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https://ntp.niehs.nih.gov/go/3830

TR 387 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       DL AMPHETAMINE SULFATE


NTP Experiment-Test: 05029-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 11:07:09




       Facility:  Microbiological Associates

       Chemical CAS #:  60-13-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10            4            7                                                  
    Dead                                               7            4            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           42           37                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (49)         (49)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Submucosa, Hemorrhage                                         1 (2%)                                                          
   Intestine Large, Colon                             (50)         (50)         (49)                                                
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (49)         (50)                                                
      Ulcer, Chronic                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                 1 (2%)                                                                       
      Fatty Change                                    12 (24%)      4 (8%)       2 (4%)                                             
      Focal Cellular Change                           42 (84%)     42 (84%)     41 (82%)                                            
      Granuloma                                        1 (2%)                                                                       
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       1 (2%)       1 (2%)                                             
      Hepatodiaphragmatic Nodule                       5 (10%)      9 (18%)      9 (18%)                                            
      Hyperplasia, Focal                                            2 (4%)       1 (2%)                                             
      Hyperplasia, Multifocal                          1 (2%)       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
      Inflammation, Chronic, Multifocal               28 (56%)     25 (50%)     19 (38%)                                            
      Inflammation, Focal, Granulomatous                                         1 (2%)                                             
      Necrosis, Multifocal                                                       1 (2%)                                             
      Bile Duct, Hyperplasia, Focal                                              1 (2%)                                             
      Bile Duct, Hyperplasia, Multifocal              27 (54%)     36 (72%)     30 (60%)                                            
      Centrilobular, Necrosis, Acute                                1 (2%)                                                          
      Vein, Thrombosis                                                           1 (2%)                                             
   Mesentery                                          (6)          (1)          (1)                                                 
      Fat, Necrosis                                    6 (100%)     1 (100%)                                                        
   Pancreas                                           (49)         (49)         (49)                                                
      Metaplasia, Focal                                2 (4%)                                                                       
      Necrosis, Acute, Multifocal                                   1 (2%)                                                          
      Acinus, Atrophy, Diffuse                         2 (4%)       1 (2%)                                                          
      Acinus, Atrophy, Focal                          10 (20%)      5 (10%)      9 (18%)                                            
      Acinus, Atrophy, Multifocal                      6 (12%)      1 (2%)       9 (18%)                                            
      Acinus, Focal Cellular Change                    1 (2%)                                                                       
   Pharynx                                                         (1)                                                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Palate, Ulcer                                                 1 (100%)                                                        
   Salivary Glands                                    (48)         (49)         (49)                                                
      Atrophy, Diffuse                                              1 (2%)                                                          
   Stomach, Forestomach                               (49)         (49)         (50)                                                
      Erosion, Focal                                                             1 (2%)                                             
      Hyperplasia, Diffuse, Squamous                   2 (4%)                    1 (2%)                                             
      Hyperplasia, Focal, Squamous                     1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Ulcer, Multiple                                  1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (50)         (50)                                                
      Erosion, Focal                                   2 (4%)                                                                       
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Tongue                                             (1)                                                                           
      Abscess                                          1 (100%)                                                                     
   Tooth                                                           (1)          (1)                                                 
      Abscess                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (2)                                                              
      Aorta, Inflammation, Chronic, Focal                           1 (50%)                                                         
      Artery, Thrombosis                                            1 (50%)                                                         
   Heart                                              (49)         (50)         (50)                                                
      Cardiomyopathy, Multifocal                      30 (61%)     27 (54%)     28 (56%)                                            
      Inflammation, Acute, Multifocal                               1 (2%)                                                          
      Mineralization, Multifocal                       2 (4%)                                                                       
      Atrium, Thrombosis                                            1 (2%)       1 (2%)                                             
      Valve, Inflammation, Chronic Active                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (48)         (50)                                                
      Degeneration, Focal                              9 (18%)      6 (13%)      3 (6%)                                             
      Degeneration, Multifocal                         1 (2%)       3 (6%)                                                          
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematocyst                                       1 (2%)       4 (8%)       4 (8%)                                             
      Hematocyst, Focal                                             1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Hyperplasia, Focal                               6 (12%)      7 (15%)      6 (12%)                                            
      Hyperplasia, Multifocal                          5 (10%)      3 (6%)       1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (47)         (49)                                                
      Hyperplasia, Focal                               2 (4%)       8 (17%)      3 (6%)                                             
      Hyperplasia, Multifocal                          4 (8%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (50)         (48)         (50)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (48)         (50)                                                
      Pars Distalis, Angiectasis, Focal                2 (4%)       3 (6%)       1 (2%)                                             
      Pars Distalis, Cyst                             11 (22%)      4 (8%)       8 (16%)                                            
      Pars Distalis, Fibrosis                                                    1 (2%)                                             
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal                5 (10%)      1 (2%)       4 (8%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Hyperplasia, Diffuse                     1 (2%)                                                                       
      C-Cell, Hyperplasia, Focal                       4 (8%)       4 (8%)       3 (6%)                                             
      C-Cell, Hyperplasia, Multifocal                  7 (14%)                   1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (39)         (37)         (39)                                                
      Ectasia                                          1 (3%)                                                                       
      Hyperplasia                                      1 (3%)                                                                       
      Hyperplasia, Focal                               3 (8%)       2 (5%)                                                          
      Inflammation, Acute, Focal                       1 (3%)                                                                       
      Inflammation, Chronic, Focal                     2 (5%)                    1 (3%)                                             
      Inflammation, Chronic, Multifocal                2 (5%)       2 (5%)                                                          
      Inflammation, Chronic Active, Multifocal                      3 (8%)                                                          
   Ovary                                              (50)         (50)         (50)                                                
      Cyst                                             4 (8%)       4 (8%)       1 (2%)                                             
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)                                                
      Abscess                                                       1 (2%)                                                          
      Amyloid Deposition                                            1 (2%)                                                          
      Dilatation                                       3 (6%)                    4 (8%)                                             
      Cervix, Cyst                                     3 (6%)       1 (2%)                                                          
      Cervix, Dilatation                                            2 (4%)                                                          
      Cervix, Inflammation, Acute                                   1 (2%)                                                          
      Cervix, Inflammation, Chronic                    1 (2%)                                                                       
      Cervix, Inflammation, Chronic Active             3 (6%)                                                                       
      Cervix, Metaplasia, Squamous                     3 (6%)                                                                       
      Endometrium, Cyst                                                          4 (8%)                                             
      Endometrium, Cyst, Multiple                      2 (4%)       4 (8%)      11 (22%)                                            
      Endometrium, Hyperplasia                         1 (2%)                                                                       
      Endometrium, Inflammation, Focal, Subacute                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Lumen, Hemorrhage                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Hyperplasia                                      8 (16%)      2 (4%)       1 (2%)                                             
      Myelofibrosis, Focal                                                       1 (2%)                                             
      Myelofibrosis, Multifocal                        1 (2%)       2 (4%)      10 (20%)                                            
   Lymph Node                                         (50)         (50)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Mediastinal, Pigmentation                                                  1 (2%)                                             
   Lymph Node, Mandibular                             (47)         (49)         (48)                                                
      Congestion                                                                 1 (2%)                                             
      Degeneration, Cystic, Focal                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Pigmentation                                                  1 (2%)                                                          
   Lymph Node, Mesenteric                             (46)         (49)         (49)                                                
      Congestion                                                    1 (2%)       4 (8%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
      Infiltration Cellular, Histiocyte               10 (22%)                   3 (6%)                                             
   Spleen                                             (50)         (50)         (49)                                                
      Congestion                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 3 (6%)       2 (4%)                                                          
      Infarct                                          3 (6%)                    2 (4%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Lymphoid Follicle, Atrophy                       2 (4%)       1 (2%)                                                          
      Lymphoid Follicle, Hyperplasia, Focal            3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (47)                                                
      Acinus, Hyperplasia, Focal                       2 (4%)       1 (2%)       1 (2%)                                             
      Duct, Ectasia                                   27 (56%)     20 (41%)      5 (11%)                                            
   Skin                                               (50)         (50)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                                               2 (4%)                                             
      Ulcer                                                         1 (2%)                                                          
      Subcutaneous Tissue, Hemorrhage                  1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Focal                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Hyperostosis                                     4 (8%)       4 (8%)       6 (12%)                                            
      Osteomalacia                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cerebrum, Hydrocephalus                          1 (2%)                    1 (2%)                                             
      Cerebrum, Infiltration Cellular, Focal,                                                                                       
          Lymphocyte                                   1 (2%)                                                                       
      Cerebrum, Necrosis, Focal                                     1 (2%)                                                          
      Hypothalamus, Compression                        6 (12%)      7 (14%)      2 (4%)                                             
   Spinal Cord                                        (50)         (49)         (49)                                                
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)                                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Infiltration Cellular, Multifocal, Histiocyte   19 (38%)     22 (44%)     20 (40%)                                            
      Pigmentation, Multifocal                                      1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       3 (6%)                                                          
      Interstitium, Inflammation, Chronic, Diffuse                  1 (2%)                                                          
      Interstitium, Inflammation, Chronic, Focal       1 (2%)                                                                       
      Peribronchial, Hyperplasia, Lymphoid             1 (2%)                                                                       
      Pleura, Fibrosis, Focal                                       1 (2%)                                                          
      Pleura, Inflammation, Chronic, Focal             1 (2%)                                                                       
      Pleura, Inflammation, Multifocal,                                                                                             
          Proliferative                                1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Fungus                                           2 (4%)       3 (6%)       1 (2%)                                             
      Mucosa, Cytoplasmic Alteration, Multifocal      37 (74%)     39 (78%)     34 (68%)                                            
      Mucosa, Inflammation, Acute, Multifocal          2 (4%)                    2 (4%)                                             
      Mucosa, Inflammation, Chronic, Focal                          1 (2%)                                                          
      Mucosa, Inflammation, Chronic, Multifocal        1 (2%)                                                                       
      Mucosa, Inflammation, Chronic Active, Focal                                1 (2%)                                             
      Mucosa, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   1 (2%)       4 (8%)                                                          
      Mucosa, Inflammation, Multifocal, Subacute       2 (4%)       3 (6%)                                                          
      Mucosa, Metaplasia, Focal, Squamous              1 (2%)       2 (4%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         2 (4%)       4 (8%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       4 (8%)       1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)                                                
      Lens, Cataract                                  12 (24%)      7 (14%)     36 (72%)                                            
      Retina, Atrophy                                 25 (50%)     17 (34%)     42 (84%)                                            
      Sclera, Metaplasia, Focal, Osseous              11 (22%)     10 (20%)     12 (24%)                                            
      Sclera, Metaplasia, Multifocal, Osseous          8 (16%)     15 (30%)      5 (10%)                                            
   Harderian Gland                                                 (2)          (2)                                                 
      Infiltration Cellular, Multifocal, Lymphocyte                              1 (50%)                                            
      Inflammation, Acute                                           1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Bacterium                                                     1 (2%)       1 (2%)                                             
      Cyst                                                          1 (2%)       1 (2%)                                             
      Inflammation, Acute, Multifocal                               1 (2%)       1 (2%)                                             
      Nephropathy, Chronic, Multifocal                32 (64%)     18 (36%)                                                         
      Papilla, Necrosis                                1 (2%)                                                                       
      Pelvis, Mineralization, Multifocal               1 (2%)       2 (4%)                                                          
      Renal Tubule, Pigmentation                       2 (4%)       1 (2%)                                                          
   Urinary Bladder                                    (50)         (48)         (50)                                                
      Calculus Gross Observation                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               8           11            9                                                  
    Moribund                                          12            8            8                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (50)                                                
      Inflammation, Subacute                           1 (2%)                                                                       
   Intestine Small, Duodenum                          (49)         (50)         (48)                                                
      Ectopic Tissue                                                             1 (2%)                                             
   Intestine Small, Ileum                             (49)         (49)         (48)                                                
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (49)         (46)                                                
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                                           2 (4%)                                             
      Degeneration, Cystic, Focal                      4 (8%)       6 (12%)      3 (6%)                                             
      Degeneration, Cystic, Multifocal                 1 (2%)       2 (4%)                                                          
      Fatty Change                                     5 (10%)      9 (18%)      6 (12%)                                            
      Focal Cellular Change                           29 (58%)     23 (46%)     32 (64%)                                            
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)                                                                       
      Hepatodiaphragmatic Nodule                       6 (12%)      4 (8%)       2 (4%)                                             
      Hyperplasia, Focal                               3 (6%)       1 (2%)                                                          
      Hyperplasia, Multifocal                                       1 (2%)       2 (4%)                                             
      Inflammation, Chronic, Multifocal                7 (14%)      2 (4%)       2 (4%)                                             
      Necrosis, Acute, Multifocal                                   1 (2%)       1 (2%)                                             
      Bile Duct, Hyperplasia, Multifocal              46 (92%)     47 (94%)     45 (90%)                                            
      Centrilobular, Congestion, Chronic                                         1 (2%)                                             
      Centrilobular, Necrosis, Acute                   1 (2%)       2 (4%)                                                          
      Vein, Thrombosis                                              1 (2%)                                                          
   Mesentery                                          (6)          (5)          (5)                                                 
      Inflammation, Chronic, Multifocal                1 (17%)                                                                      
      Fat, Necrosis                                    4 (67%)      2 (40%)      4 (80%)                                            
   Pancreas                                           (49)         (49)         (49)                                                
      Acinus, Atrophy, Diffuse                         1 (2%)                    2 (4%)                                             
      Acinus, Atrophy, Focal                          14 (29%)     11 (22%)      7 (14%)                                            
      Acinus, Atrophy, Multifocal                     11 (22%)      8 (16%)      8 (16%)                                            
      Acinus, Focal Cellular Change                    1 (2%)       1 (2%)                                                          
      Acinus, Hyperplasia, Focal                       1 (2%)       2 (4%)                                                          
      Artery, Inflammation, Chronic                    1 (2%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (50)         (48)         (50)                                                
      Hemorrhage, Focal                                1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Stomach, Forestomach                               (48)         (50)         (50)                                                
      Erosion                                                                    1 (2%)                                             
      Hyperplasia, Multifocal, Squamous                1 (2%)                                                                       
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse                                      1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      Ulcer                                            1 (2%)       2 (4%)       2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Erosion, Focal                                                1 (2%)       2 (4%)                                             
      Erosion, Multifocal                                           1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (2)                                                              
      Aorta, Arteriosclerosis                                       2 (100%)                                                        
   Heart                                              (50)         (49)         (50)                                                
      Cardiomyopathy, Multifocal                      40 (80%)     40 (82%)     40 (80%)                                            
      Mineralization, Multifocal                                    1 (2%)                                                          
      Atrium, Thrombosis                               1 (2%)       3 (6%)       4 (8%)                                             
      Coronary Artery, Inflammation, Chronic                                     2 (4%)                                             
      Valve, Inflammation, Chronic                                  2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (48)         (50)                                                
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Degeneration, Focal                              6 (12%)      6 (13%)      3 (6%)                                             
      Degeneration, Multifocal                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)                    5 (10%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Focal                               4 (8%)       8 (17%)      3 (6%)                                             
      Hyperplasia, Multifocal                          2 (4%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (44)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Focal                               5 (10%)      2 (5%)       2 (4%)                                             
      Hyperplasia, Multifocal                          3 (6%)       2 (5%)                                                          
   Islets, Pancreatic                                 (50)         (47)         (50)                                                
      Hyperplasia, Focal                               1 (2%)                    2 (4%)                                             
   Pituitary Gland                                    (49)         (48)         (49)                                                
      Hemorrhage                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Abscess                           1 (2%)                                                                       
      Pars Distalis, Angiectasis                                    2 (4%)       1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       3 (6%)                                             
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                7 (14%)      6 (13%)      7 (14%)                                            
      Pars Distalis, Hyperplasia, Multifocal                        1 (2%)       2 (4%)                                             
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Hyperplasia, Focal                       3 (6%)       6 (12%)      5 (10%)                                            
      C-Cell, Hyperplasia, Multifocal                  3 (6%)       3 (6%)                                                          
      Follicle, Cyst                                   1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Granuloma Sperm                                                            1 (2%)                                             
   Preputial Gland                                    (48)         (47)         (49)                                                
      Abscess                                          1 (2%)                    2 (4%)                                             
      Hyperplasia, Focal                                            2 (4%)       1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Acute, Multifocal                  1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Diffuse                                3 (6%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     3 (6%)       1 (2%)       5 (10%)                                            
      Inflammation, Chronic, Multifocal               15 (31%)     21 (45%)     17 (35%)                                            
      Inflammation, Chronic Active, Focal              2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active, Multifocal         1 (2%)       6 (13%)      5 (10%)                                            
      Inflammation, Multifocal, Subacute               1 (2%)                                                                       
   Prostate                                           (49)         (49)         (50)                                                
      Hyperplasia, Focal                               7 (14%)      3 (6%)       3 (6%)                                             
      Hyperplasia, Multifocal                                                    2 (4%)                                             
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Acute, Multifocal                                            1 (2%)                                             
      Inflammation, Chronic, Focal                     4 (8%)       2 (4%)                                                          
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse                         1 (2%)                                                          
      Inflammation, Chronic Active, Multifocal         1 (2%)                    1 (2%)                                             
      Inflammation, Focal, Subacute                                 1 (2%)                                                          
      Epithelium, Hyperplasia, Multifocal                           1 (2%)                                                          
   Seminal Vesicle                                    (49)         (49)         (49)                                                
      Atrophy, Diffuse                                27 (55%)     30 (61%)     36 (73%)                                            
      Dilatation                                       1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Atrophy, Diffuse                                 4 (8%)       5 (10%)      1 (2%)                                             
      Atrophy, Focal                                   1 (2%)                    1 (2%)                                             
      Granuloma Sperm                                  1 (2%)                                                                       
      Interstitial Cell, Hyperplasia, Multifocal       5 (10%)      8 (16%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia                                      3 (6%)       6 (12%)      6 (12%)                                            
      Infiltration Cellular, Focal, Histiocyte         1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)                                                
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
   Lymph Node, Mandibular                             (48)         (45)         (49)                                                
      Congestion                                                    1 (2%)       1 (2%)                                             
      Degeneration, Cystic                             3 (6%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)       3 (6%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (49)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)       1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                3 (6%)       3 (6%)       5 (10%)                                            
   Spleen                                             (50)         (49)         (50)                                                
      Atrophy, Focal                                   1 (2%)                                                                       
      Congestion                                                    1 (2%)                                                          
      Fibrosis, Diffuse                                1 (2%)                                                                       
      Fibrosis, Focal                                  3 (6%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       3 (6%)       1 (2%)                                             
      Artery, Thrombosis                                            1 (2%)                                                          
      Lymphoid Follicle, Atrophy                       1 (2%)                    4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (37)         (44)         (48)                                                
      Inflammation, Chronic                            1 (3%)                                                                       
      Acinus, Hyperplasia, Diffuse                                  1 (2%)                                                          
      Acinus, Hyperplasia, Focal                       1 (3%)       1 (2%)                                                          
      Duct, Ectasia                                    8 (22%)      8 (18%)      4 (8%)                                             
   Skin                                               (50)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic Active, Focal                           1 (2%)                                                          
      Hair Follicle, Atrophy                                                     1 (2%)                                             
      Subcutaneous Tissue, Fibrosis, Focal             1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Hyperostosis                                     2 (4%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Hydrocephalus                                    1 (2%)                                                                       
      Cerebellum, Necrosis, Focal                      1 (2%)                                                                       
      Cerebrum, Necrosis, Focal                                                  1 (2%)                                             
      Hypothalamus, Compression                        3 (6%)       4 (8%)       1 (2%)                                             
   Spinal Cord                                        (50)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Abscess, Multifocal                                                        1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Foreign Body                                     2 (4%)                    1 (2%)                                             
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Focal, Histiocyte                      1 (2%)                                                          
      Infiltration Cellular, Multifocal, Histiocyte    4 (8%)       9 (18%)      6 (12%)                                            
      Inflammation, Acute, Multifocal                  1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous, Multifocal          1 (2%)                                                                       
      Leukocytosis                                                  1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          3 (6%)                    4 (8%)                                             
      Alveolar Epithelium, Hyperplasia, Multifocal                  2 (4%)                                                          
      Interstitium, Inflammation, Chronic,                                                                                          
          Multifocal                                   2 (4%)       2 (4%)                                                          
      Peribronchiolar, Hyperplasia, Lymphoid           1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
      Foreign Body                                     2 (4%)                    3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Fungus                                           7 (14%)      9 (18%)      4 (8%)                                             
      Inflammation, Chronic Active, Multifocal                      2 (4%)                                                          
      Metaplasia, Focal, Squamous                                                1 (2%)                                             
      Mucosa, Cytoplasmic Alteration, Multifocal       2 (4%)                                                                       
      Mucosa, Foreign Body, Focal                      1 (2%)                                                                       
      Mucosa, Inflammation, Acute, Focal               1 (2%)       1 (2%)                                                          
      Mucosa, Inflammation, Acute, Multifocal          2 (4%)       2 (4%)                                                          
      Mucosa, Inflammation, Chronic, Focal                          2 (4%)                                                          
      Mucosa, Inflammation, Chronic, Multifocal        2 (4%)       2 (4%)       1 (2%)                                             
      Mucosa, Inflammation, Chronic Active,                                                                                         
          Multifocal                                   5 (10%)      8 (16%)      5 (10%)                                            
      Mucosa, Inflammation, Focal, Subacute            1 (2%)                                                                       
      Mucosa, Inflammation, Multifocal, Subacute       2 (4%)                    2 (4%)                                             
      Mucosa, Metaplasia, Focal, Squamous                           1 (2%)                                                          
      Mucosa, Metaplasia, Multifocal, Squamous         1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         7 (14%)     10 (20%)      6 (12%)                                            
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       2 (4%)       2 (4%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Subacute                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (48)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Anterior Chamber, Hemorrhage                                  1 (2%)                                                          
      Cornea, Inflammation, Chronic Active                          1 (2%)                                                          
      Lens, Cataract                                   6 (12%)     10 (20%)      6 (13%)                                            
      Retina, Atrophy                                 14 (28%)      9 (18%)      3 (6%)                                             
      Sclera, Metaplasia, Focal, Osseous              21 (42%)     13 (26%)     14 (29%)                                            
      Sclera, Metaplasia, Multifocal, Osseous         22 (44%)     30 (60%)     26 (54%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Nephropathy, Chronic, Multifocal                47 (94%)     46 (92%)     45 (90%)                                            
      Papilla, Necrosis                                             1 (2%)                                                          
      Pelvis, Dilatation                                            2 (4%)                                                          
      Renal Tubule, Mineralization, Multifocal                      1 (2%)                                                          
      Renal Tubule, Pigmentation                       2 (4%)       3 (6%)       4 (8%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Calculus Micro Observation Only                               1 (2%)                                                          
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Hemorrhagic                                     1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05029-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:09  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Subacute                                        1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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