National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5096

TR 371 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/18/94   
EXP: 05701                         TOLUENE                     TIME: 13:26:28   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 07272B   
CONT: 0570001                                                  CAS: 108883      
PATHOLOGIST: J. SAGARTZ                                                         
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/18/94  
EXP: 05701                         TOLUENE                     TIME: 13:26:28  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 07272B  
CONT: 0570001                                                  CAS: 108883     
PATHOLOGIST: J. SAGARTZ                                                        

                                      TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      338   416   472   473   589   602   614   618   622   625                 |
 |      625   631   645   652   663   672   673   676   677   701                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      29    283   478   570   572   577   614   618   624   625                 |
 |      670   681   686   688   689   698   698   698   711   711                 |
 |      713   722                                                                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1200 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 28     CENSORED DEATHS 10   TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      205   478   495   540   543   556   558   560   596   597                 |
 |      597   606   619   632   636   641   652   659   671   681                 |
 |      681   691   704   708   715   722   726   726                             |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                                      TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.3  96.7  92.6  92.6  88.6  70.5  60.4      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |    98.3  98.3  98.3  96.7  96.7  94.7  94.7  88.6  80.6  56.4      |
 |           |                                                                    |
 |           |                                                                    |
 |1200 PPM   |   100.0 100.0  98.3  98.3  98.3  96.3  90.3  78.3  64.2  44.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            600 PPM          1200 PPM      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       60.4%            56.4%            44.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.169          P=1.000          P=0.206       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       599.2            607.0            614.1         |
 |NATURAL DEATHS (C)      |       (21.7)           (34.8)           (20.2)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       640.7            639.2            630.3         |
 |(STANDARD ERROR)        |       (14.8)           (17.9)           (15.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                      TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 10   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      430   491   568   583   626   638   639   642   644   655                 |
 |      675   675   697   708   710   719   722                                   |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      414   457   537   540   553   554   653   653   658   676                 |
 |      679   681   681   711   717                                               |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1200 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 10   TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      165   421   561   563   564   584   606   606   630   640                 |
 |      648   648   652   654   667   673   693   706   708   723                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                                      TOLUENE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0 100.0  98.3  96.3  92.3  80.3  66.2      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0 100.0 100.0  98.3  96.7  92.6  88.6  82.6  70.5      |
 |           |                                                                    |
 |           |                                                                    |
 |1200 PPM   |   100.0  98.3  98.3  98.3  96.7  96.7  96.7  88.6  72.5  60.4      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            600 PPM          1200 PPM      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.2%            70.5%            60.4%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.519          P=0.843N         P=0.573       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       636.6            610.9            605.6         |
 |NATURAL DEATHS (C)      |       (19.5)           (24.4)           (27.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       657.7            654.4            642.8         |
 |(STANDARD ERROR)        |       (13.8)           (14.4)           (15.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                              TOLUENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        600 PPM          = 2
                                                        1200 PPM         = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1     2                          3                    1
      |       2                          3           2        1           1        12 3
      |                                                                             2 3       3   2
      |                                                                            1                  1
P  90 +                                                                                       3 3 22  11
E     |                                                                                            2   1 11
R     |                                                                                         3      3  22
C     |                                                                                                   11
E  80 +                                                                                                    2      2
N     |                                                                                                33 311 1   2 2
T     |                                                                                                   3 3 11    22
      |                                                                                                        1 1
S  70 +                                                                                                     33   11  22
U     |                                                                                                      3 3  11
R     |                                                                                                        3 33   2 2
V     |                                                                                                           313  1
I  60 +                                                                                                                1    1
V     |                                                                                                             33  2 2 2
A     |                                                                                                              3 33
L     |                                                                                                                 33
   50 +                                                                                                                  33
      |
      |                                                                                                                   3 3
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.

                                                              TOLUENE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        600 PPM          = 2
                                                        1200 PPM         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                         3                                       2 1
      |                           3                                       231    2    1
      |
      |                                                                    3     2    1      2   31
   95 +                                                                                      22
      |                                                                                           1 1
      |                                                                                       22    1      1
      |                                                                                        223  3
P  90 +                                                                                                    1 1
E     |                                                                                         2   3   3      2
R     |
C     |
E  85 +                                                                                                 3  3
N     |
T     |                                                                                                    3 1 1   2
      |
S  80 +                                                                                                      331   1
U     |                                                                                                            22
R     |
V     |                                                                                                       33   1  1
I  75 +                                                                                                             2   2
V     |                                                                                                               1 1
A     |                                                                                                        3  3     22
L     |
   70 +                                                                                                           33    11  2
      |                                                                                                            3 3   11
      |
      |                                                                                                              3 3  1 1
   65 +                                                                                                                33
      |
      |                                                                                                                 3 3
      |
   60 +                                                                                                                   3 3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

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