
                             DAY ON TEST   | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|             
                                           | 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    120 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2                    2     2     2  2        2  2  2     2     1         |             
      Inflammation, Acute                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               X                             X            |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     2           2              1         |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Hyperplasia                          |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1                          2     2              2     2                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |          2                                                               |             
      Median Lobe, Angiectasis             |          2                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
      Infiltration Cellular, Lymphocyte    |             2        2     2     2              2  2  2  2  2     1     2|             
      Inflammation, Acute                  |          2                                                               |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2     2  2  2        2  2  2     3  2        2  2  2  2  2  2  2     2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  M  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                             3            |             
      Hyperplasia, Squamous                |                                     2                                    |             
      Infiltration Cellular, Lymphocyte    | 2                    2           2  2                       2            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|             
                             DAY ON TEST   | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|             
                                           | 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    120 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2     1              2           2  2        2     2  2        2         |             
      Inflammation, Acute                  |                            2                                             |             
      Metaplasia, Squamous                 |             2                                                            |             
      Mineralization                       |                                                                1         |             
      Mucosa, Dilatation                   |             1                    1           2     2                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                         1|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                      1  1        1  1              2                     |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                   1      |             
      Coronary Artery, Inflammation, Acute |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   | 2     2  2  2        2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                  2     2                    2            |             
      Hypertrophy                          |                                                                          |             
      Pigmentation                         | 2           2        2     2     2  2        2  2  2  2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     M  M  M        M  M  +  +  M  +  M     M  M  M  M  +  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     M  +  +        +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                   X     X|             
      Pars Distalis, Hyperplasia           | 4        2  3        3                       2  2     2     3  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                     2                                    |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                  3                                       |             
      Follicle, Dilatation                 |                                                                3         |             
      Follicle, Hyperplasia                | 2           1                    3     3                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|             
                             DAY ON TEST   | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|             
                                           | 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    120 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +        +  +  M  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                         X        X                    X     X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
      Endometrium, Hyperplasia, Cystic     | 2     2     2        3     3  2  3  2  2     2  2  2  2  2  2  2  3  2  2|             
      Endometrium, Inflammation, Acute     |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 3           2        2     2     3  2        2  2  2  2  2  2  2  2      |             
      Myeloid Cell, Hyperplasia            | 2     2  2                 2     2  2  2        2     2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                              2                           |             
      Mesenteric, Congestion               |                                     2                    2               |             
      Mesenteric, Hyperplasia, Lymphoid    | 2     2                    3        2        2     2  2        2         |             
      Mesenteric, Inflammation, Acute      |             2                                         2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2     2  2           2  2  3  2  2  2        2  2  2     2  2  2         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |             2                                                            |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     3  3  3              2     2  2  2     2  2  2  2  2  2  2         |             
      Hyperplasia, Lymphoid                |       3              2  2  2                       2     2               |             
      Pigmentation                         | 2           2        2  2  2  2  2  2  2        1  1  2  2  2  2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Cyst                                 |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                                    2        3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      4     3     2                                3      |             
      Inflammation, Acute                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                         2     2        3                          3  2   |             
      Back, Ulcer                          |          3                                                               |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|             
                             DAY ON TEST   | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|             
                                           | 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    120 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Femur, Fracture                      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                            2     2                                       |             
      Mineralization                       | 2        2  2        2  2     2  2  2        2  2  2  2     2     2  2   |             
      Meninges, Inflammation, Acute        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |             2                    2  1        2                       2   |             
      Hyperplasia, Lymphoid                |       3                                                                  |             
      Infiltration Cellular, Lymphocyte    | 2        2  2        2  2  2  2     2        3  2  2  2  2  2  2  2  2  2|             
      Mineralization                       |             2                       1                       1            |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                              4                           |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    | 2           2        2  2  2     2     2     2  2     2     2     2     1|             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |       1                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   | 2           2           2  2  2  2  2  2     2  2  2        2  1        2|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Acute                           |                                                                          |             
      Respiratory Epithelium, Degeneration |          1  2              2     2              1  1        2  2         |             
      Turbinate, Inflammation, Acute       |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Atrophy                              |                         4                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                +            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia, Lymphoid                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|             
                             DAY ON TEST   | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|             
                                           | 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    120 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2        2  2        2  1  2  1  2  2  2     2  2  2  2  2  2        2  2|             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Casts Protein          |             1              1     2           2  1              2         |             
      Renal Tubule, Dilatation             |             1        2     1     2           2  1     1        2         |             
      Renal Tubule, Necrosis               |                                                    1           2         |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |       1  2                 1        1              1        1            |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +        +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       3                                                                  |             
      Infiltration Cellular, Lymphocyte    | 2        2  2        2  2  2  2  3  2        2  2     2  2  2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 6| 7| 4| 0| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3|                                            |            |
                                           | 8| 2| 7| 3| 0| 8| 8| 2| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     M  +  +  +  +  +  +                                             |  49        |
      Infiltration Cellular, Lymphocyte    |                      2     2                                             |     18  1.9|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Amyloid Deposition                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Basophilic Focus                     |                                                                          |      3     |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 1  2                 1     2                                             |     16  1.4|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    | 2  2     2                                                               |     16  1.9|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Necrosis                             |    2                                                                     |      4  2.5|
      Median Lobe, Angiectasis             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 1        2           2     2                                             |     28  1.8|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                            2                                             |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2        2           2  2                                                |     37  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +                                             |  49        |
      Erosion                              |                                                                          |      1  3.0|
      Hyperplasia, Focal, Squamous         |                            3                                             |      3  3.0|
      Hyperplasia, Squamous                |             3        2                                                   |      6  2.3|
      Infiltration Cellular, Lymphocyte    |                                                                          |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 6| 7| 4| 0| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3|                                            |            |
                                           | 8| 2| 7| 3| 0| 8| 8| 2| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |             2                                                            |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      4  2.3|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +                                             |  50        |
      Erosion                              | 2                                                                        |      4  2.0|
      Infiltration Cellular, Lymphocyte    | 2           2           2                                                |     18  1.9|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Mucosa, Dilatation                   |                                                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Pulp, Inflammation, Acute            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +     +  +  +  +  +  +  +                                             |  50        |
      Aorta, Mineralization                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |    1        1                                                            |     13  1.2|
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Coronary Artery, Inflammation, Acute |          3                                                               |      1  3.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +                                             |  50        |
      Capsule, Spindle Cell, Hyperplasia   | 2  2     2  2  2  1  2  2  2                                             |     50  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Degeneration, Fatty                  |             1        2                                                   |      9  2.1|
      Hypertrophy                          |                                                                          |      2  2.0|
      Pigmentation                         |    2     2  2        2  2  3                                             |     37  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  M  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M     M  M  M  M  M  M  M                                             |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +                                             |  48        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hyperplasia           |    2                                                                     |     18  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 6| 7| 4| 0| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3|                                            |            |
                                           | 8| 2| 7| 3| 0| 8| 8| 2| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                      2                                                   |      6  1.8|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Follicle, Dilatation                 |             2                                                            |      5  2.2|
      Follicle, Hyperplasia                |          2  1        2                                                   |     13  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +  +  +  +  +  +  +                                             |  49        |
      Periovarian Tissue, Cyst             |    X                                                                     |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Endometrium, Hyperplasia, Cystic     |    3     2  2        4  2  2                                             |     43  2.4|
      Endometrium, Inflammation, Acute     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |    2        2        2                                                   |     32  2.1|
      Myeloid Cell, Hyperplasia            |    2     2  2        2  2  2                                             |     35  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  M  +  +  +                                             |  49        |
      Hyperplasia, Lymphoid                |                      2                                                   |      2  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                      2                                                   |      5  2.4|
      Mesenteric, Hyperplasia, Lymphoid    | 2        2              2                                                |     17  2.1|
      Mesenteric, Inflammation, Acute      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +  +  +  M  +  +  +                                             |  48        |
      Hyperplasia, Lymphoid                | 2  2     2           2  2                                                |     29  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Pigmentation                         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |    2     2  2        2  2  1                                             |     39  2.1|
      Hyperplasia, Lymphoid                |                                                                          |     16  2.1|
      Pigmentation                         |    2     2  2  2     2  2  1                                             |     33  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 6| 7| 4| 0| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3|                                            |            |
                                           | 8| 2| 7| 3| 0| 8| 8| 2| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     M  +  +  +  +  +  +                                             |  48        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +  +  +  +  +  +  +                                             |  50        |
      Ectasia                              |             2        2  2                                                |     18  2.3|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Alopecia                             |          3                                                               |      9  2.4|
      Back, Ulcer                          |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +  +  +  +  +                                             |  49        |
      Femur, Fracture                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.0|
      Mineralization                       |    2        2  2           3                                             |     31  1.9|
      Meninges, Inflammation, Acute        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Congestion                           | 2                       3                                                |      2  2.5|
      Hemorrhage                           |    2                       2                                             |      8  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    | 2        2  2  2     2  2  2                                             |     42  2.0|
      Mineralization                       |    1                    2                                                |      7  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  3.5|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |    2        2           2                                                |     28  1.9|
      Mucosa, Inflammation, Acute          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4| 6| 7| 4| 0| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3|                                            |            |
                                           | 8| 2| 7| 3| 0| 8| 8| 2| 7| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    120 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   |             2        2  2  2                                             |     31  1.9|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Respiratory Epithelium, Degeneration |          2  2           1  2                                             |     19  1.7|
      Turbinate, Inflammation, Acute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   3        |
      Infiltration Cellular, Lymphocyte    |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |          3                                                               |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    | 2  2     2  2  2     2  2  2                                             |     42  1.9|
      Metaplasia, Osseous                  |          2                                                               |      1  2.0|
      Mineralization                       |          3                                                               |      1  3.0|
      Pelvis, Dilatation                   |          3                                                               |      1  3.0|
      Renal Tubule, Casts Protein          |                                                                          |     11  1.5|
      Renal Tubule, Dilatation             |                                                                          |     16  1.6|
      Renal Tubule, Necrosis               |          2           1                                                   |      7  1.6|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |          2           1                                                   |     13  1.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |          +                                                               |   1        |
      Dilatation                           |          3                                                               |      1  3.0|
      Infiltration Cellular, Lymphocyte    |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |    2     2  2        2  2  2                                             |     39  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|             
                                           | 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                              2                           |             
      Inflammation, Acute                  |                                                             3            |             
      Inflammation, Chronic                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                3                                      4        4         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bile Stasis                          |                                  2                                       |             
      Focal Cellular Change                |                                        X                                 |             
      Hematopoietic Cell Proliferation     | 2           2  2                 2  2                 3              2   |             
      Infarct                              |                   2                                                      |             
      Infiltration Cellular, Lymphocyte    |                                        1                                 |             
      Inflammation, Acute                  |                2                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                   3              4           2                           |             
      Centrilobular, Fatty Change          |                   1                                                      |             
      Periportal, Inflammation, Chronic    |                                                                   2  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2           1              1              2           2            |             
      Acinus, Atrophy                      |                                                 3                        |             
      Acinus, Hyperplasia                  | 1                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      4   |             
      Hyperplasia, Glandular               |                                                                          |             
      Infiltration Cellular, Lymphocyte    |       2           2  1     1     2  2           2           2            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                             3            |             
      Infiltration Cellular, Lymphocyte    |             2                                                            |             
      Inflammation, Acute                  |    3                                                           2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|             
                                           | 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                             3            |             
      Ulcer                                |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                      2                                                   |             
      Infiltration Cellular, Lymphocyte    |             2                    2                                      2|             
      Inflammation, Acute                  |                      3              2                                    |             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Dilatation                   |                                                                         2|             
      Mucosa, Hyperplasia                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                        1           1     1              1|             
      Inflammation, Chronic                |                                  2           2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                         2|             
      Pigmentation                         |       2                          2     2     2  2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  M  +  M  +  M  M  +  +  +  +  M  M  M  M  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                  2     2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             1                    1              2                        |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Dilatation                 |                                                 2                        |             
      Follicle, Hyperplasia                |                                  2           2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|             
                                           | 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                      1           2           2           2        2      |             
                                            __________________________________________________________________________|             
   Penis                                   |                      +        +     +                          +  +      |             
      Concretion                           |                                                                          |             
      Inflammation, Acute                  |                      4        4     4                          3  4      |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                          +                                   +         |             
      Abscess                              |                                                                4         |             
      Cyst                                 |                            3                                             |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 3                                                                        |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2        2                                2     2        2            |             
      Inflammation, Acute                  |          2                    4     3                 4  2     4         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                              +                           |             
      Inflammation, Chronic                |                                              4                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                 4                    3            |             
      Granuloma Sperm                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
      Interstitial Cell, Hyperplasia       |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            | 2  2  2  2  2  2     2  2     3  2  2  2  3  2     2  2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3                              |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Iliac, Hyperplasia, Lymphoid         |                               2                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                         2|             
      Mesenteric, Congestion               |       2  3                 3  2              2  2                        |             
      Mesenteric, Hemorrhage               |                                                          3               |             
      Mesenteric, Hyperplasia, Lymphoid    | 2  2  2        3              4           2  2  2     2              2  2|             
      Mesenteric, Inflammation, Acute      |                      3           3                                       |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                | 1  2  2  2     2     2                       2           2  2  2  2      |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|             
                                           | 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  3  1  2     3  3  2  3  2  3  2        4  1  2  2  2  2  2|             
      Hyperplasia, Lymphoid                |                                  2           3  2                    2   |             
      Pigmentation                         |                   1     2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +|             
      Cyst                                 |       X                 2                    X                           |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                           2                              |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Head, Inflammation, Acute            |                                                                          |             
      Head, Inflammation, Chronic          |                               2                                          |             
      Inguinal, Abscess                    |                                                                          |             
      Inguinal, Ulcer                      |                                                                          |             
      Prepuce, Abscess                     |                                                                   4      |             
      Prepuce, Ulcer                       | 4                          4                                             |             
      Scrotal, Abscess                     | 4              4                                                         |             
      Scrotal, Ulcer                       |          4           4        4                       4           4      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |          3                                                               |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Head, Abscess   |                                                                          |             
      Subcutaneous Tissue, Head,           |                                                                          |             
          Inflammation, Acute              |                                                                          |             
      Tail, Inflammation, Acute            |                                                                          |             
      Tail, Necrosis                       |                                                       4                  |             
      Thoracic, Alopecia                   |                                                                          |             
      Ventral, Alopecia                    | 2                                                        2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|             
                                           | 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Mineralization                       | 2  2     2  2        2  2  2  2  2     2        2  3        3  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2  2     2              2     2           2  2           2            |             
      Hemorrhage                           |                                           1              1               |             
      Infiltration Cellular, Lymphocyte    | 1  2  2  2     2  2  1  2  2  2  2  2  2     2  2        1  2  2  2  2  2|             
      Mineralization                       |                   1                                                      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       3                                                                  |             
      Interstitium, Inflammation, Acute    |                                     2  1                       2         |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Peribronchiolar, Inflammation, Acute |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |       2     2  2  2  2  1     2  2  1  2           2  2     3  1     2   |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |    2                                                                    2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   |    1  1  2  2  2  1        2  2  2  2  2        2  2  2           2  1  2|             
      Respiratory Epithelium, Degeneration |                                        2              1                  |             
      Turbinate, Inflammation, Acute       |                         1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion                      |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                        2                                 |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  1     2  2  2  2  2  2  2  2     2  2  2     2  2  2  2  2  2  2|             
      Inflammation, Acute                  |                                     3                    3               |             
      Inflammation, Chronic                |                                                                          |             
      Cortex, Cyst                         |                                                                      X   |             
      Pelvis, Dilatation                   |                3              2           1  3                       2   |             
      Pelvis, Inflammation, Acute          |                               3                                          |             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|             
                             DAY ON TEST   | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|             
                                           | 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Casts Protein          |             2                                1                           |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Dilatation             |    1        2                    2           1                           |             
      Renal Tubule, Hyperplasia            |                                        2                                 |             
      Renal Tubule, Mineralization         |                                                          2               |             
      Renal Tubule, Necrosis               |                                              1  1                        |             
      Renal Tubule, Regeneration           |    2  1     2                 2  2     1  1  2  1  1        1        1  2|             
                                            __________________________________________________________________________|             
   Ureter                                  | +                                                     +        +  +      |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +              +                                          |             
      Calculus Micro Observation Only      |                               X                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              3                           |             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Ectasia                              | 3                          3     3           3        2                  |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1  2  2  2  1        1           2     2  1  2  2     2     2        1  2|             
      Inflammation, Acute                  |                               4     2                          3         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|             
                                           | 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                                  |             
      Infiltration Cellular, Lymphocyte    |       2                                               1  2  2  1         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bile Stasis                          |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |    1           1  1     1  2     2        2  2  2        1           2   |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                       1                  |             
      Inflammation, Acute                  |                                              2                           |             
      Inflammation, Chronic                |                2                                               2         |             
      Necrosis                             |                                                          2               |             
      Centrilobular, Fatty Change          |                                                                          |             
      Periportal, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Artery, Inflammation, Chronic Active |                                                                      4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                2           2     1              2     2        2         |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Glandular               |                         2                                                |             
      Infiltration Cellular, Lymphocyte    |       2  2  2  2           2  2  1  2  1  2  1  2  2     2     2     2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|             
                                           | 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          2                                                               |             
      Infiltration Cellular, Lymphocyte    |                   2        2  2        2  2     2                       1|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Mucosa, Dilatation                   |                                                                      2   |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                          +                     |             
      Pulp, Inflammation, Acute            |                         3                          2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1     1           2                                2     1         |             
      Inflammation, Chronic                |    2     2                                      2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  1  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                  2                             2     2   |             
      Pigmentation                         |                2                                                     3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  M  +  M  M  +  M  +  M  +  +  M  +  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2                                            2           1         |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Dilatation                 |                         2                                               2|             
      Follicle, Hyperplasia                |                                                 1                    2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|             
                                           | 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   | +  +                                   +  +  +  +  +                     |             
      Concretion                           |                                                                          |             
      Inflammation, Acute                  | 4  4                                   4  4  4  4  3                     |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +        M           +  +  +     +        +     +  +            |             
      Abscess                              |                                                    4     4  4            |             
      Cyst                                 |          4                          X                                    |             
      Inflammation, Acute                  |          4                       4                                       |             
      Inflammation, Chronic                |                               3                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                            2        2                          2         |             
      Inflammation, Acute                  |       4  3                             4     4                           |             
      Inflammation, Chronic                |    3              3                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +                          +        +                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3  3                    2                                3   |             
      Granuloma Sperm                      | 2                                                           3            |             
      Hemorrhage                           |       4                                                                  |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |    2  2  2  2  2  2     2  2  2  2     2  2  2  2  2     2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                   3           2                                          |             
      Iliac, Hyperplasia, Lymphoid         |    2  3                             2  2                 2               |             
      Inguinal, Hyperplasia, Lymphoid      |                                     2                                    |             
      Mediastinal, Hyperplasia, Lymphoid   |          2                          2                                   2|             
      Mesenteric, Congestion               |          2                 3     2     2     2  2        3     3     2  2|             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    | 2              2     2  2  3  2  2  2  2  2  2  2        2     2     2   |             
      Mesenteric, Inflammation, Acute      |    3                    2                                                |             
      Renal, Congestion                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2  2     2  2  2     2  3  2     2  2     2  2  2  2  2  2  2  2  2  2|             
      Inflammation, Acute                  |                         2                                                |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|             
                                           | 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  3  2  2  3  2  3  2  2  2  2  2  2  2  2  3  1  2  2  2  2     2  2   |             
      Hyperplasia, Lymphoid                |             2  2        3                       2              2     2   |             
      Pigmentation                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectopic Parathyroid Gland            |                      X                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                      2                                                   |             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Chronic                |                                              3                           |             
      Ulcer                                |                   4                             4                 4      |             
      Head, Inflammation, Acute            |       2                                                                  |             
      Head, Inflammation, Chronic          |                                                                          |             
      Inguinal, Abscess                    | 4                                                                        |             
      Inguinal, Ulcer                      |                                                                          |             
      Prepuce, Abscess                     |                   4                                                      |             
      Prepuce, Ulcer                       |    4     4                    4  4  4                    4               |             
      Scrotal, Abscess                     |       4                                                     4     4      |             
      Scrotal, Ulcer                       |                                        4     4     4                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                        3                                 |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                      2                                                   |             
      Subcutaneous Tissue, Head, Abscess   |    3                                                                     |             
      Subcutaneous Tissue, Head,           |                                                                          |             
          Inflammation, Acute              |                               2                                          |             
      Tail, Inflammation, Acute            |                                                                          |             
      Tail, Necrosis                       |                                                                          |             
      Thoracic, Alopecia                   |    3                                                                     |             
      Ventral, Alopecia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|             
                                           | 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                2         |             
      Mineralization                       | 2        2  2  2        2  2  2  2  2     2     2  2  3     2  3        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3  2                                                   |             
      Hemorrhage                           |                      2                                               2   |             
      Infiltration Cellular, Lymphocyte    | 2  2  2     2  2  2     2  2  2  2  2  2  2  2  2  2     2  1  1     2   |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                    2                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2  2                                                            |             
      Interstitium, Inflammation, Acute    |                                                                          |             
      Interstitium, Inflammation, Chronic  |    2                                                                     |             
      Peribronchiolar, Inflammation, Acute |                                              2                           |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lumen, Hemorrhage                    |    2        2  2        3     2  2     2  2     1  2  1  2     2  2  2   |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                         2|             
      Olfactory Epithelium, Degeneration   |    2     2  2  2  2     1  2     1     2     1  2  2  2  1     2     1  2|             
      Respiratory Epithelium, Degeneration |    2                                   1        1     1  1               |             
      Turbinate, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2  2  2     2  2  3  2  2  2  1  2  2  2  2  2  2  2     2  2  2     2  2|             
      Inflammation, Acute                  |                                        3                                 |             
      Inflammation, Chronic                |          3                                                               |             
      Cortex, Cyst                         |                                                    X                     |             
      Pelvis, Dilatation                   | 3                 3                       3  2              3     2      |             
      Pelvis, Inflammation, Acute          |    3              2                          2              3            |             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|             
                                           | 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Casts Protein          |                                                                      2   |             
      Renal Tubule, Cyst                   |                               2                          2               |             
      Renal Tubule, Dilatation             |    2           1        1  1                    1              1     2  1|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |                            2                                             |             
      Renal Tubule, Necrosis               |    1           2                                                     2   |             
      Renal Tubule, Regeneration           |    2  2     1  2  2     2  2  1  2     2     2  1  2  1  2     2     2  2|             
                                            __________________________________________________________________________|             
   Ureter                                  |                                     +        +              +            |             
      Dilatation                           |                                     1                       2            |             
      Inflammation, Acute                  |                                              3                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                        +     +                    +      |             
      Calculus Micro Observation Only      |                                        X                          X      |             
      Inflammation, Acute                  |                                              3                           |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |       X                                                                  |             
      Ectasia                              | 3     3              3        2  3  1     3  3  3        2  3     2      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 1              1           2  2  2        2     2        2     2     2  1|             
      Inflammation, Acute                  |    4  2           4                          4                           |             
      Inflammation, Chronic                |          2                                                               |             
      Inflammation, Chronic Active         |                                        4                    2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 5| 5| 6| 7| 5| 2| 7|                                            |            |
                             DAY ON TEST   | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1|                                            |            |
                                           | 9| 8| 9| 3| 0| 9| 3| 8| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      6  1.7|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ulcer                                |                         3                                                |      4  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Bile Stasis                          |                                                                          |      1  2.0|
      Focal Cellular Change                |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 1        1     2                                                         |     21  1.7|
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.0|
      Inflammation, Acute                  | 1                                                                        |      3  1.7|
      Inflammation, Chronic                |                      2                                                   |      3  2.0|
      Necrosis                             |       1                                                                  |      5  2.4|
      Centrilobular, Fatty Change          |                                                                          |      1  1.0|
      Periportal, Inflammation, Chronic    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |     11  1.7|
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Glandular               |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2  2     1        2     2  1                                             |     30  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 5| 5| 6| 7| 5| 2| 7|                                            |            |
                             DAY ON TEST   | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1|                                            |            |
                                           | 9| 8| 9| 3| 0| 9| 3| 8| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Acute                  |                            1                                             |      4  1.8|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                   2        3                                             |      4  2.3|
      Infiltration Cellular, Lymphocyte    | 2  1           2        2                                                |     14  1.9|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mucosa, Dilatation                   |                                                                          |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Pulp, Inflammation, Acute            |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Aorta, Mineralization                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      9  1.2|
      Inflammation, Chronic                |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2  2  2  2  2  2  2  2                                             |     59  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypertrophy                          |                                                                          |      4  2.0|
      Pigmentation                         |                                                                          |      8  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M                                             |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Cyst                  | X                                                                        |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |    1        1                                                            |      8  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 5| 5| 6| 7| 5| 2| 7|                                            |            |
                             DAY ON TEST   | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1|                                            |            |
                                           | 9| 8| 9| 3| 0| 9| 3| 8| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       | 2        2                                                               |      2  2.0|
      Follicle, Dilatation                 |                                                                          |      3  2.0|
      Follicle, Hyperplasia                |                                                                          |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Granuloma Sperm                      |                      3     4                                             |      3  3.7|
      Infiltration Cellular, Lymphocyte    |    2                 2  2                                                |      9  1.9|
                                            __________________________________________________________________________|____________|
   Penis                                   | +  +  +        +     +                                                   |  17        |
      Concretion                           |                3                                                         |      1  3.0|
      Inflammation, Acute                  |    4  4        4     4                                                   |     16  3.9|
      Inflammation                         | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |  12        |
      Abscess                              |                                                                          |      4  4.0|
      Cyst                                 |                                                                          |      3  3.5|
      Inflammation, Acute                  |                                                                          |      2  4.0|
      Inflammation, Chronic                |                         3                                                |      3  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      8  2.0|
      Inflammation, Acute                  | 3        3  2  3                                                         |     14  3.2|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |       2              4                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                2           3                                             |      9  2.8|
      Granuloma Sperm                      |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myeloid Cell, Hyperplasia            | 2  2     2  2  2  2  2  2  2                                             |     51  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 5| 5| 6| 7| 5| 2| 7|                                            |            |
                             DAY ON TEST   | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1|                                            |            |
                                           | 9| 8| 9| 3| 0| 9| 3| 8| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                            3                                             |      2  3.0|
      Hyperplasia, Lymphoid                |                2                                                         |      4  2.3|
      Iliac, Hyperplasia, Lymphoid         | 3           2  3     3                                                   |     10  2.4|
      Inguinal, Hyperplasia, Lymphoid      |       2                                                                  |      2  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      4  2.0|
      Mesenteric, Congestion               | 2     2        2  4                                                      |     20  2.4|
      Mesenteric, Hemorrhage               |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    | 2  2           2  2  2  3                                                |     32  2.2|
      Mesenteric, Inflammation, Acute      |                                                                          |      4  2.8|
      Renal, Congestion                    |                2                                                         |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  53        |
      Hyperplasia, Lymphoid                | 2        2  2  2  2  1  2                                                |     38  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |             2                                                            |      1  2.0|
      Hematopoietic Cell Proliferation     | 3  2  3  3  2  2     2  2  3                                             |     54  2.2|
      Hyperplasia, Lymphoid                |                                                                          |     10  2.2|
      Pigmentation                         |                   1                                                      |      4  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |  53        |
      Cyst                                 |                                                                          |      3  2.0|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                         2                                                |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alopecia                             |          2                 2                                             |      4  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |    2                                                                     |      2  2.5|
      Ulcer                                |                                                                          |      3  4.0|
      Head, Inflammation, Acute            |                   2                                                      |      2  2.0|
      Head, Inflammation, Chronic          |                      3  2                                                |      3  2.3|
      Inguinal, Abscess                    |                                                                          |      1  4.0|
      Inguinal, Ulcer                      |    4                                                                     |      1  4.0|
      Prepuce, Abscess                     |                                                                          |      2  4.0|
      Prepuce, Ulcer                       |             4                                                            |      9  4.0|
      Scrotal, Abscess                     |                                                                          |      5  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 5| 5| 6| 7| 5| 2| 7|                                            |            |
                             DAY ON TEST   | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1|                                            |            |
                                           | 9| 8| 9| 3| 0| 9| 3| 8| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Scrotal, Ulcer                       | 4  4  4  4  4  4     4  4                                                |     16  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      2  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Subcutaneous Tissue, Head, Abscess   |                            3                                             |      2  3.0|
      Subcutaneous Tissue, Head,           |                                                                          |            |
          Inflammation, Acute              |                                                                          |      1  2.0|
      Tail, Inflammation, Acute            |                   1                                                      |      1  1.0|
      Tail, Necrosis                       |                                                                          |      1  4.0|
      Thoracic, Alopecia                   |                                                                          |      1  3.0|
      Ventral, Alopecia                    |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Mineralization                       | 2  2  1  2  2  2  2                                                      |     40  2.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                            2                                             |     11  2.1|
      Hemorrhage                           |                         2  2                                             |      6  1.7|
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2     2  2  2  1                                             |     50  1.9|
      Mineralization                       |                            2                                             |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.3|
      Interstitium, Inflammation, Acute    |       2        1                                                         |      5  1.6|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation, Acute |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Lumen, Hemorrhage                    |    2     2  1     1     2  1                                             |     36  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 5| 5| 6| 7| 5| 2| 7|                                            |            |
                             DAY ON TEST   | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1|                                            |            |
                                           | 9| 8| 9| 3| 0| 9| 3| 8| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Acute          |                      2                                                   |      1  2.0|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   | 2        2  2  1  2  2     2                                             |     41  1.8|
      Respiratory Epithelium, Degeneration |                                                                          |      7  1.3|
      Turbinate, Inflammation, Acute       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Erosion                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2  2     2  2  1  2  2  2  2                                             |     53  2.0|
      Inflammation, Acute                  |       3                                                                  |      4  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Cortex, Cyst                         |                                                                          |      2     |
      Pelvis, Dilatation                   | 2  3                 3                                                   |     14  2.5|
      Pelvis, Inflammation, Acute          | 2        2                                                               |      7  2.4|
      Pelvis, Inflammation, Chronic        |    2                                                                     |      1  2.0|
      Pelvis, Inflammation, Chronic Active |                2                                                         |      1  2.0|
      Renal Tubule, Casts Protein          |                            2                                             |      4  1.8|
      Renal Tubule, Cyst                   |                                                                          |      2  2.0|
      Renal Tubule, Dilatation             |                            2                                             |     13  1.4|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      2  2.0|
      Renal Tubule, Necrosis               |    2                                                                     |      6  1.5|
      Renal Tubule, Regeneration           | 1  2     2  2     1                                                      |     36  1.6|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                      +                                                   |   8        |
      Dilatation                           |                      2                                                   |      3  1.7|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   5        |
      Calculus Micro Observation Only      |                                                                          |      3     |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 5| 5| 5| 6| 7| 5| 2| 7|                                            |            |
                             DAY ON TEST   | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1|                                            |            |
                                           | 9| 8| 9| 3| 0| 9| 3| 8| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  2.5|
      Calculus Gross Observation           |    X                                                                     |      1     |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Ectasia                              | 2  3                                                                     |     19  2.6|
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                            1                                             |     27  1.7|
      Inflammation, Acute                  | 4  3                 4                                                   |     10  3.4|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |       2  4  4  3                                                         |      6  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|             
                             DAY ON TEST   | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|             
                                           | 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                    1           2         |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anorectal Junction, Erosion          |                                                                          |             
      Anus, Erosion                        |                                                                          |             
      Anus, Inflammation, Acute            |          3                                                               |             
      Anus, Inflammation, Chronic Active   |                                                                         3|             
      Anus, Ulcer                          | 4                                                                    4   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                              4                           |             
      Inflammation, Chronic                |                                                    3                     |             
      Ulcer                                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |    1                 1  2                          2           2  1      |             
      Infarct                              |                                                                         4|             
      Infiltration Cellular, Lymphocyte    |                      1                             1           2         |             
      Inflammation, Acute                  |                         2                                               2|             
      Inflammation, Chronic                |          2                                                               |             
      Necrosis                             |                                                                         2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                2                                                         |             
      Infiltration Cellular, Lymphocyte    |          2              1     1     1                          1         |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                    1                     |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1  2        2  2  2  1  2  1  1           2              2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|             
                             DAY ON TEST   | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|             
                                           | 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                      2  2|             
      Infiltration Cellular, Lymphocyte    | 2                    2     2        1  2              2        2         |             
      Mucosa, Dilatation                   |                                                                          |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                    +|             
      Pulp, Inflammation, Acute            |    2                                                                    3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2           1                 2                                 |             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic                |                            2                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 2                                                                        |             
      Ventricle Right, Thrombosis          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                             2            |             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2     2  2  2  2  2  2  2  2  2  2  2     2  2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Pigmentation                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  +  +  M  +  +  M  +  M  M  +  M  M  +  +  +  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Follicle, Cyst                       |                                                             2            |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|             
                             DAY ON TEST   | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|             
                                           | 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1     2           2                                                      |             
      Inflammation, Acute                  |                                              4                       3   |             
      Inflammation, Chronic                |                                                    3                     |             
      Inflammation, Chronic Active         |                                                                         3|             
                                            __________________________________________________________________________|             
   Penis                                   | +                 +  +        +           +     +  +     +              +|             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  | 4                             4           4     4  4     4              4|             
      Necrosis                             |                   4  4                                                  4|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +        +                          +                     |             
      Abscess                              |                4                                   4                     |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                         3                                                |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Infiltration Cellular, Lymphocyte    | 2                                      2                       2         |             
      Inflammation, Acute                  |                   3  3           1                 3                     |             
      Inflammation, Chronic Active         |    3                          4                                         3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +                                                         |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
      Inflammation, Acute                  |                                              3                           |             
      Interstitial Cell, Hyperplasia       |          2                                                               |             
      Tunic, Inflammation, Chronic Active  |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     1                                    |             
      Myeloid Cell, Hyperplasia            |       2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                               1                                          |             
      Inflammation, Acute                  |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                         2     2  3                                3      |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                              3     4        3            |             
      Lumbar, Hyperplasia, Lymphoid        |                                              3                           |             
      Mediastinal, Hyperplasia, Lymphoid   |                               2              2                           |             
      Mesenteric, Congestion               |                   4                                               2      |             
      Mesenteric, Hyperplasia, Lymphoid    |          2  2        1     2  2  2        2     2  2     2  2  3  2     2|             
      Mesenteric, Inflammation, Acute      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|             
                             DAY ON TEST   | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|             
                                           | 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2  2  2        1  2  2  2  2           2     2  1        2  2  4  2  2|             
      Pigmentation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Hematopoietic Cell Proliferation     | 2  4  2  2  2  3  2  3  2  3  3  3  1  1  2  2  2  3  2  2  3  1  3  2  3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |          1                          2                 2              1   |             
      Capsule, Inflammation, Chronic Active|                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |    2                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                    4                 4   |             
      Foot, Ulcer                          |                4                                                         |             
      Head, Inflammation, Chronic          |                                                                          |             
      Inguinal, Inflammation, Acute        |    2                                                                     |             
      Inguinal, Ulcer                      |                                                 4                        |             
      Neck, Abscess                        |                                                                   4      |             
      Prepuce, Ulcer                       | 4  4              4                                   4                  |             
      Scrotal, Abscess                     |                                                                          |             
      Scrotal, Inflammation, Chronic Active|                                                       3                  |             
      Scrotal, Ulcer                       | 4                    4  4  4  4  4        4  4              4           4|             
      Subcutaneous Tissue, Head, Abscess   |                                                                          |             
      Tail, Inflammation, Chronic          |                                                       2                  |             
      Tail, Ulcer                          |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                      +              +           +|             
      Abscess                              |       4                                                                  |             
      Head, Abscess                        |       3                                      2              3           3|             
      Head, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|             
                             DAY ON TEST   | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|             
                                           | 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                2         |             
      Mineralization                       |    2     2           2     2  2  2     2  2  2  2  2  2  2     2  2  1  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       2        2              2                       2              2   |             
      Granuloma                            |                                                                   3      |             
      Hemorrhage                           |       2     2              2     2     2              2        3     1   |             
      Infiltration Cellular, Lymphocyte    | 1  2  2  2  2  1  2  2  2  2  2  1     2  2  2  2  2  1  2  2  2  2  1  1|             
      Inflammation, Acute                  |                                                                         2|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                        2                                 |             
      Arteriole, Inflammation, Acute       |                                                                          |             
      Artery, Inflammation, Acute          |                                                                          |             
      Interstitium, Inflammation, Acute    |    1           1                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    | 2     1        2        2  2  2           2        2  2     2        2  2|             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                   1                    2                                 |             
      Olfactory Epithelium, Degeneration   | 2     1  2     2  2     2  1  2                       2           2     2|             
      Respiratory Epithelium, Degeneration | 1                             2                                         2|             
      Septum, Inflammation, Acute          |                                                                          |             
      Turbinate, Congestion                |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                1                          2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                4                                                         |             
      Hemorrhage                           |                                  2                                       |             
      Infiltration Cellular, Lymphocyte    | 1  2  2  2  2        2  2  2  2  2  2     2  2  2  2     2  2  2  2     2|             
      Inflammation, Acute                  |    3              4                                                     2|             
      Inflammation, Chronic Active         |                3                                                         |             
      Metaplasia, Osseous                  |                                                                   2      |             
      Pelvis, Dilatation                   |                      2  2                 2     2  3                     |             
      Pelvis, Inflammation, Acute          |                            1  2                                          |             
      Renal Tubule, Casts Protein          |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|             
                             DAY ON TEST   | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|             
                                           | 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Cyst                   |                                                                         2|             
      Renal Tubule, Dilatation             | 2                             2     1                 2                  |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Necrosis               |                                     2                                   2|             
      Renal Tubule, Regeneration           | 1  2     1                 1  2     1                       1  2        2|             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                    +                     |             
      Dilatation                           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +                           |             
      Inflammation, Acute                  |                                              4                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2  3        2           1     3  2  3        2     2|             
      Infiltration Cellular, Lymphocyte    | 1  2     1     2        2              2  2     2  2     2  2  2  2  1   |             
      Inflammation, Acute                  |                   4  2     2  4              2                          4|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|             
                                           | 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2     1     2                                2         |             
      Inflammation, Acute                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anorectal Junction, Erosion          |                                        2                                 |             
      Anus, Erosion                        |                                        2           2                     |             
      Anus, Inflammation, Acute            |                                                                          |             
      Anus, Inflammation, Chronic Active   |                                                                          |             
      Anus, Ulcer                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Hematopoietic Cell Proliferation     |          1     2  2              2           2  1                       1|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    1                    2              2                    2  1     1   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +              +                  |             
      Artery, Inflammation, Chronic        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2        1                          1  2  1                 1        1|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2  1  2  2     2  2        2        1  2        1        2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|             
                                           | 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       1        2  2     2                                                |             
      Infiltration Cellular, Lymphocyte    |                         2     2        2  2     2  1  2        2  2  2   |             
      Mucosa, Dilatation                   |                               2        2  1           1                 2|             
      Submucosa, Edema                     |                               3                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
      Infiltration Cellular, Lymphocyte    |    2     1                                1                    1         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ventricle Right, Thrombosis          |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2  2  2  2     2  2  2  3  2     2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Hypertrophy                          |          2                                                  2            |             
      Pigmentation                         |       2  2  2                 2           2                    1     2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  M  M  M  +  +  M  M  M  +  M  M  M  M  +  M  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   1                                         2            |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Hyperplasia                |                   2           3                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|             
                                           | 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1     2                                                        2   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                    3                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +        +           +           +        +  +                 +   |             
      Abscess                              |       4                                                                  |             
      Inflammation, Acute                  |                            4           4        4  4                 4   |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +                    +                       +     +               |             
      Abscess                              |                            4                                             |             
      Cyst                                 |    X                                                     X               |             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
      Inflammation, Chronic                |    3                                                                     |             
      Inflammation, Chronic Active         |       3                                            3                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2     2  2     2  2     1                          2  2  2     2      |             
      Inflammation, Acute                  |       3        3                    4                                    |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                +                 +                                       |             
      Dilatation                           |                3                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                                                   |             
      Inflammation, Acute                  |                                                                          |             
      Interstitial Cell, Hyperplasia       |                   1                                                      |             
      Tunic, Inflammation, Chronic Active  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          2               |             
      Inflammation, Acute                  |       2                                                                  |             
      Iliac, Hyperplasia, Lymphoid         |                                                                      2   |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |       2                                   2  2                           |             
      Mesenteric, Congestion               |          3     3           2  3           3  3              2  3         |             
      Mesenteric, Hyperplasia, Lymphoid    |    2     2     3     2  2     2        2  2  2     1     2  2  2  2  2  2|             
      Mesenteric, Inflammation, Acute      |                   3                             2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|             
                                           | 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |       2                          2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3                                                               |             
      Hyperplasia, Lymphoid                |       2  2  2  2  2  2     2  2     2     2     2  2        2  2  2     2|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         3|             
      Hematopoietic Cell Proliferation     | 2  2  2  2     3  2  2  2  2  2  3     3  2  3  3  2  2  2  2  1  2  2  2|             
      Hyperplasia, Lymphoid                |             1     2           2                                3  3     2|             
      Pigmentation                         |    2                          1     2        1              1     1      |             
      Capsule, Inflammation, Chronic Active|                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                   X                                    |             
      Hyperplasia, Lymphoid                |                                                             2  4  2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |       2                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Foot, Ulcer                          |                                                                          |             
      Head, Inflammation, Chronic          |                         2                                                |             
      Inguinal, Inflammation, Acute        |                                                                          |             
      Inguinal, Ulcer                      |                                                                          |             
      Neck, Abscess                        |                                                                          |             
      Prepuce, Ulcer                       |       4        4                                4                    4   |             
      Scrotal, Abscess                     |                                                    4                     |             
      Scrotal, Inflammation, Chronic Active|                                                                          |             
      Scrotal, Ulcer                       |                         4  4                                             |             
      Subcutaneous Tissue, Head, Abscess   |       3                                                                  |             
      Tail, Inflammation, Chronic          |                                                                          |             
      Tail, Ulcer                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                      +                                 |             
      Abscess                              |                                                                          |             
      Head, Abscess                        |                                                                          |             
      Head, Inflammation, Chronic Active   |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|             
                                           | 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                        2                                 |             
      Mineralization                       | 2     1  2  2        1     2  2  2  2  1  2     2     3     2  2  2     2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                         2              1           1  2     2        2   |             
      Infiltration Cellular, Lymphocyte    |    2  2  1  2  1  2  2  2  2  2  2        2  2  2  2     1  2  2  2  2  2|             
      Inflammation, Acute                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                         2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Arteriole, Inflammation, Acute       |                                              4                           |             
      Artery, Inflammation, Acute          |                                              4                           |             
      Interstitium, Inflammation, Acute    |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    | 2  2  2  2  2  2  2        2  3     1  2  1  2  2     2     2  1  1  2  2|             
      Mucosa, Inflammation, Acute          | 2                                                                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                              2                           |             
      Olfactory Epithelium, Degeneration   | 2     1     1  2        1  2     1           2     2     2  2        2   |             
      Respiratory Epithelium, Degeneration | 2        1                                      2                       1|             
      Septum, Inflammation, Acute          |                      2                                                   |             
      Turbinate, Congestion                |    3                                                                     |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Pelvis, Dilatation                   |                2        2                          2                 2   |             
      Pelvis, Inflammation, Acute          |                2                                                         |             
      Renal Tubule, Casts Protein          |                                        2                                1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|             
                                           | 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Dilatation             |          2        1           1        2     2  2              1        2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Mineralization         |             2                                                            |             
      Renal Tubule, Necrosis               |       1                                1  1                    2        1|             
      Renal Tubule, Regeneration           | 2     2     2     2     2     2     1  2  2  2        2     1     1  2  2|             
                                            __________________________________________________________________________|             
   Ureter                                  |                +                                                         |             
      Dilatation                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       3        2                                   2                 3   |             
      Infiltration Cellular, Lymphocyte    |          2  2     2  2  2  1  2     1  2  2     2        2  2     2  2   |             
      Inflammation, Acute                  |                4                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 4| 5| 7| 7| 7| 5| 3|                                            |            |
                             DAY ON TEST   | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0|                                            |            |
                                           | 9| 5| 3| 0| 8| 9| 0| 9| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Infiltration Cellular, Lymphocyte    | 1                    2                                                   |      8  1.6|
      Inflammation, Acute                  |                   2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Anorectal Junction, Erosion          |                                                                          |      1  2.0|
      Anus, Erosion                        |                                                                          |      2  2.0|
      Anus, Inflammation, Acute            |                                                                          |      1  3.0|
      Anus, Inflammation, Chronic Active   |                                                                          |      1  3.0|
      Anus, Ulcer                          |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 1  2  1           2                                                      |     17  1.5|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    | 2                                                                        |     10  1.5|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |       2           2                                                      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2  1  2  2     2           2                                             |     18  1.4|
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 4| 5| 7| 7| 7| 5| 3|                                            |            |
                             DAY ON TEST   | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0|                                            |            |
                                           | 9| 5| 3| 0| 8| 9| 0| 9| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    | 2  2  1  2  2  2  2        2                                             |     34  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                   2                                                      |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
      Ulcer                                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      6  1.8|
      Infiltration Cellular, Lymphocyte    |                                                                          |     17  1.9|
      Mucosa, Dilatation                   |                                                                          |      5  1.6|
      Submucosa, Edema                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Pulp, Inflammation, Acute            |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2                 2                                                      |      9  1.6|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ventricle Right, Thrombosis          |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2  2        2  2  2  2                                             |     53  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                   2                                                      |      2  2.0|
      Hypertrophy                          |                   2                                                      |      3  2.0|
      Pigmentation                         |    2                                                                     |     10  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 4| 5| 7| 7| 7| 5| 3|                                            |            |
                             DAY ON TEST   | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0|                                            |            |
                                           | 9| 5| 3| 0| 8| 9| 0| 9| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  M  M  M  +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicle, Hyperplasia                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |    2           2                                                         |      8  1.8|
      Inflammation, Acute                  |                                                                          |      2  3.5|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                         +                                                |  17        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Acute                  |                         4                                                |     13  4.0|
      Necrosis                             |                                                                          |      4  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +                                                                     |  10        |
      Abscess                              |                                                                          |      3  4.0|
      Cyst                                 |                                                                          |      2     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |    2                                                                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Infiltration Cellular, Lymphocyte    | 2                 2  2                                                   |     16  1.9|
      Inflammation, Acute                  |    3  2                                                                  |      9  2.8|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +                                                                  |   4        |
      Dilatation                           |       3                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                      3                                                   |      3  2.7|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  1.5|
      Tunic, Inflammation, Chronic Active  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 4| 5| 7| 7| 7| 5| 3|                                            |            |
                             DAY ON TEST   | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0|                                            |            |
                                           | 9| 5| 3| 0| 8| 9| 0| 9| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  1.0|
      Myeloid Cell, Hyperplasia            | 2  2  2  2     2  2  2  2  2                                             |     56  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  A  +  +  +  +  +                                             |  59        |
      Congestion                           |                3                                                         |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      5  2.4|
      Iliac, Inflammation, Acute           |                3                                                         |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      3  3.3|
      Lumbar, Hyperplasia, Lymphoid        |                            2                                             |      2  2.5|
      Mediastinal, Hyperplasia, Lymphoid   |       2                                                                  |      6  2.0|
      Mesenteric, Congestion               |                      3  3                                                |     12  2.8|
      Mesenteric, Hyperplasia, Lymphoid    | 2  2  2              2     2                                             |     35  2.0|
      Mesenteric, Inflammation, Acute      |                3                                                         |      3  2.7|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  A  +  +  +  +  +                                             |  54        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    2           2  3  2  2  2                                             |     38  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     | 2  3  3  2     3  2  2     2                                             |     56  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.2|
      Pigmentation                         |                         1                                                |     11  1.4|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                      2                                                   |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M                                             |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alopecia                             |    2                                                                     |      3  2.0|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
      Ulcer                                |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 4| 5| 7| 7| 7| 5| 3|                                            |            |
                             DAY ON TEST   | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0|                                            |            |
                                           | 9| 5| 3| 0| 8| 9| 0| 9| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Foot, Ulcer                          |                            4                                             |      2  4.0|
      Head, Inflammation, Chronic          |                                                                          |      1  2.0|
      Inguinal, Inflammation, Acute        |                                                                          |      1  2.0|
      Inguinal, Ulcer                      |          4                                                               |      2  4.0|
      Neck, Abscess                        |                                                                          |      1  4.0|
      Prepuce, Ulcer                       |                                                                          |      8  4.0|
      Scrotal, Abscess                     |                                                                          |      1  4.0|
      Scrotal, Inflammation, Chronic Active|                                                                          |      1  3.0|
      Scrotal, Ulcer                       |    4  4     4              4                                             |     16  4.0|
      Subcutaneous Tissue, Head, Abscess   |                                                                          |      1  3.0|
      Tail, Inflammation, Chronic          |                                                                          |      1  2.0|
      Tail, Ulcer                          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   6        |
      Abscess                              |                                                                          |      1  4.0|
      Head, Abscess                        |                                                                          |      4  2.8|
      Head, Inflammation, Chronic Active   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  2.0|
      Mineralization                       | 2  2  2  2     2  3  2                                                   |     41  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      5  2.0|
      Granuloma                            |                2                                                         |      2  2.5|
      Hemorrhage                           |       1                    1                                             |     16  1.8|
      Infiltration Cellular, Lymphocyte    | 2  2  1  2  2  2  2  2  2  1                                             |     55  1.8|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                2                                                         |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                2                                                         |      2  2.0|
      Arteriole, Inflammation, Acute       |                                                                          |      1  4.0|
      Artery, Inflammation, Acute          |                                                                          |      1  4.0|
      Interstitium, Inflammation, Acute    |                                                                          |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 4| 5| 7| 7| 7| 5| 3|                                            |            |
                             DAY ON TEST   | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0|                                            |            |
                                           | 9| 5| 3| 0| 8| 9| 0| 9| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lumen, Hemorrhage                    | 2  2     2     2  2  2  2  1                                             |     40  1.9|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                1        2                                                |      5  1.6|
      Olfactory Epithelium, Degeneration   |    2  1  1              2                                                |     27  1.7|
      Respiratory Epithelium, Degeneration |                   1                                                      |      8  1.5|
      Septum, Inflammation, Acute          |                                                                          |      1  2.0|
      Turbinate, Congestion                |                                                                          |      1  3.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    | 2  2  2  2     3  2  2  2  1                                             |     52  2.0|
      Inflammation, Acute                  |                                                                          |      3  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Pelvis, Dilatation                   |                                                                          |      9  2.1|
      Pelvis, Inflammation, Acute          |    2  1                                                                  |      5  1.6|
      Renal Tubule, Casts Protein          |                4                                                         |      4  2.3|
      Renal Tubule, Cyst                   |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             | 1              4  2                                                      |     15  1.8|
      Renal Tubule, Hyperplasia            |                      2                                                   |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                4  2                                                      |      9  1.8|
      Renal Tubule, Regeneration           | 1  3           3  2  2                                                   |     29  1.8|
                                            __________________________________________________________________________|____________|
   Ureter                                  |             +                                                            |   3        |
      Dilatation                           |             1                                                            |      3  1.7|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 4| 5| 7| 7| 7| 5| 3|                                            |            |
                             DAY ON TEST   | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0|                                            |            |
                                           | 9| 5| 3| 0| 8| 9| 0| 9| 9| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |       2                    3                                             |     15  2.3|
      Infiltration Cellular, Lymphocyte    |       1  2     2  2  2  2  2                                             |     36  1.8|
      Inflammation, Acute                  |                                                                          |      7  3.1|
      Inflammation, Chronic Active         |    4                                                                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|             
                                           | 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             1                             1                    2         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anorectal Junction, Inflammation,    |                                                                          |             
           Acute                           |                                           2                              |             
      Anus, Erosion                        |                                                                4         |             
      Anus, Ulcer                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anorectal Junction, Ulcer            |                   4                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                           X                              |             
      Cyst                                 |                      2                                                   |             
      Hematopoietic Cell Proliferation     |                2                    1     2           1        2        2|             
      Hyperplasia                          |                                        3                                 |             
      Hypertrophy                          |                                           2                              |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                     2                                    |             
      Inflammation, Acute                  |                                                                         1|             
      Necrosis                             |       3                       1                             2            |             
      Bile Duct, Hyperplasia               |             2                                                            |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         X|             
      Infiltration Cellular, Lymphocyte    |       2     2     2     1     2                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2     2     1  1        2  2  2              2           2     2  2|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|             
                                           | 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
      Erosion                              |                   3           2                                          |             
      Infiltration Cellular, Lymphocyte    |       2                             1                                    |             
      Inflammation, Acute                  |                                                                      2   |             
      Mucosa, Dilatation                   |             1           2           2     2                    1        2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic         |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1              1                                   2|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                2                                                         |             
      Inflammation, Chronic Active         |                                                                2         |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  2  2  1  2  2  2  2  2  2  1  2  2  2  1     2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |             2                                                            |             
      Pigmentation                         |             2        1  2  1  2     2     2                    2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  M  M  M  M  M  +  +  M  M  M  +  M  +  +  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                               2   |             
      Inflammation, Acute                  |                                                                          |             
      Follicle, Dilatation                 |                                                                          |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                     3                                    |             
      Infiltration Cellular, Lymphocyte    |                   2  2                                                  2|             
      Inflammation, Acute                  |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|             
                                           | 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 3                                                  2                     |             
                                            __________________________________________________________________________|             
   Penis                                   |       +              +     +                       +  +  +  +           +|             
      Inflammation, Acute                  |                      4     3                       4                    4|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation                         |                                                                          |             
      Necrosis                             |       4                                               4                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +     +                          +  +        +      |             
      Abscess                              |                                                       4                  |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                            2                                      4      |             
      Inflammation, Chronic Active         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |             2     2                 2     2                              |             
      Inflammation, Acute                  |       4                    2           3     3                           |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +           +              +                          +            |             
      Dilatation                           |                                                             2            |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1        3                                                   |             
      Inflammation, Acute                  | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2  2     2  2  2     2  2  2     2  2     2        2  2        4  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                         2|             
      Inguinal, Hyperplasia, Lymphoid      |                                                    3                     |             
      Mediastinal, Hyperplasia, Lymphoid   |       2                                                                  |             
      Mesenteric, Autolysis                |                                                                          |             
      Mesenteric, Congestion               |                               3     2                                    |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    | 2     2        2     2  2  2  2           2  2     2        2  2  2      |             
      Mesenteric, Inflammation, Acute      |                                           2           3                 3|             
      Renal, Hyperplasia, Lymphoid         |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  +  +  +  +  +  M  +  +  A  +  M  +  M  +  +  +  +  M  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |             2     2  2  2        1  2     2           2        2     2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|             
                                           | 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  1  4     2  3  3  2     2        2  2  2  2     2  2     2  3  1  1  2|             
      Hyperplasia, Lymphoid                |                               2     2                          3         |             
      Necrosis                             |                               3                                          |             
      Pigmentation                         | 1  2     1     1     2     1        2  2                    2     2  1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Alopecia                             |       3                                                                  |             
      Ulcer                                |                                                                         4|             
      Foot, Ulcer                          |                                                                          |             
      Head, Abscess                        |                4                                                         |             
      Head, Ulcer                          |                               3                                          |             
      Neck, Alopecia                       |                                                                          |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                                          2               |             
      Prepuce, Ulcer                       |       4              4     4                                4            |             
      Scrotal, Abscess                     | 4                                                                        |             
      Scrotal, Ulcer                       |                      4                             4  4                  |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Head, Abscess   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Inflammation, Chronic Active|                4                                                         |             
      Femur, Hyperostosis                  |                                                                          |             
      Tibia, Fracture                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                3                                                         |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |          2           2     2  2  2  2        2     1  2  2  2  2        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|             
                                           | 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                3                                                         |             
      Congestion                           |    2                 2                       3  2                 4      |             
      Hemorrhage                           |                                                                1         |             
      Infiltration Cellular, Lymphocyte    | 2  1  2  2  2  2        1  2  2  2  2     2  2  2     2  2  2  2     2  2|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                            2                                             |             
      Interstitium, Inflammation, Acute    |                                                                2         |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |             1        2  2     2  1  2     2           2        2     2  2|             
      Mucosa, Inflammation, Acute          |                                              1        2           2      |             
      Olfactory Epithelium, Degeneration   |       1           2     2     2     2     2     1     1  2  2  1     2   |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                                          |             
      Sinus, Inflammation, Acute           |                4                                                         |             
      Turbinate, Congestion                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2     2  1  2  2  2  2  2  2  2     2  2     2  2  2  2  2     2  2|             
      Inflammation, Acute                  |                                        3                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Cortex, Cyst                         |                                                                X         |             
      Pelvis, Calculus Micro Observation   |                                                                          |             
          Only                             |                                                                          |             
      Pelvis, Dilatation                   |    3                                   1                                 |             
      Pelvis, Hemorrhage                   |                                                                          |             
      Pelvis, Inflammation, Acute          |       2                    2                    3                       2|             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Renal Tubule, Casts Protein          |    1                                                                     |             
      Renal Tubule, Dilatation             |    1        1     2  2  1  1        2     2                              |             
      Renal Tubule, Necrosis               |       2     1           1           1                          2         |             
      Renal Tubule, Regeneration           |       2     1                 1     1     1                    2     1   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|             
                             DAY ON TEST   | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|             
                                           | 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                            X                                             |             
      Calculus Micro Observation Only      |                                                                          |             
      Ectasia                              |    2  3                                2           2        2        2  3|             
      Infiltration Cellular, Lymphocyte    | 1  2        2  1  2     2     2  2  2     2        2           2  2     2|             
      Inflammation, Acute                  |       4              4     3                                            2|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|             
                                           | 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 1                                                        1  1            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anorectal Junction, Inflammation,    |                                                                          |             
           Acute                           |                                                                          |             
      Anus, Erosion                        |                                                                          |             
      Anus, Ulcer                          |                               4  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anorectal Junction, Ulcer            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2        1        2           1  2     2  1           1|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Infarct                              |                                                                   4      |             
      Infiltration Cellular, Lymphocyte    |             1           1                                                |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                2                    3  2                                 |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |             1           2                          2     2  2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1  2           2     2  2              2  2     2     2  2  2  2  2  2|             
      Mineralization                       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                      2   |             
      Hyperplasia, Focal, Squamous         |                                                                      3   |             
      Infiltration Cellular, Lymphocyte    |                                                                         1|             
      Inflammation, Acute                  |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|             
                                           | 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             2                                                            |             
      Erosion                              |                      2                                                   |             
      Infiltration Cellular, Lymphocyte    |             2           2     2           2  1     2  2  2              1|             
      Inflammation, Acute                  |                                                                      2   |             
      Mucosa, Dilatation                   |             2              1           1  1              1           1   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic         |                                                          3               |             
      Aorta, Mineralization                |                                                          2               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1                    1  1                                         2   |             
      Inflammation, Acute                  |                                                                3         |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                2                                                         |             
      Atrium, Thrombosis                   |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   | 2  2  1  2  2  2  2  2     2  2  1  2  2  1  2  2  2  2  3  2  1  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |       2                                                                  |             
      Pigmentation                         |       2                    1           2                    2           1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  M  M  +  +  M  M  M  +  M  M  M  +  +  +  +  M  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Intermedia, Hyperplasia         |                            3                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
      Inflammation, Acute                  |                                                                          |             
      Follicle, Dilatation                 |                            3                          2                 3|             
      Follicle, Hyperplasia                | 2           2              3                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                  3                    4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 112                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|             
                                           | 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |    3                                                                     |             
      Inflammation, Chronic Active         |                                                    1           4         |             
                                            __________________________________________________________________________|             
   Penis                                   |                +     +     +  +     +              +  +        +         |             
      Inflammation, Acute                  |                            2  4     4              2  4                  |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                      1                                                   |             
      Inflammation                         |                                                                4         |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +  +                          +                              |             
      Abscess                              |             4                                                            |             
      Cyst                                 |                X                                                         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2        2     2                       2           1  1     2  2   |             
      Inflammation, Acute                  |                               4     3  4  3           2        4  2      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                        +                                 |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
      Inflammation, Acute                  |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Myeloid Cell, Hyperplasia            | 3  2  2  2  2     2     2  2  2     2  2        2  2  1  2  2  2     2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                               3           3                              |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                      2                    2  2                           |             
      Mesenteric, Autolysis                |                                                                          |             
      Mesenteric, Congestion               | 3  3  2     4        3              2           2        2               |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                    3                     |             
      Mesenteric, Hyperplasia, Lymphoid    |       2                 2     2     2  2  2           3     2  2     2   |             
      Mesenteric, Inflammation, Acute      |             2     3                          2              3     2  3   |             
      Renal, Hyperplasia, Lymphoid         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2  2        2  2  2  2           2  2     2     2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 113                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|             
                                           | 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2     2  2  2  1  2  2  2  2  2  2  2        2  2  2  2  2     2  2|             
      Hyperplasia, Lymphoid                |                         2                                   4            |             
      Necrosis                             |                                                                   4      |             
      Pigmentation                         | 2              1     2              1           1        1           2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                   3              3                 2                    2|             
      Ulcer                                |                4                 4                    3                  |             
      Foot, Ulcer                          |                                                                          |             
      Head, Abscess                        |                                                                          |             
      Head, Ulcer                          |                                                                          |             
      Neck, Alopecia                       |                      2                                                   |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                                                          |             
      Prepuce, Ulcer                       |                4  4                       4        4  4                  |             
      Scrotal, Abscess                     |                                                                          |             
      Scrotal, Ulcer                       |                               4                    4                     |             
      Subcutaneous Tissue, Edema           |                2                                                         |             
      Subcutaneous Tissue, Head, Abscess   |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Inflammation, Chronic Active|                                                                          |             
      Femur, Hyperostosis                  |                                                                          |             
      Tibia, Fracture                      |                                                                         X|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
      Inflammation, Acute                  |                                                                   2      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Mineralization                       |       2     2     2     3  3  2  2  2  2           2  1  3  2  2  2  3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 114                                                               
NTP Experiment-Test: 05701-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:24:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|             
                                           | 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|             
 _____________________________________________