National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5094

TR 371 Rat Pathology Tables

NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108883

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                        X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Developmental Malformation           | X  X     X     X                          X                              |             
      Fatty Change                         |                                     2                 2                  |             
      Focal Cellular Change                | X        2  X  X     X  X     X     X  X  X        X        X           X|             
      Granuloma                            | 2              2                                   2     1  2        2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                     2                    2           2   |             
      Arteriole, Thrombosis                |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2     1     3     2  2  1  2     2  1        3  2  1           2     1|             
      Portal, Inflammation, Chronic        | 1  2     2  2  2     1  2  1  2     2  2  2     2  2  2  2  2  2  1  2   |             
      Venule, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Fat, Necrosis                        |                                     4                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1           4              3     2  2                    2  2         |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                        3                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                     4  3              4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Mucosa, Dilatation                   | 2  1     2  2                 1     2     2        2  1  2  2  2  1      |             
      Mucosa, Erosion                      |                                     2           1                        |             
      Mucosa, Pigmentation                 |                                                                2         |             
      Mucosa, Ulcer                        |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  2     2  2  2     2  1  1  3     3  1  1     2  2  2  2  1  1  1  2  2|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                     2                                    |             
      Atrium, Thrombosis                   |                                                                          |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 3        4  2  2     1              2  2        2  1  1  2  1  4  2     2|             
      Hyperplasia                          |          2  2        2  2           2  2              1     2            |             
      Hypertrophy                          |             2                                                            |             
      Pigmentation                         | 2  2     2  1  2     2  2  2  2     2  2  2     2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1        2                          2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                         3|             
      Pars Distalis, Cyst                  |          X  X           X           X                                    |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |    3        3                                   2  2                     |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                     1                                    |             
      C-Cell, Hyperplasia                  |                1                    1  2           2        2  1  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                | 2           1  2           2                       2        2  2  2     2|             
      Inflammation, Chronic Active         |    3                 3              2  2                                 |             
      Duct, Ectasia                        |                                           3                 2            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |          X           X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                        2           2                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                    +  +  +               |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                2                                            2            |             
      Myeloid Cell, Hyperplasia            |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2        2                                                  2         |             
      Inflammation, Acute                  |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mesenteric, Congestion               |                               2                                          |             
      Mesenteric, Edema                    |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |          2  2           2           1              2  2     2  2     2   |             
      Mesenteric, Inflammation, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  M  M  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                         |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2  3     2  2  2     2        2     2  2  2     2  2  2     2  3     2  2|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  1     3  4  2     2  2     3     2     2     1  2  2  2  2  2     2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                             3            |             
      Pigmentation                         | 2  2     2     2     1  2  2  3     3  3  2     1  2  3  3  3  2     2  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +     +  +  +  +     +  M  +     +  +  +  M  +  +  +  +  +|             
      Congestion                           |                         2                                                |             
      Cyst                                 |                               X                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Ectasia                      | 2  2     3  2  3     3  2  2  3     3     2        4  4     3  2  2  3  2|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |    2                                4  2           2  2  2     2     3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Head, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                     X                                    |             
      Cranium, Osteopetrosis               | 3                                                           4            |             
      Femur, Fibrous Osteodystrophy        |                                     X                                    |             
      Femur, Osteopetrosis                 | 3  2                                                        4            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Compression                          |                            X        X  X              X        X  X      |             
      Gliosis                              |                      3                                                   |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                      2                                                   |             
      Lateral Ventricle, Hemorrhage        |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         3                             2                  |             
      Hemorrhage                           |                                                       2     1     2      |             
      Infiltration Cellular, Lymphocyte    | 2  2     2  2  2     2  2  2  2     2  2  2     2  2  2  2  2  2  2  2  2|             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1        2  1                          2           1  1  2  1  2  2  1|             
      Alveolus, Mineralization             |                                                                          |             
      Arteriole, Mineralization            |             2  2        2  2  2     2  2  2           2  2  2     2  1  2|             
      Interstitium, Inflammation, Chronic  |          1  1  1     1                                         1  2  1  1|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Peribronchiolar, Inflammation, Acute |                                                    4                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                    3                     |             
      Lumen, Hemorrhage                    | 3  2           2     2     2  2           2     2           2  1  2     3|             
      Mucosa, Inflammation, Acute          |    2     2     2     2              1           2  4           2     2   |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 2           1        3                                1  2               |             
      Olfactory Epithelium, Degeneration   | 2  2     2  2  2     3  1  2  2     2  2  2     2     2     2  2  2  2  2|             
      Olfactory Epithelium, Erosion        |                                                    2           2         |             
      Respiratory Epithelium, Degeneration |    3     2  1  1     2        2           1     1              2  1  2   |             
      Respiratory Epithelium, Erosion      |                                                    3                     |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Atrophy                              |                                                                          |             
      Cataract                             |                               4                                          |             
      Retina, Degeneration                 |                               4                                          |             
      Sclera, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Nephropathy, Chronic                 | 3  2     4  2  2     3  1  2  2     4  2  2     2  3  2  2  2  3  2  3  2|             
      Pelvis, Calculus Micro Observation   |                                                                          |             
          Only                             |                                                                          |             
      Renal Tubule, Cyst                   |                                     X                                    |             
      Renal Tubule, Hyperplasia            |                                                                3         |             
      Renal Tubule, Pigmentation           | 2  2     2  2  3     2     2  2     2  2  2     2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                2                                                         |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Parasite Metazoan                    |    X           X                    X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Angiectasis                          |       2                                                                  |             
      Developmental Malformation           |                            X                                             |             
      Fatty Change                         |                                     2                                    |             
      Focal Cellular Change                | X  X  X                    X     X  X  X     X        X     X     X  X   |             
      Granuloma                            |    2  2                             1  1     2                       2   |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Necrosis                             |                                                                          |             
      Arteriole, Thrombosis                |                                                                          |             
      Bile Duct, Hyperplasia               | 1     2     1  2  1     2  1     2  1  2     2  2     2     1  2     1   |             
      Portal, Inflammation, Chronic        | 2  2  2     2  1  1  1  2  1     2  2  2     2  2     2     2  2  1  2   |             
      Venule, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Acinus, Atrophy                      |       2                    4     2  3     4                    1  1  2   |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic Active         |                            1                          4                  |             
      Ulcer                                | 4                                                     4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Mucosa, Dilatation                   |    2        1  2  2              2  2        1        2              1   |             
      Mucosa, Erosion                      |                         1                                                |             
      Mucosa, Pigmentation                 |                                                                          |             
      Mucosa, Ulcer                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Cardiomyopathy, Chronic              | 3  2  2     2  2  1  1  2  1        1  3  3  2  2     2     3  2  2  3   |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Degeneration, Fatty                  |       2     1  2  2  2     1     2  1                 2        1     2   |             
      Hyperplasia                          |    2           1                       1                    2     1      |             
      Hypertrophy                          |                            2              1                          2   |             
      Pigmentation                         | 2  2  2     2  2  2  2  2  2     2  2  2  2  2  2     2     2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  M     +     +  +  +  +   |             
      Hyperplasia                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Hyperplasia                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +     +  +  +  +  +  +     +  +  +  +  +  +     M     +  +  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |    X        X     X  X  X                                      X         |             
      Pars Distalis, Hemorrhage            |             3                                                            |             
      Pars Distalis, Hyperplasia           |       2                 2  3                                             |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      C-Cell, Hyperplasia                  |                2                       1              2           2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +  +  +  +  +  +     +  M  +  +  +  +     +     +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                       3                  |             
      Inflammation, Chronic                |       2              2     2           2  1           2     1     2      |             
      Inflammation, Chronic Active         |                2        2                    2                       2   |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Periovarian Tissue, Cyst             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Ectasia                              |                         2                                                |             
      Hemorrhage                           |                   4                                                      |             
      Prolapse                             |                                  X                                       |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Myelofibrosis                        |       1     1                       2        2                           |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Congestion                           |                                     2                                    |             
      Hyperplasia, Lymphoid                |                                  2     2                                 |             
      Inflammation, Acute                  |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mesenteric, Congestion               |                            1                                2            |             
      Mesenteric, Edema                    |                      3                                                   |             
      Mesenteric, Hyperplasia, Lymphoid    | 2     2                          2     2              2           2  2   |             
      Mesenteric, Inflammation, Acute      |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  M  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Congestion                           |       2                             3                                    |             
      Cyst                                 |                X                                                         |             
      Hyperplasia, Lymphoid                | 2  2  2     2  2     2     2     2  2  2  2     2     2     2  2  2  2   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Hematopoietic Cell Proliferation     |    2  2     3  1     2  2  2     2  3     2  3        2     2  3  3  2   |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Pigmentation                         | 3  2  2     2  2     2     3     2  2  3  2  2  3     2     2  2  2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  M  +  +  +     +  +  +  +  +  M     +     +  +  +  +   |             
      Congestion                           |                                                             2            |             
      Cyst                                 |                            X                                             |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |       3                                                                  |             
      Acinus, Ectasia                      |    3  2        2  4              2  3  3        2     3     2  3  3      |             
      Acinus, Hyperplasia                  |             2                    2                                       |             
      Duct, Ectasia                        | 2              2  2     2           2        3  2     3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Head, Inflammation, Chronic Active   |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Compression                          |                X                             X        X                  |             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                   3     2                    2  2                        |             
      Hydrocephalus                        |                                                                          |             
      Lateral Ventricle, Hemorrhage        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |    1                    2                                      1         |             
      Infiltration Cellular, Lymphocyte    | 2  2  2     2  2  2  2  2  2     2  2  2  2  2  2     2     2  2  2  2   |             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2        2        2           1     2                       1  2  2   |             
      Alveolus, Mineralization             |                                                                          |             
      Arteriole, Mineralization            |    2           2     2                       2  2           1  2         |             
      Interstitium, Inflammation, Chronic  |    1        1                    1     2     1                    1  2   |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Peribronchiolar, Inflammation, Acute | 4                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Hemorrhage                    |    3  2        3     2           2  2  1     1        3     2  2  2  4   |             
      Mucosa, Inflammation, Acute          |       2     2     2  1           2        2  2  3           1  2  1  2   |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   |    2  2     2  2  2  2  1  2     2  2  2  2  2        2     2  2  2  2   |             
      Olfactory Epithelium, Erosion        |                                                                          |             
      Respiratory Epithelium, Degeneration |    1        1     1        2     1  1  2  1  1        1     1  2  2  1   |             
      Respiratory Epithelium, Erosion      |                   2                                                      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Hemorrhage                           |                                                                      2   |             
      Inflammation, Acute                  |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +     +                       +                        |             
      Atrophy                              |                                                 4                        |             
      Cataract                             |                4        3                                                |             
      Retina, Degeneration                 |                4  2     4                                                |             
      Sclera, Mineralization               |                3  2                                                      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Nephropathy, Chronic                 | 2  3  2     2  3  2  2  1  2     3  3  3  2  2  3     3     2  2  3  3   |             
      Pelvis, Calculus Micro Observation   |                                                                          |             
          Only                             |                                                                      X   |             
      Renal Tubule, Cyst                   |       X                                                                  |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Pigmentation           | 2  2  2     2  3  2  2  2  2     2  2  2  2  2  1     2     2  2  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +                                             |  50        |
      Parasite Metazoan                    |       X                                                                  |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +                                             |  50        |
      Erosion                              |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Developmental Malformation           |                                                                          |      6     |
      Fatty Change                         |                                                                          |      3  2.0|
      Focal Cellular Change                |          X  X  X     X                                                   |     29  2.0|
      Granuloma                            |                                                                          |     12  1.8|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Necrosis                             |          2                                                               |      4  2.0|
      Arteriole, Thrombosis                |                         X                                                |      1     |
      Bile Duct, Hyperplasia               | 3  1  1     2  2        2  2                                             |     38  1.7|
      Portal, Inflammation, Chronic        | 2     1  2  2  2     1  3  2                                             |     47  1.8|
      Venule, Thrombosis                   |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  +                                             |  50        |
      Acinus, Atrophy                      |       2        2     1                                                   |     18  2.2|
      Acinus, Hyperplasia                  |                            3                                             |      1  3.0|
      Duct, Ectasia                        |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +                                             |  50        |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Ulcer                                |    4                                                                     |      6  3.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +                                             |  50        |
      Mucosa, Dilatation                   | 2  2  1  2              2                                                |     27  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Erosion                      |    3                    3  3                                             |      6  2.2|
      Mucosa, Pigmentation                 |                                                                          |      1  2.0|
      Mucosa, Ulcer                        |                         2                                                |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              | 2     2  3  2  2     2  2  2                                             |     48  1.9|
      Inflammation, Acute                  |                         4                                                |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium, Thrombosis                   | X  X                                                                     |      2     |
      Ventricle, Thrombosis                |                         X                                                |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Degeneration, Fatty                  | 1     1  2     2     2  2  2                                             |     33  1.8|
      Hyperplasia                          |       1  1  3                                                            |     16  1.7|
      Hypertrophy                          |                                                                          |      4  1.8|
      Pigmentation                         | 2  2  2  2  2  2     2  2  2                                             |     50  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  M  +     +  +  M                                             |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |     10     |
      Pars Distalis, Hemorrhage            |             3  4                                                         |      3  3.3|
      Pars Distalis, Hyperplasia           |                                                                          |      7  2.4|
      Pars Intermedia, Angiectasis         |    3                                                                     |      1  3.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +                                             |  50        |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |       1  1           1                                                   |     17  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +                                             |  49        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |    2        2  2           1                                             |     21  1.8|
      Inflammation, Chronic Active         |       2              3                                                   |     10  2.3|
      Duct, Ectasia                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Periovarian Tissue, Cyst             |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Ectasia                              |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Prolapse                             |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                            +                                             |   4        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  M  +  +  +  +     +  +  +                                             |  49        |
      Myelofibrosis                        |       2              4                                                   |      8  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.0|
      Inflammation, Acute                  |                         4                                                |      1  4.0|
      Mediastinal, Hemorrhage              |                            4                                             |      1  4.0|
      Mesenteric, Congestion               | 2                                                                        |      4  1.8|
      Mesenteric, Edema                    |                                                                          |      1  3.0|
      Mesenteric, Hyperplasia, Lymphoid    |       2                                                                  |     17  1.9|
      Mesenteric, Inflammation, Acute      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +                                             |  47        |
      Congestion                           |    2           2                                                         |      5  2.2|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                | 2  2  2  2  2  2     2                                                   |     41  2.0|
      Inflammation, Acute                  |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     | 2     3  3  2  2     3  2  2                                             |     41  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
      Pigmentation                         | 3     2  2  2  1     1  2                                                |     44  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +  +                                             |  46        |
      Congestion                           |                3           2                                             |      4  2.3|
      Cyst                                 |                                                                          |      2     |
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +                                             |  50        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Acinus, Ectasia                      | 2  2  3  2  2           2  3                                             |     37  2.6|
      Acinus, Hyperplasia                  |                            3                                             |      3  2.3|
      Duct, Ectasia                        |    2           2     2  2  3                                             |     21  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +                                             |  50        |
      Head, Inflammation, Chronic Active   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  M  +  +  +  +     +  +  +                                             |  49        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1     |
      Cranium, Osteopetrosis               |                                                                          |      2  3.5|
      Femur, Fibrous Osteodystrophy        |                                                                          |      1     |
      Femur, Osteopetrosis                 |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Compression                          |       X                 X                                                |     11     |
      Gliosis                              |                                                                          |      1  3.0|
      Hemorrhage                           |                2                                                         |      5  2.2|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Lateral Ventricle, Hemorrhage        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +                                             |  50        |
      Congestion                           | 2              3           3                                             |      5  2.6|
      Hemorrhage                           |                2                                                         |      7  1.6|
      Infiltration Cellular, Lymphocyte    | 2     2  2  2  2     2  2  2                                             |     49  2.0|
      Pigmentation, Cholesterol            |       2                                                                  |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2     2  1  1  1     1  2  3                                             |     28  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Mineralization             |          1                                                               |      1  1.0|
      Arteriole, Mineralization            | 1              2     2     2                                             |     25  1.9|
      Interstitium, Inflammation, Chronic  |       2  1                                                               |     17  1.2|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                            3                                             |      1  3.0|
      Peribronchiolar, Inflammation, Acute |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +     +  +  +                                             |  49        |
      Lumen, Foreign Body                  |       2     2              3                                             |      4  2.5|
      Lumen, Hemorrhage                    | 2     2     1  2     2                                                   |     30  2.1|
      Mucosa, Inflammation, Acute          | 3     2  2  2        1     4                                             |     27  2.0|
      Nasolacrimal Duct, Hemorrhage        |          1                                                               |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      5  1.8|
      Olfactory Epithelium, Degeneration   | 2     2  2  2  1     2  2                                                |     44  2.0|
      Olfactory Epithelium, Erosion        |                                                                          |      2  2.0|
      Respiratory Epithelium, Degeneration |       1  1  1        2                                                   |     29  1.4|
      Respiratory Epithelium, Erosion      | 2           2                                                            |      4  2.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Atrophy                              |                                                                          |      1  4.0|
      Cataract                             |                                                                          |      3  3.7|
      Retina, Degeneration                 |                                                                          |      4  3.5|
      Sclera, Mineralization               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Inflammation, Acute                  |                         3                                                |      1  3.0|
      Nephropathy, Chronic                 | 2     3  4  2  1     2  3  4                                             |     49  2.4|
      Pelvis, Calculus Micro Observation   |                                                                          |            |
          Only                             |                                                                          |      1     |
      Renal Tubule, Cyst                   |                                                                          |      2     |
      Renal Tubule, Hyperplasia            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Pigmentation           | 2  3  2  2  1  2     2  3  2                                             |     49  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Acute                  |                3                 3                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Acute                  |                                  3                                       |             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Parasite Metazoan                    |          X                                         X  X                  |             
      Ulcer                                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Angiectasis                          |       2                                                                  |             
      Congestion                           |                                        2                                 |             
      Developmental Malformation           |                         X                             X                  |             
      Fatty Change                         |                                                                3         |             
      Focal Cellular Change                |       X  X  X  X     X  X     X     X  X     X  X  X  X  X  X  X  X      |             
      Granuloma                            |                      2  2                 2        2  2     2            |             
      Hematopoietic Cell Proliferation     |                         1                                                |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                  4                                       |             
      Bile Duct, Hyperplasia               | 2  2  1  2  1  1     1        1     2     1  1     1  2  3     1         |             
      Portal, Inflammation, Chronic        | 2  2  2  2  1  1     2  2     1     2  1  2  2  2  2  2  3  2  1  1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Fat, Necrosis                        |       4                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Acinus, Atrophy                      |       2     2        4  3           3  3     2           1  1            |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperkeratosis                       |    2                                                                     |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                | 4                                                              3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Acute                  |                                                                          |             
      Mucosa, Dilatation                   | 2  2  1     1  1     1        2  2        2           2  2  2  2  2      |             
      Mucosa, Erosion                      |    2                          2                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Pulp, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cardiomyopathy, Chronic              | 2  2  2  2  2  1     2  2     1  2  2  2  3  2  2  2  2  1  2  1  2      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Degeneration, Fatty                  |    1  2  2     2     4           2              1        2  1  1  3      |             
      Hematopoietic Cell Proliferation     |                                  1                                       |             
      Hemorrhage                           |                      4                                                   |             
      Hyperplasia                          | 2     2  2  2           2     2        2  2        1  2  2     2         |             
      Hypertrophy                          | 2                             2                       2  2               |             
      Pigmentation                         | 2  2  2  2  2  2     2  2     2  2  2  2  2  2  2  2  2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  M  +      |             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +     +  +     +  +  +  M  +  +  +  +  +  +  M  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Angiectasis           | 2                                   2                    3               |             
      Pars Distalis, Cyst                  |                               X  X  X        X     X        X            |             
      Pars Distalis, Hyperplasia           | 3                    3  3        3  3        3  2  3                     |             
      Pars Distalis, Metaplasia, Osseous   |                                                          2               |             
      Pars Intermedia, Angiectasis         |                                                       3                  |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          2     1     4  2     1  2           1  1  1     2  2     2      |             
      Follicle, Ectasia                    |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2  1                                2     2        2     1               |             
      Inflammation, Chronic Active         |          2           2  2     2        4     1        2           3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Ectasia                              |                                  2                                       |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
      Endometrium, Inflammation, Chronic   |                                                       2                  |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Myelofibrosis                        | 2                                                     2     2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2  2               |             
      Pigmentation                         |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    | 2  2  2  2  2        2  2           2  2  3  2  2  2  2  2  2  2         |             
      Mesenteric, Inflammation, Acute      |                                  3                                       |             
      Renal, Congestion                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |             2                       3                             2      |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2     2  2  2  2     3  2        2  2  2  2  2  2  2  2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Fibrosis                             |                      3                                                   |             
      Hematopoietic Cell Proliferation     | 1  4  3  3  3  2     2  2        4  2  3  1  3  2  2  4  4  3  2  2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation                         |    3  2  2  2  2     2  2     1  2  2  2  3  2  2  2  2  3  2  3  2      |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  M  +  M  +  +  +      |             
      Congestion                           |                                           4                              |             
      Cyst                                 |    X                                                                     |             
      Hyperplasia, Lymphoid                |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acinus, Ectasia                      | 2  2  4  2  2  2                 2  2  2     2  2  2  2        4         |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        | 2  3  3     2  3        2     2     2  3  2           2  2     3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Head, Inflammation, Chronic Active   |                                                                          |             
      Lip, Inflammation, Chronic Active    |                                     2                                    |             
      Subcutaneous Tissue, Head, Granuloma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Cranium, Osteopetrosis               |          4                                                               |             
      Femur, Osteopetrosis                 |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Compression                          |       X                                   X                              |             
      Hemorrhage                           |                      1                    2                       2      |             
      Hydrocephalus                        |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Congestion                           |                                           4                              |             
      Hemorrhage                           |       1                                   3           1     1            |             
      Infiltration Cellular                |                                                             2            |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2     2  2     2  2  2  2  2  2  2  2  2  2     2  2      |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1  2  2        1  1           1  2        2        1               |             
      Arteriole, Mineralization            |    2     2  2        2        2           2     2     1     2  2  2      |             
      Interstitium, Inflammation, Chronic  |          1           1                                   1               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Peribronchiolar, Inflammation, Acute |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          | 4           1                          1        1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Hemorrhage                    | 1  3  2  2  2  4     3           2  3  2     2     2  2  2  2  2         |             
      Mucosa, Inflammation, Acute          | 1     1  3  1           2        2  3  2  2  2  2  3  2  3  2  2  3      |             
      Mucosa, Inflammation                 |                      2                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                                                          |             
      Olfactory Epithelium, Degeneration   | 2  2  2  3  2  2     3  2     3  1  3  3  2  3  2  3  2  2  2  2  3      |             
      Olfactory Epithelium, Erosion        |                                  2     2     2     2              2      |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                   2      |             
      Respiratory Epithelium, Degeneration | 1  1  1  1  1  3     1  1     3     3  1  1  3  3  1  1  3  2  1  1      |             
      Respiratory Epithelium, Erosion      |       2                                                                  |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +                                                         |             
      Atrophy                              |                                                                          |             
      Cataract                             |       3                                                                  |             
      Hemorrhage                           |       3                                                                  |             
      Retina, Degeneration                 |       4        4                                                         |             
      Sclera, Mineralization               |                2                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Nephropathy, Chronic                 | 1  2  3  1  3  3     3  3     1  3  2  2  3  3  2  3  2  3  2  3  4      |             
      Pelvis, Calculus Micro Observation   |                                                                          |             
          Only                             |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Hypertrophy            |                                           2                              |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2     2  2     2  2  2  2  2  2  1  2  2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |          X                                   X                           |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Edema                                |                            3                                             |             
      Erosion                              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Edema                                |                            3                                             |             
      Ulcer                                |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Edema                                |                            3                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          | 3                 2                       2                       2      |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |          X                                                               |             
      Fatty Change                         |                                  1                             4         |             
      Focal Cellular Change                | X     X  X     X  X  X  X  X  X  X     X     X  X  X  X  X     X     X   |             
      Granuloma                            |                2              1  1                    2  2     3         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                              2                           |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2  2     2  2     2  2           2  1  2  2  2  2     1  2  2      |             
      Portal, Inflammation, Chronic        | 2  2  2  2     1  2  2  1  1     1     2  2  2  2  2  2  3  1  2     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Acinus, Atrophy                      | 3     4  2                    2  2        2     1  3  2  3  2     2      |             
      Acinus, Hyperplasia                  |                               2  2           2                       2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                           2                       3      |             
      Inflammation, Acute                  |                2                       4                       4         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                        4                       4  4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                        3                                 |             
      Mucosa, Dilatation                   |                1  1  1  2     2              2        2     2  2     2   |             
      Mucosa, Erosion                      |                                        2                             4   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
      Pulp, Inflammation, Chronic Active   |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy, Chronic              | 2  2  3  2     2  1  2  2  2  2  2     1  3  2  2  2  2  2  2  2  2  2   |             
      Atrium, Thrombosis                   |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Degeneration, Fatty                  | 2  2     1     2  2  1  2  2     2     2  2  1     1     2     2  1  1   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                            2  2  2           1     1     2           2   |             
      Hypertrophy                          |    1     2                                                     2         |             
      Pigmentation                         | 2  2  2  1     2  2  2  2  1  2  2     1  2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |    2                                               1              1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +  +     M  +  M  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |       X                          X              X                        |             
      Pars Distalis, Hyperplasia           | 3  2              2     3                 2  3                           |             
      Pars Distalis, Metaplasia, Osseous   |                                                                          |             
      Pars Intermedia, Angiectasis         |                                              3                           |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    2     1           2  1        2              1     1  2        2      |             
      Follicle, Ectasia                    |                         2                          2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |       2                                2                                 |             
      Inflammation, Chronic                | 2     2  2     2        1              2     1        2  1  2     2      |             
      Inflammation, Chronic Active         |    2                       2     3              2              2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Periovarian Tissue, Cyst             |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Ectasia                              |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                    3              2      |             
      Endometrium, Inflammation, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Myelofibrosis                        | 1                    1                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
      Mediastinal, Congestion              |       2                                                                  |             
      Mediastinal, Hyperplasia, Lymphoid   |       2                                                                  |             
      Mesenteric, Congestion               |       2           2              2                                       |             
      Mesenteric, Hyperplasia, Lymphoid    | 2     2  2           2  2  2  2  2                 2  2        2         |             
      Mesenteric, Inflammation, Acute      |                                                                          |             
      Renal, Congestion                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |    2  2                 2                          2                     |             
      Cyst                                 |                            X                                             |             
      Hyperplasia, Lymphoid                | 2     2  2     2  2  2  1  2  2  2     2  2  2  2  2  2  2     2     2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Fibrosis                             |          3                                                               |             
      Hematopoietic Cell Proliferation     | 2  2  2  3     2  3  2  3  2  2  2     2  1  2  2  2  2  4     2     3   |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Infarct                              |                                           4                              |             
      Pigmentation                         | 2     3  2     2  3  2  3  2  2  2     1     1  2  3  2     2  2     2   |             
      Capsule, Fibrosis                    |                                        3  3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  M  M  +  +  +   |             
      Congestion                           |                                                                          |             
      Cyst                                 |                X                                                         |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Acinus, Ectasia                      |    4  2        4  2  3  2  2     2           2     2  2  2  2  2     2   |             
      Acinus, Hyperplasia                  |                                  2                                       |             
      Duct, Ectasia                        | 2  2  2  3     2              2  2     2     2  2  3  2  3     4     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Head, Inflammation, Chronic Active   |                               3                                          |             
      Lip, Inflammation, Chronic Active    |                                                                          |             
      Subcutaneous Tissue, Head, Granuloma |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Compression                          |                            X           X           X           X         |             
      Hemorrhage                           |       1                                4                                 |             
      Hydrocephalus                        |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Congestion                           |       3                                            3                     |             
      Hemorrhage                           |    1                                               3              2      |             
      Infiltration Cellular                |                                                                          |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2     2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2   |             
      Metaplasia, Osseous                  |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2     1              2     1  2           2  1     1                  |             
      Arteriole, Mineralization            | 2  2  2  2     2  2  2     2           2  2  2  1  2     2     2     1   |             
      Interstitium, Inflammation, Chronic  |          1        1              1              1              1         |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                       1  2               |             
      Peribronchiolar, Inflammation, Acute |                                        1                                 |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Lumen, Foreign Body                  |                         2                                                |             
      Lumen, Hemorrhage                    |    2  2  2              2  1     1     3        2     2  1  2  2  2  2   |             
      Mucosa, Inflammation, Acute          | 2     2  2     2  2  3  2  2  2  2     2  2  2  3  2  3  2  2        2   |             
      Mucosa, Inflammation                 |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                        1                          2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                              2                           |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2     2  2  3  2     2  2     2  2  3  2  2  2  2  2  2  2  3   |             
      Olfactory Epithelium, Erosion        |                      2                       1                       2   |             
      Olfactory Epithelium, Metaplasia     |          2                                                               |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Degeneration | 2  1     1     1  1  1  3     2  1     1  2  1  1  2  3  1  1  1  1  3   |             
      Respiratory Epithelium, Erosion      |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                      +                  |             
      Atrophy                              |                                                       4                  |             
      Cataract                             |                3                                                         |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                4                                                         |             
      Sclera, Mineralization               |                3                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Nephropathy, Chronic                 | 2  1  2  3     3  2  3  2  2  3  3     3  2  3  3  2  4  2  2  4  3  4   |             
      Pelvis, Calculus Micro Observation   |                                                                          |             
          Only                             |                         X                                                |             
      Renal Tubule, Hyperplasia            |                1                                                         |             
      Renal Tubule, Hypertrophy            |                                                                          |             
      Renal Tubule, Pigmentation           | 2  2  2  2     2  2  2  2  1  1  2     2  2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +     +     +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +     +     +     +  +                                             |  49        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +     +     +     +  +                                             |  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +     +     +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      5     |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +     +     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +     +     +     +  +                                             |  49        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +     +     +     +  +                                             |  49        |
      Edema                                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +     +     +     +  +                                             |  49        |
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +     +     +  +                                             |  50        |
      Angiectasis                          |                   2                                                      |      6  2.2|
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                         X  X                                             |      5     |
      Fatty Change                         |                                                                          |      3  2.7|
      Focal Cellular Change                |    X  X     X     X     X  1                                             |     41  1.0|
      Granuloma                            |                   2                                                      |     13  1.9|
      Hematopoietic Cell Proliferation     |                   1                                                      |      2  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia               |    1  1     3     2     1                                                |     36  1.7|
      Portal, Inflammation, Chronic        |    2  2     2     2     2  2                                             |     46  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | M  +  +     +     +     +  +                                             |  49        |
      Acinus, Atrophy                      |    2                    2  2                                             |     24  2.3|
      Acinus, Hyperplasia                  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +     +     +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +     +     +  +                                             |  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      2  2.5|
      Inflammation, Acute                  |                                                                          |      3  3.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      5  3.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +     +     +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mucosa, Dilatation                   |             2     2                                                      |     26  1.7|
      Mucosa, Erosion                      |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Pulp, Inflammation, Chronic Active   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +     +     +  +                                             |  50        |
      Cardiomyopathy, Chronic              | 2  1  3     2     2     2  3                                             |     50  2.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     M     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     M     +     +  +                                             |  49        |
      Degeneration, Fatty                  |    3  1                 1                                                |     31  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |     19  1.8|
      Hypertrophy                          |                         2  2                                             |      9  1.9|
      Pigmentation                         |    2  2           2     2  2                                             |     48  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     M     +     +  +                                             |  48        |
      Hyperplasia                          |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | M  +  +     +     +     +  +                                             |  49        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +     M     +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +     +     +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.3|
      Pars Distalis, Cyst                  |       X     X     X     X  X                                             |     14     |
      Pars Distalis, Hyperplasia           |       2           3     2                                                |     17  2.6|
      Pars Distalis, Metaplasia, Osseous   |                                                                          |      1  2.0|
      Pars Intermedia, Angiectasis         |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Nervosa, Cyst                   |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +     +     +  +                                             |  50        |
      Ultimobranchial Cyst                 |                         X                                                |      1     |
      C-Cell, Hyperplasia                  |    1              2                                                      |     23  1.7|
      Follicle, Ectasia                    |                         3                                                |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +     +     +     +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Chronic                |    2                    1  2                                             |     20  1.7|
      Inflammation, Chronic Active         |                   2                                                      |     14  2.2|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +     +     +  +                                             |  50        |
      Periovarian Tissue, Cyst             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +     +     +  +                                             |  50        |
      Ectasia                              |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  2.5|
      Endometrium, Inflammation, Chronic   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |             +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +     +     +  +                                             |  50        |
      Myelofibrosis                        |    2        1     2        1                                             |      9  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +     +     +  +                                             |  50        |
      Congestion                           |       2                                                                  |      1  2.0|
      Hyperplasia, Lymphoid                |                            2                                             |      3  2.0|
      Pigmentation                         |       2                                                                  |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      3  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |    2              3     2  2                                             |     32  2.1|
      Mesenteric, Inflammation, Acute      |                                                                          |      1  3.0|
      Renal, Congestion                    | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M     +     +     +  +                                             |  48        |
      Congestion                           |             2                                                            |      8  2.1|
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |    3              3     2  2                                             |     42  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +     +     +  +                                             |  50        |
      Fibrosis                             |             4                                                            |      3  3.3|
      Hematopoietic Cell Proliferation     |    3  2     2     3     3  3                                             |     46  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Pigmentation                         | 2  2        2     2     2  1                                             |     44  2.1|
      Capsule, Fibrosis                    |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +     +     +  +                                             |  46        |
      Congestion                           |       3                                                                  |      2  3.5|
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Lymphoid                |                            2                                             |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +     +     +  +                                             |  50        |
      Acinus, Ectasia                      |    1  3           2     2  4                                             |     34  2.3|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Ectasia                        |    2  3                    2                                             |     31  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +     +     +  +                                             |  50        |
      Head, Inflammation, Chronic Active   |                                                                          |      1  3.0|
      Lip, Inflammation, Chronic Active    |                                                                          |      1  2.0|
      Subcutaneous Tissue, Head, Granuloma |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +     +     +  +                                             |  50        |
      Cranium, Osteopetrosis               |                                                                          |      1  4.0|
      Femur, Osteopetrosis                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +     +     +  +                                             |  50        |
      Compression                          |                                                                          |      6     |
      Hemorrhage                           |                            1                                             |      6  1.8|
      Hydrocephalus                        |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +     +     +  +                                             |  50        |
      Congestion                           | 1                          2                                             |      5  2.6|
      Hemorrhage                           |                                                                          |      7  1.7|
      Infiltration Cellular                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Lymphocyte    | 2  2  2     2     2     2  2                                             |     49  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             2           2  2                                             |     20  1.6|
      Arteriole, Mineralization            | 2  2              2                                                      |     30  1.9|
      Interstitium, Inflammation, Chronic  |                            2                                             |      9  1.1|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      2  1.5|
      Peribronchiolar, Inflammation, Acute |                                                                          |      1  1.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                         1                                                |      5  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +     +     +  +                                             |  50        |
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
      Lumen, Hemorrhage                    |    2        2     2        4                                             |     34  2.1|
      Mucosa, Inflammation, Acute          |    2        1     2     2  2                                             |     41  2.1|
      Mucosa, Inflammation                 |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   | 2  3        3     2     2  3                                             |     48  2.3|
      Olfactory Epithelium, Erosion        |    2        2              2                                             |     11  1.9|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Respiratory Epithelium, Degeneration |    1        1     1     1  1                                             |     45  1.5|
      Respiratory Epithelium, Erosion      |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +     +     +  +                                             |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Atrophy                              |                                                                          |      1  4.0|
      Cataract                             |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      3  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Sclera, Mineralization               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +     +     +  +                                             |  50        |
      Nephropathy, Chronic                 |    3        2     3     2  3                                             |     48  2.6|
      Pelvis, Calculus Micro Observation   |                                                                          |            |
          Only                             |                                                                          |      1     |
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Hypertrophy            |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           | 1  2  2     2     2     2  2                                             |     50  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +     +     +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |    2                             1                    2                  |             
      Developmental Malformation           |       X                                         X                        |             
      Fatty Change                         |          1                                   2                           |             
      Focal Cellular Change                |    1  X  X  X              X  X  X  X  X        X  X  X        X  X  X  X|             
      Granuloma                            |             2                    2                                   2   |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Bile Duct, Hyperplasia               |    2  1  1                             1     2  1  1  2           2  2  2|             
      Portal, Hyperplasia                  |                                                                2         |             
      Portal, Inflammation, Chronic        |    2                    2  2  1     1  1     1  2  2  2  1     1  2  2  2|             
      Portal, Inflammation, Chronic Active |             2                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                               1  2  2           2              2        2|             
      Acinus, Vacuolization Cytoplasmic    |                                              2                           |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                         2|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Squamous                |                                              3                           |             
      Inflammation, Chronic Active         |    3                                                              2      |             
      Ulcer                                |    3        3           4                    4           4               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |    2                                            2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Dilatation                   |    2     2                 1  2  2  2  2     2        1  2     1         |             
      Mucosa, Erosion                      |             3                                1                           |             
      Mucosa, Mineralization               |             2                                                            |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Pulp, Inflammation, Chronic          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Aorta, Mineralization                |             4                                                            |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Cardiomyopathy, Chronic              | 1  1  2  1  3           2  2  3  2  2  2     2  2  1  3  3     3  2  2  2|             
      Mineralization                       |             4                                                            |             
      Artery, Mineralization               |             4                                                            |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +        +  +  +  +  M  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +        +  +  +  +  M  +     +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                          3               |             
      Degeneration, Fatty                  | 1     2  1  3           2  2     2     2     2  1        3     2  2  1  2|             
      Hyperplasia                          | 2                          2  1                       2        1  1      |             
      Hypertrophy                          |             2                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation                         | 2  1  2  2  2           2  2  2  2     2     2  2  2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +        +  +  +  +  M  +     +  +  +  +  +     +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2           2                                                           2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +        +  +  +  +  +  +     +  +  M  +  +     +  +  +  M|             
      Hypertrophy                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           | 3                                                                        |             
      Pars Distalis, Congestion            |                2                                                         |             
      Pars Distalis, Cyst                  |                               X     X           X  X                    X|             
      Pars Distalis, Hemorrhage            |                                        4                                 |             
      Pars Distalis, Hyperplasia           |       3                             2                                   2|             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       2                       2  2  1        1                 1  2     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
      Inflammation, Acute                  |                            4                                             |             
      Inflammation, Chronic                | 1  2  2                       2  1  2  2     2     2  2  1     1        2|             
      Inflammation, Chronic Active         |                                                                   2  3   |             
      Duct, Ectasia                        |    4                                                                     |             
      Duct, Hyperplasia, Squamous          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Ectasia                              |                                                                          |             
      Endometrium, Ectasia                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                                   2  1   |             
      Endometrium, Inflammation, Chronic   |                            2                                             |             
      Myometrium, Inflammation, Chronic    |                            2                                             |             
                                            __________________________________________________________________________|             
   Vagina                                  |             +                                            +               |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Congestion                           |                               2                                          |             
      Hyperplasia, Lymphoid                | 2     2                       2     3                                    |             
      Inflammation, Acute                  |                                     4                                    |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                       2                  |             
      Mediastinal, Pigmentation            |                                                       2                  |             
      Mesenteric, Congestion               |    2        2                                                           2|             
      Mesenteric, Hyperplasia, Lymphoid    | 2  2  2  2                 2  2  1  2  2     2     2  2        2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +        M  +  +  +  +  +     +  +  M  +  +     +  +  +  +|             
      Congestion                           |                2                                                        2|             
      Cyst                                 |       X     X                                                            |             
      Hyperplasia, Lymphoid                | 2  2  2     2              2  2  2  2  2     1  2     2  2     2  2  2  2|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Fibrosis                             |                                                 2        3               |             
      Hematopoietic Cell Proliferation     | 3        2  2              2  2  2  3  2     1  3  2  2  1     3  2  3  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                          |             
      Pigmentation                         | 2  2  2  2  1              2  2  2  2  2     2  2  2  2  2     2  3  3  3|             
      Capsule, Inflammation, Acute         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                2                                                         |             
      Cyst                                 |       X     X                                      X                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Ectasia                      | 3  4                          2  3     4        2     3  4     3  3  2  2|             
      Acinus, Hyperplasia, Cystic          |                                                                          |             
      Duct, Ectasia                        |    4  2  2  2              2                 2  2     3                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Cyst Epithelial Inclusion            |          X                                                               |             
      Head, Ulcer                          |             3                                                            |             
      Subcutaneous Tissue, Abscess         | 4                                                                        |             
      Subcutaneous Tissue, Head, Abscess   |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |             4                                                            |             
      Femur, Fibrous Osteodystrophy        |             4                                X                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Compression                          |    X     X                             X     X        X  X           X   |             
      Hemorrhage                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Congestion                           |    2           2                                         3               |             
      Hemorrhage                           |                                              1           2               |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2  2  2        2  2  2  2  2  2     2  2  2  2  2     2  2  2  2|             
      Pigmentation, Cholesterol            |                                                       1                  |             
      Alveolar Epithelium, Hyperplasia     |                            3                                             |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2     1  2                 2     1  1  1     2     2  2  2     1  2      |             
      Arteriole, Mineralization            | 2  2        2           2  2                       2     2        2  2  2|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                  2                    2                  |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          | 2                                                                        |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Pleura, Fibrosis                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Smooth Muscle, Hyperplasia           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Glands, Hyperplasia                  |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Hemorrhage                    | 2  2  1                 3     2  3  1  2        3  2              2  3  2|             
      Mucosa, Inflammation, Acute          | 2  2  2  1                    3  3  1  3     3  3  1  1        2  2     2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 2                                               2                        |             
      Olfactory Epithelium, Degeneration   | 2  2  3  2  2              2  2  2  2  2     2  3  2  2  2     3  3  3  2|             
      Olfactory Epithelium, Erosion        |                               2  2     2     1  2     2                  |             
      Olfactory Epithelium, Hemorrhage     |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                  2                                       |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                       2                  |             
      Respiratory Epithelium, Degeneration | 1  2  1  1                 1  2  2  2        2  3  1  1        1  3  2  2|             
      Respiratory Epithelium, Erosion      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                 +                           |             
      Cataract                             |                            3                                             |             
      Anterior Chamber, Hemorrhage         |                            3                                             |             
      Lids, Inflammation, Chronic Active   |                                              2                           |             
      Retina, Degeneration                 |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 1  3  4  2  4           2  2  3  3  2  4     4  3  2  4  4     4  2  2  3|             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Pigmentation           | 1  2  2  2  1           2  2  2  2  2  1     2  2  2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Ulcer                                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Erosion                              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Developmental Malformation           |             X                                                  X         |             
      Fatty Change                         |                                                                          |             
      Focal Cellular Change                | X     X     X  X     X  X  X  X  X  X        X  X     X  X  X  X     X  X|             
      Granuloma                            |                      2                                2  1  2        2   |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hemorrhage                           |                                                                         3|             
      Bile Duct, Hyperplasia               | 2     2        2     2  3  2        2     2  2  1     2     1  2     2  1|             
      Portal, Hyperplasia                  |                                                                          |             
      Portal, Inflammation, Chronic        | 1     2     1  1     2  3  2  1  1  2     2  2        2  2  1  2     2  1|             
      Portal, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      | 1     2        2        2           2        2                       2   |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
      Arteriole, Inflammation, Chronic     |       3                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                              4                           |             
      Inflammation, Chronic Active         |                                           3                              |             
      Ulcer                                |                                           4  4  4                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Dilatation                   | 2     2     2  2     2  2  2  2  2        2     2     2           2     1|             
      Mucosa, Erosion                      |                                                 1                        |             
      Mucosa, Mineralization               |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Pulp, Inflammation, Chronic          |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 1     2        2     2  2  2  3  2  2     2  1  2     2  3  2  3     2  1|             
      Mineralization                       |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  | 1     1     1  2     3  1           2     1     4     2  1  1     2     1|             
      Hyperplasia                          |             1                 2                                         1|             
      Hypertrophy                          |                2              1                                          |             
      Inflammation, Chronic                |                                                 2                        |             
      Pigmentation                         | 2     2     2  2     2  2  2  2  2  2     2  2  2     2  2  1  2  2  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hyperplasia                          |       2                                         3                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     +  +     +  +  M  M  +  M     +  +  M     M  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  | X              X        X  X                                             |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |       3                             2                       3            |             
      Pars Intermedia, Angiectasis         |                                                                   4      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |       X                                      X                           |             
      C-Cell, Hyperplasia                  | 2                    1           1           2  2                    1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M     M     +  +     +  +  M  M  +  +     +  +  +     +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                              4                           |             
      Inflammation, Chronic                |             1           1           1        2           1     2         |             
      Inflammation, Chronic Active         |                      2                    2           1                  |             
      Duct, Ectasia                        |                                                                          |             
      Duct, Hyperplasia, Squamous          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                              X                           |             
      Periovarian Tissue, Cyst             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Endometrium, Ectasia                 | 2                                                                        |             
      Endometrium, Hyperplasia, Cystic     |                                              2  4     1        2         |             
      Endometrium, Inflammation, Chronic   |                                                                          |             
      Myometrium, Inflammation, Chronic    |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                           +                              |             
      Inflammation, Acute                  |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     4                                    |             
      Myelofibrosis                        |                         1                                            1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2                                         2              2              2|             
      Inflammation, Acute                  |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                            2                                             |             
      Mediastinal, Pigmentation            |                                                                          |             
      Mesenteric, Congestion               |                                                          2               |             
      Mesenteric, Hyperplasia, Lymphoid    | 2     1              2  2  3  2                             2  2     2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     M     +  M     +  +  +  +  +  +     +  M  +     +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |             2        2  1  2  2  2  2     2     2     2  2  2  1     2  2|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 3                        |             
      Hematopoietic Cell Proliferation     | 3     2     2  2     2  2  2  2  2  4     1  2  3     1  2  2  2     2  2|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Infarct                              |                3                                                         |             
      Pigmentation                         | 2     2     2  2     2  2  2  2  2  1     4  2  1     2  2  2  2  2  2  2|             
      Capsule, Inflammation, Acute         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  M  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Ectasia                      |       4     2  3           2  3  3  2           4           2  2     2  2|             
      Acinus, Hyperplasia, Cystic          |                                                                          |             
      Duct, Ectasia                        |       3        3     2     2              3  2  4        3     2  2     2|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Head, Ulcer                          |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Head, Abscess   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                                 X                        |             
      Femur, Fibrous Osteodystrophy        |       2                                         X                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +     +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Compression                          |                      X        X              X           X               |             
      Hemorrhage                           |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Congestion                           |                                                                3        2|             
      Hemorrhage                           |                3                                                         |             
      Infiltration Cellular, Lymphocyte    | 2     2     2  2     2  2  3  2  2  2     2  2  2     2  2  2  2  2  2  2|             
      Pigmentation, Cholesterol            |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia     |                            3                                             |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1           1        1  1  2  2  1  1     2  2  3     1  1  1  1  2     2|             
      Arteriole, Mineralization            | 2           2        2  2     1  2  2     2     2        2     2     2  1|             
      Interstitium, Inflammation, Chronic  |                                  1                                       |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |             1                                            1               |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                            4                                             |             
      Pleura, Fibrosis                     |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Smooth Muscle, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Glands, Hyperplasia                  |                               4                                          |             
      Lumen, Foreign Body                  |                                  2                                       |             
      Lumen, Hemorrhage                    | 2              3        2        2        2  2        2  3  2     1  2  2|             
      Mucosa, Inflammation, Acute          | 1     2     2  2     2  2  2  2  3  2        2        2  2  2  2  1  2  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                      3                    2                              |             
      Olfactory Epithelium, Degeneration   | 1     2     2        2  2  2  2  2  2     2  2  2     2  3  3  2  2  3  2|             
      Olfactory Epithelium, Erosion        |                      1                                                   |             
      Olfactory Epithelium, Hemorrhage     |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                  2                    2                  |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Degeneration |       1     1        1  1  1  1     1     1  2        1  3  2     2  2  1|             
      Respiratory Epithelium, Erosion      |       2                          3                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Lids, Inflammation, Chronic Active   |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 1     4     2  2     2  2  1  3  3  2     3  3  4     4  4  2  3  2  2  1|             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Renal Tubule, Cyst                   |                               X                                          |             
      Renal Tubule, Pigmentation           | 1     2     2  1     2  2  1  2  1        2  2  2     1  1  2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                         2|             
      Inflammation, Chronic                |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +                                             |  48        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Erosion                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |             2  2           1                                             |      6  1.7|
      Developmental Malformation           |                         X                                                |      5     |
      Fatty Change                         |                                                                          |      2  1.5|
      Focal Cellular Change                |       X     X  X  X  X  X  X                                             |     41  1.0|
      Granuloma                            |                         2  2                                             |     10  1.9|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |             1  2     2  2  2                                             |     31  1.7|
      Portal, Hyperplasia                  |                                                                          |      1  2.0|
      Portal, Inflammation, Chronic        |          1  1  2  1  2  2  2                                             |     40  1.6|
      Portal, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   2        |
      Fat, Necrosis                        |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
      Acinus, Atrophy                      |                      2     2                                             |     15  1.9|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  2.0|
      Arteriole, Inflammation, Chronic     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Squamous                |    3     3                                                               |      4  3.3|
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |    4                                                                     |      9  3.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Foreign Body                         |          3                                                               |      1  3.0|
      Inflammation, Acute                  |                            2                                             |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Mucosa, Dilatation                   |    2  2     2                                                            |     28  1.9|
      Mucosa, Erosion                      |    2           2                                                         |      5  1.8|
      Mucosa, Mineralization               |                                                                          |      1  2.0|
      Serosa, Inflammation, Chronic Active |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   2        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |             3                                                            |      1  3.0|
      Pulp, Inflammation, Chronic          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              |    2  2  3  2  2  3  2  2  1                                             |     47  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Fatty                  |    2  2  2  3  1     2  3  1                                             |     37  1.8|
      Hyperplasia                          |                                                                          |      9  1.4|
      Hypertrophy                          |                            2                                             |      4  1.8|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Pigmentation                         |    2  2  2  2  2  2  2  2  2                                             |     48  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |             1                                                            |      6  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M  M  +  +  +  +  +  +                                             |  41        |
      Hypertrophy                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Congestion            |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |    X     X                                                               |     11     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                            2                                             |      7  2.4|
      Pars Intermedia, Angiectasis         |       2                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |    2                                                                     |     15  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +                                             |  44        |
      Hyperplasia                          |                         3                                                |      2  3.0|
      Inflammation, Acute                  |                                                                          |      2  4.0|
      Inflammation, Chronic                |                   1  2                                                   |     21  1.6|
      Inflammation, Chronic Active         |          2                 1                                             |      7  1.9|
      Duct, Ectasia                        |                                                                          |      1  4.0|
      Duct, Hyperplasia, Squamous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Ectasia                              |                         2                                                |      1  2.0|
      Endometrium, Ectasia                 |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                   1                                                      |      7  1.9|
      Endometrium, Inflammation, Chronic   |                                                                          |      1  2.0|
      Myometrium, Inflammation, Chronic    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Myelofibrosis                        |             1                                                            |      4  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |             2           2                                                |     10  2.1|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      4  2.0|
      Mesenteric, Hyperplasia, Lymphoid    |       1  2                 2                                             |     29  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  M  +  +  +  +                                             |  42        |
      Congestion                           |                                                                          |      3  2.0|
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Lymphoid                |    2  2     3     2  2  2  2                                             |     39  1.9|
      Inflammation, Acute                  |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      3  2.7|
      Hematopoietic Cell Proliferation     |    2  2  2  3     2  2  1  2                                             |     44  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Pigmentation                         |       2  2  1  4  1  2  1  2                                             |     47  2.0|
      Capsule, Inflammation, Acute         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +  +  +  +  +                                             |  46        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      3     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
      Acinus, Ectasia                      |          2        4  2                                                   |     27  2.7|
      Acinus, Hyperplasia, Cystic          |                   4                                                      |      1  4.0|
      Duct, Ectasia                        |    2           1     3  2                                                |     23  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Head, Ulcer                          |                                                                          |      1  3.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  4.0|
      Subcutaneous Tissue, Head, Abscess   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      2  4.0|
      Femur, Fibrous Osteodystrophy        |                                                                          |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Compression                          |                X     X                                                   |     13     |
      Hemorrhage                           |    2                                                                     |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                1                                                         |      6  2.2|
      Hemorrhage                           |             1                                                            |      4  1.8|
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2  2  2  2  2                                             |     50  2.0|
      Pigmentation, Cholesterol            |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          2  2     1  2  1  2                                             |     36  1.6|
      Arteriole, Mineralization            |    2  2              2                                                   |     26  1.9|
      Interstitium, Inflammation, Chronic  |                            1                                             |      2  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      4  1.5|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  4.0|
      Pleura, Fibrosis                     |                                                                          |      1  4.0|
      Smooth Muscle, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Glands, Hyperplasia                  |                                                                          |      1  4.0|
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
      Lumen, Hemorrhage                    |       2  3  2     1  2  2  2                                             |     32  2.1|
      Mucosa, Inflammation, Acute          |    1  2  2  2     2  2  2  2                                             |     41  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |          2     1                                                         |      6  2.0|
      Olfactory Epithelium, Degeneration   |    2  3  2  2  2  2  2  2  2                                             |     47  2.2|
      Olfactory Epithelium, Erosion        |                   1  2  2                                                |     10  1.7|
      Olfactory Epithelium, Hemorrhage     |    2                                                                     |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                         2  1                                             |      5  1.8|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Respiratory Epithelium, Degeneration |       2  1  1  1  1  3  2  1                                             |     39  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Erosion      |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   3        |
      Cataract                             |                         2                                                |      2  2.5|
      Anterior Chamber, Hemorrhage         |                                                                          |      1  3.0|
      Lids, Inflammation, Chronic Active   |                                                                          |      1  2.0|
      Retina, Degeneration                 |                         4                                                |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Hydronephrosis                       |                4                                                         |      1  4.0|
      Nephropathy, Chronic                 |    2  3  3  4  3  4  3  2  4                                             |     49  2.8|
      Capsule, Inflammation, Chronic       |                      2                                                   |      1  2.0|
      Renal Tubule, Cyst                   |                                                                          |      1     |
      Renal Tubule, Pigmentation           |    2  2  2  1  2  2  2  2  1                                             |     48  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                2                                                         |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Ulcer                                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |                                     2        2     1                     |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                           X                              |             
      Fatty Change                         |                                              2                           |             
      Focal Cellular Change                |    X  X  X  X  X              X  X  X     X        X        X           X|             
      Granuloma                            |                                                                          |             
      Necrosis                             |                                        3                                 |             
      Bile Duct, Hyperplasia               |    2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  3     3  2  2|             
      Portal, Inflammation, Chronic        |    2  2  2  1  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2     2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Necrosis                        |                                                                   4      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Acinus, Atrophy                      |    1     2  2              2     2  2     2     3  2  2  2  1           3|             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              |                                                                   3      |             
      Hyperplasia, Squamous                |    2                                               2                     |             
      Inflammation, Acute                  |                            2                                      3      |             
      Inflammation, Chronic Active         |    2                                3                                    |             
      Ulcer                                |                                     4        4                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                   3      |             
      Mucosa, Dilatation                   |                            2  2     2        1        2     1     2  2   |             
      Mucosa, Ectasia                      |             2        2                                                   |             
      Mucosa, Erosion                      |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Ulcer                        |                                     4                    2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cardiomyopathy, Chronic              |    2  2  2  2  2  2  2  2  2  3  2  3  2  2  2  3  2  2  3  3     3  1  3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Degeneration, Fatty                  |       1     2  2  2  2     2  2  2  2  2     3     2  1  2        3  2   |             
      Hyperplasia                          |    2  1     1                       2     1  2     2  2     2            |             
      Hypertrophy                          |          1                 2                       2                     |             
      Pigmentation                         |       2  1  1  1  1  1  2     1  1  2     1  2  2  1  1  2  1     2  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                         2     2                          2              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +     +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Atrophy               |                                                                          |             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Hemorrhage            |                                                          4               |             
      Pars Distalis, Hyperplasia           |    2  2  1  2  3                 1  2  2           2              3      |             
      Pars Intermedia, Cyst                |             X           X                                                |             
      Pars Nervosa, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                       2                  |             
      Ultimobranchial Cyst                 |                                     X                                    |             
      C-Cell, Hyperplasia                  |       2     2                    3  1                    1  3           2|             
      Follicle, Ectasia                    |       2                             3                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Abscess                              |             3           3              4                                 |             
      Inflammation, Acute                  |                                              4                           |             
      Inflammation, Chronic                |    2  2        2  1     2     1  2  2              2  2     2           2|             
      Inflammation, Chronic Active         |          3                                2                              |             
      Duct, Ectasia                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |       2                                                                  |             
      Hyperplasia                          |                                  2                    2     2            |             
      Inflammation, Acute                  |                                        3     4                       2   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |    2           2        1     2     3                       2           3|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |    2                    2              3                    2            |             
      Interstitial Cell, Hyperplasia       |    2  2  2  3  2  2     2  2  2  2  2                 2  2  2     2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +        +                 +                                 |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Myelofibrosis                        |                               3                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Edema                                |                                           2                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinal, Congestion              |                         2                                                |             
      Mesenteric, Congestion               |                         1                                                |             
      Mesenteric, Hyperplasia, Lymphoid    |             2  2                    1        2  2  2     2           2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  M  +  +  M  +     +  M  +|             
      Congestion                           |          2           2  3     3  2        2                              |             
      Cyst                                 |                                           X                              |             
      Hyperplasia, Lymphoid                |    2  2  2  2  2  2  2  2        2  2              2  2     2           2|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis                             |                                     3                                    |             
      Hematopoietic Cell Proliferation     |    2  2  2  3  2  2  2  2  2  2  2  2  3  3  2     2  3  2  2     2  2  2|             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |    2  2  2  3  2  2  2  2     2  2  2     2  3  2  2  2  2  2     1  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
      Congestion                           |                                        3                                 |             
      Cyst                                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                      2   |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Ectasia                      |       2  2  2        1     2        3        4  2  2  2  2  1        3  2|             
      Duct, Ectasia                        |                            2                    2        2               |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cyst Epithelial Inclusion            |                                           X                              |             
      Epidermis, Cyst                      |                      3                                                   |             
      Hair Follicle, Head, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hair Follicle, Head, Inflammation,   |                                                                          |             
           Acute                           |                                                             2            |             
      Head, Inflammation, Acute            |                                                                          |             
      Head, Inflammation, Chronic Active   |                                                                          |             
      Tail, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                     3                                    |             
      Femur, Fibrous Osteodystrophy        |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Compression                          |                                                                      X   |             
      Hemorrhage                           |                            3                    3        2           2   |             
      Necrosis                             |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion                           |    2                                            3                        |             
      Hemorrhage                           |                                                 3           1            |             
      Infiltration Cellular, Lymphocyte    |    2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2     2  2  2|             
      Pigmentation, Cholesterol            |       1                                                                  |             
      Alveolar Epithelium, Hyperplasia     |                         2                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       2  2  2     2  2  2     2  2  2              1  1  1  2        1  1|             
      Arteriole, Mineralization            |    2     2  1  1  2  2  2  2  2  2  2     2     2  2  2  2  2     1     2|             
      Bronchiole, Mineralization           |          1                                                               |             
      Interstitium, Inflammation, Chronic  |       2           2                                                  1   |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |    1                 1                                      1            |             
      Pleura, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Hemorrhage                    |    3  3  2  2  2  2  2  2  2  3  3  4        2     2     4  2     2     3|             
      Mucosa, Inflammation, Acute          |    2  2  2  1     1           2           2     1     2  2           2  2|             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |             1                                3           2               |             
      Nasolacrimal Duct, Inflammation      |    2                                                                     |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                            2                                             |             
      Olfactory Epithelium, Degeneration   |    2     2  2  2  1  1  2     2  2  1     2     2  2  2  2  2     2     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Degeneration |    2     2  2  1        1     3  1                    2     1     2      |             
      Respiratory Epithelium, Erosion      |                                                          2               |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                               4                                          |             
      Retina, Degeneration                 |                               4                                          |             
      Sclera, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
      Nephropathy, Chronic                 |    3  3  2  2  2  4  2  2  2  3  2  4     2  4  2  3  2  4  2     4  3  3|             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                   1      |             
      Renal Tubule, Pigmentation           |    2  2  2  1  2  2  2  2  2  2  2  2  1  1  2  2  1  2  2  2     2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Inflammation, Acute                  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Parasite Metazoan                    |             X                                         X                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Angiectasis                          |             2     2                                   3                  |             
      Congestion                           |                3                       3                       2         |             
      Developmental Malformation           |                                                                          |             
      Fatty Change                         |                            3                                             |             
      Focal Cellular Change                |          X  X        X  X           X     X     X  X  X     X            |             
      Granuloma                            |                                                             2            |             
      Necrosis                             |                2                                                         |             
      Bile Duct, Hyperplasia               |    3        2  2  2  2  2  2     2  2  2  2     2  2  2     3  1  2  4   |             
      Portal, Inflammation, Chronic        |    2     2  2  1  2  2  2  2        2  2  2     2  2  2     2  1  2  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Acinus, Atrophy                      |    2              4     4        4  4  3  4     3  2  2     1  1     3   |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Cyst                                 |                         X                                                |             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |    3                                                                 2   |             
      Inflammation, Chronic Active         |                            3                                             |             
      Ulcer                                |                      3     4                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Mucosa, Dilatation                   |                      2     2     2                    2              1   |             
      Mucosa, Ectasia                      |                                                                          |             
      Mucosa, Erosion                      |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Ulcer                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Cardiomyopathy, Chronic              |    2     3  3  2  2  2  3  3     3  3  3  3     3  3  3     3  4  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Degeneration, Fatty                  |    2     2     2  1  2     2     2  2     2     1  2           2  3  2   |             
      Hyperplasia                          |             2                       2                          2         |             
      Hypertrophy                          |                                                                          |             
      Pigmentation                         |    2     1  2  2  2  2  1  2     2        2     2  1  1        2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Hyperplasia                          |                         1           2     2        2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Hyperplasia                          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +  M  +  +  +  M     +  +  M  +     +  +  +     +  +  M  +   |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Pars Distalis, Atrophy               |                                           2                              |             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2        2                    2     3        2   |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Nervosa, Pigmentation           |                                           3                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                   1        1     2                 1                     |             
      Follicle, Ectasia                    |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    2     2  2  2  2  2              2  2  2           2     2  2  2      |             
      Inflammation, Chronic Active         |                         2  2     2                                   3   |             
      Duct, Ectasia                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |                   2     2           2                       3            |             
      Inflammation, Acute                  |    2                                            2                        |             
      Inflammation, Chronic                |                                           4                              |             
      Inflammation, Chronic Active         |          3              3              3                       3     3   |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Atrophy                              |          2                 3        1     3        2        3            |             
      Interstitial Cell, Hyperplasia       |    2     2  2  1  2  2  2  1     2              2     2        2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Myelofibrosis                        |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Mediastinal, Congestion              |                                                                          |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |          2        2  2     1           2  2     2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M     +  +  M  +  +  M  +     M  +  +  +     M  +  +     +  M  M  +   |             
      Congestion                           |             2                       2              2                     |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |          2  2     1  2     3        2  2  2        2  2     2            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Fibrosis                             |    3                                                           3         |             
      Hematopoietic Cell Proliferation     |          2  2  1  2  2  3  3     2     2  2        2  2     2  2  2      |             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Mineralization                       |                         2                                                |             
      Pigmentation                         |    2     2  2        3     2        2  2  2     2  2  2     2  2     1   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +  +  +  +  +  M     +  +  M  +     +  +  +     +  +  +  +   |             
      Congestion                           |                                                 2                        |             
      Cyst                                 |    X     X                                X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Inflammation, Acute                  |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Ectasia                      |    2     3  4        4  3  3     2  2  2        2  2  2     2  3     2   |             
      Duct, Ectasia                        |                   1  2     3           2        2  2                     |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Epidermis, Cyst                      |                                                                          |             
      Hair Follicle, Head, Hemorrhage      |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hair Follicle, Head, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Head, Inflammation, Acute            |                                                                          |             
      Head, Inflammation, Chronic Active   |                                                                          |             
      Tail, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Compression                          |    X        X        X     X                                             |             
      Hemorrhage                           |                   4  2     2           3        2                        |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Congestion                           |                      3                 4        3              2         |             
      Hemorrhage                           |    2                 1           3  1  2           1                     |             
      Infiltration Cellular, Lymphocyte    |    2     2  2  2  2  2  2  2     2  2  2  2     2  2  2     2  2  2  2   |             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       1                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2           1  2                 2        2        1            |             
      Arteriole, Mineralization            |             2        2  2  2     2  1  2  2     1  2  2     2  2  1  2   |             
      Bronchiole, Mineralization           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                             1            |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                      1                                1                  |             
      Pleura, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Lumen, Foreign Body                  |                            2        2              2                     |             
      Lumen, Hemorrhage                    |             1  2  2        2        2     2     1  2  3           2  1   |             
      Mucosa, Inflammation, Acute          |    2        1  1  2  2  1  3        2                 2     2  2  1      |             
      Mucosa, Inflammation, Chronic Active |                                                 2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                       2                  |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   |          1  2     2  2     2     2  2  2        2  2  2     2        2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Degeneration |                                     1              2  1                  |             
      Respiratory Epithelium, Erosion      |    2                                                                     |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                            2                                             |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Mineralization               |                                                                      3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Nephropathy, Chronic                 |    4     3  2  2  2  4  4  3     2  3  2  3     2  3  4     2  4  3  4   |             
      Renal Tubule, Cyst                   |                                                                      X   |             
      Renal Tubule, Hyperplasia            |                                                       1                  |             
      Renal Tubule, Pigmentation           |    2     2  2  1  2  1  2  2     3  2  2  2     1  2  2     2  1  2  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Calculus Gross Observation           |                                           X                              |             
      Hemorrhage                           |    2                                                                     |             
      Inflammation, Acute                  |    3                                                                     |             
      Inflammation, Chronic                |                                                             3            |             
      Inflammation, Chronic Active         |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +                                             |  50        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Angiectasis                          |                   1                                                      |      7  1.9|
      Congestion                           |                                                                          |      3  2.7|
      Developmental Malformation           |                                                                          |      1     |
      Fatty Change                         |    2                                                                     |      3  2.3|
      Focal Cellular Change                | X  X           X     X  X  X                                             |     28     |
      Granuloma                            |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.5|
      Bile Duct, Hyperplasia               | 2  2  2        4  3  1  1  2                                             |     48  2.1|
      Portal, Inflammation, Chronic        | 2  2  2        2  1  2  1  2                                             |     48  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
      Fat, Necrosis                        |                      3                                                   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  +  +                                             |  50        |
      Acinus, Atrophy                      | 2              2  3  2                                                   |     30  2.4|
      Acinus, Hyperplasia                  |                   2                                                      |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      1     |
      Erosion                              |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Inflammation, Acute                  |                                                                          |      4  2.5|
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
      Ulcer                                |                                                                          |      4  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mucosa, Dilatation                   |       2        2        1  1                                             |     17  1.7|
      Mucosa, Ectasia                      |                                                                          |      2  2.0|
      Mucosa, Erosion                      |       3           3                                                      |      4  2.3|
      Mucosa, Ulcer                        |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              | 3  2           3  3  3  2  3                                             |     49  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +                                             |  50        |
      Degeneration, Fatty                  | 2  3  2        2     2                                                   |     35  2.0|
      Hyperplasia                          |                   1  2     1                                             |     15  1.7|
      Hypertrophy                          |                            1                                             |      4  1.5|
      Pigmentation                         | 1  2  1           1  2  2  1                                             |     43  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +                                             |  49        |
      Hyperplasia                          |    1           2                                                         |     10  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M        +  +  +  +  +                                             |  42        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +  +  +                                             |  49        |
      Pars Distalis, Atrophy               |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                   X                                                      |      3     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           | 1              2           2                                             |     18  2.0|
      Pars Intermedia, Cyst                |                                                                          |      2     |
      Pars Nervosa, Pigmentation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |    1                                                                     |     12  1.7|
      Follicle, Ectasia                    |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +        +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      3  3.3|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                | 2              2     2  2                                                |     29  1.9|
      Inflammation, Chronic Active         |    3  2           2        2                                             |     10  2.3|
      Duct, Ectasia                        |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +        +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          | 2              2  2                                                      |     10  2.1|
      Inflammation, Acute                  |    2  3                                                                  |      7  2.6|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         | 2                       3                                                |     14  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +        +  +  +  +  +                                             |  50        |
      Atrophy                              | 1                                                                        |     11  2.2|
      Interstitial Cell, Hyperplasia       | 2  2  2        2  2        2                                             |     35  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +  +  +                                             |  50        |
      Myelofibrosis                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +  +                                             |  50        |
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      1  1.0|
      Mesenteric, Hyperplasia, Lymphoid    | 2                          2                                             |     17  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M        +  +  +  +  +                                             |  36        |
      Congestion                           |                            3                                             |     10  2.3|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                | 2  2           2  2  2  2  1                                             |     32  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +  +                                             |  50        |
      Fibrosis                             |                3  3                                                      |      5  3.0|
      Hematopoietic Cell Proliferation     | 1  2                 2  2  2                                             |     42  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation                         | 2  2                    1  2                                             |     39  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +        +  +  +  +  +                                             |  44        |
      Congestion                           |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +        +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
      Acinus, Ectasia                      |    3           3  2  3  2                                                |     34  2.4|
      Duct, Ectasia                        |    3                                                                     |     10  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +  +                                             |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Epidermis, Cyst                      |                                                                          |      1  3.0|
      Hair Follicle, Head, Hemorrhage      |                                                                          |      1  2.0|
      Hair Follicle, Head, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Head, Inflammation, Acute            |                            2                                             |      1  2.0|
      Head, Inflammation, Chronic Active   |                   2                                                      |      1  2.0|
      Tail, Inflammation, Chronic Active   |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +  +  +                                             |  50        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1  3.0|
      Femur, Fibrous Osteodystrophy        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Compression                          |                                                                          |      5     |
      Hemorrhage                           |       3        1                                                         |     11  2.5|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      6  2.8|
      Hemorrhage                           |                                                                          |      8  1.8|
      Infiltration Cellular, Lymphocyte    | 2  2  2        2  2  2  2  2                                             |     50  2.0|
      Pigmentation, Cholesterol            |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1     2           1  2     2                                             |     26  1.7|
      Arteriole, Mineralization            | 2     2        1  2  2  2  1                                             |     41  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchiole, Mineralization           |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  |                      2                                                   |      5  1.6|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      5  1.0|
      Pleura, Inflammation, Chronic Active |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +  +  +                                             |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Lumen, Foreign Body                  | 2                                                                        |      4  2.0|
      Lumen, Hemorrhage                    |                   2  3                                                   |     31  2.3|
      Mucosa, Inflammation, Acute          | 2              2  2  2  1  3                                             |     30  1.8|
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      4  2.0|
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   | 2  2  2        2  1  1  2  1                                             |     39  1.8|
      Respiratory Epithelium, Degeneration | 2              2                                                         |     15  1.7|
      Respiratory Epithelium, Erosion      |                   2        2                                             |      4  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
      Sclera, Mineralization               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 3  4  1        4  2  3  3  4                                             |     49  2.9|
      Renal Tubule, Cyst                   |                                                                          |      1     |
      Renal Tubule, Hyperplasia            |                2     4                                                   |      4  2.0|
      Renal Tubule, Pigmentation           | 2  2  2        2  2  1  2  1                                             |     50  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  +  +                                             |  50        |
      Calculus Gross Observation           |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hemorrhage                           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                            X     X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Parasite Metazoan                    |                                                 X                       X|             
      Ulcer                                |             4                                      3                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2     2               |             
      Congestion                           |                                                                   3      |             
      Developmental Malformation           |          X  X              X                                             |             
      Fatty Change                         |                         4                                                |             
      Focal Cellular Change                |       X  X  X  X        X  X           X           X     X     X        X|             
      Granuloma                            |                      2                                                   |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Hemorrhage                           |                                              2                           |             
      Necrosis                             |       3                                                                  |             
      Bile Duct, Dilatation                |                                                                          |             
      Bile Duct, Hyperplasia               | 2     3  2  4  2     2  2  2  2     2  2  2  3  2  2  2  2  2  3  2  2  2|             
      Bile Duct, Inflammation, Chronic     |                                                                          |             
      Portal, Inflammation, Chronic        |       2  2  3  2     2  1  2  2     1  2     3  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Acinus, Atrophy                      | 2           2  2     2     2  3        2  2  4  4  2  3  3     2  1      |             
      Acinus, Hyperplasia                  |             2                                         2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                         2                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Chronic Active         |                         4                                                |             
      Ulcer                                | 4                       4                    4                       3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Congestion                   |                                              2                           |             
      Mucosa, Dilatation                   |          2           2  2     2     2  2  2     1  1           2         |             
      Mucosa, Erosion                      | 2        2  2                 3     2                                2   |             
      Mucosa, Granuloma                    |                                                                          |             
      Mucosa, Hemorrhage                   |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Ulcer                        | 4                       4                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2  3  2     2  2  3  2     2  3  2  2     3  2  2  2  3  3  3  3|             
      Hemorrhage                           |                                                                          |             
      Atrium, Thrombosis                   |                                        X              X              X   |             
      Pericardium, Inflammation, Chronic   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 4     2  2  2  2     2  2  2  1        2  2  2  1  2  2  2  1     1  2  1|             
      Hyperplasia                          |                                        2                                2|             
      Hypertrophy                          |                                                                          |             
      Pigmentation                         | 2     2  2  1  2     2  2  2  2        2  2  2  2  2  2     2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                       2              2     2  2  2           2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                             2  3         |             
      Pars Distalis, Cyst                  |    X                                         X  X        X               |             
      Pars Distalis, Hyperplasia           |       3  3  3                          2           3  2  2  2  2         |             
      Pars Intermedia, Angiectasis         |                                                                3         |             
      Pars Intermedia, Cyst                |                                              X                           |             
      Pars Intermedia, Hyperplasia         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      2     2  1        1     1  2  1     2     2         |             
      Follicle, Ectasia                    |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Inflammation, Chronic                | 2     2  3           1  2  2           2     2  3  2  3  2               |             
      Inflammation, Chronic Active         |             2  4              3           2                 2  3     2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                               2               |             
      Inflammation, Acute                  |                                              2                       2   |             
      Inflammation, Chronic                |             2                                                            |             
      Inflammation, Chronic Active         |                3                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +                                                        +            |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1           2        2  4  4                    2     4                  |             
      Congestion                           |                                              2                           |             
      Mineralization                       |                                                                   1      |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Interstitial Cell, Hyperplasia       | 2     2  2  2  2     2  1  2  2        2  2  2  2  2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      3   |             
      Hyperplasia, Lymphoid                |       2  2                                                               |             
      Mediastinal, Congestion              |                                              4        4                  |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Hyperplasia, Lymphoid    |          2     2     2     2           2           2              2     2|             
      Mesenteric, Inflammation, Acute      |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +     M  +  M  +  +  +  M  +  M  +  +  +  +|             
      Congestion                           |                                        2        2  2                    2|             
      Cyst                                 |                                                          X               |             
      Hyperplasia, Lymphoid                | 3        2  3  2     2  3  3           3     2     2     3     2        2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          2               |             
      Hematopoietic Cell Proliferation     | 2     3  2  2  2     2  2  2  2     2  2     2     3  2  2  3  1  1  2  2|             
      Infarct                              |             4                                                            |             
      Pigmentation                         | 2  3     2  2  2     1  2  2           2        1        1  3  2  2  1  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |             4                                3              2            |             
      Cyst                                 |                               X                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Acinus, Ectasia                      | 3              4        4  2  2           2  3                 3  2  2  2|             
      Duct, Ectasia                        | 3           3              4  2           2  3  1        2     3     3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                         3|             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Hair Follicle, Inflammation, Chronic |                                                                          |             
      Head, Inflammation, Acute            |                      4                                                   |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Abscess                     |                                                                          |             
      Cranium, Fibrous Osteodystrophy      |          X                                                               |             
      Femur, Fibrous Osteodystrophy        |          X  X                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X              X     X  X  X                                             |             
      Hemorrhage                           |             2                       2        4              1            |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                        2            |             
      Hemorrhage                           |             2                                                            |             
      Infiltration Cellular, Lymphocyte    | 2  1  2  2  2  2     2  2  2        2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Pigmentation, Cholesterol            |                2                                   1                     |             
      Alveolar Epithelium, Hyperplasia     |                                                          3               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                2     2     2           2        2  1     2     1         |             
      Arteriole, Mineralization            | 2  2  2  2  2  2     2  2           2  2  2  2  2     2  2  2  2     2  2|             
      Interstitium, Inflammation, Chronic  |                            1           2           1                    1|             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                           4  3                           |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lumen, Foreign Body                  |                                     2        2              2  2         |             
      Lumen, Hemorrhage                    |             1  2     2     2        2     2  2              2     2      |             
      Mucosa, Hemorrhage                   |          1                                                               |             
      Mucosa, Inflammation, Acute          | 2  2     2     2     2     3  1     2  2  1  3        2  2  2  2  2      |             
      Nasolacrimal Duct, Degeneration      |                                                                      2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 1                                                                        |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  3     3  2  3  2     2  2  2  2  3  3     2  1  3  2  3  3|             
      Olfactory Epithelium, Erosion        |          2                                                               |             
      Olfactory Epithelium, Metaplasia     |                                              3                           |             
      Respiratory Epithelium, Degeneration | 3     2  2     3     3  2  2  1     1  3        1  2     1     1  1  3  1|             
      Respiratory Epithelium, Erosion      |                            2        2        2        2        2         |             
      Respiratory Epithelium, Hemorrhage   |                                                                2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                               +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Nephropathy, Chronic                 | 2     2  4  4  4     3  4  3  3     2  4  2  3  2  3  2  3  3  3  3  4  3|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Cyst                   |                                                                          |             
      Renal Tubule, Hyperplasia            |          3     2        4                                                |             
      Renal Tubule, Pigmentation           | 2     2  2  2  2     2  2  2  2     2  2  4  2  2  2  3  2  2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic                | 1                                                                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Erosion                              |                               1                                          |             
      Hemorrhage                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Erosion                              |                                                    3                     |             
      Parasite Metazoan                    |                   X     X                                                |             
      Ulcer                                | 3                                                     3                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Angiectasis                          | 2        2     2  2                 2                 2     2  2         |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                         X                                                |             
      Fatty Change                         |                                                       1                  |             
      Focal Cellular Change                | X     X  X     X  X           X     X  X  X  X              X            |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                        2                                 |             
      Necrosis                             |                                        3                                 |             
      Bile Duct, Dilatation                |                                                                          |             
      Bile Duct, Hyperplasia               | 2  3  2  2  2  2  2  2  4  2  1     2  3  2  2     2  2     2  2     2  2|             
      Bile Duct, Inflammation, Chronic     |                                                                          |             
      Portal, Inflammation, Chronic        | 2  2  2  2  2  2     1  3  2  1     2  2  2  3     2  2     2  2     2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Inflammation, Acute                  |                                                                      4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Inflammation, Acute                  |                                                                      3   |             
      Acinus, Atrophy                      | 2  2  2  3     3  1  4  2     1     1  2  2  3     2        1  2         |             
      Acinus, Hyperplasia                  |       2                                   2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Infiltration Cellular, Lymphocyte    |                                                    1                     |             
      Inflammation, Chronic                |       3                                                                  |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                      2                             1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                           2                              |             
      Ulcer                                |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Mucosa, Congestion                   |                                                                          |             
      Mucosa, Dilatation                   |    2  2  1  1  1        1                    2              2            |             
      Mucosa, Erosion                      |                            1                       2                 2  2|             
      Mucosa, Granuloma                    |                                              2                           |             
      Mucosa, Hemorrhage                   |                                                             3            |             
      Mucosa, Inflammation, Acute          |                                                                         3|             
      Mucosa, Ulcer                        |    4                 3                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  3     2  2  2  2  3  3     2  2  2  2     2  1     2  2     1  1|             
      Hemorrhage                           |                                                                          |             
      Atrium, Thrombosis                   |                      X                                                   |             
      Pericardium, Inflammation, Chronic   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Degeneration, Fatty                  |       1  2     1  2  2  2  1  3        2  1  1     1  1     2           1|             
      Hyperplasia                          |                2        2  2              2           2     2  2         |             
      Hypertrophy                          |                2  2     2  2           1                                 |             
      Pigmentation                         | 2  2  2  2  2  2  2  2  2  2  2     1  2  2  1     1  2     2  2        1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Hyperplasia                          |             3        2                       2              1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Hyperplasia                          |       2                       1           2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +     +  M  +  +     +  +     +  M     +  +|             
      Hyperplasia                          |                                                                         3|             
      Hypertrophy                          |                         2                                   2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Pars Distalis, Angiectasis           |       2                                                                  |             
      Pars Distalis, Cyst                  |                      X  X                                                |             
      Pars Distalis, Hyperplasia           | 2     2  3  2  2        2  2              3  3                 1         |             
      Pars Intermedia, Angiectasis         |                                                                         3|             
      Pars Intermedia, Cyst                |          X                                                               |             
      Pars Intermedia, Hyperplasia         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      C-Cell, Hyperplasia                  |       2  2  2  2  1  2     1           1  1                              |             
      Follicle, Ectasia                    |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |    2     4        2  3  2  2  2     3  2  2  2     2        2           2|             
      Inflammation, Chronic Active         | 3     4     3  3                                      2        2         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Hyperplasia                          |       2                                                                  |             
      Inflammation, Acute                  |                1              2     2              2                     |             
      Inflammation, Chronic                |          2                                                     1         |             
      Inflammation, Chronic Active         |                      2                    2           3     4            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +                                                      |             
      Dilatation                           |                   3                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Atrophy                              | 3                    4                             2        2            |             
      Congestion                           |                                                                          |             
      Mineralization                       |                      3                                                   |             
      Arteriole, Inflammation, Chronic     |                                                             4            |             
      Interstitial Cell, Hyperplasia       | 2  2  2  2  2  2  2  2  2  2  2     2  2  2  2     2  2        2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Myelofibrosis                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinal, Congestion              |                                                    3        3        4   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3            |             
      Mesenteric, Congestion               |                                                                      2   |             
      Mesenteric, Hyperplasia, Lymphoid    | 2           2  2              2     2     2        2           2     2   |             
      Mesenteric, Inflammation, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     M  +|             
      Congestion                           | 3     3                             2              2        3            |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |       2  2  2  2  3           3     2  3  2        2  2     2  2        2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Fibrosis                             |                                        3                             4   |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  3  2  1        2  2     2     2  2        2     2  2     3  2|             
      Infarct                              |                                                                          |             
      Pigmentation                         | 2     2  2  2  2  1  2     2  2     2  1  2        3  2     2  2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     M  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Congestion                           |       2                                            2                     |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |       2                       2                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Acinus, Ectasia                      |    2              2  3  2  2  2     2  4  2        1  1     4           2|             
      Duct, Ectasia                        |    2  2     2              2  2           2                 4  1         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Abscess                              |                                                                          |             
      Cyst Epithelial Inclusion            |                         X                                                |             
      Hair Follicle, Inflammation, Chronic |    2                                                                     |             
      Head, Inflammation, Acute            |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Cranium, Abscess                     |                                                                          |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Compression                          |                                     X  X                                 |             
      Hemorrhage                           |                                        2                    2           4|             
      Necrosis                             |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Congestion                           |                                                    4                     |             
      Hemorrhage                           |                                                                         2|             
      Infiltration Cellular, Lymphocyte    | 2     2  2  2  2  2  2  2  2  2     2  2  2  2     2  2     2  2     2  2|             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2     1           2  2  2           2  2                                2|             
      Arteriole, Mineralization            |    1        2  2  2  2     2  2     2  2  1  2     2  2     2  2        2|             
      Interstitium, Inflammation, Chronic  |       1              2                                                   |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lumen, Foreign Body                  |    2                                                                     |             
      Lumen, Hemorrhage                    |    2  2  2  2  1  2                 2     2  2     2        1  2        1|             
      Mucosa, Hemorrhage                   |                                                                          |             
      Mucosa, Inflammation, Acute          | 2  4  2     2           2     2        2  2                 2  2        2|             
      Nasolacrimal Duct, Degeneration      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   | 3  2  3  2  3  2  2  2  3  3  3     3  3  2  2     3  3     2  3        3|             
      Olfactory Epithelium, Erosion        |    3                                                        2            |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Degeneration | 1     1     1  2  1  1     1  1     1  2     1     2  2        1         |             
      Respiratory Epithelium, Erosion      |    2                                                                     |             
      Respiratory Epithelium, Hemorrhage   |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Inflammation, Acute                  |    2                                                                     |             
      Inflammation, Chronic Active         |                               2              2                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Congestion                           |                                                                          |             
      Nephropathy, Chronic                 | 3  3  4  4  3  3  3  4  3  2  4     3  4  3  3     2  2     4  4        2|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Cyst                   | X                                                                        |             
      Renal Tubule, Hyperplasia            |                                                             4            |             
      Renal Tubule, Pigmentation           | 2  3  2  2  2  2  2  2  2  2  2     2  2  2  2     1  2     2  2        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                             4            |             
      Transitional Epithelium, Hyperplasia |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +        +     +  +  +                                             |  50        |
      Erosion                              |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +        +     +  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +        +     +  +  +                                             |  50        |
      Erosion                              |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      4     |
      Ulcer                                |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +        +     +  +  +                                             |  50        |
      Angiectasis                          | 2                                                                        |     11  2.0|
      Congestion                           | 3                                                                        |      2  3.0|
      Developmental Malformation           |                                                                          |      4     |
      Fatty Change                         |                                                                          |      2  2.5|
      Focal Cellular Change                |                            X                                             |     23     |
      Granuloma                            |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                      1                                                   |      2  1.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      2  3.0|
      Bile Duct, Dilatation                |                4                                                         |      1  4.0|
      Bile Duct, Hyperplasia               | 1     3        3     2  3  2                                             |     49  2.2|
      Bile Duct, Inflammation, Chronic     |                4                                                         |      1  4.0|
      Portal, Inflammation, Chronic        |       3        2     1  2  2                                             |     45  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   2        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +        +     +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                2        2  1                                             |     34  2.2|
      Acinus, Hyperplasia                  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +        +     +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +        +     +  +  +                                             |  50        |
      Erosion                              | 3                                                                        |      1  3.0|
      Hyperplasia, Squamous                | 2                                                                        |      1  2.0|
      Inflammation, Acute                  |                                                                          |      3  2.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Ulcer                                | 4     4                                                                  |      7  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +        +     +  +  +                                             |  50        |
      Mucosa, Congestion                   |                                                                          |      1  2.0|
      Mucosa, Dilatation                   |                2     2     2                                             |     21  1.7|
      Mucosa, Erosion                      |                         3                                                |     11  2.1|
      Mucosa, Granuloma                    |                                                                          |      1  2.0|
      Mucosa, Hemorrhage                   |                                                                          |      1  3.0|
      Mucosa, Inflammation, Acute          |                                                                          |      1  3.0|
      Mucosa, Ulcer                        |                         4                                                |      5  3.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +        +     +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              | 3              2     3  2  2                                             |     47  2.2|
      Hemorrhage                           |                         2                                                |      1  2.0|
      Atrium, Thrombosis                   | X                       X                                                |      6     |
      Pericardium, Inflammation, Chronic   | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +        +     +  +  +                                             |  50        |
      Degeneration, Fatty                  | 2     2        1     2  2  2                                             |     41  1.7|
      Hyperplasia                          |                      2                                                   |     10  2.0|
      Hypertrophy                          |                                                                          |      5  1.8|
      Pigmentation                         | 2     2        2     2  1  2                                             |     46  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +        +     +  +  +                                             |  50        |
      Hyperplasia                          | 2     2        3     2                                                   |     15  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +        +     +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M        +     +  +  +                                             |  45        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Hypertrophy                          |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +        +     +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.3|
      Pars Distalis, Cyst                  |                                                                          |      6     |
      Pars Distalis, Hyperplasia           | 3              2        3                                                |     22  2.4|
      Pars Intermedia, Angiectasis         |                                                                          |      2  3.0|
      Pars Intermedia, Cyst                |                                                                          |      2     |
      Pars Intermedia, Hyperplasia         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +        +     +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  |                      1     1                                             |     20  1.5|
      Follicle, Ectasia                    |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +        +     +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |       2        2                                                         |     28  2.2|
      Inflammation, Chronic Active         | 3                    2  2                                                |     17  2.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +        +     +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      3  1.7|
      Inflammation, Acute                  |       3                                                                  |      7  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Inflammation, Chronic Active         |                            3                                             |      6  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +     +                                             |   5        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +        +     +  +  +                                             |  50        |
      Atrophy                              |       1                                                                  |     12  2.6|
      Congestion                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.0|
      Arteriole, Inflammation, Chronic     |                            2                                             |      2  3.0|
      Interstitial Cell, Hyperplasia       | 2     2        2     2  2  2                                             |     46  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +        +     +  +  +                                             |  50        |
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +     +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Mediastinal, Congestion              |                                                                          |      5  3.6|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mesenteric, Congestion               |                                                                          |      1  2.0|
      Mesenteric, Hyperplasia, Lymphoid    | 2                    2     2                                             |     20  2.0|
      Mesenteric, Inflammation, Acute      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +        +     +  +  +                                             |  45        |
      Congestion                           | 4                                                                        |     10  2.5|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |       3        2     3     2                                             |     31  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +        +     +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      3  3.0|
      Hematopoietic Cell Proliferation     | 2              2     2  1  2                                             |     42  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Pigmentation                         | 2     1        2     1     1                                             |     37  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +        M     +  +  M                                             |  46        |
      Congestion                           |                                                                          |      5  2.6|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                | 3                                                                        |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     M        +     +  +  +                                             |  48        |
      Acinus, Ectasia                      |                         3                                                |     25  2.4|
      Duct, Ectasia                        |                2                                                         |     19  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +     +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  3.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hair Follicle, Inflammation, Chronic |                                                                          |      1  2.0|
      Head, Inflammation, Acute            |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           | 4                                                                        |      1  4.0|
      Subcutaneous Tissue, Hemorrhage      | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +        +     +  +  +                                             |  50        |
      Cranium, Abscess                     |                            4                                             |      1  4.0|
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1     |
      Femur, Fibrous Osteodystrophy        |                      X                                                   |      4     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +        +     +  +  +                                             |  50        |
      Compression                          |                                                                          |      7     |
      Hemorrhage                           |                         4                                                |      8  2.6|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +        +     +  +  +                                             |  50        |
      Congestion                           |                                                                          |      3  3.0|
      Hemorrhage                           |                         2  1                                             |      4  1.8|
      Infiltration Cellular, Lymphocyte    | 2              2     2  2  2                                             |     47  2.0|
      Pigmentation, Cholesterol            |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2              2                                                         |     18  1.8|
      Arteriole, Mineralization            | 2     2        2     2     2                                             |     40  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      6  1.3|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic                          |       3                                                                  |      3  3.3|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +        +     +  +  +                                             |  50        |
      Lumen, Foreign Body                  |                                                                          |      5  2.0|
      Lumen, Hemorrhage                    |       2        1     3                                                   |     25  1.8|
      Mucosa, Hemorrhage                   |                                                                          |      1  1.0|
      Mucosa, Inflammation, Acute          |       2        3           2                                             |     30  2.1|
      Nasolacrimal Duct, Degeneration      |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration   | 3     2        3     3  2  2                                             |     48  2.5|
      Olfactory Epithelium, Erosion        |                                                                          |      3  2.3|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  3.0|
      Respiratory Epithelium, Degeneration | 1     2        2     1  1  1                                             |     37  1.6|
      Respiratory Epithelium, Erosion      |                                                                          |      6  2.0|
      Respiratory Epithelium, Hemorrhage   |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +        +     +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                2                                                         |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +     +  +  +                                             |  50        |
      Congestion                           | 3                                                                        |      1  3.0|
      Nephropathy, Chronic                 | 3     3        4     4  2  4                                             |     48  3.1|
      Pelvis, Inflammation, Acute          |       3                                                                  |      1  3.0|
      Renal Tubule, Cyst                   |                X                                                         |      2     |
      Renal Tubule, Hyperplasia            |                                                                          |      4  3.3|
      Renal Tubule, Pigmentation           | 2     2        2     2  1  2                                             |     48  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +        +     +  +  +                                             |  50        |
      Calculus Micro Observation Only      |       X                                                                  |      1     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Granuloma                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Acute                  |       3                                                                  |             
      Parasite Metazoan                    |    X                       X  X              X                           |             
      Ulcer                                |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |          2                    2                                          |             
      Congestion                           |                                                                          |             
      Developmental Malformation           | X                                                                        |             
      Fatty Change                         |    1     2     1                                               3         |             
      Focal Cellular Change                | X  X     X                 X  X  X  X  X     X        X                  |             
      Granuloma                            |                                        2                                 |             
      Necrosis                             |                                                                         2|             
      Bile Duct, Hyperplasia               | 3  2  2  2     1  2  2  3  2  1  2  2  2  1  2  3  3  2  2  2  1  2     3|             
      Portal, Inflammation, Chronic        | 2  2  2  2        2  2  2  2  1  2  1  2  1  2  3  2  1  2  2     2     2|             
      Serosa, Fibrosis                     | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Arteriole, Inflammation, Chronic     |                                  2                                       |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acinus, Atrophy                      | 2     1        2     3  2  2     1     2     3        1           2      |             
      Acinus, Hyperplasia                  |                                                                          |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Arteriole, Mineralization            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acinus, Atrophy                      |                               1                                          |             
      Arteriole, Mineralization            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Ulcer                                |                4                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                           2                              |             
      Inflammation, Chronic Active         |                4                                               2         |             
      Mineralization                       |       3                                                                  |             
      Ulcer                                |                         3                                   4           3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                4                                                         |             
      Mineralization                       |       3                                                                  |             
      Mucosa, Dilatation                   |                2              2           2     2           2           2|             
      Mucosa, Erosion                      |       2        2        2                       2           1           1|             
      Mucosa, Ulcer                        |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Aorta, Mineralization                |       3                                                                  |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cardiomyopathy, Chronic              | 2  1  4  2     2     3  3  3  3  2  3  2  2  1  1  2  2  3  2  2  3     3|             
      Mineralization                       |       3                                                                  |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Degeneration, Fatty                  | 2        1     2  1  2  2  1        1  1  3  2  2     2  2  3  3  2     2|             
      Hyperplasia                          |          1                 2  1  3  2                                    |             
      Hypertrophy                          |                                                                         2|             
      Pigmentation                         | 1  1  2  2     2     2  2  1  1  2  1  2  1  2  2  2  2  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                          1     2        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |    2                       2                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                    X                     |             
      Pars Distalis, Hemorrhage            |                                                       2                  |             
      Pars Distalis, Hyperplasia           |    3                    2  2           3           2  2                  |             
      Pars Intermedia, Angiectasis         |                                                          3               |             
      Pars Intermedia, Cyst                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Ultimobranchial Cyst                 |    X                       X                                             |             
      C-Cell, Hyperplasia                  | 1        1              1  1     2                                       |             
      Follicle, Ectasia                    |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2  2     2              2     2        2     2     2     2  2            |             
      Inflammation, Chronic Active         |       3        2     2     2     3  3     2     3     2        3  3     3|             
      Mineralization                       |                                                                   2      |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                  2  1                             2      |             
      Inflammation, Acute                  |                2                                                        4|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         | 2                                         4                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                                           3              3  3           4|             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Interstitial Cell, Hyperplasia       |          1     2  2  2  2  2  2  2  2  2  1  2  1  2     2  2  2  2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Myelofibrosis                        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                   2      |             
      Mesenteric, Congestion               |                                                 2                        |             
      Mesenteric, Hyperplasia, Lymphoid    | 2  2     2     2                       2     2        2           2      |             
      Popliteal, Hyperplasia, Lymphoid     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  M  M  M  +  +  +  +  +  M  +  M  +  +  +  +  M  +     +|             
      Congestion                           |                                              2                           |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2  2  2     2           2  2  2  2  2     2     2  2  2        2     2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Fibrosis                             |                2        3                             3                  |             
      Hematopoietic Cell Proliferation     | 2  2  1  2     3     2     2  2  2  2  1  1  2  2  2  3  2  2  2  2     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Pigmentation                         | 2  1  3  2     2  2  2     2  1  2     1  3  1  2     2  1     2  2     1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acinus, Ectasia                      |       2        2     3  2           1     3  3     2     4  2  3        3|             
      Duct, Ectasia                        |                      3                          2  2     3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Abscess                              |                                                                          |             
      Foot, Ulcer                          |                                                                          |             
      Head, Abscess                        |                                                 2                        |             
      Head, Inflammation, Acute            |                                                                          |             
      Tail, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Acute              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cranium, Fibrous Osteodystrophy      |       4                                                                  |             
      Cranium, Inflammation, Chronic       |                                                                          |             
      Femur, Fibrous Osteodystrophy        |       3                                                                  |             
      Humerus, Fracture                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Compression                          |                X                                X                        |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Congestion                           |       3                          2                                       |             
      Hemorrhage                           | 1  1                                               1                     |             
      Infiltration Cellular, Lymphocyte    | 2  2  2  2     2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2     2|             
      Inflammation, Chronic                |                                              1                           |             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation, Cholesterol            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               2     2  2                                 |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1  2        2        2  2  2  1  2  2  2              2               |             
      Alveolus, Mineralization             |    2                                                                     |             
      Arteriole, Mineralization            | 2     2  2     2  2  2              2  2     2     2  2  2  2  2  1     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bronchiole, Inflammation, Acute      |       2                                                                  |             
      Interstitium, Inflammation, Chronic  |    1                       1           1                                 |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Lumen, Degeneration                  |                                                                   2      |             
      Lumen, Foreign Body                  |    2  2                                                                  |             
      Lumen, Hemorrhage                    | 2  3     2     2           1     2  1  1  2  3        2  2  3     2     3|             
      Mucosa, Inflammation, Acute          | 2  3  3  3              2  1  2  2  2  2  2  1  2  1  2  2  2  2        2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                              3                          2|             
      Olfactory Epithelium, Degeneration   | 4  3     3     2        1  2  2  3  3  3  2  3  2  2  3  3  3  2        3|             
      Olfactory Epithelium, Erosion        |                               2  2  2  2                 1               |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                  2                                       |             
      Respiratory Epithelium, Degeneration | 3  2     1     1           2  1  3  3  2  2  2     2  3  3  1            |             
      Respiratory Epithelium, Erosion      |    2                                                                     |             
      Respiratory Epithelium, Ulcer        |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Acute                  |                                              1                    2      |             
      Inflammation, Chronic Active         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                        3                                 |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Mineralization               |                                        2                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infarct                              |                                                                          |             
      Mineralization                       |       3                                                                  |             
      Nephropathy, Chronic                 | 2  3  4  3     4     3  3  4  4  4  4  4  4  2  3  2  4  4  2  4  4     4|             
      Pelvis, Inflammation, Acute          |                                           4                              |             
      Renal Tubule, Cyst                   |                               X                                X         |             
      Renal Tubule, Pigmentation           | 1  1  2  1     2     2  2  1  1  2  2  1  2  2  2  3  2  2  1  2  2     3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Granuloma                            |                                                                      3   |             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                                                                   X  X   |             
      Ulcer                                |          3                                         4                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Erosion                              |                            2                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Erosion                              |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |             2                                                            |             
      Developmental Malformation           |                                                                         X|             
      Fatty Change                         |             2  2                                         2               |             
      Focal Cellular Change                |          X           X  X     X  X              X        X        X     X|             
      Granuloma                            |                                                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |          2  2  1  3  2  1  3  2  2        1  2  2  4  3  2     2  2  2  2|             
      Portal, Inflammation, Chronic        |          2  2     2  2  1  2  2  2        1  2  2  3  2  2     2  2  2  2|             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +  +                     |             
      Arteriole, Inflammation, Chronic     |                                                 2                        |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                                                          |             
      Fat, Necrosis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Acinus, Atrophy                      |          3     2  2  2  2  2  3  2           2  3  3  2  2     1     2  1|             
      Acinus, Hyperplasia                  |                                  2                                       |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                      3                                                   |             
      Arteriole, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Arteriole, Mineralization            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                                                    3                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |          3     4           3                       3     4               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Mucosa, Dilatation                   |                      2     2  2              2     2     2           2   |             
      Mucosa, Erosion                      |                            3                             2               |             
      Mucosa, Ulcer                        |                3                                   4                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
          Active                           |                      4                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Cardiomyopathy, Chronic              |          3  2  2  2  3  2  2  2           2  3  3  2  2  2     2  3  3  3|             
      Mineralization                       |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                            X  X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Degeneration, Fatty                  |          2  1  2  2  1  1  2  1  1        2  1     2  1  3     2  1  1   |             
      Hyperplasia                          |          2     2  2                             1                 1      |             
      Hypertrophy                          |                                                       2                  |             
      Pigmentation                         |          2  2  2  1        2  2  1           2     2  2  2           1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +  M  +  +  +  +  +  +  M        +  +  +  M  +  +     M  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                   X           X                    X                 X   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                      1        2           2                       2      |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          2                 1     1              1  2     2     1         |             
      Follicle, Ectasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                    3                     |             
      Inflammation, Chronic                |                         3                 1        2  1        3  2      |             
      Inflammation, Chronic Active         |          2     2  2  2     3  2  3              3        2           3  3|             
      Mineralization                       |                                                                          |             
      Duct, Ectasia                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Prostate                                |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                       2                  |             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Chronic Active         |                         2  4  3              3                    4  3   |             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |                         3  2                       4                     |             
      Arteriole, Inflammation, Chronic     |                         2                                                |             
      Interstitial Cell, Hyperplasia       |          2  2     2  2  1  2     2           2  2  2  2        2     2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                                            +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Myelofibrosis                        |                                                 2  3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                    3                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mesenteric, Congestion               |                               2                    3     2               |             
      Mesenteric, Hyperplasia, Lymphoid    |             2  2     2                    2  1  1              2  2     2|             
      Popliteal, Hyperplasia, Lymphoid     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  M  M  M  +  +  +  +  +        +  M  +  +  M  +     +  +  +  +|             
      Congestion                           |                                  2                                      2|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |          3           2  2     2           2     2        2           1  2|             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Fibrosis                             |                               3                                          |             
      Hematopoietic Cell Proliferation     |          2  2  2     2  2     1           1  1     2     2        2  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2                 2      |             
      Pigmentation                         |          2  2  2     2  2  1  1  2        2  2  2        3     2  2  1  2|             
                                            __________________________________________________________________________|             
   Thymus                                  |          M  +  +  +  +  +  +  +  +        +  +  +  +  +  M     +  +  +  +|             
      Congestion                           |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Acinus, Ectasia                      |                3        4  4     2           2     3     3     2     1  1|             
      Duct, Ectasia                        |                                                          3     2         |             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Abscess                              |                                                                          |             
      Foot, Ulcer                          |                                                    4                     |             
      Head, Abscess                        |                                                                          |             
      Head, Inflammation, Acute            |                                                                          |             
      Tail, Subcutaneous Tissue,           |                                                                          |             
          Inflammation, Acute              |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                                          1               |             
      Cranium, Inflammation, Chronic       |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                                                          1               |             
      Humerus, Fracture                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Compression                          |                X                                         X               |             
      Hemorrhage                           |             2                                2                           |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |             1                 2                                          |             
      Hemorrhage                           |                1                                         2               |             
      Infiltration Cellular, Lymphocyte    |          2  2  2  2  2  2  2  2  2        2  2  2  2  2  2     2  2  2  2|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                            1                                             |             
      Pigmentation, Cholesterol            |          2                                         1                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2           2  2  2  1           2     2                 2  1  1|             
      Alveolus, Mineralization             |          2                                                               |             
      Arteriole, Mineralization            |             2     2  2     2  2  2        1  2  2  2     2        2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bronchiole, Inflammation, Acute      |                                                                3         |             
      Interstitium, Inflammation, Chronic  |                      1  1                 1     1                    1   |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Lumen, Degeneration                  |                                                                          |             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Hemorrhage                    |          2        2  2  2        2        2     2     2  2     3  3  2  2|             
      Mucosa, Inflammation, Acute          |          1        2  2  2     1  2           2  2  3  2  2        2  1  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Degeneration   |          3     1  2  3  3  2  3  3        1     3  2     2     2  3  3  3|             
      Olfactory Epithelium, Erosion        |                               2                          2               |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                         2                                                |             
      Respiratory Epithelium, Degeneration |          2           2  2     2  2              1                 2  1  1|             
      Respiratory Epithelium, Erosion      |          3                                               2               |             
      Respiratory Epithelium, Ulcer        |                                                          2               |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |             1                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                2         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         2|             
      Retina, Degeneration                 |                                                                         4|             
      Sclera, Mineralization               |                                                                         2|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Infarct                              |                                                                         3|             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 |          4  3  4  3  4  4  4  4  2        2  3  2  4  2  4     2  1  4  3|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Cyst                   |          X     X                                                         |             
      Renal Tubule, Pigmentation           |          2  2  2  1  1  2  3  2  1           1  1  3  2  2     2  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +                                                |  49        |
      Granuloma                            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +                                                |  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Parasite Metazoan                    |    X                                                                     |      7     |
      Ulcer                                |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +                                                |  49        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +                                                |  49        |
      Erosion                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Angiectasis                          |                      2                                                   |      3  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                                                                          |      2     |
      Fatty Change                         |                         3                                                |      8  2.0|
      Focal Cellular Change                |    X  X  X           X                                                   |     23     |
      Granuloma                            |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  2  2        3  2  2                                                |     49  2.1|
      Portal, Inflammation, Chronic        | 2  2  2  2     1  3     1                                                |     46  1.9|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
      Arteriole, Inflammation, Chronic     |                                                                          |      2  2.0|
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                      3                                                   |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Acinus, Atrophy                      |       2  3        3                                                      |     30  2.1|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Arteriole, Mineralization            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Arteriole, Mineralization            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  50        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  49        |
      Erosion                              |                         3                                                |      1  3.0|
      Hyperplasia, Squamous                |                         3                                                |      2  3.0|
      Inflammation, Acute                  |                         3                                                |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |          4                                                               |      9  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  49        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Mineralization                       |                      2                                                   |      2  2.5|
      Mucosa, Dilatation                   |    1     2        2  2  2                                                |     18  1.9|
      Mucosa, Erosion                      |                         3                                                |      9  2.0|
      Mucosa, Ulcer                        |                                                                          |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +     +  +  +  +                                                |  50        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
      Thoracic, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Cardiomyopathy, Chronic              | 1  2  2  2        3  3  2                                                |     47  2.3|
      Mineralization                       |                                                                          |      1  3.0|
      Artery, Mineralization               |    2                                                                     |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Degeneration, Fatty                  | 3  1  1  3     2  1  1  2                                                |     43  1.7|
      Hyperplasia                          |          2                                                               |     11  1.7|
      Hypertrophy                          |    2                                                                     |      3  2.0|
      Pigmentation                         | 1  2     2              2                                                |     39  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  50        |
      Hyperplasia                          |                   2                                                      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +     +  +  +  +                                                |  44        |
      Hyperplasia                          |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Pars Distalis, Angiectasis           |                      3                                                   |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      5     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                      2                                                   |     11  2.1|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      Infiltration Cellular, Lymphocyte    | 2                                                                        |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |          1           2                                                   |     14  1.4|
      Follicle, Ectasia                    | 2  2                                                                     |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                | 2  3  3        1  2  2                                                   |     22  2.0|
      Inflammation, Chronic Active         |          2              3                                                |     25  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Duct, Ectasia                        | 3                                                                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +                                                |  50        |
      Hyperplasia                          |                                                                          |      3  1.7|
      Inflammation, Acute                  | 4        2                                                               |      5  2.8|
      Inflammation, Chronic                |                   2                                                      |      2  2.0|
      Inflammation, Chronic Active         |       3                 2                                                |     10  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Atrophy                              |    3                    3                                                |      9  3.1|
      Arteriole, Inflammation, Chronic     |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       | 2  2  2           2     2                                                |     37  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                   +                                                      |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +                                                |  50        |
      Myelofibrosis                        |                   2  3                                                   |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mesenteric, Congestion               |                                                                          |      4  2.3|
      Mesenteric, Hyperplasia, Lymphoid    |    2     2     2     2  2                                                |     22  1.9|
      Popliteal, Hyperplasia, Lymphoid     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M     M  +  +  +                                                |  37        |
      Congestion                           |                                                                          |      3  2.0|
      Cyst                                 |                      X                                                   |      1     |
      Hyperplasia, Lymphoid                | 2  2  2              3  2                                                |     30  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Fibrosis                             |                                                                          |      4  2.8|
      Hematopoietic Cell Proliferation     | 2  2  2        2  1     1                                                |     40  1.8|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Pigmentation                         | 2  2  1  2     2     1  2                                                |     42  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  M  +  +                                                |  46        |
      Congestion                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +                                                |  49        |
      Acinus, Ectasia                      | 2  3  4  3           2  3                                                |     28  2.6|
      Duct, Ectasia                        |       3                 3                                                |      8  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Abscess                              |          4                                                               |      1  4.0|
      Foot, Ulcer                          |                                                                          |      1  4.0|
      Head, Abscess                        |                                                                          |      1  2.0|
      Head, Inflammation, Acute            |       2                                                                  |      1  2.0|
      Tail, Subcutaneous Tissue,           |                                                                          |            |
          Inflammation, Acute              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      2  2.5|
      Cranium, Inflammation, Chronic       |          4                                                               |      1  4.0|
      Femur, Fibrous Osteodystrophy        |                                                                          |      2  2.0|
      Humerus, Fracture                    |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Compression                          |          X              X                                                |      6     |
      Hemorrhage                           |                                                                          |      2  2.0|
      Necrosis                             |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Congestion                           |                                                                          |      4  2.0|
      Hemorrhage                           |                                                                          |      5  1.2|
      Infiltration Cellular, Lymphocyte    | 2  2  2  2     2  2  2  2                                                |     49  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Pigmentation, Cholesterol            |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1  1        2  2                                                      |     25  1.7|
      Alveolus, Mineralization             |                                                                          |      2  2.0|
      Arteriole, Mineralization            | 2  2  2  2     2  2  2  1                                                |     38  1.9|
      Bronchiole, Inflammation, Acute      |                                                                          |      2  2.5|
      Interstitium, Inflammation, Chronic  |    1  1                                                                  |     10  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                2                                                         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +                                                |  49        |
      Lumen, Degeneration                  |                                                                          |      1  2.0|
      Lumen, Foreign Body                  |                                                                          |      2  2.0|
      Lumen, Hemorrhage                    | 3  1  3  2     3     2  2                                                |     35  2.1|
      Mucosa, Inflammation, Acute          | 1  2  2  1        1  1  2                                                |     40  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  2.5|
      Olfactory Epithelium, Degeneration   | 3  3  3  3        3  3  3                                                |     42  2.6|
      Olfactory Epithelium, Erosion        |                      2                                                   |      8  1.9|
      Olfactory Epithelium, Metaplasia     |                      2                                                   |      1  2.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
      Respiratory Epithelium, Degeneration | 1  1  2  3        1  2  2                                                |     31  1.9|
      Respiratory Epithelium, Erosion      |                                                                          |      3  2.3|
      Respiratory Epithelium, Ulcer        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05701-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:31:19  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
      Inflammation, Acute                  |                                                                          |      3  1.7|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  2.5|
      Retina, Degeneration                 |                                                                          |      1  4.0|
      Sclera, Mineralization               |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Infarct                              |          3                                                               |      2  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 2  3  4  4        3  4  4                                                |     48  3.3|
      Pelvis, Inflammation, Acute          |                                                                          |      1  4.0|
      Renal Tubule, Cyst                   |                      X                                                   |      5     |
      Renal Tubule, Pigmentation           | 2  1  1  2        2  2  2                                                |     47  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.