National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3031

TR 381 Mouse Pathology Tables

NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97
Route: GAVAGE                                                                                                     Time: 13:44:01




       Facility:  International Research and Development Corp.

       Chemical CAS #:  99490

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Muscularis, Inflammation,    |                                                                          |             
           Acute, Diffuse                  |                                                                          |             
      Periesophageal Tissue, Abscess, Focal|                                                                          |             
      Periesophageal Tissue, Abscess,      |                                                                          |             
          Multifocal                       |                                                          2               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  M  +  +  +  +  +  A  +  M  +  A  M  +  +  A  +  A  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       1                    2                                             |             
      Inflammation, Acute, Diffuse         |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |       1                 1  1                                1            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                      1  1                          1                 2   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |       2                                   1              3               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                       2                  |             
      Inflammation, Acute, Multifocal      |          2                                                               |             
      Bile Duct, Infiltration Cellular,    |                                                                          |             
           Multifocal, Lymphocyte          |             1           2  2                                             |             
      Serosa, Abscess, Focal               |                                                                          |             
      Serosa, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Serosa, Inflammation, Chronic, Focal |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +  +  +     +     +     +   |             
      Abscess, Focal                       |                                                                          |             
      Abscess, Multifocal                  |                                              4  4  2     4     4     4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                                                 4                        |             
      Atrophy, Diffuse                     |                                                          4               |             
      Atrophy, Focal                       |                      4                                                   |             
      Atrophy, Multifocal                  |                                                    1                     |             
      Inflammation, Acute, Diffuse         |                                              4                 2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                    1                     |             
      Inflammation, Chronic, Focal         |                                        1                                 |             
      Inflammation, Chronic, Multifocal    |       2                                   1                              |             
      Necrosis, Multifocal                 | 2                                                                        |             
      Duct, Dilatation                     | 4                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                     1  1                                 |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       2     1              3              3           3  2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                                                                          |             
      Acanthosis, Focal                    |                      3                 2  3                              |             
      Acanthosis, Multifocal               |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         |                      3                 1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Media, Mineralization, Diffuse|                               2                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic, Focal |                                                    3                     |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Diffuse                         |                                                                          |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                2         |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Multifocal                      |                               2              2                           |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Diffuse                         |                                                                          |             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                         2                                                |             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Cyst, Single                         |                            1                                             |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                 1                    1   |             
      Bilateral, Hematopoietic Cell        |                                                                          |             
          Proliferation, Diffuse           |                                              3                           |             
      Bilateral, Hematopoietic Cell        |                                                                          |             
          Proliferation, Multifocal        |                      1                                   2               |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Diffuse                         |                                  3                                       |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Diffuse                         |    2  2  3  3  2  2  3     2        2  2     2  2  2  2  2              2|             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Multifocal                      |                         1     2  2        2                 2  2  2      |             
      Spindle Cell, Hyperplasia, Diffuse   | 2                                                                        |             
      Spindle Cell, Hyperplasia, Multifocal|                                                                      2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  M  M  +  M  +  +  +  M  M  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Hypertrophy, Focal                   |          1                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Focal                     |                                                    3                     |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         |          1                                                               |             
      Ultimobranchial Cyst                 |    X     X  X              X        X                          X  X      |             
      Follicle, Cyst                       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                      4                                         2         |             
      Abscess, Multifocal                  |                   4           4              4                       4   |             
      Cyst, Multiple                       |                                                                          |             
      Cyst, Single                         | 1     1     3  3                 2                                       |             
      Bilateral, Abscess, Multifocal       |                                                 4  4     4               |             
      Bilateral, Cyst, Multiple            |                            3           2                                 |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Abscess, Focal                       |                                                                          |             
      Abscess, Multifocal                  |                   4                          4                       4   |             
      Dilatation                           |          3                       2                       2               |             
      Inflammation, Acute, Diffuse         |                         2                       4  2                     |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Diffuse                         |    2  2     1           2  4           2  3           1                 2|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Multifocal                      |                                     2                                    |             
      Lumen, Exudate                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia, Diffuse                  |                                                                      3   |             
      Myelofibrosis, Focal                 |                   2                                      2               |             
      Myeloid Cell, Hyperplasia, Diffuse   |                      2              2        2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Bronchial, Abscess, Focal            |                                                                      4   |             
      Bronchial, Hyperplasia, Diffuse,     |                                                                          |             
           Lymphoid                        |                                                             2            |             
      Bronchial, Infiltration Cellular,    |                                                                          |             
           Diffuse, Plasma Cell            |                                                                      3   |             
      Iliac, Hyperplasia, Lymphoid,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Iliac, Infiltration Cellular,        |                                                                          |             
          Diffuse, Plasma Cell             |                                                          3           3   |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Diffuse, Plasma Cell            |                                              3                 3         |             
      Mediastinal, Abscess, Focal          |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Diffuse, Plasma Cell            |                                                                      3   |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Diffuse, Plasma Cell             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +  +     +  +                                            +   |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |             2  2                                                         |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Plasma Cell                      |             3  3        3                                                |             
      Sinus, Ectasia, Diffuse              |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |             
      Hyperplasia, Diffuse, Re Cell        |                               2                 3                        |             
      Hyperplasia, Focal, Lymphoid         |                                                          1     1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |       2                                                                  |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Necrosis, Caseous, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid, Diffuse          |                                  2                                       |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |             1        2  1     3     1        3  3  2     3     1     3   |             
      Hyperplasia, Diffuse, Lymphoid       |       2              2                    2                              |             
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |             
      Pigmentation, Diffuse                | 2              2  2                                         1     1      |             
      Artery, Trabecula, Amyloid           |                                                                          |             
          Deposition, Multifocal           |                                                                   2      |             
      Capsule, Inflammation, Acute, Diffuse|                                                                          |             
      Capsule, Inflammation, Acute,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Diffuse                          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                                                    4                     |             
      Atrophy, Diffuse                     | 3              3                 4           1  4        4     3  3  3   |             
      Hyperplasia, Lymphoid, Multifocal    |             1                                                            |             
      Mediastinum, Abscess, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 | 1                 1           2  2                 1              1      |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +     +  +  +  +                              |             
      Acanthosis, Focal                    |                      2                                                   |             
      Acanthosis, Multifocal               |                         1                                                |             
      Back, Subcutaneous Tissue, Abscess,  |                                                                          |             
           Focal                           |                                                                          |             
      Hair Follicle, Atrophy, Diffuse      |                3  2                                                      |             
      Hair Follicle, Atrophy, Focal        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy,       |                                                                          |             
          Diffuse                          |                               2                          2        3      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Thalamus, Mineralization, |                                                                          |             
           Multifocal                      |       1  1  1        1                                   2  1           1|             
      Meninges, Abscess, Focal             |                                     4                                    |             
      Meninges, Inflammation, Acute, Focal |                                     4                                    |             
      Thalamus, Mineralization, Focal      |    1              1                                                      |             
      Thalamus, Mineralization, Multifocal |                                           1                              |             
      Ventricle, Abscess, Multifocal       |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                                                                          |             
      Bacterium, Multifocal                |                                                                      3   |             
      Congestion, Multifocal               | 1                                                                        |             
      Hemorrhage, Focal                    |                      1                                                   |             
      Hemorrhage, Multifocal               |                                                             1            |             
      Alveolar Epithelium, Hyperplasia     |                                                                         2|             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic, Multifocal             |                                                    3                     |             
      Artery, Media, Hypertrophy,          |                                                                          |             
          Multifocal                       |                   2                                3        3            |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Multifocal, Lymphocyte          |    1  2  2  2     1  2  2  3        2  2  3     1     3  2           3  2|             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Multifocal, Lymphocyte |                                                             3            |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Diffuse, Lymphocyte             |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |                            3     2  2  2                    3            |             
      Pleura, Foreign Body, Focal          |                                                                          |             
      Pleura, Granuloma, Focal             |                                                                          |             
      Pleura, Inflammation, Acute, Diffuse |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          1  1  2  1  2  2     1  2  2     1  1     2     1  1  2  2     1|             
      Glands, Hyperplasia                  |    1     2  1        1  1                          1                     |             
      Nasolacrimal Duct, Exudate, Diffuse  | 2                                                                        |             
      Olfactory Epithelium, Atrophy        |    1     3  3        3  2        2  2     2        2  2                  |             
      Turbinate, Exudate                   |          3  3  2     2  3           2              2           2         |             
      Turbinate, Fungus, Multifocal        |                                                                   3      |             
      Turbinate, Hemorrhage, Focal         |                                                                          |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
          Diffuse                          |                                                                          |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |    1                    1                                         2      |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |             3                                                            |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Focal                           |                                                                          |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |    2  1  2        1  2  2  2     2  3     1        2  1  1        1      |             
      Turbinate, Ulcer, Focal              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |             1              1                                             |             
      Inflammation, Chronic, Focal         |    1                                                                     |             
      Inflammation, Chronic, Multifocal    |                      1  1              1                 1               |             
      Peritracheal Tissue, Abscess,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   A                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                   3      |             
      Inflammation, Chronic, Focal         |                                                                2         |             
      Inflammation, Chronic, Multifocal    |    2                                                                     |             
      Bilateral, Abscess, Multifocal       |                                                                          |             
      Bilateral, Glomerulosclerosis,       |                                                                          |             
          Diffuse                          |                               4                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |                               3                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |       2  1  2        2  1  2        1  1  2        1  2  1           1   |             
      Bilateral, Pelvis, Bacterium,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Glomerulus, Renal Tubule, Amyloid    |                                                                          |             
          Deposition, Diffuse              |                                                                   4      |             
      Interstitial Tissue, Renal Tubule,   |                                                                          |             
           Pigmentation, Multifocal        |                                                                   1      |             
      Left, Hydronephrosis                 |                                                                          |             
      Pelvis, Bacterium, Focal             |                                                                      3   |             
      Pelvis, Bacterium, Multifocal        |                                                                          |             
      Pelvis, Concretion, Multifocal       |                                                                      2   |             
      Renal Tubule, Bacterium, Multifocal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|             
                             DAY ON TEST   | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|             
                                           | 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Casts Protein,         |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Renal Tubule, Degeneration, Focal    |                                           3                              |             
      Renal Tubule, Regeneration, Focal    |                                                                          |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                     1                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       2  2              1  4           2  2           1  2           3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Muscularis, Inflammation,    |                                                                          |            |
           Acute, Diffuse                  |          3                                                               |      1  3.0|
      Periesophageal Tissue, Abscess, Focal|                         4                                                |      1  4.0|
      Periesophageal Tissue, Abscess,      |                                                                          |            |
          Multifocal                       |                                        4                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  A  A  M  +  +  +  +  A  +  +  +  M  +  A  M  +  M  A  +  +  A  +  M|  31        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |    2                                                                     |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  1.5|
      Inflammation, Acute, Diffuse         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M|  47        |
      Inflammation, Acute, Focal           |                                           1                              |      5  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A|  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    1  3  1     2        2  2  1        2     2     1     2     2  2     2|     18  1.7|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      3  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                         2                                                |      2  2.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Bile Duct, Infiltration Cellular,    |                                                                          |            |
           Multifocal, Lymphocyte          |                                                                          |      3  1.7|
      Serosa, Abscess, Focal               |                                                                   4      |      1  4.0|
      Serosa, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                4                                               3         |      2  3.5|
      Serosa, Inflammation, Chronic, Focal |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +     +     +     +  +              +  +  +     +     +  +     +|  20        |
      Abscess, Focal                       |                                                 3                        |      1  3.0|
      Abscess, Multifocal                  | 3     4  4     4     4     3  4              4     4     4     4  4     4|     19  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Abscess, Multifocal                  |                      4                             3                     |      3  3.7|
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
      Atrophy, Focal                       |                                                                          |      1  4.0|
      Atrophy, Multifocal                  |    2                                                                     |      2  1.5|
      Inflammation, Acute, Diffuse         |                4              2                                          |      4  3.0|
      Inflammation, Acute, Multifocal      | 3     2                                                                  |      2  2.5|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |    1                                                           1         |      4  1.3|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Duct, Dilatation                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                        3                 1               |      4  1.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1                       1        2     2           2                  |     11  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Abscess, Focal                       |                                     2                                    |      1  2.0|
      Acanthosis, Focal                    |                                     3     2                              |      5  2.6|
      Acanthosis, Multifocal               |                                                                      2   |      1  2.0|
      Hyperkeratosis, Focal                |                                           1                              |      1  1.0|
      Inflammation, Acute, Focal           |                   2                                                      |      1  2.0|
      Inflammation, Chronic, Focal         |                                     2     2                             3|      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Inflammation, Acute, Focal           |                                              3                           |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Media, Mineralization, Diffuse|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic, Focal |                                                                          |      1  3.0|
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Diffuse                         |                                              3                           |      1  3.0|
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Multifocal                      | 2                                                                        |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Diffuse                         |                                                                1         |      1  1.0|
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Single                         |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |       2                                            1                     |      2  1.5|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                               1                                          |      1  1.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      2  1.0|
      Bilateral, Hematopoietic Cell        |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  3.0|
      Bilateral, Hematopoietic Cell        |                                                                          |            |
          Proliferation, Multifocal        |          1     2     2     2                 2           1              1|      9  1.6|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Diffuse                         |                                                 2                        |      2  2.5|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Diffuse                         | 2  3     2        2        2     2  3  2  3  3     2     2  2  3     2  2|     32  2.3|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Multifocal                      |       2     2  2     2  2     2                 2     2           2      |     16  1.9|
      Spindle Cell, Hyperplasia, Diffuse   |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia, Multifocal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  M  M  M  +  M  M  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  46        |
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Granuloma, Focal                     |                                                                          |      1  3.0|
      Inflammation, Acute, Focal           |                   1                                                      |      1  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |       X        X                    X           X        X     X         |     13     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Focal                       |       4                                      4                           |      4  3.5|
      Abscess, Multifocal                  | 4  4     4  4        4  4     4        4           4     4     4        4|     16  4.0|
      Cyst, Multiple                       |                                                 3                        |      1  3.0|
      Cyst, Single                         |    2                                                                 3   |      7  2.1|
      Bilateral, Abscess, Multifocal       |                4           4                                      4      |      6  4.0|
      Bilateral, Cyst, Multiple            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                M         |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Focal                       |          4                                                               |      1  4.0|
      Abscess, Multifocal                  |             4  4     4  3                       4                       4|      9  3.9|
      Dilatation                           |                                        2  3                              |      5  2.4|
      Inflammation, Acute, Diffuse         |                                                                          |      3  2.7|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Diffuse                         |    1                          2     2              2     2               |     14  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Lumen, Exudate                       |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypoplasia, Diffuse                  |                                                                          |      1  3.0|
      Myelofibrosis, Focal                 |                                                                          |      2  2.0|
      Myeloid Cell, Hyperplasia, Diffuse   |    2           2                                                  2      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Bronchial, Abscess, Focal            |                                                                          |      1  4.0|
      Bronchial, Hyperplasia, Diffuse,     |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
      Bronchial, Infiltration Cellular,    |                                                                          |            |
           Diffuse, Plasma Cell            |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid,        |                                                                          |            |
          Multifocal                       |    3                                                                     |      1  3.0|
      Iliac, Infiltration Cellular,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Diffuse, Plasma Cell             |                         2                                      2         |      4  2.5|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Diffuse, Plasma Cell            |                                                                          |      2  3.0|
      Mediastinal, Abscess, Focal          |                                        4                                 |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Diffuse, Plasma Cell            |                                                                          |      1  3.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Diffuse, Plasma Cell             |                            3           4                                3|      4  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                     +                             +      |   7        |
      Hyperplasia, Diffuse, Lymphoid       |                                     2                                    |      1  2.0|
      Hyperplasia, Lymphoid, Multifocal    |                                                                          |      2  2.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Plasma Cell                      |                                                                   3      |      4  3.0|
      Sinus, Ectasia, Diffuse              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                   2      |      1  2.0|
      Hyperplasia, Diffuse, Lymphoid       |                                     2                                    |      1  2.0|
      Hyperplasia, Diffuse, Re Cell        | 2     2              2        2                             2            |      7  2.1|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      2  1.0|
      Hyperplasia, Lymphoid, Multifocal    |                                           1                              |      2  1.5|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Plasma Cell                      |                            3                                   2         |      2  2.5|
      Inflammation, Acute, Focal           |                               1                                          |      1  1.0|
      Necrosis, Caseous, Diffuse           |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid, Diffuse          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         | 2  3  2  2  2  3     3  2  3  1  3     2     3  1  2  1  2  2  3  4     3|     32  2.3|
      Hyperplasia, Diffuse, Lymphoid       |                         1                                                |      4  1.8|
      Hyperplasia, Lymphoid, Multifocal    |                                           2                              |      1  2.0|
      Pigmentation, Diffuse                |                   2                                                      |      6  1.7|
      Artery, Trabecula, Amyloid           |                                                                          |            |
          Deposition, Multifocal           |                                                                          |      1  2.0|
      Capsule, Inflammation, Acute, Diffuse| 4                                                                        |      1  4.0|
      Capsule, Inflammation, Acute,        |                                                                          |            |
          Multifocal                       |                4                                                         |      1  4.0|
      Capsule, Inflammation, Chronic,      |                                                                          |            |
          Diffuse                          |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  M  +  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  +  M  M  M|  35        |
      Abscess, Multifocal                  |                                                                          |      1  4.0|
      Atrophy, Diffuse                     |       2        2  4        3                    4  2        3  3         |     17  3.0|
      Hyperplasia, Lymphoid, Multifocal    |                                           1                              |      2  1.0|
      Mediastinum, Abscess, Focal          |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hyperplasia, Diffuse                 | 2     2                 1              1           2  1  2     2  1  1   |     16  1.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                        +     +  +  +  +           +     +|  16        |
      Acanthosis, Focal                    |                                                                          |      1  2.0|
      Acanthosis, Multifocal               |                                                                          |      1  1.0|
      Back, Subcutaneous Tissue, Abscess,  |                                                                          |            |
           Focal                           |                                                                   4      |      1  4.0|
      Hair Follicle, Atrophy, Diffuse      |                                              3                           |      3  2.7|
      Hair Follicle, Atrophy, Focal        |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fibrous Osteodystrophy,       |                                                                          |            |
          Diffuse                          |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   1        |
      Inflammation, Acute, Diffuse         |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Thalamus, Mineralization, |                                                                          |            |
           Multifocal                      |       1                    1           1              1  1               |     12  1.1|
      Meninges, Abscess, Focal             |                                                                          |      1  4.0|
      Meninges, Inflammation, Acute, Focal |                                                                          |      1  4.0|
      Thalamus, Mineralization, Focal      |                                                                      1   |      3  1.0|
      Thalamus, Mineralization, Multifocal |          1  1                                      1              1      |      5  1.0|
      Ventricle, Abscess, Multifocal       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Multifocal                  |                                              4                           |      1  4.0|
      Bacterium, Multifocal                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Congestion, Multifocal               |                                                                          |      1  1.0|
      Hemorrhage, Focal                    |                            2                                             |      2  1.5|
      Hemorrhage, Multifocal               |                                                                      2   |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Artery, Adventitia, Inflammation,    |                                                                          |            |
           Chronic, Multifocal             |                                                                          |      1  3.0|
      Artery, Media, Hypertrophy,          |                                                                          |            |
          Multifocal                       |             2                                                            |      4  2.5|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Multifocal, Lymphocyte          | 2  2     2              2  1  1     3  2  3           1  1     2  2  1   |     30  1.9|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Multifocal, Lymphocyte |                                  1                                       |      2  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Diffuse, Lymphocyte             |             2                                                            |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          | 2     2        2     3           1  2  1  3           1     1           2|     16  2.0|
      Pleura, Foreign Body, Focal          |                                                 1                        |      1  1.0|
      Pleura, Granuloma, Focal             |                                                 1                        |      1  1.0|
      Pleura, Inflammation, Acute, Diffuse |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         | 2  2  2     2  2     2  2  1  2     3  2     1        2  1     2  2  1  1|     35  1.6|
      Glands, Hyperplasia                  | 1  2  1              1  1     1     1  1  2                 1  2  2     1|     19  1.3|
      Nasolacrimal Duct, Exudate, Diffuse  |                                                                          |      1  2.0|
      Olfactory Epithelium, Atrophy        | 2  3  4     1        3  4  1  3     2  2  3                 3  3  4     2|     25  2.5|
      Turbinate, Exudate                   |    3           2     2        2     3                 1           1      |     15  2.2|
      Turbinate, Fungus, Multifocal        |                                                                          |      1  3.0|
      Turbinate, Hemorrhage, Focal         |                                        3                                 |      1  3.0|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Diffuse                          |                                                 4        1               |      2  2.5|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Multifocal                       | 1  1                                                                     |      5  1.2|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Focal                           |                1                                                         |      1  1.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      | 2  2  2              2  3  4  2     3  2  1           2     2  1     1  1|     29  1.8|
      Turbinate, Ulcer, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Diffuse       |                         2                                                |      3  1.3|
      Inflammation, Chronic, Focal         |                                                                      1   |      2  1.0|
      Inflammation, Chronic, Multifocal    |       1                                   1                              |      6  1.0|
      Peritracheal Tissue, Abscess,        |                                                                          |            |
          Multifocal                       |                      4                                                   |      1  4.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Acute, Focal                    | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                          +      |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Multiple                       |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Inflammation, Chronic, Multifocal    |                                                          2               |      2  2.0|
      Bilateral, Abscess, Multifocal       |          2                                                               |      1  2.0|
      Bilateral, Glomerulosclerosis,       |                                                                          |            |
          Diffuse                          |                               1                                          |      2  2.5|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      | 2  2  2     1  1     1  2  1  2     2  1  3  1  1  1        1  2  1  2  2|     33  1.5|
      Bilateral, Pelvis, Bacterium,        |                                                                          |            |
          Multifocal                       |             3                                                            |      1  3.0|
      Glomerulus, Renal Tubule, Amyloid    |                                                                          |            |
          Deposition, Diffuse              |                                                                          |      1  4.0|
      Interstitial Tissue, Renal Tubule,   |                                                                          |            |
           Pigmentation, Multifocal        |                                                                          |      1  1.0|
      Left, Hydronephrosis                 |                                                          2               |      1  2.0|
      Pelvis, Bacterium, Focal             |                                                                          |      1  3.0|
      Pelvis, Bacterium, Multifocal        |                                                                         2|      1  2.0|
      Pelvis, Concretion, Multifocal       |                                                                          |      1  2.0|
      Renal Tubule, Bacterium, Multifocal  |          2                                                               |      1  2.0|
      Renal Tubule, Casts Protein,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Focal    |                                                          3           2   |      3  2.7|
      Renal Tubule, Regeneration, Focal    |    1                                                                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9|            |
                                           | 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |                                                                      1   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
      Abscess, Focal                       |          4                                                               |      1  4.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                        1     3        1                  |      4  1.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2  2     3                 2           2              3        2      |     16  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|             
                                           | 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation, Focal                   |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  M  M  +  +  M  +  M  +  +  +  M  +  M  A  +  M|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                       2                  |             
      Inflammation, Acute, Focal           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  +  A  A  +  +  +|             
      Ulcer, Diffuse                       |                                                                          |             
      Wall, Abscess, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  A  +  +  +  M  +  +  +|             
      Inflammation, Acute, Focal           |          1              1        1     1                             1   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  A  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  A  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  A  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  A  +  +  A  A  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid,|                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                1        2  2  2           1        2              1      |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      2                 1                                 |             
      Bile Duct, Infiltration Cellular,    |                                                                          |             
           Multifocal, Lymphocyte          |                                                       1  1               |             
      Bile Duct, Mineralization, Multifocal|                                                                          |             
      Serosa, Inflammation, Acute, Focal   |                                              4                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +  +        +  +              +              +  +         |             
      Abscess, Multifocal                  |                4           4  4              4              4  4         |             
      Cyst, Single                         |       4                                                                  |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Pigmentation, Diffuse                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|             
                                           | 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
      Inflammation, Acute, Focal           |                                                                3         |             
      Inflammation, Chronic, Diffuse       |                                                    2                     |             
      Inflammation, Chronic, Focal         |                                  1                       3               |             
      Inflammation, Chronic, Multifocal    |       2                                                                  |             
      Duct, Inflammation, Chronic, Focal   |                                                                          |             
      Duct, Inflammation, Chronic,         |                                                                          |             
          Multifocal                       |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                         1        1                    1                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                            2              1                          2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|             
      Abscess, Focal                       |                         2                                                |             
      Acanthosis, Focal                    |                                        2              3                  |             
      Cyst Epithelial Inclusion, Focal     |                                                          1               |             
      Hyperkeratosis, Focal                |                                        2              2                 3|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic, Focal         |                                  2     2              2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Acute, Focal           |          1                                                               |             
      Inflammation, Acute, Multifocal      |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic, Focal |                                                                2     3   |             
      Atrium Left, Thrombosis              |                                                                         3|             
      Epicardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Diffuse                         |                               3                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                                1         |             
      Pericardium, Inflammation, Chronic,  |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Capsule, Inflammation, Chronic,      |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|             
                                           | 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           | 2                                                                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Hypertrophy, Focal                   |                      3                                                   |             
      Bilateral, Hematopoietic Cell        |                                                                          |             
          Proliferation, Diffuse           |                               3                                          |             
      Bilateral, Hematopoietic Cell        |                                                                          |             
          Proliferation, Multifocal        |                            2                       1                     |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Diffuse                         |    2                                                                     |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Diffuse                         |       2  2  2        2     2  2  2  2  2  3  2     2  2  2  2     2  2   |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Multifocal                      | 2  2           2                                2                        |             
      Spindle Cell, Hyperplasia, Diffuse   |                   2     2                                                |             
      Spindle Cell, Hyperplasia, Multifocal|                                                                         2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                               2                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  +  M  M  +  M  +  M  M  M  +  +  +  +  M  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
      Craniopharyngeal Duct, Cyst          |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Multifocal              |                                           3                              |             
      Inflammation, Chronic, Focal         |                                                       2                  |             
      Ultimobranchial Cyst                 |    X  X                 X        X     X        X        X           X  X|             
      Follicle, Cyst                       |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Abscess, Multifocal                  |                4                                   4        4     4      |             
      Cyst, Single                         |       3                                                  3               |             
      Mineralization, Focal                |                                                                          |             
      Bilateral, Abscess, Multifocal       |                            4  4                                          |             
      Bilateral, Cyst, Multiple            |                                  4                                       |             
      Germinal Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           3                              |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|             
                                           | 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Chronic, Diffuse                |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                               +                                          |             
      Inflammation, Acute, Diffuse         |                               4                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                      3                                                   |             
      Abscess, Multifocal                  |                                              4     4                     |             
      Dilatation                           | 3  3                                                                     |             
      Inflammation, Acute, Diffuse         |                         1  2                                             |             
      Endometrium, Edema, Diffuse          |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Diffuse                         |       2     1           2        2  2  3                 2        2  2  2|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Multifocal                      |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia, Diffuse   |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Iliac, Infiltration Cellular,        |                                                                          |             
          Diffuse, Plasma Cell             |                                                    3                     |             
      Mediastinal, Abscess, Multifocal     |                                                                          |             
      Mediastinal, Hyperplasia, Diffuse,   |                                                                          |             
           Lymphoid                        |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Diffuse, Plasma Cell             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                  +     +           +     +           +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |                                        2                 1           2   |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Plasma Cell                      |                                        1           3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                   1      |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |             
      Hyperplasia, Diffuse, Re Cell        |                1                                                         |             
      Hyperplasia, Lymphoid, Multifocal    |                                           1                       2      |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Plasma Cell                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         | 2              2           3  3                    3        3  2  2      |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|             
                                           | 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Diffuse                |                      1                                                   |             
      Capsule, Inflammation, Chronic, Focal|                                                             4            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                                              4                           |             
      Atrophy, Diffuse                     |    3     3  4        3        2                    4  2        4  3     3|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Mediastinum, Abscess, Multifocal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Diffuse                 |          1           1                 1           2        1        1  1|             
      Inflammation, Acute                  |                               4                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +           +  +        +  +  +  +        +  +  +        +  +  +|             
      Acanthosis, Diffuse                  |                                                          1               |             
      Acanthosis, Multifocal               |                                        1                                 |             
      Hyperkeratosis, Diffuse              |                                                          1               |             
      Hyperkeratosis, Focal                |                                        1                                 |             
      Hyperkeratosis, Multifocal           |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                       1  1               |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Hair Follicle, Atrophy, Diffuse      |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fracture Healed               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Thalamus, Mineralization, |                                                                          |             
           Multifocal                      |       1  1  1              1        1  1  1              1     1     1   |             
      Meninges, Cerebrum, Abscess,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Thalamus, Hemorrhage, Multifocal     |                                                                          |             
      Thalamus, Mineralization, Focal      |                                              1        1                  |             
      Thalamus, Mineralization, Multifocal |                         1                                         1      |             
      Ventricle, Abscess, Multifocal       |                      4                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                                                                          |             
      Hemorrhage, Diffuse                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|             
                                           | 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Diffuse, Lymphocyte             |                                                                      3   |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Multifocal, Lymphocyte          | 3  3  2           2  1  2        2  2  2              2  2  1  1         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |          2     2  2  3     1     1     3  1           3  1     1  3  2   |             
      Pleura, Inflammation, Chronic,       |                                                                          |             
          Diffuse                          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       1  1  2  1     3  2  1        1  1  1  1  2  1  2  2  2  2  2  3  1|             
      Glands, Hyperplasia                  | 1  2  3  2  3  2  1  1  3  2     1  2  2  3  2  2  2  2  2     2  2  2  3|             
      Olfactory Epithelium, Atrophy        | 3  3  3  3  3  3  1  3  3  3     2  3  4  3  3  3  3  3  3  2  3  3  3  3|             
      Turbinate, Exudate                   |       2     3           2                 1  2  3     2  1           2   |             
      Turbinate, Hemorrhage, Diffuse       |                      3                                                   |             
      Turbinate, Hemorrhage, Multifocal    |    3                                                                     |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
          Multifocal                       |       1     1           1           1     1        1     1        1  1   |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |                                        2              3              3   |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Focal                           |                                           1        2                    2|             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |       3     3  1     2  2  1                 1           1        2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                         2                                                |             
      Inflammation, Chronic, Focal         |                                                                      1   |             
      Inflammation, Chronic, Multifocal    |             1                                            1               |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic, Diffuse                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic, Multifocal    |                   1              1     2  1              1               |             
      Bilateral, Glomerulosclerosis,       |                                                                          |             
          Diffuse                          |                                                                          |             
      Bilateral, Hematopoietic Cell        |                                                                          |             
          Proliferation, Diffuse           |                               2                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      | 1     2  1  1        3  1  2                          2        1  2  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|             
                                           | 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Cortex, Abscess,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Bilateral, Renal Tubule, Bacterium,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Renal Tubule, Casts       |                                                                          |             
          Protein, Multifocal              |                                                                          |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Pigmentation, Multifocal         |       3                                                                  |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Regeneration, Multifocal         |                                                                          |             
      Capsule, Interstitial Tissue,        |                                                                          |             
          Inflammation, Chronic            |                                                                          |             
      Pelvis, Bacterium, Multifocal        |                                                                          |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Renal Tubule, Regeneration, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  A  +  A  +  +  M  +  +  +  +|             
      Abscess, Focal                       |                            1                                             |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |       1                          1        1                              |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      | 2        2  1  2        2           1                 1        2  2  2   |             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Perforation, Focal                   | 4                                                                        |      1  4.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Chronic                         |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  M  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  A  +  M  +  M  +|  34        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                                  2                                       |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |             3                                         2                  |      2  2.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inflammation, Acute, Focal           |                      1              1                                    |      3  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Ulcer, Diffuse                       |                                                 4                        |      1  4.0|
      Wall, Abscess, Multifocal            |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Inflammation, Acute, Focal           |    1  1  1     1        1  1        1     1           1           1      |     15  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  A  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +|  40        |
      Peyer's Patch, Hyperplasia, Lymphoid,|                                                                          |            |
           Multifocal                      |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                         1              1           1  1                 1|     12  1.3|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                     2                                    |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                            1              2                              |      4  1.5|
      Bile Duct, Infiltration Cellular,    |                                                                          |            |
           Multifocal, Lymphocyte          |             1                    2                                       |      4  1.3|
      Bile Duct, Mineralization, Multifocal|                   2                                                      |      1  2.0|
      Serosa, Inflammation, Acute, Focal   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                    +     +                    +            |  12        |
      Abscess, Multifocal                  |                                        4                    4            |      8  4.0|
      Cyst, Single                         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |             3                                                            |      1  3.0|
      Pigmentation, Diffuse                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess, Multifocal                  |                                                                          |      1  4.0|
      Inflammation, Acute, Diffuse         |                                        3                                 |      1  3.0|
      Inflammation, Acute, Focal           |                                                                          |      1  3.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |    2                    1                                         1      |      5  1.6|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Duct, Inflammation, Chronic, Focal   |       1                                                                  |      1  1.0|
      Duct, Inflammation, Chronic,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  45        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |             1  1                                                         |      5  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       1  1              1           1              1                     |      8  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Abscess, Focal                       |                                                                          |      1  2.0|
      Acanthosis, Focal                    |                                                                          |      2  2.5|
      Cyst Epithelial Inclusion, Focal     |                                                                          |      1  1.0|
      Hyperkeratosis, Focal                |                                                                          |      3  2.3|
      Hyperplasia, Basal Cell              |                4                                                         |      1  4.0|
      Inflammation, Chronic, Focal         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic, Focal |                                                       3                  |      3  2.7|
      Atrium Left, Thrombosis              |                                                                          |      1  3.0|
      Epicardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                        2           1                     |      2  1.5|
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Pericardium, Inflammation, Chronic,  |                                                                          |            |
           Focal                           |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Inflammation, Chronic,      |                                                                          |            |
          Multifocal                       |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                 1                        |      1  1.0|
      Hypertrophy, Focal                   |                                                                          |      1  3.0|
      Bilateral, Hematopoietic Cell        |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  3.0|
      Bilateral, Hematopoietic Cell        |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      2  1.5|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Diffuse                         |    3  2  2     3  2  2  2  2     2  2     2           2        2  2  2  2|     33  2.1|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Multifocal                      |             2                 1              2  1        2  2            |     10  1.8|
      Spindle Cell, Hyperplasia, Diffuse   |                                        2           2                     |      4  2.0|
      Spindle Cell, Hyperplasia, Multifocal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  +  M  M  +  M  +  M  M  +  +  +  +  +  M  +  M  M|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hypertrophy, Focal                   |                                                       1                  |      1  1.0|
      Craniopharyngeal Duct, Cyst          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Multifocal              |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |       X           X     X  X           X                 X     X  X     X|     18     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |                                  X                                       |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess, Multifocal                  |                                        4           4        4            |      7  4.0|
      Cyst, Single                         |          4  3                                                            |      4  3.3|
      Mineralization, Focal                |          2                       2                                       |      2  2.0|
      Bilateral, Abscess, Multifocal       |                                                                          |      2  4.0|
      Bilateral, Cyst, Multiple            |                                                                          |      1  4.0|
      Germinal Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic, Diffuse                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Inflammation, Acute, Diffuse         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Focal                       |                                                                          |      1  3.0|
      Abscess, Multifocal                  |                                                                          |      2  4.0|
      Dilatation                           |          3           3  4                                3        3      |      7  3.1|
      Inflammation, Acute, Diffuse         |       1                                                                  |      3  1.3|
      Endometrium, Edema, Diffuse          |                                        2                                 |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Diffuse                         |    1  2     3  2  1  2           2  2     3        2  1     2  1  1  2  2|     26  1.9|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia, Diffuse   |       1              1                          2                        |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Iliac, Infiltration Cellular,        |                                                                          |            |
          Diffuse, Plasma Cell             |                                                                          |      1  3.0|
      Mediastinal, Abscess, Multifocal     |                                                    4                     |      1  4.0|
      Mediastinal, Hyperplasia, Diffuse,   |                                                                          |            |
           Lymphoid                        |                         3                                                |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Infiltration Cellular,        |                                                                          |            |
          Diffuse, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +        +  +  +              +     +     +                    +  +|  15        |
      Hyperplasia, Focal, Lymphoid         |                                           1                              |      1  1.0|
      Hyperplasia, Lymphoid, Multifocal    |                3     2              2                                1  2|      8  1.9|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Plasma Cell                      |                2     2              3           3                       1|      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Hyperplasia, Diffuse, Lymphoid       |                                     3                                    |      1  3.0|
      Hyperplasia, Diffuse, Re Cell        |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid, Multifocal    |       1                                                                  |      3  1.3|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Plasma Cell                      |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |                1  1  2     1           3        3  2  1     2     2      |     18  2.1|
      Hyperplasia, Diffuse, Lymphoid       |       2                          2                                   3   |      3  2.3|
      Hyperplasia, Lymphoid, Multifocal    |                                     1                                    |      2  1.0|
      Pigmentation, Diffuse                |                               1              1                           |      3  1.0|
      Capsule, Inflammation, Chronic, Focal|                                        4                                 |      2  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +|  42        |
      Abscess, Focal                       |                                                                          |      1  4.0|
      Atrophy, Diffuse                     |       2                                         3           3            |     13  3.0|
      Hyperplasia, Focal, Lymphoid         |                         2                                                |      1  2.0|
      Mediastinum, Abscess, Multifocal     |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Diffuse                 |                                                 1                        |      8  1.1|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +        +  +  +  +|  34        |
      Acanthosis, Diffuse                  |                                                                      1   |      2  1.0|
      Acanthosis, Multifocal               |                                     1                          1         |      3  1.0|
      Hyperkeratosis, Diffuse              |                                                                          |      1  1.0|
      Hyperkeratosis, Focal                |                                                                          |      1  1.0|
      Hyperkeratosis, Multifocal           |                                     1                          1         |      2  1.0|
      Inflammation, Chronic, Diffuse       |    1                                2                                   1|      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic, Focal         |                                                                      1   |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                                1         |      1  1.0|
      Hair Follicle, Atrophy, Diffuse      |                                        1           1                     |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fracture Healed               |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Thalamus, Mineralization, |                                                                          |            |
           Multifocal                      |    1  1     1     1  1  2                             2                  |     17  1.1|
      Meninges, Cerebrum, Abscess,         |                                                                          |            |
          Multifocal                       |                                                          4               |      1  4.0|
      Thalamus, Hemorrhage, Multifocal     |                               3                                          |      1  3.0|
      Thalamus, Mineralization, Focal      |                                                    1                     |      3  1.0|
      Thalamus, Mineralization, Multifocal |          1     1           1                    1                        |      6  1.0|
      Ventricle, Abscess, Multifocal       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Multifocal                  |                                        2           3                     |      2  2.5|
      Hemorrhage, Diffuse                  |                               4                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                       3                  |      1  3.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Diffuse, Lymphocyte             |                                                                          |      1  3.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Multifocal, Lymphocyte          |    1  3     2  2  2  2  3        2  2     2        1  1        1  1  1   |     28  1.8|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          |    2  2  1              3  3           1  2           1  3              1|     23  1.9|
      Pleura, Inflammation, Chronic,       |                                                                          |            |
          Diffuse                          |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |       1  2  1  1              1     2  1  1  3  2  1  2  2        1     1|     35  1.5|
      Glands, Hyperplasia                  |    2  2  1  3  2  1  3  2  3  1  1  2  2  2  2     1  2  2     3  3  3  3|     45  2.1|
      Olfactory Epithelium, Atrophy        |    3  3  3  3  4  2  3  3  4  1  3  4  3  3  2     3  4  4     3  3  2  3|     46  2.9|
      Turbinate, Exudate                   |          2  1  2           2        2  1  1  2     2  3  2     1        1|     22  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Turbinate, Hemorrhage, Diffuse       |                               3                                          |      2  3.0|
      Turbinate, Hemorrhage, Multifocal    |                                                                          |      1  3.0|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Multifocal                       |    1        1  1     2  1  1        1     1        1  1        1     1  1|     22  1.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         |                2     3     3        2     2           3                 2|     10  2.5|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Focal                           |                                        1                                 |      4  1.5|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |          3  2                    2           2  1  2     3        1      |     17  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Diffuse       |                2                                                  1      |      3  1.7|
      Inflammation, Chronic, Focal         |       1     1                          1                                1|      5  1.0|
      Inflammation, Chronic, Multifocal    |                   1        1     1  1                 1                  |      7  1.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Chronic, Diffuse                |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |          1                                                              1|      2  1.0|
      Inflammation, Chronic, Multifocal    |                         1                 1        1              1  1   |     10  1.1|
      Bilateral, Glomerulosclerosis,       |                                                                          |            |
          Diffuse                          |                                                 1                        |      1  1.0|
      Bilateral, Hematopoietic Cell        |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  2.0|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |    1  2     2  2           3        2  1                 2  2  1         |     21  1.7|
      Bilateral, Cortex, Abscess,          |                                                                          |            |
          Multifocal                       |                                                 3                        |      1  3.0|
      Bilateral, Renal Tubule, Bacterium,  |                                                                          |            |
           Multifocal                      |                                                 3                        |      1  3.0|
      Bilateral, Renal Tubule, Casts       |                                                                          |            |
          Protein, Multifocal              |                                                 1                        |      1  1.0|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Pigmentation, Multifocal         |                                                 2                        |      2  2.5|
      Bilateral, Renal Tubule,             |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3|            |
                                           | 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Regeneration, Multifocal         |                                                                2         |      1  2.0|
      Capsule, Interstitial Tissue,        |                                                                          |            |
          Inflammation, Chronic            |                                                 3                        |      1  3.0|
      Pelvis, Bacterium, Multifocal        |                                                             2            |      1  2.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       |                                                                1         |      1  1.0|
      Renal Tubule, Regeneration, Focal    |                                                                      1   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Abscess, Focal                       |                                                                          |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                      2           1        1                              |      6  1.2|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2     2  2     2     2  2                          2  2     2  2  2  1|     22  1.8|
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|             
                                           | 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                    2                     |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                       1        1         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia, Focal, |                                                                          |             
           Lymphoid                        |                                        2                                 |             
      Lymphoid Nodule, Hyperplasia,        |                                                                          |             
          Lymphoid, Multifocal             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Acute, Focal           |          1  1     1  1           1  1     1     1  1                    1|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Diffuse, |                                                                          |             
           Lymphoid                        |                      3                                                   |             
      Peyer's Patch, Hyperplasia, Focal,   |                                                                          |             
           Lymphoid                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Multifocal              |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                            1                                             |             
      Hypertrophy, Focal                   |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |             2                                                        1   |             
      Inflammation, Acute, Multifocal      |                                                    1                     |             
      Bile Duct, Infiltration Cellular,    |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
      Hepatocyte, Focal Cellular Change    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +                                          |             
      Inflammation, Acute, Multifocal      |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|             
                                           | 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fat, Necrosis, Multifocal            |                               4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Atrophy, Focal                       |                               4                          2               |             
      Inflammation, Chronic, Diffuse       |                               3                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic, Multifocal    |                   1                                                      |             
      Necrosis, Focal                      |                               4                                          |             
      Duct, Cyst, Single                   |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
      Duct, Inflammation, Chronic, Focal   |                                                                          |             
      Duct, Inflammation, Chronic,         |                                                                          |             
          Multifocal                       |                                                       1                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |       1              1     1           1           1                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          2  3     2     1           1     1           1  1     1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                                        2                                 |             
      Abscess, Multifocal                  |                                                                          |             
      Acanthosis, Focal                    |                                        2        2  2              3      |             
      Cyst Epithelial Inclusion, Focal     |                                                                      1   |             
      Hyperkeratosis, Focal                |                                                                          |             
      Inflammation, Acute, Focal           |                2                                                         |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium Left, Bacterium, Focal        |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                                          |             
      Cyst, Single                         |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|             
                                           | 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
           Multifocal                      |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Diffuse                         |                                                             3            |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Diffuse                         |       2  2  2     2  3  2  2     2  2  2  3     1  2  2  2     3  2  2  3|             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Multifocal                      | 2                             2              1              2            |             
      Spindle Cell, Hyperplasia, Diffuse   |    1           2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  M  +  +  M  +  +  M  +  M  M  M  M  M  +  M  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                X           X                                             |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       | 4                                                                        |             
      Cyst, Single                         |          2        3                                      2        1      |             
      Bilateral, Abscess, Multifocal       |                            4                                             |             
      Bilateral, Cyst, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2     2  2        2              2        4     3                        |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Diffuse                         |          1  2     1  2  2        2  2  2  2        1  1     2  2     2  2|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Multifocal                      |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse, Lymphoid       |                                                       4                  |             
      Hyperplasia, Diffuse, Re Cell        |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |       2                                2  1     1  1           1  1      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|             
                                           | 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Diffuse                         |    2                       2  2                             1            |             
      Hyperplasia, Diffuse, Lymphoid       |             2                    2     1  3        2              1  1   |             
      Hyperplasia, Lymphoid, Multifocal    |       1                                               1                  |             
      Hyperplasia, Multifocal, Re Cell     |                                                                          |             
      Pigmentation, Diffuse                |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Atrophy, Diffuse                     |    2                       4  4              2                           |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Hyperplasia, Focal, Re Cell          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  I  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +     +  +                 +              +  +     +  +  +  +|             
      Acanthosis, Diffuse                  |                                                                          |             
      Acanthosis, Focal                    |                                                       1                  |             
      Acanthosis, Multifocal               |       1     1     2                    1                 1     1  1     1|             
      Hyperkeratosis, Diffuse              |                                                                          |             
      Inflammation, Acute, Multifocal      |                                        2                                 |             
      Inflammation, Chronic, Diffuse       |       1                                                                  |             
      Inflammation, Chronic, Multifocal    |                   1                                                      |             
      Ulcer, Focal                         |                                                                          |             
      Hair Follicle, Acanthosis, Diffuse   |                      1                                                   |             
      Hair Follicle, Atrophy, Diffuse      |       1     1                          2              2           1      |             
      Hair Follicle, Atrophy, Multifocal   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                        +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Thalamus, Mineralization, |                                                                          |             
           Multifocal                      |                         1     1           1           1        1     1   |             
      Thalamus, Mineralization, Focal      |                                              1                           |             
      Thalamus, Mineralization, Multifocal |       1           1        1                                1            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolus, Inflammation, Acute, Focal |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Diffuse, Lymphocyte             |                                                                      3   |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|             
                                           | 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Multifocal, Lymphocyte          |       1  2  1     2  2  1  1     3  3  2  1     1  3  2  2     1  1     1|             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Multifocal, Lymphocyte |                1                                                         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Diffuse, Lymphocyte             |                                                                      3   |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |                         1        1              1                        |             
      Pleura, Foreign Body, Focal          |                                                                          |             
      Pleura, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    1     2     2  1  1  2     2  1        2     2  1     1  1            |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Glands, Hyperplasia                  | 3  3  3  2  3  3  4  4  3  3  3  2  4  3  4  3  3  4  2  3  3  2  4  4  3|             
      Olfactory Epithelium, Atrophy        | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  4  3  3  3  3  4  3  3  3  3|             
      Turbinate, Exudate                   |    2           2  2     2           2     1     3  1     2               |             
      Turbinate, Fungus, Focal             |                               4                                          |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
          Diffuse                          |                                                    2                     |             
      Turbinate, Inflammation, Acute, Focal|                               4                                          |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
          Multifocal                       |    2  2  2  1  1  2  1  2        1  2  1  1     1     1  1        1  1  1|             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |                3                                                         |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Focal                           |                                                       1                  |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                         1  2     2  2     2     3  3                 1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                1                                                         |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic, Multifocal    |             1                    1     1           1           1     1   |             
      Peritracheal Tissue, Foreign Body,   |                                                                          |             
           Focal                           |                                                                          |             
      Peritracheal Tissue, Hemorrhage,     |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|             
                                           | 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                1         |             
      Inflammation, Chronic, Multifocal    |          2                             1  1              1        1      |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |       1     2     2  2  1  1     2  1           1  2                 2   |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Mineralization, Multifocal       |                                              1                           |             
      Pelvis, Bacterium, Multifocal        |                            1                                             |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                              +                           |             
      Dilatation                           |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |       1           1     1                                                |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          1  3        1           2  2     1        2              1  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Perforation, Focal                   |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +|  42        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      2  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                           1                              |      1  1.0|
      Inflammation, Acute, Diffuse         |                                                          2               |      1  2.0|
      Inflammation, Acute, Focal           |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoid Nodule, Hyperplasia, Focal, |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
      Lymphoid Nodule, Hyperplasia,        |                                                                          |            |
          Lymphoid, Multifocal             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Acute, Focal           | 1  1     1  1           1        1     1  1        1     1     1        1|     22  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Peyer's Patch, Hyperplasia, Diffuse, |                                                                          |            |
           Lymphoid                        |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia, Focal,   |                                                                          |            |
           Lymphoid                        |                                  3        2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Multifocal              |       2                                                                  |      1  2.0|
      Fatty Change, Diffuse                |                3                                                         |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Hypertrophy, Focal                   |          1                                                               |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                       1                  |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                         2        1                                       |      4  1.5|
      Inflammation, Acute, Multifocal      |                                        2                                 |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Bile Duct, Infiltration Cellular,    |                                                                          |            |
           Multifocal, Lymphocyte          |       1     1           1              1  1                              |      5  1.0|
      Hepatocyte, Focal Cellular Change    |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Inflammation, Acute, Multifocal      |                                                                          |      1  4.0|
      Fat, Necrosis, Multifocal            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Atrophy, Diffuse                     |                                                                4         |      1  4.0|
      Atrophy, Focal                       |                      3                                                   |      3  3.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                1  1                                                      |      2  1.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  4.0|
      Duct, Cyst, Single                   |                                                                3  2      |      2  2.5|
      Duct, Dilatation                     |                      3                                                   |      1  3.0|
      Duct, Inflammation, Chronic, Focal   |       2                                1                                 |      2  1.5|
      Duct, Inflammation, Chronic,         |                                                                          |            |
          Multifocal                       |                                                                3  2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |       1                             1     1        2                     |      9  1.1|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 3           2     1                    2     1        2        3        3|     17  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess, Focal                       |                                                                          |      1  2.0|
      Abscess, Multifocal                  |                                                    2                     |      1  2.0|
      Acanthosis, Focal                    |                                     1              2     1               |      7  1.9|
      Cyst Epithelial Inclusion, Focal     |                                                                          |      1  1.0|
      Hyperkeratosis, Focal                |                                     2                                    |      1  2.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Focal           |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium Left, Bacterium, Focal        |                   4                                                      |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrium Left, Thrombosis              |                   X                                                      |      1     |
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           | 2                 2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Multiple                       |                                                 1                        |      1  1.0|
      Cyst, Single                         | 2                                                                        |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                               2                                          |      1  2.0|
      Hypertrophy, Focal                   |    2                                                                     |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Diffuse                         | 3  2  1  2  2           2  2     2  2  2  2  3  2  2  2  2     2  3  2  2|     39  2.1|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Multifocal                      |                2  2  2                                                   |      7  1.9|
      Spindle Cell, Hyperplasia, Diffuse   |                               2                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  +  M  +  M  M  +  +  M  +  M  +  +  M  M  +  M  +  M  M  M  M|  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Hypertrophy, Focal                   |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |       X                                         X                        |      4     |
      Follicle, Cyst                       |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|  48        |
      Cyst, Multiple                       |                                                                          |      1  4.0|
      Cyst, Single                         |    1  4     2              2              2                          1   |     10  2.0|
      Bilateral, Abscess, Multifocal       |                                                                          |      1  4.0|
      Bilateral, Cyst, Multiple            | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 2           2                    2  2  4                       2     2   |     14  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Diffuse                         | 1  1  2              1  2        1        2  2  2     2           2     2|     27  1.7|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia, Diffuse   |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hyperplasia, Diffuse, Lymphoid       |                                        2                                 |      2  3.0|
      Hyperplasia, Diffuse, Re Cell        |                         3                                                |      1  3.0|
      Hyperplasia, Lymphoid, Multifocal    | 2           2                             2  2     1     1           1   |     14  1.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |                   1     2     3                                          |      7  1.9|
      Hyperplasia, Diffuse, Lymphoid       |       2     2                    2     2  2  2  1                    2  2|     16  1.8|
      Hyperplasia, Lymphoid, Multifocal    | 1                                                                        |      3  1.0|
      Hyperplasia, Multifocal, Re Cell     |                         1                                                |      1  1.0|
      Pigmentation, Diffuse                |                2           2                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Atrophy, Diffuse                     |                3  4                                                      |      6  3.2|
      Hyperplasia, Focal, Lymphoid         |                                                    2                 2   |      2  2.0|
      Hyperplasia, Focal, Re Cell          |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  42        |
      Hyperplasia, Diffuse                 |                               1        1  1                              |      3  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                            +  +                                   +      |  14        |
      Acanthosis, Diffuse                  |                               1                                          |      1  1.0|
      Acanthosis, Focal                    |                                                                   1      |      2  1.0|
      Acanthosis, Multifocal               |                                                                          |      8  1.1|
      Hyperkeratosis, Diffuse              |                               1                                          |      1  1.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Inflammation, Chronic, Diffuse       |                               3                                          |      2  2.0|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  1.0|
      Ulcer, Focal                         |                               3                                          |      1  3.0|
      Hair Follicle, Acanthosis, Diffuse   |                                                                          |      1  1.0|
      Hair Follicle, Atrophy, Diffuse      |                                                                   2      |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hair Follicle, Atrophy, Multifocal   |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Thalamus, Mineralization, |                                                                          |            |
           Multifocal                      |       1  1  1  1                          1  1                 1  1  1   |     15  1.0|
      Thalamus, Mineralization, Focal      |                      1        1                 1                        |      4  1.0|
      Thalamus, Mineralization, Multifocal |    1                                               1                     |      6  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolus, Inflammation, Acute, Focal |                                                       1                  |      1  1.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Diffuse, Lymphocyte             |                                                                          |      1  3.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Multifocal, Lymphocyte          | 2  1  2     2     2  1  1        1     2  2  2  1     2  3        1  1  3|     35  1.7|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Multifocal, Lymphocyte |                               3                                          |      2  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Diffuse, Lymphocyte             |                                                                          |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          | 1                                   2  1                 3           1   |      8  1.4|
      Pleura, Foreign Body, Focal          |                                                             2            |      1  2.0|
      Pleura, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 1  1  2  1     1  1  2  2     1  1  1     2  1  1  1     2  1  2  1     1|     33  1.4|
      Hyperplasia, Focal, Lymphoid         |                                                                3         |      1  3.0|
      Glands, Hyperplasia                  | 4  3  4  3  2  2  2  4  4  3  3  4  4  4  4  4  3  3  3  4     4  4  3  4|     49  3.3|
      Olfactory Epithelium, Atrophy        | 3  3  3  3  3  3  4  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3|     49  3.1|
      Turbinate, Exudate                   |       3  2              2  4              2  2           3     2         |     17  2.2|
      Turbinate, Fungus, Focal             |                                                                          |      1  4.0|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Diffuse                          |                                                                1         |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3|            |
                                           | 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Turbinate, Inflammation, Acute, Focal|                                                                          |      1  4.0|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Multifocal                       | 1  1  1  1     3     1  1  1  1  1  1  1  1  1  1  1  1  1        1  1  1|     39  1.2|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         |                            3                             3               |      3  3.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Focal                           |                                                                         2|      2  1.5|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |                         1     1        1  2  2        2           1      |     16  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Inflammation, Chronic, Diffuse       |                                                          1               |      1  1.0|
      Inflammation, Chronic, Focal         |                                  1                                       |      1  1.0|
      Inflammation, Chronic, Multifocal    |                         1              1  1                    1         |     10  1.0|
      Peritracheal Tissue, Foreign Body,   |                                                                          |            |
           Focal                           |                                                             2            |      1  2.0|
      Peritracheal Tissue, Hemorrhage,     |                                                                          |            |
           Focal                           |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Multiple                       |                                                                          |      1  4.0|
      Inflammation, Chronic, Focal         |                                     1              1              1      |      4  1.0|
      Inflammation, Chronic, Multifocal    |          1                                               1               |      7  1.1|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      | 2  2        3              1     1        2  1        2              2  1|     21  1.6|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Mineralization, Multifocal       |                                                                          |      1  1.0|
      Pelvis, Bacterium, Multifocal        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |             1                                         2                  |      5  1.2|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      | 1  1                    1        1     2  2  2  1                    1  2|     19  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  M  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |    3                                               2                    2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                     2                                    |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |    1                 1                    1           1  1  1        1   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                               X                                          |             
      Cyst, Multiple                       |                                                                          |             
      Infarct, Focal                       |                                                                          |             
      Necrosis, Coagulative, Diffuse       |                                                                          |             
      Bile Duct, Infiltration Cellular,    |                                                                          |             
           Multifocal, Lymphocyte          |                                                    3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                                                                          |             
      Atrophy, Focal                       |                   2                                                      |             
      Inflammation, Chronic, Focal         |                                              1                           |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Necrosis, Focal                      | 1                                                                        |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                2     1  2                       2  1                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                     1  3  1  2        2  2        1  2  1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Focal                       |                                                          2  2        1   |             
      Abscess, Multifocal                  |                                                    1                     |             
      Acanthosis, Focal                    |                                                          3           3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acanthosis, Multifocal               |                                                    1                     |             
      Cyst Epithelial Inclusion, Focal     |                   2                                                      |             
      Inflammation, Chronic, Focal         |                                                          2           2   |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Serosa, Inflammation, Acute, Diffuse |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic, Multifocal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Aorta, Adventitia,|                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Mesenteric Artery, Aorta, Media,     |                                                                          |             
           Hypertrophy, Multifocal         |                                                                          |             
      Mesenteric Artery, Renal Artery,     |                                                                          |             
           Adventitia, Inflammation,       |                                                                          |             
          Chronic, Multifocal              |                                                                          |             
      Mesenteric Artery, Renal Artery,     |                                                                          |             
           Media, Hypertrophy, Diffuse     |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Diffuse                          |                                                                          |             
      Endocardium, Inflammation, Chronic,  |                                                                          |             
           Focal                           |                               1                                          |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Diffuse                         |                                                                          |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Focal                           | 1                                                                        |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Multifocal                      |    1  2  2  1  1     2  2     1        1  1     2        2  1     1  1   |             
      Spindle Cell, Hyperplasia, Focal     |                   1                          1                 1         |             
      Spindle Cell, Hyperplasia, Multifocal|                            1        2              1  2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                              1                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  +  M  M  M  +  M  +  M  +  +  M  +  +  +  +  +  M  M  M|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                               1                                          |             
      Ultimobranchial Cyst                 |                                        X           X     X              X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Multifocal          |                                                                          |             
      Inflammation, Chronic, Focal         |                                           1                              |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Diffuse                         |                                              3                           |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Multifocal                      |                                                                          |             
      Serosa, Inflammation, Acute, Diffuse |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                    +  +     +            |             
      Abscess, Focal                       |                                                       4                  |             
      Abscess, Multifocal                  |                                                             4            |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Bilateral, Dilatation                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Abscess, Multifocal                  |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                        2              1                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      1                                                   |             
      Inflammation, Acute, Diffuse         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Abscess, Multifocal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Vacuolization Cytoplasmic,       |                                                                          |             
          Diffuse                          |                                              3                           |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Diffuse                         |                                           3                              |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Focal                           |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid,     |                                                                          |             
           Multifocal                      |          2                    1                                          |             
      Inguinal, Hyperplasia, Diffuse,      |                                                                          |             
          Lymphoid                         |                                  3                                       |             
      Inguinal, Pigmentation, Diffuse      |                                                                          |             
      Renal, Hyperplasia, Lymphoid,        |                                                                          |             
          Multifocal                       |                               1                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |                                  1                          2            |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Focal                           |                   1                                                      |             
      Hyperplasia, Diffuse, Lymphoid       |    1                 3           2                    1                  |             
      Hyperplasia, Diffuse, Re Cell        | 3                                                                        |             
      Hyperplasia, Focal, Lymphoid         |                                           1                          1   |             
      Hyperplasia, Lymphoid, Multifocal    |                   1           1     1                    1        1      |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         | 3        3                 3           3                    2            |             
      Hyperplasia, Diffuse, Lymphoid       |                                  1           2  1                        |             
      Hyperplasia, Focal, Lymphoid         |                                                          1               |             
      Hyperplasia, Lymphoid, Multifocal    |                   3  1        2     1                 1           1     1|             
      Pigmentation, Diffuse                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |       2                                                        3         |             
      Cyst, Single                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Mediastinum, Abscess, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             
      Inflammation, Chronic, Multifocal    |                                              2                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +  +  +  +  +  +                    +  +  +      |             
      Acanthosis, Focal                    |    1                 3        3        1                                 |             
      Acanthosis, Multifocal               |                                     2                             1      |             
      Cyst Epithelial Inclusion, Single    |       2                                                                  |             
      Hyperkeratosis, Focal                |    1                 2        2                                          |             
      Hyperkeratosis, Multifocal           |                                                                   1      |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic, Diffuse       |                      2                                                   |             
      Inflammation, Chronic, Focal         |                            4                                             |             
      Inflammation, Chronic, Multifocal    |    1                                                                     |             
      Ulcer, Focal                         |                            4  3        4                                 |             
      Artery, Subcutaneous Tissue,         |                                                                          |             
          Adventitia, Inflammation,        |                                                                          |             
          Chronic, Focal                   |                                                                          |             
      Artery, Subcutaneous Tissue,         |                                                                          |             
          Adventitia, Inflammation,        |                                                                          |             
          Chronic, Multifocal              |       2                                                                  |             
      Hair Follicle, Atrophy, Diffuse      |       3                             3                                    |             
      Hair Follicle, Inflammation, Chronic,|                                                                          |             
           Multifocal                      |                                                                          |             
      Prepuce, Cyst Epithelial Inclusion,  |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Head, Granuloma,|                                                                          |             
           Focal                           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Thalamus, Mineralization, |                                                                          |             
           Multifocal                      | 1  1  1  2     1  1              1  1  1  1     1     1  1  1        1   |             
      Lateral Ventricle, Meninges, Abscess,|                                                                          |             
           Multifocal                      |             4                                                            |             
      Thalamus, Mineralization, Focal      |                                                                          |             
      Thalamus, Mineralization, Multifocal |                                                    1                     |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                   +           +                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Thrombosis, Diffuse                  |                                                                4         |             
      Alveolar Epithelium, Hyperplasia     |                                           2                             2|             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Multifocal, Lymphocyte          | 1  1        1  1              1  2  2  1  1  1  1  2  1  2        2  1  3|             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Multifocal, Lymphocyte |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |                1                             1     1                     |             
      Pleura, Inflammation, Acute, Diffuse |                                                                          |             
      Pleura, Inflammation, Acute,         |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    1     2  1  2  1        1  1        1     1  1  2  2     2     1  1   |             
      Glands, Hyperplasia                  | 1                                                                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic, Focal                  |                                                                          |             
      Olfactory Epithelium, Atrophy        | 1  2     2  2  2     2                             2                     |             
      Turbinate, Exudate                   |    1     2     2     2                             1        2            |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |                2                                                         |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Focal                           |          2                                                  1            |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |    2        1        3                             2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |    1                 1                 1           1                     |             
      Inflammation, Chronic, Focal         |                                  1                                       |             
      Inflammation, Chronic, Multifocal    |       1                                   1     1        1           1  1|             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic, Multifocal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium, Multifocal                |                                                                          |             
      Casts Protein, Diffuse               |                                                                          |             
      Cyst, Single                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydronephrosis                       |                                  2                                       |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic, Focal         |                                                          2               |             
      Inflammation, Chronic, Multifocal    |                                  3              1  1                     |             
      Bilateral, Inflammation, Acute, Focal|                                                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Focal                           |                                                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |    1  1  1  2  2  2  2     1           2  1           2     2     2  1  1|             
      Bilateral, Artery, Inflammation,     |                                                                          |             
           Chronic, Multifocal             |                                                                          |             
      Bilateral, Renal Tubule, Casts       |                                                                          |             
          Protein, Multifocal              |                                                                          |             
      Bilateral, Renal Tubule, Concretion, |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Degeneration, Multifocal         |                                                                          |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Regeneration, Multifocal         |                                                 1                        |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Vacuolization Cytoplasmic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Interstitial Tissue, Inflammation,   |                                                                          |             
           Chronic, Diffuse                |                                                                          |             
      Renal Tubule, Casts Protein, Diffuse |                                                                          |             
      Renal Tubule, Concretion, Multifocal |                                                                          |             
      Renal Tubule, Degeneration, Focal    |                         1                                                |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |                                           1                              |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                           1                              |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                  +                                       |             
      Dilatation                           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Mucosa, Inflammation, Acute, Diffuse |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                       1                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                         2                 2        1                 1   |             
      Inflammation, Acute, Focal           |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Diffuse                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|             
                                           | 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium,             |                                                                          |             
          Vacuolization Cytoplasmic,       |                                                                          |             
          Diffuse                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  M  +  +  M  +  +  +  +  A  +  +  +  +  +  +  M  +  M  M  +  +  +  +|  38        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                            2                                             |      4  2.3|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                           1                              |      1  1.0|
      Inflammation, Acute, Diffuse         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute, Focal           | 1     1  1  1     1  1  1  1        1                          1  1     1|     19  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Cyst, Multiple                       |                                           X                              |      1     |
      Infarct, Focal                       |                                     4              4                     |      2  4.0|
      Necrosis, Coagulative, Diffuse       |                                                       4                  |      1  4.0|
      Bile Duct, Infiltration Cellular,    |                                                                          |            |
           Multifocal, Lymphocyte          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   1        |
      Inflammation, Acute, Diffuse         |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess, Focal                       |                                              4                           |      1  4.0|
      Atrophy, Focal                       |                                        1                                 |      2  1.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                    1                 1   |      2  1.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Multifocal|                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      5  1.6|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2           1  2        1           2  2        1           2         |     17  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess, Focal                       |                   2                                                      |      4  1.8|
      Abscess, Multifocal                  |                                                                          |      1  1.0|
      Acanthosis, Focal                    |                                                                          |      2  3.0|
      Acanthosis, Multifocal               | 3                                                                        |      2  2.0|
      Cyst Epithelial Inclusion, Focal     |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      2  2.0|
      Inflammation, Chronic, Multifocal    | 2                                                                        |      1  2.0|
      Serosa, Inflammation, Acute, Diffuse |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Artery, Adventitia, Inflammation,    |                                                                          |            |
           Chronic, Multifocal             |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Mesenteric Artery, Aorta, Adventitia,|                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Multifocal                       |                                                          3               |      1  3.0|
      Mesenteric Artery, Aorta, Media,     |                                                                          |            |
           Hypertrophy, Multifocal         |                                                          3               |      1  3.0|
      Mesenteric Artery, Renal Artery,     |                                                                          |            |
           Adventitia, Inflammation,       |                                                                          |            |
          Chronic, Multifocal              |                   3                                                      |      1  3.0|
      Mesenteric Artery, Renal Artery,     |                                                                          |            |
           Media, Hypertrophy, Diffuse     |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Diffuse                          |                   3                                      3               |      2  3.0|
      Endocardium, Inflammation, Chronic,  |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Diffuse                         |                                              3              1            |      2  2.0|
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy, Focal                   |                                     2                                    |      1  2.0|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Multifocal                      |    1              1  1  2           1     2        1  1     1        1   |     25  1.3|
      Spindle Cell, Hyperplasia, Focal     |       1  1  1                    1           1                          2|      9  1.1|
      Spindle Cell, Hyperplasia, Multifocal| 2              1           1  1        1        2              1         |     11  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M  +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  M  M  +  +  M  M|  27        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  M|  40        |
      Hypertrophy, Focal                   |                                                                   1      |      1  1.0|
      Craniopharyngeal Duct, Cyst          |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |    1                                                                     |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                         X                                                |      5     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular, Multifocal          |                      2                                                   |      1  2.0|
      Inflammation, Chronic, Focal         |                                           2        2                 1   |      4  1.5|
      Inflammation, Chronic, Multifocal    |                                                                1         |      1  1.0|
      Vacuolization Cytoplasmic, Diffuse   |       2                                                                  |      1  2.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Multifocal                      |                                        1                                 |      1  1.0|
      Serosa, Inflammation, Acute, Diffuse |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                       +                  |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Focal                  |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +        +     +                 +  +        +     +        M      |  10        |
      Abscess, Focal                       |                      4                 4                 4               |      4  4.0|
      Abscess, Multifocal                  |                                                                          |      1  4.0|
      Dilatation                           |                                                    2                     |      1  2.0|
      Inflammation, Chronic, Diffuse       |       2                                   3        3                     |      3  2.7|
      Inflammation, Chronic, Multifocal    |                2                                                         |      1  2.0|
      Bilateral, Dilatation                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess, Multifocal                  |                                              4                           |      1  4.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                           1                              |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2                                                                     |      2  1.5|
      Inflammation, Acute, Diffuse         |                                              4  3                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                              +                           |   1        |
      Abscess, Multifocal                  |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Vacuolization Cytoplasmic,       |                                                                          |            |
          Diffuse                          |                                        2                                 |      2  2.5|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia, Diffuse   |                               2              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hyperplasia, Lymphoid,     |                                                                          |            |
           Multifocal                      |                                                                          |      2  1.5|
      Inguinal, Hyperplasia, Diffuse,      |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
      Inguinal, Pigmentation, Diffuse      |                                     2                                    |      1  2.0|
      Renal, Hyperplasia, Lymphoid,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Diffuse                         |                                     1                                    |      3  1.3|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Hyperplasia, Diffuse, Lymphoid       |          2  1        3  3           4        3           2           3   |     12  2.3|
      Hyperplasia, Diffuse, Re Cell        |                                                 2                        |      2  2.5|
      Hyperplasia, Focal, Lymphoid         |       1                                                                  |      3  1.0|
      Hyperplasia, Lymphoid, Multifocal    |                2  3                    3                       1  2     1|     11  1.5|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Plasma Cell                      |                                                          2               |      1  2.0|
      Inflammation, Acute, Diffuse         |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         | 2                                            2        3  3               |      9  2.7|
      Hyperplasia, Diffuse, Lymphoid       |                         3                                                |      4  1.8|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid, Multifocal    |       1              1                                            1  2  2|     12  1.4|
      Pigmentation, Diffuse                |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Atrophy, Diffuse                     |                                                 3     3  3  4            |      6  3.0|
      Cyst, Single                         |                                                 2                        |      1  2.0|
      Hyperplasia, Focal, Lymphoid         |                                     4                                    |      1  4.0|
      Mediastinum, Abscess, Focal          |                                              4                           |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  +  M  M  M  M  M  M  M  M|   5        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +        +           +     +  +        +  +  +  +        +  +   |  26        |
      Acanthosis, Focal                    |                                                                          |      4  2.0|
      Acanthosis, Multifocal               |                                                 2                        |      3  1.7|
      Cyst Epithelial Inclusion, Single    |                                                                          |      1  2.0|
      Hyperkeratosis, Focal                |                                                                          |      3  1.7|
      Hyperkeratosis, Multifocal           |                                                 2                        |      2  1.5|
      Inflammation, Acute, Multifocal      |                                                          3               |      1  3.0|
      Inflammation, Chronic, Diffuse       |                               3        2                                 |      3  2.3|
      Inflammation, Chronic, Focal         |                                                       4                  |      2  4.0|
      Inflammation, Chronic, Multifocal    |                                                 1                        |      2  1.0|
      Ulcer, Focal                         |                                                 2     4                  |      5  3.4|
      Artery, Subcutaneous Tissue,         |                                                                          |            |
          Adventitia, Inflammation,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Chronic, Focal                   |                                                                      3   |      1  3.0|
      Artery, Subcutaneous Tissue,         |                                                                          |            |
          Adventitia, Inflammation,        |                                                                          |            |
          Chronic, Multifocal              |                                                                          |      1  2.0|
      Hair Follicle, Atrophy, Diffuse      |                                        3                                 |      3  3.0|
      Hair Follicle, Inflammation, Chronic,|                                                                          |            |
           Multifocal                      |          1                                                               |      1  1.0|
      Prepuce, Cyst Epithelial Inclusion,  |                                                                          |            |
           Focal                           |                                                          3               |      1  3.0|
      Subcutaneous Tissue, Head, Granuloma,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Thalamus, Mineralization, |                                                                          |            |
           Multifocal                      |                      1  1                 1        1     1  1        1  1|     23  1.0|
      Lateral Ventricle, Meninges, Abscess,|                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Thalamus, Mineralization, Focal      |                            1        1                                    |      2  1.0|
      Thalamus, Mineralization, Multifocal |    1     1        1                                            1         |      5  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |    +     +  +  +  +  +                                         +     +   |  10        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                         2                                                |      1  2.0|
      Thrombosis, Diffuse                  |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Multifocal, Lymphocyte          | 1  1     2        1  1  2  2        1     1        1           2  1      |     29  1.4|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Multifocal, Lymphocyte |       1                                                                  |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          |                      1                                                   |      4  1.0|
      Pleura, Inflammation, Acute, Diffuse |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Pleura, Inflammation, Acute,         |                                                                          |            |
          Multifocal                       |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 3  1              1  1     1                    1  1     1  1        1   |     25  1.3|
      Glands, Hyperplasia                  |    1                                                                    1|      3  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic, Focal                  |                                        2                                 |      1  2.0|
      Olfactory Epithelium, Atrophy        |    2                                                     2           2  2|     11  1.9|
      Turbinate, Exudate                   | 3  2                                      2                              |      9  1.9|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Focal                           | 3           2  2                                                        1|      6  1.8|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |    2     2                 1              1                          2   |      9  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Diffuse       |          3  1  1        1                                         1  1   |     10  1.2|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Chronic, Multifocal    | 1                          1              1                             1|     10  1.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Chronic, Multifocal             |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium, Multifocal                |                                                 3                        |      1  3.0|
      Casts Protein, Diffuse               |                                              4                           |      1  4.0|
      Cyst, Single                         |                                                    3                     |      1  3.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Acute, Multifocal      |                                                 3                        |      1  3.0|
      Inflammation, Chronic, Focal         |                         1                                                |      2  1.5|
      Inflammation, Chronic, Multifocal    |                                                                          |      3  1.7|
      Bilateral, Inflammation, Acute, Focal|                                     2                                    |      1  2.0|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Focal                           |                   1                                                      |      1  1.0|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      | 2  1  1  2  2  2     2     1           1  2        2           1     2  2|     29  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2|            |
                                           | 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Artery, Inflammation,     |                                                                          |            |
           Chronic, Multifocal             |                                                          3               |      1  3.0|
      Bilateral, Renal Tubule, Casts       |                                                                          |            |
          Protein, Multifocal              |                                                          1               |      1  1.0|
      Bilateral, Renal Tubule, Concretion, |                                                                          |            |
           Multifocal                      |                                  2                                       |      1  2.0|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Degeneration, Multifocal         |                                                          3               |      1  3.0|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Regeneration, Multifocal         |                                                          1               |      2  1.0|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Vacuolization Cytoplasmic,       |                                                                          |            |
          Multifocal                       |                                                    2                     |      1  2.0|
      Interstitial Tissue, Inflammation,   |                                                                          |            |
           Chronic, Diffuse                |                                              4                           |      1  4.0|
      Renal Tubule, Casts Protein, Diffuse |                               2                                          |      1  2.0|
      Renal Tubule, Concretion, Multifocal |                                                 2                        |      1  2.0|
      Renal Tubule, Degeneration, Focal    |                                                                          |      1  1.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       | 1                                                                        |      2  1.0|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       | 1                                                                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                 +                        |   1        |
      Mucosa, Inflammation, Acute, Diffuse |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                  3                                       |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                            1                                         3   |      3  1.7|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          1  1  1     2              1  1  1  2     1                     |     13  1.3|
      Inflammation, Acute, Focal           |                                                 3                        |      1  3.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Diffuse                         |                                              3                           |      1  3.0|
      Transitional Epithelium,             |                                                                          |            |
          Vacuolization Cytoplasmic,       |                                                                          |            |
          Diffuse                          |                                              2                           |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation, Focal                   |                4                                                         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  M  +  A  +  +  M  +  +  +  M  M  +  M  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                   2                                                      |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                    1                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Acute, Diffuse         |                                                 1     2                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoid Nodule, Hyperplasia, Focal, |                                                                          |             
           Lymphoid                        |                                                                          |             
      Lymphoid Nodule, Hyperplasia,        |                                                                          |             
          Lymphoid, Multifocal             |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |             1                       1     1        1  1        1  1      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Focal,   |                                                                          |             
           Lymphoid                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change, Multifocal             |                1                                                         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                   1           1                                   1      |             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                  1                    1                  |             
      Inflammation, Chronic, Focal         |    1                    1        1  3                                    |             
      Inflammation, Chronic, Multifocal    |             1                                                  2         |             
      Vacuolization Cytoplasmic, Multifocal|                                                                      2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       | 1  2     1           1        2                    1              2  1   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |       2     1     2     1        2     2  2     1     1  1  1  2        1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Abscess, Focal                       |                                                    1                     |             
      Abscess, Multifocal                  |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acanthosis, Focal                    |             2                       3                                    |             
      Acanthosis, Multifocal               |                                                                2         |             
      Hyperkeratosis, Focal                |                                                                          |             
      Inflammation, Acute, Focal           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic,       |                                                                          |             
          Diffuse                          |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
      Bilateral, Hypertrophy, Multifocal   |                   2                                                      |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Diffuse                         |                                                                          |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Multifocal                      | 1  1     1  1     2                 1        2           2  3  2  2  1  2|             
      Spindle Cell, Hyperplasia, Focal     |       1        1     1           2                    1                  |             
      Spindle Cell, Hyperplasia, Multifocal|                         1     1           2        2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                    2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  M  M  +  +  M  M  +  M  +  +  M  +  +  M  M  +  +  +  M  +  M|             
      Cyst, Single                         |                                              2                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic, Focal           |                                                          4               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Ultimobranchial Cyst                 |                   X              X              X           X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm, Focal               |                                                                          |             
      Inflammation, Chronic, Focal         |       1                                                                  |             
      Spermatocele                         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                 +                        |             
      Abscess, Multifocal                  |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Bilateral, Abscess, Multifocal       |                                                 4                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                  1        1                             1|             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Degeneration, Diffuse            |                                                                          |             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Vacuolization Cytoplasmic,       |                                                                          |             
          Diffuse                          |                                        2                                 |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Diffuse                         |                                                    3                     |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Focal                           |                                                                          |             
      Seminiferous Tubule, Mineralization, |                                                                          |             
           Focal                           |                                                                          |             
      Seminiferous Tubule, Mineralization, |                                                                          |             
           Multifocal                      |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid,     |                                                                          |             
           Multifocal                      |                            1                                             |             
      Inguinal, Pigmentation, Focal        |                            1                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |                         1           2  2  2                              |             
      Hyperplasia, Diffuse, Lymphoid       |                   3                                                      |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Hyperplasia, Lymphoid, Multifocal    |             3                                               2        1  1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |                                     1        3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Diffuse, Lymphoid       |                                        3                                 |             
      Hyperplasia, Lymphoid, Multifocal    |                   2        1  1           1                       2  1  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Atrophy, Diffuse                     |                2  2                       1  4     2  2                  |             
      Mineralization, Multifocal           |                                                          1               |             
      Mediastinum, Hemorrhage, Focal       |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                            1                                             |             
      Hyperkeratosis, Focal                |                            1                                             |             
      Inflammation, Chronic, Focal         |                                           1                              |             
      Subcutaneous Tissue, Edema, Diffuse  |                3                             1                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Thalamus, Mineralization, |                                                                          |             
           Multifocal                      |             1     2     1                       2  1           1  2  2   |             
      Thalamus, Mineralization, Focal      |                                                                          |             
      Thalamus, Mineralization, Multifocal |                               1     1  1              1  1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                     1                                    |             
      Hemorrhage, Multifocal               |                                                                          |             
      Alveolar Epithelium, Hypertrophy,    |                                                                          |             
           Focal                           |                                        1                       2         |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Multifocal, Lymphocyte          |    1  1     2     1  2  1     2  2  2  2  1     1  1  1  1  2  1  1     1|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |             1           1                                            1   |             
      Pleura, Inflammation, Chronic, Focal |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             1     2     2     1  1  2              2     1     2  1      |             
      Glands, Hyperplasia                  |    2  1  2  1     3  2  2     2  2  1  2  2  2     2  2  1  1  2  1     2|             
      Olfactory Epithelium, Atrophy        |    3  2  2  1     3  2  3     2  2  2  2  3  3     3  2  2  2  3  2     2|             
      Turbinate, Exudate                   |                   2     2                          3           2         |             
      Turbinate, Hemorrhage, Focal         |                            2                                             |             
      Turbinate, Inflammation, Acute, Focal|                                                                          |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    375                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multifocal                       |    1     1           1                                                   |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |                         1                                      2         |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Focal                           |          1                                         2                     |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |       2                                                  2     1         |             
      Inflammation, Chronic, Focal         |                      1                                                   |             
      Inflammation, Chronic, Multifocal    |             1           2                                                |             
      Peritracheal Tissue, Hemorrhage,     |                                                                          |             
           Diffuse                         |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Single                         |                      1                                                   |             
      Inflammation, Chronic, Focal         |          1           1           1                                       |             
      Inflammation, Chronic, Multifocal    |                               1        3                                 |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |    1  2     1     2     2           2     1     1     1        2         |             
      Bilateral, Renal Tubule, Concretion, |                                                                          |             
           Multifocal                      |                                                                          |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Degeneration, Multifocal         |                                     2                                    |             
      Bilateral, Renal Tubule,             |                                                                          |             
          Regeneration, Multifocal         |                                                 1                 1      |             
      Renal Tubule, Degeneration, Focal    |             1        2                                                   |             
      Renal Tubule, Regeneration, Focal    |       2                                1                                 |             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |    1                                      1              1               |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic, Multifocal          |                2                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                      2  2              1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2|            |
                                           | 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perforation, Focal                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  A  +  M  +  M  +|  36        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                                                             2            |      2  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |       1                                               2                  |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    1                                                                     |      1  1.0|
      Inflammation, Acute, Diffuse         |                                  1                                      2|      4  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Lymphoid Nodule, Hyperplasia, Focal, |                                                                          |            |
           Lymphoid                        |                               2                                          |      1  2.0|
      Lymphoid Nodule, Hyperplasia,        |                                                                          |            |
          Lymphoid, Multifocal             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
      Inflammation, Acute, Focal           |       1           2  1           1              1  1        1           1|     15  1.1|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia, Focal,   |                                                                          |            |
           Lymphoid                        |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fatty Change, Multifocal             |                                                                          |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      3  1.0|
      Inflammation, Acute, Focal           |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |       1                                                                  |      3  1.0|
      Inflammation, Chronic, Focal         |          1                                                     1        1|      7  1.3|
      Inflammation, Chronic, Multifocal    |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |    1                 1                                                   |     10  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2|            |
                                           | 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Lymphocyte                      | 1     2  1              2        1        2  2  2     2        2  2  2   |     25  1.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Abscess, Focal                       |       2           2                                                      |      3  1.7|
      Abscess, Multifocal                  |                                              2                          2|      3  2.0|
      Acanthosis, Focal                    |       2                                                                  |      3  2.3|
      Acanthosis, Multifocal               |                                              2                           |      2  2.0|
      Hyperkeratosis, Focal                |                                  1        2                              |      2  1.5|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic,       |                                                                          |            |
          Diffuse                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy, Focal                   |             1     2                                            2         |      3  1.7|
      Bilateral, Hypertrophy, Multifocal   |                                                                          |      1  2.0|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Diffuse                         |                               3                                          |      1  3.0|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Multifocal                      |    1  1     2     3  2  2  2     2  2  1  2     2  2     1  2  1     2   |     30  1.7|
      Spindle Cell, Hyperplasia, Focal     | 1                                                     1                 1|      8  1.1|
      Spindle Cell, Hyperplasia, Multifocal|                2                             2                           |      6  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  +  M  M  +  +  M  +  +  +  +  M  +  +  M  M  M  +  +  +  +|  27        |
      Cyst, Single                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic, Focal           |                                                                          |      1  4.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                       1                  |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2|            |
                                           | 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Ultimobranchial Cyst                 |       X           X                          X        X     X            |      9     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm, Focal               |                      2                                                   |      1  2.0|
      Inflammation, Chronic, Focal         |             2                                                            |      2  1.5|
      Spermatocele                         |                                                                          |      1     |
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |                         1                                                |      1  1.0|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Multifocal                      |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                    +                                +            |   4        |
      Abscess, Multifocal                  |                                                             4            |      1  4.0|
      Dilatation                           |                            2                                             |      1  2.0|
      Inflammation, Chronic, Diffuse       |                            2                                             |      1  2.0|
      Bilateral, Abscess, Multifocal       |       4                                                                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                              1                           |      4  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Degeneration, Diffuse            |                                        3                                 |      1  3.0|
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Vacuolization Cytoplasmic,       |                                                                          |            |
          Diffuse                          |                               2     2                                    |      3  2.0|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Focal                           |                                                 2                        |      1  2.0|
      Seminiferous Tubule, Mineralization, |                                                                          |            |
           Focal                           |                                                 1                        |      1  1.0|
      Seminiferous Tubule, Mineralization, |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2|            |
                                           | 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid,     |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Inguinal, Pigmentation, Focal        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |                                  1                 2        2            |      7  1.7|
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |      1  3.0|
      Hyperplasia, Focal, Lymphoid         |                   1                                                      |      1  1.0|
      Hyperplasia, Lymphoid, Multifocal    |             1                                   1                 1      |      7  1.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |                         1                                                |      3  1.7|
      Hyperplasia, Diffuse, Lymphoid       |                                                                3         |      2  3.0|
      Hyperplasia, Lymphoid, Multifocal    |                                  1                 2              1  1   |     11  1.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M|  42        |
      Atrophy, Diffuse                     |                            4           4                                 |      8  2.6|
      Mineralization, Multifocal           |                                                                          |      1  1.0|
      Mediastinum, Hemorrhage, Focal       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +     +  +  +     +  +  +  +  +     +  +  +  +  +|  45        |
      Acanthosis, Focal                    |                                                                          |      1  1.0|
      Hyperkeratosis, Focal                |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |       2                                                                  |      2  1.5|
      Subcutaneous Tissue, Edema, Diffuse  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Thalamus, Mineralization, |                                                                          |            |
           Multifocal                      | 1     2  1              1     1  1  1           1           2  2     2  1|     20  1.4|
      Thalamus, Mineralization, Focal      |    1                                                                     |      1  1.0|
      Thalamus, Mineralization, Multifocal |                1           1                       1              1      |      9  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2|            |
                                           | 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                                 1                        |      2  1.0|
      Hemorrhage, Multifocal               | 1                                                                    2   |      2  1.5|
      Alveolar Epithelium, Hypertrophy,    |                                                                          |            |
           Focal                           |                         2        1                                       |      4  1.5|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Multifocal, Lymphocyte          | 1  1  1  2  1     1     1                 2  1     2  2              2  1|     32  1.4|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          | 1                                                           2            |      5  1.2|
      Pleura, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 2  1     1     1  2        2           1        1  2     2  2  1        2|     23  1.5|
      Glands, Hyperplasia                  | 2  2  1  1  1  2  2  2  1  2  1  2     2  2  2  2  2     2  2  2  1     1|     42  1.7|
      Olfactory Epithelium, Atrophy        | 3  3  1  2  2  3  2  2  2  3  1  3     1  2  2  3  3     2  3  2  2     1|     42  2.2|
      Turbinate, Exudate                   | 2                 2        3                       2        2           2|     10  2.2|
      Turbinate, Hemorrhage, Focal         |                                                                          |      1  2.0|
      Turbinate, Inflammation, Acute, Focal|                            1                                             |      1  1.0|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Multifocal                       |                                                                          |      3  1.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         | 2                 2                                2        3            |      6  2.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Focal                           |                                                                          |      2  1.5|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |                               1              2                          2|      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Diffuse       |                               2  1        1  2     1                     |      8  1.5|
      Inflammation, Chronic, Focal         | 1                                                                        |      2  1.0|
      Inflammation, Chronic, Multifocal    |       1  1                                                           1   |      5  1.2|
      Peritracheal Tissue, Hemorrhage,     |                                                                          |            |
           Diffuse                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2|            |
                                           | 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    375                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst, Single                         |             X                    X                    X                  |      4  1.0|
      Inflammation, Chronic, Focal         |       1                                      1                           |      5  1.0|
      Inflammation, Chronic, Multifocal    |                                                 2                        |      3  2.0|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      | 2  3     1        2  1  1     2  1        1        2  1     2     2  2  2|     25  1.6|
      Bilateral, Renal Tubule, Concretion, |                                                                          |            |
           Multifocal                      |                1                                                  1      |      2  1.0|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Degeneration, Multifocal         | 2                                                                        |      2  2.0|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Regeneration, Multifocal         |                                                                          |      2  1.0|
      Renal Tubule, Degeneration, Focal    |    3                                                        2            |      4  2.0|
      Renal Tubule, Regeneration, Focal    |                                                                          |      2  1.5|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       |    2                                                                     |      4  1.3|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic, Multifocal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  A  +  +  +  +  +|  47        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                      1                    1                    2         |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |          1                             1                          1      |      6  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|             
                                           | 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Hemorrhage,   |                                                                          |             
           Focal                           |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute, Diffuse                  |                                              3                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           | 1     1                    1        1  1              1  1  1  1     1   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid,|                                                                          |             
           Multifocal                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Focal,   |                                                                          |             
           Lymphoid                        |    3                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Fatty Change, Multifocal             |                                                                          |             
      Infarct, Focal                       |                                                                         4|             
      Necrosis, Coagulative, Multifocal    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                   1      |             
      Artery, Media, Mineralization,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Duct, Inflammation, Chronic, Focal   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       | 2                       1           1     1                 2            |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |    2  1                          1     2                       2     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                  2                                       |             
      Acanthosis, Multifocal               |                         2  3                                   3  3      |             
      Cyst Epithelial Inclusion, Focal     |                                                                         1|             
      Inflammation, Acute, Focal           |                                                                         1|             
      Inflammation, Acute, Multifocal      |                                                                2         |             
      Inflammation, Chronic, Focal         |                         1  2                                      2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|             
                                           | 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endocardium, Inflammation, Acute,    |                                                                          |             
           Focal                           |                                           2                              |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Diffuse                         |                                              1                           |             
      Epicardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                           1                              |             
      Ventricle Left, Myocardium,          |                                                                          |             
          Hemorrhage, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                   1                                   2                  |             
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |             
           Multifocal                      |       1  1        1  1                 1           1  2           1  2  2|             
      Spindle Cell, Hyperplasia, Diffuse   |                         2                                                |             
      Spindle Cell, Hyperplasia, Focal     | 1                                   1     1                    1         |             
      Spindle Cell, Hyperplasia, Multifocal|                            1                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  +  +  M  M  +  +  M  M  +  M  M  M  M  M  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Craniopharyngeal Duct, Cyst          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                   X                 X     X              X     X        X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Multifocal          |                                                          1               |             
      Inflammation, Chronic, Focal         |                                  1                                       |             
      Vacuolization Cytoplasmic, Diffuse   |                                                       2                  |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bilateral, Atypia Cellular,          |                                                                          |             
          Multifocal                       |                         1              1                          1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|             
                                           | 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |             
           Diffuse                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                    +               |             
      Abscess, Focal                       |                                                                          |             
      Dilatation                           |                                                          2               |             
      Inflammation, Chronic, Diffuse       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |    1     1                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Seminiferous Tubule,      |                                                                          |             
          Vacuolization Cytoplasmic,       |                                                                          |             
          Diffuse                          |                                                                          |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Diffuse                         |                            4                                             |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Focal                           |                                           2                              |             
      Seminiferous Tubule, Vacuolization   |                                                                          |             
          Cytoplasmic, Diffuse             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia, Diffuse |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inguinal, Pigmentation, Multifocal   |                1                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse, Lymphoid       |                                                                   2      |             
      Hyperplasia, Focal, Lymphoid         |                                     1                                    |             
      Hyperplasia, Lymphoid, Multifocal    |                1                       2              2                  |             
      Thrombosis                           |    X                                                                     |             
      Mediastinal, Hyperplasia, Lymphoid,  |                                                                          |             
           Multifocal                      |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |    3                 2                                                   |             
      Hyperplasia, Diffuse, Lymphoid       |                                                                         1|             
      Hyperplasia, Lymphoid, Multifocal    | 1     1  3     1        1                             1                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |             3     2                       3  2                           |             
      Hyperplasia, Diffuse, Lymphoid       |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|             
                                           | 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  I  M  M  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |                +     +     +              +        +     +               |             
      Acanthosis, Multifocal               |                            1                             1               |             
      Hyperkeratosis, Multifocal           |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Back, Ulcer, Focal                   |                                                                          |             
      Hair Follicle, Atrophy, Diffuse      |                            3                                             |             
      Hair Follicle, Atrophy, Focal        |                                                                          |             
      Neck, Edema, Diffuse                 |                2                                                         |             
      Prepuce, Acanthosis, Diffuse         |                                                                          |             
      Prepuce, Inflammation, Chronic,      |                                                                          |             
          Diffuse                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Thalamus, Mineralization, |                                                                          |             
           Multifocal                      | 1        1           1  1  1     1     1              1  1  1  1  1  1   |             
      Cerebellum, Hemorrhage, Multifocal   |                                                                          |             
      Olfactory Lobe, Mineralization, Focal|             2                                                            |             
      Thalamus, Mineralization, Multifocal |    1  1           1                                1                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                   +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                +                                                         |             
      Hemorrhage                           |                3                                                         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Diffuse                  |                            3                                             |             
      Foreign Body                         |                               2                                          |             
      Hemorrhage, Multifocal               |                1              3                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Hypertrophy,    |                                                                          |             
           Focal                           |                                                             2            |             
      Alveolus, Foreign Body, Multifocal   |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Multifocal, Lymphocyte          | 1        1              1  1        1                 1     1     1     2|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Multifocal, Lymphocyte          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    1     2     2  2        2     2     2           2     1  1  3  1  1  1|             
      Glands, Hyperplasia                  | 2  2  2  2     2  2  3  3  3  2  3  3  3           3  2  3  3  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|             
                                           | 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic, Diffuse                |                                  3                                       |             
      Olfactory Epithelium, Atrophy        | 3  2  3  3     3  3  4  3  4  3  3  3  3           4  3  3  3  4  4  3  3|             
      Turbinate, Congestion, Diffuse       |    3                                                                     |             
      Turbinate, Exudate                   |                            2                                   2  2     1|             
      Turbinate, Foreign Body              |                                                                          |             
      Turbinate, Hemorrhage, Diffuse       |    3           3  3                                                      |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
          Diffuse                          |          1                                                               |             
      Turbinate, Inflammation, Acute, Focal|                                        1                                 |             
      Turbinate, Inflammation, Acute,      |                                                                          |             
          Multifocal                       |       1                    2  1                    1     1  1  2  1  1  1|             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |                                                                          |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                   2                                               3  1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                   1        1        1                       1  1  1  1  1|             
      Peritracheal Tissue, Foreign Body,   |                                                                          |             
           Multifocal                      |                                              2                           |             
      Peritracheal Tissue, Hemorrhage,     |                                                                          |             
           Diffuse                         |                3                                                         |             
      Peritracheal Tissue, Hemorrhage,     |                                                                          |             
           Multifocal                      |                                              3                           |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute, Multifocal               |                                              3                           |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Chronic, Focal                  |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                          1               |             
      Cyst, Single                         |                                           X                              |             
      Inflammation, Chronic, Focal         |    1     1                             1                 1  1            |             
      Inflammation, Chronic, Multifocal    |                                                                      1   |             
      Bilateral, Cyst, Multiple            |                                                                          |             
      Bilateral, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      | 1     1                    1        1              1  1        1  1     1|             
      Bilateral, Renal Tubule,             |                                                                          |             
          Degeneration, Multifocal         |                      3                                                   |             
      Bilateral, Renal Tubule,             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|             
                                           | 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    750                                    | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Regeneration, Multifocal         |    1                                                                 1   |             
      Renal Tubule, Degeneration, Focal    |                            1                                             |             
      Renal Tubule, Degeneration,          |                                                                          |             
          Multifocal                       |                                                                         1|             
      Renal Tubule, Regeneration, Focal    |                            1                          1                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3|            |
                                           | 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Periesophageal Tissue, Hemorrhage,   |                                                                          |            |
           Focal                           | 4                                                                        |      1  4.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Acute, Diffuse                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  M  +  A  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +|  43        |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                                           2                              |      1  2.0|
      Inflammation, Acute, Focal           |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +|  44        |
      Inflammation, Acute, Focal           |          1  1     1     1              1        1     1           1      |     18  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Peyer's Patch, Hyperplasia, Lymphoid,|                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia, Focal,   |                                                                          |            |
           Lymphoid                        |                                                          3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fatty Change, Multifocal             |                                                             3            |      1  3.0|
      Infarct, Focal                       |                                                                          |      1  4.0|
      Necrosis, Coagulative, Multifocal    |                                  3                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Atrophy, Focal                       |                                                                         1|      2  1.0|
      Artery, Media, Mineralization,       |                                                                          |            |
          Multifocal                       |                                              3                           |      1  3.0|
      Duct, Inflammation, Chronic, Focal   |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                      1                             1                     |      7  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       1                 1              1  1                       1      |     11  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Acanthosis, Focal                    |       2     3                          2                             1   |      5  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3|            |
                                           | 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis, Multifocal               |                                                       3           1      |      6  2.5|
      Cyst Epithelial Inclusion, Focal     |                                                                          |      1  1.0|
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |             1                                                     1  2   |      6  1.5|
      Inflammation, Chronic, Multifocal    |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Inflammation, Acute, Focal           |                                                    2  3                  |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endocardium, Inflammation, Acute,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Diffuse                         |                                                                          |      1  1.0|
      Epicardium, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                2                                                         |      2  1.5|
      Ventricle Left, Myocardium,          |                                                                          |            |
          Hemorrhage, Focal                | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy, Focal                   |                                                                          |      2  1.5|
      Bilateral, Spindle Cell, Hyperplasia,|                                                                          |            |
           Multifocal                      |    1  1           1        1     1  1  1     1     1  1     1  1     1   |     23  1.1|
      Spindle Cell, Hyperplasia, Diffuse   |                                                                          |      1  2.0|
      Spindle Cell, Hyperplasia, Focal     |                                                                         2|      5  1.2|
      Spindle Cell, Hyperplasia, Multifocal|                      2  1                                1               |      4  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  M  +  M  +  M  M  +  M  +  +  +  M  +  +  +  +  M  +  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Craniopharyngeal Duct, Cyst          |                                           X                              |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ultimobranchial Cyst                 |                                                                      X   |      7     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3|            |
                                           | 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular, Multifocal          |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |                                                    2                     |      2  1.5|
      Vacuolization Cytoplasmic, Diffuse   |                                                                      1   |      2  1.5|
      Vacuolization Cytoplasmic, Focal     |                                     1                                    |      1  1.0|
      Bilateral, Atypia Cellular,          |                                                                          |            |
          Multifocal                       |             2                                                            |      4  1.3|
      Bilateral, Vacuolization Cytoplasmic,|                                                                          |            |
           Diffuse                         |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                      +   |   3        |
      Abscess, Focal                       |                                                                      4   |      1  4.0|
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      2  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Seminiferous Tubule,      |                                                                          |            |
          Vacuolization Cytoplasmic,       |                                                                          |            |
          Diffuse                          |                                  2                                       |      1  2.0|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Diffuse                         |                                                                          |      1  4.0|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Seminiferous Tubule, Vacuolization   |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                      2   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erythroid Cell, Hyperplasia, Diffuse |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inguinal, Pigmentation, Multifocal   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |      1  2.0|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid, Multifocal    |    2        2              1              1        2  1           1      |     10  1.5|
      Thrombosis                           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3|            |
                                           | 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Hyperplasia, Lymphoid,  |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |    2        2        2              3                                    |      6  2.3|
      Hyperplasia, Diffuse, Lymphoid       |                                                    3                     |      2  2.0|
      Hyperplasia, Lymphoid, Multifocal    |    1     2                    1           1                              |     10  1.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +|  44        |
      Atrophy, Diffuse                     |                                                             4            |      5  2.8|
      Hyperplasia, Diffuse, Lymphoid       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  +  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +                 +  +  +  +  +                 +            |  15        |
      Acanthosis, Multifocal               |       1                          2        1                              |      5  1.2|
      Hyperkeratosis, Multifocal           |       1                                                                  |      1  1.0|
      Inflammation, Chronic, Diffuse       |                                  2                                       |      1  2.0|
      Inflammation, Chronic, Focal         |       1                                                                  |      1  1.0|
      Back, Ulcer, Focal                   |                                     4                                    |      1  4.0|
      Hair Follicle, Atrophy, Diffuse      |                                                                          |      1  3.0|
      Hair Follicle, Atrophy, Focal        |    1                                1                       2            |      3  1.3|
      Neck, Edema, Diffuse                 |                                                                          |      1  2.0|
      Prepuce, Acanthosis, Diffuse         |             1                                                            |      1  1.0|
      Prepuce, Inflammation, Chronic,      |                                                                          |            |
          Diffuse                          |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Thalamus, Mineralization, |                                                                          |            |
           Multifocal                      |          1        1     1  1     1     1     1           1              1|     22  1.0|
      Cerebellum, Hemorrhage, Multifocal   |                3                                                         |      1  3.0|
      Olfactory Lobe, Mineralization, Focal|                                                                          |      1  2.0|
      Thalamus, Mineralization, Multifocal |                                     1     1        1                     |      7  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +              +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3|            |
                                           | 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Diffuse                  |                                                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               | 4                                                                        |      3  2.7|
      Alveolar Epithelium, Hyperplasia     |                         4                                                |      1  4.0|
      Alveolar Epithelium, Hypertrophy,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolus, Foreign Body, Multifocal   | 3                                                                        |      1  3.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Multifocal, Lymphocyte          |    2  1     1     1     1  1  1  1  1  1              1  1               |     21  1.1|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Multifocal, Lymphocyte          |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         | 3  1  1  1  2              1     1     1     1  1  1     1               |     26  1.5|
      Glands, Hyperplasia                  |    3  3  3  4     3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  3|     44  2.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic, Diffuse                |                                                                          |      1  3.0|
      Olfactory Epithelium, Atrophy        |    4  3  4  4     4  4  4  4  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|     44  3.3|
      Turbinate, Congestion, Diffuse       |                                                                          |      1  3.0|
      Turbinate, Exudate                   |    2        2                          1        3                        |      8  1.9|
      Turbinate, Foreign Body              |                                           1                              |      1  1.0|
      Turbinate, Hemorrhage, Diffuse       | 2              3     3                                                   |      6  2.8|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Diffuse                          |                                                                          |      1  1.0|
      Turbinate, Inflammation, Acute, Focal|                                                                         1|      2  1.0|
      Turbinate, Inflammation, Acute,      |                                                                          |            |
          Multifocal                       |    1  1  1  1     1  1  2  1  1     1     1     2  2  1        1  1     1|     27  1.2|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         |             2                                                            |      1  2.0|
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |    2                                   1                                 |      6  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Inflammation, Chronic, Multifocal    |       1                    1           1                                 |     11  1.0|
      Peritracheal Tissue, Foreign Body,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Peritracheal Tissue, Hemorrhage,     |                                                                          |            |
           Diffuse                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05032-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                              CARVONE                                          Date: 04/17/97  
Route: GAVAGE                                                                                                     Time: 13:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3|            |
                                           | 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    750                                    | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Peritracheal Tissue, Hemorrhage,     |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Acute, Multifocal               |                                                                          |      1  3.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst, Multiple                       |                                                                          |      1  1.0|
      Cyst, Single                         |                                                                          |      1     |
      Inflammation, Chronic, Focal         |                            1                                         1   |      7  1.0|
      Inflammation, Chronic, Multifocal    |                                        1              1                  |      3  1.0|
      Bilateral, Cyst, Multiple            |                                                                   2      |      1  2.0|
      Bilateral, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |       1  1  1           2        1        1     1  1     1              1|     19  1.1|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Degeneration, Multifocal         |                                                                          |      1  3.0|
      Bilateral, Renal Tubule,             |                                                                          |            |
          Regeneration, Multifocal         |                                                                          |      2  1.0|
      Renal Tubule, Degeneration, Focal    |                                                                          |      1  1.0|
      Renal Tubule, Degeneration,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Renal Tubule, Regeneration, Focal    |                                           1                              |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Dilatation                           |                                        3                                 |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                         1                                      1     1   |      3  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2                                               1                     |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.