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TR 388 Mouse Pathology Tables

NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97
Route: DOSED FEED                                                                                                 Time: 14:20:40




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-45-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|             
                                           | 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                         X|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +|             
      Leiomyosarcoma                       |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                    X                     |             
      Hemangiosarcoma, Multiple            | X                                                                        |             
      Hepatocellular Carcinoma             | X                                                                        |             
      Hepatocellular Adenoma               |                         X        X                                       |             
      Lymphoma Malignant Lymphocytic       |                                                                X     X   |             
      Lymphoma Malignant Mixed             |       X                                                                 X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Hemangiosarcoma                      |                                                                          |             
      Lipoma                               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|             
                                           | 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                      X           X                                   X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X     X   |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Undifferentiated Cell  |                                                                          |             
          Type                             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hemangiosarcoma             |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                X         |             
      Femoral, Lymphoma Malignant Mixed    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|             
                                           | 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                X     X   |             
      Mandibular, Lymphoma Malignant Mixed |       X        X  X              X        X                 X           X|             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +        +  M              +                                   +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |       X        X                 X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                +                                               +         |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X     X   |             
      Lymphoma Malignant Mixed             |       X        X                 X        X                 X           X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  M  A  A  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X                       X                             X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +  +  M  M  M  M  +  +  +|             
      Adenocarcinoma                       |                                                                      X   |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                    X                     |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                   X                                         X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteosarcoma                |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|             
                                           | 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Alveolar/Bronchiolar Carcinoma       | X                                      X     X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                X     X   |             
      Lymphoma Malignant Mixed             |       X        X                                            X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinum, Lymphoma Malignant Mixed|                   X                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +                                          |             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Renal Tubule, Adenoma, Multiple      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                X     X   |             
      Lymphoma Malignant Mixed             |       X        X  X              X        X                 X           X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  M  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                   X      |          2 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                  X        X                              |          4 |
      Lymphoma Malignant Mixed             |    X                 X        X     X                                    |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +  +                                +  +               |   6        |
      Hemangiosarcoma                      |          X                                                               |          1 |
      Lipoma                               |                   X                                                      |          1 |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                      X                                                   |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant Mixed             |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Squamous Cell Papilloma              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Adenoma               |       X        X  X           X        X        X              X         |         10 |
      Pars Distalis, Carcinoma             |                            X                                             |          1 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cystadenoma                          |                                                                   X      |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                           X                              |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Undifferentiated Cell  |                                                                          |            |
          Type                             |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Femoral, Hemangiosarcoma             |                                                                      X   |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                       X                  |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                           X                              |          2 |
      Femoral, Lymphoma Malignant Mixed    |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                       X                  |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                  X        X                             X|          5 |
      Mandibular, Lymphoma Malignant Mixed |    X              X  X     X  X     X  X                                 |         14 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                          X               |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                       X                  |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                  X                                      X|          2 |
      Mediastinal, Lymphoma Malignant Mixed|    X                 X     X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +     +           +  +     +  +              +              +|  14        |
      Lymphoma Malignant Lymphocytic       |                                  X        X                             X|          3 |
      Lymphoma Malignant Mixed             |                   X           X        X                                 |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   2        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                      X   |          1 |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X        X                             X|          5 |
      Lymphoma Malignant Mixed             |    X                 X     X  X     X  X                                 |         12 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +|  39        |
      Lymphoma Malignant Lymphocytic       |                                  X                                      X|          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                               X                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  35        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                      X   |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Osteosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                            X                                             |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                               X                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Lymphoma Malignant Lymphocytic       |                                  X                                      X|          4 |
      Lymphoma Malignant Mixed             |    X                 X              X                                    |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Mediastinum, Lymphoma Malignant Mixed|                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   3        |
      Adenoma                              |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                  X        X                             X|          4 |
      Lymphoma Malignant Mixed             |    X                 X        X     X                                    |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
      Renal Tubule, Adenoma, Multiple      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X        X                             X|          5 |
      Lymphoma Malignant Mixed             |    X              X  X     X  X     X  X                                 |         14 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                          X               |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|             
                                           | 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          A           A     M  +              A        +     +     +      |             
      Lymphoma Malignant Mixed, Moderate   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          A     +     +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          A           A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          A           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          A           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          A           A     +  +              +     +  +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          A           A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          A           A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          A           A     +  +              +     +  +     +     +      |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                    X                     |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                            X                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Islets,       |                                                                          |             
          Pancreatic                       |                                                                          |             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                 X                        |             
      Hepatocellular Carcinoma             |                            X        X  X     X                           |             
      Hepatocellular Adenoma               |                                        X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                  X                    X           X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          A           A     +  +              +        +     +     +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          A           +     +  +              +        +     +     +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  A           A     +  +     +        +        +     +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  A           A     +  +     +        +        +     +     +      |             
      Squamous Cell Papilloma              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          A           A     +  +              +        +     +     +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|             
                                           | 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +           +     +  +              +        +     +     +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +           +     +  +              +        +     +     +      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          A     +     A     +  +              +        +     +     +      |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          M           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                      X              X                 X        X         |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  A           +     +  +  +           +  +     +  +  +  +  +      |             
      Hemangioma                           |                                                                          |             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  A     +  +  +  +  +  +  +     +     +  +     +  +  +  +  +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +           +     +  +              +        +     +     +      |             
      Femoral, Lymphoma Malignant Mixed    |                                                       X                  |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Undifferentiated Cell Type       |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          A           +  +  +  +           +  +     +  +     +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|             
                                           | 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                           X                              |             
      Lumbar, Lymphoma Malignant Mixed     |                                           X                              |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                    X                     |             
      Mandibular, Lymphoma Malignant Mixed |                                           X           X                  |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                            X                                             |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                           X                       X      |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                            X                                             |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                           X                              |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                            X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                            +              +           +           +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X           X           X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +     +  +  +        +  +     +  +     +     +      |             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                  X        X           X           X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  |          A           +     M  +              M        +     I     M      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M           +     +  +              +        +     +     +      |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |          +           +     +  +              +        +     +     +      |             
      Subcutaneous Tissue, Fibrosarcoma    |                      X                                                   |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|             
                                           | 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +           +     +  +              +        +     +     +      |             
      Cranium, Osteosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +           +     +  +              +        +     +     +      |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                          X                                    |             
      Alveolar/Bronchiolar Carcinoma       |       X                                   X                              |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          A           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |          A           +     +  +              +        +     +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                         +      |             
      Adenocarcinoma                       |                         X                                                |             
      Adenoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          A           +     +  +              +        +     +     +      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          A           +     +  +              +        +     +     +      |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                  X        X           X           X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |       X                    X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                               +                 A  +  +  A        A      |   7        |
      Lymphoma Malignant Mixed, Moderate   |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                 +  M  +  +        +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                 +  +  +  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                 +  M  +  +        +      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                 +  +  +  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                 +  +  +  +        +      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                 +  M  +  +        +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                 +  +  +  +        +      |  12        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                 X  X                     |          2 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Islets,       |                                                                          |            |
          Pancreatic                       |                                        X                                 |          1 |
      Hemangioma                           |                                           X                              |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                         X|          5 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                           X     X                 X      |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +           +      |   2        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                 +  +  +  +        +      |  11        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                                            +  +  +  +        +      |  13        |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                     +     +     +  +  +  +        +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                     +     +     +  +  +  +        +      |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                 +  +  +  +        +      |  11        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                 +  +  +  +        +      |  13        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                 +  +  +  +        +      |  13        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                        +        +  +  +  +        +      |  13        |
      Carcinoma                            |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                 +  +  +  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |       X        X                    X     X     X           X           X|         11 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Histiocytic                      |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +        +  +     +  +                       +  +  +  +     +  +  +  +|  26        |
      Hemangioma                           |             X                                                            |          1 |
      Luteoma                              |                         X                                                |          1 |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +        +     +     +  +  +  +  +        +     +|  33        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                 +  +  +  +        +      |  13        |
      Femoral, Lymphoma Malignant Mixed    |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                     +           +  +  +  +  +     +  +   |  18        |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                             X            |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                       X                  |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                 X           X     X  X   |          6 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                       X                  |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                   X  X   |          4 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                             X            |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                 X           X     X  X   |          5 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                     +           +  +  +           +  +   |  10        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                 X  X              X  X   |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +                                   +  +  +  +  +     +  +   |  23        |
      Hemangiosarcoma                      |                                                          X               |          1 |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          2 |
      Lymphoma Malignant Mixed             |                                                 X  X        X     X  X   |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                 +  +  +  M        +      |   7        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                 +  +  +  +  +     +      |  13        |
      Fibroadenoma                         |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                 +  +  +  +        +      |  13        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                          X               |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                 +  +  +  +        +      |  13        |
      Cranium, Osteosarcoma                |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                 +  +  +  +        +      |  13        |
      Osteosarcoma, Metastatic, Bone       |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                      X                                                   |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                               X                                          |          2 |
      Osteosarcoma, Metastatic, Bone       |                                                    X                     |          1 |
      Mediastinum, Lymphoma Malignant Mixed|                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                 +  +  +  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                 +  +  +  +        +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                               X                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|     A      |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                 +  +  +  +        +      |  12        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                 +  +  +  +        +      |  12        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |          X                                                               |          2 |
      Lymphoma Malignant Mixed             |                               X           X     X  X        X     X  X   |         11 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +           +           +        +                              |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +           +           +        +                 +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +           +           +        +                 +     +      |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             | X     X                                                                  |             
      Hepatocellular Adenoma               |                X                                                        X|             
      Histiocytic Sarcoma, Single          |    X                                                                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X        X                              |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +           +           +        +                       +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +           +           +        +                       +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +           +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +           +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +           +           +        M                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                            X           X                    X  X  X      |             
      Pars Distalis, Carcinoma             |          X                                                               |             
      Pars Intermedia, Adenoma             |                X           X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +     +  +     +  +  +  +  +  +           +  +  +|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                  X        X                              |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                         X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +        +  +     +     +  +     +              +               |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +           +           +        +                              |             
      Femoral, Histiocytic Sarcoma, Single |    X                                                                     |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +        +        +  +        +              +  +     +     +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                  X        X                              |             
      Lumbar, Lymphoma Malignant Mixed     |                               X                                          |             
      Mandibular, Histiocytic Sarcoma,     |                                                                          |             
           Single                          |    X                                                                     |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                  X        X                              |             
      Mandibular, Lymphoma Malignant Mixed |                               X                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                  X        X                              |             
      Mediastinal, Lymphoma Malignant Mixed|                               X                                         X|             
      Pancreatic, Lymphoma Malignant Mixed |                                                                   X      |             
      Popliteal, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                           X                              |             
      Renal, Lymphoma Malignant Lymphocytic|                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +        +                 +  +        +              +  +            |             
      Histiocytic Sarcoma, Single          |    X                                                                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X        X                              |             
      Lymphoma Malignant Mixed             |                               X                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +           +     +  +  +        +              +        +  +   |             
      Histiocytic Sarcoma, Single          |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X        X                              |             
      Lymphoma Malignant Mixed             |                               X                          X        X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M           +           M        +                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +           +        +  +        +                              |             
      Adenocarcinoma                       |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +           +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Harderian Gland                  |                      X                                                   |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Histiocytic Sarcoma, Single          |    X                                                                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X        X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +           +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
      Adenocarcinoma                       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +           +           +        +                              |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X        X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +           +           +        +                              |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                  X        X                              |             
      Lymphoma Malignant Mixed             |                               X                          X        X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7|                                                              |            |
                             DAY ON TEST   | 5| 5| 1| 5|                                                              |            |
                                           | 0| 0| 2| 0|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    100 PPM                                | 3| 3| 3| 3|                                                              |     L      |
      1-1                                  | 1| 2| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +                                                                  |   8        |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                                                                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                                                                  |  10        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  28        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Histiocytic Sarcoma, Single          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                                                                  |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                                                                  |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                                                                  |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                                                                  |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +                                                                  |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  28        |
      Pars Distalis, Adenoma               | X                                                                        |          6 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7|                                                              |            |
                             DAY ON TEST   | 5| 5| 1| 5|                                                              |            |
                                           | 0| 0| 2| 0|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    100 PPM                                | 3| 3| 3| 3|                                                              |     L      |
      1-1                                  | 1| 2| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  29        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +                                                                  |  20        |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          2 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +                                                                  |  13        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                                                                  |   8        |
      Femoral, Histiocytic Sarcoma, Single |                                                                          |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  15        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mandibular, Histiocytic Sarcoma,     |                                                                          |            |
           Single                          |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |       X                                                                  |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7|                                                              |            |
                             DAY ON TEST   | 5| 5| 1| 5|                                                              |            |
                                           | 0| 0| 2| 0|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    100 PPM                                | 3| 3| 3| 3|                                                              |     L      |
      1-1                                  | 1| 2| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Popliteal, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                                                  |   8        |
      Histiocytic Sarcoma, Single          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +                                                                  |  13        |
      Histiocytic Sarcoma, Single          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M                                                                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M                                                                  |   8        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                                                                  |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                                                                  |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  29        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Harderian Gland                  |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Histiocytic Sarcoma, Single          |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                                                                  |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7|                                                              |            |
                             DAY ON TEST   | 5| 5| 1| 5|                                                              |            |
                                           | 0| 0| 2| 0|                                                              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0|                                                              |     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1|                                                              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |     A      |
    100 PPM                                | 3| 3| 3| 3|                                                              |     L      |
      1-1                                  | 1| 2| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenocarcinoma                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                                                                  |   8        |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                                                                  |   8        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +                                                               |  29        |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +                          +  +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +                          +  +     +                        |             
      Leiomyosarcoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +        +                          +  +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +                          +  +     +                        |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |          X        X                                               X      |             
      Hepatocellular Carcinoma             |                   X                 X        X     X  X                  |             
      Hepatocellular Carcinoma, Multiple   | X              X              X                             X     X  X   |             
      Hepatocellular Adenoma               | X  X     X        X  X     X     X     X  X              X               |             
      Hepatocellular Adenoma, Multiple     |                X              X     X        X     X  X     X  X         |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                           X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +                             +     +                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +        +  +        +                 +     +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +  +        +                 +     +                        |             
      Squamous Cell Papilloma              |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X     X     X     X     X     X  X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Adenoma, Multiple   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +  +  +                          +     +     +  +               |             
      Cystadenoma, Papillary               |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +     +  +     +     +              +  +  +                       +|             
      Leiomyosarcoma                       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +                             +     +                        |             
      Femoral, Histiocytic Sarcoma, Single |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
      Femoral, Lymphoma Malignant Mixed    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +  +        +           +  +  +     +     +        +        +|             
      Axillary, Lymphoma Malignant Mixed   |                                                                X         |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                X         |             
      Mandibular, Histiocytic Sarcoma,     |                                                                          |             
           Single                          |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |    X           X        X                                                |             
      Mandibular, Sarcoma, Metastatic,     |                                                                          |             
           Uncertain Primary Site          |                                     X                                    |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|    X           X                                                         |             
      Pancreatic, Leiomyosarcoma,          |                                                                          |             
          Metastatic, Intestine Large      |                                        X                                 |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +           +                       +              +        +        +|             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |    X           X                       X                       X        X|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +  +  +              +  +  +  +  +  +  +     +  +      |             
      Hemangiosarcoma                      |                                                          X        X      |             
      Histiocytic Sarcoma, Single          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |    X     X     X        X              X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +                             +     M                        |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |    X     X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +                             +     +                        |             
      Adenocarcinoma                       |                                           X                              |             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +                             +     +                        |             
      Histiocytic Sarcoma, Single          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X              X                    X        X   |             
      Alveolar/Bronchiolar Carcinoma       |                            X                                             |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                               X         |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
      Bilateral, Adenoma                   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +           +                 +     +                        |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X     X     X        X              X                       X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5|            |
                                           | 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +        +                                                        +   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +        +                                                        +   |   9        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +        +                                                        +   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +        +                                                        A   |   8        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                      X                                                   |          4 |
      Hepatocellular Carcinoma             | X  X  X  X           X  X                          X           X     X   |         14 |
      Hepatocellular Carcinoma, Multiple   |                               X  X  X        X  X     X  X  X           X|         15 |
      Hepatocellular Adenoma               | X  X     X        X                    X  X  X              X     X      |         19 |
      Hepatocellular Adenoma, Multiple     |                X        X  X                    X              X        X|         14 |
      Histiocytic Sarcoma, Single          |    X        X                                                            |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                   X      |          1 |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +        +                                                        A   |   7        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +        +                                               +        +   |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +        +                                               +        +   |  11        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +        +                                                        +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +        +                                                        +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +        +                                                        +   |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5|            |
                                           | 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               |       X  X        X  X     X     X        X        X           X  X  X   |         19 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                      X                                                   |          1 |
      Follicular Cell, Adenoma, Multiple   |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +        +                 +        +           +                 +   |  15        |
      Cystadenoma, Papillary               |                                                                      X   |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +              +     +           +        +              +   |  19        |
      Leiomyosarcoma                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +        +                                                        +   |   8        |
      Femoral, Histiocytic Sarcoma, Single |    X                                                                     |          1 |
      Femoral, Lymphoma Malignant          |                                                                      X   |          1 |
      Femoral, Lymphoma Malignant Mixed    | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +              +              +        +                 +   |  19        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
      Mandibular, Histiocytic Sarcoma,     |                                                                          |            |
           Single                          |    X        X                                                            |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Mandibular, Lymphoma Malignant       |                                                                      X   |          1 |
      Mandibular, Lymphoma Malignant Mixed | X                                                                        |          4 |
      Mandibular, Sarcoma, Metastatic,     |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                      X   |          1 |
      Mediastinal, Lymphoma Malignant Mixed| X                                                                        |          3 |
      Pancreatic, Leiomyosarcoma,          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5|            |
                                           | 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Metastatic, Intestine Large      |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      | X                          X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                    +                       +                 +   |  12        |
      Histiocytic Sarcoma, Single          |    X                                                                     |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Lymphoma Malignant Mixed             | X                          X                                             |          7 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +        +     +              +  +     +              +  +  +|  28        |
      Hemangiosarcoma                      |                                                                         X|          3 |
      Histiocytic Sarcoma, Single          |             X                                                            |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                       X      |          2 |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Lymphoma Malignant Mixed             | X                          X                                             |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M        M                                                        +   |   6        |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +  +                                                            |   8        |
      Adenocarcinoma                       |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +                                                        +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +        +                                +                       +   |   9        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +        +                                                        +   |   8        |
      Histiocytic Sarcoma, Single          |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                              X                 X  X      |          7 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                      X                                                   |          1 |
      Histiocytic Sarcoma, Single          |    X        X                                                            |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +        +                                                        +   |   8        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5|            |
                                           | 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +        +                                                        +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                               +         |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                 +                             +         |   4        |
      Adenocarcinoma                       |                X                                               X         |          2 |
      Adenoma                              |                                  X                                       |          1 |
      Bilateral, Adenoma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +        +              +                             +           +   |  11        |
      Histiocytic Sarcoma, Single          |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             | X                          X                             X               |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +                                                        +   |   9        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                      X   |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                       X      |          2 |
      Lymphoma Malignant Mixed             | X                          X                             X               |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|             
                                           | 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +                                M     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +                                +     +     +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +                                +     +     +  +           +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                          X               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                                                       X                  |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |          X                 X        X        X                 X        X|             
      Hepatocellular Carcinoma, Multiple   | X                 X  X  X        X                                X      |             
      Hepatocellular Adenoma               |          X              X           X        X  X  X           X         |             
      Hepatocellular Adenoma, Multiple     | X  X  X        X  X        X  X        X                 X  X        X  X|             
      Histiocytic Sarcoma, Single          |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                           X                          X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                   X                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +                          +     +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +                                +     +     +              +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +                             +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +                             +     +     +              +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +                                +     +     +              +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|             
                                           | 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Adenoma                     |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +                                +     +     +              +  +|             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X     X  X              X              X        X        X         |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Pars Intermedia, Adenoma             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                              X                           |             
      Follicular Cell, Adenoma, Multiple   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +              +     +     +     M  +  +              +  +|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |    X                                                                     |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +                 +  +        +     +              +  +|             
      Hemangiosarcoma                      |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +                                +     +     +              +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Femoral, Lymphoma Malignant          |                                                                          |             
      Femoral, Lymphoma Malignant Mixed    |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Undifferentiated Cell Type       |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +        +           +     +  +  +     +           M  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |    X                                                                     |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                      X   |             
      Mandibular, Hemangiosarcoma,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|             
                                           | 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Liver                |                                                       X                  |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |    X  X     X           X                                                |             
      Mandibular, Lymphoma Malignant Mixed |                X                          X                          X  X|             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |          X                                                               |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |    X  X     X                                                            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                      X   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                              X                           |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                              X                           |             
      Renal, Lymphoma Malignant Lymphocytic|    X                                                                     |             
      Renal, Lymphoma Malignant Mixed      |                                                                      X   |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +                       +     +  +                    M  +  +|             
      Lymphoma Malignant Lymphocytic       |    X  X     X                                                            |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +                       +  +  +     +  +  +     +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X        X                                                            |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                         X              X  X        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                   X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M                                +     +     +              +  +|             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  +  +                                +  +  +     +              +  +|             
      Adenocarcinoma                       |                                              X                           |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +                                +     +     +              +  +|             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |    X  X                                                                  |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|             
                                           | 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Histiocytic Sarcoma, Single          |                                                       X                  |             
      Lymphoma Malignant Lymphocytic       |    X        X                                                            |             
      Lymphoma Malignant Mixed             |                                           X                          X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +                                +     +     +              +  +|             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    M  +  +                                +     +     +              +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X  X     X           X                                                |             
      Lymphoma Malignant Mixed             | X              X                    X     X              X  X        X  X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |          X                                   X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +     A              +     +           A  M     +                 A   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +              +     +           +  A     +                 A   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +              +     +           +  A     +                 +   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +        +     +     +        +  +  +     +                 +   |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +              +     +           +        +                 A   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +              +     +           M        +                 A   |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +        +     +     +        +  +  +     +                 +   |  19        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                      X   |          2 |
      Peyer's Patch, Lymphoma Malignant    |                                              X                           |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                   X                    X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                         X        X                                       |          2 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatoblastoma                       |                                                 X                        |          1 |
      Hepatocellular Carcinoma             | X  X  X  X                                            X                  |         11 |
      Hepatocellular Carcinoma, Multiple   |             X  X  X  X  X  X  X  X     X  X     X        X  X           X|         20 |
      Hepatocellular Adenoma               | X     X                 X  X  X  X        X  X  X  X                     |         17 |
      Hepatocellular Adenoma, Multiple     |                                     X                 X     X  X     X   |         17 |
      Histiocytic Sarcoma, Single          |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          2 |
      Lymphoma Malignant Mixed             |                               X                    X                    X|          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +              +     +           +  +     +                 A   |  16        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +              +     +           +  +     +                 M   |  15        |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +              +     +           +  A     +           +     +   |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +              +     +           +  A     +           +     +   |  17        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Squamous Cell Papilloma              |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +     +              +     +           +  A     +                 +   |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +              +     +           +  +     +                 +   |  16        |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +              +     +           +  +     +                 +   |  16        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +              +     +           +  +     +                 +   |  16        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                              X                           |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +              +     +           +  +     +                 A   |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +              +     +           +  +     +                 +   |  15        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               |    X           X  X                             X     X  X     X         |         14 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                    X                     |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                            X                                   X         |          3 |
      Follicular Cell, Adenoma, Multiple   |                                                          X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +     +              +     +  +        +  +  +  +           +  +  +  +|  24        |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +              +     +           +  +     +              +  +   |  20        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +              +     +           +  +     +                 +   |  16        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          2 |
      Femoral, Lymphoma Malignant          |                                              X                           |          1 |
      Femoral, Lymphoma Malignant Mixed    |                                                    X                     |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     A        +     +     +           +  +  +  +  +     +        +  +|  25        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mandibular, Hemangiosarcoma,         |                                                                          |            |
          Metastatic, Liver                |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          5 |
      Mandibular, Lymphoma Malignant Mixed |                               X                    X  X                  |          7 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          4 |
      Mediastinal, Lymphoma Malignant      |                                              X                           |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                    X                    X|          3 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                   X           X                                          |          3 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          A        +           +              +  +           +        +   |  14        |
      Lymphoma Malignant Lymphocytic       |                                                                      X   |          4 |
      Lymphoma Malignant                   |                                              X                           |          1 |
      Lymphoma Malignant Mixed             |                   X           X                             X            |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +     +  +  +        +  +  +  +  +  +              +  +|  31        |
      Hemangiosarcoma                      |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          3 |
      Lymphoma Malignant                   |                                              X                           |          1 |
      Lymphoma Malignant Mixed             |       X     X     X           X        X           X  X                 X|         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     M              +     +           +  M     +                 M   |  12        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                               X                    X                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +              +     +           +  +     +                 +   |  16        |
      Adenocarcinoma                       |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +              +     +           +  +     +                 +   |  16        |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          2 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +              +     +           +  +     +                 +   |  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +              +     +           +  +     +                 +   |  16        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Histiocytic Sarcoma, Single          |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          3 |
      Lymphoma Malignant Mixed             |                               X                    X                    X|          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +              +     +           +  +     +                 +   |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                 +                        |   1        |
      Adenoma                              |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +              +     +           +  +     +                 +   |  16        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                              X                           |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +              +     +           +  A     +                 A   |  13        |
      Lymphoma Malignant Lymphocytic       |    X                                                                     |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                              X                           |          1 |
      Lymphoma Malignant Lymphocytic       |    X                                                                 X   |          6 |
      Lymphoma Malignant Mixed             |       X     X     X           X        X           X  X     X           X|         17 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|             
                                           | 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +        +  +        +  A                       M  +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +        +  +  +                    +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +        +  +  +                    +  +            |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                               X                                          |             
      Hepatoblastoma                       |                                                          X               |             
      Hepatocellular Carcinoma             |                         X     X           X                       X      |             
      Hepatocellular Carcinoma, Multiple   | X  X           X                             X  X  X  X  X           X  X|             
      Hepatocellular Adenoma               |       X                       X              X  X     X           X      |             
      Hepatocellular Adenoma, Multiple     |             X        X     X        X  X  X        X           X         |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X  X                       X              X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                    X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Fibrosarcoma, Metastatic, Skin       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +        +  +                       +  +  +         |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +        +  +                       +  +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +        +  +                       +  +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +        +  +                       +  +            |             
      Corticomedullary Junction, Lymphoma  |                                                                          |             
          Malignant Mixed                  |                      X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +           +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +           +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +        +  +        +  +                       +  +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|             
                                           | 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Pars Distalis, Adenoma               |    X        X     X  X  X     X     X  X        X  X  X        X     X  X|             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Adenoma, Multiple   |                      X              X           X                        |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +        +  +        +  +  +         |             
      Cystadenoma, Papillary               |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                      X                                      X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +        +  +        +  +     +  +     +        +  +  +         |             
      Histiocytic Sarcoma, Single          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  +        +  +     +                 +  +        +   |             
      Axillary, Lymphoma Malignant Mixed   |                      X                                                   |             
      Lumbar, Lymphoma Malignant Mixed     |                   X  X                                                   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mandibular, Histiocytic Sarcoma,     |                                                                          |             
           Single                          |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                   X  X                                      X            |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       | X                                                                        |             
      Mediastinal, Lymphoma Malignant Mixed|                   X  X                                      X            |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       | X                                                                        |             
      Pancreatic, Lymphoma Malignant Mixed |                      X                                      X            |             
      Renal, Lymphoma Malignant Mixed      |                   X  X                                      X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +        +  +                                               +   |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X  X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                    X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|             
                                           | 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Hemangiosarcoma                      |                               X                                          |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                   X|             
      Lymphoma Malignant Mixed             |                   X  X  X                    X              X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +        M  +        M  +                       M  M            |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +        +  +        +  +                       M  M            |             
      Adenocarcinoma                       |          X                       X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +        +  +                       +  +            |             
      Subcutaneous Tissue, Fibrosarcoma    |    X                                                                     |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                      X                                                   |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +        +  +                       +  +            |             
      Lumbar, Osteosarcoma                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +        +  +                       +  +            |             
      Histiocytic Sarcoma, Single          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                 X        X                           |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                         X                                                |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |    X                                                                     |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                   X  X  X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +        +  +                          +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|             
                                           | 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +        +  +                       +  +            |             
      Lymphoma Malignant Mixed             |                   X  X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +        +  +                       +  +            |             
      Lymphoma Malignant Mixed             |                   X  X                                                   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                   X|             
      Lymphoma Malignant Mixed             |                   X  X  X                    X              X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                    X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5|            |
                                           | 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                 +                             +                    +   |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A                 A                             A                    A   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                 +                             A                    A   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                 +                             A                    A   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                 A                             A                    +   |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                 A                             A                    +   |  13        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |             X        X              X  X                    X            |          9 |
      Hepatocellular Carcinoma, Multiple   |                         X  X     X                    X                  |         14 |
      Hepatocellular Adenoma               |       X  X        X                             X  X        X        X  X|         14 |
      Hepatocellular Adenoma, Multiple     | X  X           X     X     X  X  X     X  X  X           X     X  X      |         21 |
      Histiocytic Sarcoma, Single          |                                           X     X                        |          2 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                   X                                                      |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                 A                             A                    +   |  13        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                 +                             +                    +   |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                 +              +              +                    A   |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                 +              +              +                    A   |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                 +                             +                    A   |  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                 +                             +                    +   |  14        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | I                 +                             +                    A   |  12        |
      Corticomedullary Junction, Lymphoma  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5|            |
                                           | 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | I                 +                             +                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | I                 +                             +                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                 A                             A                    +   |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                 +                             +                    M   |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Adenoma               |                X     X  X  X        X  X     X        X  X     X  X     X|         26 |
      Pars Intermedia, Adenoma             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |       X                                                                  |          1 |
      Follicular Cell, Adenoma, Multiple   |                X                    X  X              X           X     X|          9 |
      Follicular Cell, Carcinoma           |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +              M                             +        +  +     +  +  +|  25        |
      Cystadenoma, Papillary               |    X                                                     X               |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                   +     +     +           +  +  +                    A   |  20        |
      Histiocytic Sarcoma, Single          |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                 +                             A                    +   |  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M              +  +     +                 +     +  +              +  A   |  19        |
      Axillary, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                   X      |          1 |
      Mandibular, Histiocytic Sarcoma,     |                                                                          |            |
           Single                          |                                                 X                        |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          3 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                   X      |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                   X                                                      |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5|            |
                                           | 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          2 |
      Renal, Lymphoma Malignant Mixed      |                   X                                                      |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +                          +        +              +      |   9        |
      Histiocytic Sarcoma, Single          |                                           X                              |          1 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +           +  +  +        +     +  +  +     +     +  +        +  +  M|  34        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma, Single          |                                           X     X                        |          2 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          3 |
      Lymphoma Malignant Mixed             |                   X                                                      |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                 M                             M                    M   |   5        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                 +                             M                    +   |  11        |
      Adenocarcinoma                       | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +                             +                 +  +   |  15        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                   X                                                      |          2 |
      Subcutaneous Tissue, Sarcoma         |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                 +                             +                    +   |  14        |
      Lumbar, Osteosarcoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                 +                             +                    +   |  14        |
      Histiocytic Sarcoma, Single          |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5|            |
                                           | 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma         |             X                       X                                    |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                            X                       X                     |          2 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Histiocytic Sarcoma, Single          |                                           X     X                        |          2 |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | M                 +                             +                    +   |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | M                 +                             +                    A   |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                 +                             +                 +  +   |  15        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                 A                             A                    A   |  11        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                X                                                         |          3 |
      Lymphoma Malignant Mixed             |                   X                                X                     |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                   X      |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  M  +  +  +  +  +  M  +  +  A  M  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                 X           X            |             
      Hepatoblastoma                       |                         X                                                |             
      Hepatocellular Carcinoma             |                                  X                                       |             
      Hepatocellular Carcinoma, Multiple   | X  X  X     X  X  X     X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Hepatocellular Adenoma               |    X                    X     X                       X                 X|             
      Hepatocellular Adenoma, Multiple     |          X                                      X                        |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |          X              X                                               X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                         +      |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant Mixed             |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  M  +  +  +  +  +  M  +  +  M  +  M  M  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X  X     X  X     X     X  X        X        X                 X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Follicular Cell, Adenoma             |             X                                                            |             
      Follicular Cell, Adenoma, Multiple   | X     X  X     X        X  X     X        X  X  X     X  X  X     X  X  X|             
      Follicular Cell, Carcinoma           |                   X     X                          X        X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                              X                           |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                    X                     |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                         X                                               X|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Undifferentiated Cell  |                                                                          |             
          Type                             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Histiocytic Sarcoma, Single          |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Femoral, Histiocytic Sarcoma, Single |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                    X                     |             
      Femoral, Lymphoma Malignant Mixed    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Undifferentiated Cell Type       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                                     X                                    |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                     X                                    |             
      Mandibular, Histiocytic Sarcoma,     |                                                                          |             
           Single                          |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |    X                                               X  X                  |             
      Mandibular, Lymphoma Malignant Mixed |          X              X                                               X|             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                         X                                               X|             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                     X                                    |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                         X|             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                 +           +      |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemangiosarcoma                      |                               X                                          |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                               X  X                  |             
      Lymphoma Malignant Mixed             |          X              X                                               X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  M  M  +  M  M  +  M  M  M  M  +  M  +  M  M  M  M  M  +  M|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  M  +  M  +  M  M  +  +  M  +  +  +  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                         X                                                |             
      Subcutaneous Tissue, Mast Cell Tumor |                                                                          |             
          Benign                           |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                X              X                             X  X  X  X   |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                               X  X                  |             
      Lymphoma Malignant Mixed             |          X                                                              X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                           +         |             
      Adenoma                              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X  X                  |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                               X  X                  |             
      Lymphoma Malignant Mixed             |          X              X                                               X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  M  +  A  +  M  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Undifferentiated Cell Type       |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Hepatoblastoma                       |                                                 X                        |          2 |
      Hepatocellular Carcinoma             |    X                 X                                                   |          3 |
      Hepatocellular Carcinoma, Multiple   | X     X  X  X  X  X     X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X|         44 |
      Hepatocellular Adenoma               |                               X  X  X                 X     X           X|         11 |
      Hepatocellular Adenoma, Multiple     |             X                                                            |          3 |
      Histiocytic Sarcoma, Single          |                                                                   X      |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             | X                                                                        |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma, Single          |                                                                   X      |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                X     X   |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  +  +  M  M  M  +  +  +  M  +  +  M  +  +  M  M  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               | X  X     X     X     X     X     X  X           X     X  X     X  X  X   |         26 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
      Follicular Cell, Adenoma             |       X     X                                X                           |          4 |
      Follicular Cell, Adenoma, Multiple   | X  X     X     X     X     X  X     X           X     X  X  X  X  X  X   |         31 |
      Follicular Cell, Carcinoma           |    X     X                 X     X                                       |          8 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                      +   |   1        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cystadenoma                          |                X                                                         |          2 |
      Granulosa Cell Tumor Benign          |                               X                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                       X                  |          2 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  | X                                                                        |          3 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Undifferentiated Cell  |                                                                          |            |
          Type                             |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Histiocytic Sarcoma, Single          |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Histiocytic Sarcoma, Single |                                                                   X      |          1 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Femoral, Lymphoma Malignant Mixed    | X                                                                        |          2 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Undifferentiated Cell Type       |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Inguinal, Lymphoma Malignant Mixed   | X                                                                        |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                     X                                    |          1 |
      Lumbar, Lymphoma Malignant Mixed     | X                                                                        |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mandibular, Histiocytic Sarcoma,     |                                                                          |            |
           Single                          |                                                                   X      |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                     X                 X     X            |          6 |
      Mandibular, Lymphoma Malignant Mixed | X                                                                        |          4 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                      X   |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                     X                                    |          1 |
      Mediastinal, Lymphoma Malignant Mixed| X                                                                        |          3 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                X         |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   4        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma, Single          |                                                                   X      |          1 |
      Lymphoma Malignant Lymphocytic       |                                     X                 X     X            |          6 |
      Lymphoma Malignant Mixed             | X        X                                                               |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                X     X   |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  M  M  +  +  +  +  +  M  +  M  +  M  M  M  +  M  +  M  M  +|  23        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  M  +  M  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |             X                                                            |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
      Subcutaneous Tissue, Mast Cell Tumor |                                                                          |            |
          Benign                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                  X                                       |          1 |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |          X                                                               |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |       X                                                                  |          7 |
      Histiocytic Sarcoma, Single          |                                                                   X      |          1 |
      Lymphoma Malignant Lymphocytic       |                                     X                 X     X            |          6 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Cell Type                        |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +  +                                                   |   4        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             | X                                                                        |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                       X                  |          2 |
      Lymphoma Malignant Mixed             | X                                                                        |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                     X                 X     X            |          6 |
      Lymphoma Malignant Mixed             | X        X                                                               |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                X     X   |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  M  +  +  +  M  M  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                        X                                 |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatoblastoma                       |             X                       X        X              X  X  X      |             
      Hepatoblastoma, Multiple             |                                                                          |             
      Hepatocellular Carcinoma             |                                           X     X                        |             
      Hepatocellular Carcinoma, Multiple   | X  X  X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X   |             
      Hepatocellular Adenoma               |                            X     X              X     X                  |             
      Hepatocellular Adenoma, Multiple     |                               X           X                              |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |       X     X                                               X        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |       X                                                     X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  M  M  M  +  M  M  +  +  +  +  +  M  +  +  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X           X  X                 X  X           X  X  X  X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Follicular Cell, Adenoma             |       X  X        X        X           X     X                       X   |             
      Follicular Cell, Adenoma, Multiple   |    X        X  X              X     X           X  X  X  X  X  X  X      |             
      Follicular Cell, Carcinoma           |                X                                      X  X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma, Papillary               |                                                                          |             
      Yolk Sac Carcinoma                   |                                                                         X|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                            X           X                                 |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Polyp Stromal                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Lymphoma Malignant Mixed    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                      X   |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                      X   |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mandibular, Histiocytic Sarcoma,     |                                                                          |             
           Single                          |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                            X           X     X                           |             
      Mandibular, Lymphoma Malignant Mixed |       X     X                                               X        X   |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Mediastinal, Histiocytic Sarcoma,    |                                                                          |             
           Single                          |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                            X           X     X                           |             
      Mediastinal, Lymphoma Malignant Mixed|       X                                                     X        X   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
      Renal, Histiocytic Sarcoma, Single   |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                      X   |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +                 +                    +        +   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                             X        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                             X            |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X                 X                           |             
      Lymphoma Malignant Mixed             |       X     X                                               X        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  M  I  M  +  +  +  M  +  +  M  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                            X                                             |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X        X                                 |             
      Alveolar/Bronchiolar Carcinoma       |                                              X                           |             
      Hepatoblastoma, Metastatic, Liver    |                                                                          |             
      Hepatocellular Carcinoma, Multiple,  |                                                                          |             
           Metastatic, Liver               |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                          X  X        X                                 |             
      Histiocytic Sarcoma, Single          |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X           X                                 |             
      Lymphoma Malignant Mixed             |       X     X                                               X        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                          +                                          |             
      Adenocarcinoma                       |                               X                                          |             
      Adenoma                              |    X                                                                     |             
      Histiocytic Sarcoma, Single          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                            X                 X                           |             
      Lymphoma Malignant Mixed             |       X     X                                               X        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
      Renal Tubule, Adenocarcinoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Lymphocytic       |                            X                                             |             
      Lymphoma Malignant Mixed             |       X                                                     X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                            X           X     X                           |             
      Lymphoma Malignant Mixed             |       X     X                                               X        X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +|  39        |
      Lymphoma Malignant Mixed             |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  48        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatoblastoma                       |                                                 X  X                     |          8 |
      Hepatoblastoma, Multiple             |       X                                                                  |          1 |
      Hepatocellular Carcinoma             |                                                    X                     |          3 |
      Hepatocellular Carcinoma, Multiple   |    X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X|         45 |
      Hepatocellular Adenoma               |                                  X     X     X           X        X  X   |         10 |
      Hepatocellular Adenoma, Multiple     | X                 X  X  X                                               X|          7 |
      Histiocytic Sarcoma, Single          | X                                                           X            |          2 |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          2 |
      Lymphoma Malignant Mixed             |                      X              X                                    |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                      X                    X                              |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma, Single          | X                                                                        |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  67                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M  +  M  M  +  M  M  +  M  M  M  +  +  +  M  +  +  +  M  +  +  +|  24        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Pars Distalis, Adenoma               |       X        X  X     X        X  X  X  X  X     X     X     X  X  X   |         24 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                      X                                                   |          1 |
      Follicular Cell, Adenoma             |       X  X  X                                         X        X         |         12 |
      Follicular Cell, Adenoma, Multiple   | X              X  X     X        X  X  X  X  X  X  X     X        X  X   |         26 |
      Follicular Cell, Carcinoma           |                                        X                                 |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Cystadenoma, Papillary               |                                                                         X|          1 |
      Yolk Sac Carcinoma                   |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                         X                                                |          3 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                              X                           |          2 |
      Lymphoma Malignant Mixed             |                      X                                                   |          1 |
      Polyp Stromal                        |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Lymphoma Malignant Mixed    |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mandibular, Histiocytic Sarcoma,     |                                                                          |            |
           Single                          | X                                                           X            |          2 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                         X                    X                           |          5 |
      Mandibular, Lymphoma Malignant Mixed |                                     X     X                       X      |          7 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Histiocytic Sarcoma,    |                                                                          |            |
           Single                          | X                                                           X            |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          3 |
      Mediastinal, Lymphoma Malignant Mixed|                                     X     X                              |          5 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Histiocytic Sarcoma, Single   | X                                                                        |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                    +           +                          +     +      |   9        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                  X                                       |          1 |
      Histiocytic Sarcoma, Single          | X                                                           X            |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                      X                                            X      |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma, Single          | X                                                           X            |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                         X                    X                           |          4 |
      Lymphoma Malignant Mixed             |                      X              X     X                              |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +  M  +  M  +  +|  33        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|  37        |
      Adenocarcinoma                       |                                  X                                       |          1 |
      Fibroadenoma                         |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosarcoma    |                                        X                                 |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                         X                 X                              |          4 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatoblastoma, Metastatic, Liver    |    X  X     X                                X                           |          4 |
      Hepatocellular Carcinoma, Multiple,  |                                                                          |            |
           Metastatic, Liver               |       X                                                                  |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X                                                                     |          5 |
      Histiocytic Sarcoma, Single          | X                                                           X            |          2 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                    X                           |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                     X     X                              |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   3        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                                                          |          1 |
      Histiocytic Sarcoma, Single          | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             |                      X              X     X                              |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Renal Tubule, Adenocarcinoma         |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                         X                                                |          2 |
      Lymphoma Malignant Mixed             |                      X                                                   |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Lymphocytic       |                         X                    X                           |          5 |
      Lymphoma Malignant Mixed             |                      X              X     X                       X      |          8 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  A  +  +  M  A  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                                        X                                 |             
      Hepatocellular Carcinoma             |       X                       X     X  X                 X               |             
      Hepatocellular Carcinoma, Multiple   |                                           X                    X         |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                 +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +  +|             
      Pulp, Lymphoma Malignant             |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Subcapsular, Adenoma   |                                                                          |             
      Spindle Cell, Subcapsular, Adenoma,  |                                                                          |             
           Multiple                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Pars Intermedia, Adenoma             |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                          +               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +              +                                                     +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Femoral, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +           +     +              +   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                         X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X                                                  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +     +  M  +  M  M  M  +  +  M  +  M  M  +  +  M  M  M  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                 X                        |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                         X                                                |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                       X     X  X  X              X     X         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urethra                                 | +                                +                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                   X                                                  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  40        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Adenocarcinoma                       |                                                                         X|          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                X                                                        X|          2 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             |    X                                         X  X           X            |          9 |
      Hepatocellular Carcinoma, Multiple   |          X                    X                                          |          4 |
      Hepatocellular Adenoma               |                      X        X     X  X  X     X     X     X            |          8 |
      Hepatocellular Adenoma, Multiple     |                            X                 X                           |          3 |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                             +                 +     +               |   6        |
      Lymphoma Malignant Lymphocytic       |                                  X                       X               |          2 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  77                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +                              |   1        |
      Squamous Cell Papilloma              |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                  +              +              +         |   5        |
      Pulp, Lymphoma Malignant             |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spindle Cell, Subcapsular, Adenoma   |                                        X                                 |          1 |
      Spindle Cell, Subcapsular, Adenoma,  |                                                                          |            |
           Multiple                        |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  M  +  M  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Carcinoma           |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  78                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                       +                  |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   4        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                      +                                                   |   1        |
      Lymphoma Malignant Lymphocytic       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Femoral, Lymphoma Malignant Mixed    |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                                        X                                 |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                        X                                 |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                  X                                       |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                        X                                 |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +        +     +  +     +  +  +     +           +                    +|  14        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  79                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                      X           X                                       |          3 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  M  +  +  +  +  M  +  +  +  M  I  I  +  M  +  +  +  +  +  M|  29        |
      Lymphoma Malignant Lymphocytic       |                                                          X               |          1 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibroma         |                         X                                                |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                    X                     |          1 |
      Subcutaneous Tissue, Sarcoma         |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                         X           X                                   X|          4 |
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X                          X                 X                        |         10 |
      Lymphoma Malignant Lymphocytic       |                      X           X                                       |          2 |
      Lymphoma Malignant Mixed             |                                                    X                     |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  80                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +        +                       +                 +            |   4        |
      Adenoma                              |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                      X           X                       X               |          4 |
      Lymphoma Malignant Mixed             |                                                    X                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  81                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|             
                                           | 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +        +        +     +  M              A  A  A  A  A     A  +      |             
      Fibrosarcoma, Metastatic, Skin       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +        +     +  +              +  +  +  +  +     A  +      |             
      Adenocarcinoma                       | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |    X                                                                     |             
      Hemangiosarcoma                      |                X                                                         |             
      Hepatocellular Carcinoma             |          X                             X                                 |             
      Hepatocellular Carcinoma, Multiple   |    X                    X                                                |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |       X              X                                      X            |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
      Fibrosarcoma, Metastatic, Skin       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +        +        +     +  +        +     +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +        +     +  +        +     +  +  +  +  +     +  +      |             
      Squamous Cell Papilloma              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +        +     +  +              +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +        +     +  +              +  +  +  +  +     +  +      |             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Uncertain Primary Site           | X  X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +        +     +  +              M  +  +  M  M     +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +  +  +  +     +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|             
                                           | 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                      +   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +        +        +     +  +              +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +        +     +  M        +     +  +  +  M  M     M  +     +|             
      Axillary, Sarcoma, Metastatic        |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +                          +                                +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +        +     +  +              +  +  +  +  +  +  +  +      |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M        +        +     M  M              +  +  +  +  +     M  M      |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +        +     +  +  +        +  +  +  +  +  +     +  +      |             
      Subcutaneous Tissue, Fibrosarcoma    |    X        X                 X                                   X      |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +        +     +  +              +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic,          |                                                                          |             
          Uncertain Primary Site           |    X                                                                     |             
      Alveolar/Bronchiolar Adenoma         |       X                                                        X        X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                        X                                 |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|             
                                           | 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +        +     +  +              +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                    +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Adenoma                              |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +        +     +  +           +  +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +        +     +  +              +  +  +  +  +     A  +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +              +  +  +  +  +  +                              |  22        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     A              +  +  +  A  A  +                              |  12        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     A              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     A              +  +  +  M  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     A              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     A              +  +  +  A  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     M     +        +  +  +  +  +  +                              |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     A              +  +  +  A  M  +                              |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +     A              +  +  +  M  +  +                              |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +     A     +        +  +  +  A  +  +                              |  20        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                    X  X     X        X   |          6 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          2 |
      Hepatocellular Adenoma               |                                                 X     X                  |          2 |
      Hepatocellular Adenoma, Multiple     |             X                                                            |          4 |
      Histiocytic Sarcoma                  |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     A              +  +  +  +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     M              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     A     +        +  +  +  +  +  +  +                           |  24        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     A     +        +  +  +  +  +  +  +                           |  24        |
      Squamous Cell Papilloma              |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     A              +  +  +  +  +  +                              |  21        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +              +  +  +  +  +  +                              |  23        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Uncertain Primary Site           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     M              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     M              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     M              +  +  +  +  +  +                              |  21        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  85                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     A              +  +  +  +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +     +              +  +  +  +  +  M                              |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +|  46        |
      Follicular Cell, Adenoma             |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +     +              +  +  +  +  +  +                              |  22        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                        +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +     +              +  +  +  +  +  +                              |  22        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                  +        +                              |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +     +              +  +  +  +  +  +                              |  22        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     A              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M     +        +  +  M  +  +  +  +              +     +      |  25        |
      Axillary, Sarcoma, Metastatic        |                            X                                             |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                   X      |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                   X      |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                   X      |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +        +                          +              +     +      |  11        |
      Lymphoma Malignant Mixed             |                   X                                               X      |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +     +        +  +  +  A  +  +     +                 +      |  25        |
      Lymphoma Malignant Mixed             |                   X                             X                 X      |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +     M              +  +  M  M  M  M                              |  11        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +     +        +  +  +  M  +  +                             +|  26        |
      Subcutaneous Tissue, Fibrosarcoma    |                   X                                                      |          5 |
      Subcutaneous Tissue, Sarcoma         |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  86                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     A              +  +  +  +  +  +                              |  21        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma, Metastatic,          |                                                                          |            |
          Uncertain Primary Site           |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                   X                          X                    X      |          6 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     A              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +              +  +  +  +  +  +                              |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +              +  +  +  +  +  +                              |  23        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                           +                              |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     A              +  +  +  +  +  +                              |  20        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma                  |                                                                         X|          1 |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                   X                             X                 X      |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  87                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|             
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|             
                                           | 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                    +              +                 +  +     +   |             
      Periesophageal Tissue, Sarcoma,      |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +     +              +              +              +  +  +     A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +              +              +              +  +  +     A   |             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                          X               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                   X                                                      |             
      Hepatoblastoma                       |                                                          X               |             
      Hepatocellular Carcinoma             |       X                                            X     X               |             
      Hepatocellular Carcinoma, Multiple   |                                                                X         |             
      Hepatocellular Adenoma               |       X                                X              X                  |             
      Hepatocellular Adenoma, Multiple     |                                  X                                       |             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                    +              +                 +  +     +   |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                    +              +                 +  +     A   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  M  +  +  +  +  +     +  +  +  +  I  I  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|             
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|             
                                           | 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                +         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +              +              +     +        +  +  +  +  +   |             
      Deep Cervical, Sarcoma, Metastatic,  |                                                                          |             
           Skin                            |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Renal, Lymphoma Malignant Lymphocytic|             X                                                            |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +                                   +        +     +  +      |             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             | X                                                        X               |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +              +              +                 +  +     +   |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M     +              M              +                 +  M     +   |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                +         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +                    +              +        +        +  +     +   |             
      Subcutaneous Tissue, Fibrosarcoma    |                            X                       X        X            |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |    X                                                                     |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +        +  +  +     +  +  +  +        +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|             
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|             
                                           | 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X     X                       X     X     X                     |             
      Alveolar/Bronchiolar Carcinoma       |                                                                X         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                X         |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |             X                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +                 +                                       |             
      Adenoma                              |          X     X                 X                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +                 +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             | X                                                        X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 1| 1| 2| 2| 1| 3| 3| 3| 7|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7|                                               |     L      |
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +           +                                                |   8        |
      Periesophageal Tissue, Sarcoma,      |                                                                          |            |
          Metastatic, Skin                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             A           +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +           +                                                |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +           +                                                |  10        |
      Adenocarcinoma                       | X                                                                        |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  33        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          3 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                      X                                                   |          4 |
      Hepatocellular Adenoma, Multiple     |    X                                                                     |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +           +                                                |   8        |
      Sarcoma, Metastatic, Skin            |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +           +                                                |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +           +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +           +                                                |   7        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  91                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 1| 1| 2| 2| 1| 3| 3| 3| 7|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7|                                               |     L      |
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             M           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |  28        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  33        |
      Follicular Cell, Adenoma             |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Prostate                                |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |             +           +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +           +                                                |  15        |
      Deep Cervical, Sarcoma, Metastatic,  |                                                                          |            |
           Skin                            |             X                                                            |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   7        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +           +                                                |  12        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M           M                                                |   4        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             M                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +        +                                                |  14        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  92                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 1| 1| 2| 2| 1| 3| 3| 3| 7|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |     A      |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7|                                               |     L      |
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |          4 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |             X                                                            |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +     +  +                                                |  25        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +           +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  33        |
      Alveolar/Bronchiolar Adenoma         | X  X  X  X     X                                                         |         10 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +           +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Adenoma                              |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +           +                                                |  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +           +                                                |   8        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +                                                |  33        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  93                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|             
                                           | 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  A        A              +  +  +        A  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +              +  +  +        +  +           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +              +  +  +        +  +           +  +  A         |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                            X                                             |             
      Hepatoblastoma                       |                                                                      X   |             
      Hepatocellular Carcinoma             |                                     X                                    |             
      Hepatocellular Carcinoma, Multiple   |                      X  X                                   X  X     X   |             
      Hepatocellular Adenoma               |          X                                X                       X     X|             
      Hepatocellular Adenoma, Multiple     |                X                                      X                  |             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +              +  +  +        +  A           +  +  A         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +              +  +  +        +  +           +  +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +              +  +  +        +  A           +  +  A         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +              +  +  +        +  +           +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M        +              +  +  M        M  M           +  +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|             
                                           | 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                                +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +        +              +  +  +        +  A           +  +  +         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +        +              +  +  +        +  +           +  +  +         |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +              +  +  +        +  A           +  +  +         |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Femoral, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +              +  +  +        M  +           +  +  +         |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                              X                           |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                              +                           |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +           +  +  +     +  +  A           +  +  A         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M        +              +  M  M        M  M           +  +  +         |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           M                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +           +  +  +  +     +  +  +           +  +  +         |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                            X           X                 X  X            |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|             
                                           | 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +     +  +  +  +  +        +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +              +  +  +        +  +           +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X              X     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +              +  +  +        +  +           +  +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +              +  +  +        +  A           +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Adenoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +              +  +  +     +  +  +           +  +  +         |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +              +  +  +        +  A           +  +  A         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                X         |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       A                 +                    M  +  +  A     +     +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                 +                    +  +  +  +     +     +     +|  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                 +                    +  +  +  +     +     +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                 +                    +  +  +  +     +     +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                 +                    +  +  +  +     +     +     +|  18        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |                                                 X                        |          1 |
      Hemangiosarcoma                      |          X                                   X                           |          2 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |       X  X  X                    X  X                 X     X  X  X     X|         11 |
      Hepatocellular Carcinoma, Multiple   |                X           X           X                                 |          8 |
      Hepatocellular Adenoma               |    X                          X           X     X  X  X              X  X|         12 |
      Hepatocellular Adenoma, Multiple     |                   X        X                                             |          4 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                             X            |          2 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                 +                    +  +  +  +     +     +      |  17        |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                 +                    +  +  +  +     +     +      |  19        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                 +                    +  +  +  +     +     +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                 +                    +  +  +  +     +     +      |  19        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +                 +                    +  +  +  +     +     +      |  17        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  97                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +                 +                    M  +  +  +     +     +      |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  I  +  M  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Adenoma             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +                 +                    +  +  +  +     +     +      |  18        |
      Lymphoma Malignant Lymphocytic       |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +              +  +                    +  +  +  +     +     +      |  20        |
      Interstitial Cell, Adenoma           |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                 +                    +  +  +  +     +     +      |  18        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                             X            |          1 |
      Femoral, Lymphoma Malignant Mixed    |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +     +     +  +                    +  +  +  +     +     +     +|  22        |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                             X            |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                             X            |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                      X                                      X            |          2 |
      Mandibular, Lymphoma Malignant Mixed |                                                 X                        |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                 X                        |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +     +                                +                        |   4        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  98                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +        +     +  +                    +  +  +  +     +     +      |  21        |
      Lymphoma Malignant Lymphocytic       |                      X                                      X            |          2 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                 +                    +  +  +  +     M     M      |  11        |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                 +                    +  +  +  +     +  +  +  +   |  23        |
      Squamous Cell Carcinoma              |                                                    X                     |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                   X  X   |          6 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                                             X            |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  42        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                 +                    +  +  +  +     +     +      |  19        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                X              X        X                                 |          6 |
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                X         |          2 |
      Lymphoma Malignant Lymphocytic       |                                                             X            |          1 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                 +                    +  +  +  +     +     +      |  19        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                 +                    +  +  +  +     +     +      |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                   +     +|   3        |
      Adenoma                              |                                                                   X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +        +        +                    +  +  +  +     +     +      |  21        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  99                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Liver                           |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |                                                             X            |          1 |
      Lymphoma Malignant Mixed             |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                 +                    +  +  +  +     +     +      |  17        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                      X                                      X            |          3 |
      Lymphoma Malignant Mixed             |                                                 X                        |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 100                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +  +  M  M  +  M  +     A     A        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +  +  +  +  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  +  M  M  +  M  +     +     A        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  +  A  +  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  +  M  +  +  M  +     +     M        +                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +  +  +  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +  +  M  M  +  M  +     +     A        +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +  +  A  M  +  M  +     +     +        +                     |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                      X   |             
      Hemangiosarcoma, Multiple            | X                                                                        |             
      Hepatocellular Carcinoma             |       X  X                                         X           X         |             
      Hepatocellular Carcinoma, Multiple   |    X                             X                       X           X   |             
      Hepatocellular Adenoma               |    X                                   X  X                 X            |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                           X                              |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  M  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  M  M  +  M  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +            |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |             +  +  M  M     M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +  +  I  +  I  +     A     +                              |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +  M  M  +  M  +     +     +        +        +        +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mandibular, Histiocytic Sarcoma      |                                                                          |             
      Mandibular, Lymphoma Malignant Mixed |                                     X                                    |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +        +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                      X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                             X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +  M  M  +  M  +  +  +     +     +  +     +  +        +   |             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                  X                       X  X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +  M  M  +  M  +     +     M        M                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                    M                     |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +  M  M  +  M  +  +  +     +  +  +  +     +  +        +   |             
      Schwannoma Malignant                 |                               X                                          |             
      Squamous Cell Papilloma              |                                                          X               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                           X  X                       X   |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                             X            |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                 X                        |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +  +  +  +  I  +  +  +  +  +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                        X     X  X              X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                    X                     |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                    X                     |             
      Histiocytic Sarcoma                  |                                           X                              |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +  M  +  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +  M  M  +  M  +     +     +        +                 +   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                    X                     |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                           X                              |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                  X  X                    X  X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1|            |
                                           | 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +  +  +     +                                      +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +     +                                      +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +     +                                      +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +     +                                      +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +     +                                      +  +        +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +     +                                      +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +     +                                      +  +        +  +|  16        |
      Lymphoma Malignant Mixed             |                                                             X            |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                      X                                                   |          2 |
      Hepatocellular Carcinoma             |                         X           X  X                                 |          7 |
      Hepatocellular Carcinoma, Multiple   |                               X           X     X           X            |          8 |
      Hepatocellular Adenoma               | X  X  X     X        X                 X  X                    X         |         12 |
      Hepatocellular Adenoma, Multiple     |                            X        X                 X                  |          3 |
      Histiocytic Sarcoma                  |                                                                      X   |          2 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                      +   |   1        |
      Histiocytic Sarcoma                  |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +     +                 +                    +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +     +                 +                    +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +     +                                      +           +  +|  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 105                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1|            |
                                           | 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M  +  +     +                                      M           +  +|  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +                                +                                 |   4        |
      Carcinoma                            |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +     +                                      +           +  +|  14        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +     +                                      +           +  I|  13        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +     +                             +        +  +        +  +|  20        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          1 |
      Mandibular, Histiocytic Sarcoma      |                                                                      X   |          1 |
      Mandibular, Lymphoma Malignant Mixed |                                                                          |          1 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |          X                                                               |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                             X            |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                 +                             +        M  +        +   |   8        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                      X   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 106                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1|            |
                                           | 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                             X            |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +     +                       +  +  +        +           +  +|  24        |
      Hemangiosarcoma                      | X                                                                        |          1 |
      Histiocytic Sarcoma                  |                                                                      X   |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                           X                              |          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  M  +     +                                      +           +  M|  11        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +     +                    +     +  +        +  +        +  +|  25        |
      Schwannoma Malignant                 |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                 X        X              X|          6 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                                                                          |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                              X                           |          2 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
          Sarcoma                          |                                                                      X   |          1 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     I  +  +  +  +  +     +  +  +  +     +  +  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Alveolar/Bronchiolar Adenoma         |    X                 X              X     X  X     X                     |         11 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 107                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1|            |
                                           | 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|     L      |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                     X                                    |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                      X   |          2 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                           X                              |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +     +                                      +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   1        |
      Adenoma                              |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +                                      +           +  +|  17        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +     +                                      +           +  +|  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma                  |                                                                      X   |          2 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                           X                 X            |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page 108                                                               
NTP Experiment-Test: 05076-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/15/97  
Route: DOSED FEED                                                                                                 Time: 14:20:40  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|             
                                           | 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +        +                          +  +     +                 +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A     +  M        M                          A  +     +                 A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +        +                 +        A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +  +        +                 +        A  +     A                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A     +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +  +        +                          A  +     A                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +                          A  +     +                 +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                             X            |             
      Hepatoblastoma                       |                         X                                                |             
      Hepatoblastoma, Multiple             |                               X                                          |             
      Hepatocellular Carcinoma             |                                        X  X           X  X  X            |             
      Hepatocellular Carcinoma, Multiple   |                         X  X  X  X                 X                     |             
      Hepatocellular Adenoma               |             X        X     X                                      X      |             
      Hepatocellular Adenoma, Multiple     |                   X                 X              X     X              X|             
      Histiocytic Sarcoma                  |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +        +                          +  +     +                 +|             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +        +                          +  +     +                 +|             
                                            __________________________________________________________________________|             
   Stomach                                 | A     +  +        +                          +  +     +  +     +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A     +  +        +                          +  +     +  +     +        +|             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A     +  +        +                          +  +     +                 +|             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +        +                          +  +     +                 +|