National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1160

TR 380 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          EPINEPHRINE HCL


NTP Experiment-Test: 05095-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54




       Facility:  Battelle Northwest

       Chemical CAS #:  55-31-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           16           14                                                  
    Dead                                               4            5            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           29           30                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (45)         (18)         (44)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Liver                                              (50)         (31)         (47)                                                
      Neoplastic Nodule                                1 (2%)                    1 (2%)                                             
      Neoplastic Nodule, Multiple                      1 (2%)                                                                       
   Mesentery                                          (1)                       (2)                                                 
      Hemangioma                                       1 (100%)                                                                     
   Pancreas                                           (49)         (21)         (47)                                                
   Salivary Glands                                    (50)         (21)         (48)                                                
   Stomach, Forestomach                               (50)         (21)         (48)                                                
   Stomach, Glandular                                 (49)         (21)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (21)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (23)         (47)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (22)         (47)                                                
      Pheochromocytoma Benign                          1 (2%)       1 (5%)       4 (9%)                                             
   Islets, Pancreatic                                 (49)         (22)         (47)                                                
      Adenoma                                          1 (2%)                                                                       
      Adenoma, Multiple                                             1 (5%)                                                          
   Pituitary Gland                                    (49)         (38)         (47)                                                
      Pars Distalis, Adenoma                          30 (61%)     25 (66%)     32 (68%)                                            
      Pars Distalis, Carcinoma                         1 (2%)       1 (3%)       1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (21)         (47)                                                
      C-Cell, Adenoma                                  4 (8%)       3 (14%)      4 (9%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma, Multiple                                                  1 (2%)                                             
      C-Cell, Carcinoma                                2 (4%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (21)         (47)                                                
      Adenoma                                          5 (10%)      1 (5%)                                                          
      Carcinoma                                        2 (4%)       1 (5%)                                                          
   Ovary                                              (50)         (22)         (47)                                                
      Granulosa Cell Tumor NOS                                      1 (5%)                                                          
      Granulosa Cell Tumor Malignant                   2 (4%)                                                                       
   Uterus                                             (50)         (25)         (48)                                                
      Carcinoma                                                                  1 (2%)                                             
      Leiomyoma                                                     1 (4%)                                                          
      Endometrium, Deciduoma Malignant                 1 (2%)                                                                       
      Endometrium, Polyp                               1 (2%)                                                                       
      Endometrium, Polyp Stromal                       8 (16%)      4 (16%)      4 (8%)                                             
      Endometrium, Polyp Stromal, Multiple             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (21)         (47)                                                
   Lymph Node                                         (48)         (22)         (48)                                                
   Lymph Node, Bronchial                              (37)         (18)         (39)                                                
   Lymph Node, Mandibular                             (48)         (17)         (45)                                                
   Spleen                                             (50)         (26)         (47)                                                
   Thymus                                             (50)         (19)         (47)                                                
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (28)         (49)                                                
      Adenocarcinoma                                   2 (4%)       3 (11%)      4 (8%)                                             
      Fibroadenoma                                     9 (18%)     11 (39%)      9 (18%)                                            
      Fibroadenoma, Multiple                           1 (2%)                    2 (4%)                                             
   Skin                                               (48)         (22)         (48)                                                
      Fibroma                                          1 (2%)       1 (5%)       1 (2%)                                             
      Fibrous Histiocytoma                                          1 (5%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (21)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (21)         (49)                                                
      Carcinoma, Metastatic, Pituitary Gland                        1 (5%)                                                          
      Glioma NOS, Marked                                            1 (5%)                                                          
      Glioma NOS, Moderate                                                       1 (2%)                                             
      Oligodendroglioma Malignant                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (23)         (48)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (4%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Bronchus, Carcinoma                                                        1 (2%)                                             
   Nose                                               (50)         (50)         (46)                                                
      Respiratory Epithelium, Adenoma                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (23)         (48)                                                
   Urinary Bladder                                    (49)         (21)         (47)                                                
      Papilloma                                        2 (4%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            24 (48%)     18 (36%)     16 (32%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          41          43                                                   
     Total Primary Neoplasms                          105          76          87                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          35          38                                                   
     Total Benign Neoplasms                            70          49          59                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          22          23                                                   
     Total Malignant Neoplasms                         35          25          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1                                                               
     Total Metastatic Neoplasm                          1           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              2           1                                                   
     Total Uncertain Neoplasms                                      2           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          17           17           13                                                  
    Dead                                                            6            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           26           32                                                  
    Moribund                                                        1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (24)         (49)                                                
   Intestine Large, Cecum                             (49)         (22)         (46)                                                
   Intestine Large, Colon                             (50)         (20)         (47)                                                
   Intestine Large, Rectum                            (50)         (20)         (45)                                                
   Intestine Small, Duodenum                          (50)         (21)         (47)                                                
   Intestine Small, Ileum                             (49)         (19)         (44)                                                
   Intestine Small, Jejunum                           (50)         (20)         (45)                                                
   Liver                                              (50)         (33)         (49)                                                
      Neoplastic Nodule                                1 (2%)       1 (3%)                                                          
   Mesentery                                          (5)          (5)          (2)                                                 
      Sarcoma                                                       1 (20%)                                                         
      Schwannoma NOS                                                1 (20%)                                                         
   Pancreas                                           (50)         (23)         (49)                                                
   Salivary Glands                                    (50)         (24)         (49)                                                
   Stomach, Forestomach                               (49)         (26)         (48)                                                
      Sarcoma                                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (25)         (48)                                                
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (24)         (50)                                                
      Schwannoma NOS                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (23)         (49)                                                
      Osteosarcoma, Metastatic, Bone                                1 (4%)                                                          
   Adrenal Gland, Medulla                             (50)         (25)         (48)                                                
      Pheochromocytoma Malignant                                    1 (4%)       1 (2%)                                             
      Pheochromocytoma Benign                          9 (18%)      2 (8%)      14 (29%)                                            
      Pheochromocytoma Benign, Multiple                2 (4%)       1 (4%)       2 (4%)                                             
   Islets, Pancreatic                                 (50)         (24)         (49)                                                
      Adenoma                                          5 (10%)      1 (4%)       1 (2%)                                             
      Carcinoma                                        1 (2%)       1 (4%)                                                          
   Parathyroid Gland                                  (43)         (19)         (37)                                                
   Pituitary Gland                                    (50)         (36)         (48)                                                
      Pars Distalis, Adenoma                          34 (68%)     29 (81%)     25 (52%)                                            
      Pars Distalis, Carcinoma                                      1 (3%)                                                          
   Thyroid Gland                                      (50)         (24)         (49)                                                
      C-Cell, Adenoma                                  7 (14%)      2 (8%)       5 (10%)                                            
      C-Cell, Adenoma, Multiple                        2 (4%)       1 (4%)                                                          
      C-Cell, Carcinoma                                4 (8%)       2 (8%)                                                          
      Follicular Cell, Carcinoma                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (46)         (27)         (39)                                                
   Preputial Gland                                    (49)         (25)         (49)                                                
      Adenoma                                          3 (6%)                    2 (4%)                                             
      Carcinoma                                                     1 (4%)       2 (4%)                                             
   Prostate                                           (50)         (25)         (49)                                                
      Adenoma                                                                    1 (2%)                                             
   Seminal Vesicle                                    (50)         (24)         (49)                                                
   Testes                                             (50)         (47)         (50)                                                
      Interstitial Cell, Adenoma                      14 (28%)     10 (21%)      8 (16%)                                            
      Interstitial Cell, Adenoma, Multiple            25 (50%)     22 (47%)     34 (68%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (23)         (49)                                                
   Lymph Node                                         (50)         (28)         (50)                                                
   Lymph Node, Bronchial                              (44)         (22)         (45)                                                
   Lymph Node, Mandibular                             (48)         (24)         (42)                                                
   Spleen                                             (50)         (32)         (49)                                                
                                                             Page   7                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Osteosarcoma, Metastatic, Bone                                1 (3%)                                                          
   Thymus                                             (46)         (22)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (35)         (20)         (41)                                                
      Fibroadenoma                                     2 (6%)                    1 (2%)                                             
   Skin                                               (50)         (26)         (50)                                                
      Fibroma                                          5 (10%)                   1 (2%)                                             
      Keratoacanthoma                                  2 (4%)                    1 (2%)                                             
      Lipoma                                                                     1 (2%)                                             
      Papilloma                                                                  2 (4%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Trichoepithelioma                                1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (24)         (50)                                                
      Osteosarcoma                                                  1 (4%)                                                          
   Skeletal Muscle                                    (2)          (1)          (1)                                                 
      Osteosarcoma, Metastatic, Bone                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (24)         (50)                                                
      Oligodendroglioma Benign                         1 (2%)       1 (4%)                                                          
      Cerebrum, Astrocytoma NOS                                                  1 (2%)                                             
   Spinal Cord                                                     (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (29)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (3%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Preputial Gland                                     1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (3%)                                                          
   Nose                                               (50)         (49)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)          (1)                                                 
      Neurofibroma                                                               1 (100%)                                           
   Eye                                                (4)          (3)          (3)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (26)         (49)                                                
      Pelvis, Transitional Epithelium, Carcinoma                                 1 (2%)                                             
   Urinary Bladder                                    (50)         (22)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Monocytic                                            1 (2%)                                                          
      Leukemia Mononuclear                            19 (38%)     21 (42%)     22 (44%)                                            
      Mesothelioma Malignant                           1 (2%)       2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05095-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          EPINEPHRINE HCL                                      Date: 09/12/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:29:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1.5MG/M3     5.0MG/M3                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          50                                                   
     Total Primary Neoplasms                          150         104         133                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          47          50                                                   
     Total Benign Neoplasms                           119          71         102                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          27          26                                                   
     Total Malignant Neoplasms                         30          32          30                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                                   
     Total Metastatic Neoplasm                                      4           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           1                                                   
     Total Uncertain Neoplasms                          1           1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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