National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2073

TR 386 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         TETRANITROMETHANE


NTP Experiment-Test: 05072-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51




       Facility:  Midwest Research Institute

       Chemical CAS #:  509-14-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      5            4           10                                                  
    Accidently Killed                                  2            1                                                               
    Moribund Sacrifice                                12           17           16                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           27           23                                                  
    Natural Death                                      1                                                                            
    Moribund Sacrifice                                              1            1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (40)         (36)                                                
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (3%)                                                          
   Intestine Large, Cecum                             (47)         (44)         (45)                                                
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (2%)       1 (2%)                                             
   Intestine Large, Colon                             (49)         (47)         (46)                                                
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (2%)                                                          
   Intestine Small, Jejunum                           (45)         (46)         (44)                                                
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
   Liver                                              (49)         (50)         (50)                                                
      Basophilic Focus                                 1 (2%)                    1 (2%)                                             
      Cytomegaly                                                    1 (2%)                                                          
      Eosinophilic Focus                               3 (6%)                                                                       
      Fatty Change, Focal                                           1 (2%)                                                          
      Granuloma, Multifocal                            1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)      10 (20%)      7 (14%)                                            
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    4 (8%)       2 (4%)       6 (12%)                                            
      Inflammation, Acute, Multifocal                               1 (2%)                                                          
      Inflammation, Multifocal, Subacute               4 (8%)       3 (6%)                                                          
      Necrosis, Acute, Multifocal                      3 (6%)       4 (8%)       3 (6%)                                             
      Necrosis, Chronic, Multifocal                                 1 (2%)                                                          
      Necrosis, Focal, Subacute                        2 (4%)       2 (4%)                                                          
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal                         1 (2%)                                                          
      Bile Duct, Hyperplasia, Multifocal                                         1 (2%)                                             
      Centrilobular, Fatty Change, Diffuse                                       1 (2%)                                             
      Centrilobular, Necrosis, Acute, Diffuse                                    1 (2%)                                             
      Periportal, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                                   1 (2%)                                                          
      Portal, Inflammation, Chronic, Multifocal                     2 (4%)                                                          
      Right Lateral Lobe, Hepatodiaphragmatic                                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
          Nodule                                       1 (2%)                    1 (2%)                                             
      Vein, Thrombosis                                                           1 (2%)                                             
   Mesentery                                          (3)          (1)          (5)                                                 
      Infiltration Cellular, Multifocal, Lymphocyte    3 (100%)                  1 (20%)                                            
      Inflammation, Suppurative                                                  1 (20%)                                            
   Pancreas                                           (49)         (50)         (50)                                                
      Abscess, Multiple                                                          1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte   10 (20%)      9 (18%)      7 (14%)                                            
      Acinus, Atrophy, Diffuse                                      1 (2%)       1 (2%)                                             
      Acinus, Atrophy, Multifocal                      1 (2%)                                                                       
   Salivary Glands                                    (48)         (50)         (50)                                                
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)       1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte   26 (54%)     17 (34%)     19 (38%)                                            
   Stomach, Forestomach                               (48)         (50)         (49)                                                
      Abscess                                                       1 (2%)                                                          
      Epithelium, Hyperplasia, Diffuse                              1 (2%)                                                          
      Epithelium, Hyperplasia, Focal                   2 (4%)                                                                       
      Epithelium, Hyperplasia, Multifocal              1 (2%)                                                                       
   Stomach, Glandular                                 (47)         (49)         (49)                                                
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)       1 (2%)                                                          
      Necrosis, Acute, Multifocal                                   1 (2%)                                                          
      Mucosa, Degeneration, Multifocal                              1 (2%)                                                          
   Tooth                                              (2)                       (2)                                                 
      Abscess                                          1 (50%)                                                                      
      Developmental Malformation                                                 1 (50%)                                            
      Inflammation, Chronic Active                     1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (2)                                                              
      Aorta, Inflammation, Chronic Active, Focal                    1 (50%)                                                         
      Artery, Inflammation, Chronic, Multifocal                     1 (50%)                                                         
   Heart                                              (47)         (50)         (50)                                                
      Cardiomyopathy                                   1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)       1 (2%)                                                          
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                             1 (2%)                                                          
      Mineralization, Multifocal                                    1 (2%)                                                          
      Necrosis, Acute, Focal                                        1 (2%)                                                          
      Pigmentation                                                               1 (2%)                                             
      Artery, Mineralization, Multifocal                                         1 (2%)                                             
      Atrium Left, Thrombosis                                       1 (2%)       1 (2%)                                             
      Epicardium, Inflammation, Chronic, Focal                                   1 (2%)                                             
      Epicardium, Inflammation, Chronic Active,                                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
           Focal                                       1 (2%)                    1 (2%)                                             
      Epicardium, Inflammation, Suppurative                                      1 (2%)                                             
      Mitral Valve, Bacterium                          2 (4%)                                                                       
      Mitral Valve, Inflammation, Chronic Active       2 (4%)                                                                       
      Valve, Pigmentation                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (49)         (50)                                                
      Capsule, Accessory Adrenal Cortical Nodule       1 (2%)       2 (4%)       1 (2%)                                             
      Capsule, Accessory Adrenal Cortical Nodule,                                                                                   
           Multiple                                    1 (2%)                                                                       
      Capsule, Inflammation, Chronic Active,                                                                                        
          Suppurative                                                            1 (2%)                                             
      Subcapsular, Hyperplasia, Diffuse                4 (8%)       4 (8%)       4 (8%)                                             
      Subcapsular, Hyperplasia, Focal                  1 (2%)                    1 (2%)                                             
      Subcapsular, Hyperplasia, Multifocal            43 (88%)     43 (88%)     43 (86%)                                            
   Adrenal Gland, Cortex                              (49)         (48)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Hemorrhage, Acute                                                          1 (2%)                                             
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Hyperplasia, Multifocal                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (48)         (46)         (47)                                                
      Hyperplasia, Focal                               2 (4%)                    2 (4%)                                             
   Islets, Pancreatic                                 (49)         (50)         (49)                                                
      Hyperplasia, Focal                                            3 (6%)       3 (6%)                                             
      Hyperplasia, Multifocal                         10 (20%)      2 (4%)       3 (6%)                                             
      Hypoplasia                                                    1 (2%)                                                          
   Pituitary Gland                                    (49)         (49)         (48)                                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                             2 (4%)                    1 (2%)                                             
      Pars Distalis, Angiectasis                       8 (16%)      7 (14%)      3 (6%)                                             
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                4 (8%)       4 (8%)       4 (8%)                                             
      Pars Distalis, Hyperplasia, Multifocal                        2 (4%)                                                          
      Pars Distalis, Hypertrophy, Focal                5 (10%)      1 (2%)                                                          
      Pars Distalis, Hypertrophy, Multifocal           1 (2%)                                                                       
   Thyroid Gland                                      (48)         (50)         (50)                                                
      Cyst                                                          2 (4%)       1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)       2 (4%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    3 (6%)       1 (2%)                                                          
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Focal                                  1 (2%)       2 (4%)                                             
      Inflammation, Chronic, Multifocal                4 (8%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic Active, Focal              1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active, Multifocal         2 (4%)       2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      C-Cell, Hyperplasia, Focal                       1 (2%)                                                                       
      Follicle, Cyst                                                1 (2%)                                                          
      Follicle, Cyst, Multiple                         1 (2%)       2 (4%)       3 (6%)                                             
      Follicular Cell, Hyperplasia, Diffuse            1 (2%)                                                                       
      Follicular Cell, Hyperplasia, Focal              1 (2%)       3 (6%)       2 (4%)                                             
      Follicular Cell, Hyperplasia, Multifocal         7 (15%)      9 (18%)      5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (2)          (1)          (1)                                                 
      Atrophy                                          1 (50%)                                                                      
      Cyst                                                                       1 (100%)                                           
      Cyst, Multiple                                   1 (50%)      1 (100%)                                                        
   Ovary                                              (48)         (49)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Angiectasis, Focal                                                         1 (2%)                                             
      Cyst                                             8 (17%)      8 (16%)      9 (18%)                                            
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Pigmentation                                                  1 (2%)       1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Interstitium, Hyperplasia                        1 (2%)                                                                       
      Periovarian Tissue, Infiltration Cellular,                                                                                    
           Lymphocyte                                  3 (6%)       1 (2%)       2 (4%)                                             
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active                                                                 1 (2%)                                             
   Uterus                                             (49)         (50)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Abscess, Multiple                                                          1 (2%)                                             
      Adenomyosis                                      1 (2%)                                                                       
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis, Multifocal                          1 (2%)                                                                       
      Cyst                                                          1 (2%)       3 (6%)                                             
      Dilatation                                                    2 (4%)       1 (2%)                                             
      Hyperplasia, Atypical, Focal, Glandular                       1 (2%)                                                          
      Hyperplasia, Cystic                              1 (2%)       3 (6%)       3 (6%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Thrombosis, Multiple                                                       1 (2%)                                             
      Bilateral, Hyperplasia, Cystic                  33 (67%)     40 (80%)     35 (70%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (50)                                                
      Atrophy, Diffuse                                              1 (2%)                                                          
      Atrophy, Focal                                                             1 (2%)                                             
      Myeloid Cell, Hyperplasia                                     1 (2%)       3 (6%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Hemorrhage, Acute                                                          1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                  2 (4%)       3 (6%)                                                          
      Lumbar, Hyperplasia, Lymphoid                                              1 (2%)                                             
      Mediastinal, Hyperplasia                                      1 (2%)       1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)       1 (2%)       4 (8%)                                             
      Pancreatic, Hemorrhage, Acute                                              1 (2%)                                             
      Renal, Hematopoietic Cell Proliferation                       1 (2%)                                                          
      Renal, Hemorrhage, Subacute                      1 (2%)                                                                       
      Renal, Hyperplasia, Lymphoid                     1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (43)         (45)                                                
      Cyst                                                          3 (7%)                                                          
      Hemorrhage, Acute                                             2 (5%)                                                          
      Hemorrhage, Subacute                             1 (2%)                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                            6 (13%)      6 (14%)      7 (16%)                                            
      Hyperplasia, Re Cell                                                       1 (2%)                                             
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                    2 (4%)                                             
   Lymph Node, Mesenteric                             (41)         (36)         (37)                                                
      Angiectasis                                      1 (2%)                                                                       
      Depletion Lymphoid                               1 (2%)       1 (3%)                                                          
      Hematopoietic Cell Proliferation                 4 (10%)      4 (11%)      5 (14%)                                            
      Hemorrhage, Acute                               10 (24%)      4 (11%)      9 (24%)                                            
      Hemorrhage, Subacute                             2 (5%)       1 (3%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       3 (8%)                                                          
   Spleen                                             (48)         (49)         (50)                                                
      Ectasia, Focal                                                             1 (2%)                                             
      Edema                                            1 (2%)                                                                       
      Hematopoietic Cell Proliferation                10 (21%)      9 (18%)     14 (28%)                                            
      Hyperplasia, Lymphoid                            2 (4%)       5 (10%)      5 (10%)                                            
      Infarct                                          1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)       2 (4%)                                                          
      Capsule, Ectopic Tissue                                       1 (2%)                                                          
      Capsule, Inflammation, Chronic Active                                      1 (2%)                                             
   Thymus                                             (48)         (44)         (32)                                                
      Angiectasis, Focal                               1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Depletion Lymphoid                               4 (8%)       6 (14%)      6 (19%)                                            
      Ectopic Parathyroid Gland                        3 (6%)       1 (2%)       2 (6%)                                             
      Hyperplasia, Lymphoid                            3 (6%)       6 (14%)      4 (13%)                                            
      Metaplasia, Focal, Osseous                                                 1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (46)         (45)                                                
      Ectasia, Multifocal                              8 (17%)      4 (9%)       2 (4%)                                             
      Hyperplasia, Diffuse                             7 (15%)      8 (17%)      6 (13%)                                            
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
   Skin                                               (48)         (46)         (50)                                                
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Hair Follicle, Inflammation, Chronic Active                   1 (2%)                                                          
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)                                                
      Fibrous Osteodystrophy                          12 (24%)     10 (20%)     10 (20%)                                            
      Osteoporosis, Focal                                           1 (2%)                                                          
   Skeletal Muscle                                    (2)          (1)                                                              
      Inflammation, Chronic, Focal                     1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Compression                                      9 (18%)      2 (4%)       8 (16%)                                            
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Hydrocephalus                                    2 (4%)                    1 (2%)                                             
      Mineralization, Multifocal                      26 (53%)     26 (52%)     20 (40%)                                            
      Meninges, Infiltration Cellular, Multifocal,                                                                                  
           Lymphocyte                                                            1 (2%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Lymphocyte                       2 (4%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (46)         (45)         (47)                                                
      Exudate                                                                    1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    2 (4%)                    1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
   Lung                                               (49)         (50)         (50)                                                
      Embolus Tumor, Multiple                                                    1 (2%)                                             
      Hemorrhage, Acute, Focal                                                   1 (2%)                                             
      Hemorrhage, Acute, Multifocal                                 1 (2%)                                                          
      Hemorrhage, Multifocal, Subacute                              1 (2%)                                                          
      Infiltration Cellular, Diffuse, Lymphocyte                    1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Lymphocyte   16 (33%)      2 (4%)       2 (4%)                                             
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Pigmentation, Diffuse, Hemosiderin                            1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)      13 (26%)                                                         
      Alveolar Epithelium, Hyperplasia, Multifocal                  7 (14%)     41 (82%)                                            
      Alveolus, Infiltration Cellular, Diffuse,                                                                                     
           Histiocyte                                  1 (2%)       2 (4%)                                                          
      Alveolus, Infiltration Cellular, Focal,                                                                                       
          Histiocyte                                   1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                  1 (2%)       8 (16%)     32 (64%)                                            
      Bronchiole, Hyperplasia, Focal                                2 (4%)                                                          
      Bronchiole, Hyperplasia, Multifocal                           5 (10%)     41 (82%)                                            
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Focal                                                    1 (2%)                                                          
      Mediastinum, Infiltration Cellular,                                                                                           
          Multifocal, Lymphocyte                                                 2 (4%)                                             
      Mediastinum, Inflammation, Chronic                                         1 (2%)                                             
      Pleura, Hyperplasia                                                        1 (2%)                                             
      Pleura, Infiltration Cellular, Lymphocyte                     2 (4%)                                                          
   Nose                                               (49)         (50)         (50)                                                
      Lumen, Exudate                                   3 (6%)      30 (60%)     33 (66%)                                            
      Lumen, Foreign Body                                           1 (2%)                                                          
      Mucosa, Inflammation, Chronic                    2 (4%)       1 (2%)                                                          
      Mucosa, Inflammation, Chronic Active             9 (18%)     10 (20%)     23 (46%)                                            
      Mucosa, Ulcer                                    1 (2%)       2 (4%)                                                          
      Nasolacrimal Duct, Exudate                                    1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic                      1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)       1 (2%)                                                          
      Olfactory Epithelium, Atrophy                    2 (4%)       4 (8%)       2 (4%)                                             
      Respiratory Epithelium, Hyperplasia              2 (4%)       5 (10%)     17 (34%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                  2 (4%)       8 (16%)                                            
      Sinus, Hyperplasia                                                         1 (2%)                                             
      Sinus, Inflammation, Chronic Active                                        1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Chronic                            2 (4%)       2 (4%)                                                          
      Inflammation, Chronic Active                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)                                                              
      Abscess                                                       1 (50%)                                                         
      Atrophy                                                       1 (50%)                                                         
   Harderian Gland                                    (1)          (1)          (1)                                                 
      Inflammation, Chronic Active                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Cytoplasmic Alteration, Multifocal               1 (2%)                                                                       
      Infarct                                                       3 (6%)                                                          
      Infiltration Cellular, Lymphocyte               20 (41%)     14 (28%)     15 (30%)                                            
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Metaplasia, Focal, Osseous                       1 (2%)                    1 (2%)                                             
      Nephropathy, Chronic                                          2 (4%)                                                          
      Pigmentation, Diffuse                                                      1 (2%)                                             
      Cortex, Mineralization, Multifocal                                         1 (2%)                                             
      Interstitial Tissue, Inflammation, Chronic,                                                                                   
           Multifocal                                                            2 (4%)                                             
      Renal Tubule, Hyperplasia, Focal                                           1 (2%)                                             
      Renal Tubule, Necrosis, Acute, Multifocal                                  1 (2%)                                             
   Urinary Bladder                                    (48)         (49)         (47)                                                
      Infiltration Cellular, Focal, Lymphocyte         3 (6%)                    1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte   18 (38%)     17 (35%)     17 (36%)                                            
      Artery, Inflammation, Chronic Active,                                                                                         
          Multifocal                                                             1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           19           17                                                  
    Natural Death                                      4            3           18                                                  
    Accidently Killed                                               2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           26           15                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (40)         (39)         (31)                                                
      Ectasia                                                       1 (3%)                                                          
      Infiltration Cellular, Focal, Lymphocyte                                   2 (6%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    2 (5%)       3 (8%)                                                          
   Intestine Large, Cecum                             (48)         (47)         (40)                                                
      Peyer's Patch, Hyperplasia, Lymphoid             6 (13%)      3 (6%)                                                          
   Intestine Large, Colon                             (49)         (46)         (48)                                                
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (2%)                                             
   Intestine Small, Duodenum                          (49)         (48)         (44)                                                
      Ectopic Tissue                                                1 (2%)                                                          
      Lumen, Hemorrhage, Acute                         1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (47)         (44)                                                
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (46)         (42)                                                
      Hyperplasia                                                                1 (2%)                                             
      Lumen, Hemorrhage, Acute                         1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Multifocal                                       1 (2%)                                                          
      Basophilic Focus                                 2 (4%)       2 (4%)       2 (4%)                                             
      Basophilic Focus, Multiple                       1 (2%)                                                                       
      Cytomegaly, Multifocal                           1 (2%)                                                                       
      Cytoplasmic Alteration, Multifocal                                         1 (2%)                                             
      Eosinophilic Focus                               1 (2%)                    1 (2%)                                             
      Fatty Change, Focal                              1 (2%)                                                                       
      Fatty Change, Multifocal                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       2 (4%)       2 (4%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Focal                                            1 (2%)                                                          
      Hyperplasia, Multifocal, Nodular                 1 (2%)                                                                       
      Infarct                                          2 (4%)       5 (10%)      2 (4%)                                             
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)       1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    4 (8%)       1 (2%)       3 (6%)                                             
      Inflammation, Chronic, Multifocal                1 (2%)       3 (6%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Granulomatous, Multifocal                       1 (2%)                                                          
      Inflammation, Multifocal, Subacute               2 (4%)       4 (8%)                                                          
      Mitotic Alteration                                            1 (2%)                                                          
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Acute, Multifocal                      3 (6%)       3 (6%)       2 (4%)                                             
      Necrosis, Chronic, Multifocal                                 1 (2%)                                                          
      Pigmentation, Multifocal                                      1 (2%)                                                          
      Thrombosis                                                                 1 (2%)                                             
      Artery, Mineralization, Multifocal                            1 (2%)                                                          
      Bile Duct, Hyperplasia, Multifocal               4 (8%)       3 (6%)       3 (6%)                                             
      Centrilobular, Fatty Change, Multifocal          2 (4%)                    1 (2%)                                             
      Centrilobular, Necrosis, Acute, Multifocal                                 1 (2%)                                             
      Centrilobular, Necrosis, Diffuse                 1 (2%)                    1 (2%)                                             
      Hepatocyte, Atrophy, Multifocal                               1 (2%)                                                          
      Kupffer Cell, Hyperplasia, Multifocal                                      1 (2%)                                             
      Oval Cell, Hyperplasia                           1 (2%)                                                                       
   Mesentery                                                       (3)          (1)                                                 
      Angiectasis, Multifocal                                       1 (33%)                                                         
      Fat, Inflammation, Chronic                                    1 (33%)                                                         
   Pancreas                                           (50)         (49)         (49)                                                
      Hyperplasia, Focal                               1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                                       1 (2%)                                             
      Duct, Cyst                                       1 (2%)                                                                       
      Duct, Dilatation                                                           1 (2%)                                             
   Salivary Glands                                    (50)         (48)         (50)                                                
      Infiltration Cellular, Multifocal, Lymphocyte   25 (50%)     21 (44%)      7 (14%)                                            
   Stomach, Forestomach                               (46)         (49)         (50)                                                
      Inflammation, Chronic Active, Focal              1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia, Diffuse                 1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
   Stomach, Glandular                                 (47)         (49)         (49)                                                
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Mucosa, Mineralization                           1 (2%)                    1 (2%)                                             
   Tooth                                              (3)          (2)          (8)                                                 
      Abscess                                                       1 (50%)                                                         
      Dysplasia                                        2 (67%)      2 (100%)     5 (63%)                                            
      Inflammation, Acute                                                        1 (13%)                                            
      Inflammation, Chronic                                                      2 (25%)                                            
      Inflammation, Chronic Active                     1 (33%)                   3 (38%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
      Artery, Inflammation, Chronic, Multifocal        1 (100%)                                                                     
      Mesenteric Artery, Inflammation, Chronic                      1 (100%)                                                        
      Mesenteric Artery, Thrombosis                                 1 (100%)                                                        
      Renal Artery, Inflammation, Chronic,                                                                                          
          Multifocal                                                1 (100%)                                                        
   Heart                                              (49)         (50)         (50)                                                
      Cardiomyopathy                                                2 (4%)                                                          
      Inflammation, Acute, Multifocal                                            1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
      Aortic Valve, Inflammation, Chronic Active,                                                                                   
           Focal                                                    1 (2%)                                                          
      Epicardium, Hyperplasia, Focal                                1 (2%)                                                          
      Mitral Valve, Bacterium                                                    1 (2%)                                             
      Mitral Valve, Inflammation, Focal, Subacute                   1 (2%)                                                          
      Perivascular, Granuloma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Capsule, Accessory Adrenal Cortical Nodule                                 3 (6%)                                             
      Subcapsular, Hyperplasia, Focal                  4 (8%)       4 (8%)       3 (6%)                                             
      Subcapsular, Hyperplasia, Multifocal            32 (64%)     27 (55%)     28 (56%)                                            
   Adrenal Gland, Cortex                              (49)         (47)         (50)                                                
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Focal                               5 (10%)      7 (15%)      4 (8%)                                             
      Hyperplasia, Multifocal                          1 (2%)       3 (6%)                                                          
      Hypertrophy, Focal                               6 (12%)      3 (6%)       7 (14%)                                            
      Hypertrophy, Multifocal                          6 (12%)      3 (6%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (47)         (43)         (47)                                                
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Hyperplasia, Multifocal                                       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (49)         (48)                                                
      Hyperplasia, Focal                               1 (2%)       2 (4%)                                                          
      Hyperplasia, Multifocal                         18 (36%)      7 (14%)     23 (48%)                                            
   Pituitary Gland                                    (48)         (48)         (48)                                                
      Pars Distalis, Cyst                              1 (2%)       1 (2%)                                                          
      Pars Distalis, Cyst, Multiple                                 1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal                1 (2%)                                                                       
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
      Follicle, Cyst                                                1 (2%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Cyst, Multiple                         3 (6%)                    2 (4%)                                             
      Follicular Cell, Hyperplasia, Focal              1 (2%)                    2 (4%)                                             
      Follicular Cell, Hyperplasia, Multifocal         3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Granuloma                                                     1 (2%)                                                          
      Granuloma Sperm                                               1 (2%)                                                          
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
   Penis                                                           (1)          (2)                                                 
      Inflammation, Chronic Active                                               2 (100%)                                           
   Preputial Gland                                    (3)          (4)          (4)                                                 
      Abscess                                                       2 (50%)                                                         
      Atrophy                                                                    2 (50%)                                            
      Ectasia                                          2 (67%)      1 (25%)      3 (75%)                                            
      Inflammation, Chronic                            1 (33%)      1 (25%)      2 (50%)                                            
   Prostate                                           (48)         (48)         (46)                                                
      Ectasia, Multifocal                              1 (2%)       1 (2%)                                                          
      Granuloma                                                     1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (2%)                                                          
      Inflammation, Acute, Suppurative                                           1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (4%)                                             
      Serosa, Inflammation, Acute, Focal,                                                                                           
          Suppurative                                               1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (49)                                                
      Abscess                                                                    1 (2%)                                             
      Ectasia                                                       3 (6%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Hyperplasia, Diffuse                       2 (4%)                                                          
      Seminiferous Tubule, Atrophy, Multifocal                      8 (16%)                                                         
      Seminiferous Tubule, Degeneration, Multifocal                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (49)                                                
      Hyperplasia, Focal, Re Cell                                                1 (2%)                                             
      Metaplasia, Focal, Osseous                                    1 (2%)                                                          
      Myeloid Cell, Hyperplasia                                     1 (2%)       2 (4%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Bronchial, Hyperplasia, Lymphoid                                           1 (2%)                                             
      Inguinal, Hyperplasia                                         1 (2%)                                                          
      Inguinal, Hyperplasia, Lymphoid                  3 (6%)                                                                       
      Inguinal, Hyperplasia, Plasma Cell                                         1 (2%)                                             
      Mediastinal, Hyperplasia                                                   3 (6%)                                             
      Mediastinal, Hyperplasia, Lymphoid               2 (4%)                    1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
   Lymph Node, Mandibular                             (37)         (39)         (43)                                                
      Hyperplasia                                      1 (3%)                                                                       
      Hyperplasia, Lymphoid                            2 (5%)       1 (3%)       2 (5%)                                             
      Hyperplasia, Re Cell                                                       2 (5%)                                             
      Pigmentation, Hemosiderin                        1 (3%)       1 (3%)       3 (7%)                                             
   Lymph Node, Mesenteric                             (46)         (48)         (39)                                                
      Angiectasis                                                                1 (3%)                                             
      Hematopoietic Cell Proliferation                13 (28%)      7 (15%)      5 (13%)                                            
      Hemorrhage, Acute                               27 (59%)     25 (52%)     19 (49%)                                            
      Hemorrhage, Subacute                             5 (11%)      3 (6%)       1 (3%)                                             
      Hyperplasia, Lymphoid                            3 (7%)       4 (8%)       4 (10%)                                            
      Hyperplasia, Re Cell                                                       1 (3%)                                             
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
   Spleen                                             (50)         (49)         (50)                                                
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Fibrosis, Diffuse                                                          1 (2%)                                             
      Hematopoietic Cell Proliferation                18 (36%)     10 (20%)      8 (16%)                                            
      Hyperplasia, Lymphoid                            3 (6%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Re Cell                                                       1 (2%)                                             
      Necrosis, Focal, Subacute                        1 (2%)                                                                       
   Thymus                                             (45)         (38)         (32)                                                
      Cyst                                             1 (2%)                                                                       
      Depletion Lymphoid                               2 (4%)                    6 (19%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                    1 (3%)                                             
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (49)         (49)                                                
      Prepuce, Inflammation, Chronic Active            2 (4%)       1 (2%)       3 (6%)                                             
      Prepuce, Ulcer                                   1 (2%)       1 (2%)       3 (6%)                                             
      Subcutaneous Tissue, Abscess, Chronic                                      1 (2%)                                             
      Subcutaneous Tissue, Edema                       1 (2%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Inflammation, Diffuse,                                                                                   
           Subacute                                                              1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Granulomatous                               1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Subacute                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)                                                
      Fibrous Osteodystrophy                           3 (6%)                                                                       
      Osteoporosis                                                               1 (2%)                                             
      Sternum, Developmental Malformation                           2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                                                1 (2%)                                             
      Hemorrhage, Acute, Multifocal                                              1 (2%)                                             
      Infarct, Subacute                                                          1 (2%)                                             
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Mineralization, Multifocal                      31 (62%)     29 (58%)     30 (60%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (46)         (47)                                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Lung                                               (50)         (50)         (50)                                                
      Hemorrhage, Acute                                2 (4%)       1 (2%)       4 (8%)                                             
      Hemorrhage, Subacute                                          1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    4 (8%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Necrosis, Acute, Multifocal                                                2 (4%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)      13 (26%)      1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Multifocal                  8 (16%)     45 (90%)                                            
      Alveolus, Infiltration Cellular, Diffuse,                                                                                     
           Histiocyte                                               1 (2%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Focal,                                                                                       
          Histiocyte                                   1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                  6 (12%)      4 (8%)      20 (40%)                                            
      Artery, Thrombosis, Multifocal                                1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Bronchiole, Hyperplasia, Focal                                4 (8%)                                                          
      Bronchiole, Hyperplasia, Multifocal                           5 (10%)     40 (80%)                                            
      Bronchiole, Alveolus, Inflammation, Acute,                                                                                    
           Multifocal, Suppurative                                               1 (2%)                                             
      Mediastinum, Infiltration Cellular,                                                                                           
          Multifocal, Lymphocyte                       1 (2%)                    1 (2%)                                             
   Nose                                               (49)         (50)         (49)                                                
      Lumen, Exudate                                   1 (2%)       1 (2%)      29 (59%)                                            
      Mucosa, Inflammation, Acute                                                1 (2%)                                             
      Mucosa, Inflammation, Chronic Active             1 (2%)       2 (4%)       5 (10%)                                            
      Nasolacrimal Duct, Exudate                                                 1 (2%)                                             
      Nasolacrimal Duct, Hyperplasia                                             1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute                                     1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)       1 (2%)       1 (2%)                                             
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              3 (6%)       6 (12%)      5 (10%)                                            
      Respiratory Epithelium, Ulcer, Focal                                       1 (2%)                                             
   Trachea                                            (50)         (47)         (49)                                                
      Inflammation, Chronic Active                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Atrophy                                                       1 (100%)                                                        
   Lacrimal Gland                                                               (1)                                                 
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Abscess, Multiple                                                          1 (2%)                                             
      Hydronephrosis                                   1 (2%)       3 (6%)       2 (4%)                                             
      Infarct                                                       1 (2%)       3 (6%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Infiltration Cellular, Lymphocyte               18 (36%)     15 (30%)      7 (14%)                                            
      Mineralization, Multifocal                       2 (4%)                    1 (2%)                                             
      Nephropathy, Chronic                             3 (6%)       5 (10%)                                                         
      Bilateral, Hydronephrosis                        2 (4%)                                                                       
      Bilateral, Pelvis, Inflammation, Acute           2 (4%)                    1 (2%)                                             
      Capsule, Fibrosis, Focal                                                   1 (2%)                                             
      Cortex, Cyst                                                  1 (2%)                                                          
      Medulla, Necrosis, Acute, Focal                  1 (2%)                                                                       
      Pelvis, Inflammation, Acute                                   1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05072-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:51  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Proximal Convoluted Renal Tubule, Necrosis,                                                                                   
           Acute, Multifocal                           1 (2%)                                                                       
      Renal Tubule, Cytoplasmic Alteration,                                                                                         
          Multifocal                                                1 (2%)                                                          
      Renal Tubule, Hyperplasia, Atypical, Focal                    2 (4%)       1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                                           1 (2%)                                             
      Renal Tubule, Hyperplasia, Multifocal            1 (2%)       2 (4%)                                                          
   Urinary Bladder                                    (48)         (47)         (47)                                                
      Infiltration Cellular, Multifocal, Lymphocyte                 1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Diffuse                   1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse            2 (4%)                                                                       
      Ulcer, Multifocal                                1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia,                                                                                         
          Atypical, Diffuse                            1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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