National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2077

TR 386 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         TETRANITROMETHANE


NTP Experiment-Test: 05072-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53




       Facility:  Midwest Research Institute

       Chemical CAS #:  509-14-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      5            4           10                                                  
    Accidently Killed                                  2            1                                                               
    Moribund Sacrifice                                12           17           16                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           27           23                                                  
    Natural Death                                      1                                                                            
    Moribund Sacrifice                                              1            1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (49)                                                
   Gallbladder                                        (42)         (40)         (36)                                                
   Intestine Large, Cecum                             (47)         (44)         (45)                                                
   Intestine Large, Colon                             (49)         (47)         (46)                                                
   Intestine Large, Rectum                            (46)         (48)         (48)                                                
   Liver                                              (49)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen                                        2 (4%)                                             
      Hepatocellular Carcinoma                         4 (8%)       2 (4%)       3 (6%)                                             
      Hepatocellular Adenoma                           8 (16%)      1 (2%)       4 (8%)                                             
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
   Mesentery                                          (3)          (1)          (5)                                                 
   Pancreas                                           (49)         (50)         (50)                                                
   Salivary Glands                                    (48)         (50)         (50)                                                
   Stomach, Forestomach                               (48)         (50)         (49)                                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (47)         (49)         (49)                                                
   Tooth                                              (2)                       (2)                                                 
      Peridontal Tissue, Alveolar/Bronchiolar                                                                                       
          Carcinoma, Metastatic, Lung                                            1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (47)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (49)         (50)                                                
      Extra Adrenal Tissue, Alveolar/Bronchiolar                                                                                    
          Carcinoma, Metastatic, Lung                                            1 (2%)                                             
      Subcapsular, Adenoma                                                       1 (2%)                                             
   Adrenal Gland, Cortex                              (49)         (48)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (46)         (47)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (49)         (50)         (49)                                                
      Adenoma                                          3 (6%)                                                                       
   Parathyroid Gland                                  (39)         (38)         (40)                                                
      Adenoma                                          1 (3%)                                                                       
   Pituitary Gland                                    (49)         (49)         (48)                                                
      Pars Distalis, Adenoma                          18 (37%)     18 (37%)     13 (27%)                                            
      Pars Distalis, Adenoma, Multiple                              1 (2%)                                                          
      Pars Distalis, Adenoma, Two                                                1 (2%)                                             
      Pars Distalis, Carcinoma                         2 (4%)                                                                       
   Thyroid Gland                                      (48)         (50)         (50)                                                
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)       3 (6%)                                             
      Follicular Cell, Adenoma, Multiple                            1 (2%)                                                          
      Follicular Cell, Adenoma, Two                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (2)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (4%)                                             
      Luteoma                                                       1 (2%)                                                          
   Uterus                                             (49)         (50)         (50)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)       1 (2%)       1 (2%)                                             
      Polyp Stromal                                    1 (2%)       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (50)                                                
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (48)         (43)         (45)                                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
   Lymph Node, Mesenteric                             (41)         (36)         (37)                                                
   Spleen                                             (48)         (49)         (50)                                                
      Hemangiosarcoma                                                            4 (8%)                                             
   Thymus                                             (48)         (44)         (32)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (46)         (45)                                                
      Adenocarcinoma                                                1 (2%)       1 (2%)                                             
   Skin                                               (48)         (46)         (50)                                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma,                                                                                         
          Metastatic, Spleen                                                     1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Metastatic, Lung                                                      1 (2%)                                             
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (2)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (46)         (45)         (47)                                                
   Lung                                               (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)      12 (24%)     10 (20%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        7 (14%)     31 (62%)                                            
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       8 (16%)      5 (10%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple                      3 (6%)      40 (80%)                                            
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Osteosarcoma, Multiple, Metastatic, Bone         1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      2 (4%)                                             
   Nose                                               (49)         (50)         (50)                                                
      Mucosa, Alveolar/Bronchiolar Carcinoma,                                                                                       
          Metastatic, Lung                                                       1 (2%)                                             
   Trachea                                            (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (1)          (1)                                                 
      Adenoma                                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  3 (6%)                                             
      Bilateral, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (2%)                                             
   Ureter                                                                       (1)                                                 
   Urinary Bladder                                    (48)         (49)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                1 (2%)       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   3 (6%)       4 (8%)       3 (6%)                                             
      Lymphoma Malignant Mixed                         7 (14%)      5 (10%)      8 (16%)                                            
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       3 (6%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          44          49                                                   
     Total Primary Neoplasms                           63          79         137                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          36          45                                                   
     Total Benign Neoplasms                            38          49          65                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          24          47                                                   
     Total Malignant Neoplasms                         25          30          72                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1          11                                                   
     Total Metastatic Neoplasm                          2           3          31                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           19           17                                                  
    Natural Death                                      4            3           18                                                  
    Accidently Killed                                               2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           26           15                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (48)         (44)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (45)         (47)         (44)                                                
   Intestine Small, Jejunum                           (46)         (46)         (42)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       1 (2%)                                             
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  3 (6%)       3 (6%)       1 (2%)                                             
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatocellular Carcinoma                        10 (20%)      8 (16%)     11 (22%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)       3 (6%)                                                          
      Hepatocellular Adenoma                           7 (14%)     12 (24%)      2 (4%)                                             
      Hepatocellular Adenoma, Multiple                 3 (6%)       3 (6%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Mesentery                                                       (3)          (1)                                                 
   Pancreas                                           (50)         (49)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       2 (4%)                                             
      Duct, Adenocarcinoma                             1 (2%)                                                                       
   Salivary Glands                                    (50)         (48)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)      13 (26%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Subcapsular, Adenoma                             1 (2%)       2 (4%)                                                          
   Adrenal Gland, Cortex                              (49)         (47)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       3 (6%)                                             
   Adrenal Gland, Medulla                             (47)         (43)         (47)                                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Pituitary Gland                                    (48)         (48)         (48)                                                
      Pars Distalis, Adenoma                                                     1 (2%)                                             
   Thyroid Gland                                      (50)         (48)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Follicular Cell, Adenoma                         2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (7)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)     7 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Leiomyoma                                                     1 (2%)                                                          
   Prostate                                           (48)         (48)         (46)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (49)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
      Tunic, Alveolar/Bronchiolar Carcinoma,                                                                                        
          Metastatic, Lung                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (50)                                                
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (2%)                                             
      Lumbar, Alveolar/Bronchiolar Carcinoma,                                                                                       
          Metastatic, Lung                                                       1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      4 (8%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Pancreatic, Alveolar/Bronchiolar Carcinoma,                                                                                   
           Metastatic, Lung                                         1 (2%)                                                          
   Lymph Node, Mandibular                             (37)         (39)         (43)                                                
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      2 (5%)                                             
   Lymph Node, Mesenteric                             (46)         (48)         (39)                                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Pancreatic, Alveolar/Bronchiolar Carcinoma,                                                                                   
           Metastatic, Lung                                                      1 (3%)                                             
   Spleen                                             (50)         (49)         (50)                                                
      Hemangiosarcoma                                  2 (4%)       3 (6%)       1 (2%)                                             
   Thymus                                             (45)         (38)         (32)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  3 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (48)         (49)         (49)                                                
      Prepuce, Subcutaneous Tissue,                                                                                                 
          Alveolar/Bronchiolar Carcinoma,                                                                                           
          Metastatic, Lung                                          1 (2%)                                                          
      Subcutaneous Tissue, Alveolar/Bronchiolar                                                                                     
          Carcinoma, Metastatic, Lung                                            1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)                                                
      Rib, Alveolar/Bronchiolar Carcinoma,                                                                                          
          Metastatic, Lung                                                       1 (2%)                                             
   Skeletal Muscle                                                              (6)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  5 (83%)                                            
      Diaphragm, Hemangiosarcoma                                                 1 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (46)         (47)                                                
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     7 (14%)     16 (32%)     13 (26%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)      21 (42%)                                            
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      9 (18%)      6 (12%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple                      7 (14%)     40 (80%)                                            
      Hepatocellular Carcinoma, Metastatic, Liver      5 (10%)      3 (6%)       3 (6%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      7 (14%)                                            
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (1)          (1)                                                 
      Adenoma                                          2 (100%)     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)       8 (16%)                                            
   Urinary Bladder                                    (48)         (47)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                                2 (4%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05072-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         TETRANITROMETHANE                                     Date: 09/09/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:17:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      2 PPM                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          40          48                                                   
     Total Primary Neoplasms                           55          79         101                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          26          37                                                   
     Total Benign Neoplasms                            24          38          39                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          31          46                                                   
     Total Malignant Neoplasms                         31          41          62                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           4          18                                                   
     Total Metastatic Neoplasm                          6          13          65                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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