National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3023

TR 381 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              CARVONE


NTP Experiment-Test: 05032-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 19:21:15




       Facility:  International Research and Development Corp.

       Chemical CAS #:  99490

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          23            9            4                                                  
    Dead                                              13           10            7                                                  
    Accident                                                        2            1                                                  
  Survivors                                                                                                                         
    Moribund                                                        1                                                               
    Terminal Sacrifice                                14           28           38                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (49)                                                
      Perforation, Focal                                            1 (2%)       1 (2%)                                             
      Mucosa, Muscularis, Inflammation, Acute,                                                                                      
           Diffuse                                     1 (2%)                                                                       
      Periesophageal Tissue, Abscess, Focal            1 (2%)                                                                       
      Periesophageal Tissue, Abscess, Multifocal       2 (4%)                                                                       
      Periesophageal Tissue, Inflammation, Chronic                  1 (2%)                                                          
   Gallbladder                                        (31)         (34)         (42)                                                
      Infiltration Cellular, Diffuse, Lymphocyte       1 (3%)       1 (3%)       1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte                      2 (6%)       2 (5%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    2 (6%)       1 (3%)       1 (2%)                                             
      Inflammation, Acute, Diffuse                     1 (3%)                    1 (2%)                                             
      Inflammation, Acute, Focal                                    3 (9%)       1 (2%)                                             
   Intestine Large, Cecum                             (46)         (44)         (46)                                                
      Ulcer, Diffuse                                                1 (2%)                                                          
      Lymphoid Nodule, Hyperplasia, Focal, Lymphoid                              1 (2%)                                             
      Lymphoid Nodule, Hyperplasia, Lymphoid,                                                                                       
          Multifocal                                                             1 (2%)                                             
      Wall, Abscess, Multifocal                                     1 (2%)                                                          
   Intestine Large, Rectum                            (47)         (45)         (45)                                                
      Inflammation, Acute, Focal                       5 (11%)     15 (33%)     22 (49%)                                            
   Intestine Small, Jejunum                           (41)         (40)         (47)                                                
      Peyer's Patch, Hyperplasia, Diffuse, Lymphoid                              1 (2%)                                             
      Peyer's Patch, Hyperplasia, Focal, Lymphoid                                2 (4%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid,                                                                                         
          Multifocal                                                1 (3%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Fatty Change, Diffuse                                                      1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal    18 (36%)     12 (24%)      1 (2%)                                             
      Hypertrophy, Focal                                                         1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         3 (6%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Multifocal, Lymphocyte    2 (4%)       4 (8%)       4 (8%)                                             
      Inflammation, Acute, Multifocal                  1 (2%)                    2 (4%)                                             
      Bile Duct, Infiltration Cellular, Multifocal,                                                                                 
           Lymphocyte                                  3 (6%)       4 (8%)       5 (10%)                                            
      Bile Duct, Mineralization, Multifocal                         1 (2%)                                                          
      Hepatocyte, Focal Cellular Change                                          1 (2%)                                             
      Serosa, Abscess, Focal                           1 (2%)                                                                       
      Serosa, Inflammation, Acute, Focal                            1 (2%)                                                          
      Serosa, Inflammation, Acute, Multifocal          2 (4%)                                                                       
      Serosa, Inflammation, Chronic, Focal             1 (2%)                                                                       
   Mesentery                                          (20)         (12)         (2)                                                 
      Abscess, Focal                                   1 (5%)                                                                       
      Abscess, Multifocal                             19 (95%)      8 (67%)                                                         
      Cyst, Single                                                  1 (8%)                                                          
      Inflammation, Acute, Multifocal                                            1 (50%)                                            
      Inflammation, Granulomatous, Multifocal                       1 (8%)                                                          
      Pigmentation, Diffuse                                         1 (8%)                                                          
      Fat, Necrosis, Multifocal                                                  1 (50%)                                            
   Pancreas                                           (49)         (49)         (49)                                                
      Abscess, Multifocal                              3 (6%)       1 (2%)                                                          
      Atrophy, Diffuse                                 1 (2%)                    1 (2%)                                             
      Atrophy, Focal                                   1 (2%)                    3 (6%)                                             
      Atrophy, Multifocal                              2 (4%)                                                                       
      Inflammation, Acute, Diffuse                     4 (8%)       1 (2%)                                                          
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Inflammation, Acute, Multifocal                  2 (4%)                                                                       
      Inflammation, Chronic, Diffuse                   1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       5 (10%)      2 (4%)                                             
      Inflammation, Chronic, Multifocal                4 (8%)       1 (2%)       1 (2%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)                                                                       
      Duct, Cyst, Single                                                         2 (4%)                                             
      Duct, Dilatation                                 1 (2%)                    1 (2%)                                             
      Duct, Inflammation, Chronic, Focal                            1 (2%)       2 (4%)                                             
      Duct, Inflammation, Chronic, Multifocal                       1 (2%)       3 (6%)                                             
   Salivary Glands                                    (49)         (45)         (50)                                                
      Infiltration Cellular, Focal, Lymphocyte         4 (8%)       5 (11%)      9 (18%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte   11 (22%)      8 (18%)     17 (34%)                                            
   Stomach, Forestomach                               (47)         (47)         (49)                                                
      Abscess, Focal                                   1 (2%)       1 (2%)       1 (2%)                                             
      Abscess, Multifocal                                                        1 (2%)                                             
      Acanthosis, Focal                                5 (11%)      2 (4%)       7 (14%)                                            
      Acanthosis, Multifocal                           1 (2%)                                                                       
      Cyst Epithelial Inclusion, Focal                              1 (2%)       1 (2%)                                             
      Hyperkeratosis, Focal                            1 (2%)       3 (6%)       1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Inflammation, Acute, Focal                       1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic, Focal                     5 (11%)      3 (6%)       1 (2%)                                             
   Stomach, Glandular                                 (48)         (49)         (50)                                                
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Multifocal                               1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (49)         (50)                                                
      Aorta, Media, Mineralization, Diffuse            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)                                                
      Artery, Inflammation, Chronic, Focal             1 (2%)       3 (6%)                                                          
      Atrium Left, Bacterium, Focal                                              1 (2%)                                             
      Atrium Left, Thrombosis                                       1 (2%)       1 (2%)                                             
      Epicardium, Inflammation, Acute, Diffuse         1 (2%)                                                                       
      Epicardium, Inflammation, Acute, Focal           1 (2%)                                                                       
      Epicardium, Inflammation, Acute, Multifocal      3 (6%)                                                                       
      Epicardium, Inflammation, Chronic, Diffuse       1 (2%)                                                                       
      Epicardium, Inflammation, Chronic, Focal                      2 (4%)                                                          
      Epicardium, Inflammation, Chronic, Multifocal    1 (2%)                                                                       
      Myocardium, Inflammation, Acute, Diffuse                      1 (2%)                                                          
      Myocardium, Inflammation, Acute, Focal           1 (2%)                                                                       
      Myocardium, Inflammation, Chronic, Focal                                   2 (4%)                                             
      Myocardium, Inflammation, Chronic, Multifocal                 1 (2%)                                                          
      Pericardium, Inflammation, Chronic, Focal                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Capsule, Inflammation, Chronic, Multifocal                    1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Cyst, Multiple                                                             1 (2%)                                             
      Cyst, Single                                     1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation, Diffuse        2 (4%)                                                                       
      Hematopoietic Cell Proliferation, Focal          1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)       1 (2%)       1 (2%)                                             
      Hypertrophy, Focal                                            1 (2%)       1 (2%)                                             
      Bilateral, Hematopoietic Cell Proliferation,                                                                                  
           Diffuse                                     1 (2%)       1 (2%)                                                          
      Bilateral, Hematopoietic Cell Proliferation,                                                                                  
           Multifocal                                  9 (18%)      2 (4%)                                                          
      Bilateral, Vacuolization Cytoplasmic, Diffuse    2 (4%)       1 (2%)       1 (2%)                                             
      Bilateral, Spindle Cell, Hyperplasia, Diffuse   32 (64%)     33 (67%)     39 (78%)                                            
      Bilateral, Spindle Cell, Hyperplasia,                                                                                         
          Multifocal                                  16 (32%)     10 (20%)      7 (14%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Spindle Cell, Hyperplasia, Diffuse               1 (2%)       4 (8%)       3 (6%)                                             
      Spindle Cell, Hyperplasia, Multifocal            1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (48)         (50)                                                
      Hematopoietic Cell Proliferation, Focal                       1 (2%)                                                          
   Pituitary Gland                                    (46)         (49)         (48)                                                
      Hypertrophy, Focal                               1 (2%)       1 (2%)       1 (2%)                                             
      Craniopharyngeal Duct, Cyst                                   1 (2%)                                                          
   Thyroid Gland                                      (49)         (46)         (50)                                                
      Granuloma, Focal                                 1 (2%)                                                                       
      Hyperplasia, Multifocal                                       1 (2%)                                                          
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)       1 (2%)                                                          
      Ultimobranchial Cyst                            13 (27%)     18 (39%)      4 (8%)                                             
      Follicle, Cyst                                   1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (48)         (48)                                                
      Abscess, Focal                                   4 (8%)                                                                       
      Abscess, Multifocal                             16 (32%)      7 (15%)                                                         
      Cyst, Multiple                                   1 (2%)                    1 (2%)                                             
      Cyst, Single                                     7 (14%)      4 (8%)      10 (21%)                                            
      Mineralization, Focal                                         2 (4%)                                                          
      Bilateral, Abscess, Multifocal                   6 (12%)      2 (4%)       1 (2%)                                             
      Bilateral, Cyst, Multiple                        2 (4%)       1 (2%)       1 (2%)                                             
      Germinal Epithelium, Hyperplasia, Focal                       1 (2%)                                                          
      Periovarian Tissue, Inflammation, Chronic,                                                                                    
           Diffuse                                                  1 (2%)                                                          
   Oviduct                                                         (1)                                                              
      Inflammation, Acute, Diffuse                                  1 (100%)                                                        
   Uterus                                             (50)         (50)         (50)                                                
      Abscess, Focal                                   1 (2%)       1 (2%)                                                          
      Abscess, Multifocal                              9 (18%)      2 (4%)                                                          
      Dilatation                                       5 (10%)      7 (14%)     14 (28%)                                            
      Inflammation, Acute, Diffuse                     3 (6%)       3 (6%)                                                          
      Endometrium, Edema, Diffuse                                   1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic, Diffuse       14 (28%)     26 (52%)     27 (54%)                                            
      Endometrium, Hyperplasia, Cystic, Multifocal     1 (2%)       1 (2%)       1 (2%)                                             
      Lumen, Exudate                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hypoplasia, Diffuse                              1 (2%)                                                                       
      Myelofibrosis, Focal                             2 (4%)                                                                       
      Myeloid Cell, Hyperplasia, Diffuse               6 (12%)      4 (8%)       1 (2%)                                             
   Lymph Node                                         (47)         (47)         (48)                                                
      Bronchial, Abscess, Focal                        1 (2%)                                                                       
      Bronchial, Hyperplasia, Diffuse, Lymphoid        1 (2%)                                                                       
      Bronchial, Infiltration Cellular, Diffuse,                                                                                    
           Plasma Cell                                 1 (2%)                                                                       
      Iliac, Hyperplasia, Lymphoid, Multifocal         1 (2%)                                                                       
      Iliac, Infiltration Cellular, Diffuse,                                                                                        
          Plasma Cell                                  4 (9%)       1 (2%)                                                          
      Inguinal, Infiltration Cellular, Diffuse,                                                                                     
           Plasma Cell                                 2 (4%)                                                                       
      Mediastinal, Abscess, Focal                      1 (2%)                                                                       
      Mediastinal, Abscess, Multifocal                              1 (2%)                                                          
      Mediastinal, Hyperplasia, Diffuse, Lymphoid                   1 (2%)                                                          
      Mediastinal, Infiltration Cellular, Diffuse,                                                                                  
           Plasma Cell                                 1 (2%)                                                                       
      Renal, Infiltration Cellular, Diffuse,                                                                                        
          Plasma Cell                                  4 (9%)       1 (2%)                                                          
   Lymph Node, Mandibular                             (7)          (15)                                                             
      Hyperplasia, Diffuse, Lymphoid                   1 (14%)                                                                      
      Hyperplasia, Focal, Lymphoid                                  1 (7%)                                                          
      Hyperplasia, Lymphoid, Multifocal                2 (29%)      8 (53%)                                                         
      Infiltration Cellular, Diffuse, Plasma Cell      4 (57%)      7 (47%)                                                         
      Sinus, Ectasia, Diffuse                          1 (14%)                                                                      
   Lymph Node, Mesenteric                             (46)         (47)         (48)                                                
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       1 (2%)                                                          
      Hyperplasia, Diffuse, Lymphoid                   1 (2%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Diffuse, Re Cell                    7 (15%)      1 (2%)       1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                     2 (4%)                                                                       
      Hyperplasia, Lymphoid, Multifocal                2 (4%)       3 (6%)      14 (29%)                                            
      Infiltration Cellular, Diffuse, Plasma Cell      2 (4%)       1 (2%)                                                          
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Necrosis, Caseous, Diffuse                       1 (2%)                                                                       
   Spleen                                             (50)         (49)         (50)                                                
      Depletion Lymphoid, Diffuse                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation, Diffuse       32 (64%)     18 (37%)      7 (14%)                                            
      Hyperplasia, Diffuse, Lymphoid                   4 (8%)       3 (6%)      16 (32%)                                            
      Hyperplasia, Lymphoid, Multifocal                1 (2%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Multifocal, Re Cell                                           1 (2%)                                             
      Pigmentation, Diffuse                            6 (12%)      3 (6%)       3 (6%)                                             
      Artery, Trabecula, Amyloid Deposition,                                                                                        
          Multifocal                                   1 (2%)                                                                       
      Capsule, Inflammation, Acute, Diffuse            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Capsule, Inflammation, Acute, Multifocal         1 (2%)                                                                       
      Capsule, Inflammation, Chronic, Diffuse          1 (2%)                                                                       
      Capsule, Inflammation, Chronic, Focal                         2 (4%)                                                          
   Thymus                                             (35)         (42)         (46)                                                
      Abscess, Focal                                                1 (2%)                                                          
      Abscess, Multifocal                              1 (3%)                                                                       
      Atrophy, Diffuse                                17 (49%)     13 (31%)      6 (13%)                                            
      Hyperplasia, Focal, Lymphoid                                  1 (2%)       2 (4%)                                             
      Hyperplasia, Focal, Re Cell                                                1 (2%)                                             
      Hyperplasia, Lymphoid, Multifocal                2 (6%)                                                                       
      Mediastinum, Abscess, Focal                      1 (3%)                                                                       
      Mediastinum, Abscess, Multifocal                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (46)         (42)                                                
      Hyperplasia, Diffuse                            16 (33%)      8 (17%)      3 (7%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
   Skin                                               (16)         (34)         (14)                                                
      Acanthosis, Diffuse                                           2 (6%)       1 (7%)                                             
      Acanthosis, Focal                                1 (6%)                    2 (14%)                                            
      Acanthosis, Multifocal                           1 (6%)       3 (9%)       8 (57%)                                            
      Hyperkeratosis, Diffuse                                       1 (3%)       1 (7%)                                             
      Hyperkeratosis, Focal                                         1 (3%)                                                          
      Hyperkeratosis, Multifocal                                    2 (6%)                                                          
      Inflammation, Acute, Multifocal                                            1 (7%)                                             
      Inflammation, Chronic, Diffuse                                5 (15%)      2 (14%)                                            
      Inflammation, Chronic, Focal                                  1 (3%)                                                          
      Inflammation, Chronic, Multifocal                             1 (3%)       1 (7%)                                             
      Ulcer, Focal                                                               1 (7%)                                             
      Back, Subcutaneous Tissue, Abscess, Focal        1 (6%)                                                                       
      Hair Follicle, Acanthosis, Diffuse                                         1 (7%)                                             
      Hair Follicle, Atrophy, Diffuse                  3 (19%)      3 (9%)       6 (43%)                                            
      Hair Follicle, Atrophy, Focal                    1 (6%)                                                                       
      Hair Follicle, Atrophy, Multifocal                                         1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Femur, Fibrous Osteodystrophy, Diffuse           3 (6%)                                                                       
      Femur, Fracture Healed                                        1 (2%)                                                          
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Inflammation, Acute, Diffuse                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Bilateral, Thalamus, Mineralization,                                                                                          
          Multifocal                                  12 (24%)     17 (35%)     15 (30%)                                            
      Meninges, Abscess, Focal                         1 (2%)                                                                       
      Meninges, Inflammation, Acute, Focal             1 (2%)                                                                       
      Meninges, Cerebrum, Abscess, Multifocal                       1 (2%)                                                          
      Thalamus, Hemorrhage, Multifocal                              1 (2%)                                                          
      Thalamus, Mineralization, Focal                  3 (6%)       3 (6%)       4 (8%)                                             
      Thalamus, Mineralization, Multifocal             5 (10%)      6 (12%)      6 (12%)                                            
      Ventricle, Abscess, Multifocal                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Abscess, Multifocal                              1 (2%)       2 (4%)                                                          
      Bacterium, Multifocal                            1 (2%)                                                                       
      Congestion, Multifocal                           1 (2%)                                                                       
      Hemorrhage, Diffuse                                           1 (2%)                                                          
      Hemorrhage, Focal                                2 (4%)                                                                       
      Hemorrhage, Multifocal                           2 (4%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                                                          
      Alveolus, Inflammation, Acute, Focal                                       1 (2%)                                             
      Artery, Adventitia, Inflammation, Chronic,                                                                                    
           Multifocal                                  1 (2%)                                                                       
      Artery, Media, Hypertrophy, Multifocal           4 (8%)                                                                       
      Peribronchial, Infiltration Cellular,                                                                                         
          Diffuse, Lymphocyte                                       1 (2%)       1 (2%)                                             
      Peribronchial, Infiltration Cellular,                                                                                         
          Multifocal, Lymphocyte                      30 (60%)     28 (56%)     35 (70%)                                            
      Peribronchiolar, Infiltration Cellular,                                                                                       
          Multifocal, Lymphocyte                       2 (4%)                    2 (4%)                                             
      Perivascular, Infiltration Cellular, Diffuse,                                                                                 
           Lymphocyte                                  1 (2%)                    1 (2%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Lymphocyte                      16 (32%)     23 (46%)      8 (16%)                                            
      Pleura, Foreign Body, Focal                      1 (2%)                    1 (2%)                                             
      Pleura, Granuloma, Focal                         1 (2%)                                                                       
      Pleura, Inflammation, Acute, Diffuse             1 (2%)                                                                       
      Pleura, Inflammation, Acute, Multifocal                                    1 (2%)                                             
      Pleura, Inflammation, Chronic, Diffuse                        1 (2%)                                                          
   Nose                                               (49)         (49)         (50)                                                
      Foreign Body                                    35 (71%)     35 (71%)     33 (66%)                                            
      Hyperplasia, Focal, Lymphoid                                               1 (2%)                                             
      Glands, Hyperplasia                             19 (39%)     45 (92%)     49 (98%)                                            
      Nasolacrimal Duct, Exudate, Diffuse              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Atrophy                   25 (51%)     46 (94%)     49 (98%)                                            
      Turbinate, Exudate                              15 (31%)     22 (45%)     17 (34%)                                            
      Turbinate, Fungus, Focal                                                   1 (2%)                                             
      Turbinate, Fungus, Multifocal                    1 (2%)                                                                       
      Turbinate, Hemorrhage, Diffuse                                2 (4%)                                                          
      Turbinate, Hemorrhage, Focal                     1 (2%)                                                                       
      Turbinate, Hemorrhage, Multifocal                             1 (2%)                                                          
      Turbinate, Inflammation, Acute, Diffuse          2 (4%)                    2 (4%)                                             
      Turbinate, Inflammation, Acute, Focal                                      1 (2%)                                             
      Turbinate, Inflammation, Acute, Multifocal       5 (10%)     22 (45%)     39 (78%)                                            
      Turbinate, Inflammation, Chronic, Diffuse        1 (2%)      10 (20%)      3 (6%)                                             
      Turbinate, Inflammation, Chronic, Focal          1 (2%)       4 (8%)       2 (4%)                                             
      Turbinate, Inflammation, Chronic, Multifocal    29 (59%)     17 (35%)     16 (32%)                                            
      Turbinate, Ulcer, Focal                          1 (2%)                                                                       
   Trachea                                            (49)         (50)         (50)                                                
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Chronic, Diffuse                   3 (6%)       3 (6%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     2 (4%)       5 (10%)      1 (2%)                                             
      Inflammation, Chronic, Multifocal                6 (12%)      7 (14%)     10 (20%)                                            
      Peritracheal Tissue, Abscess, Multifocal         1 (2%)                                                                       
      Peritracheal Tissue, Foreign Body, Focal                                   1 (2%)                                             
      Peritracheal Tissue, Hemorrhage, Focal                                     1 (2%)                                             
      Peritracheal Tissue, Inflammation, Acute,                                                                                     
           Focal                                       1 (2%)                                                                       
      Peritracheal Tissue, Inflammation, Chronic,                                                                                   
           Diffuse                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst, Multiple                                   1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       2 (4%)       4 (8%)                                             
      Inflammation, Chronic, Multifocal                2 (4%)      10 (20%)      7 (14%)                                            
      Bilateral, Abscess, Multifocal                   1 (2%)                                                                       
      Bilateral, Glomerulosclerosis, Diffuse           2 (4%)       1 (2%)                                                          
      Bilateral, Hematopoietic Cell Proliferation,                                                                                  
           Diffuse                                                  1 (2%)                                                          
      Bilateral, Inflammation, Chronic, Diffuse        1 (2%)                                                                       
      Bilateral, Inflammation, Chronic, Multifocal    33 (66%)     21 (42%)     21 (42%)                                            
      Bilateral, Cortex, Abscess, Multifocal                        1 (2%)                                                          
      Bilateral, Pelvis, Bacterium, Multifocal         1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Bilateral, Renal Tubule, Bacterium,                                                                                           
          Multifocal                                                1 (2%)                                                          
      Bilateral, Renal Tubule, Casts Protein,                                                                                       
          Multifocal                                                1 (2%)                                                          
      Bilateral, Renal Tubule, Mineralization,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Bilateral, Renal Tubule, Pigmentation,                                                                                        
          Multifocal                                                2 (4%)                                                          
      Bilateral, Renal Tubule, Regeneration,                                                                                        
          Multifocal                                                1 (2%)                                                          
      Capsule, Interstitial Tissue, Inflammation,                                                                                   
           Chronic                                                  1 (2%)                                                          
      Glomerulus, Renal Tubule, Amyloid Deposition,                                                                                 
           Diffuse                                     1 (2%)                                                                       
      Interstitial Tissue, Renal Tubule,                                                                                            
          Pigmentation, Multifocal                     1 (2%)                                                                       
      Left, Hydronephrosis                             1 (2%)                                                                       
      Pelvis, Bacterium, Focal                         1 (2%)                                                                       
      Pelvis, Bacterium, Multifocal                    1 (2%)       1 (2%)       1 (2%)                                             
      Pelvis, Concretion, Multifocal                   1 (2%)                                                                       
      Renal Tubule, Bacterium, Multifocal              1 (2%)                                                                       
      Renal Tubule, Casts Protein, Multifocal          1 (2%)                                                                       
      Renal Tubule, Degeneration, Focal                3 (6%)                                                                       
      Renal Tubule, Degeneration, Multifocal                        1 (2%)                                                          
      Renal Tubule, Regeneration, Focal                1 (2%)       1 (2%)                                                          
      Renal Tubule, Regeneration, Multifocal           2 (4%)                                                                       
   Ureter                                                                       (1)                                                 
      Dilatation                                                                 1 (100%)                                           
   Urinary Bladder                                    (46)         (46)         (48)                                                
      Abscess, Focal                                   1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         4 (9%)       6 (13%)      5 (10%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte   16 (35%)     22 (48%)     19 (40%)                                            
      Serosa, Inflammation, Chronic, Multifocal                     1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            6            7                                                  
    Moribund                                           7            2            3                                                  
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           42           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)                                                
      Perforation, Focal                                            1 (2%)                                                          
      Periesophageal Tissue, Hemorrhage, Focal                                   1 (2%)                                             
      Periesophageal Tissue, Inflammation, Acute,                                                                                   
           Diffuse                                                               1 (2%)                                             
   Gallbladder                                        (38)         (36)         (43)                                                
      Infiltration Cellular, Diffuse, Lymphocyte       4 (11%)      2 (6%)       1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (3%)       3 (8%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    1 (3%)       1 (3%)                                                          
      Inflammation, Acute, Diffuse                     1 (3%)       4 (11%)                                                         
      Inflammation, Acute, Focal                                                 1 (2%)                                             
   Intestine Large, Cecum                             (50)         (46)         (49)                                                
      Lymphoid Nodule, Hyperplasia, Focal, Lymphoid                 1 (2%)                                                          
      Lymphoid Nodule, Hyperplasia, Lymphoid,                                                                                       
          Multifocal                                                1 (2%)                                                          
   Intestine Large, Rectum                            (48)         (45)         (44)                                                
      Inflammation, Acute, Focal                      19 (40%)     15 (33%)     18 (41%)                                            
   Intestine Small, Duodenum                          (48)         (47)         (46)                                                
      Peyer's Patch, Hyperplasia, Lymphoid,                                                                                         
          Multifocal                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (48)         (48)         (48)                                                
      Peyer's Patch, Hyperplasia, Focal, Lymphoid                   1 (2%)       2 (4%)                                             
   Liver                                              (50)         (50)         (49)                                                
      Basophilic Focus                                 1 (2%)                                                                       
      Cyst, Multiple                                   1 (2%)                                                                       
      Fatty Change, Multifocal                                      1 (2%)       1 (2%)                                             
      Infarct, Focal                                   2 (4%)                    1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte                 3 (6%)                                                          
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Necrosis, Coagulative, Diffuse                   1 (2%)                                                                       
      Necrosis, Coagulative, Multifocal                                          2 (4%)                                             
      Bile Duct, Infiltration Cellular, Multifocal,                                                                                 
           Lymphocyte                                  1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (1)                                                                           
      Inflammation, Acute, Diffuse                     1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (48)                                                
      Abscess, Focal                                   1 (2%)                                                                       
      Atrophy, Focal                                   2 (4%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       7 (14%)                                                         
      Inflammation, Chronic, Multifocal                2 (4%)       2 (4%)                                                          
      Necrosis, Focal                                  1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal            1 (2%)       1 (2%)                                                          
      Artery, Media, Mineralization, Multifocal                                  1 (2%)                                             
      Duct, Inflammation, Chronic, Focal                                         1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
      Infiltration Cellular, Focal, Lymphocyte         5 (10%)     10 (20%)      7 (14%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte   17 (34%)     25 (50%)     11 (22%)                                            
   Stomach, Forestomach                               (48)         (48)         (47)                                                
      Abscess, Focal                                   4 (8%)       3 (6%)                                                          
      Abscess, Multifocal                              1 (2%)       3 (6%)                                                          
      Acanthosis, Focal                                2 (4%)       3 (6%)       5 (11%)                                            
      Acanthosis, Multifocal                           2 (4%)       2 (4%)       6 (13%)                                            
      Cyst Epithelial Inclusion, Focal                 1 (2%)                    1 (2%)                                             
      Hyperkeratosis, Focal                                         2 (4%)                                                          
      Inflammation, Acute, Focal                                    1 (2%)       1 (2%)                                             
      Inflammation, Acute, Multifocal                                            1 (2%)                                             
      Inflammation, Chronic, Focal                     2 (4%)                    6 (13%)                                            
      Inflammation, Chronic, Multifocal                1 (2%)                    1 (2%)                                             
      Serosa, Inflammation, Acute, Diffuse             1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (49)         (48)                                                
      Inflammation, Acute, Focal                                                 2 (4%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Artery, Adventitia, Inflammation, Chronic,                                                                                    
           Multifocal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (50)         (50)                                                
      Mesenteric Artery, Aorta, Adventitia,                                                                                         
          Inflammation, Chronic, Multifocal            1 (2%)                                                                       
      Mesenteric Artery, Aorta, Media, Hypertrophy,                                                                                 
           Multifocal                                  1 (2%)                                                                       
      Mesenteric Artery, Renal Artery, Adventitia,                                                                                  
           Inflammation, Chronic, Multifocal           1 (2%)                                                                       
      Mesenteric Artery, Renal Artery, Media,                                                                                       
          Hypertrophy, Diffuse                         1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)                                                
      Artery, Inflammation, Chronic, Diffuse           2 (4%)       1 (2%)                                                          
      Endocardium, Inflammation, Acute, Focal                                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Endocardium, Inflammation, Chronic, Focal        1 (2%)                                                                       
      Epicardium, Inflammation, Acute, Diffuse         2 (4%)                    1 (2%)                                             
      Epicardium, Inflammation, Acute, Focal           1 (2%)                    2 (4%)                                             
      Ventricle Left, Myocardium, Hemorrhage, Focal                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Hypertrophy, Focal                               1 (2%)       3 (6%)       2 (4%)                                             
      Bilateral, Hypertrophy, Multifocal                            1 (2%)                                                          
      Bilateral, Spindle Cell, Hyperplasia, Diffuse                 1 (2%)                                                          
      Bilateral, Spindle Cell, Hyperplasia, Focal      1 (2%)                                                                       
      Bilateral, Spindle Cell, Hyperplasia,                                                                                         
          Multifocal                                  25 (50%)     30 (60%)     23 (46%)                                            
      Spindle Cell, Hyperplasia, Diffuse                                         1 (2%)                                             
      Spindle Cell, Hyperplasia, Focal                 9 (18%)      8 (16%)      5 (10%)                                            
      Spindle Cell, Hyperplasia, Multifocal           11 (22%)      6 (12%)      4 (8%)                                             
   Adrenal Gland, Medulla                             (48)         (49)         (48)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (47)         (49)                                                
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
   Parathyroid Gland                                  (27)         (27)         (26)                                                
      Cyst, Single                                                  1 (4%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         1 (4%)                                                                       
   Pituitary Gland                                    (40)         (48)         (48)                                                
      Hypertrophy, Focal                               1 (3%)                                                                       
      Craniopharyngeal Duct, Cyst                      1 (3%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)                                                
      Hyperplasia, Cystic, Focal                                    1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
      Ultimobranchial Cyst                             5 (10%)      9 (18%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Atypia Cellular, Multifocal                      1 (2%)                    1 (2%)                                             
      Granuloma Sperm, Focal                                        1 (2%)                                                          
      Inflammation, Chronic, Focal                     4 (8%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Spermatocele                                                  1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                    2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                                           1 (2%)                                             
      Bilateral, Atypia Cellular, Multifocal                                     4 (8%)                                             
      Bilateral, Inflammation, Chronic, Multifocal                  1 (2%)                                                          
      Bilateral, Vacuolization Cytoplasmic, Diffuse    1 (2%)                    1 (2%)                                             
      Bilateral, Vacuolization Cytoplasmic,                                                                                         
          Multifocal                                   1 (2%)       1 (2%)                                                          
      Serosa, Inflammation, Acute, Diffuse             1 (2%)                                                                       
   Penis                                              (1)                                                                           
      Inflammation, Focal                              1 (100%)                                                                     
   Preputial Gland                                    (10)         (4)          (3)                                                 
      Abscess, Focal                                   4 (40%)                   1 (33%)                                            
      Abscess, Multifocal                              1 (10%)      1 (25%)                                                         
      Dilatation                                       1 (10%)      1 (25%)      1 (33%)                                            
      Inflammation, Chronic, Diffuse                   3 (30%)      1 (25%)      1 (33%)                                            
      Inflammation, Chronic, Multifocal                1 (10%)                                                                      
      Bilateral, Abscess, Multifocal                                2 (50%)                                                         
      Bilateral, Dilatation                            1 (10%)                                                                      
   Prostate                                           (49)         (49)         (49)                                                
      Abscess, Multifocal                              1 (2%)                                                                       
      Infiltration Cellular, Focal, Lymphocyte         3 (6%)       4 (8%)       2 (4%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Diffuse                     2 (4%)                                                                       
   Seminal Vesicle                                    (1)                                                                           
      Abscess, Multifocal                              1 (100%)                                                                     
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Seminiferous Tubule, Degeneration,                                                                                 
           Diffuse                                                  1 (2%)                                                          
      Bilateral, Seminiferous Tubule,                                                                                               
          Vacuolization Cytoplasmic, Diffuse           2 (4%)       3 (6%)       1 (2%)                                             
      Seminiferous Tubule, Degeneration, Diffuse       1 (2%)       1 (2%)       1 (2%)                                             
      Seminiferous Tubule, Degeneration, Focal         1 (2%)       1 (2%)       1 (2%)                                             
      Seminiferous Tubule, Mineralization, Focal                    1 (2%)                                                          
      Seminiferous Tubule, Mineralization,                                                                                          
          Multifocal                                                1 (2%)                                                          
      Seminiferous Tubule, Vacuolization                                                                                            
          Cytoplasmic, Diffuse                                                   2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
      Erythroid Cell, Hyperplasia, Diffuse                                       1 (2%)                                             
      Myeloid Cell, Hyperplasia, Diffuse               2 (4%)                                                                       
   Lymph Node                                         (50)         (50)         (49)                                                
      Axillary, Hyperplasia, Lymphoid, Multifocal      2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inguinal, Hyperplasia, Diffuse, Lymphoid         1 (2%)                                                                       
      Inguinal, Hyperplasia, Lymphoid, Multifocal                   1 (2%)                                                          
      Inguinal, Pigmentation, Diffuse                  1 (2%)                                                                       
      Inguinal, Pigmentation, Focal                                 1 (2%)                                                          
      Inguinal, Pigmentation, Multifocal                                         1 (2%)                                             
      Renal, Hyperplasia, Lymphoid, Multifocal         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (48)                                                
      Hematopoietic Cell Proliferation, Diffuse        3 (6%)       7 (14%)                                                         
      Hematopoietic Cell Proliferation, Focal          1 (2%)                                                                       
      Hyperplasia, Diffuse, Lymphoid                  12 (24%)      1 (2%)       1 (2%)                                             
      Hyperplasia, Diffuse, Re Cell                    2 (4%)                                                                       
      Hyperplasia, Focal, Lymphoid                     3 (6%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid, Multifocal               11 (22%)      7 (14%)     10 (21%)                                            
      Infiltration Cellular, Diffuse, Plasma Cell      1 (2%)                                                                       
      Inflammation, Acute, Diffuse                     1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid,                                                                                           
          Multifocal                                                             1 (2%)                                             
   Spleen                                             (50)         (50)         (48)                                                
      Hematopoietic Cell Proliferation, Diffuse        9 (18%)      3 (6%)       6 (13%)                                            
      Hyperplasia, Diffuse, Lymphoid                   4 (8%)       2 (4%)       2 (4%)                                             
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Hyperplasia, Lymphoid, Multifocal               12 (24%)     11 (22%)     10 (21%)                                            
      Pigmentation, Diffuse                            1 (2%)                                                                       
   Thymus                                             (44)         (42)         (44)                                                
      Atrophy, Diffuse                                 6 (14%)      8 (19%)      5 (11%)                                            
      Cyst, Single                                     1 (2%)                                                                       
      Hyperplasia, Diffuse, Lymphoid                                             1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Mineralization, Multifocal                                    1 (2%)                                                          
      Mediastinum, Abscess, Focal                      1 (2%)                                                                       
      Mediastinum, Hemorrhage, Focal                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (5)          (4)          (6)                                                 
      Inflammation, Chronic, Multifocal                1 (20%)                                                                      
   Skin                                               (26)         (45)         (15)                                                
      Acanthosis, Focal                                4 (15%)      1 (2%)                                                          
      Acanthosis, Multifocal                           3 (12%)                   5 (33%)                                            
      Cyst Epithelial Inclusion, Single                1 (4%)                                                                       
      Hyperkeratosis, Focal                            3 (12%)      1 (2%)                                                          
      Hyperkeratosis, Multifocal                       2 (8%)                    1 (7%)                                             
      Inflammation, Acute, Multifocal                  1 (4%)                                                                       
      Inflammation, Chronic, Diffuse                   3 (12%)                   1 (7%)                                             
      Inflammation, Chronic, Focal                     2 (8%)       2 (4%)       1 (7%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic, Multifocal                2 (8%)                                                                       
      Ulcer, Focal                                     5 (19%)                                                                      
      Artery, Subcutaneous Tissue, Adventitia,                                                                                      
           Inflammation, Chronic, Focal                1 (4%)                                                                       
      Artery, Subcutaneous Tissue, Adventitia,                                                                                      
           Inflammation, Chronic, Multifocal           1 (4%)                                                                       
      Back, Ulcer, Focal                                                         1 (7%)                                             
      Hair Follicle, Atrophy, Diffuse                  3 (12%)                   1 (7%)                                             
      Hair Follicle, Atrophy, Focal                                              3 (20%)                                            
      Hair Follicle, Inflammation, Chronic,                                                                                         
          Multifocal                                   1 (4%)                                                                       
      Neck, Edema, Diffuse                                                       1 (7%)                                             
      Prepuce, Acanthosis, Diffuse                                               1 (7%)                                             
      Prepuce, Cyst Epithelial Inclusion, Focal        1 (4%)                                                                       
      Prepuce, Inflammation, Chronic, Diffuse                                    1 (7%)                                             
      Subcutaneous Tissue, Edema, Diffuse                           2 (4%)                                                          
      Subcutaneous Tissue, Head, Granuloma, Focal      1 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Bilateral, Thalamus, Mineralization,                                                                                          
          Multifocal                                  23 (46%)     20 (40%)     22 (44%)                                            
      Cerebellum, Hemorrhage, Multifocal                                         1 (2%)                                             
      Lateral Ventricle, Meninges, Abscess,                                                                                         
          Multifocal                                   1 (2%)                                                                       
      Olfactory Lobe, Mineralization, Focal                                      1 (2%)                                             
      Thalamus, Mineralization, Focal                  2 (4%)       1 (2%)                                                          
      Thalamus, Mineralization, Multifocal             5 (10%)      9 (18%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                                                       (1)                                                 
      Hemorrhage                                                                 1 (100%)                                           
   Lung                                               (50)         (50)         (50)                                                
      Congestion, Diffuse                                                        1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage, Focal                                1 (2%)       2 (4%)                                                          
      Hemorrhage, Multifocal                                        2 (4%)       3 (6%)                                             
      Thrombosis, Diffuse                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    1 (2%)                                             
      Alveolar Epithelium, Hypertrophy, Focal                       4 (8%)       1 (2%)                                             
      Alveolus, Foreign Body, Multifocal                                         1 (2%)                                             
      Peribronchial, Infiltration Cellular,                                                                                         
          Multifocal, Lymphocyte                      29 (58%)     32 (64%)     21 (42%)                                            
      Peribronchiolar, Infiltration Cellular,                                                                                       
          Multifocal, Lymphocyte                       1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Lymphocyte                       4 (8%)       5 (10%)      1 (2%)                                             
      Pleura, Inflammation, Acute, Diffuse             1 (2%)                                                                       
      Pleura, Inflammation, Acute, Multifocal          1 (2%)                                                                       
      Pleura, Inflammation, Chronic, Focal                          1 (2%)                                                          
   Nose                                               (50)         (50)         (49)                                                
      Foreign Body                                    25 (50%)     23 (46%)     26 (53%)                                            
      Glands, Hyperplasia                              3 (6%)      42 (84%)     44 (90%)                                            
      Nasolacrimal Duct, Inflammation, Chronic,                                                                                     
           Diffuse                                                               1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic,                                                                                     
           Focal                                       1 (2%)                                                                       
      Olfactory Epithelium, Atrophy                   11 (22%)     42 (84%)     44 (90%)                                            
      Turbinate, Congestion, Diffuse                                             1 (2%)                                             
      Turbinate, Exudate                               9 (18%)     10 (20%)      8 (16%)                                            
      Turbinate, Foreign Body                                                    1 (2%)                                             
      Turbinate, Hemorrhage, Diffuse                                             6 (12%)                                            
      Turbinate, Hemorrhage, Focal                                  1 (2%)                                                          
      Turbinate, Inflammation, Acute, Diffuse                                    1 (2%)                                             
      Turbinate, Inflammation, Acute, Focal                         1 (2%)       2 (4%)                                             
      Turbinate, Inflammation, Acute, Multifocal                    3 (6%)      27 (55%)                                            
      Turbinate, Inflammation, Chronic, Diffuse        1 (2%)       6 (12%)      1 (2%)                                             
      Turbinate, Inflammation, Chronic, Focal          6 (12%)      2 (4%)                                                          
      Turbinate, Inflammation, Chronic, Multifocal     9 (18%)      3 (6%)       6 (12%)                                            
   Trachea                                            (50)         (50)         (49)                                                
      Inflammation, Chronic, Diffuse                  10 (20%)      8 (16%)                                                         
      Inflammation, Chronic, Focal                     1 (2%)       2 (4%)                                                          
      Inflammation, Chronic, Multifocal               10 (20%)      5 (10%)     11 (22%)                                            
      Peritracheal Tissue, Foreign Body, Multifocal                              1 (2%)                                             
      Peritracheal Tissue, Hemorrhage, Diffuse                      1 (2%)       1 (2%)                                             
      Peritracheal Tissue, Hemorrhage, Multifocal                                1 (2%)                                             
      Peritracheal Tissue, Inflammation, Acute,                                                                                     
           Multifocal                                                            1 (2%)                                             
      Peritracheal Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                                 1 (2%)                                             
      Peritracheal Tissue, Inflammation, Chronic,                                                                                   
           Multifocal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Bacterium, Multifocal                            1 (2%)                                                                       
      Casts Protein, Diffuse                           1 (2%)                                                                       
      Cyst, Multiple                                                             1 (2%)                                             
      Cyst, Single                                     1 (2%)       4 (8%)       1 (2%)                                             
      Hydronephrosis                                   1 (2%)                                                                       
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Inflammation, Chronic, Focal                     2 (4%)       5 (10%)      7 (14%)                                            
      Inflammation, Chronic, Multifocal                3 (6%)       3 (6%)       3 (6%)                                             
      Bilateral, Cyst, Multiple                                                  1 (2%)                                             
      Bilateral, Inflammation, Acute, Focal            1 (2%)                                                                       
      Bilateral, Inflammation, Chronic, Focal          1 (2%)                                                                       
      Bilateral, Inflammation, Chronic, Multifocal    29 (58%)     25 (50%)     19 (39%)                                            
      Bilateral, Artery, Inflammation, Chronic,                                                                                     
           Multifocal                                  1 (2%)                                                                       
      Bilateral, Renal Tubule, Casts Protein,                                                                                       
          Multifocal                                   1 (2%)                                                                       
      Bilateral, Renal Tubule, Concretion,                                                                                          
          Multifocal                                   1 (2%)       2 (4%)                                                          
      Bilateral, Renal Tubule, Degeneration,                                                                                        
          Multifocal                                   1 (2%)       2 (4%)       1 (2%)                                             
      Bilateral, Renal Tubule, Regeneration,                                                                                        
          Multifocal                                   2 (4%)       2 (4%)       2 (4%)                                             
      Bilateral, Renal Tubule, Vacuolization                                                                                        
          Cytoplasmic, Multifocal                      1 (2%)                                                                       
      Interstitial Tissue, Inflammation, Chronic,                                                                                   
           Diffuse                                     1 (2%)                                                                       
      Renal Tubule, Casts Protein, Diffuse             1 (2%)                                                                       
      Renal Tubule, Concretion, Multifocal             1 (2%)                                                                       
      Renal Tubule, Degeneration, Focal                1 (2%)       4 (8%)       1 (2%)                                             
      Renal Tubule, Degeneration, Multifocal           2 (4%)                    1 (2%)                                             
      Renal Tubule, Regeneration, Focal                             2 (4%)       3 (6%)                                             
      Renal Tubule, Regeneration, Multifocal           2 (4%)       4 (8%)                                                          
      Renal Tubule, Vacuolization Cytoplasmic,                                                                                      
           Multifocal                                               1 (2%)                                                          
   Ureter                                             (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
   Urethra                                            (1)                                                                           
      Mucosa, Inflammation, Acute, Diffuse             1 (100%)                                                                     
   Urinary Bladder                                    (50)         (47)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Dilatation                                       1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         3 (6%)       3 (6%)       3 (6%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte   13 (26%)      6 (13%)      3 (6%)                                             
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia, Diffuse    1 (2%)                                                                       
      Transitional Epithelium, Vacuolization                                                                                        
          Cytoplasmic, Diffuse                         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.