TR 371 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05701 TOLUENE TIME: 13:26:28
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 07272B
CONT: 0570001 CAS: 108883
PATHOLOGIST: J. SAGARTZ
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05701 TOLUENE TIME: 13:26:28
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 07272B
CONT: 0570001 CAS: 108883
PATHOLOGIST: J. SAGARTZ
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 338 416 472 473 589 602 614 618 622 625 |
| 625 631 645 652 663 672 673 676 677 701 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 29 283 478 570 572 577 614 618 624 625 |
| 670 681 686 688 689 698 698 698 711 711 |
| 713 722 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 205 478 495 540 543 556 558 560 596 597 |
| 597 606 619 632 636 641 652 659 671 681 |
| 681 691 704 708 715 722 726 726 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.3 96.7 92.6 92.6 88.6 70.5 60.4 |
| | |
| | |
|600 PPM | 98.3 98.3 98.3 96.7 96.7 94.7 94.7 88.6 80.6 56.4 |
| | |
| | |
|1200 PPM | 100.0 100.0 98.3 98.3 98.3 96.3 90.3 78.3 64.2 44.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 600 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.4% 56.4% 44.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.169 P=1.000 P=0.206 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.2 607.0 614.1 |
|NATURAL DEATHS (C) | (21.7) (34.8) (20.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 640.7 639.2 630.3 |
|(STANDARD ERROR) | (14.8) (17.9) (15.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 430 491 568 583 626 638 639 642 644 655 |
| 675 675 697 708 710 719 722 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 414 457 537 540 553 554 653 653 658 676 |
| 679 681 681 711 717 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 165 421 561 563 564 584 606 606 630 640 |
| 648 648 652 654 667 673 693 706 708 723 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 92.3 80.3 66.2 |
| | |
| | |
|600 PPM | 100.0 100.0 100.0 100.0 98.3 96.7 92.6 88.6 82.6 70.5 |
| | |
| | |
|1200 PPM | 100.0 98.3 98.3 98.3 96.7 96.7 96.7 88.6 72.5 60.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 600 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.2% 70.5% 60.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.519 P=0.843N P=0.573 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 636.6 610.9 605.6 |
|NATURAL DEATHS (C) | (19.5) (24.4) (27.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 657.7 654.4 642.8 |
|(STANDARD ERROR) | (13.8) (14.4) (15.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
600 PPM = 2
1200 PPM = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 3 2 1 1 12 3
| 2 3 3 2
| 1 1
P 90 + 3 3 22 11
E | 2 1 11
R | 3 3 22
C | 11
E 80 + 2 2
N | 33 311 1 2 2
T | 3 3 11 22
| 1 1
S 70 + 33 11 22
U | 3 3 11
R | 3 33 2 2
V | 313 1
I 60 + 1 1
V | 33 2 2 2
A | 3 33
L | 33
50 + 33
|
| 3 3
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
600 PPM = 2
1200 PPM = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 231 2 1
|
| 3 2 1 2 31
95 + 22
| 1 1
| 22 1 1
| 223 3
P 90 + 1 1
E | 2 3 3 2
R |
C |
E 85 + 3 3
N |
T | 3 1 1 2
|
S 80 + 331 1
U | 22
R |
V | 33 1 1
I 75 + 2 2
V | 1 1
A | 3 3 22
L |
70 + 33 11 2
| 3 3 11
|
| 3 3 1 1
65 + 33
|
| 3 3
|
60 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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