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TR 380 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          EPINEPHRINE HCL


NTP Experiment-Test: 05095-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55




       Facility:  Battelle Northwest

       Chemical CAS #:  55-31-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              11            7            9                                                  
    Moribund                                           7            8            7                                                  
  Survivors                                                                                                                         
    Moribund                                                                     1                                                  
    Terminal Sacrifice                                32           35           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (14)         (50)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (18)         (50)                                                
   Liver                                              (50)         (20)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hemangiosarcoma, Metastatic                      1 (2%)                                                                       
      Hepatocellular Carcinoma                         1 (2%)       1 (5%)       2 (4%)                                             
      Hepatocellular Adenoma                           2 (4%)       1 (5%)       4 (8%)                                             
      Hepatocholangiocarcinoma                                      1 (5%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                                       1 (5%)                                                          
   Pancreas                                           (50)         (16)         (50)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (6%)                                                          
   Salivary Glands                                    (49)         (14)         (49)                                                
   Stomach, Forestomach                               (50)         (19)         (49)                                                
      Squamous Cell Papilloma                                       1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (15)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (17)         (50)                                                
      Capsule, Adenoma                                                           1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (16)         (50)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (6%)                                                          
   Pituitary Gland                                    (49)         (46)         (49)                                                
      Adenoma                                          7 (14%)     11 (24%)     12 (24%)                                            
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (49)         (18)         (48)                                                
      Bilateral, Follicular Cell, Adenoma                           1 (6%)                                                          
      Follicular Cell, Adenocarcinoma                                            1 (2%)                                             
      Follicular Cell, Adenoma                         3 (6%)       1 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (26)         (50)                                                
      Adenocarcinoma                                                1 (4%)                                                          
      Adenoma                                                       1 (4%)                                                          
      Cystadenoma                                      3 (6%)                    1 (2%)                                             
      Hemangioma                                                    1 (4%)                                                          
      Teratoma                                         1 (2%)                                                                       
   Uterus                                             (50)         (19)         (50)                                                
      Adenocarcinoma                                                1 (5%)       2 (4%)                                             
      Adenoma                                          1 (2%)       1 (5%)                                                          
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyoma                                                     1 (5%)                                                          
      Sarcoma Stromal                                                            1 (2%)                                             
      Endometrium, Polyp Stromal                                    1 (5%)       3 (6%)                                             
   Vagina                                                                       (1)                                                 
      Sarcoma Stromal, Metastatic, Uterus                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (15)         (50)                                                
   Lymph Node                                         (50)         (29)         (49)                                                
   Lymph Node, Bronchial                              (45)         (20)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (49)         (19)         (45)                                                
   Spleen                                             (50)         (25)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                             1 (4%)                                                          
      Hemangiosarcoma, Metastatic, Skeletal Muscle                               1 (2%)                                             
   Thymus                                             (46)         (14)         (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (14)         (45)                                                
      Adenoacanthoma                                                             1 (2%)                                             
      Adenocarcinoma                                   1 (2%)                    2 (4%)                                             
   Skin                                               (49)         (23)         (49)                                                
      Subcutaneous Tissue, Hemangiosarcoma                          2 (9%)                                                          
      Subcutaneous Tissue, Mast Cell Tumor                                                                                          
          Malignant                                                 1 (4%)                                                          
      Vulva, Papilloma                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Hemangiosarcoma                                                            1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (15)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (14)         (50)                                                
   Lung                                               (50)         (27)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       5 (19%)                                                         
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Hemangiosarcoma, Metastatic                      1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (4%)                                                          
      Sarcoma, Metastatic, Liver                                    1 (4%)                                                          
   Nose                                               (50)         (48)         (50)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Turbinate, Hemangioma                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)                                                                           
      Adenocarcinoma                                   1 (50%)                                                                      
      Adenoma                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (19)         (50)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (5%)                                                          
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (50)         (15)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)       2 (4%)       7 (14%)                                            
      Lymphoma Malignant Mixed                        15 (30%)     15 (30%)      7 (14%)                                            
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          35          30                                                   
     Total Primary Neoplasms                           49          53          52                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 19          19          19                                                   
     Total Benign Neoplasms                            23          26          25                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          26          23                                                   
     Total Malignant Neoplasms                         26          27          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4           4                                                   
     Total Metastatic Neoplasm                          2           8           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              10            4            4                                                  
    Moribund                                           7           12           10                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           34           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (25)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       1 (4%)       1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                    1 (2%)                                             
      Hepatocellular Carcinoma                        11 (22%)      7 (28%)     10 (20%)                                            
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                          10 (20%)      5 (20%)      6 (12%)                                            
      Hepatocellular Adenoma, Multiple                              2 (8%)                                                          
      Histiocytic Sarcoma, Metastatic, Skin            1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (16)         (50)                                                
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                                                 1 (2%)                                             
      Squamous Cell Papilloma                                       1 (6%)                                                          
   Stomach, Glandular                                 (49)         (16)         (50)                                                
      Sarcoma, Poorly Differentiated                                1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (16)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (32)         (48)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (16)         (45)                                                
   Pituitary Gland                                    (50)         (16)         (48)                                                
   Thyroid Gland                                      (49)         (15)         (50)                                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (48)         (13)         (49)                                                
   Testes                                             (50)         (15)         (50)                                                
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (16)         (50)                                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                    1 (2%)                                             
      Calvarium, Mast Cell Tumor Malignant                                       1 (2%)                                             
   Lymph Node                                         (49)         (20)         (50)                                                
   Lymph Node, Bronchial                              (43)         (13)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                                                       
   Lymph Node, Mandibular                             (43)         (12)         (41)                                                
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                                                 1 (2%)                                             
   Spleen                                             (50)         (20)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       1 (5%)       3 (6%)                                             
      Hemangiosarcoma, Metastatic, Skin                2 (4%)                                                                       
      Mast Cell Tumor Malignant, Metastatic, Bone                                                                                   
          Marrow                                                                 1 (2%)                                             
   Thymus                                             (41)         (12)         (33)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (21)         (49)                                                
      Basal Cell Carcinoma                                          1 (5%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             2 (4%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (16)         (50)                                                
      Osteosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (16)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (32)         (50)                                                
      Alveolar/Bronchiolar Adenoma                    10 (20%)      8 (25%)      8 (16%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (3%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   5 (10%)      3 (9%)       5 (10%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                        1 (3%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                                                      1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       2 (6%)       2 (4%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Mediastinum, Hemangioma                                                    1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Respiratory Epithelium, Papilloma                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      Fibrosarcoma                                                  1 (100%)                                                        
   Eye                                                             (1)                                                              
      Fibrosarcoma                                                  1 (100%)                                                        
   Harderian Gland                                    (2)          (2)          (2)                                                 
      Adenoma                                          2 (100%)     1 (50%)      2 (100%)                                           
      Carcinoma                                                     1 (50%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (16)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (6%)                                                          
   Urinary Bladder                                    (50)         (16)         (50)                                                
                                                             Page   9                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                                1 (2%)       2 (4%)                                             
      Lymphoma Malignant Mixed                         7 (14%)      5 (10%)      3 (6%)                                             
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05095-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 00:50:55  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      1.5MG/M3     3.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          33          33                                                   
     Total Primary Neoplasms                           56          41          49                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          17          19                                                   
     Total Benign Neoplasms                            24          18          22                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          21          20                                                   
     Total Malignant Neoplasms                         32          23          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8           4           7                                                   
     Total Metastatic Neoplasm                         10           5           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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